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https://www.readbyqxmd.com/read/29040965/distribution-of-cancer-mortality-rates-by-province-in-south-africa
#1
Felix Made, Kerry Wilson, Ruxana Jina, Nonhlanhla Tlotleng, Samantha Jack, Vusi Ntlebi, Tahira Kootbodien
INTRODUCTION: Cancer mortality rates are expected to increase in developing countries. Cancer mortality rates by province remain largely unreported in South Africa. This study described the 2014 age standardised cancer mortality rates by province in South Africa, to provide insight for strategic interventions and advocacy. METHODS: 2014 deaths data were retrieved from Statistics South Africa. Deaths from cancer were extracted using 10th International Classification of Diseases (ICD) codes for cancer (C00-C97)...
October 14, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29036877/a-hybrid-cnn-feature-model-for-pulmonary-nodule-malignancy-risk-differentiation
#2
Huafeng Wang, Tingting Zhao, Lihong Connie Li, Haixia Pan, Wanquan Liu, Haoqi Gao, Fangfang Han, Yuehai Wang, YiFang Qi, Zhengrong Liang
The malignancy risk differentiation of pulmonary nodule is one of the most challenge tasks of computer-aided diagnosis (CADx). Most recently reported CADx methods or schemes based on texture and shape estimation have shown relatively satisfactory on differentiating the risk level of malignancy among the nodules detected in lung cancer screening. However, the existing CADx schemes tend to detect and analyze characteristics of pulmonary nodules from a statistical perspective according to local features only. Enlightened by the currently prevailing learning ability of convolutional neural network (CNN), which simulates human neural network for target recognition and our previously research on texture features, we present a hybrid model that takes into consideration of both global and local features for pulmonary nodule differentiation using the largest public database founded by the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI)...
October 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29034672/-motivations-and-obstacles-to-occupational-disease-claims-in-lung-cancer-patients-an-exploratory-psychosocial-study
#3
Manon Britel, Olivia Pérol, Stéphanie Blois Da Conceiçao, Manon Ficty, Houria Brunet, Virginie Avrillon, Barbara Charbotel, Béatrice Fervers
PURPOSE: The proportion of lung cancers with an occupational origin has been estimated to be between 10 and 20%. They are largely under-reported, as 60% are not compensated as occupational disease. Although most patients are not familiar with the process of compensation, other factors could explain this under-reporting. The aim of this study was to identify psychosocial factors that could impact patients with occupational lung cancer to claim for compensation. METHODS: We conducted a case study involving semi-structured interviews with eight lung cancer patients enrolled in a cohort designed to systematically screen occupational exposures and propose claims for compensation to work-related cancer patients...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29034208/prophylactic-cranial-irradiation-following-surgical-resection-of-early-stage-small-cell-lung-cancer-a-review-of-the-literature
#4
REVIEW
Brooke C Bloom, Alexander Augustyn, Boris Sepesi, Sunil Patel, Shalin J Shah, Ritsuko U Komaki, Steven E Schild, Stephen G Chun
With increasing use of low-dose screening CT scans, the diagnosis of early-stage small-cell lung cancer (SCLC) without evidence of mediastinal nodal or distant metastasis is likely to become more common, but the role of adjuvant therapies such as prophylactic cranial irradiation (PCI) are not well understood in this population. We performed a review of the literature pertaining to the impact of PCI in patients who underwent surgical resection of early-stage SCLC. Four studies were identified that were pertinent including three single-institution retrospective analyses and a National Cancer Database analysis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29033394/diagnostic-biomarkers-for-lung-cancer-prevention
#5
Roberto Gasparri, Rosalia Romano, Giulia Sedda, Alessandro Borri, Francesco Petrella, Domenico Galetta, Monica Casiraghi, Lorenzo Spaggiari
Lung cancer is the leading cause of death for neoplasm. The lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offers early detection but are invasive and expensive. Up to date these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodeled and it has been defined as a disease that has its own genetic, biological and metabolic identity and on this new awareness we should base the new screening methods...
