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https://www.readbyqxmd.com/read/29239150/gender-differences-in-septic-intensive-care-unit-patients
#1
Francesco Campanelli, Giovanni Landoni, Luca Cabrini, Alberto Zangrillo
BACKGROUND: The world population is mostly male at birth, although there is a shift in predominance over 55 years of age with more females than males. Male gender was recently hypothesized to be a risk factor for sepsis and septic shock; the reasons and the consequences of this odd discrepancy are yet a matter of debate. We investigated the percentage of males and females in a large number of trials performed on septic adult patients admitted to Intensive Care Units. METHODS: We analysed all the multicentre randomized controlled trials ever published in peer-reviewed Journals reporting a significant effect on mortality in intensive care unit septic adult patients; furthermore, we retrieved all the manuscripts dealing with sepsis or septic shock patients published in the last 3 years in the three medical Journals with the highest impact factor...
December 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29236642/noninvasive-cardiac-radiation-for-ablation-of-ventricular-tachycardia
#2
Phillip S Cuculich, Matthew R Schill, Rojano Kashani, Sasa Mutic, Adam Lang, Daniel Cooper, Mitchell Faddis, Marye Gleva, Amit Noheria, Timothy W Smith, Dennis Hallahan, Yoram Rudy, Clifford G Robinson
BACKGROUND: Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, noninvasive cardiac radioablation for ventricular tachycardia. METHODS: We targeted arrhythmogenic scar regions by combining anatomical imaging with noninvasive electrocardiographic imaging during ventricular tachycardia that was induced by means of an implantable cardioverter-defibrillator (ICD)...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236639/a-bivalent-meningococcal-b-vaccine-in-adolescents-and-young-adults
#3
Lars Ostergaard, Timo Vesikari, Judith Absalon, Johannes Beeslaar, Brian J Ward, Shelly Senders, Joseph J Eiden, Kathrin U Jansen, Annaliesa S Anderson, Laura J York, Thomas R Jones, Shannon L Harris, Robert O'Neill, David Radley, Roger Maansson, Jean-Louis Prégaldien, John Ginis, Nina B Staerke, John L Perez
BACKGROUND: MenB-FHbp is a licensed meningococcal B vaccine targeting factor H-binding protein. Two phase 3 studies assessed the safety of the vaccine and its immunogenicity against diverse strains of group B meningococcus. METHODS: We randomly assigned 3596 adolescents (10 to 18 years of age) to receive MenB-FHbp or hepatitis A virus vaccine and saline and assigned 3304 young adults (18 to 25 years of age) to receive MenB-FHbp or saline at baseline, 2 months, and 6 months...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236632/noninvasive-ablation-of-ventricular-tachycardia
#4
EDITORIAL
Roy M John, William G Stevenson
New England Journal of Medicine, Volume 377, Issue 24, Page 2388-2390, December 2017.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236630/kidney-diseases-associated-with-human-immunodeficiency-virus-infection
#5
Scott D Cohen, Jeffrey B Kopp, Paul L Kimmel
New England Journal of Medicine, Volume 377, Issue 24, Page 2363-2374, December 2017.
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29228640/comparison-of-primary-endpoints-between-publications-registries-and-protocols-of-phase-iii-cancer-clinical-trials
#6
Fei Liang, Xinmei Guo, Sheng Zhang, Hongxi Xue, Qiang Chen, Xichun Hu
Background: Decisions by leading journals to require trial registration and to make protocols of phase III randomized clinical trials (RCTs) publicly accessible were landmark events in clinical trial reporting. Materials and Methods: We identified phase III cancer RCTs published between 2013 and 2015 in New England Journal of Medicine (NEJM), The Lancet, The lancet Oncology, JAMA and Journal of Clinical Oncology (JCO). Results: We identified 345 reports of phase III RCTs of which 217 (62...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221458/a-cohort-examination-to-establish-reporting-of-the-remit-and-function-of-trial-steering-committees-in-randomised-controlled-trials
#7
Elizabeth J Conroy, Barbara Arch, Nicola L Harman, J Athene Lane, Steff C Lewis, John Norrie, Matthew R Sydes, Carrol Gamble
BACKGROUND: The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Steering Committee (TSC). Despite the executive role of the TSC, the CONSORT Statement does not explicitly require reporting of TSC activity, although is included as an example of good reporting. A lack of guidance on TSC reporting can impact transparency of trial oversight, ultimately leading to a misunderstanding regarding role and, subsequently, further variation in practice...
