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Nalini Bansal, Vivek Vij, Mukul Rastogi
Objective. The goal of this study was to determine the etiopathological association of various hepatic nodules identified during gross examination of liver explants specimen and the grossing aspects of these abnormal nodules especially those smaller than 1 cm in diameter. Our aim was to analyze whether there is any association of macroregenerative and dysplastic nodule with hepatocellular carcinoma. Materials and Methods. Fifty consecutive liver explants specimens were analyzed for the presence of any abnormal nodule (abnormal nodule defined as any nodule different in color, texture, and appearance from adjacent liver tissue)...
2016: International Journal of Hepatology
Kimberley D Bruce, Dawid Szczepankiewicz, Kiran K Sihota, Manoj Ravindraanandan, Hugh Thomas, Karen A Lillycrop, Graham C Burdge, Mark A Hanson, Christopher D Byrne, Felino R Cagampang
BACKGROUND: We have previously shown that high fat (HF) feeding during pregnancy primes the development of non-alcoholic steatohepatits (NASH) in the adult offspring. However, the underlying mechanisms are unclear. AIMS: Since the endogenous molecular clock can regulate hepatic lipid metabolism, we investigated whether exposure to a HF diet during development could alter hepatic clock gene expression and contribute to NASH onset in later life. METHODS: Female mice were fed either a control (C, 7%kcal fat) or HF (45%kcal fat) diet...
July 2016: Biochimica et Biophysica Acta
Matthew M Yeh, Yajuan Liu, Michael Torbenson
Association between the steatohepatitic hepatocellular carcinoma (SH-HCC) and metabolic syndrome has been suggested. Most SH-HCC morphology appears to result from a typical HCC that retains the ability to respond to the metabolic syndrome and develops features of steatohepatitis. We aim to ask if this is true for all SH-HCC cases, or does the SH-HCC morphology in some cases reflect genetic changes inherent to the HCC itself, as opposed to wide tissue response in liver to the metabolic syndrome. Twelve SH-HCC cases occurring in individuals without metabolic syndrome were identified and examined pathologically...
November 2015: Human Pathology
Sumiyo Ando, Junji Shibahara, Akimasa Hayashi, Masashi Fukayama
Hepatocellular carcinoma (HCC) with steatohepatitic features (steatohepatitic HCC, SH-HCC) is a histological subset of HCC, highly associated with metabolic disease and underlying steatohepatitis. Although it has distinct clinicopathologic characteristics, little is known about the immunophenotype or genetic characteristics of SH-HCC. We conducted an immunohistochemical analysis on a tissue microarray containing 197 HCCs (70 SH-HCCs and 127 conventional HCCs (C-HCCs)), focusing on proteins associated with genetic subtypes of HCC and those associated with non-alcoholic fatty liver disease (NAFLD) or NAFLD-associated HCC...
November 2015: Virchows Archiv: An International Journal of Pathology
Yan Zhang, Yan Cui, Xiao-Li Wang, Xiang Shang, Zhi-Gang Qi, Jie Xue, Xi Zhao, Min Deng, Mei-Lin Xie
Peroxisome proliferator-activated receptor (PPAR) α/γ may control lipid metabolism and inflammatory response by regulating the downstream target genes, and play a crucial role in the process of non-alcoholic steatohepatitis (NASH) formation, but the difference and interaction between PPARα and PPARγ are poorly understood. The rat model with NASH was established by orally feeding high-fat and high-sucrose emulsion for 6weeks. The results shown that after the model rats were simultaneously treated with PPARα/γ agonists, the total cholesterol (TC), triglyceride (TG) and inflammatory cytokine levels in serum and hepatic tissue, the hepatic steatosis and inflammatory cellular infiltration were decreased, and were consistent with the results of hepatic lipogenic gene and nuclear factor (NF)-κB protein expressions...
September 2015: Cytokine
Poh Seng Tan, Shigeki Nakagawa, Nicolas Goossens, Anu Venkatesh, Tiangui Huang, Stephen C Ward, Xiaochen Sun, Won-Min Song, Anna Koh, Claudia Canasto-Chibuque, Manjeet Deshmukh, Venugopalan Nair, Milind Mahajan, Bin Zhang, Maria Isabel Fiel, Masahiro Kobayashi, Hiromitsu Kumada, Yujin Hoshida
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is the second most lethal cancer caused by lack of effective therapies. Although promising, HCC molecular classification, which enriches potential responders to specific therapies, has not yet been assessed in clinical trials of anti-HCC drugs. We aimed to overcome these challenges by developing clinicopathological surrogate indices of HCC molecular classification. METHODS: Hepatocellular carcinoma classification defined in our previous transcriptome meta-analysis (S1, S2 and S3 subclasses) was implemented in an FDA-approved diagnostic platform (Elements assay, NanoString)...
