keyword
https://read.qxmd.com/read/38450069/case-report-and-literature-review-acute-rhabdomyolysis-caused-by-overheating-of-electric-blanket-complicated-with-guillain-barr%C3%A3-syndrome
#21
Dongyang Jiang, Ming Zhao, Xiaojun Li, Qiongdan Hu, Qiong Zhang
Rhabdomyolysis (RM) induced by electric blankets is exceedingly rare, with only three cases identified in our literature review. Both RM and Guillain-Barré syndrome (GBS) present with similar clinical manifestations of myalgia and muscle weakness, posing a potential challenge for accurate diagnosis in clinical settings. This report presents the case of a 22-year-old man who developed RM subsequent to the use of an electric blanket. Despite undergoing plasma exchange and renal replacement therapy, the patient continued to exhibit poor muscle strength in both lower limbs...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38448545/generalizable-anchor-aptamer-strategy-for-loading-nucleic-acid-therapeutics-on-exosomes
#22
JOURNAL ARTICLE
Gang Han, Yao Zhang, Li Zhong, Biaobiao Wang, Shuai Qiu, Jun Song, Caorui Lin, Fangdi Zou, Jingqiao Wu, Huanan Yu, Chao Liang, Ke Wen, Yiqi Seow, HaiFang Yin
Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and cellular internalization. Exosomes show potential as ideal delivery vehicles. However, an affordable generalizable system for efficient loading of oligonucleotides on exosomes remain lacking. Here, we identified an Exosomal Anchor DNA Aptamer (EAA) via SELEX against exosomes immobilized with our proprietary CP05 peptides. EAA shows high binding affinity to different exosomes and enables efficient loading of nucleic acid drugs on exosomes...
March 6, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38447941/-current-approach-in-the-follow-up-treatment-of-joint-preserving-operations-on-the-knee-joint-in-german-speaking-countries
#23
JOURNAL ARTICLE
Hannes Degenhardt, Anja Hirschmüller, Philipp Minzlaff
INTRODUCTION: Postoperative follow-up after joint-preserving knee surgery involves conventional physiotherapy as well as other approaches and devices such as CPM and CAM splints, TENS devices, BFR exercise, prehabilitation, and digital health applications. The aim of this survey was to investigate current standards, trends and control methods in postoperative care to identify fields of concern and to compare them with the current literature. MATERIAL AND METHODS: We conducted a structured anonymous online survey of specialists in orthopaedics and trauma surgery listed by the German-speaking Society for Arthroscopy and Joint Surgery (AGA)...
March 2024: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://read.qxmd.com/read/38436872/a-case-of-duchenne-muscular-dystrophy-recovered-from-prolonged-ischemic-kidney-injury-which-emerged-with-a-normal-creatinine-level
#24
JOURNAL ARTICLE
Kensuke Daikoku, Hinako Kondo, Masataka Kudo, Akira Sugiura
Duchenne muscular dystrophy (DMD) is an inherited disease characterized by progressive degeneration of the skeletal muscles. Renal dysfunction in patients with DMD has recently become more apparent as life expectancy has increased owing to advances in respiratory devices and heart failure therapies. A 23-year-old man with DMD who required nasal tube feeding was referred to our hospital with a 4-month history of renal dysfunction and anemia. The patient's serum creatinine (sCr) level was within the normal range (0...
March 4, 2024: CEN Case Reports
https://read.qxmd.com/read/38431830/network-pharmacology-analysis-and-clinical-efficacy-of-the-traditional-chinese-medicine-bu-shen-jian-pi-part%C3%A2-3-alleviation-of-hypoxia-muscle-wasting-and-modulation-of-redox-functions-in-amyotrophic-lateral-sclerosis
#25
JOURNAL ARTICLE
Rui Li, Xiaojing Han, Qiudong Wang, Chenghui Wang, Wei Jing, Haihan Zhang, Jun Wang, Weidong Pan
OBJECTIVE: The aim of this clinical study is to obtain evidence for the clinical efficacy of Bu-Shen-Jian-Pi formula (BSJP), a traditional Chinese medicine, used for the treatment of amyotrophic lateral sclerosis, a relatively rare, progressive and usually fatal disease possibly associated with alterations in tissue redox status, hypoxia, and muscular injury. BACKGROUND: The active agents in BSJP formula† causing apoptosis, modulation of redox changes, and alterations in the immune status have been studied previously by us using cell cultures...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38429046/surgical-excision-of-burn-wounds
#26
REVIEW
Anjali C Raghuram, Guy M Stofman, Jenny A Ziembicki, Francesco M Egro
Burn injuries affect patients of all ages, and timely surgical debridement and excision commence to protect dermal vascularity and integrity, improve healing, and minimize scarring. Several tools may be used for burn wound excision, which is performed either tangentially or down to muscular fascia. Once wounds are optimized from a tissue viability and healing standpoint, coverage may be obtained through grafts or secondary intention healing for more superficial injuries. A collaborative team of plastic and general surgeons, anesthesiologists, nutritionists, and therapists can provide improved patient care throughout the perioperative period, leading to improvements in overall patient morbidity and mortality...
