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Oxygenator disfunction

G F Yan, C M Zhang, X Y Hong, Y Wang, C F Liu, P F Zhang, L Xiang, G F Wen, Z H Yang, X Xu, S Y Qian, G P Lu
OBJECTIVE: To review the use of non-open chest extracorporeal membrane oxygenation (ECMO) in pediatric intensive care unit (PICU) in China. METHOD: The survey was conducted in 28 tertiary hospitals in China mainland from March to October 2015. All children <18 years of age have been supported with non-open chest ECMO in PICU were reviewed.Patient demographics, diagnosis, indication for ECMO, details of ECMO support, complications, and patient survival were analyzed...
September 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Jifeng Guo, Dan He, Lei Wang, Jifeng Kang, Nan Li, Xinxiang Yan, Beisha Tang
OBJECTIVE: To investigate the effect of the L10P mutation on the cellular mitochondrial disfunction. METHODS: Spectrophotometer, flow cytometry and electron microscope was utilized to examine cell viability, reactive oxygen species (ROS), mitochondrial transmembrane potential, complex I activity and mitochondrial morphous of the HEK293 monoclone cell lines, in which wild-type and L10P mutant DJ-1 protein are stably expressed. RESULTS: Compared with the cell lines expressing empty vector, we found the ROS levels were elevated, the cell viability, mitochondrial transmembrane potential, complex I activity were reduced in the cells expressing L10P mutant DJ-1 protein (P<0...
December 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Subhasish Mondal, Jay Jyoti Roy, Tanmoy Bera
Leishmaniasis is a growing health problem in many parts of the world partly due to drug resistance of the parasite. This study reports on the fisibility of studying mitochondrial properties of two forms of wild-type L. donovani through the use of selective inhibitors. Amastigote forms of L. donovani exhibited a wide range of sensitivities to these inhibitors. Mitochondrial complex II inhibitor thenoyltrifluoroacetone and FoF1-ATP synthase inhibitors oligomycin and dicyclohexylcarbodiimide were refractory to growth inhibition of amastigote forms, whereas they strongly inhibited the growth of promastigote forms...
October 2014: Journal of Bioenergetics and Biomembranes
Eliana Maci, Francesca Comito, Anna Maria Frezza, Giuseppe Tonini, Aldo Pezzuto
BACKGROUND: Tobacco smoke causes lung disfunction and inflammation. METHODS: Twenty-two consecutive smokers with undetermined lung nodules were included. All underwent a baseline imaging, exhaled carbon monoxide level evaluation and spirometry, repeated at three months from smoking cessation therapy. RESULTS: A significant reduction in size of the lung nodules was reported (p = .037) as a trend in number reduction (p = .11). A significant increase in blood arterial oxygen pressure (p < ...
October 2014: Cancer Investigation
Csaba Máthé, Márta M-Hamvas, Gábor Vasas
Cyanobacteria produce metabolites with diverse bioactivities, structures and pharmacological properties. The effects of microcystins (MCYs), a family of peptide type protein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of protein synthesis blocker will be discussed in this review. We are focusing mainly on cyanotoxin-induced changes of chromatin organization and their possible cellular mechanisms. The particularities of plant cells explain the importance of such studies. Preprophase bands (PPBs) are premitotic cytoskeletal structures important in the determination of plant cell division plane...
October 2013: Marine Drugs
Oana Deleanu, Diana Pocora, Dan Mihaicuta, Oana Arghir, Paraschiva Postolache, Ruxandra Ulmeanu, Florin Mihaltan
SESSION TYPE: Sleep PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) are frequently encountered diseases, their coexistence (overlap syndrome = OS) is due to chance and the prevalence is 0.5-1%. The literature shows that OS is associated with more severe nocturnal desaturation.METHODS: We conducted a retrospective study, analysing two populations, each of 24 patients with smoking history, diagnosed with OSA (apnea-hipopnea index AHI >5/h),one associating COPD, matched by gender , smoking status, age and AHI, regarding anthropometric variables, Epworth scale (ESS), pack-year index (PY), daytime saturation (SaO2) and sleep study reports...
October 1, 2012: Chest
Vesna Martinović, Ilijana Grigorov, Desanka Bogojević, Anja Petrović, Sofija Jovanović, Mirka Ilić, Svetlana Ivanović Matić
AIMS: Diabetes-related oxidative stress conditions lead to progressive tissue damage and disfunctionality. Mechanisms underlying liver pathophysiology during diabetes are not fully understood. The aim of this study was to find relationship between diabetes-related DNA damage in the rat liver and activities of prosurvival signaling pathways. METHODS: Effect of diabetes was analyzed two (development stage) and eight weeks (stable diabetes) after single intraperitoneal injection of streptozotocin...
