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https://www.readbyqxmd.com/read/28644772/risk-stratification-for-second-primary-lung-cancer
#1
Summer S Han, Gabriel A Rivera, Martin C Tammemägi, Sylvia K Plevritis, Scarlett L Gomez, Iona Cheng, Heather A Wakelee
Purpose This study estimated the 10-year risk of developing second primary lung cancer (SPLC) among survivors of initial primary lung cancer (IPLC) and evaluated the clinical utility of the risk prediction model for selecting eligibility criteria for screening. Methods SEER data were used to identify a population-based cohort of 20,032 participants diagnosed with IPLC between 1988 and 2003 and who survived ≥ 5 years after the initial diagnosis. We used a proportional subdistribution hazards model to estimate the 10-year risk of developing SPLC among survivors of lung cancer LC in the presence of competing risks...
June 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28644424/the-indirect-efficacy-comparison-of-dna-methylation-in-sputum-for-early-screening-and-auxiliary-detection-of-lung-cancer-a-meta-analysis
#2
REVIEW
Di Liu, Hongli Peng, Qi Sun, Zhongyao Zhao, Xinwei Yu, Siqi Ge, Hao Wang, Honghong Fang, Qing Gao, Jiaonan Liu, Lijuan Wu, Manshu Song, Youxin Wang
BACKGROUND: DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer. MATERIALS AND METHODS: Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28644254/sporadic-creutzfeldt-jakob-disease-with-unilateral-symptoms-in-the-setting-of-metastatic-renal-cell-carcinoma
#3
Kyle C Rossi, Christine M Stahl, Pengfei Zhang, John W Liang, Lara V Marcuse, Fred Lublin
INTRODUCTION: Although it is not rare for magnetic resonance imaging findings in Creutzfeldt-Jakob disease to be asymmetric, unilateral clinical syndromes are uncommonly reported and may confound diagnosis. In addition, neurological paraneoplastic syndromes are not common in renal cell carcinoma, though there are cases reported, often without an offending antibody isolated. CASE REPORT: A 66-year-old man was admitted with 1 month of left-sided numbness and "loss of control" of the left arm...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28643093/the-impact-of-trained-radiographers-as-concurrent-readers-on-performance-and-reading-time-of-experienced-radiologists-in-the-uk-lung-cancer-screening-ukls-trial
#4
Arjun Nair, Nicholas J Screaton, John A Holemans, Diane Jones, Leigh Clements, Bruce Barton, Natalie Gartland, Stephen W Duffy, David R Baldwin, John K Field, David M Hansell, Anand Devaraj
OBJECTIVES: To compare radiologists' performance reading CTs independently with their performance using radiographers as concurrent readers in lung cancer screening. METHODS: 369 consecutive baseline CTs performed for the UK Lung Cancer Screening (UKLS) trial were double-read by radiologists reading either independently or concurrently with a radiographer. In concurrent reading, the radiologist reviewed radiographer-identified nodules and then detected any additional nodules...
June 22, 2017: European Radiology
https://www.readbyqxmd.com/read/28640902/hepatitis-b-virus-reactivation-and-antiviral-prophylaxis-during-lung-cancer-chemotherapy-a-systematic-review-and-meta-analysis
#5
Yu-Tuan Wu, Xin Li, Zi-Li Liu, Zhou Xu, Wei Dai, Ke Zhang, Jiu-Song Wu, Bilal Arshad, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: Antiviral drugs have been recommended as prophylaxis for the reactivation of hepatitis B virus (HBV) infection in cancer patients undergoing chemotherapy. However, screening and antiviral prophylaxis for lung cancer remain controversial because of insufficient evidence. PURPOSE: In this study, we investigate the absolute risk for HBV reactivation and the prophylactic effects of antiviral drugs in hepatitis B surface antigen (HBsAg)-positive lung cancer patients during chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28640670/rationale-and-design-of-the-lung-cancer-screening-implementation-evaluation-of-patient-centered-care-study
#6
Leah S Miranda, Santanu Datta, Anne C Melzer, Renda Soylemez Wiener, James M Davis, Betty C Tong, Sara E Golden, Christopher G Slatore
Screening for lung cancer using low-dose computed tomography (LDCT) has been demonstrated to reduce lung cancer-related mortality and is being widely implemented. Further research in this area is needed to assess the impact of screening on patient-centered outcomes. Here we describe the design and rationale for a new study entitled Lung Cancer Screening Implementation: Evaluation of Patient-Centered Care. The protocol is composed of an interconnected series of studies evaluating patients and clinicians who are engaged in lung cancer screening in real-world settings...
