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https://www.readbyqxmd.com/read/28078802/evaluation-of-pva-biodegradable-electric-conductive-membranes-for-nerve-regeneration-in-axonotmesis-injuries-the-rat-sciatic-nerve-animal-model
#1
J Ribeiro, A R Caseiro, T Pereira, Pas Armada-da-Silva, I Pires, J Prada, I Amorim, I Leal Reis, S Amado, J D Santos, S Bompasso, S Raimondo, Asp Varejão, S Geuna, A L Luís, A C Maurício
The therapeutic effect of three polyvinyl alcohol (PVA) membranes loaded with electrically conductive materials - carbon nanotubes (PVA-CNTs) and polypyrrole (PVA-PPy) - were tested in vivo for neuro-muscular regeneration after an axonotmesis injury in the rat sciatic nerve. The membranes electrical conductivity measured was 1.5±0.5x10(-6) S/m, 579±0.6x10(-6) S/m, and 1837.5±0.7 x10(-6) S/m, respectively. At week-12, a residual motor and nociceptive deficit were present in all treated groups, but at week-12, a better recovery to normal gait pattern of the PVA-CNTs and PVA-PPy treated groups was observed...
January 12, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28075349/transthyretin-a-transporter-protein-essential-for-proliferation-of-myoblast-in-the-myogenic-program
#2
Eun Ju Lee, Smritee Pokharel, Arif Tasleem Jan, Soyeon Huh, Richelle Galope, Jeong Ho Lim, Dong-Mok Lee, Sung Wook Choi, Sang-Soep Nahm, Yong-Woon Kim, So-Young Park, Inho Choi
Irregularities in the cellular uptake of thyroid hormones significantly affect muscle development and regeneration. Herein, we report indispensable role of transthyretin (TTR) in maintaining cellular thyroxine level. TTR was found to enhance recruitment of muscle satellite cells to the site of injury, thereby regulating muscle regeneration. Fluorescence-activated cell sorting (FACS) and immunofluorescence analysis of TTRwt (TTR wild type) and TTRkd (TTR knock-down) cells revealed that TTR controlled cell cycle progression by affecting the expression of Cyclin A2...
January 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28069562/effect-of-electroacupuncture-on-the-expression-of-agrin-and-acetylcholine-receptor-subtypes-in-rats-with-tibialis-anterior-muscular-atrophy-induced-by-sciatic-nerve-injection-injury
#3
Jianqi Yu, Meng Wang, Junying Liu, Xiaoming Zhang, Shengbo Yang
OBJECTIVE: To investigate the effects of electroacupuncture (EA) on mRNA and protein expression of agrin, acetylcholine receptor (AChR)-ε and AChR-γ in a rat model of tibialis anterior muscle atrophy induced by sciatic nerve injection injury, and to examine the underlying mechanism of action. METHODS: Fifty-four adult Sprague-Dawley rats were divided into four groups: healthy control group (CON, n=6); sciatic nerve injury group (SNI, n=24), comprising rats euthanased at 1, 2, 4 and 6 weeks, respectively, after penicillin injection-induced SNI (n=6 each); CON+EA group (n=12), comprising healthy rats euthanased at 4 and 6 weeks (after 2 and 4 weeks, respectively, of EA at GB30 and ST36); and SNI+EA group, comprising rats euthanased at 4 and 6 weeks (after 2 and 4 weeks, respectively, of EA)...
