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https://www.readbyqxmd.com/read/29691812/excipient-selection-and-aerodynamic-characterization-of-nebulized-lipid-based-nanoemulsion-loaded-with-docetaxel-for-lung-cancer-treatment
#1
Azren Aida Asmawi, Norazlinaliza Salim, Cheng Loong Ngan, Haslina Ahmad, Emilia Abdulmalek, Mas Jaffri Masarudin, Mohd Basyaruddin Abdul Rahman
Docetaxel has demonstrated extraordinary anticancer effects on lung cancer. However, lack of optimal bioavailability due to poor solubility and high toxicity at its therapeutic dose has hampered the clinical use of this anticancer drug. Development of nanoemulsion formulation along with biocompatible excipients aimed for pulmonary delivery is a potential strategy to deliver this poorly aqueous soluble drug with improved bioavailability and biocompatibility. In this work, screening and selection of pharmaceutically acceptable excipients at their minimal optimal concentration have been conducted...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29690722/-dynamic-investigation-of-nutritional-risk-in-patients-with-malignant-tumor-during-hospitalization
#2
M W Zhu, J M Wei, W Chen, X Yang, H Y Cui, S N Zhu, P P Zhang, J Xiong, D F Zheng, H J Song, X Y Liang, L Zhang, W Y Xu, H B Wang, G Q Su, L J Feng, T Chen, Y D Wu, H Li, J Q Sun, Y Shi, B D Tong, S M Zhou, X Y Wang, Y H Huang, B M Zhang, J Xu, H Y Zhang, G L Chang, Z Y Jia, S F Chen, J Hu, X W Zhang, H Wang, Z D Li, Y Y Gao, B Gui
Objective: To prospectively investigate the changes in nutritional status of patients with malignant tumors during hospitalization by using nutritional risk screening (NRS2002), and to analyze the correlation between the nutritional status and clinical outcomes . Methods: This was a prospective and parallel research done by multi-center collaboration from 34 hospitals in China from June to September 2014.Hospitalized patients with malignant tumors inthese departments (Department of Gastroenterology, respiratory medicine, oncology, general surgery, thoracic surgery and geriatrics)were investigated...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29689480/the-need-to-be-all-inclusive-chest-ct-scans-should-include-imaged-breast-parenchyma
#3
EDITORIAL
Mary Salvatore, Laurie Margolies, Alexandra Bertolini, Ayushi Singh, David Yankelevitz, Claudia Henschke
The benefits of early diagnosis and treatment of breast cancer are well established. Thoracic CT which is performed with increased frequency for lung cancer screening can diagnose breast cancer earlier then might be possible clinically. The imaged and radiation exposed breasts must be included in their entirety on images which are reviewed by the radiologist. Because of concerns about how altering the field of view might affect image quality, we advocate for inclusion of the entire breast on the soft tissue series, which can be viewed on mediastinal window settings and expose the patient to no additional radiation...
April 19, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29689434/estimating-the-cost-effectiveness-of-lung-cancer-screening-with-low-dose-computed-tomography-for-high-risk-smokers-in-australia
#4
Stephen Wade, Marianne Weber, Michael Caruana, Yoon-Jung Kang, Henry Marshall, Renee Manser, Shalini Vinod, Nicole Rankin, Kwun Fong, Karen Canfell
BACKGROUND: Health economic evaluations of lung cancer screening with low dose computerised tomography (LDCT) that are underpinned by clinical outcomes are few. METHODS: We assessed the cost-effectiveness of LDCT lung screening in Australia by applying Australian cost and survival data to the outcomes observed in the U.S. National Lung Screening Trial (NLST), in which a 20% lung cancer mortality benefit was demonstrated for three rounds of annual screening among high-risk smokers aged 55-74 years...
