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https://www.readbyqxmd.com/read/28404072/distinctive-features-of-hepatocellular-carcinoma-in-non-alcoholic-fatty-liver-disease
#1
REVIEW
Elisabetta Degasperi, Massimo Colombo
Hepatocellular carcinoma is the fifth most common cancer and the second leading cause of cancer-related death worldwide. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis have been identified as emergent risk factors for this primary liver cancer. Incidence of NAFLD is increasing as a consequence of the epidemic spread of metabolic syndrome, which can result in progressive liver disease, leading to cirrhosis and its complications. Most data about the prevalence and incidence of hepatocellular carcinoma in patients with NAFLD are from a few population and cohort studies; its incidence is increasing and it is likely to become a leading indication for liver transplantation, especially in industrialised countries...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28273155/tumor-stroma-with-senescence-associated-secretory-phenotype-in-steatohepatitic-hepatocellular-carcinoma
#2
Jee San Lee, Jeong Eun Yoo, Haeryoung Kim, Hyungjin Rhee, Myoung Ju Koh, Ji Hae Nahm, Jin Sub Choi, Kee-Ho Lee, Young Nyun Park
Senescence secretome was recently reported to promote liver cancer in an obese mouse model. Steatohepatitic hepatocellular carcinoma (SH-HCC), a new variant of HCC, has been found in metabolic syndrome patients, and pericellular fibrosis, a characteristic feature of SH-HCC, suggests that alteration of the tumor stroma might play an important role in SH-HCC development. Clinicopathological characteristics and tumor stroma showing senescence and senescence-associated secretory phenotype (SASP) were investigated in 21 SH-HCCs and 34 conventional HCCs (C-HCCs)...
2017: PloS One
https://www.readbyqxmd.com/read/28236037/ppar%C3%AE-%C3%AE-antagonists-reverse-the-ameliorative-effects-of-osthole-on-hepatic-lipid-metabolism-and-inflammatory-response-in-steatohepatitic-rats
#3
Xi Zhao, Feng Wang, Ruijun Zhou, Zengyan Zhu, Meilin Xie
Our previous studies have indicated that osthole may ameliorate the hepatic lipid metabolism and inflammatory response in nonalcoholic steatohepatitic rats, but the underlying mechanisms remain unclear. This study aimed to determine whether the effects of osthole were mediated by the activation of hepatic peroxisome proliferator-activated receptor α/γ (PPARα/γ). A rat model with steatohepatitis was induced by orally feeding high-fat and high-sucrose emulsion for 6 weeks. These experimental rats were then treated with osthole (20 mg/kg), PPARα antagonist MK886 (1 mg/kg) plus osthole (20 mg/kg), PPARγ antagonist GW9662 (1 mg/kg) plus osthole (20 mg/kg) and MK886 (1 mg/kg) plus GW9662 (1 mg/kg) plus osthole (20 mg/kg) for 4 weeks...
February 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28143798/diagnostic-histopathology-of-hepatocellular-carcinoma-a-case-based-review
#4
Rashmi M Agni
Hepatocellular carcinoma (HCC) is the most common primary hepatic malignant neoplasm in adults. Clinically, it tends to present late, and its prognosis historically has been poor, due to limited treatment options at the more advanced stage. A multidisciplinary approach for surveillance and early diagnosis of hepatocellular carcinoma in high-risk populations, combined with advances in surgical and other forms of ablative or chemotherapy, has greatly improved outcomes for patients with this tumor. Liver biopsies for HCC are becoming rare, being performed only for lesions that are atypical on imaging, to avoid the risk of bleeding or of inadvertently seeding the needle tract with HCC...
