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https://www.readbyqxmd.com/read/28101616/successful-retrieval-of-an-embolized-vascular-closure-device-angio-seal-%C3%A2-after-peripheral-angioplasty
#1
Philipp Jud, Rupert Portugaller, Dennis Bohlsen, Thomas Gary, Marianne Brodmann, Gerald Hackl, Franz Hafner
A 55-year-old male with peripheral arterial disease underwent angioplasty of the right lower limb arteries via antegrade femoral access. Angio-Seal(®) closure device was used to treat the puncture site, whereby the intravascular sealing anchor accidentally embolized into the malleolar region of the right posterior tibial artery. Successful retrieval of the anchor was accomplished by a SpiderFX embolic protection device. This technique may be a useful approach to retrieve embolized foreign bodies via endovascular access...
January 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28100246/genetic-effect-of-interleukin-1-beta-c-511t-polymorphism-on-the-structural-covariance-network-and-white-matter-integrity-in-alzheimer-s-disease
#2
Chi-Wei Huang, Shih-Wei Hsu, Shih-Jen Tsai, Nai-Ching Chen, Mu-En Liu, Chen-Chang Lee, Shu-Hua Huang, Weng-Neng Chang, Ya-Ting Chang, Wan-Chen Tsai, Chiung-Chih Chang
BACKGROUND: Inflammatory processes play a pivotal role in the degenerative process of Alzheimer's disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 beta gene has been significantly associated with differences in the secretory capacity of interleukin-1 beta. In this study, we investigated whether this functional polymorphism mediates the brain networks in patients with Alzheimer's disease. METHODS: We enrolled a total of 135 patients with Alzheimer's disease (65 males, 70 females), and investigated their gray matter structural covariance networks using 3D T1 magnetic resonance imaging and their white matter macro-structural integrities using fractional anisotropy...
January 18, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28081226/regional-homogeneity-changes-in-nicotine-addicts-by-resting-state-fmri
#3
Hongbo Chen, Shaofeng Mo
OBJECTIVE: To reveal the brain functional changes of nicotine addicts compared with those of non-smokers and explore the objective biomarker for nicotine dependence evaluation. METHODS: A total of 14 smokers and 11 non-smoking controls were recruited for this study. Resting-state functional magnetic resonance imaging and regional homogeneity (ReHo) were applied in the neural activity analysis. Two-sample t-test was performed to examine the voxel-wise difference between the smokers and the controls...
2017: PloS One
https://www.readbyqxmd.com/read/28045465/methylomic-profiling-of-cortex-samples-from-completed-suicide-cases-implicates-a-role-for-psors1c3-in-major-depression-and-suicide
#4
T M Murphy, B Crawford, E L Dempster, E Hannon, J Burrage, G Turecki, Z Kaminsky, J Mill
Major depressive disorder (MDD) represents a major social and economic health issue and constitutes a major risk factor for suicide. The molecular pathology of suicidal depression remains poorly understood, although it has been hypothesised that regulatory genomic processes are involved in the pathology of both MDD and suicidality. In this study, genome-wide patterns of DNA methylation were assessed in depressed suicide completers (n=20) and compared with non-psychiatric, sudden-death controls (n=20) using tissue from two cortical brain regions (Brodmann Area 11 (BA11) and Brodmann Area 25 (BA25))...
January 3, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28044021/individual-differences-in-visual-motion-perception-and-neurotransmitter-concentrations-in-the-human-brain
#5
Tatsuto Takeuchi, Sanae Yoshimoto, Yasuhiro Shimada, Takanori Kochiyama, Hirohito M Kondo
Recent studies have shown that interindividual variability can be a rich source of information regarding the mechanism of human visual perception. In this study, we examined the mechanisms underlying interindividual variability in the perception of visual motion, one of the fundamental components of visual scene analysis, by measuring neurotransmitter concentrations using magnetic resonance spectroscopy. First, by psychophysically examining two types of motion phenomena-motion assimilation and contrast-we found that, following the presentation of the same stimulus, some participants perceived motion assimilation, while others perceived motion contrast...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28043979/the-year-in-cardiology-2016-peripheral-circulation
#6
Marco De Carlo, Lucia Mazzolai, Eduardo Bossone, Marianne Brodmann, Antonio Micari, Maria Lorenza Muiesan, Jean-Baptiste Ricco, Eugenio Stabile, Giancarlo Agnelli, Victor Aboyans
No abstract text is available yet for this article.