January 9, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28068163/description-and-rate-of-musculoskeletal-injuries-in-air-force-basic-military-trainees-2012-2014
#4
Nathaniel S Nye, Mary T Pawlak, Bryant J Webber, Juste N Tchandja, Michelle R Milner
CONTEXT:  Musculoskeletal injuries are common in military trainees and have significant medical and operational effects. OBJECTIVE:  To provide current musculoskeletal injury epidemiology data for US Air Force basic military trainees. DESIGN:  Descriptive epidemiologic study with cross-sectional features. SETTING:  US Air Force Basic Military Training, Joint Base San Antonio-Lackland, Texas. PATIENTS OR OTHER PARTICIPANTS:  All recruits who entered training between July 1, 2012, and June 30, 2014...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28065869/predictors-of-radial-nerve-palsy-recovery-in-humeral-shaft-fractures-a-retrospective-review-of-17-patients
#5
Nadine Nachef, VarenkaBariatinsky, Steeve Sulimovic, Christian Fontaine, Christophe Chantelot
BACKGROUND: Radial nerve injury is common in humeral shaft fractures and fails to recover spontaneously in 30% of cases. Few studies have evaluated predictors of recovery.The objectives of this study were to identify predictors of radial nerve palsy recovery and to assess the usefulness of surgical radial nerve exploration in patients with pre-operative radial nerve palsy. HYPOTHESIS: Factors predicting the outcome of radial nerve palsy can be identified. METHODS: Of 373 patients with humeral shaft fractures between 2005 and 2012, 43 had radial nerve palsy, including 23 who were lost to follow-up and 17 who were evaluated retrospectively at a mean of 26 months (range, 12-84 months) after internal fixation...
January 5, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28058671/possible-muscle-repair-in-the-human-cardiovascular-system
#6
REVIEW
Linda Sommese, Alberto Zullo, Concetta Schiano, Francesco P Mancini, Claudio Napoli
The regenerative potential of tissues and organs could promote survival, extended lifespan and healthy life in multicellular organisms. Niches of adult stemness are widely distributed and lead to the anatomical and functional regeneration of the damaged organ. Conversely, muscular regeneration in mammals, and humans in particular, is very limited and not a single piece of muscle can fully regrow after a severe injury. Therefore, muscle repair after myocardial infarction is still a chimera. Recently, it has been recognized that epigenetics could play a role in tissue regrowth since it guarantees the maintenance of cellular identity in differentiated cells and, therefore, the stability of organs and tissues...
January 5, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28056759/should-we-be-concerned-about-the-inflammatory-response-to-endovascular-procedures
#7
Djordje Radak, Nenad Djukic, Slobodan Tanaskovic, Milan Obradovic, Desanka Cenic-Milosevic, Esma R Isenovic
Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28051980/physical-performance-and-attrition-among-u-s-air-force-trainees-participating-in-the-basic-military-training-fueling-initiative
#8
Carrissa G Bartlett, Susan Stankorb
INTRODUCTION: Dietary intake of military initial entry trainees is often inadequate because of the structured food environment, lack of snacking, and limited time for meals. Inadequate intake during training increases risk for injury, poor performance, and attrition from training. A performance nutrition initiative was implemented at Joint Base San Antonio Lackland to mitigate this inadequacy in Air Force trainees and better reflect recommendations for active populations and mitigate nutritional inadequacy...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28043056/speed-resistance-and-unexpected-accelerations-modulate-feed-forward-and-feedback-control-during-a-novel-weight-bearing-task
#9
Shih-Chiao Tseng, Keith R Cole, Michael A Shaffer, Michael A Petrie, Chu-Ling Yen, Richard K Shields
We developed a method to investigate feed-forward and feedback movement control during a weight bearing visuomotor knee tracking task. We hypothesized that a systematic increase in speed and resistance would show a linear decrease in movement accuracy, while unexpected perturbations would induce a velocity-dependent decrease in movement accuracy. We determined the effects of manipulating the speed, resistance, and unexpected events on error during a functional weight bearing task. Our long term objective is to benchmark neuromuscular control performance across various groups based on age, injury, disease, rehabilitation status, and/or training...
December 15, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28043054/dynamic-plantar-pressure-distribution-strength-capacity-and-postural-control-after-lisfranc-fracture-dislocation
#10
Alexander T Mehlhorn, Markus Walther, Tayfun Yilmaz, Lennart Gunst, Anja Hirschmüller, Norbert P Südkamp, Hagen Schmal
Substantial progress has been made in the operative treatment of Lisfranc fractures, however, the prognosis remains poor. We hypothesized that Lisfranc injuries change the postural control and muscle strength of the lower limb. Both are suggested to correlate with the clinical outcome and quality of life. 17 consecutive patients suffering from a Lisfranc fracture dislocation were registered, underwent open reduction and internal fixation and were followed-up for 50.5±25.7months (Mean±SDM). Biomechanical analysis of muscle strength capacities, postural control and plantar pressure distribution was assessed >6 month postoperatively...