April 2024: Clinics in Plastic Surgery
https://read.qxmd.com/read/38420088/medial-patellofemoral-ligament-reconstruction-a-case-report-for-an-integrated-rehabilitation-approach
#27
Abhishek Gujar, Pratik R Jaiswal, Swapnil U Ramteke
Medial patellofemoral ligament (MPFL) reconstruction is a surgical treatment, primarily indicated for patients grappling with recurrent patellar instability stemming from traumatic injury or underlying anatomical anomalies. This abstract aims to elucidate the indispensable role of physiotherapy in the post-operative rehabilitation trajectory for individuals subjected to MPFL reconstruction. Physiotherapy emerges as a linchpin in securing a triumphant outcome, fostering the healing of patellar stability, augmentation of range of motion (ROM), and bolstering muscular strength while concurrently mitigating potential complications...
January 2024: Curēus
https://read.qxmd.com/read/38419818/design-and-assessment-of-a-reconfigurable-behavioral-assistive-robot-a-pilot-study
#28
JOURNAL ARTICLE
Enming Shi, Wenzhuo Zhi, Wanxin Chen, Yuhang Han, Bi Zhang, Xingang Zhao
INTRODUCTION: For patients with functional motor disorders of the lower limbs due to brain damage or accidental injury, restoring the ability to stand and walk plays an important role in clinical rehabilitation. Lower limb exoskeleton robots generally require patients to convert themselves to a standing position for use, while being a wearable device with limited movement distance. METHODS: This paper proposes a reconfigurable behavioral assistive robot that integrates the functions of an exoskeleton robot and an assistive standing wheelchair through a novel mechanism...
2024: Frontiers in Neurorobotics
https://read.qxmd.com/read/38419520/ultrasound-guided-intraoral-botulinum-toxin-injection-into-the-lateral-pterygoid-muscle-for-chronic-temporomandibular-joint-dislocation
#29
Sung-Tak Lee, Dohyoung Kim, Jae-Hyeong Park, Tae-Geon Kwon
OBJECTIVES: Botulinum toxin type A (BTX), a powerful neurotoxin, can be an effective treatment choice for diverse muscular disorders and can reduce abnormal muscle activities. Abnormal movements of the mandible can be caused by involuntary and uncontrolled contractions of the lateral pterygoid muscle (LP) in various pathological situations. Previous reports have shown that BTX can reduce abnormal contractions of the LP. However, needle placement into the LP for BTX injection requires skill, experience, and sufficient anatomical knowledge...
February 29, 2024: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://read.qxmd.com/read/38416451/the-training-and-tapering-practices-of-highland-games-heavy-event-athletes
#30
JOURNAL ARTICLE
Paul W Winwood, Justin W L Keogh, S Kyle Travis, Ian Grieve, Hayden J Pritchard
Winwood, PW, Keogh, JW, Travis, SK, Grieve, I, and Pritchard, HJ. The training and tapering practices of Highland Games heavy event athletes. J Strength Cond Res 38(3): e116-e124, 2024-This study provides the first empirical evidence of how Highland Games heavy event athletes train and taper for Highland Games competitions. Athletes (n = 169) (mean ± SD: age 40.8 ± 10.7 years, height 181.2 ± 9.5 cm, weight 107.2 ± 23.0 kg, 18.8 ± 10.3 years of general resistance training, and 8.1 ± 6...
March 1, 2024: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38406840/higher-eccentric-hamstring-muscle-fatigue-after-participation-in-a-soccer-match-in-young-female-athletes
#31
JOURNAL ARTICLE
Sebastiano Nutarelli, Jacopo Emanuele Rocchi, Manuela Salerno, Alessandro Sangiorgio, Luca Deabate, Giuseppe Filardo
BACKGROUND: Hamstring (HS) strength deficits and imbalances have been identified as risk factors for sustaining anterior cruciate ligament (ACL) injuries and muscular strains, with HS injuries being the most prevalent muscle injuries in soccer athletes. The aim of this study was to investigate HS eccentric strength before and after a soccer match in both male and female soccer athletes. HYPOTHESIS: Soccer athletes have changes in eccentric HS strength after a soccer game...
