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Muscular injuries

Navaneetha Santhanam, Lee Kumanchik, Xiufang Guo, Frank Sommerhage, Yunqing Cai, Max Jackson, Candace Martin, George Saad, Christopher W McAleer, Ying Wang, Andrea Lavado, Christopher J Long, James J Hickman
There are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are needed to evaluate NMJs for diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy or other neurodegenerative diseases or injury states. There are certainly no model systems, animal or human, that allows for isolated treatment of motoneurons or muscle capable of generating dose response curves to evaluate pharmacological activity of these highly specialized functional units...
February 27, 2018: Biomaterials
Katherine B Santosa, Alexandra M Keane, Albina Jablonka-Shariff, Bianca Vannucci, Alison K Snyder-Warwick
The terminal Schwann cell (tSC), a type of nonmyelinating Schwann cell, is a significant yet relatively understudied component of the neuromuscular junction. In addition to reviewing the role tSCs play on formation, maintenance, and remodeling of the synapse, we review studies that implicate tSCs in neuromuscular diseases including spinal muscular atrophy, Miller-Fisher syndrome, and amyotrophic lateral sclerosis, among others. We also discuss the importance of these cells on degeneration and regeneration after nerve injury...
March 13, 2018: Journal of Neuroscience Research
Emanuele D'Artibale, Paul B Laursen, John B Cronin
Performance in motorcycle road racing is typically considered as the summation of interactions between rider, motorcycle, tires, and environment. Despite the substantial investments made towards the development of motorcycle technology and the business interests of manufacturers, published research focusing on the riders is relatively sparse, and a bike-centered mentality tends to dominate the sport. This manuscript reviews the known human performance aspects of motorcycle road racing and suggests directions for future research...
March 13, 2018: Sports Medicine
Patrick J Buchanan, John A I Grossman, Andrew E Price, Chandan Reddy, Mustafa Chopan, Harvey Chim
BACKGROUND: Most brachial plexus birth injuries (BPBI) are caused by traction on the brachial plexus during a difficult delivery. Fortunately, the possibility of complete recovery from such an incident is relatively high, with only 10% to 30% of patients having prolonged and persistent disability. These patients have muscle imbalances and co-contractions typically localized around the shoulder and elbow. These imbalances and co-contractures cause abnormal motor performances and bone/joint deformities...
March 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
G Simonte, G Isernia, B Fiorucci, E Paciaroni, E Cieri, A Rebonato, M Lenti
During implantation of an Ovation endograft for abdominal aortic aneurysm correction a patient experienced anaphylactic reaction following polymer leakage outside the device circuit. Procedure was completed after hemodynamic stabilization. Since postoperative day ll, patient complained for loss of legs strength. Medullar injury was excluded by electromyography test and the clinical signs attributed to muscular necrosis and peripheral nerve involvement following arterial embolization. Furthermore, immediately after surgery, a wide erythematous area appeared in the lumbar region...
March 5, 2018: Annals of Vascular Surgery
Hsien-Chun Chiu, Chen-Yuan Chiu, Rong-Sen Yang, Ding-Cheng Chan, Shing-Hwa Liu, Chih-Kang Chiang
BACKGROUND: A global consensus on the loss of skeletal muscle mass and function in humans refers as sarcopenia and cachexia including diabetes, obesity, renal failure, and osteoporosis. Despite a current improvement of sarcopenia or cachexia with exercise training and supportive therapies, alternative and specific managements are needed to discover for whom are unable or unwilling to embark on these treatments. Alendronate is a widely used drug for osteoporosis in the elderly and postmenopausal women...
March 6, 2018: Journal of Cachexia, Sarcopenia and Muscle
André Santana, Jean Carlos Debastiani, Regina Inês Kunz, Pamela Buratti, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro, Márcia Miranda Torrejais, Gladson Ricardo Flor Bertolini
Physical exercise may help maintain muscle properties and functional improvement after peripheral nerve lesion, which may be enhanced by using biocompatible substances, such as sericin. The aim of this study was analyse the effect of sericin associated with swimming exercise on the phenotype, innervation, and functionality of the plantar muscle of Wistar rats. Forty randomly divided adult rats were used in five groups of eight animals: control, injury, sericin, exercise, exercise and sericin. The application of sericin was done on the spot, 100 μL, shortly after nerve compression...