2012: Cellular Physiology and Biochemistry
Giuseppe M C Rosano, Massimo Fini, Giuseppe Caminiti, Giuseppe Barbaro
Myocardial ischemia occurs for a mismatch between blood flow and metabolic requirements, when the rate of oxygen and metabolic substrates delivery to the myocardium is insufficient to meet the myocardial energy requirements for a given myocardial workload. During ischemia, substantial changes occur in cardiac energy metabolism, as a consequence of the reduced oxygen availability. Some of these metabolic changes are beneficial and may help the heart adapt to the ischemic condition. However, most of the changes are maladaptive and contribute to the severity of the ischemic injury leading stunned or hibernating myocardium, cell death and ultimately to contractile disfunction...
2008: Current Pharmaceutical Design
Piotr Gałecki, Antoni Florkowski, Małgorzata Mrowicka, Tadeusz Pietras, Elzbieta Gałecka
Depressive disorder is still a rising and important problem in the modern world, it affects about 15% of the population. Present forms of treatment are effective in about 70% and require monthly therapy which sometimes causes side effects. Last decade studies paid attention to theories different to monoaminergic and to neurodegenerative changes mainly in the limbic system of hippocampus. In this article authors show a relationship between calcium ions, glutaminergic transduction and disfunction of hypothalamic-pituitary-adrenal (HPA) axis...
January 2008: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Piotr Gałecki, Antoni Florkowski, Małgorzata Mrowicka, Katarzyna Malinowska, Elzbieta Gałecka
Depressive disorder is still a rising and important problem in the modem world, it affects about 15% of the population. Present forms of treatment are effective in about 70% and require monthly therapy which sometimes causes side effects. Last decade studies paid attention to theories different to monoaminergic and to neurodegenerative changes mainly in the limbic system of hippocampus. In this article authors show a relationship between calcium ions, glutaminergic transduction and disfunction of hypothalamic-pituitary-adrenal (HPA) axis...
December 2007: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
David Gómez de Antonio, Roberto Marcos, Rosalía Laporta, Gema Mora, Cristina García-Gallo, Pablo Gámez, Mar Córdoba, Javier Moradiellos, Piedad Ussetti, María C Carreño, José R Núñez, Joaquín Calatayud, Francisco Del Río, Andrés Varela
BACKGROUND: The scarcity of grafts for lung transplant and the growing number of candidates expecting an organ has led to an increase of deaths in patients waiting for lung transplantation. Non-heart-beating donors (NHBD) represent a promising source of grafts for those who are involved in clinical lung transplantation. We present the results of our series of 17 out-of-hospital NHBD lung transplantations performed since 2002. METHODS: We have collected data from 17 donors and recipients involved in NHBD lung transplants since 2002, as well as data referring to the type of procedure and peri-operative events...
May 2007: Journal of Heart and Lung Transplantation
María Angeles Martín Alonso, Ana Santamaría, Esther Saracíbar, Eduardo Arranz, José A Garrote, Ana Almaraz, Agustín Caro-Patón
BACKGROUND AND OBJECTIVE: There is a role of immunologic proinflammatory mediators in pathogenesis of distant organ disfunction in acute pancreatitis (AP). The aim is to evaluate the relationship between those mediators and liver, kidney and lung disfunction in patients with AP. PATIENTS AND METHOD: On the day of admission in 34 patients with AP, biochemical parameters of liver function, creatinine and arterial partial pressure of oxygen (PO2) were determined, and cut points were established...
March 24, 2007: Medicina Clínica
Eduardo H B Delgado, Emilio L Streck, João L Quevedo, Felipe Dal-Pizzol
Malathion is a pesticide used on a large scale and with high potential risk for human exposure. However, it is reasonable to hypothesize that while the malathion is metabolizing reactive oxygen species (ROS) can be generated and subsequently there is onset of an oxidative stress in central nervous system (CNS) structures: hippocampus, cortex, striatum and cerebellum of intoxicated rats due to mitochondrial respiratory chain disfunctions. The present study was therefore undertaken to evaluate malathion-induced lipid peroxidation (LPO), superoxide production from sub-mitochondrial particles and the activity of complexes II and IV of the mitochondrial respiratory chain...
