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Cardiovascular assessment

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https://www.readbyqxmd.com/read/28728140/effects-of-inorganic-arsenic-methylated-arsenicals-and-arsenobetaine-on-atherosclerosis-in-the-mouse-model-and-the-role-of-as3mt-mediated-methylation
#1
Luis Fernando Negro Silva, Maryse Lemaire, Catherine A Lemarié, Dany Plourde, Alicia M Bolt, Christopher Chiavatti, D Scott Bohle, Vesna Slavkovich, Joseph H Graziano, Stéphanie Lehoux, Koren K Mann
BACKGROUND: Arsenic is metabolized through a series of oxidative methylation reactions by arsenic (3) methyltransferase (As3MT) to yield methylated intermediates. Although arsenic exposure is known to increase the risk of atherosclerosis, the contribution of arsenic methylation and As3MT remains undefined. OBJECTIVES: Our objective was to define whether methylated arsenic intermediates were proatherogenic and whether arsenic biotransformation by As3MT was required for arsenic-enhanced atherosclerosis...
July 5, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28728066/baseline-serum-phosphatidylcholine-plasmalogen-concentrations-are-inversely-associated-with-incident-myocardial-infarction-in-patients-with-mixed-peripheral-artery-disease-presentations
#2
Joseph V Moxon, Rhondda E Jones, Gerard Wong, Jacquelyn M Weir, Natalie A Mellett, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge
BACKGROUND AND AIMS: Despite current best care, patients with peripheral artery disease (PAD) remain at high risk of myocardial infarction, and biomarkers to more accurately assess cardiovascular risk are needed. This study assessed the relationship between the serum lipidome and incident myocardial infarction in a cohort of PAD patients. METHODS: 265 PAD patients were followed up for a median of 23 months, during which 18 people suffered a myocardial infarction...
June 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28728065/c-reactive-protein-in-atherosclerosis-a-risk-marker-but-not-a-causal-factor-a-13-year-population-based-longitudinal-study-the-troms%C3%A3-study
#3
Agnethe Eltoft, Kjell Arne Arntzen, John-Bjarne Hansen, Tom Wilsgaard, Ellisiv B Mathiesen, Stein Harald Johnsen
BACKGROUND AND AIMS: CRP predicts cardiovascular disease (CVD) in large epidemiologic studies. The aim of the present study was to elucidate the role of CRP in atherosclerosis formation and progression in a prospective population-based study. METHODS: 6503 middle-aged subjects from The Tromsø study had serum CRP, carotid ultrasound and complete covariate data collected at baseline in 1994. Of these, 4730 and 2917 attended follow-up surveys with repeated assessments in 2001 and 2007, respectively...
July 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28728064/ldl-subfractions-are-associated-with-incident-cardiovascular-disease-in-the-malm%C3%A3-prevention-project-study
#4
Dov Shiffman, Judy Z Louie, Michael P Caulfield, Peter M Nilsson, James J Devlin, Olle Melander
BACKGROUND AND AIMS: After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lipids. METHODS: Using a case-cohort design, participants were randomly drawn from the Malmö Prevention Project (MPP), a population-based prospective study of 18,240 participants, and supplemented with additional incident CVD events (5764 participants, 1784 CVD events)...
July 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28727751/oral-health-and-cardiovascular-care-perceptions-of-people-with-cardiovascular-disease
#5
Paula Sanchez, Bronwyn Everett, Yenna Salamonson, Shilpi Ajwani, Sameer Bhole, Joshua Bishop, Karen Lintern, Samantha Nolan, Rohan Rajaratnam, Julie Redfern, Maria Sheehan, Fiona Skarligos, Lissa Spencer, Ravi Srinivas, Ajesh George
MAIN OBJECTIVE: The aim of this study was to explore the perception of patients with cardiovascular disease towards oral health and the potential for cardiac care clinicians to promote oral health. METHOD: A needs assessment was undertaken with twelve patients with cardiovascular disease attending cardiac rehabilitation between 2015 and 2016, in three metropolitan hospitals in Sydney, Australia. These patients participated in face-to-face semi-structured interviews...