June 22, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28637439/a-qualitative-analysis-of-smokers-perceptions-about-lung-cancer-screening
#7
Lindsay Gressard, Amy S DeGroff, Thomas B Richards, Stephanie Melillo, Julia Kish-Doto, Christina L Heminger, Elizabeth A Rohan, Kristine Gabuten Allen
BACKGROUND: In 2013, the US Preventive Services Task Force (USPSTF) began recommending lung cancer screening for high risk smokers aged 55-80 years using low-dose computed tomography (CT) scan. In light of these updated recommendations, there is a need to understand smokers' knowledge of and experiences with lung cancer screening in order to inform the design of patient education and tobacco cessation programs. The purpose of this study is to describe results of a qualitative study examining smokers' perceptions around lung cancer screening tests...
June 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28637019/clinicopathological-characteristics-of-ros1-and-ret-rearranged-nsclc-in-caucasian-patients-data-from-a-cohort-of-713-non-squamous-nsclc-lacking-kras-egfr-her2-braf-pik3ca-alk-alterations
#8
Frédéric Dugay, Francisco Llamas-Gutierrez, Marjory Gournay, Sarah Medane, François Mazet, Dan Christian Chiforeanu, Emmanuelle Becker, Régine Lamy, Hervé Léna, Nathalie Rioux-Leclercq, Marc-Antoine Belaud-Rotureau, Florian Cabillic
Targeted therapies have substantially changed the management of non-small cell lung cancer (NSCLC) patients with driver oncogenes. Given the high frequency, EGFR and ALK aberrations were the first to be detected and paved the way for tyrosine kinase inhibitor (TKI) treatments. Other kinases such as ROS1 and more recently RET have emerged as promising targets, and ROS1 and RET TKIs are already available for precision medicine.We screened a large cohort of 713 Caucasian non-squamous NSCLC patients lacking EGFR/KRAS/BRAF/HER2/PI3KCA/ALK aberrations for ROS1 and RET rearrangements using fluorescence in situ hybridization to determine the frequency and clinicopathological characteristics of ROS1- and RET-positive patients...
June 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28637014/a-combination-of-valproic-acid-sodium-salt-chir99021-e-616452-tranylcypromine-and-3-deazaneplanocin-a-causes-stem-cell-like-characteristics-in-cancer-cells
#9
Shuang Sha, Yuanfen Zhai, Chengzhao Lin, Heyong Wang, Qing Chang, Shuang Song, Mingqiang Ren, Gentao Liu
Many studies are based on the hypothesis that recurrence and drug resistance in lung carcinoma are due to a subpopulation of cancer stem-like cells (CSLCs) in solid tumors. Therefore it is crucial to screen for and recognize lung CSLCs. In this study, we stimulated non-small cell lung cancer (NSCLC) A549 cells to display stem cell-like characteristics using a combination of five small molecule compounds. The putative A549 stem cells activated an important CSLC marker, CD133 protein, as well multiple CSLC-related genes including ATP-binding cassette transporter G2 (ABCG2), C-X-C chemokine receptor type 4 (CXCR4), NESTIN, and BMI1...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28635245/focus-on-lung-cancer-screening-program-at-campus-bio-medico-of-rome-update-on-over-3250-patients
#10
Giuseppe Mangiameli, Filippo Longo, Rosario F Grasso, Antonino Iacopino, Raffaele Rocco, Fabio Quintarelli, Pierfilippo Crucitti
No abstract text is available yet for this article.