January 2, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28034960/elevated-dna-oxidation-and-dna-repair-enzyme-expression-in-brain-white-matter-in-major-depressive-disorder
#7
Attila Szebeni, Katalin Szebeni, Timothy P DiPeri, Luke A Johnson, Craig A Stockmeier, Jessica D Crawford, Michelle J Chandley, Liza J Hernandez, Katherine C Burgess, Russell W Brown, Gregory A Ordway
BACKGROUND: Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. METHODS: Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n=10) and psychiatrically normal control donors (n=13). DNA oxidation was also measured in BA10 white matter of schizophrenia donors (n=10) and in prefrontal cortical white matter from control rats (n=8) and rats with repeated stress-induced anhedonia (n=8)...
December 29, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27999541/parahippocampal-cortex-mediates-the-relationship-between-lutein-and-crystallized-intelligence-in-healthy-older-adults
#8
Marta K Zamroziewicz, Erick J Paul, Chris E Zwilling, Elizabeth J Johnson, Matthew J Kuchan, Neal J Cohen, Aron K Barbey
Introduction: Although, diet has a substantial influence on the aging brain, the relationship between dietary nutrients and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between a carotenoid important for brain health across the lifespan, lutein, and crystallized intelligence in cognitively intact older adults. We hypothesized that higher serum levels of lutein are associated with better performance on a task of crystallized intelligence, and that this relationship is mediated by gray matter structure of regions within the temporal cortex...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27972283/economic-analysis-of-endovascular-interventions-for-the-treatment-of-femoropopliteal-peripheral-artery-disease-in-austria
#9
J B Pietzsch, B P Geisler, M R Jaff, T Zeller, M Brodmann
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970230/tct-839-acute-safety-and-technical-performance-evaluation-of-a-novel-cto-crossing-device-based-on-a-shock-wave-energized-guidewire
#10
Louis-Philippe Riel, Manuel Charlebois-Ménard, Steven Dion, Stéphane Rinfret, Jean-Franà Ois Tanguay, Marie-Élaine Clavet, Marie-Jeanne Bertrand, Pascale Geoffroy, Simon Berube, Marc-Antoine Despatis, Marianne Brodmann, Éric Thérèse, Andrew Benko, Louis-Georges Guy, Guy LeClerc, Madeleine Chagnon, Martin Brouillette
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970173/tct-786-6-month-duplex-patency-and-mra-following-oct-guided-atherectomy-single-center-prospective-case-series
#11
Marianne Brodmann
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970164/tct-777-safety-and-performance-of-the-shockwave-medical-lithoplasty%C3%A2-system-in-treating-calcified-peripheral-vascular-lesions-6-month-results-from-the-two-phase-disrupt-pad-study
#12
Todd Brinton, Marianne Brodmann, Martin Werner, Gunnar Tepe, Andrew Holden, Dierk Scheinert, Florian Wolf, Giovanni Torsello, Alexandra Lansky, Michael Jaff, Thomas Zeller
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27939794/studying-cyto-and-myeloarchitecture-of-the-human-cortex-at-ultra-high-field-with-quantitative-imaging-r1-r2-and-magnetic-susceptibility
#13
José P Marques, Diana Khabipova, Rolf Gruetter
In this manuscript, the use of quantitative imaging at ultra-high field is evaluated as a mean to study cyto and myelo-architecture of the cortex. The quantitative contrasts used are the longitudinal relaxation rate (R1), apparent transverse relaxation rate (R2(*)) and quantitative susceptibility mapping (QSM). The quantitative contrasts were computed using high resolution in-vivo (0.65mm isotropic) brain data acquired at 7T. The performance of the different quantitative approaches was evaluated by visualizing the contrast between known highly myelinated primary sensory cortex regions and the neighbouring cortex...
December 7, 2016: NeuroImage
https://www.readbyqxmd.com/read/27932883/functional-cortical-changes-in-relapsing-remitting-multiple-sclerosis-at-amplitude-configuration-a-resting-state-fmri-study
#14
Heng Liu, Hua Chen, Bo Wu, Tijiang Zhang, Jinhui Wang, Kexin Huang, Ganjun Song, Jian Zhan
OBJECTIVE: The aim of this study was to explore the amplitude of spontaneous brain activity fluctuations in patients with relapsing-remitting multiple sclerosis (RRMS) using the amplitude of low-frequency fluctuation (ALFF) method. METHODS: ALFF and SPM8 were utilized to assess alterations in regional spontaneous brain activities in patients with RRMS in comparison with healthy controls (HCs). The beta values of altered brain regions between patients with RRMS and HCs were extracted, and a receiver operating characteristic (ROC) curve was generated to calculate the sensitivities and specificities of these different brain areas for distinguishing patients with RRMS from HCs...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27929395/deficiency-in-the-ubiquitin-conjugating-enzyme-ube2a-in-alzheimer-s-disease-ad-is-linked-to-deficits-in-a-natural-circular-mirna-7-sponge-circrna-cirs-7
#15
Yuhai Zhao, Peter N Alexandrov, Vivian Jaber, Walter J Lukiw
Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve. Circular RNAs (circRNAs), a recently discovered class of ssRNA enriched in the brain and retina, are extremely stable and intrinsically resilient to degradation by exonuclease. Conventional methods of ssRNA, microRNA (miRNA), or messenger RNA (mRNA) detection and quantitation requiring free ribonucleotide ends may have considerably underestimated the quantity and significance of CNS circRNA in the CNS...