February 2018: Journal of Exercise Rehabilitation
Amit Abraham, Ayelet Dunsky, Madeleine E Hackney, Ruth Dickstein
Elevé is a fundamental dance movement practiced routinely by dance students and serving as an integral component of screening in dance. It consists of ankle plantar flexion (PF) movement and is considered to be a frequent cause of foot and ankle injuries among dancers, with adolescent female dance students being at greatest risk for such injuries. Therefore, gaining additional knowledge regarding elevé functional range of motion (ROM) and inter-leg weightbearing distribution (WBD) properties among adolescent dance students is warranted for pedagogic, screening, injury prevention, and rehabilitation purposes...
March 15, 2018: Journal of Dance Medicine & Science
Carlos Cobo-Vázquez, Gemma De Blas, Pablo García-Canas, María Del Carmen Gasco-García
Cardiopulmonary resuscitation requires the provider to adopt positions that could be dangerous for his or her spine, specifically affecting the muscles and ligaments in the lumbar zone and the scapular spinal muscles. Increased fatigue caused by muscular activity during the resuscitation could produce a loss of quality and efficacy, resulting in compromising resuscitation. The aim of this study was to evaluate the maximum time a rescuer can perform uninterrupted chest compressions correctly without muscle fatigue...
2018: Anesthesia Progress
Markus Bleckwenn, Klaus Weckbecker, Sebastian Voss
HISTORY AND CLINICAL FINDINGS:  We report a 79-year-old patient with post-polio syndrome (PPS). In the course of this disease, recurrent upper abdominal pain and a therapy-resistant nausea developed without vomiting. In addition, the patient was limited by the combination of muscular weakness, obesity, dietary-treated diabetes and a degenerative spinal cord injury significantly in its mobility and physical capacity. INVESTIGATIONS AND DIAGNOSIS:  Despite extensive diagnostics, no somatic cause could be found neither for the nausea nor for the upper abdominal pain...
March 2018: Deutsche Medizinische Wochenschrift
Miguel Pishnamaz, Ulrike Schemmann, Christian Herren, Klemens Horst, Philipp Lichte, Frank Hildebrand, Hans-Christoph Pape, Philipp Kobbe
PURPOSE: This review addressed the question of whether minimally invasive surgery after traumatic thoracolumbar spine fractures can reduce paraspinal muscle injury, limit changes in muscular structure and function, and lead to better functional outcome. Special emphasis was given to studies using imaging techniques or electromyography to evaluate the lumbar multifidus muscle structure and function. METHODS: The authors searched the literature in the PubMed/Medline, EMBASE, by cross-referencing and additional hand search...
March 1, 2018: Journal of Musculoskeletal & Neuronal Interactions
Clark R Dickerson, Talia Alenabi, Bernard J Martin, Don B Chaffin
This study aimed to compare the activity of four shoulder muscles in individuals with low back pain (LBP), spinal cord injuries (SCI) and a control group, during one-handed load transfer trials. Nine individuals with minimum one-year of LBP, eleven with thoracic/lumbar SCI and nine healthy controls participated in this study. The activations of anterior deltoid, upper trapezius, infraspinatus and pectoralis major were recorded by surface EMG during one-handed transferring of a cylinder from a home shelve to six spatially distributed target shelves...
March 8, 2018: Ergonomics
Md Suhail Alam, Bruce Cooper, Joseph D Farris, Kasturi Haldar
Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use to treat neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo), 2-hydroxypropyl-beta-cyclodextrin (HPBCD) and polyethylene glycol (PEG) 400 improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann-Pick Type C (NPC) disease...
March 1, 2018: Scientific Reports
Alexander Morzycki, Andrew Simpson, Jason Williams
CLINICIAN'S CAPSULE What is known about the topic? Though government statistics exist, there is an overall paucity of data evaluating dog bite injuries. What did this study ask? We aimed to describe the nature of dog bite injuries, their management, and their long-term complications. What did this study find? Of 475 dog bites, large muscular breeds were most frequently implicated. Eleven percent of bites occurred in the head and neck region, three patients were admitted to the hospital, and a 10% infection rate was identified...
