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https://www.readbyqxmd.com/read/29032294/one-year-double-blind-study-of-high-vs-low-frequency-subcallosal-cingulate-stimulation-for-depression
#1
Renana Eitan, Denys Fontaine, Michel Benoît, Caroline Giordana, Nelly Darmon, Zvi Israel, Eduard Linesky, David Arkadir, Shiri Ben-Naim, Moshe Iserlles, Hagai Bergman, Natasha Hulse, Mohamed Abdelghani, Peter McGuffin, Anne Farmer, Peichel DeLea, Keyoumars Ashkan, Bernard Lerer
Subcallosal Brodmann's Area 25 (Cg25) Deep Brain Stimulation (DBS) is a new promising therapy for treatment resistant major depressive disorder (TR-MDD). While different DBS stimulating parameters may have an impact on the efficacy and safety of the therapy, there is no data to support a protocol for optimal stimulation parameters for depression. Here we present a prospective multi-center double-blind randomized crossed-over 13-month study that evaluated the effects of High (130 Hz) vs Low (20 Hz) frequency Cg25 stimulation for nine patients with TR-MDD...
October 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28983489/study-of-memory-deficit-in-alzheimer-s-disease-by-means-of-complexity-analysis-of-fnirs-signal
#2
David Perpetuini, Roberta Bucco, Michele Zito, Arcangelo Merla
Working memory deficit is a signature of Alzheimer's disease (AD). The free and cued selective reminding test (FCSRT) is a clinical test that quantifies memory deficit for AD diagnosis. However, the diagnostic accuracy of FCSRT may be increased by accompanying it with neuroimaging. Since the test requires doctor-patient interaction, brain monitoring is challenging. Functional near-infrared spectroscopy (fNIRS) could be suited for such a purpose because of the fNIRS flexibility. We investigated whether the complexity, based on sample entropy and multiscale entropy metrics, of the fNIRS signal during FCSRT was correlated with memory deficit in early AD...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/28975777/the-evolving-role-of-drug-coated-balloons-for-the-treatment-of-complex-femoropopliteal-lesions
#3
Grigorios Korosoglou, Michael Lichtenberg, Sultan Celik, Joachim Andrassy, Marianne Brodmann, Martin Andrassy
INTRODUCTION: Conventional therapies for transcatheter treatment of patients with infrainguinal obstructive disease remain compromised by high restenosis rates. Drug-coated balloons (DCB) offer a novel therapeutic alternative targeting the source of neo-intimal hyperplasia, without the need for a permanent endovascular scaffold and their inherent limitations. EVIDENCE ACQUISITION: A systematic research of the medical databases (Pubmed) has been conducted for this up-to-date review...
October 2, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28955311/safety-of-novel-microbes-for-human-consumption-practical-examples-of-assessment-in-the-european-union
#4
REVIEW
Theodor Brodmann, Akihito Endo, Miguel Gueimonde, Gabriel Vinderola, Wolfgang Kneifel, Willem M de Vos, Seppo Salminen, Carlos Gómez-Gallego
Novel microbes are either newly isolated genera and species from natural sources or bacterial strains derived from existing bacteria. Novel microbes are gaining increasing attention for the general aims to preserve and modify foods and to modulate gut microbiota. The use of novel microbes to improve health outcomes is of particular interest because growing evidence points to the importance of gut microbiota in human health. As well, some recently isolated microorganisms have promise for use as probiotics, although in-depth assessment of their safety is necessary...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28954877/disparate-effects-of-training-on-brain-activation-in-parkinson-disease
#5
Inbal Maidan, Keren Rosenberg-Katz, Yael Jacob, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
OBJECTIVE: To compare the effects of 2 forms of exercise, i.e., a 6-week trial of treadmill training with virtual reality (TT + VR) that targets motor and cognitive aspects of safe ambulation and a 6-week trial of treadmill training alone (TT), on brain activation in patients with Parkinson disease (PD). METHODS: As part of a randomized controlled trial, patients were randomly assigned to 6 weeks of TT (n = 17, mean age 71.5 ± 1.5 years, disease duration 11.6 ± 1...
