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https://www.readbyqxmd.com/read/29146227/bariatric-surgery-improves-lipoprotein-profile-in-morbidly-obese-patients-by-reducing-ldl-cholesterol-apob-and-saa-pon1-ratio-increasing-hdl-cholesterol-but-has-no-effect-on-cholesterol-efflux-capacity
#1
Christian Abendstein Kjellmo, Helen Karlsson, Torunn K Nestvold, Stefan Ljunggren, Karin Cederbrant, Maritha Marcusson-Ståhl, Monica Mathisen, Knut Tore Lappegård, Anders Hovland
BACKGROUND: Bariatric surgery has been shown to reduce cardiovascular events and cause-specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to be of value in cardiovascular risk assessment. OBJECTIVES: The objective of this study was to examine the effect of a lifestyle intervention followed by bariatric surgery on the lipid profile of morbidly obese patients...
November 8, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28987899/plasma-lipoproteins-in-posttraumatic-stress-disorder-patients-compared-to-healthy-controls-and-their-associations-with-the-hpa-and-hpt-axis
#2
Giel-Jan de Vries, Roel Mocking, Johanna Assies, Aart Schene, Miranda Olff
BACKGROUND: Based on studies among primarily male veteran subjects, lipoproteins are thought to mediate the association of posttraumatic stress disorder (PTSD) with cardiovascular disease (CVD). However, recent civilian studies with female samples or samples with both sexes represented provide little evidence for this association. Gender, diet and sex-specific effects of stress hormones on lipoproteins may explain this dissociation in findings. METHOD: Cross-sectional analysis of plasma concentrations of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG) in a male and female sample of 49 PTSD-patients due to civilian trauma and 45 healthy controls...
December 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28969178/association-of-serum-lipids-with-hepatic-steatosis-stage-of-liver-fibrosis-and-viral-load-in-chronic-hepatitis-c
#3
Ivan Valkov, Radina Ivanova, Assen Alexiev, Krasimir Antonov, Lyudmila Mateva
INTRODUCTION: Hepatitis C Virus (HCV) relies on host lipids for its life cycle contributing to lipid abnormalities and hepatic steatosis. Disease progression is influenced by viral factors interacting with host immune and metabolic pathways. The significance of serum lipids for Chronic Hepatitis C (CHC) assessment is not clearly established yet. AIM: Our aim was to investigate serum lipids' association with stage of liver fibrosis, steatosis and genotypes in patients with CHC...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28883845/the-impact-of-hyperglycemia-and-hyperlipidemia-on-plasma-p-selectin-and-platelet-markers-after-ischemic-stroke
#4
Malgorzata Pawelczyk, Beata Kaczorowska, Zbigniew Baj
INTRODUCTION: Platelet activation plays a key role in the pathogenesis of ischemic cerebrovascular diseases. Thus, it is very important to identify novel pharmacological targets for platelet inhibition to improve ischemic stroke treatment. The aim of the study was to assess the relationship between metabolic disorders and platelet activity markers in patients with acute ischemic stroke. MATERIAL AND METHODS: Ninety-four patients with acute ischemic stroke were divided into four groups with: normolipidemia and normoglycemia (NL/NG), n = 25; normolipidemia and hyperglycemia (NL/HG), n = 21; hyperlipidemia and normoglycemia (HL/NG), n = 27; hyperlipidemia and hyperglycemia (NL/NG), n = 21...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28880487/oxidized-low-density-lipoprotein-ox-ldl-promotes-cardiac-differentiation-of-bone-marrow-mesenchymal-stem-cells-via-activating-erk1-2-signaling
#5
Fenxi Zhang, Congrui Wang, Juntang Lin, Xianwei Wang
BACKGROUND/AIMS: The differentiation efficiency of bone marrow mesenchymal stem cells (BM-MSCs) is low in vivo after transplantation. Therefore, it is necessary to look for effective reagents for enhancing cardiac differentiation of BM-MSCs. It has been reported that cardiac differentiation of stem cells depends on the activation of extracellular signal-regulated protein 1/2 (ERK1/2) signaling. Oxidized low-density lipoprotein (ox-LDL) is a potent reagent for ERK1/2 activation. This indicates that ox-LDL may be a potential reagent to stimulate cardiac differentiation of stem cells...
September 7, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28871890/association-between-periodontitis-with-blood-lipid-levels-in-korean-population
#6
Seyoung Lee, Aejung Im, Eunae Burm, Mina Ha
BACKGROUND: Hyperlipidemia is a known risk factor for cardiovascular diseases. A common biological mechanism between systemic diseases like cardiovascular diseases and periodontal diseases has been suggested. We aimed to examine the association between blood lipid profile and periodontitis. METHODS: The study included 6,905 Korean adults, aged ≥20 years. Individuals with incomplete data on blood lipid levels, those who lacked results of periodontitis examination by using the Community Periodontal Index system in the Fifth Korean National Health and Nutrition Examination Survey for 2010 and 2012, and those diagnosed with diabetes mellitus, hypertension and hyperlipidemia were excluded from the study...