March 1, 2018: CJEM
Mark De Ste Croix, Abigail Priestley, Rhodri Lloyd, Jon Oliver
PURPOSE: Fatigue negatively alters dynamic knee control, and the functional hamstring/quadriceps ratio (H/QFUNC ) plays an important role in stabilizing the joint. The aim of this study was to investigate the influence of soccer-specific exercise on H/QFUNC in under (U) 13-, U15-, and U17-year-old female soccer players. METHODS: A total of 36 female players performed concentric and eccentric actions of the hamstrings at 60°, 120°, and 180°/s before and after an age group-specific field-based soccer protocol...
February 27, 2018: Pediatric Exercise Science
Dan Zhao, Shanwei Tao, Dewei Zhang, Mengyang Qin, Yijun Bao, Anhua Wu
PURPOSE: Traumatic meningoencephalocele primarily occurs as a rare but complex complication of cranial base and orbital roof fractures. Traumatic intraorbital meningoencephalocele, which is rare and easily overlooked, can be life-threatening since cephalomeningitis occurs due to cerebrospinal fluid (CSF) leakage. It is obscure for the operative indications or standard surgical methods of traumatic meningoencephaloceles since the combined intricate craniofacial and basal fractures, brain injury, and CSF leak may exist...
February 27, 2018: Brain Injury: [BI]
Renan F H Nunes, Rodolfo A Dellagrana, Fábio Y Nakamura, Cosme F Buzzachera, Flavia A M Almeida, Lucinar J F Flores, Luiz G A Guglielmo, Sérgio G da Silva
Purpose/Background: Strength asymmetries are related to knee injuries in intermittent sports players. The purpose of this study was to examine whether elite futsal players demonstrate strength asymmetries during knee isokinetic testing applying the Croisier et al.21 criteria. Methods: Forty male elite (27.9 ± 6.5 years) Brazilian futsal players participated in the study. The testing protocol required players to perform concentric contractions of both quadriceps and hamstring muscles at angular velocities of 60 °·s-1 and 240 °·s-1 and eccentric contractions of hamstring at 30 °·s-1 and 120 °·s-1 ...
February 2018: International Journal of Sports Physical Therapy
Rasmus S Husted, Jesper Bencke, Per Hölmich, Lars L Andersen, Kristian Thorborg, Thomas Bandholm, Bjørn Gliese, Hanne B Lauridsen, Grethe Myklebust, Per Aagaard, Mette K Zebis
Background: Reduced lower extremity muscle strength as well as reduced lower extremity muscle pre-activity (defined as muscular activity just prior to initial ground contact) during high-risk movements are factors related to increased risk of non-contact ACL injury in adolescent female athletes. A strong relationship exists between muscle strength and muscle activity obtained during an isometric contraction, however, whether these two measures are related when muscle activity is obtained during a movement associated with a high risk of non-contact ACL injury is not known...
February 2018: International Journal of Sports Physical Therapy
Walter Hemelryck, Josselin Calistri, Virginie Papadopoulou, Sigrid Theunissen, Christian Dugardeyn, Costantino Balestra
Background: World Rugby Union laws are constantly evolving towards stringent injury-prevention, particularly for contested scrums, since front row players are most at risk of cervical spine injuries. Recently, some countries have also introduced tailored training programs and minimum performance requirements for playing in the front row. Nevertheless, these approaches lack an objective assessment of each cervical muscle that would provide protective support. Objective: Since front row players are the most at risk for cervical spine injuries due to the specific type of contact during scrums, the purpose of this study was to ascertain whether significant differences exist in neck muscle size and range of motion between front row players and players of other positions, across playing categories...
February 2018: International Journal of Sports Physical Therapy
Jonathan D Hughes, Katrina Denton, Rhodri S Lloyd, Jon L Oliver, Mark De Ste Croix
Post-match assessment of creatine kinase (CK) activity and delayed-onset muscle soreness (DOMS) are common markers of exercise-induced muscle damage and recovery status in soccer players. These responses have not been examined in youth female players. This study examined the effect of competitive match play on CK activity and DOMS in elite youth players. Thirty-four elite female players, divided into three chronological age groups (U13, n=11; U15, n=10; U17 n=12). Players completed baseline testing for CK and DOMS that was repeated immediately (for DOMS), 80, 128 and 168 h post-competitive match play for CK...
February 23, 2018: International Journal of Sports Medicine
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