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Osteoblasts allograft

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https://www.readbyqxmd.com/read/29525944/giant-periosteal-aggressive-epithelioid-osteoblastoma-21-year-old-male-presents-case-in-the-midshaft-of-his-femur
#1
Laura Sonnylal, Joel R Peterson, Alexander P Decilveo, Ian T O'Connor, James C Wittig
We report a rare case of giant periosteal osteoblastoma in the femur of a 21-year-old male. The patient presented with a painful, firm, non-tender mass in his left thigh. The pain was worse at night and was temporarily relieved with NSAIDS. He had no fevers, night sweats, or weight loss. The patient underwent preoperative radiological studies including plain radiographs, MRI, bone scan, and CT scan. An open biopsy was subsequently performed that was consistent with an aggressive, epithelioid osteoblastoma. Pathology demonstrated a neoplasm characterized by cohesive sheets of epithelioid osteoblasts, mixed with areas of conventional osteoblastoma displaying prominent osteoblastic rimming of woven bone trabeculae in a fibrovascular stroma...
March 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29498222/novel-cellulose-hydroxyapatite-scaffolds-for-bone-tissue-regeneration-in-vitro-and-in-vivo-study
#2
Povilas Daugela, Mindaugas Pranskunas, Gintaras Juodzbalys, Jolanta Liesiene, Odeta Baniukaitiene, Américo Afonso, Pedro Sousa Gomes
Cellulose scaffolds containing nano- or micro-hydroxyapatite (nHA or μHA) were prepared by the regeneration of cellulose from its acetylated derivative and the mechanical immobilization of inorganic particles, followed by freeze-drying. Microtomographic (micro-computed tomography) evaluation revealed that both scaffolds presented a highly interconnected porous structure, with a mean pore diameter of 490 ± 94 and 540 ± 132 μm for cellulose/nHA and cellulose/μHA, respectively. In vitro and in vivo characterizations of the developed scaffolds were investigated...
May 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29355746/bone-remodelling-in-vitro-where-are-we-headed-a-review-on-the-current-understanding-of-physiological-bone-remodelling-and-inflammation-and-the-strategies-for-testing-biomaterials-in-vitro
#3
REVIEW
Nupur Kohli, Sonia Ho, Stuart J Brown, Prasad Sawadkar, Vaibhav Sharma, Martyn Snow, Elena García-Gareta
Bone remodelling is a dynamic process required for the maintenance of bone architecture in response to the changing mechanical needs. It is also a vital process during the repair of bone tissue following injury. Clinical intervention in terms of autografting or allografting is often required to heal bone injuries where physiological healing fails. The use of biomaterials as alternatives to autografts and allografts has spurred a significant research interest into further development of biomaterials for better clinical outcomes...
May 2018: Bone
https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#4
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29273252/supercritical-carbon-dioxide-sterilized-bone-allograft-in-the-treatment-of-tunnel-defects-in-2-stage-revision-anterior-cruciate-ligament-reconstruction-a-histologic-evaluation
#5
Gerrit J Van de Pol, Fiona Bonar, Lucy J Salmon, Justin P Roe, Leo A Pinczewski
PURPOSE: To examine the histologic properties of supercritical carbon dioxide (sCO2 )-sterilized bone allograft for tunnel grafting and determine in vivo graft quality, as well as graft incorporation and remodeling, in 2-stage revision anterior cruciate ligament (ACL) surgery. METHODS: Histologic evaluation was performed in 12 subjects undergoing 2-stage revision ACL reconstruction. In the first stage, the femoral and tibial tunnels were debrided, tunnel dimensions were measured, and tunnels were grafted with sCO2 -sterilized bone allograft...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29153382/a-pilot-study-alternative-biomaterials-in-critical-sized-bone-defect-treatment
#6
Magdalena Tarchala, Victor Engel, Jake Barralet, Edward J Harvey
BACKGROUND: Critical-sized bone defects are a significant challenge with limited effective reconstructive options. The Masquelet Technique (MT) offers a solution to help restore form and function. Although this technique has produced promising results; a clear mechanism has not been determined. Theories include that the induced membrane has osteogenic potential or the membrane acts as a physical barrier to prevent fibrous tissue ingrowth. We hypothesize the induced membrane acts primarily as a physical barrier and that a synthetic non-biological membrane will allow a comparable amount of bone volume in the defect site...
