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https://www.readbyqxmd.com/read/28092160/discovery-of-metabolite-biomarkers-for-acute-ischemic-stroke-progression
#1
Peifang Liu, Ruiting Li, Anton A Antonov, Lihua Wang, Wei Li, Yunfei Hua, Huimin Guo, Lijuan Wang, Peijia Liu, Lixia Chen, Yuan Tian, Fengguo Xu, Zunjian Zhang, Yulan Zhu, Yin Huang
Stroke remains a major public health problem worldwide; it causes severe disability and is associated with high mortality rates. However, early diagnosis of stroke is difficult, and no reliable biomarkers are currently established. In this study, mass spectrometry-based metabolomics was utilized to characterize the metabolic features of the serum of patients with acute ischemic stroke (AIS) to identify novel sensitive biomarkers for diagnosis and progression. First, global metabolic profiling was performed on a training set of 80 human serum samples (40 cases and 40 controls)...
January 16, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28091446/correlation-between-athlete-training-intensity-and-cardiac-performance
#2
T Xiao, Y Zhang
OBJECTIVE: An effective analysis of correlation between training intensity of athletes and cardiac performance is done to develop scientific and reasonable exercise program and to promote health of athletes. METHODS: During December 2013-December 2015, 3600 students from different sports schools were selected for the test. All the athletes were randomly grouped, that is half-hour running group, one-hour running group and 90 -minute running group, which are named A, B, C groups respectively...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28090141/do-maximal-aerobic-power-and-blood-lactate-concentration-affect-specific-judo-fitness-test-performance-in-female-judo-athletes
#3
H Garbouj, M A Selmi, R Haj Sassi, M Haj Yahmed, K Chamari, A Chaouachi
The Special Judo Fitness Test (SJFT) has become the test most widely used by coaches and physical trainers for assessment of competitors' judo-specific physical aptitude and training programme prescription. The aim of this study was to investigate the relationship between the SJFT performance indices and both maximal aerobic power and the level of blood lactate concentrations in female judo athletes. Seventeen female judokas (age: 21.9±1.6 years, body mass: 74.6±27.4 kg, height: 164.5±8.6 cm; BMI: 27.1±8...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28090138/agility-training-in-young-elite-soccer-players-promising-results-compared-to-change-of-direction-drills
#4
A Chaalali, M Rouissi, M Chtara, A Owen, N L Bragazzi, W Moalla, A Chaouachi, M Amri, K Chamari
The aim of this study was to compare the effect of two different training programmes - change of direction (COD) vs. agility (AG) - on straight sprint (SS), COD and AG test performances in young elite soccer players. Thirty-two soccer players (age: 14.5±0.9 years; height: 171.2±5.1 cm; body mass: 56.4±7.1 kg, body fat: 10.3±2.3%) participated in a short-term (6 weeks) training study. Players were randomly assigned to two experimental groups - training with change of direction drills (COD-G, n=11) or using agility training (AG-G, n= 11) - and to a control group (CON-G, n=10)...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28089608/piloting-the-united-kingdom-prescribing-safety-assessment-with-pharmacist-prescribers-in-scotland
#5
Fiona Reid, Ailsa Power, Derek Stewart, Anne Watson, Leon Zlotos, Derna Campbell, Trudi McIntosh, Simon Maxwell
BACKGROUND: Prescribing is a complex task requiring considerable knowledge and skills. The Prescribing Safety Assessment (PSA) was developed by the British Pharmacological Society and the United Kingdom (UK) Medical Schools Council. Between February and June 2014, over 7000 final year medical students undertook the PSA, with an overall pass rate of 94%. Independent prescribing for suitably trained pharmacists was introduced in the UK in 2006. To date there has been little focus on any objective measures of prescribing safety...
January 6, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28087244/practice-makes-perfect-correlations-between-prior-experience-in-high-level-athletics-and-robotic-surgical-performance-do-not-persist-after-task-repetition
#6
Kevin Shee, Fady M Ghali, Elias S Hyams
OBJECTIVE: Robotic surgical skill development is central to training in urology as well as in other surgical disciplines. Here, we describe a pilot study assessing the relationships between robotic surgery simulator performance and 3 categories of activities, namely, videogames, musical instruments, and athletics. DESIGN: A questionnaire was administered to preclinical medical students for general demographic information and prior experiences in surgery, videogames, musical instruments, and athletics...
