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New England journal of medicine

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https://www.readbyqxmd.com/read/29924973/immune-checkpoint-blockade-across-the-cancer-care-continuum
#1
Beth A Helmink, Pierre-Olivier Gaudreau, Jennifer A Wargo
Four studies recently reported in the New England Journal of Medicine highlight advances in treatment with immune checkpoint blockade across the cancer care continuum. These findings demonstrate efficacy of these agents in the treatment of early and late-stage disease, as monotherapy or in combination, and in addition to-or in place of-standard front-line therapy.
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29902046/dissolving-the-dichotomy-in-health-and-healthcare
#2
Christine N Runyan
The New England Journal of Medicine Catalyst recently published an article entitled "It's Time to Treat Physical and Mental Health With Equal Intent" (Compton-Phillips & Mohta, 2018). The article describes a survey of the NEJM Catalyst Insights Council, a qualified group ( n =565) of U.S. executives, clinical leaders, and clinicians who are directly involved in health care delivery. Ninety nine percent of council members responded that mental health should not only be integrated into ambulatory medical care settings but also embrace a "shared concept of mutual responsibility" (p...
June 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29901504/vertebral-augmentation-is-superior-to-nonoperative-care-at-reducing-lower-back-pain-for-symptomatic-osteoporotic-compression-fractures-a-meta-analysis
#3
Sina Pourtaheri, William Luo, Christina Cui, Steven Garfin
STUDY DESIGN: This is a systematic review and meta-analysis. OBJECTIVE: This study's goal was to (i) assess the clinical outcomes with and without vertebral augmentation (VA) for osteoporotic vertebral compression fractures (VCFs) with versus without correlating signs and symptoms; and (ii) acute (symptoms <3 mo duration) and subacute VCFs (3-6 mo duration) versus chronic VCFs (>6 mo). SUMMARY OF BACKGROUND DATA: Previously, a randomized controlled trial in the New England Journal of Medicine concluded that vertebroplasty for osteoporotic VCFs provided no clinical benefit over sham surgery...
June 12, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29900177/reporting-data-analysis-methods-in-high-impact-respiratory-journals
#4
Pentti Nieminen, Tuula Toljamo, Hannu Vähänikkilä
Data analysis methods play an important role in respiratory research. We evaluated the application and complexity of data analytical methods in high-impact respiratory journals and compared the statistical reporting in these respiratory articles with reports published in other eminent medical journals. This study involved a total of 160 papers published in 2015 in the European Respiratory Journal, American Journal of Respiratory and Critical Care Medicine, Chest and Thorax , and 680 papers published between 2007-2015 in other medical journals including the Lancet and New England Journal of Medicine ...
April 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29847766/a-new-standard-of-care-for-advanced-lung-cancer
#5
EDITORIAL
Joan H Schiller
New England Journal of Medicine, Volume 378, Issue 22, Page 2135-2137, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847764/pemberton-s-sign-in-a-patient-with-a-goiter
#6
Yazan Abu-Shama, Thomas Cuny
New England Journal of Medicine, Volume 378, Issue 22, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847763/innovation-for-pandemics
#7
Bill Gates
Over recent decades, the world has seen incredible progress in reducing child mortality and tackling infectious diseases. Thanks to better vaccines and other interventions, child mortality has decreased by more than 50% since 1990. We are on the verge of eradicating polio. HIV is no longer a..
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847762/radial-artery-as-the-preferred-second-conduit-for-coronary-bypass
#8
EDITORIAL
Oz M Shapira
New England Journal of Medicine, Volume 378, Issue 22, Page 2134-2135, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847759/digital-rectal-examination-and-anoscopy
#9
Taufiek K Rajab, Liliana G Bordeianou, Arvind von Keudell, Hanna Rajab, Haiyang Zhou
New England Journal of Medicine, Volume 378, Issue 22, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847758/excluding-observation-stays-from-readmission-rates-what-quality-measures-are-missing
#10
Amber K Sabbatini, Brad Wright
For the past several years, health care reform efforts have focused on reducing preventable hospital readmissions. Most notably, in 2012, the Centers for Medicare and Medicaid Services introduced the Hospital Readmissions Reduction Program (HRRP), which penalizes hospitals that have..