2017: PloS One
https://www.readbyqxmd.com/read/28727707/continuing-anti-thrombotic-medication-during-low-to-intermediate-risk-spinal-procedures-a-retrospective-evaluation
#6
Noud van Helmond, Wesley Day, Kenneth B Chapman
BACKGROUND: The current American Society of Regional Anesthesia (ASRA) guidelines recommend discontinuing anti-thrombotic therapy prior to any interventional spine procedures to decrease the incidence of bleeding complications. However, discontinuing anti-thrombotics may pose considerable danger in terms of cerebrovascular and cardiovascular events. Recent evidence suggests that some spinal interventions may still be performed safely with anti-thrombotics on board and some practitioners thus elect to continue certain anti-thrombotics for these procedures...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28726471/the-impact-of-medication-nonadherence-on-the-relationship-between-mortality-risk-and-depression-in-heart-failure
#7
Emily C Gathright, Mary A Dolansky, John Gunstad, Joseph D Redle, Richard A Josephson, Shirley M Moore, Joel W Hughes
OBJECTIVE: Heart failure affects more than 5 million U.S. adults, and approximately 20% of individuals with heart failure experience depressive symptoms. Depression is detrimental to prognosis in heart failure, conferring approximately a 2-fold increase in mortality risk. Medication nonadherence may help explain this relationship because depressed patients are less likely to adhere to the medication regimen. METHOD: Depression, electronically monitored medication adherence, and mortality were measured in a sample of 308 patients with heart failure participating in a study of self-management behavior...
July 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28726152/cardiovascular-outcome-trial-update-in-diabetes-new-evidence-remaining-questions
#8
REVIEW
Rebecca Herbst, Wilburn Bolton, Afreen Shariff, Jennifer B Green
PURPOSE OF REVIEW: Seven trials of new agents to treat type 2 diabetes (T2DM) have been performed to assess cardiovascular (CV) safety. A significant amount of information regarding the effects of drugs in three classes is available, with new data from multiple other trials expected shortly. This article provides a summary of recently completed trials. RECENT FINDINGS: The dipeptidyl peptidase-4 inhibitors studied thus far do not alter the risk of major adverse CV events (MACE)...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28725448/differential-prevalence-and-associations-of-overweight-and-obesity-by-gender-and-population-group-among-school-learners-in-south-africa-a-cross-sectional-study
#9
Sarah Negash, Charles Agyemang, Tandi E Matsha, Nasheeta Peer, Rajiv T Erasmus, Andre P Kengne
BACKGROUND: Factors influencing the increasing prevalence of overweight/obesity among children and adolescents in sub-Saharan Africa remain unclear. We assessed the prevalence and determinants of overweight and obesity and effects on cardio-metabolic profile in school learners in the Western Cape, South Africa. METHODS: Cross-sectional data were collected from 7 to 18-year-old South African school learners attending 14 schools, randomly selected from 107 government schools in the areas...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28725259/cardiovascular-disease-risk-and-prevention-amongst-syrian-refugees-mixed-methods-study-of-m%C3%A3-decins-sans-fronti%C3%A3-res-programme-in-jordan
#10
Dylan R J Collins, Kiran Jobanputra, Thomas Frost, Shoaib Muhammed, Alison Ward, Abed Alrazzaq Shafei, Taissir Fardous, Sadeq Gabashneh, Carl Heneghan
BACKGROUND: The growing burden of non-communicable diseases (NCDs) presented new challenges for medical humanitarian aid and little was known about primary health care approaches for these diseases in humanitarian response. We aimed to evaluate Médecins Sans Frontières (MSF's) use of total CVD risk based prevention strategies amongst Syrian refugees in northern Jordan to identify opportunities to improve total CVD risk based guidance for humanitarian settings. METHODS: We evaluated CVD risk assessment and management in two outpatient NCD clinics in the Irbid governorate of Jordan using a mixed methods design with qualitative and quantitative strands of equal priority, integrated during data collection and interpretation...
