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https://www.readbyqxmd.com/read/29786625/differences-in-glenohumeral-joint-rotation-and-peak-power-output-between-super-league-and-championship-rugby-league-players
#1
Matthew R Haines
Haines, MR. Differences in glenohumeral joint rotation and peak power output between Super League and Championship Rugby League players. J Strength Cond Res 32(6): 1685-1691, 2018-Rugby league is a high-intensity sport with large impact forces sustained during play, resulting in high prevalence of shoulder injury. Consequently, shoulder strength and player power are important considerations for injury prevention and performance. Additionally, professional teams regularly compete against semiprofessional teams, where differences in physical conditioning could be marked...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29783071/mef2a-regulates-calpain-3-expression-in-l6-myoblasts
#2
Ronghua Wu, Jun Wang, Jian Yao, Zhangji Dong, Yan Liu, Mei Liu
Calpain 3 (Capn3), a skeletal muscle-specific member of the calpain family, executes some non-proteolytic functions besides its role as a Ca2+ -regulated proteolytic enzyme. Previously, we found that changes in Capn3 expression were linearly correlated with the degree of muscular atrophy following reversible sciatic nerve injury and that knockdown of Capn3 gene expression promoted myoblast differentiation. While the regulation of capn3 gene expression is interesting, transcriptional regulation of Capn3 is still unclear...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29775379/decision-to-return-to-sport-participation-after-anterior-cruciate-ligament-reconstruction-part-ii-self-reported-and-functional-performance-outcomes
#3
Jennifer L Werner, Julie P Burland, Carl G Mattacola, Jenny Toonstra, Robert A English, Jennifer S Howard
CONTEXT:   Anterior cruciate ligament (ACL) reconstruction (ACLR) is the most commonly used method for helping athletes regain function and return to preinjury activity levels after ACL injury. Outcomes after ACLR have suggested that athletes return to a level of function that would support a return to sport participation; however, in a recent meta-analysis, pooled return rates were only 55%. It is unclear whether this discrepancy is a result of functional impairments. OBJECTIVE:   To compare patient-reported outcomes (PROs), dynamic balance, dynamic functional performance, strength, and muscular endurance in athletes who have returned to sport (RTS) and athletes who have not returned to sport (NRTS) after ACLR...
May 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29774991/aggregate-mesenchymal-stem-cell-delivery-ameliorates-the-regenerative-niche-for-muscle-repair
#4
Marissa A Ruehle, Hazel Y Stevens, Aaron M Beedle, Robert E Guldberg, Jarrod A Call
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease due to the absence of the dystrophin protein from the muscle cell membrane which renders the muscle susceptible to continuous damage. In DMD patients, muscle weakness, together with cycles of degeneration/regeneration and replacement with non-contractile tissue, limit mobility and lifespan. Since the loss of dystrophin result in loss of polarity and a reduction in the number of self-renewing satellite cells, it is postulated that these patients could achieve an improved quality of life if delivered cells could restore satellite cell function...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29771357/a-promotive-effect-for-halofuginone-on-membrane-repair-and-synaptotagmin-7-levels-in-muscle-cells-of-dysferlin-null-mice
#5
Hila Barzilai-Tutsch, Melissa Dewulf, Christophe Lamaze, Gillian Butler Browne, Mark Pines, Orna Halevy
In the absence of dysferlin, skeletal muscle cells fail to reseal properly after injury, resulting in slow progress of the dysferlinopathy muscular dystrophy. Halofuginone, a leading agent in preventing fibrosis in muscular dystrophies, was tested for its effects on membrane resealing post-injury. A hypo-osmotic shock assay on myotubes derived from wild-type and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29767228/whiplash-injury-results-in-sustained-impairments-of-cervical-muscle-function-a-one-year-prospective-controlled-study
#6
Søren Krogh, Helge Kasch
OBJECTIVE: To investigate the temporal development of neck muscle function following whiplash injuries. DESIGN: A 1-year prospective, controlled observational study. SUBJECTS: A total of 141 individuals exposed to whiplash injury due to rear-end vehicle collisions and 40 age- and sex-matched controls with acute ankle distortion. METHODS: Neck muscle strength and endurance during cervical flexion and extension were measured at 1 week, 1 month, 3 months, 6 months and 1 year after injury...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29756600/the-development-of-neural-stimulators-a-review-of-preclinical-safety-and-efficacy-studies
#7
Robert K Shepherd, Joel Villalobos, Owen Burns, David Nayagam
OBJECTIVE: Given the rapid expansion of the field of neural stimulation and the rigorous regulatory approval requirements required before these devices can be applied clinically, it is important that there is clarity around conducting preclinical safety and efficacy studies required for the development of this technology. APPROACH: The present review examines basic design principles associated with the development of a safe neural stimulator and describes the suite of preclinical safety studies that need to be considered when taking a device to clinical trial...
