keyword
https://read.qxmd.com/read/38546811/structure-based-multitargeted-docking-screening-pharmacokinetics-dft-and-dynamics-simulation-studies-reveal-mitoglitazone-as-a-potent-inhibitor-of-cellular-survival-and-stress-response-proteins-of-lung-cancer
#1
JOURNAL ARTICLE
Abdulkarim S Binshaya, Omar Saad Alkahtani, Fahad M Aldakheel, Ahmed Hjazi, Hassan H Almasoudi
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is responsible for more than 1.8 million deaths yearly and is expected to rise to 2.2 million by 2030. The most common type of lung cancer is non-small cell lung cancer (NSCLC), which accounts for about 80% and small cell lung cancer (SCLC), which is more aggressive than NSCLC and is often diagnosed later and accounts for 20% of cases...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546067/a-comparative-analysis-on-the-potential-anticancer-properties-of-tetrahydrocannabinol-cannabidiol-and-tetrahydrocannabivarin-compounds-through-in-silico-approach
#2
JOURNAL ARTICLE
Angelica A Gallardo, Mikaela Rose Gutierrez, Lyka Alexandrea J Gomez, Patricia Arielle O Delos Reyes, Sophia Allison A Dones, Maria Mikaela U Dumbrique, Heather Eena Lim, Maria Isabel H Liquido, Mary Margaret L Macawile, Ella Denese Anne B Maglaqui, Angelica Mae G Manalo, Mark Kevin P Devanadera, Alexis M Labrador
OBJECTIVE: The purpose of this study is to comparatively analyze the anticancer properties of Tetrahydrocannabinol (THC), Cannabidiol (CBD), and Tetrahydrocannabivarin (THCV) using In silico tools. METHODS: Using SwissADME and pkCSM, the physicochemical and pharmacokinetics properties of the cannabinoids were evaluated. Protox-II was utilized for the assessment of their cytotoxicity. The chemical-biological interactions of the cannabinoids were also predicted using the Way2Drug Predictive Server which comprises Acute Rat Toxicity, Adver-Pred, CLC-Pred, and Pass Target Prediction...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545483/association-of-lung-cancer-risk-with-the-presence-of-both-lung-nodules-and-emphysema-in-a-lung-cancer-screening-trial
#3
JOURNAL ARTICLE
Ya Liu, Zhuo Wei Feng, Xiao Min Liu, Hong Yuan Duan, Zhang Yan Lyu, Yu Bei Huang, Fang Fang Song, Feng Ju Song
BACKGROUND: The coexistence of emphysema and lung nodules could interact with each other and then lead to potential higher lung cancer risk. The study aimed to explore the association between emphysema combined with lung nodules and lung cancer risk. METHODS: A total of 21,949 participants from the National Lung Screening Trial (NLST) who underwent low-dose computed tomography (LDCT) examination were included. Participants were categorized into four groups (NENN group (non-emphysema and non-nodules), E group (emphysema without nodules), N group (nodules without emphysema), and E + N group (nodules with emphysema)) according to whether there were lung nodules and emphysema...
April 2024: World Journal of Oncology
https://read.qxmd.com/read/38545369/a-case-report-of-pulmonary-edema-secondary-to-large-volume-bowel-preparation-in-a-high-risk-patient-with-multiple-cardiopulmonary-co-morbidities
#4
Kush Fansiwala, Preeti Prakash, Christopher L Coe, Guy A Weiss
INTRODUCTION: Polyethylene glycol 3,350 and electrolytes is a commonly prescribed bowel regimen for colonoscopy preparation with an overall excellent safety profile, though prior reports have demonstrated risk of volume overload. CASE PRESENTATION: A 55-year-old man with significant cardiopulmonary co-morbidities was admitted for acute hypoxic respiratory failure and subsequent evaluation for lung transplant. As part of his pretransplant evaluation, colon cancer screening was advised...