2017: Conflict and Health
https://www.readbyqxmd.com/read/28724946/diastolic-augmentation-index-improves-radial-augmentation-index-in-assessing-arterial-stiffness
#11
Yang Yao, Liling Hao, Lisheng Xu, Yahui Zhang, Lin Qi, Yingxian Sun, Benqiang Yang, Frans N van de Vosse, Yudong Yao
Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight α, to achieve better performance over AI r in assessing arterial stiffness. 120 subjects (43 ± 21 years old) were enrolled...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724878/relationship-between-knowledge-of-cardiovascular-disease-risk-factors-and-watching-educational-television-materials-ma%C3%A5-opolska-cardiovascular-preventive-intervention-study-m-capri
#12
Anna Waśniowska, Grzegorz Kopeć, Jakub Podolec, Magdalena Kozela, Agnieszka Sarnecka, Klaudia Knap, Krystyna Szafraniec, Andrzej Pająk, Piotr Podolec
INTRODUCTION    The current guidelines on cardiovascular disease (CVD) prevention in clinical practice emphasizes on education in media in population-based approaches. OBJECTIVES    To assess the relationship between knowledge of CVD risk factors and watching educational television materials in the adult population. PATIENTS AND METHODS    After 22 months of repeated broadcasting of educational television materials, which addressed problems related to CVD, a postal survey was conducted on a random sample of 5000 persons aged 18 years or older...
July 4, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28724846/metabolic-and-inflammatory-changes-with-orlistat-and-sibutramine-treatment-in-obese-malaysian-subjects
#13
Belqes Abdullah Mohammad Al-Tahami, Ab Aziz Al-Safi Ismail, Zulkefli Sanip, Zurkurnai Yusoff, Tg Muzaffar Tm Shihabudin, Taran Singh Pall Singh, Aida Hanum Ghulam Rasool
INTRODUCTION: Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker. METHODS: Seventy-six obese subjects were randomly placed into two groups. The first group received three daily 120 mg dosages of orlistat for nine months (n=39), and the second group received a once daily 10 or 15 mg dosage of sibutramine for nine months (n=37)...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28724799/galantamine-alleviates-inflammation-and-insulin-resistance-in-patients-with-metabolic-syndrome-in-a-randomized-trial
#14
Fernanda M Consolim-Colombo, Carine T Sangaleti, Fernando O Costa, Tercio L Morais, Heno F Lopes, Josiane M Motta, Maria C Irigoyen, Luiz A Bortoloto, Carlos Eduardo Rochitte, Yael Tobi Harris, Sanjaya K Satapathy, Peder S Olofsson, Meredith Akerman, Sangeeta S Chavan, Meggan MacKay, Douglas P Barnaby, Martin L Lesser, Jesse Roth, Kevin J Tracey, Valentin A Pavlov
BACKGROUND: Metabolic syndrome (MetS) is an obesity-driven condition of pandemic proportions that increases the risk of type 2 diabetes and cardiovascular disease. Pathophysiological mechanisms are poorly understood, though inflammation has been implicated in MetS pathogenesis. The aim of this study was to assess the effects of galantamine, a centrally acting acetylcholinesterase inhibitor with antiinflammatory properties, on markers of inflammation implicated in insulin resistance and cardiovascular risk, and other metabolic and cardiovascular indices in subjects with MetS...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28724655/sex-differences-in-the-use-of-oral-anticoagulants-for-atrial-fibrillation-a-report-from-the-national-cardiovascular-data-registry-ncdr-%C3%A2-pinnacle-registry
#15
Lauren E Thompson, Thomas M Maddox, Lanyu Lei, Gary K Grunwald, Steven M Bradley, Pamela N Peterson, Frederick A Masoudi, Alexander Turchin, Yang Song, Gheorghe Doros, Melinda B Davis, Stacie L Daugherty