January 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Vlad Ratziu, Zachary Goodman, Arun Sanyal
Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have occurred in the therapeutic field. Thirty-five years after its formal description and after 15 years of intense scrutiny from researchers worldwide, there is still no approved drug for the treatment of non-alcoholic steatohepatits (NASH). In the meantime, progress in the understanding of pathophysiology, diagnosis - both invasive and non-invasive, epidemiology and even natural history have been substantial or, at times, spectacular...
April 2015: Journal of Hepatology
Yoshihisa Takahashi, Toshio Fukusato
Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is the most common chronic liver disease, and the prevalence is rapidly increasing worldwide. Nonalcoholic steatohepatitis (NASH), the severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma (HCC). Although noninvasive clinical scores and image-based diagnosis for NAFLD have improved, histopathological evaluation of biopsy specimens remains the gold standard for diagnosing NAFLD/NASH. Steatosis, lobular inflammation, and hepatocellular ballooning are all necessary components for the diagnosis of NASH; fibrosis is also typically observed...
November 14, 2014: World Journal of Gastroenterology: WJG
Steffi Hoppe, Christian von Loeffelholz, Johan F Lock, Stephanie Doecke, Bruno V Sinn, Anja Rieger, Maciej Malinowski, Andreas F H Pfeiffer, Peter Neuhaus, Martin Stockmann
BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery. METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score...
February 2015: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Arvind Ahuja, Archna Rastogi, Chaggan Bihari, Yashwant Patidar, Virendra Pamecha, Shiv K Sarin
No abstract text is available yet for this article.
January 2014: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
Hayato Nakagawa, Atsushi Umemura, Koji Taniguchi, Joan Font-Burgada, Debanjan Dhar, Hisanobu Ogata, Zhenyu Zhong, Mark A Valasek, Ekihiro Seki, Juan Hidalgo, Kazuhiko Koike, Randal J Kaufman, Michael Karin
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH), disorders that increase risk of hepatocellular carcinoma (HCC). To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis we fed wild-type (WT) and MUP-uPA mice, in which hepatocyte ER stress is induced by plasminogen activator expression, with high-fat diet. Although both strains were equally insulin resistant, the MUP-uPA mice exhibited more liver damage, more immune infiltration, and increased lipogenesis and, as a result, displayed classical NASH signs and developed typical steatohepatitic HCC...
September 8, 2014: Cancer Cell
Nalini Gupta, Archana Rastogi, Chhagan Bihari
We report a case of a 65 year old male who presented with complaints of pain right upper abdomen for past 3 months. He was a known diabetic and hypertensive. On evaluation he was found to have space occupying lesion in the right lobe of the liver. USG Guided FNC done showed a Hepatocellular Carcinoma with predominant steatosis. He underwent Right Hepetectomy for the same and Histopathological examination revealed a Steatohepatitic Hepatocellular Carcinoma with background liver showing minimal steatosis and no significant fibrosis...
June 2014: Indian Journal of Surgical Oncology
Junji Shibahara, Sumiyo Ando, Yoshihiro Sakamoto, Norihiro Kokudo, Masashi Fukayama
AIMS: The aim of this study was to investigate the clinicopathological significance of steatohepatitic features in hepatocellular carcinomas (HCCs) using a large-scale analysis. METHODS AND RESULTS: Retrospective clinicopathological analysis was performed on HCCs treated surgically at the University of Tokyo Hospital between 2005 and 2010. The diagnosis of HCC with steatohepatitic features (SH-HCC) was made if the tumour fulfilled four of the following five criteria: steatosis (>5% tumour cells), ballooning or Mallory-Denk body formation, interstitial fibrosis and inflammatory infiltrates...