November 9, 2017: Injury
https://www.readbyqxmd.com/read/29095664/graphene-based-scaffolds-on-bone-tissue-engineering
#7
Nasrin Shadjou, Mohammad Hasanzadeh, Balal Khalilzadeh
Tissue engineering has been emerging as a valid approach to the current therapies for bone regeneration/substitution. Tissue-engineered bone constructs have the potential to alleviate the demand arising from the shortage of suitable autograft and allograft materials for augmenting bone healing. Scaffolds play a central role in tissue engineering research, they not only provide as structural support for specific cells but also provide as the templates to guide new tissue growth and construction. In this survey we describe application of graphene based nano-biomaterials for bone tissue engineering...
January 1, 2018: Bioengineered
https://www.readbyqxmd.com/read/29093738/comparative-effectiveness-of-bone-grafting-using-xenograft-freeze-dried-cortical-bovine-allograft-freeze-dried-cortical-new-zealand-white-rabbit-xenograft-hydroxyapatite-bovine-and-xenograft-demineralized-bone-matrix-bovine-in-bone-defect-of-femoral-diaphysis
#8
Ferdiansyah Mahyudin, Dwikora Novembri Utomo, Heri Suroto, Tri Wahyu Martanto, Mouli Edward, Imelda Lumban Gaol
Autogenous bone graft is gold standard in treating bone defects, but it might have difficulty in corporation and rejection reaction. This study is to compare the effectiveness among freeze-dried xenograft, freeze-dried allograft, hydroxyapatite xenograft, and demineralized bone matrix xenograft as bone graft to fill bone defect in femoral diaphysis of white rabbit. Thirty male New Zealand white rabbits were distributed into five groups. Bone defect was filled correspondingly with xenograft freeze-dried cortical bovine, allograft freeze-dried cortical New Zealand white rabbit, xenograft hydroxyapatite bovine, and xenograft demineralized bone matrix bovine...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28971515/serum-proteomic-assessment-of-the-progression-of-fracture-healing
#9
Amira I Hussein, Christian Mancini, Kyle E Lybrand, Margaret E Cooke, Heather E Matheny, Brenna L Hogue, Paul Tornetta, Louis C Gerstenfeld
A targeted proteomic analysis of murine serum over a 35-day course of fracture healing was carried out to determine if serum proteomic changes could be used to monitor the biological progression of fracture healing. Transverse, closed femoral fractures where generated and stabilized with intramedullary fixation. A single stranded DNA aptamer-based multiplexed proteomic approach was used to assay 1,310 proteins. The transcriptomic profiles for genes matching the 1,310 proteins were obtained by microarray analysis of callus mRNA...
October 2, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28914114/shining-dead-bone-cause-for-cautious-interpretation-of-18-f-naf-pet-scans
#10
Magnus Bernhardsson, Olof Sandberg, Marcus Ressner, Jacek Koziorowski, Jonas Malmquist, Per Aspenberg
Background and purpose - [18 F]Fluoride ([18 F]NaF) PET scan is frequently used for estimation of bone healing rate and extent in cases of bone allografting and fracture healing. Some authors claim that [18 F]NaF uptake is a measure of osteoblastic activity, calcium metabolism, or bone turnover. Based on the known affinity of fluoride to hydroxyapatite, we challenged this view. Methods - 10 male rats received crushed, frozen allogeneic cortical bone fragments in a pouch in the abdominal wall on the right side, and hydroxyapatite granules on left side...