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847757/multiplicity-considerations-in-clinical-trials
#11
REVIEW
Alex Dmitrienko, Ralph B D'Agostino
New England Journal of Medicine, Volume 378, Issue 22, Page 2115-2122, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847756/severe-vulvovaginal-varicosities-in-pregnancy
#12
Georgios C Pratilas, Konstantinos Dinas
New England Journal of Medicine, Volume 378, Issue 22, Page 2123-2123, May 2018.
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847754/case-17-2018-a-40-year-old-woman-with-leg-swelling-and-abdominal-distention-and-pain
#13
Charles A Morris, Midhir J Patel, Andrew Z Fenves, Ricard Masia
Presentation of Case. Dr. Molly E. Wolf (Medicine): A 40-year-old woman was evaluated at this hospital because of progressive edema of the legs, as well as abdominal distention and pain. The patient had been in good health until approximately 10 months before this evaluation, when episodes of pain..
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847753/beyond-legalization-dilemmas-physicians-confront-regarding-aid-in-dying
#14
Bernard Lo
"What do you think about physician aid in dying?" Because 18.2% of the U.S. population lives in jurisdictions where physician aid in dying (PAD) is now legal, physicians need to anticipate that patients may inquire about or request it. Two decades ago, when PAD was illegal throughout the United..
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29847752/preserving-access-for-people-with-disabilities
#15
Laura Rothstein
Title III of the Americans with Disabilities Act (ADA) prohibits discrimination against persons with disabilities in "places of public accommodation" — those that are generally open to the public, including such categories as schools, restaurants, and doctors’ offices. But in response to allegedly..
May 31, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29808332/the-100-most-cited-articles-in-parkinson-s-disease
#16
Jin-Hua Xue, Zhi-Ping Hu, Ping Lai, De-Qing Cai, Er-Sheng Wen
BACKGROUND: Parkinson's disease (PD), the second most common neurodegenerative disease, has serious clinical effects. Research on PD is increasing, but the quantity and quality of this research have not been reported. METHODS: To analyze the most-cited articles on PD and provide information about developments in this field, we searched for articles in the Web of Science for the keyword "Parkinson*" in the title. We selected the 100 most-cited articles and evaluated information including citation number, publication time, journal, impact factor, authors, original country, institution of corresponding author, and study type...
May 28, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29804611/editorial-commentary-defer-no-time-delays-have-dangerous-ends-henry-vi-shakespeare-delayed-anterior-cruciate-ligament-reconstruction-has-consequences
#17
EDITORIAL
Mark G Siegel
There continues to be controversy over the timing of anterior cruciate ligament (ACL) surgery. Early or delayed intervention after ACL injury is a topic that has not been settled. The issue is whether ACL tears should have surgery performed in an expedient manner. Or is delay an option with no repercussions to the health of the knee? My associates in nonsurgical specialties wave the New England Journal of Medicine to support their view that surgery is not needed. I routinely espouse the literature confirming that delay of surgery may cause future damage...
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29791831/the-lymph-node-and-the-metastasis
#18
Vivianne Tjan-Heijnen, Giuseppe Viale
New England Journal of Medicine, Volume 378, Issue 21, Page 2045-2046, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791830/learning-from-a-trial-stopped-by-a-data-and-safety-monitoring-board
#19
EDITORIAL
David Harrington, Jeffrey M Drazen
New England Journal of Medicine, Volume 378, Issue 21, Page 2031-2032, May 2018.
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29791829/burosumab-therapy-in-children-with-x-linked-hypophosphatemia
#20
RANDOMIZED CONTROLLED TRIAL
Thomas O Carpenter, Michael P Whyte, Erik A Imel, Annemieke M Boot, Wolfgang Högler, Agnès Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A Portale
BACKGROUND: X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities. We investigated burosumab, a monoclonal antibody that targets FGF-23, in patients with X-linked hypophosphatemia. METHODS: In an open-label, phase 2 trial, we randomly assigned 52 children with X-linked hypophosphatemia, in a 1:1 ratio, to receive subcutaneous burosumab either every 2 weeks or every 4 weeks; the dose was adjusted to achieve a serum phosphorus level at the low end of the normal range...
May 24, 2018: New England Journal of Medicine
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