June 2014: Histopathology
J Michael Estep, Zachary Goodman, Haveesh Sharma, Elana Younossi, Hazem Elarainy, Ancha Baranova, Zobair Younossi
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with visceral adiposity. The secretion of adipocytokines from white adipose tissue (WAT) promoting necroinflammation, and/or fibrosis may play important roles in the pathogenesis of non-alcoholic steatohepatits (NASH). In a previous study, reduced expression of a number of miRNA species in WAT concomitant with histological diagnosis of NASH was successfully demonstrated. In this study, we measure the expression of several predicted miRNA regulatory targets relevant to NAFLD and NASH including mTOR, FAS, IL20, SEMA4C, ADAMTS6 and IL13RA...
April 2015: Liver International: Official Journal of the International Association for the Study of the Liver
Srinivasan Periasamy, Dur-Zong Hsu, Po-Cheng Chang, Ming-Yie Liu
Sesame oil is a nutrient-rich antioxidant popular in alternative medicine. It contains sesamin, sesamol, and sesamolin, all of which contribute to its improved liver function in various animal model studies. However, its effect on nutritional fibrosing steatohepatitis is unclear. We investigated therapeutic sesame oil on matrix metalloproteinases-2, 9 (MMP-2, 9) in nutritional fibrosing steatohepatitic mice. C57BL/6 J mice were fed with methionine-choline deficient (MCD) diet for 35 days to induce fibrosing steatohepatitis...
March 2014: Journal of Nutritional Biochemistry
Srinivasan Periasamy, Se-Ping Chien, Po-Cheng Chang, Dur-Zong Hsu, Ming-Yie Liu
Nonalcoholic fatty liver disease, the most common chronic liver disorder worldwide, comprises conditions from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. NASH is associated with an increased risk of hepatocellular carcinoma. Sesame oil, a healthful food, increases resistance to oxidative stress, inflammation and protects against multiple organ injury in various animal models. We investigated the protective effect of sesame oil against nutritional steatohepatitis in mice. C57BL/6 J mice were fed with methionine-choline deficient (MCD) diet for 28 days to induce NASH...
February 2014: Journal of Nutritional Biochemistry
Sho-Ichi Yamagishi, Takanori Matsui
The metabolic syndrome is strongly associated with insulin resistance and visceral obesity and consists of a constellation of factors such as diabetes, hypertension, dyslipidemia and non-alcoholic steatohepatits, which could in concert increase the risk for cardiovascular diseases (CVD). CVD, including myocardial infarction and stroke, is one of the leading causes of morbidity and mortality in the developed countries. Atherothrombosis, characterized by atherosclerotic plaque disruption and subsequent thrombus formation, contributes to the pathogenesis of CVD...
2014: Current Pharmaceutical Design
Deepali Jain, Nabeen C Nayak, Vinay Kumaran, Sanjiv Saigal
CONTEXT: The common risk factors for hepatocellular carcinoma (HCC) include persistent viral infection with either hepatitis B or C virus, alcohol abuse, hemochromatosis, and metabolic syndrome. Steatohepatitic (SH) HCC has been recently recognized as a special morphologic variant of HCC associated with metabolic risk factors. OBJECTIVE: To assess the SH pattern in HCC cases of various etiologies in Indian patients and to further correlate this morphology with the presence of metabolic risk factors...
July 2013: Archives of Pathology & Laboratory Medicine
Suvarthi Das, Ashutosh Kumar, Ratanesh Kumar Seth, Erik J Tokar, Maria B Kadiiska, Michael P Waalkes, Ronald P Mason, Saurabh Chatterjee
Today's developed world faces a major public health challenge in the rise in the obese population and the increased incidence in fatty liver disease. There is a strong association among diet induced obesity, fatty liver disease and development of nonalcoholic steatohepatitis but the environmental link to disease progression remains unclear. Here we demonstrate that in obesity, early steatohepatitic lesions induced by the water disinfection byproduct bromodichloromethane are mediated by increased oxidative stress and leptin which act in synchrony to potentiate disease progression...
June 15, 2013: Toxicology and Applied Pharmacology
Jacob Alexander, Michael Torbenson, Tsung-Teh Wu, Matthew M Yeh
BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a major complication of cirrhosis and has been increasing in incidence in recent years. Fatty liver disease is an increasingly common cause of chronic liver disease, and there have been several case reports of HCC in patients with non-cirrhotic fatty liver disease. However, there is limited data from systematic studies with histological confirmation of the presence of both the HCC and the non-cirrhotic fatty liver disease. METHODS: We studied the occurrence of fatty liver disease and the associated demographic, clinical, and pathological characteristics of a large cohort of patients with HCC in non-cirrhotic livers...
May 2013: Journal of Gastroenterology and Hepatology
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