Sthephanie Yannin Hernández-de la Cruz, Thania Ordaz-Robles, Marco Antonio Villaldama-Soriano, Cristian Emmanuel Luna-Guzmán, Tomas Almeida-Becerril, Judith Villa-Morales, Alan Cárdenas-Conejo, Eugenia Dolores Ruíz-Cruz, Jorge Maldonado-Hernandez, Mariela Bernabe-Garcia, Lourdes Barbosa-Cortés, Maricela Rodríguez-Cruz
BACKGROUND: In Duchenne muscular dystrophy (DMD), the immune system cells (ISC) synthesize molecules to regulate inflammation, a process needed to regenerate muscle. The relationship between those molecules and the muscle injury is unknown. Monocytes belonging to ISC are regulated by omega-3 fatty acids (ω-3 LCPUFAs) in DMD, but whether those fatty acids influence other ISC like T-cells is unknown. OBJECTIVE: We analyzed the expression of the muscle regeneration markers (FOXP3 and AREG) in circulating leukocytes of DMD patients with different lower limb muscle functions and whether ω-3 LCPUFAs regulate the expression of those markers, and the populations of circulating T-cells, their intracellular cytokines, and disease progression (CD69 and CD49d) markers...
February 21, 2024: Brain & Development