September 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28870280/glucose-and-cholesterol-stabilization-in-patients-with-type-2-diabetes-mellitus-with-depressive-and-anxiety-symptoms-by-problem-solving-therapy-in-primary-care-centers-in-mexico-city
#7
Valerio Villamil-Salcedo, Blanca E Vargas-Terrez, Jorge Caraveo-Anduaga, Jorge González-Olvera, Adriana Díaz-Anzaldúa, José Cortés-Sotres, Magdalena Pérez-Ávila
Aim The aim of this study was to determine if the problem-solving therapy (PST) helps control metabolic variables in patients with type 2 diabetes mellitus (T2DM) who show depressive and anxiety symptoms. BACKGROUND: T2DM is a chronic-degenerative multifactorial disease. It is considered one of the main public health problems in the world, and it represents an important social and economic burden. It is frequently associated with major depression and anxiety disorders, which are related with high glycated hemoglobin (HbA1c) concentrations and poor metabolic control...
September 5, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28856165/effect-of-yoga-training-on-inflammatory-cytokines-and-c-reactive-protein-in-employees-of-small-scale-industries
#8
Sanjay Uddhav Shete, Anita Verma, Dattatraya Devarao Kulkarni, Ranjeet Singh Bhogal
OBJECTIVE: The present study intends to see the effect of yoga practices on lipid profile, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and high-sensitivity-C-reactive protein (hs-CRP) among apparently healthy adults exposed to occupational hazards. MATERIALS AND METHODS: In the present study, 48 participants aged 30-58 years (41.5 ± 5.2) who were exposed to occupational hazards were randomized into two groups, that is, experimental and wait-list control...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28827206/relationship-between-gonadal-function-and-cardiometabolic-risk-in-young-men-with-chronic-spinal-cord-injury
#9
Shannon D Sullivan, Mark S Nash, Eshetu Tefara, Emily Tinsley, Suzanne Groah
BACKGROUND: We reported previously that young men with chronic spinal cord injury (SCI) have a greater prevalence of testosterone deficiency compared with an age-matched, healthy control population. Young men with SCI also are at increased risk for developing cardiometabolic dysfunction after injury. It is unclear whether testosterone deficiency is associated with heightened cardiometabolic risk in men with SCI. OBJECTIVE: To investigate associations among levels of testosterone in young men with chronic SCI and surrogate markers of cardiometabolic risk...
August 18, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28826575/apolipoprotein-b-is-associated-with-carotid-atherosclerosis-progression-independent-of-individual-cholesterol-measures-in-a-9-year-prospective-study-of-multi-ethnic-study-of-atherosclerosis-participants
#10
Brian T Steffen, Weihua Guan, Alan T Remaley, James H Stein, Mathew C Tattersall, Joel Kaufman, Michael Y Tsai
BACKGROUND: High blood cholesterol contributes to atherosclerosis, yet reliance on the lipid panel alone may mischaracterize individuals with elevated lipoprotein particle numbers. OBJECTIVE: The aim of the article was to determine whether elevated lipoprotein or apolipoprotein measures are associated with carotid atherosclerosis and plaque progression independent of cardiovascular (CV) risk factors including standard lipids in a subcohort of 2228 Multi-Ethnic Study of Atherosclerosis participants...
September 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28791379/felodipine-inhibits-ox-ldl-induced-reactive-oxygen-species-production-and-inflammation-in-human-umbilical-vein-endothelial-cells
#11
Jie Qi, Jian-Bao Zheng, Wen-Ting Ai, Xiao-Wei Yao, Lei Liang, Gong Cheng, Xi-Ling Shou, Chao-Feng Sun
Oxidative stress and inflammation are involved in the pathogenesis of atherosclerosis. Calcium channel blockers (CCBs) inhibit the development of atherosclerosis, although the underlying molecular basis has not been completely elucidated. The present study was designed to investigate the effects of felodipine, a CCB, on inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs) and to examine the underlying mechanisms of action. Oxidized low‑density lipoprotein (ox‑LDL) was used to induce an inflammatory response in HUVECs...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28761130/lipodystrophy-and-obesity-are-associated-with-decreased-number-of-t-cells-with-regulatory-function-and-pro-inflammatory-macrophage-phenotype
#12
S Berger, G Ceccarini, G Scabia, I Barone, C Pelosini, F Ferrari, S Magno, A Dattilo, L Chiovato, P Vitti, F Santini, M Maffei
BACKGROUND/OBJECTIVES: In lipodystrophy (LD) adipose tissue function to store lipids is impaired, leading to metabolic syndrome, similar to that found in obesity. Emerging evidence links dysmetabolism with disorders of the immune system. Our aim is to investigate whether T-cell populations with regulatory function and monocyte-derived macrophages (MDMs) are affected by LD and obesity. SUBJECTS/METHODS: Blood was collected from 16 LD, 16 obese (OB, BMI>30 kg m(-2)) and 16 healthy normal-weight women (CNT)...