May 14, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29754258/glycerol-induced-injury-as-a-new-model-of-muscle-regeneration
#8
REVIEW
Mohamed A A Mahdy
Skeletal muscle regenerates efficiently following injuries and diseases. However, muscle regeneration is compromised in several conditions by adipocyte infiltration and excessive collagen deposition. Adipocyte infiltration is a characteristic feature of sarcopenia, diabetes, cachexia, muscular dystrophies and advanced cases of Duchenne muscular dystrophy (DMD), while excessive collagen deposition is a hallmark of muscular dystrophies and severe muscle injuries, such as lacerations, contusions and strains. Muscle adipogenesis and fibrosis are major causes of muscle weakness that impairs muscle function...
May 12, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29743983/chemotherapeutic-drugs-and-mitochondrial-dysfunction-focus-on-doxorubicin-trastuzumab-and-sunitinib
#9
REVIEW
Stefania Gorini, Antonella De Angelis, Liberato Berrino, Natalia Malara, Giuseppe Rosano, Elisabetta Ferraro
Many cancer therapies produce toxic side effects whose molecular mechanisms await full elucidation. The most feared and studied side effect of chemotherapeutic drugs is cardiotoxicity. Also, skeletal muscle physiology impairment has been recorded after many chemotherapeutical treatments. However, only doxorubicin has been extensively studied for its side effects on skeletal muscle. Chemotherapeutic-induced adverse side effects are, in many cases, mediated by mitochondrial damage. In particular, trastuzumab and sunitinib toxicity is mainly associated with mitochondria impairment and is mostly reversible...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29712757/defective-flux-of-thrombospondin-4-through-the-secretory-pathway-impairs-cardiomyocyte-membrane-stability-and-causes-cardiomyopathy
#10
Matthew J Brody, Davy Vanhoutte, Tobias G Schips, Justin G Boyer, Chinmay V Bakshi, Michelle A Sargent, Allen J York, Jeffery D Molkentin
Thrombospondins are stress-inducible secreted glycoproteins with critical functions in tissue injury and healing. Thrombospondin-4 (Thbs4) is protective in cardiac and skeletal muscle where it activates an adaptive endoplasmic reticulum (ER) stress-response, induces expansion of the ER, and enhances sarcolemmal stability. However, it is unclear if Thbs4 has these protective functions from within the cell, from the extracellular matrix, or from the secretion process itself. Here we generated transgenic mice with cardiac-specific overexpression of a secretion-defective mutant of Thbs4 to evaluate its exclusive intracellular and secretion-dependent functions...
April 30, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29709414/contractile-property-measurement-of-the-torn-supraspinatus-muscle-using-real-time-tissue-elastography
#11
Takuma Yuri, Nariyuki Mura, Issei Yuki, Hiromi Fujii, Yoshiro Kiyoshige
HYPOTHESIS: In the restoration of shoulder abduction, decreased contractility of the torn rotator cuff muscle may be a cause of a poor result. The aim of this study was to investigate the relationship between the contractile property of the torn supraspinatus muscle measured by real-time tissue elastography and the Goutallier stage as modified by Fuchs et al. METHODS: The muscular hardness of the torn supraspinatus muscle was measured in 32 patients at rest and during isometric contraction with the shoulder abducted to 60° in the scapular plane...
April 27, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29708811/gender-differences-in-spinal-injuries-causes-and-location-of-injury
#12
Eliezer Sidon, Michael Stein, Ganesh Ramalingam, Shai Shemesh, Daniel Benharroch, Nissim Ohana
BACKGROUND: Spinal injury is common in trauma suffered by both men and women. A lesser degree of involvement of females with spinal trauma, or at least, the different nature of such injuries, has been suggested. It has been proposed that behavioral and structural characteristics may explain the differential type and severity of spinal injuries in women. We carried out this study to find women-specific divergences in spinal traumatic lesions, including suspected mechanisms for their generation...
April 30, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29696831/in-vitro-tissue-engineered-skeletal-muscle-models-for-studying-muscle-physiology-and-disease
#13
REVIEW
Alastair Khodabukus, Neel Prabhu, Jason Wang, Nenad Bursac
Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to small-scale injuries; however, this self-repair capacity becomes overwhelmed with aging, genetic myopathies, and large muscle loss. The failure of small animal models to accurately replicate human muscle disease, injury and to predict clinically-relevant drug responses has driven the development of high fidelity in vitro skeletal muscle models. Herein, the progress made and challenges ahead in engineering biomimetic human skeletal muscle tissues that can recapitulate muscle development, genetic diseases, regeneration, and drug response is discussed...
