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https://www.readbyqxmd.com/read/28737953/metabolic-factors-and-oxidative-stress-in-osteoarthritis-a-case-control-study
#1
Kaspar Tootsi, Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer
Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 ± 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 ± 8 years) were enrolled in the study...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28728064/ldl-subfractions-are-associated-with-incident-cardiovascular-disease-in-the-malm%C3%A3-prevention-project-study
#2
Dov Shiffman, Judy Z Louie, Michael P Caulfield, Peter M Nilsson, James J Devlin, Olle Melander
BACKGROUND AND AIMS: After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lipids. METHODS: Using a case-cohort design, participants were randomly drawn from the Malmö Prevention Project (MPP), a population-based prospective study of 18,240 participants, and supplemented with additional incident CVD events (5764 participants, 1784 CVD events)...
July 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28725627/effect-of-yoga-training-on-lipid-metabolism-in-industrial-workers-with-reference-to-body-constitution-prakriti
#3
Suchitra Doddoli, Sanjay Shete, Dattatraya Kulkarni, Ranjit Bhogal
INTRODUCTION: The progressive increase in dyslipidemia and physical inactivity are considered to be major risk factors for the onset of non communicable diseases. Awareness of body constitution plays a vital role to regularise optimum health. The present study was planned to evaluate the effect of yoga practices on lipid metabolism with reference to specific body constitution (Prakriti). METHODS: A self-as-control study was conducted on 36 male healthy volunteers between age group of 30-58 years...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28692864/serum-il-10-il-17-and-il-23-levels-as-bioumoral-bridges-between-dyslipidemia-and-atopy
#4
S Manti, S Leonardi, I Panasiti, T Arrigo, C Salpietro, C Cuppari
BACKGROUND: Although several studies suggest a possible link between dyslipidemia and atopy, literature findings are still unclear. OBJECTIVE: The aim of the study was to investigate the relationship between dyslipidemia and atopy in a pediatric population affected by dyslipidemia or dyslipidemia/atopic predisposition. MATERIALS AND METHODS: Children with dyslipidemia, dyslipidemia and atopy as well as healthy children were recruited. Serum total IgE, IL-10, IL-17, and IL-23 levels as well as fasting lipid values (total cholesterol, LDL, HDL and triglycerides) were performed on all enrolled children...
July 7, 2017: Cytokine
https://www.readbyqxmd.com/read/28656095/controlling-lipids-aids-in-the-prevention-of-type-2-diabetes-hypertension-and-cardiovascular-diseases
#5
Shivananda B Nayak, Stephanie B Mohammed, Akash S Nayak
BACKGROUND: Abnormal lipid profiles are a characteristic feature of persons with chronic conditions in which the diabetic populations are recognized as the dominant group, regardless of gender and ethnicity worldwide. This study was conducted to identify and evaluate the abnormalities of serum lipid profiles in both nondiabetic and diabetic persons. METHODS: This study was a case-control investigation conducted between 2013 and 2015. The study enrolled 266 patients from the North Central and South West Regional Health Authorities of Trinidad...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28646711/effect-of-memantine-on-c-reactive-protein-and-lipid-profiles-in-bipolar-disorder
#6
Hui Hua Chang, Po See Chen, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, San-Yuan Huang, Jau-Shyong Hong, Yen Kuang Yang, Ru-Band Lu
BACKGROUND: Balance in the immune system plays roles in bipolar disorder (BD) and its metabolic co-morbidities. Memantine is an NMDA receptor antagonist with anti-inflammatory effects. However, the effects of memantine adjunct treatment on metabolic status of BD are unclear. METHODS: During the 12 weeks period, a total of 191 BD patients were enrolled and split into valproate (VPA) + placebo and VPA + memantine (5mg/day) arms. The fasting plasma levels of high-sensitivity C-reactive protein (CRP) and metabolic indices were assessed...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627930/randomized-comparative-efficacy-and-safety-study-of-intermittent-simvastatin-versus-fenofibrate-in-hemodialysis
#7
Aya M Abdel Magid, Maggie M Abbassi, Essam Eldin M Iskander, Osama Mohamady, Samar F Farid
AIM: Compare the safety and efficacy of intermittent fenofibrate versus simvastatin in chronic hemodialysis patients. PATIENTS & METHODS: Sixty patients received either fenofibrate 100 mg or simvastatin 20 mg after their dialysis session (parallel study). The safety and efficacy of drugs on lipid profile, oxidized low-density lipoprotein (Ox-LDL), glutathione peroxidase and C-reactive protein were compared before and after 16-week treatment. RESULTS: After treatment, significant increase in glutathione peroxidase, significant decrease in total cholesterol, triglycerides, low density lipoprotein (LDL) and ox-LDL (p < 0...