BACKGROUND: Despite higher thromboembolism risk, women with atrial fibrillation have lower oral anticoagulation (OAC) use compared to men. The influence of the CHA2DS2-VASc score or the introduction of non-vitamin K OACs on this relationship is not known. METHODS AND RESULTS: Using the PINNACLE National Cardiovascular Data Registry from 2008 to 2014, we compared the association of sex with OAC use (warfarin or non-vitamin K OACs) overall and by CHA2DS2-VASc score and examined temporal trends in OAC use by sex...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28724650/dynamic-relation-of-changes-in-weight-and-indices-of-fat-distribution-with-cardiac-structure-and-function-the-dallas-heart-study
#16
Bryan Wilner, Sonia Garg, Colby R Ayers, Christopher D Maroules, Roderick McColl, Susan A Matulevicius, James A de Lemos, Mark H Drazner, Ronald Peshock, Ian J Neeland
BACKGROUND: Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS: Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28724586/cardiovascular-health-in-young-adulthood-and-structural-brain-mri-in-midlife-the-cardia-study
#17
Michael P Bancks, Norrina B Allen, Prachi Dubey, Lenore J Launer, Donald M Lloyd-Jones, Jared P Reis, Stephen Sidney, Yuichiro Yano, Pamela J Schreiner
OBJECTIVE: To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure. METHODS: We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0-14) at baseline (aged 18-30 years in 1985-1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28724570/childhood-thyroid-function-body-composition-and-cardiovascular-function
#18
Mirjana Barjaktarovic, Tim Korevaar, Romy Gaillard, Yolanda B de Rijke, Theo J Visser, Vincent Wv Jaddoe, Robin P Peeters
OBJECTIVE: The cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in this association. DESIGN: Population-based prospective cohort of children (N=4251, median age 6 years, 95% range 5.7-8.0 years). METHODS: Thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured to assess thyroid function...
July 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28724547/long-term-effects-of-a-renin-inhibitor-versus-a-thiazide-diuretic-on-arterial-stiffness-and-left-ventricular-diastolic-function-in-elderly-hypertensive-patients
#19
Yoshiyuki Okada, Shigeki Shibata, Naoki Fujimoto, Stuart Alexander Best, Benjamin D Levine, Qi Fu
Arterial stiffness and cardiac function are important predictors of cardiovascular events in patients with hypertension even with adequate blood pressure (BP) control. We evaluated whether a direct renin inhibitor, aliskiren, reduces arterial stiffness and modulates left ventricular function compared with a diuretic, hydrochlorothiazide, in elderly hypertensives. Twenty one hypertensives [67±14 (SD) yrs] were randomly assigned to receive 6-month aliskiren (n=11) or hydrochlorothiazide (n=10) based therapy...
July 19, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28724037/impact-of-biological-therapy-on-body-composition-of-patients-with-chron-s-disease
#20
Julianne Campos Dos Santos, Carla Malaguti, Fernando de Azevedo Lucca, Andrea Lemos Cabalzar, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri, Liliana Andrade Chebli, Julio Maria Fonseca Chebli
Introduction: Protein-energy malnutrition in Crohn's disease (CD) has been reported in 20 to 92% of patients, and is associated with increased morbidity and mortality and higher costs for the health system. Anti-TNF drugs are a landmark in the clinical management, promoting prolonged remission in patients with CD. It is believed that the remission of this disease leads to nutritional recovery. The effect of biological therapy on body composition and nutritional status is unclear. Method: Prospective study of body assessment by bioelectrical impedance method in patients with moderate to severe CD undergoing treatment with infliximab...
May 2017: Revista da Associação Médica Brasileira
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