February 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/28875562/a-new-composite-hydrogel-combining-the-biological-properties-of-collagen-with-the-mechanical-properties-of-a-supramolecular-scaffold-for-bone-tissue-engineering
#11
Mathieu Maisani, Sophia Ziane, Camille Ehret, Lucie Levesque, Robin Siadous, Jean-François Le Meins, Pascale Chevallier, Philippe Barthélémy, Hugo De Oliveira, Joëlle Amédée, Diego Mantovani, Olivier Chassande
Tissue engineering is a promising alternative to autografts, allografts, or biomaterials to address the treatment of severe and large bone lesions. Classically, tissue engineering products associate a scaffold and cells and are implanted or injected into the lesion. These cells must be embedded in an appropriate biocompatible scaffold, which offers a favourable environment for their survival and differentiation. Here, we designed a composite hydrogel composed of collagen I, an extracellular matrix protein widely used in several therapeutic applications, which we associated with a physical hydrogel generated from a synthetic small amphiphilic molecule...
March 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28634532/cellularizing-hydrogel-based-scaffolds-to-repair-bone-tissue-how-to-create-a-physiologically-relevant-micro-environment
#12
Mathieu Maisani, Daniele Pezzoli, Olivier Chassande, Diego Mantovani
Tissue engineering is a promising alternative to autografts or allografts for the regeneration of large bone defects. Cell-free biomaterials with different degrees of sophistication can be used for several therapeutic indications, to stimulate bone repair by the host tissue. However, when osteoprogenitors are not available in the damaged tissue, exogenous cells with an osteoblast differentiation potential must be provided. These cells should have the capacity to colonize the defect and to participate in the building of new bone tissue...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28605001/determination-of-structural-femoral-head-allograft-viability-and-integrity-with-a-novel-diagnostic-tool-spect-ct-a-preliminary-study
#13
Kasım Kilicarslan, Nadir Yalcin, Vedat Bicici, Elif Ozdemir, Izzet Bingol, Seyda Turkolmez
OBJECTIVE: To evaluate the viability and integrity of fresh frozen bulk femoral head allografts obtained from the institutional bone bank that were used to reconstruct severe acetabular defects and to validate the SPECT/CT method which gives both anatomical and functional data for this purpose. METHODS: We retrospectively reviewed 9 patients (6 female, 3 male; mean age 63.6 years). Preoperative and postoperative leg lengths, existence of the Trendelenburg sign, range of motion of the hip, visual analogue score (VAS), Harris Hip Score (HHS) and any complication were assesed at each follow-up...
November 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28018706/application-of-platelet-rich-plasma-with-stem-cells-in-bone-and-periodontal-tissue-engineering
#14
REVIEW
Gabriela Fernandes, Shuying Yang
Presently, there is a high paucity of bone grafts in the United States and worldwide. Regenerating bone is of prime concern due to the current demand of bone grafts and the increasing number of diseases causing bone loss. Autogenous bone is the present gold standard of bone regeneration. However, disadvantages like donor site morbidity and its decreased availability limit its use. Even allografts and synthetic grafting materials have their own limitations. As certain specific stem cells can be directed to differentiate into an osteoblastic lineage in the presence of growth factors (GFs), it makes stem cells the ideal agents for bone regeneration...
2016: Bone Research
https://www.readbyqxmd.com/read/27990431/spatiotemporal-changes-of-calcitonin-gene-related-peptide-innervation-in-spinal-fusion
#15
Xiao-Yi Zhou, Xi-Ming Xu, Sui-Yi Wu, Fei Wang, Yi-Lin Yang, Ming Li, Xian-Zhao Wei
Few studies have investigated the role calcitonin gene-related peptide (CGRP) plays in the process of spinal fusion. The aim of the present study is to observe the temporal and spatial changes of CGRP induced by experimental fusion surgery in rats and elucidate the role of CGRP in spinal fusion. Male Sprague-Dawley rats were used in the study and the specimens were collected on the 7th, 14th, 21st, and 28th day, respectively. Then, histological and immunohistochemical analysis were applied to evaluate the fusion mass and spatiotemporal changes of CGRP chronologically...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27934558/fibroblast-growth-factor-23-in-postrenal-transplant-an-often-forgotten-hormone
#16
REVIEW
Fateme Shamekhi Amiri, Mohammad Reza Khatami
Fibroblast growth factor 23 is likely to be the most important regulator of phosphate homeostasis, which mediates its functions through fibroblast growth factor receptors and the coreceptor Klotho. In addition to reducing expression of the sodium-phosphate cotransporters NPT2a and NPT2c in the proximal tubules, fibroblast growth factor 23 inhibits renal 1α-hydroxylase and stimulates 24-hydroxylase and appears to reduce parathyroid hormone secretion in short-term studies. Fibroblast growth factor 23 synthesis and secretion by osteocytes and osteoblasts are upregulated through 1,25-dihydroxyvitamin D3 and through an increased dietary phosphate intake...
