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https://www.readbyqxmd.com/read/29054181/clinico-angiographic-profile-and-procedural-outcomes-in-patients-undergoing-percutaneous-coronary-interventions-the-srinagar-registry
#1
Jahangir Rashid Beig, Tariq R Shah, Imran Hafeez, Mohd Iqbal Dar, Hilal A Rather, Nisar A Tramboo, Ajaz A Lone, Fayaz A Rather
BACKGROUND: This study was aimed at exploring the clinical profile, angiographic characteristics and procedural outcomes in patients undergoing PCI at our institute. METHODS: This prospective observational study included all consecutive patients who underwent PCI at our hospital between January 2014 and December 2015. Data including clinico-demographic profile, angiographic details and lesion characteristics were recorded in all patients. Procedural details including devices and drugs used, procedure related complications, and in-hospital outcomes of these patients were analysed...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29052905/metabolic-changes-in-patients-with-prostate-cancer-during-androgen-deprivation-therapy
#2
REVIEW
Koji Mitsuzuka, Yoichi Arai
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture...
October 20, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29050979/comparison-of-3-risk-estimators-to-guide-initiation-of-statin-therapy-for-primary-prevention-of-cardiovascular-disease
#3
Sandra Ofori, Sotonye Dodiyi-Manuel, Maclean R Akpa
BACKGROUND: Among high-risk individuals, statins are beneficial for primary prevention of cardiovascular disease (CVD). In Nigeria, currently, there are no CVD prevention guidelines, so the use of CVD risk estimation to guide statin therapy is left to the discretion of the physician. OBJECTIVE: The objective of the study was to compare 3 CVD risk estimation tools in the evaluation of patients presenting to a tertiary hospital in Nigeria. METHODS: Cross-sectional study involving 295 patients with any CVD risk factors but not taking statins...
October 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050287/association-between-the-mvk-and-mmab-polymorphisms-and-serum-lipid-levels
#4
Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang, Wei-Xiong Lin
Maonan ethnic group is a relatively conservative and isolated minority in China. Little is known about the association of the mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) single nucleotide polymorphisms (SNPs) and serum lipid levels. This study aimed to determine the association between four SNPs in the MVK/MMAB and serum lipid levels. Genotyping of the rs3759387, rs877710, rs7134594 and rs9593 SNPs was performed in 1264 Maonan subjects and 1251 Han participants. Allele and genotype frequencies of the selected SNPs were different between the two populations (P < 0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050004/study-on-clinical-factors-involved-in-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#5
Yusuke Horiuchi, Junko Fujisaki, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. METHODS: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014...
October 19, 2017: Digestion
https://www.readbyqxmd.com/read/29049933/systemic-autoimmune-diseases-are-associated-with-an-increased-risk-of-bipolar-disorder-a-nationwide-population-based-cohort-study
#6
Ling-Yi Wang, Jen-Huai Chiang, Shih-Fen Chen, Yu-Chih Shen
BACKGROUND: Studies suggested autoimmunity plays a role in the etiology of bipolar disorder (BD). This study aimed to investigate the association between systemic autoimmune diseases (SADs) and the subsequent development of BD, and examine the potential risk factors for developing BD. METHODS: Patients with SADs were identified in the Taiwan National Health Insurance Program (NHIP). A comparison cohort was created by matching patients without SADs with age. The SADs cohort consisted of 65,498 while the comparison cohort consisted of 261,992 patients...
October 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29048932/cardio-ankle-vascular-index-value-in-dyslipidemia-patients-affected-by-cardiovascular-risk-factors
#7
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Increased arterial stiffness is an independent cardiovascular risk factor in smokers or patients with diabetes mellitus and hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness and atherosclerosis. One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). However, there was a little research about which influence factors such as: hypertension, diabetes mellitus, and smoking could contribute to the atherosclerosis in the subjects withDLP...
October 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29047248/association-between-sleep-duration-and-injury-from-falling-among-older-adults-a-cross-sectional-analysis-of-korean-community-health-survey-data
#8
Jin Won Noh, Kyoung Beom Kim, Ju Hyun Lee, Yejin Lee, Byeong Hui Lee, Young Dae Kwon
PURPOSE: While sleeping problems increase with advancing age, there are inherent differences in sleep between males and females. Previous studies have shown inconsistent results of the relationship between sleep duration and risk of injury from falling. While controlling various sociodemographic and health-related factors, national representative data were used in order to analyze the association between sleep duration and injury from falling among older adults. MATERIALS AND METHODS: The data were obtained from the Korean Community Health Survey of 2011...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046948/planned-secondary-wound-closure-at-the-circular-stapler-insertion-site-after-laparoscopic-gastric-bypass-reduces-postoperative-morbidity-costs-and-hospital-stay
#9
Diana Vetter, Dimitri Aristotle Raptis, Mira Giama, Hanna Hosa, Markus K Muller, Antonio Nocito, Marc Schiesser, Rudolf Moos, Marco Bueter
PURPOSE: The aims of the present study were to assess whether planned secondary wound closure at the insertion site of the circular stapler reduces wound infection rate and postoperative morbidity after laparoscopic Roux-en-Y gastric bypass (RYGB) and to identify independent predictive factors increasing the risk for wound infections after RYGB. METHODS: This paper is a retrospective single-center analysis of a prospectively collected database of 1400 patients undergoing RYGB surgery in circular technique between June 2000 and June 2016...