September 27, 2017: Neurology
https://www.readbyqxmd.com/read/28946572/anodal-transcranial-direct-current-stimulation-over-the-right-hemisphere-improves-auditory-comprehension-in-a-case-of-dementia
#6
Vanessa Costa
BACKGROUND: Noninvasive transcranial stimulation methods have been increasingly employed in order to improve cognitive performance in neurological patients. In previous studies with both stroke patients and healthy subjects, noninvasive stimulation of temporal-parietal regions and their homologue produced an improvement in linguistic tasks. OBJECTIVE: The aim of the current study was to evaluate if anodal transcranial direct current stimulation (tDCS) over Brodmann areas 39/40 (angular and supramarginal gyri) could promote the recovery of linguistic functions, in particular comprehension and naming, in a single patient affected by dementia...
September 16, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28942466/assessing-the-clinical-outcome-of-vim-radiosurgery-with-voxel-based-morphometry-visual-areas-are-linked-with-tremor-arrest
#7
Constantin Tuleasca, Tatiana Witjas, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Dimitri Van de Ville, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the Vim RS outcome using voxel-based morphometry by evaluating the interaction between clinical response and time. METHODS: Thirty-eight patients with right-sided ET benefited from left unilateral Vim RS...
September 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28931302/learning-metabolic-brain-networks-in-mci-and-ad-by-robustness-and-leave-one-out-analysis-an-fdg-pet-study
#8
Zhijun Yao, Bin Hu, Xuejiao Chen, Yuanwei Xie, Jürg Gutknecht, Dennis Majoe
This study attempted to better understand the properties associated with the metabolic brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Graph theory was employed to investigate the topological organization of metabolic brain network among 86 patients with MCI, 89 patients with AD, and 97 normal controls (NCs) using 18F fluoro-deoxy-glucose positron emission tomography (FDG-PET) data. The whole brain was divided into 82 areas by Brodmann atlas to construct networks. We found that MCI and AD showed a loss of small-world properties and topological aberrations, and MCI showed an intermediate measurement between NC and AD...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28926418/hemispheric-dominance-for-stereognosis-in-a-patient-with-an-infarct-of-the-left-postcentral-sensory-hand-area
#9
Jorge Moll, Ricardo de Oliveira-Souza
The concept of left hemispheric dominance for praxis, speech, and language has been one of the pillars of neurology since the mid-19th century. In 1906, Hermann Oppenheim reported a patient with bilateral stereoagnosia (astereognosis) caused by a left parietal lobe tumor and proposed that the left hemisphere was also dominant for stereognosis. Surprisingly, few cases of bilateral stereoagnosia caused by a unilateral cerebral lesion have been documented in the literature since then. Here we report a 75-year-old right-handed man who developed bilateral stereoagnosia after suffering a small infarct in the crown of the left postcentral gyrus...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28921611/dendritic-spines-provide-cognitive-resilience-against-alzheimer-s-disease
#10
Benjamin D Boros, Kelsey M Greathouse, Erik G Gentry, Kendall A Curtis, Elizabeth L Birchall, Marla Gearing, Jeremy H Herskowitz
OBJECTIVE: Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer's disease (AD) initiate years prior to clinical dementia onset. However some 30%-50% of older individuals that harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. We hypothesized that in cases with AD pathology structural changes in dendritic spines would distinguish individuals that had or did not have clinical dementia...
September 16, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28920767/auricular-vagal-nerve-stimulation-in-peripheral-arterial-disease-patients
#11
Gerald Hackl, Andreas Prenner, Philipp Jud, Franz Hafner, Peter Rief, Gerald Seinost, Ernst Pilger, Marianne Brodmann
BACKGROUND: Auricular nerve stimulation has been proven effective in different diseases. We investigated if a conservative therapeutic alternative for claudication in peripheral arterial occlusive disease (PAD) via electroacupuncture of the outer ear can be established. PATIENTS AND METHODS: In this prospective, double-blinded trial an ear acupuncture using an electroacupuncture device was carried out in 40 PAD patients in Fontaine stage IIb. Twenty patients were randomized to the verum group using a fully functional electroacupuncture device, the other 20 patients received a sham device (control group)...