December 5, 2016: Genes
https://www.readbyqxmd.com/read/27899123/a-functional-magnetic-resonance-imaging-investigation-of-visual-hallucinations-in-the-human-striate-cortex
#16
Hina Abid, Fayyaz Ahmad, Soo Y Lee, Hyun W Park, Dongmi Im, Iftikhar Ahmad, Safee U Chaudhary
PURPOSE: Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions remain poorly understood. Towards this goal, in this work, we aim to correlate the human ocular perceptions with visual hallucinations, and map them to their cerebral origins. METHODS: An fMRI study was performed to examine the visual cortical areas including the striate, parastriate and peristriate cortex in the occipital lobe of the human brain...
November 29, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27899117/assistive-products-and-the-sustainable-development-goals-sdgs
#17
Emma Tebbutt, Rebecca Brodmann, Johan Borg, Malcolm MacLachlan, Chapal Khasnabis, Robert Horvath
The Sustainable Development Goals (SDGs) have placed great emphasis on the need for much greater social inclusion, and on making deliberate efforts to reach marginalized groups. People with disabilities are often marginalized through their lack of access to a range of services and opportunities. Assistive products can help people overcome impairments and barriers enabling them to be active, participating and productive members of society. Assistive products are vital for people with disabilities, frailty and chronic illnesses; and for those with mental health problems, and gradual cognitive and physical decline characteristic of aging populations...
November 29, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27884212/angiotensin-converting-enzyme-2-is-reduced-in-alzheimer-s-disease-in-association-with-increasing-amyloid-%C3%AE-and-tau-pathology
#18
Patrick Gavin Kehoe, Steffenny Wong, Noura Al Mulhim, Laura Elyse Palmer, J Scott Miners
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II to angiotensin 1-7 (Ang (1-7)) and counter-regulates the classical axis of RAS. We have investigated the expression and distribution of ACE-2 in post-mortem human brain tissue in relation to AD pathology and classical RAS axis activity...
November 25, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27882449/diametrical-relationship-between-gray-and-white-matter-volumes-in-autism-spectrum-disorder-and-schizophrenia
#19
Serge A Mitelman, Marie-Cecile Bralet, M Mehmet Haznedar, Eric Hollander, Lina Shihabuddin, Erin A Hazlett, Monte S Buchsbaum
Autism spectrum disorders and schizophrenia have been variously characterized as separate nosological entities with overlapping deficits in social cognition or diametrical extremes of a phenotypic continuum. This study aimed to determine how these models apply to comparative morphometric data. MRI scans of the brain were obtained in 49 subjects with schizophrenia, 20 subjects with autism and 39 healthy controls. Images were parcellated into 40 Brodmann areas and entered into repeated-measures ANOVA for between-group comparison of global and localized gray and white matter volumes...
November 23, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27873015/muscarinic-receptor-binding-changes-in-postmortem-parkinson-s-disease
#20
Caitlin McOmish, Geoff Pavey, Catriona McLean, Malcolm Horne, Brian Dean, Elizabeth Scarr
Parkinson's disease (PD) is a devastating disorder, affecting approximately 2% of people aged 60 and above. It is marked by progressive neurodegeneration that has long been known to impact dopaminergic cells and circuits, but more recently the acetylcholine system has also been implicated in the complex aetiology and symptomatology of the disease. While broad changes in cholinergic markers have been described, insight into the contribution of specific acetylcholine receptors is less clear. To address this important unknown, in this study we performed [(3)H] pirenzepine, [(3)H] 4DAMP, and [(3)H] AF-DX 384 in situ radioligand binding on postmortem tissues from Brodmann's area 6, 9, 46, and the caudate putamen, from PD and matched controls to detect muscarinic M1, M3, and M1/2/4 receptors, respectively...
November 21, 2016: Journal of Neural Transmission
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