October 18, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29046729/long-term-feeding-of-high-fat-plus-high-fructose-diet-induces-isolated-impaired-glucose-tolerance-and-skeletal-muscle-insulin-resistance-in-miniature-pigs
#10
Meng-Chieh Hsu, Mu-En Wang, Yi-Fan Jiang, Hung-Chang Liu, Yi-Chen Chen, Chih-Hsien Chiu
BACKGROUND: During the prediabetic development, the changes in β-cell function and tissue-specific insulin resistance have been described. However, there are conflicting views in insulin secretory capacity between early clinical observation and recent proposed mathematical model. On the basis of digestive and metabolic similarities with humans, swine have great potential as an animal model to investigate the progressive mechanisms of prediabetes. The aim of this study was to investigate the insulin secretory response and tissue-specific insulin resistance in a dietary-induced prediabetic porcine model...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29046626/curcumin-activates-ampk-pathway-and-regulates-lipid-metabolism-in-rats-following-prolonged-clozapine-exposure
#11
Zhen Liu, Changmeng Cui, Pengfei Xu, Ruili Dang, Hualin Cai, Dehua Liao, Mengqi Yang, Qingyan Feng, Xin Yan, Pei Jiang
Clozapine (CLO) remains an ultimate option for patients with treatment resistant schizophrenia. However, the atypical antipsychotic is often associated with serious metabolic side effects, such as dyslipidemia. Hepatic sterol regulatory element-binding proteins (SREBPs) are central in the allosteric control of a variety of lipid biosynthetic pathways. There is emerging evidence that CLO can activate SREBP pathway and enhance downstream lipogenesis, whereas curcumin (CUR), a major active compound of Curcuma longa, contains hypolipidemic properties...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29045483/lipid-profile-cardiovascular-disease-and-mortality-in-a-mediterranean-high-risk-population-the-escarval-risk-study
#12
Domingo Orozco-Beltran, Vicente F Gil-Guillen, Josep Redon, Jose M Martin-Moreno, Vicente Pallares-Carratala, Jorge Navarro-Perez, Francisco Valls-Roca, Carlos Sanchis-Domenech, Antonio Fernandez-Gimenez, Ana Perez-Navarro, Vicente Bertomeu-Martinez, Vicente Bertomeu-Gonzalez, Alberto Cordero, Manuel Pascual de la Torre, Jose L Trillo, Concepcion Carratala-Munuera, Salvador Pita-Fernandez, Ruth Uso, Ramon Durazo-Arvizu, Richard Cooper, Gines Sanz, Jose M Castellano, Juan F Ascaso, Rafael Carmena, Maria Tellez-Plaza
INTRODUCTION: The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association between different components of the standard lipid profile with all-cause mortality and hospitalization due to cardiovascular events in a high-risk population. METHODS: This prospective registry included high risk adults over 30 years old free of cardiovascular disease (2008-2012)...