December 8, 2017: Trials
https://www.readbyqxmd.com/read/29170309/12%C3%A2-a-multi-centre-randomised-feasibility-study-evaluating-the-impact-of-a-prognostic-model-for-management-of-blunt-chest-wall-trauma-patients-stumbl-trial
#8
Ceri Battle, Hayley Hutchings, Zoe Abbott, Claire O'neill, Sam Groves, Alan Watkins, Fiona Lecky, Sally Jones, James Gagg, Rick Body, Phillip Evans
INTRODUCTION: A new prognostic model has been developed and externally validated, the aim of which is to assist in the management of the blunt chest wall trauma patient in the Emergency Department (ED). A definitive randomised controlled trial (impact trial), is required to assess the clinical and cost effectiveness of the new model, before it can be accepted in clinical practice. The purpose of this trial is to assess the feasibility and acceptability of such a definitive trial and inform its design...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29161267/sugar-industry-sponsorship-of-germ-free-rodent-studies-linking-sucrose-to-hyperlipidemia-and-cancer-an-historical-analysis-of-internal-documents
#9
Cristin E Kearns, Dorie Apollonio, Stanton A Glantz
In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr. W...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29149153/analysis-of-reporting-bias-in-vertebral-augmentation
#10
Douglas P Beall, Sean M Tutton, Kieran Murphy, Wayne Olan, Christopher Warner, Jack B Test
Osteoporotic vertebral compression fractures (OVCFs) are a significant cause of morbidity and mortality in the United States and worldwide, with estimates of 750,000 to 1.5 million occurring annually. As the elderly population continues to increase, the incidence of OVCFs will continue to rise, as will the morbidity and mortality associated with this condition. Vertebral augmentation (VA) was almost universally accepted as the appropriate treatment modality prior to 2 sham trials published in 2009 by the New England Journal of Medicine (NEJM)...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29101129/dissemination-of-2014-dual-antiplatelet-therapy-dapt-trial-results-a-systematic-review-of-scholarly-and-media-attention-over-7-months
#11
Melissa K Sharp, Romana Haneef, Philippe Ravaud, Isabelle Boutron
OBJECTIVE: To explore how the results from the 2014 dual antiplatelet therapy (DAPT) trial were disseminated to the scientific community and online media. DESIGN: A a systematic review of scholarly and public attention surrounding the DAPT study. SETTINGS: Data were collected from the ISI Web of Knowledge, Google Scholar, PubMed Commons, EurekAlert, the DAPT study website (www.daptstudy.org) and the New England Journal of Medicine website (for scholarly attention) and Altmetric Explorer, Snap Bird, YouTube (for public attention) citing DAPT study results appearing from 16 November 2014 to 10 June 2015...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29058806/an-epidemic-of-multiple-sclerosis-and-falling-infection-rates-reflecting-on-comparisons-made-and-the-rising-ms-incidence-in-bach-s-nejm-2002-figure
#12
Helen Tremlett, Robyn Lucas
Myths are common in science and research. Findings from a publication in a high impact, influential journal, can be accepted as fact, with an assumption that the peer review process ensures study validity. Repeated presentation of graphical representations or summary statements at scientific meetings and through citation in publications can cement the findings such that they guide 'understanding' of science and future research directions. Such may be the case with the multiple sclerosis (MS) related epidemiology presented within a wider review article published in 2002 in the New England Journal of Medicine (NEJM)...
October 23, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28993088/hip-and-knee-arthroplasty-orthopedic-literature-in-medical-journals-is-it-negatively-biased
#13
Ronald E Delanois, Chukwuweike U Gwam, Nicolas S Piuzzi, Morad Chughtai, Arthur L Malkani, Peter M Bonutti, Michael A Mont
BACKGROUND: Healthcare policy is often determined by well-designed studies most often published in high-impact medical journals. However, concern about the presence of publication bias against lower-extremity arthroplasty-related studies has called into question some of the validity of certain reports. There are only a few studies investigating the presence of the bias in high-impact medical journals against lower-extremity arthroplasty intervention, particularly in the Journal of American Medical Association (JAMA), New England Journal of Medicine (NEJM), and the Lancet...