December 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27809990/the-roles-of-immune-cells-in-bone-healing-what-we-know-do-not-know-and-future-perspectives
#17
REVIEW
Jehan J El-Jawhari, Elena Jones, Peter V Giannoudis
Key events occurring during the bone healing include well-orchestrated and complex interactions between immune cells, multipotential stromal cells (MSCs), osteoblasts and osteoclasts. Through three overlapping phases of this physiological process, innate and adaptive immune cells, cytokines and chemokines have a significant role to play. The aim of the escalating immune response is to achieve an osseous healing in the shortest time and with the least complications facilitating the restoration of function. The uninterrupted progression of these biological events in conjunction with a favourable mechanical environment (stable fracture fixation) remains the hallmark of successful fracture healing...
November 2016: Injury
https://www.readbyqxmd.com/read/27797908/hematopoietic-stem-cell-mobilization-is-necessary-but-not-sufficient-for-tolerance-in-islet-transplantation
#18
Blair T Stocks, Analise B Thomas, Sydney K Elizer, Yuantee Zhu, Andrew F Marshall, Christopher S Wilson, Daniel J Moore
Overcoming the immune response to establish durable immune tolerance in type 1 diabetes remains a substantial challenge. The ongoing effector immune response involves numerous immune cell types but is ultimately orchestrated and sustained by the hematopoietic stem cell (HSC) niche. We therefore hypothesized that tolerance induction also requires these pluripotent precursors. In this study, we determined that the tolerance-inducing agent anti-CD45RB induces HSC mobilization in nonautoimmune B6 mice but not in diabetes-prone NOD mice...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27787807/in-vitro-comparison-of-the-efficacy-of-tgf-%C3%AE-1-and-pdgf-bb-in-combination-with-freeze-dried-bone-allografts-for-induction-of-osteogenic-differentiation-in-mg-63-osteoblast-like-cells
#19
COMPARATIVE STUDY
Surena Vahabi, Maryam Torshabi, Azadeh Esmaeil Nejad
Predictable regeneration of alveolar bone defects has always been a challenge in implant dentistry. Bone allografts are widely used bone substitutes with controversial osteoinductive activity. This in vitro study aimed to assess the osteogenic potential of some commercially available freeze-dried bone allografts supplemented with human recombinant platelet-derived growth factor-BB and transforming growth factor beta-1. Cell viability, mineralization, and osteogenic gene expression of MG-63 osteoblast-like cells were compared among the allograft alone, allograft/platelet-derived growth factor-BB, allograft/transforming growth factor beta-1, and allograft/platelet-derived growth factor-BB/transforming growth factor beta-1 groups...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27771827/recombinant-human-bone-morphogenetic-protein-rhbmp-9-induces-osteoblast-differentiation-when-combined-with-demineralized-freeze-dried-bone-allografts-dfdbas-or-biphasic-calcium-phosphate-bcp
#20
Masako Fujioka-Kobayashi, Benoit Schaller, Yufeng Zhang, Umadevi Kandalam, Maria Hernandez, Richard J Miron
OBJECTIVES: Recently, recombinant human bone morphogenetic protein 9 (rhBMP9) has been characterized as one of the most osteogenic growth factors among the 15 human BMPs. The aim of the present study was to investigate the effects of rhBMP9 in comparison to the clinically utilized rhBMP2 on in vitro cell behavior when combined with two bone graft materials including demineralized freeze-dried bone allografts (DFDBAs) and biphasic calcium phosphate (BCP). MATERIALS AND METHODS: The absorption and release kinetics of rhBMPs from DFDBA and BCP were investigated by ELISA...
June 2017: Clinical Oral Investigations
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