October 16, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29033361/binding-of-pld2-generated-phosphatidic-acid-to-kif5b-promotes-mt1-mmp-surface-trafficking-and-lung-metastasis-of-mouse-breast-cancer-cells
#6
Ziqing Wang, Feng Zhang, Jingquan He, Ping Wu, Li Wei Rachel Tay, Ming Cai, Weiqi Nian, Yuanyuan Weng, Li Qin, Jeffrey T Chang, Laura B McIntire, Gilbert Di Paolo, Jianming Xu, Junmin Peng, Guangwei Du
Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2 promotes local invasion through the regulation of the plasma membrane targeting of MT1-MMP and its associated invadopodia. A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein...
October 11, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29028534/discovery-of-benzo-g-quinazolin-benzenesulfonamide-derivatives-as-dual-egfr-her2-inhibitors
#7
Mansour S Alsaid, Abdullah A Al-Mishari, Aiten M Soliman, Fatma A Ragab, Mostafa M Ghorab
An array of some new N-(substituted)-2-((4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-yl)thio)acetamide 5-19 were synthesized from the starting compound 4-(2-mercapto-4-oxobenzo[g]quinazolin-3(4H)-yl)benzenesulfonamide 4, to be assessed for their cytotoxic activity against A549 lung cancer cell line and to determine their inhibitory effect on EGFR tyrosine kinase enzyme. Compounds 5-19 showed high activity towards A549 cell line with IC50 values of 0.12-8.70 μM. Compounds 6, 12 and 18 were the most potent in this series...
September 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29026529/coordinating-erk-signaling-via-the-molecular-scaffold-kinase-suppressor-of-ras
#8
REVIEW
Danielle Frodyma, Beth Neilsen, Diane Costanzo-Garvey, Kurt Fisher, Robert Lewis
Many cancers, including those of the colon, lung, and pancreas, depend upon the signaling pathways induced by mutated and constitutively active Ras. The molecular scaffolds Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) play potent roles in promoting Ras-mediated signaling through the Raf/MEK/ERK kinase cascade. Here we summarize the canonical role of KSR in cells, including its central role as a scaffold protein for the Raf/MEK/ERK kinase cascade, its regulation of various cellular pathways mediated through different binding partners, and the phenotypic consequences of KSR1 or KSR2 genetic inactivation...
2017: F1000Research
https://www.readbyqxmd.com/read/29025589/potential-circulating-mirna-signature-for-early-detection-of-nsclc
#9
Ayda Arab, Morteza Karimipoor, Shiva Irani, Arda Kiani, Sirous Zeinali, Elham Tafsiri, Kambiz Sheikhy
Circulating microRNAs (c-miRNAs) are promising biomarkers for screening, early detection and prognosis of cancer. The purpose of this investigation was to identify a panel of c-miRNAs in plasma that could contribute to early detection of non-small cell lung cancer (NSCLC). We profiled the expression of 44 unique plasma miRNAs in training set of 34 NSCLC patients and 20 matched healthy individuals by miRCURY LNA™ Universal RT microRNA PCR Panel and calculated dysregulation fold changes using the 2-ΔΔCt equation...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29025257/utility-of-the-national-lung-screening-trial-criteria-for-estimation-of-lung-cancer-in-the-korean-population
#10
Ye Jin Lee, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
Purpose: Screening for lung cancer in high-risk patients using the National Lung Screening Trial (NLST) criteria resulted in a decreased lung cancer-related mortality rate. However, whether these criteria are applicable to the Korean has not been investigated thus far. Therefore, we estimated the utility of the NLST criteria as a screening tool for lung cancer in the Korean population. Materials and Methods: The total number of newly diagnosed lung cancer cases in 2013 was obtained from the Korea National Statistical Office...