September 19, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28954803/temporal-trends-in-use-of-composite-end-points-in-major-cardiovascular-randomized-clinical-trials-in-prominent-medical-journals
#14
Nigel S Tan, Sammy H Ali, Gerald Lebovic, Muhammad Mamdani, Andreas Laupacis, Andrew T Yan
BACKGROUND: Cardiovascular mortality has decreased over the past 5 decades, making it increasingly difficult to demonstrate significant benefits of new therapies in randomized clinical trials. We sought to determine whether the use of composite end points in major cardiovascular trials has changed over time and examine temporal trends in the clinical importance of individual components of these composite end points. METHODS AND RESULTS: Using a validated search strategy, we searched MEDLINE for randomized trials of therapies for primary or secondary cardiovascular prevention published in New England Journal of Medicine, The Lancet, and the Journal of the American Medical Association between 1986 and 2015...
October 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28954288/two-by-two-factorial-cancer-treatment-trials-is-sufficient-attention-being-paid-to-possible-interactions
#15
REVIEW
Boris Freidlin, Edward L Korn
Factorial 2 × 2 designs can be used to combine evaluation of two treatments in a single study. The standard analysis approach is based on a factorial analysis that evaluates each treatment by pooling data over the other treatment. This approach relies on the assumption that the effect of each treatment is not substantially affected by the other treatment. In many oncology settings, this no-interaction assumption cannot be adequately supported at the time the trial is designed. In this Commentary, we consider current practices for the design and analysis of factorial trials by performing a survey of factorial treatment trials published in the Journal of the National Cancer Institute, Journal of Clinical Oncology, and the New England Journal of Medicine (2007-2016)...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28901340/sticking-to-principles-and-anticipating-outcomes
#16
Tom Jefferson
Riassunto La pubblicazione di Unanticipated outcomes, la storia personale di Jerome P. Kassirer, ex direttore del New England Journal of Medicine, offre l'opportunità di considerare i principi etici dell'editoria biomedica e scientifica. Il conflitto di interessi, le dichiarazioni e la frode influenzano la credibilità della comunicazione medica, che poggia sulla robustezza e sulla trasparenza dei suoi processi. Non tutto è ancora perduto, ma dobbiamo essere guidati da forti principi morali e da un quadro coerente di valori...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28894852/top-100-cited-classic-articles-in-breast-cancer-research
#17
Erdal Uysal
OBJECTIVE: This study aimed to analyze 100 most cited articles in breast cancer research. MATERIALS AND METHODS: The data in this study were obtained by a search conducted on the Web of Science (WOS). In brief, the term "breast cancer" was typed in the search box of WOS basic research including all the years and the data. The analysis was carried out by compiling the top 100 cited articles in the shortlist as sorted by the journals, categories of the studies, the countries, the centers, the authors and the publication date...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28757260/comparison-between-publicly-accessible-publications-registries-and%C3%A2-protocols-of-phase-iii-trials-indicated-persistence-of-selective-outcome%C3%A2-reporting
#18
Sheng Zhang, Fei Liang, Wenfeng Li
OBJECTIVES: The decision to make protocols of phase III randomized controlled trials (RCTs) publicly accessible by leading journals was a landmark event in clinical trial reporting. Here, we compared primary outcomes defined in protocols with those in publications describing the trials and in trial registration. STUDY DESIGN AND SETTING: We identified phase III RCTs published between January 1, 2012, and June 30, 2015, in The New England Journal of Medicine, The Lancet, The Journal of the American Medical Association, and The BMJ with available protocols...
July 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28749016/trends-in-study-design-and-the-statistical-methods-employed-in-a-leading-general-medicine-journal
#19
M Gosho, Y Sato, K Nagashima, S Takahashi
WHAT IS KNOWN AND OBJECTIVE: Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature...
July 27, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28744998/science-or-popular-media-what-drives-breast-cancer-online-activity
#20
Ryan Sugrue, Erica Carthy, M E Kelly, Karl J Sweeney
Google Trends is reflective of international awareness. Since its launch in 2004, there have been several landmark publications, international awareness campaigns, and mainstream-media events that involve breast cancer. The aim of this study was to assess the impact of landmark academic publications vs mainstream-media announcements in driving online breast cancer activity via Google Trends. Ten breast cancer-related themes or landmark publications (five academic publications and five media-related events) were used to compare the impact of online search activity...
July 26, 2017: Breast Journal
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