2017: PloS One
https://www.readbyqxmd.com/read/29044139/diabetes-in-iran-prospective-analysis-from-first-nationwide-diabetes-report-of-national-program-for-prevention-and-control-of-diabetes-nppcd-2016
#13
Alireza Esteghamati, Bagher Larijani, Mohammad Haji Aghajani, Fatemeh Ghaemi, Jamshid Kermanchi, Ali Shahrami, Mohammad Saadat, Ensieh Nasli Esfahani, Morsaleh Ganji, Sina Noshad, Elias Khajeh, Alireza Ghajar, Behnam Heidari, Mohsen Afarideh, Jeffrey I Mechanick, Faramarz Ismail-Beigi
We estimated proportions of different types of diabetes, comorbidities, treatment (the use of oral glucose-lowering agents and insulin), control (hyperglycemia, dyslipidemia and hypertension) and chronic microvascular and macrovascular complications among people with diabetes presenting to the tertiary-care academic diabetes outpatient clinics in Iran. This study is the prospective analysis of data (n = 30,202) from the registry of university-affiliated adult outpatient diabetes clinics in the country during 2015-2016...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044080/amalric-sign-an-augur-of-ophthalmic-artery-occlusion
#14
Prathibha Hande, Babi Sinha, Shivani Nayak, Srilakshmi Srinivasan, Jyothi Shetty
A 75-year-old man presented to us with sudden onset of profound vision loss in his right eye and was identified as suffering from an ophthalmic artery occlusion. Apart from the retinal whitening and box-carring of the retinal arteries, there were characteristic triangular patches of retinal whitening in the midperipheral temporal fundus indicating a previous lateral posterior choroidal artery occlusion. The patient was a chronic smoker and had dyslipidemia. The carotid Doppler study showed complete occlusion of the internal carotid artery...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29041913/detrimental-effects-of-specific-periodontopathic-bacterial-infection-on-tachyarrhythmia-compared-to-bradyarrhythmia
#15
Norio Aoyama, Jun-Ichi Suzuki, Naho Kobayashi, Tomoya Hanatani, Norihiko Ashigaki, Asuka Yoshida, Yuka Shiheido, Hiroki Sato, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Masato Minabe, Yuichi Izumi, Mitsuaki Isobe
BACKGROUND: Tachyarrhythmia (TA) and bradyarrhythmia (BA) are cardiac rhythm disorders that result in the decline of quality of life. While patients with periodontitis are at a high risk of cardiovascular disease (CVD), little causal information between TA and BA has been provided to date. To assess the relationship, periodontal bacterial infection in patients with TA or BA was evaluated. METHODS: The subjects were patients with TA (n = 98) or BA (n = 40) who attended Tokyo Medical and Dental University hospital...
October 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29040067/early-onset-severe-obesity-due-to-complete-deletion-of-the-leptin-gene-in-a-boy
#16
Elif Ozsu, Serdar Ceylaner, Huseyin Onay
BACKGROUND: Monogenic obesity results from single gene mutations. Extreme obesity starting at an early age, especially in infancy, which is associated with endocrinopathy and metabolic disturbances is key to the diagnosis of monogenic obesity. CASE PRESENTATION: A 6-month-old boy was admitted to our clinic with severe obesity and food craving. He was born with a birth weight of 3400 g to first-cousin parents. He started to gain weight at an abnormal rate at the age of 2 months...
October 17, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29038791/traditional-chinese-medicine-protects-against-cytokine-production-as-the-potential-immunosuppressive-agents-in-atherosclerosis
#17
REVIEW
Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu
Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29038350/male-apoe-3-leiden-cetp-mice-on-high-fat-high-cholesterol-diet-exhibit-a-biphasic-dyslipidemic-response-mimicking-the-changes-in-plasma-lipids-observed-through-life-in-men
#18
Yared Paalvast, Albert Gerding, Yanan Wang, Vincent W Bloks, Theo H van Dijk, Rick Havinga, Ko Willems van Dijk, Patrick C N Rensen, Barbara M Bakker, Jan Albert Kuivenhoven, Albert K Groen
Physiological adaptations resulting in the development of the metabolic syndrome in man occur over a time span of several decades. This combined with the prohibitive financial cost and ethical concerns to measure key metabolic parameters repeatedly in subjects for the major part of their life span makes that comprehensive longitudinal human data sets are virtually nonexistent. While experimental mice are often used, little is known whether this species is in fact an adequate model to better understand the mechanisms that drive the metabolic syndrome in man...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29037611/improvement-in-the-management-of-dyslipidemia-in-a-clinical-practice-population-at-very-high-cardiovascular-risk-the-colipar-project
#19
Juan Cosín-Sales, Rafael Gisbert-Criado, Alicia M Maceira, Francisco Buendía, Rafael Gómez Ribelles, Jorge Ruvira
No abstract text is available yet for this article.
October 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29037572/gender-related-differences-in-the-control-of-cardiovascular-risk-factors-in-primary-care-for-elderly-patients-with-type-2-diabetes-a-cohort-study
#20
Abdallah Al-Salameh, Sophie Bucher, Bernard Bauduceau, Linda Benattar-Zibi, Gilles Berrut, Philippe Bertin, Emmanuelle Corruble, Nicolas Danchin, Geneviève Derumeaux, Jean Doucet, Bruno Falissard, Françoise Forette, Olivier Hanon, Rissane Ourabah, Florence Pasquier, Michel Pinget, Virginie Ringa, Laurent Becquemont
OBJECTIVE: The aim of this study was to estimate the association between gender and control of diabetes and other cardiovascular risk factors in elderly patients with type 2 diabetes mellitus. METHODS: The sujets âgés cohort is an observational study whose main objective was to describe the real-life management of elderly patients with type 2 diabetes mellitus in France. Nine hundred eighty-three patients with diabetes (517 men and 466 women) were recruited by 213 general practitioners and were followed up prospectively every 6 months for 3 years...
October 13, 2017: Canadian Journal of Diabetes
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