April 25, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29690525/quadrilateral-space-syndrome-diagnosis-and-clinical-management
#14
REVIEW
Patrick T Hangge, Ilana Breen, Hassan Albadawi, M Grace Knuttinen, Sailendra G Naidu, Rahmi Oklu
Quadrilateral space syndrome (QSS) is a rare disorder characterized by axillary nerve and posterior humeral circumflex artery (PHCA) compression within the quadrilateral space. Impingement is most frequently due to trauma, fibrous bands, or hypertrophy of one of the muscular borders. Diagnosis can be complicated by the presence of concurrent traumatic injuries, particularly in athletes. Since many other conditions can mimic QSS, it is often a diagnosis of exclusion. Conservative treatment is often first trialed, including physical exercise modification, physical therapy, and therapeutic massage...
April 21, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29687013/effects-of-game-pitch-count-and-body-mass-index-on-pitching-biomechanics-in-9-to-10-year-old-baseball-athletes
#15
Jim D Darke, Eshan M Dandekar, Arnel L Aguinaldo, Scott J Hazelwood, Stephen M Klisch
Background: Pitching while fatigued and body composition may increase the injury risk in youth and adult pitchers. However, the relationships between game pitch count, biomechanics, and body composition have not been reported for a study group restricted to 9- to 10-year-old athletes. Hypothesis: During a simulated game with 9- to 10-year-old athletes, (1) participants will experience biomechanical signs of fatigue, and (2) shoulder and elbow kinetics will correlate with body mass index (BMI)...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29687012/sex-based-differences-of-medial-collateral-ligament-and-anterior-cruciate-ligament-strains-with-cadaveric-impact-simulations
#16
Nathan D Schilaty, Nathaniel A Bates, Christopher V Nagelli, Aaron J Krych, Timothy E Hewett
Background: Female patients sustain noncontact knee ligament injuries at a greater rate compared with their male counterparts. The cause of these differences in the injury rate and the movements that load the ligaments until failure are still under dispute in the literature. Purpose/Hypotheses: This study was designed to determine differences in anterior cruciate ligament (ACL) and medial collateral ligament (MCL) strains between male and female cadaveric specimens during a simulated athletic task...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29670997/burn-survivors-pulmonary-and-muscular-impairment-exercise-tolerance-and-return-to-work-following-medical-vocational-rehabilitation-a-long-term-follow-up
#17
Viveca Björnhagen, Kristina Schüldt Ekholm, Flemming Larsen, Jan Ekholm
OBJECTIVE: To follow up the long-term outcome in return-to-work (RTW) rate in burn-injury patients, and to determine the degree of impairment in pulmonary and muscular function and exercise tolerance. DESIGN: A prospective, longitudinal follow-up study without a control group. PATIENTS: Twenty-five burn-injury patients referred for medical-vocational rehabilitation. METHODS: Return-to-work rate was followed after completed medical-vocational rehabilitation...
April 19, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29666879/-muscle-injuries-in-professional-football-treatment-and-rehabilitation
#18
REVIEW
H Riepenhof, R Del Vescovo, J-N Droste, S McAleer, A Pietsch
BACKGROUND: Muscle injuries are common in professional sports, especially in football. Recent epidemiological studies showed that muscle injuries account for more than 30% of professional football injuries (1.8-2.2/1000 h exposure); however, even though there are significant differences within a European comparison, a single professional football team diagnosed on average 12 muscle injuries per season, corresponding to more than 300 availability days lost. OBJECTIVE: The aim of this work is to present the diagnosis, general treatment and comprehensive management of muscle injuries in professional football...
April 17, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29662788/skeletal-muscle-regeneration-is-modulated-by-inflammation
#19
REVIEW
Wenjun Yang, Ping Hu
Skeletal muscle regeneration is a complex process orchestrated by multiple steps. Recent findings indicate that inflammatory responses could play central roles in bridging initial muscle injury responses and timely muscle injury reparation. The various types of immune cells and cytokines have crucial roles in muscle regeneration process. In this review, we briefly summarise the functions of acute inflammation in muscle regeneration. The translational potential of this article: Immune system is closely relevant to the muscle regeneration...
April 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29660062/minimally-invasive-exposure-of-the-maxillary-artery-at-the-anteromedial-infratemporal-fossa
#20
Roberto Rodriguez Rubio, Olivia Kola, Ali Tayebi Meybodi, Halima Tabani, Xuequan Feng, Jan-Karl Burkhardt, Sonia Yousef, Michael T Lawton, Arnau Benet
BACKGROUND: The maxillary artery (MA) has been described as a reliable donor for extracranial-intracranial high-flow bypass. Existing techniques to harvest MA require brain retraction and drilling of the middle fossa (with or without a zygomatic osteotomy), carrying the potential risks of venous bleeding, injury to the branches of the maxillary or mandibular nerves, muscular transection, or temporomandibular junction disorders. OBJECTIVE: To describe a novel technique to expose the MA without bony drilling and with minimal impact to surrounding structures...
April 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
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