December 19, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28043031/liver-5-ht7-receptors-a-novel-regulator-target-of-fibrosis-and-inflammation-induced-chronic-liver-injury-in-vivo-and-in-vitro
#11
Beyzagul Polat, Zekai Halici, Elif Cadirci, Emre Karakus, Yasin Bayir, Abdulmecit Albayrak, Deniz Unal
BACKGROUND AND AIM: Hepatocellular cancer (HCC) is the sixth most common cancer and liver fibrosis is strongly associated with HCC. Treatment options are limited, and preventive strategies should be developed. An important step in the beginning of liver fibrosis is a strong inflammatory response. 5-HT7 is the last recognized member of the serotonin receptor family and is expressed in both central nerve system and peripheral system and have a lot of functions like learning, memory, smooth muscular relaxation, in the control of circadian rhythms and thermoregulation, pain and migraine, schizophrenia, anxiety, cognitive disturbances, and even inflammation...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28032564/wearing-lead-aprons-in-surgical-operating-rooms-ergonomic-injuries-evidenced-by-infrared-thermography
#12
Dominique Alexandre, Marc Prieto, Fabien Beaumont, Redha Taiar, Guillaume Polidori
BACKGROUND: The purpose of this study is to quantify the impact of the weight of radiation protection lead aprons on the discomfort and the fatigue of the medical staff within an operating room of interventional gastroenterology. To quantify this fatigue, we analyzed variations of the physiological parameters, including heart rate, blood pressure, and cutaneous temperature; we compared two situations: the first within the classic endoscopy department (without apron) and the second within the operating room with apron...
November 2, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28027662/redox-control-of-skeletal-muscle-regeneration
#13
Emmeran Le Moal, Vincent Pialoux, Gaëtan Juban, Carole Groussard, Hassan Zouhal, Bénédicte Chazaud, Rémi Mounier
Skeletal muscle shows high plasticity in response to external demand. Moreover, adult skeletal muscle is capable of complete regeneration after injury, due to the properties of Muscle Stem Cells (MuSCs), the satellite cells, which follow a tightly regulated myogenic program to generate both new myofibers and new MuSCs for further needs. Whereas reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been associated with skeletal muscle physiology, their implication in the cell and molecular processes at work during muscle regeneration is more recent...
December 27, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28027145/chance-fractures-in-the-pediatric-population-are-often-misdiagnosed
#14
Lindsay M Andras, Kira F Skaggs, Haleh Badkoobehi, Paul D Choi, David L Skaggs
BACKGROUND: Flexion injuries of the spine range from mild compression fractures to severe flexion-distraction injuries, that is, Chance fractures. Chance fractures are often unstable and Arkader and colleagues demonstrated improved outcomes when Chance fractures are treated operatively compared with those managed nonoperatively. METHODS: A retrospective review was conducted of all patients treated over a 5-year period (2008 to 2013) for a flexion injury, either a Chance or a compression fracture, of the thoracolumbar spine at our tertiary pediatric level I trauma center...
December 23, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28012810/the-role-of-gender-and-physical-performance-on-injuries-an-army-study
#15
Morgan K Anderson, Tyson Grier, Esther O Dada, Michelle Canham-Chervak, Bruce H Jones
INTRODUCTION: In basic combat training, women experience twice as many injuries as men; however, evidence at the operational Army level is limited. This study aims to investigate the association between gender and injury likelihood while controlling for certain confounding factors in the operational Army. METHODS: Data were analyzed in 2015 from a cross-sectional study utilizing data from a 2010-2011 survey of light infantry Army Soldiers. Gender, age, body fat, tobacco use, Army Physical Fitness Test (2-mile run, push-ups, and sit-ups), occupational physical demand, and injury data were obtained via paper survey...