April 21, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29687154/erlotinib-in-routine-clinical-practice-for-first-line-maintenance-therapy-in-patients-with-advanced-non-small-cell-lung-cancer-nsclc
#5
M Faehling, J Achenbach, P Staib, U Steffen, H W Tessen, V E Gaillard, W Brugger
PURPOSE: The controlled phase III trial SATURN demonstrated that maintenance therapy with erlotinib after the first-line platinum-based chemotherapy prolonged progression-free survival (PFS) and overall survival (OS) of non-small cell lung cancer (NSCLC) patients with advanced, non-progressive disease. We conducted the non-interventional study SATURN NIS to investigate the effectiveness and tolerability of erlotinib maintenance in daily clinical practice. METHODS: This single-arm NIS screened 290 patients with locally advanced or metastatic NSCLC (stage IIIB or IV) and stable disease after standard platinum-based first-line chemotherapy in 95 institutions across Germany...
April 23, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29683843/benefits-and-harms-of-lung-cancer-screening-in-hiv-infected-individuals-with-cd4-%C3%A2-500-a-simulation-study
#6
Chung Yin Kong, Keith Sigel, Steven D Criss, Deirdre F Sheehan, Matthew Triplette, Michael J Silverberg, Claudia I Henschke, Amy Justice, R Scott Braithwaite, Juan Wisnivesky, Kristina Crothers
OBJECTIVE: Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals. DESIGN: We modified an existing simulation model, the Lung Cancer Policy Model, for HIV-infected patients...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29681140/physician-s-awareness-of-lung-cancer-screening-and-its-related-medical-radiation-exposure-in-korea
#7
Seri Hong, Suyeon Kim, Mina Suh, Boyoung Park, Kui Son Choi, Jae Kwan Jun
OBJECTIVES: Through a survey on perception of lung cancer screening and accompanying medical radiation exposure in Korea, the present study was to investigate its current situations and evaluate various perception of physicians regarding it in order to propose measures for improvements. METHODS: Medical specialists in national cancer screening institutions selected through stratified random sampling were subjected to face-to-face interview using a structured questionnaire...
2018: Epidemiology and Health
https://www.readbyqxmd.com/read/29679265/focus-groups-and-in-depth-interviews-to-guide-the-development-of-lung-cancer-screening-informational-materials
#8
Anushree Sharma, Richard O'Connor, Paula Celestino, Samantha Killion, Laurie Griswold-Krupski, Maansi Bansal-Travers
Lung cancer is one of the most lethal cancers in the USA. In 2013, new guidelines issued by the United States Preventive Services Task Force recommended lung cancer screening using low-dose computed tomography among a selected group of high-risk individuals. Specifically, lung cancer screening is recommended for heavy smokers between the ages of 55 to 79, with at least 30 pack-year smoking exposure. Former smokers who meet these guidelines and stopped smoking ≤ 15 years ago are also eligible. There is a need to promote lung cancer screening to increase early diagnosis rates and treatment options, thereby decreasing disease-specific mortality...
April 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29678941/autoantibodies-and-scleroderma-phenotype-define-subgroups-at-high-risk-and-low-risk-for-cancer
#9
Takeru Igusa, Laura K Hummers, Kala Visvanathan, Carrie Richardson, Fredrick M Wigley, Livia Casciola-Rosen, Antony Rosen, Ami A Shah
OBJECTIVES: Recent studies demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma. Investigating cancer risk in these biologically relevant subsets may provide an opportunity to develop personalised cancer screening guidelines. In this study, we examined cancer risk in distinct serologic and phenotypic scleroderma subsets and compared estimates with the general population. METHODS: Patients in the Johns Hopkins Scleroderma Center observational cohort were studied...