2024: Case Reports in Gastroenterology
https://read.qxmd.com/read/38545147/activation-of-astrocytes-by-anxa2-derived-extracellular-vesicles-from-lung-cancer-cells-affects-aggressiveness-immunotherapy-response-and-microenvironment-of-lung-cancer
#5
JOURNAL ARTICLE
Mudan He, Guogang Xie, Fang Shen, Xingjing Li
BACKGROUND: ANXA2 has been extensively documented in relation to cancer. Nevertheless, the involvement of ANXA2 in lung carcinoma remains uncertain. METHODS: Data from The Cancer Genome Atlas (TCGA) database was downloaded using open-access methods. The examination of publicly available data was conducted utilizing the R software. The mRNA level of specific molecules was detected using Real-time Quantitative PCR (qPCR). The protein level of specific molecules was detected using the Western blot assay...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544610/thyroid-lobectomy-under-local-anesthesia-before-lung-transplantation-owing-to-diffuse-panbronchiolitis-a-case-report
#6
Tsuyoshi Kojima, Yo Kishimoto, Keigo Honda, Atsushi Suehiro, Koichi Omori
We herein report a case of thyroid lobectomy performed under local anesthesia for thyroid cancer in a patient who was at a high risk for general anesthesia due to diffuse panbronchiolitis. Although thyroid surgery has been performed in the past under local anesthesia in low-risk patients, thyroid surgery is now rarely performed under local anesthesia. If they are performed, thyroid surgery under local anesthesia is usually performed under monitored anesthesia care; sedation is considered safe and does not cause discomfort to patients...
February 2024: Curēus
https://read.qxmd.com/read/38544424/cancer-screening-programs-in-japan-progress-and-challenges
#7
REVIEW
Chisato Hamashima, Hirokazu Takahashi
National screening programs for gastric, colorectal, lung, breast, and cervical cancers are offered in Japan. The initial introduction of cancer screening programs was decided based on experts' opinions. Since 2003, the research groups funded by the National Cancer Center have published screening guidelines for gastric, colorectal, lung, prostate, cervical, and breast cancers. Although such guidelines have increasingly contributed to promoting evidence-based screening, it is still insufficient. Cancer screenings have mainly been provided in communities and workplaces...
March 28, 2024: Journal of Medical Screening
https://read.qxmd.com/read/38541827/retrospective-study-of-lung-cancer-evolution-in-16-years-in-the-burgos-region
#8
JOURNAL ARTICLE
Gustavo Gutiérrez Herrero, Sandra Núñez-Rodríguez, Carla Collazo, Álvaro García-Bustillo, Jerónimo J González-Bernal, Lucía Castellanos-Romero, Josefa González-Santos
Background : This study investigates the evolution of lung cancer in the population of Burgos over more than a decade, focusing on key variables such as age, gender, histology, and stage of diagnosis. The aim is to understand how incidence rates and patterns have changed over time, especially in terms of early diagnosis. Methods : Retrospective data were collected from the Burgos University Hospital using histological or clinicoradiological methods. This data collection approach enabled a comprehensive examination of lung cancer trends in the province...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38539548/mutations-in-the-serine-threonine-kinase-braf-oncogenic-drivers-in-solid-tumors
#9
REVIEW
Paola Roa, Nicole Virginia Bremer, Valentina Foglizzo, Emiliano Cocco
Since their discovery in 2002, BRAF mutations have been identified as clear drivers of oncogenesis in several cancer types. Currently, their incidence rate is nearly 7% of all solid tumors with BRAF V600E constituting approximately 90% of these diagnoses. In melanoma, thyroid cancer, and histiocytic neoplasms, BRAF hotspot mutations are found at a rate of about 50%, while in lung and colorectal cancers they range from 3% to 10% of reported cases. Though present in other malignancies such as breast and ovarian cancers, they constitute a small portion of diagnoses (<1%)...
March 20, 2024: Cancers
https://read.qxmd.com/read/38539203/rolapitant-treats-lung-cancer-by-targeting-deubiquitinase-otud3
#10
JOURNAL ARTICLE
Tongde Du, Quan Gu, Yonghui Zhang, Yujie Gan, Rongrui Liang, Wenzhu Yang, Ya Lu, Chenxin Xu, Jianzhong Wu, Rong Ma, Haixia Cao, Jingwei Jiang, Juan Wang, Jifeng Feng
BACKGROUND: Lung cancer is cancer with the highest morbidity and mortality in the world and poses a serious threat to human health. Therefore, discovering new treatments is urgently needed to improve lung cancer prognosis. Small molecule inhibitors targeting the ubiquitin-proteasome system have achieved great success, in which deubiquitinase inhibitors have broad clinical applications. The deubiquitylase OTUD3 was reported to promote lung tumorigenesis by stabilizing oncoprotein GRP78, implying that inhibition of OTUD3 may be a therapeutic strategy for lung cancer...
