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https://www.readbyqxmd.com/read/28705939/changes-in-pulmonary-exercise-haemodynamics-in-scleroderma-a-4-year-prospective-study
#1
Gabor Kovacs, Alexander Avian, Nora Wutte, Franz Hafner, Florentine Moazedi-Fürst, Sonja Kielhauser, Elisabeth Aberer, Marianne Brodmann, Winfried Graninger, Vasile Foris, Andrea Olschewski, Horst Olschewski
Pulmonary arterial hypertension (PAH) is a feared complication of systemic sclerosis. In this prospective cohort study, we monitored the changes in resting and exercise pulmonary haemodynamics of scleroderma patients without initial PAH over a mean follow-up period of ∼4 years.All patients underwent exercise echocardiography and cardiopulmonary exercise testing at baseline and follow-up. A subgroup underwent exercise right heart catheter (RHC) investigations. The primary end-point was the echocardiographic systolic pulmonary arterial pressure at 50 W exercise (sPAP50)...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28692408/preliminary-findings-of-altered-functional-connectivity-of-the-default-mode-network-linked-to-functional-outcomes-one-year-after-pediatric-traumatic-brain-injury
#2
Jaclyn A Stephens, Cynthia F Salorio, Anita D Barber, Sarah R Risen, Stewart H Mostofsky, Stacy J Suskauer
PURPOSE AND METHOD: This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). RESULTS: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks...
July 10, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28668692/wastewater-is-a-reservoir-for-clinically-relevant-carbapenemase-and-16s-rrna-methylase-producing-enterobacteriaceae
#3
Katrin Zurfluh, Claudia Bagutti, Peter Brodmann, Monica Alt, Jürg Schulze, Séamus Fanning, Roger Stephan, Magdalena Nüesch-Inderbinen
The aim of the study was to evaluate wastewater for carbapenemase producing Enterobacteriaceae (CPE) and 16S rRNA methylase producing Gram negative bacteria (MPB), and to assess their occurrence following wastewater treatment. Wastewater samples were collected between June 2015 and March 2016 in the sewage network of the city of Basel from sites located before and after influx of wastewater from the hospital into the sewage network. Samples were also obtained from the influent and from the effluent of the receiving wastewater treatment plant...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28658047/a-magnetoencephalography-investigation-of-coherence-source-imaging-in-panic-disorder
#4
Nash N Boutros, Seung-Suk Kang, Kathleen M Gustafson, Zach Thomas, Kemal Sagduyu, Jocelyn Pearson, Susan M Bowyer
Limbic and frontal structures are largely implicated in panic disorder (PD). Decreased coherence imaging values, as determined by magnetoencephalography (MEG), are suggestive of decreased or inefficient communication among these structures. We have previously demonstrated that coherence source imaging (CSI) values could be similar or higher in some PD patients. The purpose of the current investigation was to replicate these finding in a larger sample. Nine strictly diagnosed PD patients and nine age-matched and sex-matched healthy controls were examined...