June 19, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28554697/orthostatic-hypertension-in-normotensive-type-2-diabetics-what-characteristics
#8
W N Nibouche-Hattab, N Lanasri, F Zeraoulia, A Chibane, A Biad
AIM OF THE STUDY: We aimed to determine the prevalence of orthostatic hypertension (OHT) in normotensive, newly diagnosed type 2 diabetics, to assess clinical, biological characteristics of those patients and evaluate the evolution of their blood pressure, after one year of follow-up. MATERIALS AND METHODS: It is an observational, prospective, cohort study, on 108 normotensive, newly diagnosed diabetics, 40 men and 68 women aged from 40 to 70 ans. OHT was defined as an increase of systolic blood pressure (SBP) ≥20mmHg and/or diastolic blood pressure (DBP) ≥10mmHg, after 1 and 2min of standing from supine position...
June 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28496550/efficacy-and-safety-of-sglt2-inhibitors-in-reducing-glycated-hemoglobin-and-weight-in-emirati-patients-with-type-2-diabetes
#9
Alaaeldin Bashier, Azza Abdulaziz Khalifa, Fauzia Rashid, Elamin Ibrahim Abdelgadir, Amina Adil Al Qaysi, Razan Ali, Ahmed Eltinay, Jalal Nafach, Fatima Alsayyah, Fatheya Alawadi
BACKGROUND: SGLT2 inhibitors are a new class of drugs that act by inhibiting glucose reabsorption in the proximal renal tubules. Many trials have demonstrated their effectiveness in reducing glycated hemoglobin (HbA1c) and weight, but they have never been examined in Arab or Emirati populations. METHODS: We assessed the efficacy of SGLT2 inhibitors in reducing HbA1c and weight in our population and specifically in an Emirati cohort. We also assessed the effect on fasting blood glucose, blood pressure, lipid profile, serum creatinine, and side effects...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28488685/effect-of-diets-rich-in-either-saturated-fat-or-n-6-polyunsaturated-fatty-acids-and-supplemented-with-long-chain-n-3-polyunsaturated-fatty-acids-on-plasma-lipoprotein-profiles
#10
C B Dias, N Amigo, L G Wood, X Correig, M L Garg
BACKGROUND/OBJECTIVES: Abnormalities in lipoprotein profiles (size, distribution and concentration) play an important role in the pathobiology of atherosclerosis and coronary artery disease. Dietary fat, among other factors, has been demonstrated to modulate lipoprotein profiles. We aimed to investigate if background dietary fat (saturated, SFA versus omega-6 polyunsaturated fatty acids, n-6PUFA) was a determinant of the effects of LCn-3PUFA supplementation on lipoprotein profiles. SUBJECTS/METHODS: A randomized controlled clinical intervention trial in a parallel design was conducted...