April 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29678767/targeted-inhibition-of-tumor-survival-metastasis-and-angiogenesis-by-acacia-ferruginea-mediated-regulation-of-vegf-inflammatory-mediators-cytokine-profile-and-inhibition-of-transcription-factor-activation
#10
Kunnathur Murugesan Sakthivel, Chandrasekaran Guruvayoorappan
Acacia ferruginea extract (AFE) was studied for anti-metastasis/-angiogenesis activity against B16F-10 melanoma cells in C57BL/6 mice. In vitro cytotoxicity of AFE was first screened using MTT assay and it was shown to inhibit B16F-10 cells with IC50 value of 52.94 μg/ml. Anti-metastatic activity of AFE in vivo revealed administration of AFE (10 mg/kg.b.wt) in three different regimens has shown reduced metastatic colony formation in lungs and prolonged survival in metastatic tumor-bearing hosts. Biochemical analysis shown that treatment with AFE significantly reduced the lung collagen hydroxyproline, hexosamine, uronic acid, sialic acid and gamma-glutamyl transpeptidase content...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29678673/a-validated-clinical-risk-prediction-model-for-lung-cancer-in-smokers-of-all-ages-and-exposure-types-a-hunt-study
#11
Maria Markaki, Ioannis Tsamardinos, Arnulf Langhammer, Vincenzo Lagani, Kristian Hveem, Oluf Dimitri Røe
Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population study in Norway examined 65,237 people aged >20years in 1995-97. After a median of 15·2years, 583 lung cancer cases had been diagnosed; 552 (94·7%) ever-smokers and 31 (5·3%) never-smokers. We performed multivariable analyses of 36 candidate risk predictors, using multiple imputation of missing data and backwards feature selection with Cox regression...
March 30, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29677642/diagnostic-value-of-18-f-fluordesoxyglucose-positron-emission-tomography-for-patients-with-brain-metastasis-from-unknown-primary-site
#12
Fabian Wolpert, Michael Weller, Anna Sophie Berghoff, Elisabeth Rushing, Lisa Michaela Füreder, Gregory Petyt, Henning Leske, Nicolaus Andratschke, Luca Regli, Marian Christoph Neidert, Roger Stupp, Rolf Stahel, Reinhard Dummer, Thomas Frauenfelder, Patrick Roth, Nicolas Reyns, Philipp Antonio Kaufmann, Matthias Preusser, Emilie Le Rhun
BACKGROUND: In 30% of patients with brain metastasis (BM), neurological symptoms are the first clinical manifestation of systemic malignancy, referred to as BM from cancer of unknown primary site (BM-CUPS). Here, we define the diagnostic value of 18 F-fluordesoxyglucose positron emission tomography (FDG-PET/CT) in the workup of BM-CUPS. METHODS: We screened 565 patients operated for BM at the University Hospital Zurich and identified 64 patients with BM-CUPS with data on both FDG-PET/CT and contrast-enhanced chest/abdomen computed tomography (CT) available at BM diagnosis...
April 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29677028/treatment-of-tobacco-dependence-current-state-of-the-art
#13
Hasmeena Kathuria, Frank T Leone, Enid R Neptune
PURPOSE OF REVIEW: The Centers for Medicare and Medicaid Services' requirement to integrate tobacco treatment with lung cancer screening (LCS) has served as a catalyst for motivating pulmonary medicine clinicians to improve upon their ability to effectively treat tobacco dependence. To do so, clinicians need to be well versed in the behavioral and pharmacologic tools that promote smoking cessation. RECENT FINDINGS: The current review outlines current strategies for treating tobacco dependence, focusing on the important interplay between counseling and pharmacotherapy...
April 18, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29675281/coexistent-non-small-cell-carcinoma-and-small-cell-carcinoma-in-a-patient-presenting-with-hyponatremia
#14
Mitchell D Ross, Sreeja Biswas Roy, Pradnya D Patil, Jasmine L Huang, Nitika Thawani, Ralph Drosten, Tanmay S Panchabhai
Despite recent advances in screening methods, lung cancer remains the leading cause of cancer-related deaths worldwide. By the time lung cancer becomes symptomatic and patients seek treatment, it is often too advanced for curative measures. Low-dose computed tomography (CT) screening has been shown to reduce mortality in patients at high risk of lung cancer. We present a 66-year-old man with a 50-pack-year smoking history who had a right upper lobe (RUL) pulmonary nodule and left lower lobe (LLL) consolidation on a screening CT...
