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Membrane oxygenator disfunction

G F Yan, C M Zhang, X Y Hong, Y Wang, C F Liu, P F Zhang, L Xiang, G F Wen, Z H Yang, X Xu, S Y Qian, G P Lu
OBJECTIVE: To review the use of non-open chest extracorporeal membrane oxygenation (ECMO) in pediatric intensive care unit (PICU) in China. METHOD: The survey was conducted in 28 tertiary hospitals in China mainland from March to October 2015. All children <18 years of age have been supported with non-open chest ECMO in PICU were reviewed.Patient demographics, diagnosis, indication for ECMO, details of ECMO support, complications, and patient survival were analyzed...
September 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
John W Hoffman, Timothy B Gilbert, Robert S Poston, Erik P Silldorff
Reperfusion of ischemic myocardium is required for tissue survival; however, reperfusion elicits pathologic consequences. Myocardial reperfusion injury is a multifarious process that is mediated in part by oxygen free radicals, neutrophil-endothelium interactions, apoptosis, and intracellular calcium overload. The oxygen paradox describes the contradictory need to delivery oxygen to ischemic tissue and the resultant reduction of oxygen to form free radicals that are involved in macromolecule oxidation, membrane disfunction, apoptosis, and damaged calcium sequestering ability, which results in hypercontracture...
December 2004: Journal of Extra-corporeal Technology
Kazuo Suzuki
Neutrophil disfunction, caused by a decreased production of effective radical oxygen species by myeloperoxidase (MPO) and NADPH oxidase within the neutrophil, may result in susceptibility to opportunistic fungal infections. In vitro, MPO produces OCl, which kills bacteria and viruses. In the case of MPO deficiency, susceptibility to Candida albicans infection was observed. Furthermore, it was demonstrated that MPO knockout mice were primarily susceptible to C. albicans infection. With regards to NADPH oxidase deficiency, such a patient was found to have severe chronic granulomatous disease (CGD) due to Aspergillus infection...
2002: Nihon Ishinkin Gakkai Zasshi, Japanese Journal of Medical Mycology
A J Moreno, D J Santos, C M Palmeira
Depriving heart tissue of their blood supply leads to a decrease in high-energy compounds and many metabolic disturbances. Following short periods of ischemia, heart can recover their physiological functions after reperfusion, but prolonged ischemia injures heart irreversibly. Mitochondrial disfunction is one of the most critical events associated to injury irreversibility because regeneration of a high ATP level is indispensable for recovery of cellular functions. Reperfusion injury is also implicated in the irreversible damage of the ischemic heart...
October 1998: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
E Alvarez-Fortes, L M Ruiz-PĂ©rez, F Bouillaud, E Rial, L Rivas
Rat uncoupling protein 1 (UCP1) was successfully translated in transfected Leishmania major promastigotes. Immune electron microscopy revealed that the protein was exclusively in the mitochondria. UCP1 expression was about 350,000 copies per promastigote, accounting for 4.7% of the total mitochondrial protein. In intact parasites, expression of UCP1 induced a slight increase in respiratory rate and a modest decrease in mitochondrial membrane potential (delta psi(m)). In contrast, in digitonin-permeabilized parasites, a significantly lower value both in delta psi(m) (57 +/- 10 vs 153 +/- 12 mV) and respiratory control ratio (0...
June 1, 1998: Molecular and Biochemical Parasitology
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