March 27, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38538642/monolayer-culture-alters-egfr-inhibitor-response-through-abrogation-of-microrna-mediated-feedback-regulation
#11
JOURNAL ARTICLE
Angela Florio, Sarah Johnson, Rebecca Salvatori, George Vasmatzis
Ex vivo drug screening is a potentially powerful tool for the future of cancer care, but the accuracy of results is contingent on the culture model. Both monolayer (2D) and spheroid (3D) culture systems offer advantages, but given the differences in mechanical environment, we hypothesized that that the suitability of one system over another would be critical for screening drugs with mechanical targets in mechanical tissues. HCC827 lung adenocarcinoma cells were challenged with EGFR tyrosine kinase inhibitors in monolayer and spheroid culture...
March 27, 2024: Scientific Reports
https://read.qxmd.com/read/38537159/pack-year-smoking-history-an-inadequate-and-biased-measure-to-determine-lung-cancer-screening-eligibility
#12
JOURNAL ARTICLE
Alexandra L Potter, Nuo N Xu, Priyanka Senthil, Deepti Srinivasan, Hang Lee, G Scott Gazelle, Lydia Chelala, Wei Zheng, Florian J Fintelmann, Lecia V Sequist, Jessica Donington, Julie R Palmer, Chi-Fu Jeffrey Yang
PURPOSE: Pack-year smoking history is an imperfect and biased measure of cumulative tobacco exposure. The use of pack-year smoking history to determine lung cancer screening eligibility in the current US Preventive Services Task Force (USPSTF) guideline may unintentionally exclude many high-risk individuals, especially those from racial and ethnic minority groups. It is unclear whether using a smoking duration cutoff instead of a smoking pack-year cutoff would improve the selection of individuals for screening...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537157/toward-racial-equity-in-lung-cancer-screening-eligibility
#13
EDITORIAL
Hasmeena Kathuria, Renda Soylemez Wiener
No abstract text is available yet for this article.
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38537151/development-and-validation-of-a-machine-learning-prognostic-model-of-m5c-related-immune-genes-in-lung-adenocarcinoma
#14
JOURNAL ARTICLE
Xiong Cao, Yuxing Ji, Jiajia Li, Zhikang Liu, Chang Chen
BACKGROUND: The aim of this retrospective research was to develop an immune-related genes significantly associated with m5C methylation methylation (m5C-IRGs)-related signature associated with lung adenocarainoma (LUAD). METHODS: We introduced transcriptome data to screen out m5C-IRGs in The Cancer Genome Atlas (TCGA)-LUAD dataset. Subsequently, the m5C-IRGs associated with survival were certificated by Kaplan Meier (K-M) analysis. The univariate Cox, least absolute shrinkage and selection operator (LASSO) regression, and xgboost...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38536982/lung-cancer-screening-in-brazil-recommendations-from-the-brazilian-society-of-thoracic-surgery-brazilian-thoracic-association-and-brazilian-college-of-radiology-and-diagnostic-imaging
#15
JOURNAL ARTICLE
Luiz Fernando Ferreira Pereira, Ricardo Sales Dos Santos, Daniel Oliveira Bonomi, Juliana Franceschini, Ilka Lopes Santoro, André Miotto, Thiago Lins Fagundes de Sousa, Rodrigo Caruso Chate, Bruno Hochhegger, Artur Gomes Neto, Airton Schneider, César Augusto de Araújo Neto, Dante Luiz Escuissato, Gustavo Faibischew Prado, Luciana Costa-Silva, Mauro Musa Zamboni, Mario Claudio Ghefter, Paulo César Rodrigues Pinto Corrêa, Pedro Paulo Teixeira E Silva Torres, Ricardo Kalaf Mussi, Valdair Francisco Muglia, Irma de Godoy, Wanderley Marques Bernardo
Although lung cancer (LC) is one of the most common and lethal tumors, only 15% of patients are diagnosed at an early stage. Smoking is still responsible for more than 85% of cases. Lung cancer screening (LCS) with low-dose CT (LDCT) reduces LC-related mortality by 20%, and that reduction reaches 38% when LCS by LDCT is combined with smoking cessation. In the last decade, a number of countries have adopted population-based LCS as a public health recommendation. Albeit still incipient, discussion on this topic in Brazil is becoming increasingly broad and necessary...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536829/the-effects-of-gases-from-food-waste-on-human-health-a-systematic-review
#16
JOURNAL ARTICLE
Paulina Rudziak, Evans Batung, Isaac Luginaah
Food waste is a routine and increasingly growing global concern that has drawn significant attention from policymakers, climate change activists and health practitioners. Amid the plurality of discourses on food waste-health linkages, however, the health risks from food waste induced emissions have remained under explored. This lack of evidence is partly because of the lack of complete understanding of the effects of food waste emissions from household food waste on human health either directly through physiological mechanisms or indirectly through environmental exposure effects...
