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https://www.readbyqxmd.com/read/29149920/gastrointestinal-and-hepatic-disease-in-the-inflammatory-myopathies
#1
REVIEW
Chiranjeevi Gadiparthi, Amneet Hans, Kyle Potts, Mohammad K Ismail
Although muscle weakness is the pathognomonic feature of idiopathic inflammatory myopathies, systemic organ involvement is not uncommon. The gastrointestinal and hepatic manifestations are well known. Oropharyngeal dysphagia is the most common gastrointestinal symptom and can be severe. Gastric and small intestinal motility disorders, including chronic intestinal pseudo-obstruction, celiac disease, and inflammatory bowel disease have been described. Comprehensive cancer screening is warranted soon after the diagnosis of inflammatory myopathies due to high risk of occult malignancies...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29148135/cadence-tracking-and-disturbance-rejection-in-functional-electrical-stimulation-cycling-for-paraplegic-subjects-a-case-study
#2
Lucas O da Fonseca, Antônio P L Bó, Juliana A Guimarães, Miguel E Gutierrez, Emerson Fachin-Martins
Functional electrical stimulation cycling has been proposed as an assistive technology with numerous health and fitness benefits for people with spinal cord injury, such as improvement in cardiovascular function, increase in muscular mass, and reduction of bone mass loss. However, some limitations, for example, lack of optimal control strategies that would delay fatigue, may still prevent this technology from achieving its full potential. In this work, we performed experiments on a person with complete spinal cord injury using a stationary tadpole trike when both cadence tracking and disturbance rejection were evaluated...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29137319/effects-of-growth-hormone-on-cardiac-remodeling-and-soleus-muscle-in-rats-with-aortic-stenosis-induced-heart-failure
#3
Aline R R Lima, Luana U Pagan, Ricardo L Damatto, Marcelo D M Cezar, Camila Bonomo, Mariana J Gomes, Paula F Martinez, Daniele M Guizoni, Dijon H S Campos, Felipe C Damatto, Katashi Okoshi, Marina P Okoshi
Background: Skeletal muscle wasting is often observed in heart failure (HF). The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis is impaired in HF. In this study, we evaluated the effects of GH on soleus muscle and cardiac remodeling in rats with aortic stenosis (AS)-induced HF. Methods: AS was created by placing a stainless-steel clip on the ascending aorta. After clinically detecting HF, GH (2 mg/kg/day) was subcutaneously injected for 14 days (AS-GH group)...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135478/contralateral-involvement-of-congenital-muscular-torticollis-and-clavicular-fracture
#4
Shin-Young Yim, Kihong Chang, Ah-Reum Ahn, Eun Ji Park, Jongwoo Kim
Congenital muscular torticollis (CMT) is known to concur with some conditions such as developmental dysplasia of the hip or brachial plexus injury, which gives us some insights for pathogenesis of CMT. While clavicular fracture is the most common fracture in newborns, little is known about concurrence of CMT and clavicular fracture. Our clinical experience led us to realize that concurrence of CMT and clavicular fracture tended to occur on the contralateral side for each other rather than the ipsilateral side...
November 10, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29132139/study-of-hspb6-insights-into-the-properties-of-the-multifunctional-protective-agent
#5
Fazhao Li, Han Xiao, Fangfang Zhou, Zhiping Hu, Binbin Yang
HSPB6(Heat shock protein B6), is also referred to as P20/HSP20. Unlike other many other members of sHSP(small Heat shock protein) family, which tend to form high-molecular-mass oligomers, in solution, human HSPB6 only forms dimers. However, it still exhibits chaperon-like activity comparable with that of HSPB5. It is expressed ubiquitously, with high and constitutive expression in muscular tissues. sHSPs characteristically function as molecular chaperones and HSPB6 also has a molecular chaperone activity. HSPB6 is up-regulated in response to diverse cellular stress or damage and protect cells from otherwise lethal conditions...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29128741/reliability-of-the-knee-muscle-co-contraction-index-during-gait-in-young-adults-with-and-without-knee-injury-history
#6
Maurice Mohr, Kristin Lorenzen, Luz Palacios-Derflingher, Carolyn Emery, Benno M Nigg
Despite the frequent use of the electromyography-based muscle co-contraction index (CCI) to examine muscular control of the knee joint in young adults with and without knee injury history, the reliability of the CCI in this population is unknown. The purpose of this study was to quantify within-day and between-day reliability of the knee muscle CCI during gait in young adults with and without knee injury history. Twenty young adults (10 males, 10 females) with and without history of intra-articular knee injury performed repeated gait analyses on two different days...
November 6, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29124664/downhill-exercise-alters-immunoproteasome-content-in-mouse-skeletal-muscle
#7
Cory W Baumann, Dongmin Kwak, Deborah A Ferrington, LaDora V Thompson
Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome responds to stressful situations that do not promote large perturbations in skeletal muscle proteolysis. The purpose of this study was to determine how an acute bout of muscular stress influences immunoproteasome content. To accomplish this, wild-type (WT) and immunoproteasome knockout lmp7 (-/-) /mecl1 (-/-) (L7M1) mice were run downhill on a motorized treadmill...