December 21, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28079599/steatohepatitis-like-changes-in-focal-nodular-hyperplasia-a-finding-to-distinguish-from-steatohepatitic-variant-of-hepatocellular-carcinoma
#5
Kemal Deniz, Roger K Moreira, Matthew M Yeh, Linda D Ferrell
Steatohepatitis-like change has not been described in focal nodular hyperplasia (FNH). Steatohepatitis-like change in FNH may show overlapping features with steatohepatitic variant of hepatocellular carcinoma (HCC). This problem can be compounded if seen in FNH with widened cell plates or hepatocyte rosettes, other features that can also be seen in HCC. This study examined steatotic FNHs for the frequency of steatohepatitis-like change, especially in the setting of FNH with rosettes and/or widened cell plates...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27885796/hepatocellular-carcinomas-with-intracellular-hyaline-bodies-have-a-poor-prognosis
#6
Ariane Aigelsreiter, Jens Neumann, Martin Pichler, Judith Halasz, Kurt Zatloukal, Andrea Berghold, Philipp Douschan, Florian Rainer, Rudolf Stauber, Johannes Haybaeck, Helmut Denk, Carolin Lackner
BACKGROUND & AIMS: Mallory-Denk bodies (MDBs) and intracellular hyaline bodies (IHBs) are cytoplasmic inclusions found in a subset of hepatocellular carcinoma (HCC). MDBs are mainly composed of the intermediate filament proteins keratin (K) 8 and K18, the cellular stress- and adapter-protein sequestosome 1/p62 (p62) and ubiquitin, whereas IHBs consist of p62 and/or ubiquitin. Of note, cytoplasmic inclusions containing p62 can serve as markers of suppressed autophagy, which in turn has been associated with poor prognosis...
April 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27418978/different-nodules-identified-during-liver-explant-gross-examination-relevance-and-need-for-sectioning-experience-from-india
#7
Nalini Bansal, Vivek Vij, Mukul Rastogi
Objective. The goal of this study was to determine the etiopathological association of various hepatic nodules identified during gross examination of liver explants specimen and the grossing aspects of these abnormal nodules especially those smaller than 1 cm in diameter. Our aim was to analyze whether there is any association of macroregenerative and dysplastic nodule with hepatocellular carcinoma. Materials and Methods. Fifty consecutive liver explants specimens were analyzed for the presence of any abnormal nodule (abnormal nodule defined as any nodule different in color, texture, and appearance from adjacent liver tissue)...
2016: International Journal of Hepatology
https://www.readbyqxmd.com/read/27040510/altered-cellular-redox-status-sirtuin-abundance-and-clock-gene-expression-in-a-mouse-model-of-developmentally-primed-nash
#8
Kimberley D Bruce, Dawid Szczepankiewicz, Kiran K Sihota, Manoj Ravindraanandan, Hugh Thomas, Karen A Lillycrop, Graham C Burdge, Mark A Hanson, Christopher D Byrne, Felino R Cagampang
BACKGROUND: We have previously shown that high fat (HF) feeding during pregnancy primes the development of non-alcoholic steatohepatits (NASH) in the adult offspring. However, the underlying mechanisms are unclear. AIMS: Since the endogenous molecular clock can regulate hepatic lipid metabolism, we investigated whether exposure to a HF diet during development could alter hepatic clock gene expression and contribute to NASH onset in later life. METHODS: Female mice were fed either a control (C, 7%kcal fat) or HF (45%kcal fat) diet...
July 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26410018/steatohepatitic-variant-of-hepatocellular-carcinoma-in-the-absence-of-metabolic-syndrome-or-background-steatosis-a-clinical-pathological-and-genetic-study
#9
Matthew M Yeh, Yajuan Liu, Michael Torbenson
Association between the steatohepatitic hepatocellular carcinoma (SH-HCC) and metabolic syndrome has been suggested. Most SH-HCC morphology appears to result from a typical HCC that retains the ability to respond to the metabolic syndrome and develops features of steatohepatitis. We aim to ask if this is true for all SH-HCC cases, or does the SH-HCC morphology in some cases reflect genetic changes inherent to the HCC itself, as opposed to wide tissue response in liver to the metabolic syndrome. Twelve SH-HCC cases occurring in individuals without metabolic syndrome were identified and examined pathologically...