January 10, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28079706/ibuprofen-before-exercise-does-not-prevent-cortical-bone-adaptations-to-training
#7
Vanessa D Sherk, R Dana Carpenter, Erin D Giles, Janine A Higgins, Robera M Oljira, Ginger C Johnson, Samuel Mills, Paul S MacLean
: Using a nonsteroidal anti-inflammatory drug (NSAID) before a single bout of mechanical loading can reduce bone formation response. It is unknown whether this translates to an attenuation of bone strength and structural adaptations to exercise training. PURPOSE: To determine whether NSAID use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise. METHODS: Adult female Wistar rats (n=43) were randomized to Ibuprofen (IBU) or Vehicle (VEH) and Exercise (EX) or Sedentary (SED) groups in a 2x2 (drug, activity) ANCOVA design with body weight as the covariate, and data are reported as mean±SE...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28078098/transfer-of-nursing-home-residents-to-emergency-departments-organizational-differences-between-nursing-homes-with-high-vs-low-transfer-rates
#8
Marie Kirsebom, Mariann Hedström, Ulrika Pöder, Barbro Wadensten
AIM: To explore possible factors in the organization of nursing homes that could be related to differences in the rate of transfer of residents from nursing homes to emergency department. DESIGN: Explorative. METHOD: In a single municipality, qualitative and quantitative data were collected from documents and through semi-structured interviews with 11 RNs from five nursing homes identified as having the highest vs. six identified as having the lowest transfer rates to emergency department...
January 2017: Nursing Open
https://www.readbyqxmd.com/read/28077751/performance-of-health-workers-using-an-electronic-algorithm-for-the-management-of-childhood-illness-in-tanzania-a-pilot-implementation-study
#9
Clotilde Rambaud-Althaus, Amani Shao, Josephine Samaka, Ndeniria Swai, Seneca Perri, Judith Kahama-Maro, Marc Mitchell, Valérie D'Acremont, Blaise Genton
In low-resource settings, where qualified health workers (HWs) are scarce and childhood mortality high, rational antimicrobial prescription for childhood illnesses is a challenge. To assess whether smartphones running guidelines, as compared with paper support, improve consultation process and rational use of medicines for children, a pilot cluster-randomized controlled study was conducted in Tanzania. Nine primary health-care facilities (HFs) were randomized into three arms: 1) paper algorithm, 2) electronic algorithm on a smartphone, and 3) control...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28076851/pse-analysis-a-python-package-for-dna-rna-and-protein-peptide-sequence-analysis-based-on-pseudo-components-and-kernel-methods
#10
Bin Liu, Hao Wu, Deyuan Zhang, Xiaolong Wang, Kuo-Chen Chou
To expedite the pace in conducting genome/proteome analysis, we have developed a Python package called Pse-Analysis. The powerful package can automatically complete the following five procedures: (1) sample feature extraction, (2) optimal parameter selection, (3) model training, (4) cross validation, and (5) evaluating prediction quality. All the work a user needs to do is to input a benchmark dataset along with the query biological sequences concerned. Based on the benchmark dataset, Pse-Analysis will automatically construct an ideal predictor, followed by yielding the predicted results for the submitted query samples...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28075147/evaluating-the-efficacy-of-the-feeding-exercise-randomized-trial-in-overweight-and-obese-adolescents
#11
Anna Patsopoulou, Zoi Tsimtsiou, Antonios Katsioulis, Eleni Malissiova, George Rachiotis, Christos Hadjichristodoulou
BACKGROUND: The Feeding Exercise Trial in Adolescents (FETA) aimed to evaluate whether a community-based, parents-involving, combined physical activity and nutritional education program was effective in improving adiposity profiles in overweight and obese adolescents. METHODS: A total of 181 overweight and obese adolescents aged 13-15 years old were randomized in the three study groups ("Diet & Activity," "Activity," and Control). The Activity intervention included a 45-minute, 3-day per week supervised training program, while the Diet & Activity intervention included a supplementary 15 minutes of group-based sessions attended by the parents...
January 11, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28069047/task-shifting-or-shifting-care-practices-the-impact-of-task-shifting-on-patients-experiences-and-health-care-arrangements-in-swaziland
#12
Thandeka Dlamini-Simelane, Eileen Moyer
BACKGROUND: In the quest to achieve early HIV treatment goals, national HIV treatment programmes dependent on international funding have been dramatically redesigned over the last 5 years. Bottlenecks in treatment provision are conceived of as health system problems to be addressed via structural and logistical fixes (routine HIV testing, point-of-care equipment, nurse-led antiretroviral treatment initiation, and patient tracking). Patient perspectives are rarely taken into account when such fixes are being considered...
January 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28068160/prediction-of-injuries-and-injury-types-in-army-basic-training-infantry-armor-and-cavalry-trainees-using-a-common-fitness-screen
#13
JoEllen M Sefton, K R Lohse, J S McAdam
CONTEXT:  Musculoskeletal injuries (MSIs) are among the most important challenges facing our military. They influence career success and directly affect military readiness. Several methods of screening initial entry training (IET) soldiers are being tested in an effort to predict which soldiers will sustain an MSI and to develop injury-prevention programs. The Army 1-1-1 Fitness Assessment was examined to determine if it could be used as a screening and MSI prediction mechanism in male IET soldiers...