February 26, 2024: Sports Health
https://read.qxmd.com/read/38406779/role-of-kinetic-chain-in-sports-performance-and-injury-risk-a-narrative-review
#32
REVIEW
Haifa Saleh Almansoof, Shibili Nuhmani, Qassim Muaidi
The kinetic chain refers to the body's intricate coordination of various segments to perform a specific activity involving precise positioning, timing, and speed. This process is based on task-oriented and activity-specific pre-programmed muscle activation patterns enhanced by repeated practice. It demands muscular eccentric strength, joint flexibility, and musculotendinous elastic energy storage. The body core (lumbopelvic-hip complex) forms the kinetic chains' central point of activities in most sports because it facilitates load transfers to and from the limbs...
November 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38398721/production-of-proliferation-and-differentiation-competent-porcine-myoblasts-for-preclinical-studies-in-a-porcine-large-animal-model-of-muscular-insufficiency
#33
JOURNAL ARTICLE
Jasmin Knoll, Bastian Amend, Tanja Abruzzese, Niklas Harland, Arnulf Stenzl, Wilhelm K Aicher
Muscular insufficiency is observed in many conditions after injury, chronic inflammation, and especially in elderly populations. Causative cell therapies for muscle deficiencies are not state of the art. Animal models to study the therapy efficacy are, therefore, needed. We developed an improved protocol to produce myoblasts suitable for pre-clinical muscle therapy studies in a large animal model. Myoblasts were isolated from the striated muscle, expanded by employing five different protocols, and characterized on transcript and protein expression levels to determine procedures that yielded optimized regeneration-competent myoblasts and multi-nucleated myotubes...
January 31, 2024: Life
https://read.qxmd.com/read/38391136/clinical-outcomes-of-rhabdomyolysis-validation-of-mcmahon-score-for-risk-prediction
#34
JOURNAL ARTICLE
Manju Mathew, Subhash Chandran Bhaskaran Pillai
BACKGROUND OBJECTIVES: Rhabdomyolysis in tropics has a unique aetiology and clinical profile. The objective of this study was to determine the aetiology and clinical outcomes of rhabdomyolysis and validate the McMahon risk prediction score in affected individuals from south India. METHODS: A retrospective study of affected individuals with rhabdomyolysis admitted to a tertiary care hospital in south India, between January 2015 and June 2020, was undertaken. In-patients who were ≥15 yr in age and had creatinine phosphokinase ≥5000 U/l were included in the study...
February 22, 2024: Indian Journal of Medical Research
https://read.qxmd.com/read/38389143/assessments-of-individual-fiber-glycogen-and-mitochondrial-volume-percentages-reveal-a-graded-reduction-in-muscle-oxidative-power-during-prolonged-exhaustive-exercise
#35
JOURNAL ARTICLE
Joachim Nielsen, Rasmus Jensen, Niels Ørtenblad
During submaximal exercise, there is a heterogeneous recruitment of skeletal muscle fibers, with an ensuing heterogeneous depletion of muscle glycogen both within and between fiber types. Here, we show that the mean (95% CI) mitochondrial volume as a percentage of fiber volume of non-glycogen-depleted fibers was 2 (-10:6), 5 (-21:11), and 12 (-21:-2)% lower than all the sampled fibers after continuing exercise for 1, 2 h, and until task failure, respectively. Therefore, a glycogen-dependent fatigue of individual fibers during submaximal exercise may reduce the muscular oxidative power...