May 10, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28484502/improved-lipid-profile-associated-with-daily-consumption-of-tri-sura-phon-in-healthy-overweight-volunteers-an-open-label-randomized-controlled-trial
#11
Sirigoon Kuamsub, Pariyaphat Singthong, Wipawee Chanthasri, Nicharee Chobngam, Warissara Sangkaew, Sasithorn Hemdecho, Thammarat Kaewmanee, Sasitorn Chusri
Tri-Sura-Phon (TSP), a traditional Thai polyherbal formula renowned for its rejuvenating properties, is commonly used as a blood tonic. It comprises Cinnamomum bejolghota, Cinnamomum parthenoxylon, and Aquilaria crassna. The aim of this study is to evaluate the beneficial properties of TSP tea consumption on blood glucose regulation and serum lipid profiles of healthy overweight volunteers. This open-label, randomized controlled trial was conducted in 70 healthy overweight adults. Two groups of 35 subjects took a TSP infusion or a placebo (cornstarch) twice daily for 8 weeks...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28461157/cholesterol-delivery-to-the-adrenal-glands-estimated-by-adrenal-venous-sampling-an-in%C3%A2-vivo-model-to-determine-the-contribution-of-circulating-lipoproteins-to-steroidogenesis-in-humans
#12
Edward Buitenwerf, Robin P F Dullaart, Anneke C Muller Kobold, Thera P Links, Wim J Sluiter, Margery A Connelly, Michiel N Kerstens
BACKGROUND: Cholesterol, required for adrenal steroid hormone synthesis, is at least in part derived from circulating lipoproteins. The contribution of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to adrenal steroidogenesis in humans is unclear. OBJECTIVE: The aim of the study was to determine the extent to which HDL and LDL are taken up by the adrenal glands using samples obtained during adrenal venous sampling (AVS). METHODS: AVS was successfully performed in 23 patients with primary aldosteronism...
April 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28454530/dyslipidemia-and-reference-values-for-fasting-plasma-lipid-concentrations-in-danish-north-european-white-children-and-adolescents
#13
Tenna Ruest Haarmark Nielsen, Ulrik Lausten-Thomsen, Cilius Esmann Fonvig, Christine Bøjsøe, Lise Pedersen, Palle Skov Bratholm, Torben Hansen, Oluf Pedersen, Jens-Christian Holm
BACKGROUND: Dyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. Cut-off values for fasting plasma lipid concentrations are typically set at fixed levels throughout childhood. The objective of this cross-sectional study was to generate fasting plasma lipid references for a Danish/North-European White population-based cohort of children and adolescents, and investigate the prevalence of dyslipidemia in this cohort as well as in a cohort with overweight/obesity...
April 28, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28438163/enhanced-status-of-inflammation-and-endothelial-activation-in-subjects-with-familial-hypercholesterolaemia-and-their-related-unaffected-family-members-a-case-control-study
#14
Thuhairah Rahman, Nur Suhana Hamzan, Atiqah Mokhsin, Radzi Rahmat, Zubin Othman Ibrahim, Rafezah Razali, Malathi Thevarajah, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) leads to premature coronary artery diseases (CAD) which pathophysiologically can be measured by inflammation, endothelial activation and oxidative stress status. However, the status of these biomarkers among related unaffected relatives of FH cases and whether FH is an independent predictor of these biomarkers have not been well established. Thus, this study aims to (1) compare the biomarkers of inflammation, endothelial activation and oxidative stress between patients with FH, their related unaffected relatives (RUC) and normolipaemic subjects (NC) (2)determine whether FH is an independent predictor of these biomarkers...
April 24, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28301565/parallel-comparison-of-risk-factors-between-progression-of-organic-stenosis-in-the-coronary-arteries-and-onset-of-acute-coronary-syndrome-by-covariance-structure-analysis
#15
Kazuo Ogawa, Kosuke Minai, Makoto Kawai, Toshikazu Tanaka, Tomohisa Nagoshi, Takayuki Ogawa, Michihiro Yoshimura
BACKGROUND: It is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated. OBJECTIVES: We investigated the differences in risk factors between these conditions using a statistical procedure. METHODS: The study population consisted of 1,029 patients with ischemic heart disease (IHD)...