November 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/28066524/bioenergetic-differences-during-walking-and-running-in-transfemoral-amputee-runners-using-articulating-and-non-articulating-knee-prostheses
#14
M Jason Highsmith, Jason T Kahle, Rebecca M Miro, Larry J Mengelkoch
Transfemoral amputation (TFA) patients require considerably more energy to walk and run than non-amputees. The purpose of this study was to examine potential bioenergetic differences (oxygen uptake (VO2), heart rate (HR), and ratings of perceived exertion (RPE)) for TFA patients utilizing a conventional running prosthesis with an articulating knee mechanism versus a running prosthesis with a non-articulating knee joint. Four trained TFA runners (n = 4) were accommodated to and tested with both conditions. VO2 and HR were significantly lower (p ≤ 0...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28064225/influence-of-mechanical-force-on-bone-matrix-proteins-in-ovariectomised-mice-and-osteoblast-like-mc3t3-e1-cells
#15
Meng Zhang, Shintaro Ishikawa, Tomoko Inagawa, Hideshi Ikemoto, Shiyu Guo, Masataka Sunagawa, Tadashi Hisamitsu
AIM: To investigate the effect of mechanical stress on periostin and semaphorin-3A expression in a murine model of postmenopausal osteoporosis and in osteoblast-like MC3T3-E1 cells. MATERIALS AND METHODS: Female mice were divided into three groups and treated with a sham operation, ovariectomy (OVX) or OVX plus treadmill training (OVX+Run). After 10 weeks, tibias were used for histological analysis. MC3T3-E1 cells were burdened by mechanical stress using a centrifuge or were treated with periostin, and the production of biologically-active semaphorin-3A was examined in vitro...
2, 2017: In Vivo
https://www.readbyqxmd.com/read/28060529/is-domain-highlighting-actually-helpful-in-identifying-phishing-web-pages
#16
Aiping Xiong, Robert W Proctor, Weining Yang, Ninghui Li
OBJECTIVE: To evaluate the effectiveness of domain highlighting in helping users identify whether Web pages are legitimate or spurious. BACKGROUND: As a component of the URL, a domain name can be overlooked. Consequently, browsers highlight the domain name to help users identify which Web site they are visiting. Nevertheless, few studies have assessed the effectiveness of domain highlighting, and the only formal study confounded highlighting with instructions to look at the address bar...
December 1, 2016: Human Factors
https://www.readbyqxmd.com/read/28060280/a-protocol-of-manual-tests-to-measure-sensation-and-pain-in-humans
#17
Matthew Kostek, Anna Polaski, Benedict Kolber, Austin Ramsey, Alexander Kranjec, Kimberly Szucs
Numerous qualitative and quantitative techniques can be used to test sensory nerves and pain in both research and clinical settings. The current study demonstrates a quantitative sensory testing protocol using techniques to measure tactile sensation and pain threshold for pressure and heat using portable and easily accessed equipment. These techniques and equipment are ideal for new laboratories and clinics where cost is a concern or a limiting factor. We demonstrate measurement techniques for the following: cutaneous mechanical sensitivity on the arms and legs (von-Frey filaments), radiant and contact heat sensitivity (with both threshold and qualitative assessments using the Visual Analog Scale (VAS)), and mechanical pressure sensitivity (algometer, with both threshold and the VAS)...
December 19, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28051980/physical-performance-and-attrition-among-u-s-air-force-trainees-participating-in-the-basic-military-training-fueling-initiative
#18
Carrissa G Bartlett, Susan Stankorb
INTRODUCTION: Dietary intake of military initial entry trainees is often inadequate because of the structured food environment, lack of snacking, and limited time for meals. Inadequate intake during training increases risk for injury, poor performance, and attrition from training. A performance nutrition initiative was implemented at Joint Base San Antonio Lackland to mitigate this inadequacy in Air Force trainees and better reflect recommendations for active populations and mitigate nutritional inadequacy...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28051899/serious-games-for-health-the-potential-of-metadata
#19
Stefan Göbel, Ralph Maddison
OBJECTIVE: Numerous serious games and health games exist, either as commercial products (typically with a focus on entertaining a broad user group) or smaller games and game prototypes, often resulting from research projects (typically tailored to a smaller user group with a specific health characteristic). A major drawback of existing health games is that they are not very well described and attributed with (machine-readable, quantitative, and qualitative) metadata such as the characterizing goal of the game, the target user group, or expected health effects well proven in scientific studies...
January 4, 2017: Games for Health
https://www.readbyqxmd.com/read/28048414/th-ab-207a-05-a-fully-automated-pipeline-for-generating-ct-images-across-a-range-of-doses-and-reconstruction-methods
#20
S Young, P Lo, J Hoffman, M Wahi-Anwar, F Noo, M Brown, M McNitt-Gray
PURPOSE: To evaluate the robustness of CAD or Quantitative Imaging methods, they should be tested on a variety of cases and under a variety of image acquisition and reconstruction conditions that represent the heterogeneity encountered in clinical practice. The purpose of this work was to develop a fully-automated pipeline for generating CT images that represent a wide range of dose and reconstruction conditions. METHODS: The pipeline consists of three main modules: reduced-dose simulation, image reconstruction, and quantitative analysis...
June 2016: Medical Physics
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