February 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38388302/the-muscle-regeneration-marker-foxp3-is-associated-with-muscle-injury-in-duchenne-muscular-dystrophy
#36
JOURNAL ARTICLE
Sthephanie Yannin Hernández-de la Cruz, Thania Ordaz-Robles, Marco Antonio Villaldama-Soriano, Cristian Emmanuel Luna-Guzmán, Tomas Almeida-Becerril, Judith Villa-Morales, Alan Cárdenas-Conejo, Eugenia Dolores Ruíz-Cruz, Jorge Maldonado-Hernandez, Mariela Bernabe-Garcia, Lourdes Barbosa-Cortés, Maricela Rodríguez-Cruz
BACKGROUND: In Duchenne muscular dystrophy (DMD), the immune system cells (ISC) synthesize molecules to regulate inflammation, a process needed to regenerate muscle. The relationship between those molecules and the muscle injury is unknown. Monocytes belonging to ISC are regulated by omega-3 fatty acids (ω-3 LCPUFAs) in DMD, but whether those fatty acids influence other ISC like T-cells is unknown. OBJECTIVE: We analyzed the expression of the muscle regeneration markers (FOXP3 and AREG) in circulating leukocytes of DMD patients with different lower limb muscle functions and whether ω-3 LCPUFAs regulate the expression of those markers, and the populations of circulating T-cells, their intracellular cytokines, and disease progression (CD69 and CD49d) markers...
February 21, 2024: Brain & Development
https://read.qxmd.com/read/38378693/skeletal-muscle-regeneration-after-extensive-cryoinjury-of-caudal-myomeres-in-adult-zebrafish
#37
JOURNAL ARTICLE
Hendrik Oudhoff, Vincent Hisler, Florian Baumgartner, Lana Rees, Dogan Grepper, Anna Jaźwińska
Skeletal muscles can regenerate after minor injuries, but severe structural damage often leads to fibrosis in mammals. Whether adult zebrafish possess the capacity to reproduce profoundly destroyed musculature remains unknown. Here, a new cryoinjury model revealed that several myomeres efficiently regenerated within one month after wounding the zebrafish caudal peduncle. Wound clearance involved accumulation of the selective autophagy receptor p62, an immune response and Collagen XII deposition. New muscle formation was associated with proliferation of Pax7 expressing muscle stem cells, which gave rise to MyoD1 positive myogenic precursors, followed by myofiber differentiation...
February 20, 2024: NPJ Regenerative Medicine
https://read.qxmd.com/read/38378283/-characteristics-and-changes-of-cardiac-injury-with-age-in-children-of-duchenne-muscular-dystrophy-a-prospective-cohort-study
#38
JOURNAL ARTICLE
M Hu, T Xu, K Xu, Y K Guo, L Yu, H Y Xu, X T Cai, H Fu
Objective: To explore the characteristics and changes of cardiac injury with age in Duchenne muscular dystrophy (DMD) and its clinical significance. Methods: A prospective cohort study was conducted. The 215 patients diagnosed with DMD in West China Second Hospital from January 2019 to November 2022 and aged from 6 to 18 years were enrolled. Their clinical data, myocardial injury markers, routine electrocardiogram, cardiac magnetic resonance (CMR) and echocardiography were collected. The patients were divided into five age groups: 6-<8, 8-<10, 10-<12, 12-<14 and 14-18 years of age, and matched with healthy boys respectively...
March 2, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38373768/discussion-on-five-zang-organs-all-can-lead-to-low-back-pain-not-only-the-kidney
#39
JOURNAL ARTICLE
Xiaoxuan Geng, Sheng Chen
Low back pain (LBP) is the common disease in the department of acupuncture and moxibustion in hospital and is treated basically in terms of kidney deficiency. Through clinical observation and in association with classic literature, the authors proposes that the five zang -organs all can lead to LBP relevant to internal injury. Based on the analysis of typical cases, the authors expounds the nature of pain caused by each zang -organ and clarified the keys of the differentiation. LBP related to the liver is manifested mainly as lumbar soreness and distending pain, accompanied by the limited forward and backward extension of the lumbar vertebra...
February 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/38372443/topographic-mapping-of-the-sensorimotor-qualities-of-empathic-reactivity-a-psychophysiological-study-in-people-with-spinal-cord-injuries
#40
JOURNAL ARTICLE
Michele Scandola, Maddalena Beccherle, Rossella Togni, Giulia Caffini, Federico Ferrari, Salvatore Maria Aglioti, Valentina Moro
The experience of empathy for pain is underpinned by sensorimotor and affective dimensions which, although interconnected, are at least in part behaviorally and neurally distinct. Spinal cord injuries (SCI) induce a massive, below-lesion level, sensorimotor body-brain disconnection. This condition may make it possible to test whether sensorimotor deprivation alters specific dimensions of empathic reactivity to observed pain. To explore this issue, we asked SCI people with paraplegia and healthy controls to observe videos of painful or neutral stimuli administered to a hand (intact) or a foot (deafferented)...
February 19, 2024: Psychophysiology
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