2017: PloS One
https://www.readbyqxmd.com/read/28285655/correlation-of-metabolic-syndrome-severity-with-cardiovascular-health-markers-in-adolescents
#16
Arthur M Lee, Matthew J Gurka, Mark D DeBoer
BACKGROUND AND OBJECTIVES: The presence of metabolic syndrome (MetS) in childhood is a significant risk factor for later cardiovascular disease (CVD). Recent data showed temporal decreases in a sex- and race/ethnicity-specific MetS severity z-score among U.S. adolescents. Our goal was to characterize the relationship of this MetS z-score with other CVD risk indicators and assess their temporal trends and lifestyle influences. METHODS: We analyzed 4837 participants aged 12-20years from the National Health and Nutrition Examination Survey by 2-year waves from 1999 to 2012...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28281730/cardiovascular-risk-reduction-in-sedentary-postmenopausal-women-during-organised-physical-activity
#17
Krzysztof Mazurek, Piotr Żmijewski, Ewa Kozdroń, Anna Fojt, Anna Czajkowska, Piotr Szczypiorski, Tomasz Mazurek
BACKGROUND: Cardiovascular (CV) diseases are a major cause of death in elderly women. Aerobic training improves component CV risk factors. Long-term, higher-intensity, group-based and home-based exercise training has been shown to improve exer-cise performance. However, it is not clear if short-term, group-based or home-based training with an educational programme permanently improves cardiometabolic parameters in elderly women. AIM: The aim of the study was to evaluate the effectiveness of organised physical activity programmes dedicated to elderly, sedentary women...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28279074/oxidized-derivatives-of-linoleic-acid-in-pediatric-metabolic-syndrome-is-their-pathogenic-role-modulated-by-the-genetic-background-and-the-gut-microbiota
#18
Domenico Tricò, Anna Di Sessa, Sonia Caprio, Naga Chalasani, Wanqing Liu, Tiebing Liang, Joerg Graf, Raimund I Herzog, Casey D Johnson, Giuseppina Rosaria Umano, Ariel E Feldstein, Nicola Santoro
We tested whether oxidized linoleic acid metabolites (OXLAM) are associated with pediatric metabolic syndrome (MetS) and a proatherogenic lipoprotein profile in 122 obese adolescents. Furthermore, we examined whether genetic and metagenomic factors can modulate plasma OXLAM concentrations by genotyping the fatty acid desaturase 1/2 (FADS) gene and by characterizing the gut microbiota. Subjects with MetS (n = 50) showed higher concentrations of 9- and 13-oxo-octadecadienoic acid (9- and 13-oxo-ODE) than subjects without MetS (n = 72)...
April 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28277344/use-of-hydroxychloroquine-is-associated-with-improved-lipid-profile-in-rheumatoid-arthritis-patients
#19
Jose Felix Restrepo, Inmaculada Del Rincon, Emily Molina, Daniel F Battafarano, Agustin Escalante
BACKGROUND/PURPOSE: We examined the association between hydroxychloroquine (HCQ) and plasma lipid and glucose levels in rheumatoid arthritis (RA) cohort. METHODS: This is a retrospective cohort analysis of 1261 RA patients comparing fasting lipid profiles and plasma glucose between patients who were and were not taking HCQ. We divided patients into 3 groups based on HCQ exposure during follow-up: those who had never taken HCQ, those who took it intermittently, and those who took it continuously...
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28271456/niclosamide-as-an-anti-obesity-drug-an-experimental-study
#20
Ali I Al-Gareeb, Khalid D Aljubory, Hayder M Alkuraishy
BACKGROUND: Niclosamide is a well-known anthelminthic drug that exert its effects at least in part through induction of mitochondrial uncoupling. The cycling of mitochondrial proton plays an essential role in regulation of basal metabolic rate, so modulation of mitochondrial uncoupling may be helpful approach to fight obesity. OBJECTIVE: To assess the anti-obesity effects of niclosamide on mice with induced obesity. MATERIALS AND METHODS: Thirty male Albino mice, 8-10 weeks old, were divided randomly and equally in to three groups; Group 1 fed with standard diet, whereas both Groups 2 and 3 were fed with high fat diet (HFD)...
March 7, 2017: Eating and Weight Disorders: EWD
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