November 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28740627/correlation-between-severity-of-ultrasonographic-nonalcoholic-fatty-liver-disease-and-cardiometabolic-risk-among-filipino-wellness-patients
#13
Lucky R Cuenza, Tamara Louise J Razon, Juan Carlo Dayrit
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition which is known to be related to factors that predispose to the development of coronary artery disease as well as development of metabolic syndrome. The study aimed to determine the association between ultrasound-based grading of hepatic steatosis with metabolic profile and estimated cardiovascular risk using the Framingham Risk Score (FRS). Methods: This was a cross-sectional study on 100 Filipino patients without established cardiovascular disease who underwent a general wellness health evaluation...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28737953/metabolic-factors-and-oxidative-stress-in-osteoarthritis-a-case-control-study
#14
Kaspar Tootsi, Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer
Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 ± 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 ± 8 years) were enrolled in the study...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28728064/ldl-subfractions-are-associated-with-incident-cardiovascular-disease-in-the-malm%C3%A3-prevention-project-study
#15
Dov Shiffman, Judy Z Louie, Michael P Caulfield, Peter M Nilsson, James J Devlin, Olle Melander
BACKGROUND AND AIMS: After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lipids. METHODS: Using a case-cohort design, participants were randomly drawn from the Malmö Prevention Project (MPP), a population-based prospective study of 18,240 participants, and supplemented with additional incident CVD events (5764 participants, 1784 CVD events)...
July 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28725627/effect-of-yoga-training-on-lipid-metabolism-in-industrial-workers-with-reference-to-body-constitution-prakriti
#16
Suchitra Doddoli, Sanjay Shete, Dattatraya Kulkarni, Ranjit Bhogal
INTRODUCTION: The progressive increase in dyslipidemia and physical inactivity are considered to be major risk factors for the onset of non communicable diseases. Awareness of body constitution plays a vital role to regularise optimum health. The present study was planned to evaluate the effect of yoga practices on lipid metabolism with reference to specific body constitution (Prakriti). METHODS: A self-as-control study was conducted on 36 male healthy volunteers between age group of 30-58 years...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28692864/serum-il-10-il-17-and-il-23-levels-as-bioumoral-bridges-between-dyslipidemia-and-atopy
#17
S Manti, S Leonardi, I Panasiti, T Arrigo, C Salpietro, C Cuppari
BACKGROUND: Although several studies suggest a possible link between dyslipidemia and atopy, literature findings are still unclear. OBJECTIVE: The aim of the study was to investigate the relationship between dyslipidemia and atopy in a pediatric population affected by dyslipidemia or dyslipidemia/atopic predisposition. MATERIALS AND METHODS: Children with dyslipidemia, dyslipidemia and atopy as well as healthy children were recruited. Serum total IgE, IL-10, IL-17, and IL-23 levels as well as fasting lipid values (total cholesterol, LDL, HDL and triglycerides) were performed on all enrolled children...
July 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28656095/controlling-lipids-aids-in-the-prevention-of-type-2-diabetes-hypertension-and-cardiovascular-diseases
#18
Shivananda B Nayak, Stephanie B Mohammed, Akash S Nayak
BACKGROUND: Abnormal lipid profiles are a characteristic feature of persons with chronic conditions in which the diabetic populations are recognized as the dominant group, regardless of gender and ethnicity worldwide. This study was conducted to identify and evaluate the abnormalities of serum lipid profiles in both nondiabetic and diabetic persons. METHODS: This study was a case-control investigation conducted between 2013 and 2015. The study enrolled 266 patients from the North Central and South West Regional Health Authorities of Trinidad...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28646711/effect-of-memantine-on-c-reactive-protein-and-lipid-profiles-in-bipolar-disorder
#19
Hui Hua Chang, Po See Chen, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, San-Yuan Huang, Jau-Shyong Hong, Yen Kuang Yang, Ru-Band Lu
BACKGROUND: Balance in the immune system plays roles in bipolar disorder (BD) and its metabolic co-morbidities. Memantine is an NMDA receptor antagonist with anti-inflammatory effects. However, the effects of memantine adjunct treatment on metabolic status of BD are unclear. METHODS: During the 12 weeks period, a total of 191 BD patients were enrolled and split into valproate (VPA) + placebo and VPA + memantine (5mg/day) arms. The fasting plasma levels of high-sensitivity C-reactive protein (CRP) and metabolic indices were assessed...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627930/randomized-comparative-efficacy-and-safety-study-of-intermittent-simvastatin-versus-fenofibrate-in-hemodialysis
#20
Aya M Abdel Magid, Maggie M Abbassi, Essam Eldin M Iskander, Osama Mohamady, Samar F Farid
AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0...
June 19, 2017: Journal of Comparative Effectiveness Research
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