November 9, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29121498/cardiac-involvement-in-myotonic-dystrophy-the-role-of-troponins-and-n-terminal-pro-b-type-natriuretic-peptide
#8
Rea Valaperta, Claudia De Siena, Rosanna Cardani, Fortunata Lombardia, Edina Cenko, Benedetta Rampoldi, Barbara Fossati, Elisa Brigonzi, Roberta Rigolini, Paola Gaia, Giovanni Meola, Elena Costa, Raffaele Bugiardini
BACKGROUND AND AIMS: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are dominant inherited muscular dystrophies with multiple systemic involvement, often producing cardiac injury. This study sought to determine the clinical significance of elevated high sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI), and N-terminal pro B-type natriuretic peptide (NT-pro-BNP) in this population. METHODS: Sixty DM patients (35 men and 25 women; mean age: 45.1 years, range: 12-73 years) underwent clinical cardiac investigations and measurements of serum hs-cTnT, hs-cTnI, creatine kinase (CK), and NT-proBNP...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29117428/change-in-knee-flexor-torque-after-fatiguing-exercise-identifies-previous-hamstring-injury-in-football-players
#9
Cameron Lord, Fadi Ma'ayah, Anthony J Blazevich
PURPOSE: Muscular fatigue and inter-limb strength asymmetry are factors known to influence hamstring injury risk, however limb-specific exacerbation of knee flexor (hamstrings) torque production after fatiguing exercise has previously been ignored. To investigate changes in muscular force production before and after sport-specific (repeated-sprint) and non-specific (knee extension-flexion) fatiguing exercise, and explore the sensitivity and specificity of isokinetic endurance (i.e. muscle-specific) and single-leg vertical jump (i...
November 8, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29114512/the-runsmart-training-program-effect-on-oxygen-consumption-and-lower-extremity-biomechanics-during-running
#10
Jennifer Bogulski, Steven Gonser, Doug Bush, Rachel Bugner, Lindsey Clark, Lisa Farrell, Kristen Swanson, Michael David Ross
As recreational running continues to gain popularity, more individuals are seeking ways to improve running performance. RunSmart is a running intervention program designed to enhance a runner's form. In addition to correcting flaws in a runner's form, RunSmart offers the opportunity for runners to continue a regular regimen while slowly integrating changes in form. The purpose of this case series was twofold: to determine if the RunSmart program coincides with improvements in oxygen consumption (VO2), a variable often associated with better running performance times, and to evaluate the RunSmart program in regard to enhancing gait biomechanics...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29100184/does-a-not-so-recent-ankle-sprain-influence-interjoint-coordination-during-walking
#11
Philippe Dedieu, Rima Chamoun, Guilhaume Lacaud, Thibault Moulinat, Maxime Queron, Pier-Giorgio Zanone
BACKGROUND: Ankle sprains are common joint injuries in daily and sports activities, whose underlying mechanisms have been amply studied. If joint structures are directly damaged, neuromuscular activity can be affected, particularly in the time domain. This study aims to establish whether previous ankle injury correlates with changes in the inter-joint synergy of the entire lower limb and in the muscle activity pattern during walking. METHODS: Three-dimensional walking-gait analysis was conducted on twenty-four adults...
October 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29097231/poor-anaerobic-power-capability-and-static-balance-predicted-prospective-musculoskeletal-injuries-among-soldiers-of-the-101st-airborne-air-assault-division
#12
Takashi Nagai, Mita Lovalekar, Meleesa F Wohleber, Katherine A Perlsweig, Michael D Wirt, Kim Beals
Musculoskeletal injuries have negatively impacted tactical readiness. The identification of prospective and modifiable risk factors of preventable musculoskeletal injuries can guide specific injury prevention strategies for Soldiers and health care providers. OBJECTIVES: To analyze physiological and neuromuscular characteristics as predictors of preventable musculoskeletal injuries. DESIGN: Prospective-cohort study. METHODS: A total of 491 Soldiers were enrolled and participated in the baseline laboratory testing, including body composition, aerobic capacity, anaerobic power/capacity, muscular strength, flexibility, static balance, and landing biomechanics...
October 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29084406/a-retrospective-study-of-cervical-spine-mri-findings-in-children-with-abusive-head-trauma
#13
Lance S Governale, Farah W Brink, Charles P Pluto, Victoria A Schunemann, Rachel Weber, Jerome Rusin, Beth A Fischer, Megan M Letson
BACKGROUND/AIMS: Increasing attention has been given to the possible association of cervical spine (c-spine) injuries with abusive head trauma (AHT). The aims of this study were to describe c-spine MRI findings in hospitalized AHT patients. METHODS: This is a retrospective study of children under the age of 5 years with AHT admitted to hospital in 2004-2013. Those with c-spine MRI were identified, and the images were reviewed. RESULTS: 250 AHT cases were identified, with 34 (14%) undergoing c-spine MRI...