October 12, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29024939/ailanthone-inhibits-non-small-cell-lung-cancer-cell-growth-through-repressing-dna-replication-via-downregulating-rpa1
#11
Zhongya Ni, Chao Yao, Xiaowen Zhu, Chenyuan Gong, Zihang Xu, Lixin Wang, Suyun Li, Chunpu Zou, Shiguo Zhu
BACKGROUND: The identification of bioactive compounds from Chinese medicine plays a crucial role in the development of novel reagents against non-small lung cancer (NSCLC). METHODS: High throughput screening assay and analyses of cell growth, cell cycle, apoptosis, cDNA microarray, BrdU incorporation and gene expression were performed. RESULTS: Ailanthone (Aila) suppressed NSCLC cell growth and colony formation in vitro and inhibited NSCLC tumour growth in subcutaneously xenografted and orthotopic lung tumour models, leading to prolonged survival of tumour-bearing mice...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29019328/second-primary-tumors-associated-with-breast-cancer-kuwait-cancer-control-center-experience
#12
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Sadeq Abuzalouf
OBJECTIVES: To review the clinico-epidemiologic characteristics of patients who presented with two or more primary cancers, one of which was breast cancer (BC) and to develop a follow-up program for the high risk patients. PATIENTS AND METHODS: Patients who were diagnosed with BC and one or more non breast cancer (NBC) were retrospectively reviewed. Medical files were retrieved and epidemiological as well as clinical data were analyzed. RESULTS: Sixty-two patients were retrieved...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29017792/three-dimensional-printing-of-navigational-template-in-localization-of-pulmonary-nodule-a-pilot-study
#13
Lei Zhang, Mu Li, Zeyao Li, Xiermaimaiti Kedeer, Long Wang, Ziwen Fan, Chang Chen
BACKGROUND: Small pulmonary nodules are a common problem, especially with the wide implementation of lung cancer-screening program. This poses a great challenge to thoracic surgeons because of the difficulty of nodule localization. We recently built an efficient, customized navigational template using 3-dimensional (3D) printing technology to facilitate the procedure of lung nodule localization. This study aims to investigate its feasibility in clinical application. METHODS: Patients with peripheral lung nodules (<2 cm) were enrolled...
September 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28993508/personalized-sirna-nanoparticle-systemic-therapy-using-metastatic-lymph-node-specimens-obtained-with-ebus-tbna-in-lung-cancer
#14
Tatsuya Kato, Daiyoon Lee, Huang Huang, William Cruz-Munoz, Hideki Ujiie, Kosuke Fujino, Hironobu Wada, Priya Patel, Hsin-Pei Hu, Kentaro Hirohashi, Takahiro Nakajima, Masaaki Sato, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Juan Chen, Gang Zheng, Kazuhiro Yasufuku
Inhibiting specific gene expression with short interfering RNA (siRNA) provides a new therapeutic strategy to tackle many diseases at the molecular level. Recent strategies called high-density lipoprotein (HDL)-mimicking peptide-phospholipid nanoscaffold (HPPS) nanoparticles have been used to induce siRNAs-targeted delivery to scavenger receptor class B type I receptor (SCARB1) expressing cancer cells with high efficiency. Here, eight ideal therapeutic target genes were identified for advanced lung cancer throughout the screenings using endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA) and the establishment of a personalized siRNA-nanoparticle therapy...