August 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28634123/clinical-utility-of-chromosomal-aneusomy-in-individuals-at-high-risk-of-lung-cancer
#11
Anna E Barón, Severine Kako, William J Feser, Heather Malinowski, Daniel Merrick, Kavita Garg, Stephen Malkoski, Shannon Pretzel, Jill M Siegfried, Wilbur A Franklin, York Miller, Holly J Wolf, Marileila Varella-Garcia
INTRODUCTION: Low dose CT screening for lung cancer has a high false positive rate with frequent discovery of indeterminate pulmonary nodules. Noninvasive biomarkers are needed to reduce false positives and improve risk stratification. A retrospective longitudinal evaluation was performed to assess chromosomal aneusomy in sputum via fluorescence in situ hybridization (CA-FISH) in four nested case-control studies. METHODS: ROC analysis resulted in two grouped cohorts: High Risk (CO High Risk and CO Nodule; 68 Cases, 69 controls) and Screening (ACRIN/NLST and PLuSS; 97 Cases, 185 controls)...
June 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28631571/a-truncated-p53-in-human-lung-cancer-cells-as-a-critical-determinant-of-proliferation-and-invasiveness
#12
Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hui Wang
As a transcription factor, p53 must accumulate in the nucleus to be effective. Signals related to nuclear localization are distributed mainly in the C-terminal of p53. So these nuclear location domains were reserved and the other part of the C-terminal was removed in this study. We investigated whether the truncated p53 (p53(DEL)) may affect proliferation and invasive potential of human lung cancer cells. H1299 and 801D cells expressing full-length p53 and the p53(DEL) were obtained by screening. Cell proliferation assay, cell apoptotic analysis, cell migration assay, and invasion assay were performed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28630806/prevalence-and-barriers-to-lung-cancer-screening-in-karachi-pakistan-a-cross-sectional-survey-of-smokers-and-physicians
#13
Aleeza Abbasi, Rabbia Siddiqi, Aatika Owais, Tooba Laeeq, Sara N Ali, Zonaira Mushahid, Syed M Ahsan, Aliya S Jatoi, Aleena Abbasi, Ifrah Butt, Ruba Ali, Maham Abbasi, Syeda Naintara N Jaffri, Mariam Jabir, Hajra Khanani, Kaneez Fatima
BACKGROUND: Early detection of lung cancer using low-dose computed tomography (LDCT) can potentially reduce morbidity and mortality. However, LDCT for lung cancer screening, especially in low income countries, has been underutilized. The objective of this study was to evaluate the prevalence and the potential personal, social, and economic barriers of lung cancer screening using LDCT. METHODS: A total sample of 156 smokers and 200 general physicians was collected during December 2016-February 2017 from community settings in Karachi, Pakistan...
May 15, 2017: Curēus
https://www.readbyqxmd.com/read/28629461/cost-effectiveness-of-lung-cancer-screening-and-treatment-methods-a-systematic-review-of-systematic-reviews
#14
Farbod Ebadifard Azar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Alireza Mazdaki, Aziz Rezapour, Parvin Ebrahimi, Negar Yousefzadeh
BACKGROUND: Due to extensive literature in the field of lung cancer and their heterogeneous results, the aim of this study was to systematically review of systematic reviews studies which reviewed the cost-effectiveness of various lung cancer screening and treatment methods. METHODS: In this systematic review of systematic reviews study, required data were collected searching the following key words which selected from Mesh: "lung cancer", "lung oncology", "lung Carcinoma", "lung neoplasm", "lung tumors", "cost- effectiveness", "systematic review" and "Meta-analysis"...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28628709/maximizing-benefits-and-minimizing-harms-of-lung-cancer-screening-a-teachable-moment
#15
Jason N Mansoori, Nathaniel Little, Stephen P Malkoski
No abstract text is available yet for this article.