June 27, 2017: Neuroreport
https://www.readbyqxmd.com/read/28642285/state-dependent-tms-reveals-representation-of-affective-body-movements-in-the-anterior-intraparietal-cortex
#5
Noemi Mazzoni, Christianne Jacobs, Paola Venuti, Juha Silvanto, Luigi Cattaneo
In humans, recognition of others' actions involves a cortical network that comprises, among other cortical regions, the posterior superior temporal sulcus (pSTS), where biological motion is coded and the anterior intraparietal suclus (aIPS), where movement information is elaborated in terms of meaningful goal-directed actions. This action observation system (AOS) is thought to encode neutral voluntary actions, and possibly some aspects of affective motor repertoire, but the role of the AOS' areas in processing affective kinematic information has never been examined...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28638030/-characteristics-of-cerebral-glucose-metabolism-in-patients-with-cognitive-impairment-in-parkinson-s-disease
#6
Ju G Homenko, D S Susin, G V Kataeva, Ju A Irishina, I G Zavolokov
AIM: To study the relationship between early cognitive impairment symptoms and cerebral glucose metabolism in different brain regions (according to the positron emission tomography (PET) data) in Parkinson's disease (PD) in order to increase the diagnostic and treatment efficacy. MATERIAL AND METHODS: Two groups of patients with PD (stage I-III), including 11 patients without cognitive disorders and 13 with mild cognitive impairment (MCI), were examined. The control group included 10 age-matched people with normal cognition...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28629975/anatomical-and-functional-properties-of-the-foot-and-leg-representation-in-areas-3b-1-and-2-of-primary-somatosensory-cortex-in-humans-a-7t-fmri-study
#7
Michel Akselrod, Roberto Martuzzi, Andrea Serino, Wietske van der Zwaag, Roger Gassert, Olaf Blanke
Primary somatosensory cortex (S1) processes somatosensory information and is composed of multiple subregions. In particular, tactile information from the skin is encoded in three subregions, namely Brodmann areas (BAs) 3b, 1 and 2, with each area representing a complete map of the contralateral body. Although, much is known about the somatotopic organization of the hand in human S1, less research has been carried out regarding the somatotopic maps of the foot and leg in S1. Moreover, a latero-medial S1 organization along the superior part of the postcentral gyrus has been reported when moving from hip to toes, yet to date there is no study investigating leg/foot maps within the different subregions of S1...
June 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28621333/francisella-requires-dynamic-type-vi-secretion-system-and-clpb-to-deliver-effectors-for-phagosomal-escape
#8
Maj Brodmann, Roland F Dreier, Petr Broz, Marek Basler
Francisella tularensis is an intracellular pathogen that causes the fatal zoonotic disease tularaemia. Critical for its pathogenesis is the ability of the phagocytosed bacteria to escape into the cell cytosol. For this, the bacteria use a non-canonical type VI secretion system (T6SS) encoded on the Francisella pathogenicity island (FPI). Here we show that in F. novicida T6SS assembly initiates at the bacterial poles both in vitro and within infected macrophages. T6SS dynamics and function depends on the general purpose ClpB unfoldase, which specifically colocalizes with contracted sheaths and is required for their disassembly...
June 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28604057/heterogeneity-of-d-serine-distribution-in-the-human-central-nervous-system
#9
Masataka Suzuki, Nobuaki Imanishi, Masashi Mita, Kenji Hamase, Sadakazu Aiso, Jumpei Sasabe
D-serine is an endogenous ligand for N-methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human neurophysiology. However, distribution and regulation of D-serine in humans are not well understood. Here, we found that D-serine is heterogeneously distributed in the human central nervous system (CNS). The cerebrum contains the highest level of D-serine among the areas in the CNS...
May 2017: ASN Neuro
https://www.readbyqxmd.com/read/28596726/ability-to-gain-control-over-one-s-own-brain-activity-and-its-relation-to-spiritual-practice-a-multimodal-imaging-study
#10
Silvia E Kober, Matthias Witte, Manuel Ninaus, Karl Koschutnig, Daniel Wiesen, Gabriela Zaiser, Christa Neuper, Guilherme Wood
Spiritual practice, such as prayer or meditation, is associated with focusing attention on internal states and self-awareness processes. As these cognitive control mechanisms presumably are also important for neurofeedback (NF), we investigated whether people who pray frequently (N = 20) show a higher ability of self-control over their own brain activity compared to a control group of individuals who rarely pray (N = 20). All participants underwent structural magnetic resonance imaging (MRI) and one session of sensorimotor rhythm (SMR, 12-15 Hz) based NF training...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28560810/changes-of-cortical-activation-in-swallowing-following-high-frequency-repetitive-transcranial-magnetic-stimulation-in-older-adults
#11
J-W Park, G-J Sim, H-J Kim, J-S Yeo, H-J Hong, B S Kwon
BACKGROUND: This study explored whether high-frequency repetitive transcranial magnetic stimulation (rTMS) can induce positive changes in the cortical areas of older adults who do not have functional difficulties in swallowing. METHODS: Ten healthy, right-handed, elderly volunteers were subjected to 18F-labeled fluorodeoxyglucose positron emission tomography(FDG-PET) scans when at rest, swallowing before rTMS, and swallowing after rTMS. During the swallowing study, water was infused orally via a catheter at a rate of 600 mL/h...