October 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28991559/imaging-and-screening-for-colorectal-cancer-with-ct-colonography
#15
REVIEW
Perry J Pickhardt
Despite being readily preventable, colorectal cancer ranks second behind only lung cancer in overall mortality. However, this situation could be reversed if screening tests that effectively detect advanced adenomas and early cancers were broadly applied. Computed tomographic colonography (CTC) reflects an ideal balance of minimal invasiveness with high-level performance, assuming all facets of the examination are appropriately addressed. Unfortunately, this promising screening test remains grossly underused...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28991558/lung-cancer-screening-why-when-and-how
#16
REVIEW
Florian J Fintelmann, Ravi V Gottumukkala, Shaunagh McDermott, Matthew D Gilman, Inga T Lennes, Jo-Anne O Shepard
This article explains the rationale of lung cancer screening with low-dose computed tomography and provides a practical approach to all relevant aspects of a lung cancer screening program. Imaging protocols, patient eligibility criteria, facility readiness, and reimbursement criteria are addressed step by step. Diagnostic criteria and Lung-RADS (Lung Computed Tomography Screening Reporting and Data System) nodule management pathways are illustrated with examples. Pearls and pitfalls for interpretation of lung cancer screening low-dose chest computed tomography are discussed...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28991240/polypharmacology-based-ceritinib-repurposing-using-integrated-functional-proteomics
#17
Brent M Kuenzi, Lily L Remsing Rix, Paul A Stewart, Bin Fang, Fumi Kinose, Annamarie T Bryant, Theresa A Boyle, John M Koomen, Eric B Haura, Uwe Rix
Targeted drugs are effective when they directly inhibit strong disease drivers, but only a small fraction of diseases feature defined actionable drivers. Alternatively, network-based approaches can uncover new therapeutic opportunities. Applying an integrated phenotypic screening, chemical and phosphoproteomics strategy, here we describe the anaplastic lymphoma kinase (ALK) inhibitor ceritinib as having activity across several ALK-negative lung cancer cell lines and identify new targets and network-wide signaling effects...
October 9, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28989038/risk-of-second-lung-cancer-in-patients-with-previously-treated-lung-cancer-analysis-of-surveillance-epidemiology-and-end-results-seer-data
#18
Manish K Thakur, Julie J Ruterbusch, Ann G Schwartz, Shirish M Gadgeel, Jennifer L Beebe-Dimmer, Antoinette J Wozniak
BACKGROUND: The risk of developing a second primary lung cancer (SPLC) after the treatment of an initial primary lung cancer (IPLC) is around 1-2 % per patient per year. Present screening/surveillance guidelines do not adequately address this particular patient population. PATIENTS AND METHODS: We retrospectively reviewed patients in the Surveillance, Epidemiology, and End Results (SEER) data base from 1992 to 2007 to assess the frequency of occurrence of SPLC with regard to multiple patient demographics and calculated Standardized Incidence Ratios (SIRs)...
October 5, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28988941/the-economic-impact-of-a-nurse-practitioner-directed-lung-cancer-screening-incidental-pulmonary-nodule-and-tobacco-cessation-clinic
#19
Christopher R Gilbert, Rob Ely, Joelle T Fathi, Brian E Louie, Candice L Wilshire, Hannah Modin, Ralph W Aye, Alexander S Farivar, Eric Vallières, Jed A Gorden
OBJECTIVE: Lung cancer screening programs have become increasingly prevalent within the United States after the National Lung Screening Trial results. We aimed to review the financial impact after programmatic implementation of Advanced Registered Nurse Practitioner-led programs of Lung Cancer Screening and Tobacco Related Diseases, Incidental Pulmonary Nodule Clinic, and Tobacco Cessation Services. METHODS: We reviewed revenue from 2013 to 2016 by our nurse practitioner-led program...
September 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28986629/incidental-perifissural-nodules-on-routine-chest-computed-tomography-lung-cancer-or-not
#20
Onno M Mets, Kaman Chung, Ernst Th Scholten, Wouter B Veldhuis, M Prokop, Bram van Ginneken, Cornelia M Schaefer-Prokop, Pim A de Jong
OBJECTIVES: Perifissural nodules (PFNs) are a common finding on chest CT, and are thought to represent non-malignant lesions. However, data outside a lung cancer-screening setting are currently lacking. METHODS: In a nested case-control design, out of a total cohort of 16,850 patients ≥ 40 years of age who underwent routine chest CT (2004-2012), 186 eligible subjects with incident lung cancer and 511 controls without were investigated. All non-calcified nodules ≥ 4 mm were semi-automatically annotated...
October 6, 2017: European Radiology
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