September 18, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28918694/brain-metabolic-correlates-of-fatigue-in-parkinson-s-disease-a-pet-study
#12
Li Zhang, Tiannv Li, Yongsheng Yuan, Qing Tong, Siming Jiang, Min Wang, Jianwei Wang, Jian Ding, Qinrong Xu, Kezhong Zhang
The neural bases of fatigue in Parkinson's disease (PD) remain uncertain. We aimed to assess the brain metabolic correlates of fatigue in patients with PD. Twenty-seven PD patients without clinically relevant depression (17-item Hamilton Depression Rating Scale [HAMD] score ≥ 14), apathy (Apathy Scale [AS] score ≥ 14) and excessive daytime somnolence (Epworth Sleepiness Scale [ESS] score ≥ 10) were evaluated with Fatigue Severity Scale (FSS). Each patient had an F-18 fluorodeoxyglucose PET (FDG-PET) scan...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28904460/juvenile-myoclonic-epilepsy-with-frontal-executive-dysfunction-is-associated-with-reduced-gray-matter-volume-by-voxel-based-morphometry
#13
Sreeja H Pillai, Sheelakumari Raghavan, Mrudula Mathew, Geetha M Gopalan, Chandrasekharan Kesavadas, Sankara Sarma, Sanjeev V Thomas
OBJECTIVE: Frontal executive dysfunction (FED) and abnormalities in volumetric magnetic resonance imaging (MRI) have been described in juvenile myoclonic epilepsy (JME). We aimed to compare JME patients with and without FED by group analysis of voxel-based morphometric (VBM) estimates of brain volume in MRI. SUBJECTS AND METHODS: We studied frontal executive functions in patients with JME and analyzed the possible association of FED with their demographic, clinical, and electrographic characteristics...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28886620/2017-esc-guidelines-on-the-diagnosis-and-treatment-of-peripheral-arterial-diseases-in-collaboration-with-the-european-society-for-vascular-surgery-esvs-document-covering-atherosclerotic-disease-of-extracranial-carotid-and-vertebral-mesenteric-renal-upper-and
#14
Victor Aboyans, Jean-Baptiste Ricco, Marie-Louise E L Bartelink, Martin Björck, Marianne Brodmann, Tina Cohnert, Jean-Philippe Collet, Martin Czerny, Marco De Carlo, Sebastian Debus, Christine Espinola-Klein, Thomas Kahan, Serge Kownator, Lucia Mazzolai, A Ross Naylor, Marco Roffi, Joachim Röther, Muriel Sprynger, Michal Tendera, Gunnar Tepe, Maarit Venermo, Charalambos Vlachopoulos, Ileana Desormais
No abstract text is available yet for this article.
August 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28883789/static-and-dynamic-measures-of-human-brain-connectivity-predict-complementary-aspects-of-human-cognitive-performance
#15
Aurora I Ramos-Nuñez, Simon Fischer-Baum, Randi C Martin, Qiuhai Yue, Fengdan Ye, Michael W Deem
In cognitive network neuroscience, the connectivity and community structure of the brain network is related to measures of cognitive performance, like attention and memory. Research in this emerging discipline has largely focused on two measures of connectivity-modularity and flexibility-which, for the most part, have been examined in isolation. The current project investigates the relationship between these two measures of connectivity and how they make separable contribution to predicting individual differences in performance on cognitive tasks...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28870514/microstructure-informed-slow-diffusion-tractography-in-humans-enhances-visualisation-of-fibre-pathways
#16
Farida Grinberg, Ivan I Maximov, Ezequiel Farrher, N Jon Shah
Conventional fibre tractography methods based on diffusion tensor imaging exploit diffusion anisotropy and directionality in the range of low diffusion weightings (b-values). High b-value Biexponential Diffusion Tensor Analysis reported previously has demonstrated that fractional anisotropy of the slow diffusion component is essentially higher than that of conventional diffusion tensor imaging whereas popular compartment models associate this slow diffusion component with axonal water fraction. One of the primary aims of this study is to elucidate the feasibility and potential benefits of "microstructure-informed" whole-brain slow-diffusion fibre tracking (SDIFT) in humans...