August 2006: Neurochemical Research
V Lorenzo-Zúñiga, M A Alvarez, R Planas, R Morillas, E Domènech, E Cabré, M A Gassull
BACKGROUND AND OBJECTIVES: Gas exchange alterations have been described in cirrhotic patients; but by the moment, a few prospective studies have focused in them. The aim of this study was to describe the frequency and severity of gasometric alterations in hospitalized cirrhotic patients, a their correlation with hepatocellular disfunction. PATIENTS AND METHODS: 50 consecutive cirrhotic patients (41 males) admitted for liver decompensation (ascites, liver encephalopathy, alcoholic hepatitis and upper gastrointestinal bleeding) without acute or chronic cardiopulmonary disfunction were included in the study...
May 2005: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
Nidia Basso, Nora Paglia, Inés Stella, Elena M V de Cavanagh, León Ferder, María del Rosario Lores Arnaiz, Felipe Inserra
Experimental studies indicate that chronic long-term inhibition of the renin-angiotensin system (RAS) can prevent most of the deleterious effects due to aging in the cardiovascular system and in the kidney of the normal mouse and rat. In this review, all the information available on this subject provided by several studies performed by our research group during the last years is been described. Treatment was initiated either after weaning or at 12 months of age that is about half the normal life span of the rat...
June 30, 2005: Regulatory Peptides
John W Hoffman, Timothy B Gilbert, Robert S Poston, Erik P Silldorff
Reperfusion of ischemic myocardium is required for tissue survival; however, reperfusion elicits pathologic consequences. Myocardial reperfusion injury is a multifarious process that is mediated in part by oxygen free radicals, neutrophil-endothelium interactions, apoptosis, and intracellular calcium overload. The oxygen paradox describes the contradictory need to delivery oxygen to ischemic tissue and the resultant reduction of oxygen to form free radicals that are involved in macromolecule oxidation, membrane disfunction, apoptosis, and damaged calcium sequestering ability, which results in hypercontracture...
December 2004: Journal of Extra-corporeal Technology
Fahir Baraković, Zumreta Kusljugić, Elnur Smajić, Marko Buksa, Mustafa Hadziomerović
Dysfunction of the left chamber of the heart happens when the function is not sufficient to supply all organs with needed quantity of blood, oxygen and nourishing materials. Consequence is an exhaustion of the heart compensatory and peripheral mechanisms. The research is based on the results of the analysis of residual changes that remained since acute myocardium infarct got over (scar, contracture changes, conductivity) and analysis of the remained functional part of the left chamber myocardium. Electrocardiogram, echocardiography and exercise test were used...
2004: Medicinski Arhiv
M P Fink
Pyruvic acid is a simple 3 carbon a-keto-monocarboxylic acid. Recognition that pyruvate is an effective scavenger of reactive oxygen species (ROS) prompted investigators to use it as therapeutic agent for various pathological conditions that are thought to be mediated by redox dependent phenomena, like myocardial, intestinal or hepatic ischemia/reperfusion-induced injury. Ethyl Pyruvate showed to be more effective and safer than equimolar doses of sodium pyruvate. Ethyl Pyruvate showed to have anti-inflammatory effects...
May 2004: Minerva Anestesiologica
Pablo Castro, Reinaldo Venegas, Patricia Fardella, Osvaldo Pérez, Roberto Jalil, Miguel A Gutiérrez
A 33 years old woman was admitted to the hospital after four days with cough, dyspnea, orthopnea and hemoptysis. Blood pressure was 170/90 mmHg, pulse was 112 and temperature was normal. She had cyanosis and a left ventricular gallop, without heart murmurs. A chest radiograph revealed pulmonary edema and echocardiogram showed a global left ventricular systolic disfunction. Oxygen and furosemide were started, but cardiopulmonary collapse ensued. The patient was supported with mechanical ventilation and treated with inotropic drugs...
September 2003: Revista Médica de Chile
Yasukazu Saitoh, Rika Ouchida, Atsushi Kayasuga, Nobuhiko Miwa
Although it is well known that Bcl-2 can prevent apoptosis, the Bcl-2's anti-apoptotic mechanism is not fully understood. Here, we investigate the mechanism of oxidant-induced cell death and to investigate the role of Bcl-2 in the tert-butyl hydroperoxide (t-BuOOH)-induced oxidant injury in Rat-1 fibroblasts and their bcl-2 transfected counterparts, b5 cells. Treatment with t-BuOOH causes mitochondrial disfunction and induced morphological features consistent with apoptosis more markedly in Rat-1 cells than in b5 cells...
May 15, 2003: Journal of Cellular Biochemistry
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