2024: PloS One
https://read.qxmd.com/read/38536463/enhancing-a-deep-learning-model-for-pulmonary-nodule-malignancy-risk-estimation-in-chest-ct-with-uncertainty-estimation
#17
JOURNAL ARTICLE
Dré Peeters, Natália Alves, Kiran V Venkadesh, Renate Dinnessen, Zaigham Saghir, Ernst T Scholten, Cornelia Schaefer-Prokop, Rozemarijn Vliegenthart, Mathias Prokop, Colin Jacobs
OBJECTIVE: To investigate the effect of uncertainty estimation on the performance of a Deep Learning (DL) algorithm for estimating malignancy risk of pulmonary nodules. METHODS AND MATERIALS: In this retrospective study, we integrated an uncertainty estimation method into a previously developed DL algorithm for nodule malignancy risk estimation. Uncertainty thresholds were developed using CT data from the Danish Lung Cancer Screening Trial (DLCST), containing 883 nodules (65 malignant) collected between 2004 and 2010...
March 27, 2024: European Radiology
https://read.qxmd.com/read/38535442/natural-products-derived-from-marine-sponges-with-antitumor-potential-against-lung-cancer-a-systematic-review
#18
REVIEW
Alba Ortigosa-Palomo, Francisco Quiñonero, Raul Ortiz, Francisco Sarabia, Jose Prados, Consolación Melguizo
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient survival. In this context, marine animals are a source of new, interesting bioactive molecules that have been applied to the treatment of different types of cancer. Many efforts have been made to search for new therapeutic strategies to improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic drugs from marine sponges...
February 23, 2024: Marine Drugs
https://read.qxmd.com/read/38534949/wedge-resection-versus-stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer-tumors-%C3%A2-8-mm
#19
JOURNAL ARTICLE
Arian Mansur, Zain Saleem, Jorind Beqari, Camille Mathey-Andrews, Alexandra L Potter, James Cranor, Alexandra T Nees, Deepti Srinivasan, Margaret E Yang, Chi-Fu Jeffrey Yang, Hugh G Auchincloss
The objective of this study was to evaluate the overall survival of patients with ≤8 mm non-small cell lung cancer (NSCLC) who undergo wedge resection versus stereotactic body radiation therapy (SBRT). Kaplan-Meier analysis, multivariable Cox proportional hazards modeling, and propensity score-matched analysis were performed to evaluate the overall survival of patients with ≤8 mm NSCLC in the National Cancer Database (NCDB) from 2004 to 2017 who underwent wedge resection versus patients who underwent SBRT...
March 15, 2024: Current Oncology
https://read.qxmd.com/read/38533033/elucidating-the-anti-cancer-potential-of-cinnamomum-tamala-essential-oil-against-non-small-cell-lung-cancer-a-multifaceted-approach-involving-gc-ms-profiling-network-pharmacology-and-molecular-dynamics-simulations
#20
JOURNAL ARTICLE
Debajani Mohanty, Sucheesmita Padhee, Arpita Priyadarshini, Bibhuti Bhusan Champati, Prabhat Kumar Das, Sudipta Jena, Ambika Sahoo, Pratap Chandra Panda, Sanghamitra Nayak, Asit Ray
Cinnamomum tamala (Buch.-Ham.) T.Nees & Eberm., or Indian Bay Leaf, is a well-known traditional ayurvedic medicine used to treat various ailments. However, the molecular mechanism of action of Cinnamomum tamala essential oil (CTEO) against non-small cell lung cancer (NSCLC) remains elusive. The present study aims to decipher the molecular targets and mechanism of CTEO in treating NSCLC. GC-MS analysis detected 49 constituents; 44 successfully passed the drug-likeness screening and were identified as active compounds...
March 30, 2024: Heliyon
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