December 21, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28012765/impotence-following-radical-prostatectomy-insight-into-etiology-and-prevention
#16
Patrick C Walsh, Pieter J Donker
This study was undertaken to identify the cause of impotence in men undergoing radical prostatectomy, with the hope that this information may provide insight into the possible prevention of this complication. The autonomic innervation of the corpora cavernosa in the male fetus and newborn was traced to determine the topographical relationship between the pelvic nerve plexus, and the prostate, urethra and urogenital diaphragm. We have demonstrated that the branches of the pelvic plexus that innervate the corpora cavernosa are situated between the rectum and urethra, and penetrate the urogenital diaphragm near or in the muscular wall of the urethra...
December 21, 2016: Journal of Urology
https://www.readbyqxmd.com/read/28009956/new-onset-hemolytic-anemia-after-percutaneous-paravalvular-leak-closure
#17
Luís Almeida-Morais, António Fiarresga, Duarte Cacela, Lídia de Sousa, Ana Galrinho, Rui Rodrigues, Lurdes Ferreira, Rui Ferreira
BACKGROUND: Despite being usually clinically silent, paravalvular leak can present with congestive heart failure (CHF) or haemolytic anemia. Here, the case is reported of a paravalvular leak presenting with CHF, complicated by new-onset severe hemolytic anemia after percutaneous closure with a large ventricular septal duct (VSD) occlude device. METHODS: A 57-year-old patient presented with infectious endocarditis of a native mitral valve with major mitral regurgitation and was submitted for mitral valvuloplasty...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28008363/muscular-activity-and-physical-interaction-forces-during-lower-limb-exoskeleton-use
#18
Matthew Wilcox, Ashish Rathore, Dafne Zuleima Morgado Ramirez, Rui C V Loureiro, Tom Carlson
Spinal cord injury (SCI) typically manifests with a loss of sensorimotor control of the lower limbs. In order to overcome some of the disadvantages of chronic wheelchair use by such patients, robotic exoskeletons are an emerging technology that has the potential to transform the lives of patients. However, there are a number of points of contact between the robot and the user, which lead to interaction forces. In a recent study, the authors have shown that peak interaction forces are particularly prominent at the anterior aspect of the right leg...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28001757/photobiomodulation-triple-treatment-in-peripheral-nerve-injury-nerve-and-muscle-response
#19
Mira M Mandelbaum-Livnat, Mara Almog, Moshe Nissan, Emmanuel Loeb, Yuval Shapira, Shimon Rochkind
BACKGROUND: Muscle preservation or decrease in muscle degeneration and progressive atrophy are major challenges in patients with severe peripheral nerve injury (PNI). Considerable interest exists in the potential therapeutic value of laser phototherapy (photobiomodulation) for restoring denervated muscle atrophy and for enhancing regeneration of severely injured peripheral nerves. As previously published, the laser phototherapy has a protective and immediate effect in PNI. Laser phototherapy in the early stages of muscle atrophy may preserve the denervated muscle by maintaining creatinine kinase (CK) activity and the amount of acetylcholine receptor (AChR)...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27999718/the-effects-of-instrument-assisted-soft-tissue-mobilization-on-lower-extremity-muscle-performance-a-randomized-controlled-trial
#20
Nicole MacDonald, Russell Baker, Scott W Cheatham
BACKGROUND: Instrument-Assisted Soft Tissue Mobilization (IASTM) is a non-invasive therapeutic technique used to theoretically aid in scar tissue breakdown and absorption, fascial mobilization, and improved tissue healing. Researchers have hypothesized that utilizing IASTM will improve muscular efficiency and performance; yet previous Investigations has been focused on treating injury. OBJECTIVE: The purpose of this investigation was to explore the effects of IASTM on muscle performance to assess if typical treatment application affected measures of muscular performance...
December 2016: International Journal of Sports Physical Therapy
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