November 2015: Human Pathology
https://www.readbyqxmd.com/read/26311355/%C3%AE-catenin-alteration-is-rare-in-hepatocellular-carcinoma-with-steatohepatitic-features-immunohistochemical-and-mutational-study
#10
Sumiyo Ando, Junji Shibahara, Akimasa Hayashi, Masashi Fukayama
Hepatocellular carcinoma (HCC) with steatohepatitic features (steatohepatitic HCC, SH-HCC) is a histological subset of HCC, highly associated with metabolic disease and underlying steatohepatitis. Although it has distinct clinicopathologic characteristics, little is known about the immunophenotype or genetic characteristics of SH-HCC. We conducted an immunohistochemical analysis on a tissue microarray containing 197 HCCs (70 SH-HCCs and 127 conventional HCCs (C-HCCs)), focusing on proteins associated with genetic subtypes of HCC and those associated with non-alcoholic fatty liver disease (NAFLD) or NAFLD-associated HCC...
November 2015: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/26194065/ppar%C3%AE-%C3%AE-agonists-and-antagonists-differently-affect-hepatic-lipid-metabolism-oxidative-stress-and-inflammatory-cytokine-production-in-steatohepatitic-rats
#11
Yan Zhang, Yan Cui, Xiao-Li Wang, Xiang Shang, Zhi-Gang Qi, Jie Xue, Xi Zhao, Min Deng, Mei-Lin Xie
Peroxisome proliferator-activated receptor (PPAR) α/γ may control lipid metabolism and inflammatory response by regulating the downstream target genes, and play a crucial role in the process of non-alcoholic steatohepatitis (NASH) formation, but the difference and interaction between PPARα and PPARγ are poorly understood. The rat model with NASH was established by orally feeding high-fat and high-sucrose emulsion for 6weeks. The results shown that after the model rats were simultaneously treated with PPARα/γ agonists, the total cholesterol (TC), triglyceride (TG) and inflammatory cytokine levels in serum and hepatic tissue, the hepatic steatosis and inflammatory cellular infiltration were decreased, and were consistent with the results of hepatic lipogenic gene and nuclear factor (NF)-κB protein expressions...
September 2015: Cytokine
https://www.readbyqxmd.com/read/26058462/clinicopathological-indices-to-predict-hepatocellular-carcinoma-molecular-classification
#12
Poh Seng Tan, Shigeki Nakagawa, Nicolas Goossens, Anu Venkatesh, Tiangui Huang, Stephen C Ward, Xiaochen Sun, Won-Min Song, Anna Koh, Claudia Canasto-Chibuque, Manjeet Deshmukh, Venugopalan Nair, Milind Mahajan, Bin Zhang, Maria Isabel Fiel, Masahiro Kobayashi, Hiromitsu Kumada, Yujin Hoshida
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is the second most lethal cancer caused by lack of effective therapies. Although promising, HCC molecular classification, which enriches potential responders to specific therapies, has not yet been assessed in clinical trials of anti-HCC drugs. We aimed to overcome these challenges by developing clinicopathological surrogate indices of HCC molecular classification. METHODS: Hepatocellular carcinoma classification defined in our previous transcriptome meta-analysis (S1, S2 and S3 subclasses) was implemented in an FDA-approved diagnostic platform (Elements assay, NanoString)...
January 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/25920092/current-efforts-and-trends-in-the-treatment-of-nash
#13
REVIEW
Vlad Ratziu, Zachary Goodman, Arun Sanyal
Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have occurred in the therapeutic field. Thirty-five years after its formal description and after 15 years of intense scrutiny from researchers worldwide, there is still no approved drug for the treatment of non-alcoholic steatohepatits (NASH). In the meantime, progress in the understanding of pathophysiology, diagnosis - both invasive and non-invasive, epidemiology and even natural history have been substantial or, at times, spectacular...
April 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25400438/histopathology-of-nonalcoholic-fatty-liver-disease-nonalcoholic-steatohepatitis
#14
REVIEW
Yoshihisa Takahashi, Toshio Fukusato
Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is the most common chronic liver disease, and the prevalence is rapidly increasing worldwide. Nonalcoholic steatohepatitis (NASH), the severe form of NAFLD, can progress to liver cirrhosis and hepatocellular carcinoma (HCC). Although noninvasive clinical scores and image-based diagnosis for NAFLD have improved, histopathological evaluation of biopsy specimens remains the gold standard for diagnosing NAFLD/NASH. Steatosis, lobular inflammation, and hepatocellular ballooning are all necessary components for the diagnosis of NASH; fibrosis is also typically observed...