September 1, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28864953/monitoring-of-genetically-modified-escherichia-coli-in-laboratory-wastewater
#17
Fabienne Wichmann, Ines Wyrsch, Jörg Frank, Matthias Müller, Nicole Bertschi, Peter Brodmann, Claudia Bagutti
Containment of genetically modified (GM) microorganisms such as Escherichia coli is a legal requirement to protect the environment from an unintended release and to avoid horizontal gene transfer (HGT) of recombinant DNA to native bacteria. In this study, we sampled the laboratory wastewater (LWW) at a large Swiss university from three sources over 2 years and cultured ampicillin-resistant, presumptive GM E. coli. From a total of 285 samples, 127 contained presumptive GM E. coli (45%) at a mean concentration of 2...
October 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28851596/2017-esc-guidelines-on-the-diagnosis-and-treatment-of-peripheral-arterial-diseases-in-collaboration-with-the-european-society-for-vascular-surgery-esvs
#18
Authors/Task Force Members, Victor Aboyans, Jean-Baptiste Ricco, Marie-Louise E L Bartelink, Martin Björck, Marianne Brodmann, Tina Cohnert, Jean-Philippe Collet, Martin Czerny, Marco De Carlo, Sebastian Debus, Christine Espinola-Klein, Thomas Kahan, Serge Kownator, Lucia Mazzolai, A Ross Naylor, Marco Roffi, Joachim Röther, Muriel Sprynger, Michal Tendera, Gunnar Tepe, Maarit Venermo, Charalambos Vlachopoulos, Ileana Desormais, Document Reviewers, Petr Widimsky, Philippe Kolh, Stefan Agewall, Héctor Bueno, Antonio Coca, Gert J De Borst, Victoria Delgado, Florian Dick, Cetin Erol, Marc Ferrini, Stavros Kakkos, Hugo A Katus, Juhani Knuuti, Jes Lindholt, Heinrich Mattle, Piotr Pieniazek, Massimo Francesco Piepoli, Dierk Scheinert, Horst Sievert, Iain Simpson, Jakub Sulzenko, Juan Tamargo, Lale Tokgozoglu, Adam Torbicki, Nikolaos Tsakountakis, José Tuñón, Melina Vega de Ceniga, Stephan Windecker, Jose Luis Zamorano
No abstract text is available yet for this article.
August 26, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28841675/neural-encoding-of-saltatory-pneumotactile-velocity-in-human-glabrous-hand
#19
Hyuntaek Oh, Rebecca Custead, Yingying Wang, Steven Barlow
Neurons in the somatosensory cortex are exquisitely sensitive to mechanical stimulation of the skin surface. The location, velocity, direction, and adaptation of tactile stimuli on the skin's surface are discriminable features of somatosensory processing, however the representation and processing of dynamic tactile arrays in the human somatosensory cortex are poorly understood. The principal aim of this study was to map the relation between dynamic saltatory pneumatic stimuli at discrete traverse velocities on the glabrous hand and the resultant pattern of evoked BOLD response in the human brain...
2017: PloS One
https://www.readbyqxmd.com/read/28822871/altered-language-network-in-benign-childhood-epilepsy-patients-with-spikes-from-non-dominant-side-a-resting-state-fmri-study
#20
Jiajia Fang, Sihan Chen, Cheng Luo, Qiyong Gong, Dongmei An, Dong Zhou
Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes, and language deficits associated with BECTS have become a hot topic. This study investigated alterations of the language network in BECTS children with spikes from the non-dominant side in comparison with healthy controls. Twenty-three children with BECTS and 20 age-matched healthy controls were enrolled. Region of interest -based whole brain functional connectivity analysis was used to identify the potential differences in the functional connectivity of the Broca's area between the two groups...
August 1, 2017: Epilepsy Research
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