October 31, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29082820/cutaneous-irritancy-of-an-ibuprofen-medicated-plaster-in-healthy-volunteers
#14
Manisha Maganji, Mark P Connolly, Aomesh Bhatt
OBJECTIVE: Ibuprofen is a commonly used non-steroidal anti-inflammatory drug administered to treat injuries, joint pain, and recurrent muscular skeletal pain. The aim of this study was to determine the cutaneous irritancy of a medicated ibuprofen plaster compared with a placebo plaster in healthy volunteers. METHODS: Healthy volunteers (N=31) were treated at the same time with one ibuprofen and one placebo plaster. The ibuprofen and placebo plaster were applied in a randomized fashion to sites on the left or right side of subjects' lower backs...
October 28, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29081870/fun-during-knee-rehabilitation-feasibility-and-acceptability-testing-of-a-new-android-based-training-device
#15
Thomas Sanjay Weber-Spickschen, Christian Colcuc, Alexander Hanke, Jan-Dierk Clausen, Paul Abraham James, Hauke Horstmann
PURPOSE: The initial goals of rehabilitation after knee injuries and operations are to achieve full knee extension and to activate quadriceps muscle. In addition to regular physiotherapy, an android-based knee training device is designed to help patients achieve these goals and improve compliance in the early rehabilitation period. This knee training device combines fun in a computer game with muscular training or rehabilitation. Our aim was to test the feasibility and acceptability of this new device...
2017: Open Medical Informatics Journal
https://www.readbyqxmd.com/read/29078131/neuromuscular-electrophysiological-disorders-and-muscle-atrophy-in-mechanically-ventilated-traumatic-brain-injury-patients-new-insights-from-a-prospective-observational-study
#16
Paulo Eugênio Silva, Vinicius Maldaner, Luciana Vieira, Karina Livino de Carvalho, Hedian Gomes, Priscilla Melo, Nicolas Babault, Gerson Cipriano, Joao Luiz Quagliotti Durigan
PURPOSE: It is unclear whether the muscular changes in mechanically-ventilated traumatic brain injury patients (TBI) are only associated with disuse or additionally to neuromuscular electrophysiological disorders (NED). The correlation between muscle atrophy and NED may affect functional outcomes and rehabilitation programs significantly. MATERIAL AND METHODS: An observational study was performed to investigate the presence of NED and muscle atrophy in TBI patients undergoing mechanical ventilation...
October 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29076959/effects-of-pre-competitive-preparation-period-on-the-isokinetic-muscular-characteristics-in-world-class-handball-players
#17
Olivier Maurelli, Pierre Louis Bernard, Romain Dubois, Said Ahmaidi, Jacques Prioux
The aim of this study was to describe the effects of eight weeks of pre-competitive period preparation (Pc2P) on the isokinetic muscular characteristics in world-class handball players. Nineteen male professional players (age: 26.6 ± 5.4 years) participated in the study. Two bilateral isokinetic tests of knee joint flexors (H; Hamstring) and extensors (Q; Quadriceps) were performed before and after Pc2P to determine the peak torque (PT), the mean power (MP) and the ratios (agonist/antagonist, dominant/non-dominant and combined)...
October 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29072545/comparison-of-seating-powered-characteristics-and-functions-and-costs-of-electrically-powered-wheelchairs-in-a-general-population-of-users
#18
Michael John Dolan, Megan Jennifer Bolton, Graham Iain Henderson
PURPOSE: To profile and compare the seating and powered characteristics and functions of electrically powered wheelchairs (EPWs) in a general user population including equipment costs. METHOD: Case notes of adult EPW users of a regional NHS service were reviewed retrospectively. Seating equipment complexity and type were categorized using the Edinburgh classification. Powered characteristics and functions, including control device type, were recorded. RESULTS: 482 cases were included; 53...
October 26, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29068540/the-molecular-cross-talk-of-the-dystrophin-glycoprotein-complex
#19
REVIEW
Marta Gawor, Tomasz J Prószyński
The proper function of skeletal muscles relies on their ability to process signals derived from motor neurons, transmit stimuli along the muscle fibers, contract, and regenerate efficiently after injury. The dystrophin-glycoprotein complex (DGC; also called the dystrophin-associated protein complex) plays a central role in all of these processes. It acts as a transmembrane platform that anchors the extracellular matrix (ECM) to the intracellular cytoskeleton and makes muscle fibers more resistant to injury...
October 25, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29067668/advanced-methods-to-study-the-cross-talk-between-fibro-adipogenic-progenitors-and-muscle-stem-cells
#20
Luca Tucciarone, Usue Etxaniz, Martina Sandoná, Silvia Consalvi, Pier Lorenzo Puri, Valentina Saccone
Functional interactions between muscle (satellite) stem cells-MuSCs-and other cellular components of their niche (the fibro-adipogenic progenitors-FAPs) coordinate regeneration of injured as well as diseased skeletal muscles. These interactions are largely mediated by secretory networks, whose integrity is critical to determine whether repair occurs by compensatory regeneration leading to formation of new contractile fibers, or by maladaptive formation of fibrotic scars and fat infiltration. Here we provide the description of methods for isolation of FAPs and MuSCs from muscles of wild type and dystrophic mice, and protocols of cocultures as well as MuSC's exposure to FAP- derived exosomes...
2018: Methods in Molecular Biology
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