November 14, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25394215/nonalcoholic-steatohepatits-and-liver-steatosis-modify-partial-hepatectomy-recovery
#15
Steffi Hoppe, Christian von Loeffelholz, Johan F Lock, Stephanie Doecke, Bruno V Sinn, Anja Rieger, Maciej Malinowski, Andreas F H Pfeiffer, Peter Neuhaus, Martin Stockmann
BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery. METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score...
February 2015: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/25276908/steatohepatitic-variant-hepatocellular-carcinoma-a-case-report-of-new-histological-variant
#16
Arvind Ahuja, Archna Rastogi, Chaggan Bihari, Yashwant Patidar, Virendra Pamecha, Shiv K Sarin
No abstract text is available yet for this article.
January 2014: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
https://www.readbyqxmd.com/read/25132496/er-stress-cooperates-with-hypernutrition-to-trigger-tnf-dependent-spontaneous-hcc-development
#17
Hayato Nakagawa, Atsushi Umemura, Koji Taniguchi, Joan Font-Burgada, Debanjan Dhar, Hisanobu Ogata, Zhenyu Zhong, Mark A Valasek, Ekihiro Seki, Juan Hidalgo, Kazuhiko Koike, Randal J Kaufman, Michael Karin
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH), disorders that increase risk of hepatocellular carcinoma (HCC). To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis we fed wild-type (WT) and MUP-uPA mice, in which hepatocyte ER stress is induced by plasminogen activator expression, with high-fat diet. Although both strains were equally insulin resistant, the MUP-uPA mice exhibited more liver damage, more immune infiltration, and increased lipogenesis and, as a result, displayed classical NASH signs and developed typical steatohepatitic HCC...
September 8, 2014: Cancer Cell
https://www.readbyqxmd.com/read/25114474/steatohepatitic-hepatocellular-carcinoma-a-case-report-with-literature-review
#18
Nalini Gupta, Archana Rastogi, Chhagan Bihari
We report a case of a 65 year old male who presented with complaints of pain right upper abdomen for past 3 months. He was a known diabetic and hypertensive. On evaluation he was found to have space occupying lesion in the right lobe of the liver. USG Guided FNC done showed a Hepatocellular Carcinoma with predominant steatosis. He underwent Right Hepetectomy for the same and Histopathological examination revealed a Steatohepatitic Hepatocellular Carcinoma with background liver showing minimal steatosis and no significant fibrosis...
June 2014: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24898917/hepatocellular-carcinoma-with-steatohepatitic-features-a-clinicopathological-study-of-japanese-patients
#19
Junji Shibahara, Sumiyo Ando, Yoshihiro Sakamoto, Norihiro Kokudo, Masashi Fukayama
AIMS: The aim of this study was to investigate the clinicopathological significance of steatohepatitic features in hepatocellular carcinomas (HCCs) using a large-scale analysis. METHODS AND RESULTS: Retrospective clinicopathological analysis was performed on HCCs treated surgically at the University of Tokyo Hospital between 2005 and 2010. The diagnosis of HCC with steatohepatitic features (SH-HCC) was made if the tumour fulfilled four of the following five criteria: steatosis (>5% tumour cells), ballooning or Mallory-Denk body formation, interstitial fibrosis and inflammatory infiltrates...
June 2014: Histopathology
https://www.readbyqxmd.com/read/24684403/adipocytokine-expression-associated-with-mirna-regulation-and-diagnosis-of-nash-in-obese-patients-with-nafld
#20
J Michael Estep, Zachary Goodman, Haveesh Sharma, Elana Younossi, Hazem Elarainy, Ancha Baranova, Zobair Younossi
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with visceral adiposity. The secretion of adipocytokines from white adipose tissue (WAT) promoting necroinflammation, and/or fibrosis may play important roles in the pathogenesis of non-alcoholic steatohepatits (NASH). In a previous study, reduced expression of a number of miRNA species in WAT concomitant with histological diagnosis of NASH was successfully demonstrated. In this study, we measure the expression of several predicted miRNA regulatory targets relevant to NAFLD and NASH including mTOR, FAS, IL20, SEMA4C, ADAMTS6 and IL13RA...
April 2015: Liver International: Official Journal of the International Association for the Study of the Liver
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