May 31, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28560268/learning-stable-and-predictive-network-based-patterns-of-schizophrenia-and-its-clinical-symptoms
#12
Mina Gheiratmand, Irina Rish, Guillermo A Cecchi, Matthew R G Brown, Russell Greiner, Pablo I Polosecki, Pouya Bashivan, Andrew J Greenshaw, Rajamannar Ramasubbu, Serdar M Dursun
Schizophrenia is often associated with disrupted brain connectivity. However, identifying specific neuroimaging-based patterns pathognomonic for schizophrenia and related symptom severity remains a challenging open problem requiring large-scale data-driven analyses emphasizing not only statistical significance but also stability across multiple datasets, contexts and cohorts. Accurate prediction on previously unseen subjects, or generalization, is also essential for any useful biomarker of schizophrenia. In order to build a predictive model based on functional network feature patterns, we studied whole-brain fMRI functional networks, both at the voxel level and lower-resolution supervoxel level...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28560265/isoform-specific-differences-in-phospholipase-c-beta-1-expression-in-the-prefrontal-cortex-in-schizophrenia-and-suicide
#13
M Udawela, E Scarr, S Boer, J Y Um, A J Hannan, C McOmish, C C Felder, E A Thomas, B Dean
Our previous study demonstrated that phospholipase C beta 1 mRNA was down-regulated in Brodmann's area 46 from subjects with schizophrenia. However, phospholipase C beta 1 protein has also been shown to be lower in Brodmann's area 8 and 9 from teenage suicide subjects, creating a potential confound in interpreting the findings in schizophrenia due to the high suicide rate associated with this disorder. To begin to reconcile and consolidate these findings, in this study, we measured mRNA and protein levels of phospholipase C beta 1 variants a and b in Brodmann's area 46 and Brodmann's area 9 from subjects with schizophrenia, many of whom were suicide completers, and determined the diagnostic specificity of observed findings...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28545486/depression-in-patients-with-sapho-syndrome-and-its-relationship-with-brain-activity-and-connectivity
#14
Jie Lu, Yanping Duan, Zhentao Zuo, Wenrui Xu, Xuewei Zhang, Chen Li, Rong Xue, Hanzhang Lu, Weihong Zhang
BACKGROUND: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disease and there is no related literature concerning psychiatric symptoms in SAPHO patients. Thus, we believe that this will be the first paper to explore the episode and the neurobiological basis of depression symptoms in SAPHO patients using resting state functional magnetic resonance imaging (rs-fMRI). Twenty-eight SAPHO patients and fifteen age- and gender- matched normal controls (NC) were consecutively submitted to psychiatric evaluation and rs-fMRI scanning...
May 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28533613/the-effects-of-tool-holding-on-body-schema-during-motor-imagery-a-near-infrared-spectroscopy-study
#15
Tsubasa Oikawa, Daisuke Hirano, Takamichi Taniguchi, Hitoshi Maruyama
[Purpose] The purpose of this study is to assess the influence of tool holding on brain activities during motor imagery in two tasks: imagining the movement of writing the alphabet while holding a pen and without holding the pen. [Subjects and Methods] Eleven healthy right-handed adults performed two tasks, holding a pen and not holding the pen during imagining the movement of writing the alphabet using a pen. Regions of targets were Brodmann areas 6 which were a motor-related region, 44/45 and 39/40 which taken on the role of forming the body schema...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28521147/a-pilot-study-of-differential-brain-activation-to-suicidal-means-and-dna-methylation-of-cacna1c-gene-in-suicidal-attempt-patients
#16
Young Jong Kim, Hae Jeong Park, Geon-Ho Jahng, Sang Min Lee, Won Sub Kang, Su Kang Kim, Tae Kim, Ah Rang Cho, Jin Kyung Park
Suicide is a serious public health problem. In this study, we investigated functional brain changes to novel visual stimuli of suicidal means, DNA methylation status, and the relationship between the two markers. 14 suicidal attempt patients (SAs) and 22 healthy controls were included. Pictures of facial expressions and suicidal means were shown to subjects during fMRI scanning. 11 CpG sites within transcription factor binding site of CACNA1C gene were selected. In knives (K) vs. natural landscape (NL) condition, left middle frontal gyrus (Brodmann's area, BA 6 and 46) and left inferior frontal gyrus (BA 9) were shown to be significantly higher brain activation in the SAs than the controls (p<0...