2018: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29669694/discovery-of-novel-serine-palmitoyltransferase-inhibitors-as-cancer-therapeutic-agents
#15
Takuto Kojima, Yasutomi Asano, Osamu Kurasawa, Yasuhiro Hirata, Naoki Iwamura, Tzu-Tshin Wong, Bunnai Saito, Yuta Tanaka, Ryosuke Arai, Kazuko Yonemori, Yasufumi Miyamoto, Yoji Sagiya, Masahiro Yaguchi, Sachio Shibata, Akio Mizutani, Osamu Sano, Ryutaro Adachi, Yoshinori Satomi, Megumi Hirayama, Kazunobu Aoyama, Yuto Hiura, Atsushi Kiba, Shuji Kitamura, Shinichi Imamura
We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and growth suppression of cancer cells. High-throughput screening and medicinal chemistry efforts led to the identification of structurally diverse SPT inhibitors 4 and 5. Both compounds potently inhibited SPT enzyme and decreased intracellular ceramide content. In addition, they suppressed cell growth of human lung adenocarcinoma HCC4006 and acute promyelocytic leukemia PL-21, and displayed good pharmacokinetic profiles...
April 4, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29667778/dna-methylation-biomarkers-for-the-occurrence-of-lung-adenocarcinoma-from-tcga-data-mining
#16
Xiao-Feng Zhu, Bi-Sheng Zhu, Fei-Ma Wu, Hai-Bo Hu
The development of lung cancer is a combination of multifactor, multistage, and multiple genetic alterations processes. DNA methylation is an important factor. Currently, the study on the genome-scale epigenetic modification for studying the pathogenesis of lung cancer is still lacking. Here, we aimed to identify the epigenetic modifications of lung cancer, thus to provide scientific basis for the personalized medicine, and research of classification screening for lung adenocarcinoma patients. The DNA methylation data, and the corresponding clinical information of lung adenocarcinoma samples were extracted from the Cancer Genome Atlas (TCGA) database...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667217/secondary-prostate-cancer-screening-outcomes-by-race-in-the-prostate-lung-colorectal-and-ovarian-plco-screening-trial
#17
Eric A Miller, Paul F Pinsky, Amanda Black, Gerald L Andriole, Dudith Pierre-Victor
BACKGROUND: Despite disparities in prostate cancer incidence and mortality rates between black and white men, there is still insufficient data available to assess potential differences in the benefits and harms of prostate cancer screening by race. Although the Prostate, Lung, Colorectal, and Ovarian (PLCO) Screening Trial is underpowered to detect a difference by race in prostate-cancer specific mortality, because of the large study size, there are still sufficient numbers to examine secondary screening outcomes...
April 17, 2018: Prostate
https://www.readbyqxmd.com/read/29667003/chemical-genomics-reveals-inhibition-of-breast-cancer-lung-metastasis-by-ponatinib-via-c-jun
#18
Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang, Dong Wang
Metastasis is the leading cause of human cancer deaths. Unfortunately, no approved drugs are available for anti-metastatic treatment. In our study, high-throughput sequencing-based high-throughput screening (HTS2 ) and a breast cancer lung metastasis (BCLM)-associated gene signature were combined to discover anti-metastatic drugs. After screening of thousands of compounds, we identified Ponatinib as a BCLM inhibitor. Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models...
April 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29666814/digital-chest-tomosynthesis-the-2017-updated-review-of-an-emerging-application
#19
REVIEW
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666813/ground-glass-opacities-management-in-the-lung-cancer-screening-era
#20
REVIEW
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Paolo Vigneri, Marco Nardini, Joel Dunning
Pulmonary ground glass opacity (GGO) is becoming an important clinical dilemma in oncology as its diagnosis in clinical practice is increasing due to the introduction of low dose computed tomography (CT) scan and screening. The incidence of cancer in GGO has been reported as high as 63%. The purpose of this manuscript is to review best available evidence papers on management of GGO in lung cancer to address the following questions: (I) how to correlate CT findings with malignancy; (II) when and who operate? (III) how to perform intraoperative detection of intrapulmonary GGO? (IV) wedge, segmentectomy or lobectomy? Taking a cue from a clinical scenario, a review on PubMed was conducted...
March 2018: Annals of Translational Medicine
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