June 19, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28627945/-model-concept-of-the-health-economic-evaluation-of-low-dose-ct-lung-cancer-screening-in-hungary
#16
Zoltán Vokó, Magdolna Barra, Anett Molnár, Anna Kerpel-Fronius, Gábor Bajzik, Ildikó Horváth, Mariann Moizs, Balázs Nagy
INTRODUCTION: Lung cancer is a rapidly progressing, often life-threatening disease that constitutes a huge societal burden. Because of the scarce resources of the Hungarian health care system, the cost-effectiveness of introducing low-dose computed tomography screening is a relevant health policy matter. AIM: The aim of this study is to design a model concept for assessing the cost-effectiveness of low-dose computed tomography lung cancer screening in Hungary, and to define the required steps for performing the analysis...
June 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28627833/comparison-of-the-analytical-performance-between-cobas-egfr-assay-and-pcr-clamp-method-in-the-detection-of-egfr-mutations-in-japanese-non-small-cell-lung-cancer-patients
#17
Tomohiko Ai, Maiko Yuri, Yoko Tabe, Atsushi Kakimoto, Soji Morishita, Koji Tsuchiya, Kazuya Takamochi, Yuzo Kodama, Fumiyuki Takahashi, Misawa Shigeki, Takashi Horii, Kenji Suzuki, Kazuhisa Takahashi, Takashi Miida, Akimichi Ohsaka
BACKGROUND: EGFR, a tyrosine-kinase, plays an important role in the progression of lung cancer. Since genetic abnormality of EGFR alters the effects of tyrosine-kinase inhibitors targeting EGFR, molecular analyses of EGFR have recently gained more attention in the treatment of lung cancer. However, several different techniques are available and which method is superior has not been determined. In this study, we compared two recently developed PCR-based techniques, PCR-clamp method and cobas EGFR assay...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627685/metabolomic-analysis-based-on-1h-nuclear-magnetic-resonance-spectroscopy-metabolic-profiles-in-tuberculous-malignant-and-transudative-pleural-effusion
#18
Cheng Wang, Jingjin Peng, Yanling Kuang, Jiaqiang Zhang, Luming Dai
Pleural effusion is a common clinical manifestation with various causes. Current diagnostic and therapeutic methods have exhibited numerous limitations. By involving the analysis of dynamic changes in low molecular weight catabolites, metabolomics has been widely applied in various types of disease and have provided platforms to distinguish many novel biomarkers. However, to the best of our knowledge, there are few studies regarding the metabolic profiling for pleural effusion. In the current study, 58 pleural effusion samples were collected, among which 20 were malignant pleural effusions, 20 were tuberculous pleural effusions and 18 were transudative pleural effusions...
June 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625647/quantification-of-growth-patterns-of-screen-detected-lung-cancers-the-nelson-study
#19
Marjolein A Heuvelmans, Rozemarijn Vliegenthart, Harry J de Koning, Harry J M Groen, Michel J A M van Putten, Uraujh Yousaf-Khan, Carla Weenink, Kristiaan Nackaerts, Pim A de Jong, Matthijs Oudkerk
OBJECTIVES: Although exponential growth is assumed for lung cancer, this has never been quantified in vivo. Aim of this study was to evaluate and quantify growth patterns of lung cancers detected in the Dutch-Belgian low-dose computed tomography (CT) lung cancer screening trial (NELSON), in order to elucidate the development and progression of early lung cancer. MATERIALS AND METHODS: Solid lung nodules found at ≥3 CT examinations before lung cancer diagnosis were included...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28625633/cost-effectiveness-of-implementing-computed-tomography-screening-for-lung-cancer-in-taiwan
#20
Szu-Chun Yang, Wu-Wei Lai, Chien-Chung Lin, Wu-Chou Su, Li-Jung Ku, Jing-Shiang Hwang, Jung-Der Wang
BACKGROUND: A screening program for lung cancer requires more empirical evidence. Based on the experience of the National Lung Screening Trial (NLST), we developed a method to adjust lead-time bias and quality-of-life changes for estimating the cost-effectiveness of implementing computed tomography (CT) screening in Taiwan. METHODS: The target population was high-risk (≥30 pack-years) smokers between 55 and 75 years of age. From a nation-wide, 13-year follow-up cohort, we estimated quality-adjusted life expectancy (QALE), loss-of-QALE, and lifetime healthcare expenditures per case of lung cancer stratified by pathology and stage...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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