May 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28516901/eeg-source-space-analysis-of-the-supervised-factor-analytic-approach-for-the-classification-of-multi-directional-arm-movement
#17
Vikram Shenoy Handiru, A P Vinod, Cuntai Guan
OBJECTIVE: In electroencephalography (EEG)-based brain-computer interface (BCI) systems for motor control tasks the conventional practice is to decode motor intentions by using scalp EEG. However, scalp EEG only reveals certain limited information about the complex tasks of movement with a higher degree of freedom. Therefore, our objective is to investigate the effectiveness of source-space EEG in extracting relevant features that discriminate arm movement in multiple directions. APPROACH: We have proposed a novel feature extraction algorithm based on supervised factor analysis that models the data from source-space EEG...
May 18, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28506483/cortical-and-subcortical-functional-neuroanatomy-for-low-grade-glioma-surgery
#18
REVIEW
L Chenin, M Lefranc, S Velut, P Foulon, E Havet, J Peltier
Knowledge of the encephalon anatomy is crucial for neurosurgical practice, especially the main cortical functional structures and their connections. General organisation of the encephalon is presented with frontal, parietal, occipital, temporal, limbic and insular lobes and their Brodmann correspondence. Secondly, subcortical anatomy will be presented with main white matter fasciculi in three separated categories: association, commissural and projection fibers. Main association fibers are inferior occipitofrontal fasciculus, superior longitudinal fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, uncinate fasciculus, and cingulum...
May 12, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28495501/semen-modulated-secretory-activity-of-oviductal-epithelial-cells-is-linked-to-cellular-proteostasis-network-remodeling-proteomic-insights-into-the-early-phase-of-interaction-in-the-oviduct-in-vivo
#19
Birgit Steinberger, Hans Yu, Theodor Brodmann, Daniela Milovanovic, Ursula Reichart, Urban Besenfelder, Konstantin Artemenko, Ebrahim Razzazi-Fazeli, Gottfried Brem, Corina Mayrhofer
The oviductal epithelium is crucial for the integrity of the female organ. Previously we got evidence that the surface proteome of oviductal epithelial cells (Oecs) is promptly altered in response to insemination and thus suggested that this early phase plays a notable regulatory role in maintaining cellular function. This study further aimed to assess the effect of semen on the cellular and molecular mechanisms in rabbit Oecs. A quantitative gel-based proteomic approach was applied to analyze changes at three time points (0h, 1h, 2h) after intrauterine insemination (IUI) compared to time matched controls...
May 8, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28476335/abnormal-gene-and-protein-expression-of-inflammatory-cytokines-in-the-postmortem-brain-of-schizophrenia-patients
#20
Ghanshyam N Pandey, Hooriyah S Rizavi, Hui Zhang, Xinguo Ren
Immune function abnormalities have been implicated in the pathophysiology of schizophrenia (SZ). This is primarily based on the observation that the levels of proinflammatory cytokines are significantly increased in the serum of SZ patients compared with normal control (NC) subjects. However, it is not known if similar cytokines abnormalities are also present in the brain of SZ patients. To further examine the involvement of inflammatory cytokines in the brain of SZ patients, we determined the protein and mRNA levels of TNF-α, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-13, LTA and IL-1RA in the prefrontal cortex (PFC, Brodmann area 9) of SZ patients...
May 2, 2017: Schizophrenia Research
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