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'Patient-centred imaging'

Marcus Söderberg
Today, computed tomography (CT) systems routinely use automatic exposure control (AEC), which modulates the tube current. However, for optimal use, there are several aspects of an AEC system that need to be considered. The purpose of this study was to provide an overview of the Siemens CARE Dose 4D AEC system, discuss practical tips and demonstrate potential pitfalls. Two adult anthropomorphic phantoms were examined using two different Siemens CT systems. When optimising the CT radiation dose and image quality, the projection angle of the localiser, patient centring, protocol selection, scanning direction and the use of protective devices requires special attention...
June 2016: Radiation Protection Dosimetry
A S Resseguier, M André, E A Orian Lazar, G Bommelaer, O Tournilhac, I Delèvaux, M Ruivard, M D'Incan, L Boyer, O Aumaître
PURPOSE: Portal cavernoma follows a chronic occlusion of the portal vein. The long-term consequences of portal cavernoma are not well known. The objective of this study was to report the aetiology of the portal cavernoma and its natural course after excluding liver diseases causes. METHODOLOGY: A single centre retrospective study based on the data collected from the radiology department of the Clermont-Ferrand hospital was conducted from 2000 to 2011. All the patients for whom an imagery found a portal cavernoma have been looked for excluding the patients having a liver disease whatever the aetiology and the Budd-Chiari syndrome...
June 2016: La Revue de Médecine Interne
Ron Wald, Marc B Goldstein, Jeffrey Perl, Mercedeh Kiaii, Darren Yuen, Rachel M Wald, Ziv Harel, Jordan J Weinstein, Baruch Jakubovic, Howard Leong-Poi, Anish Kirpalani, Jonathon Leipsic, Niki Dacouris, Myles Wolf, Andrew T Yan
BACKGROUND: In-centre nocturnal hemodialysis (INHD, 7-8 hours/session, 3 times/week) is an increasingly utilized form of dialysis intensification, though data on the cardiovascular benefits of this modality are limited. METHODS: In this prospective cohort study, we enrolled 67 prevalent conventional hemodialysis (CHD, 4 hours/session, 3 times/week) recipients at 2 medical centres in Canada, of whom 37 converted to INHD and 30 remained on CHD. The primary outcome was the change in left ventricular mass (LVM) after 1 year as assessed by cardiac magnetic resonance imaging...
March 2016: Canadian Journal of Cardiology
Ingo Eitel, Thomas Stiermaier, Karl P Rommel, Georg Fuernau, Marcus Sandri, Norman Mangner, Axel Linke, Sandra Erbs, Phillip Lurz, Enno Boudriot, Meinhard Mende, Steffen Desch, Gerhard Schuler, Holger Thiele
AIMS: Remote ischaemic conditioning (RIC) and postconditioning (PostC) are both potent activators of innate protection against ischaemia-reperfusion injury and have demonstrated cardioprotection in experimental and clinical ST-elevation myocardial infarction (STEMI) trials. However, their combined effects have not been studied in detail. The aim of this study was to evaluate if the co-application of intrahospital RIC and PostC has a more powerful effect on myocardial salvage compared with either PostC alone or control...
November 21, 2015: European Heart Journal
Jennifer S ten Kulve, Dick J Veltman, Liselotte van Bloemendaal, Frederik Barkhof, Carolyn F Deacon, Jens J Holst, Robert J Konrad, John H Sloan, Madeleine L Drent, Michaela Diamant, Richard G IJzerman
AIMS/HYPOTHESIS: The central nervous system (CNS) is a major player in the regulation of food intake. The gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have an important role in this regulation by relaying information about nutritional status to the CNS. We hypothesised that endogenous GLP-1 has effects on CNS reward and satiety circuits. METHODS: This was a randomised, crossover, placebo-controlled intervention study, performed in a university medical centre in the Netherlands...
December 2015: Diabetologia
Rohini Sharma, Kumar G Kallur, Jin S Ryu, Ramanathapuram V Parameswaran, Henrik Lindman, Norbert Avril, Fergus V Gleeson, Jong D Lee, Kyung-Han Lee, Michael J O'Doherty, Ashley M Groves, Matthew P Miller, Edward J Somer, Charles R Coombes, Eric O Aboagye
UNLABELLED: Integrins are upregulated on both tumor cells and associated vasculature, where they play an important role in angiogenesis and metastasis. Fluciclatide is an arginine-glycine-aspartic acid peptide with high affinity for αvβ3/αvβ5 integrin, which can be radiolabeled for PET imaging of angiogenesis. Thus, (18)F-fluciclatide is a potential biomarker of therapeutic response to antiangiogenic inhibitors. The aim of this study was to evaluate the reproducibility of (18)F-fluciclatide in multiple solid-tumor types...
December 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Anna N Vongerichten, Gustavo Sato dos Santos, Kirill Aristovich, James Avery, Andrew McEvoy, Matthew Walker, David S Holder
Epilepsy affects approximately 50 million people worldwide, and 20-30% of these cases are refractory to antiepileptic drugs. Many patients with intractable epilepsy can benefit from surgical resection of the tissue generating the seizures; however, difficulty in precisely localising seizure foci has limited the number of patients undergoing surgery as well as potentially lowered its effectiveness. Here we demonstrate a novel imaging method for monitoring rapid changes in cerebral tissue impedance occurring during interictal and ictal activity, and show that it can reveal the propagation of pathological activity in the cortex...
January 1, 2016: NeuroImage
Christiane Busch, Kiril Penov, Paulo A Amorim, Jens Garbade, Piroze Davierwala, Gerhard C Schuler, Ardawan J Rastan, Friedrich-Wilhelm Mohr
OBJECTIVES: Constrictive pericarditis (CP) is an uncommon disease with multiple causes and unclear clinical outcomes. To date, few publications have clearly defined risk factors of poor outcomes after surgery for CP. We performed a retrospective analysis of almost 100 patients undergoing surgical treatment for CP at a single institution in order to identify risk factors for perioperative and long-term mortality. METHODS: A total of 97 consecutive patients (67.0% male) undergoing surgery for CP at our institution from 1995 to 2012 were included in the study...
December 2015: European Journal of Cardio-thoracic Surgery
Mirko D'Onofrio, Riccardo De Robertis, Emilio Barbi, Enrico Martone, Erminia Manfrin, Stefano Gobbo, Gino Puntel, Franco Bonetti, Roberto Pozzi Mucelli
OBJECTIVES: To evaluate the diagnostic accuracy and complication rate of percutaneous ultrasound-guided fine-needle aspiration (US-FNA) of solid pancreatic neoplasms through the analysis of 10-year experiences of two centres. METHODS: Clinical, radiological and pathologic data of 2,024 patients with solid pancreatic masses who underwent US-FNAs were retrospectively evaluated. Indications for aspiration were: unresectable lesions before neo-adjuvant therapy; doubtful imaging findings; and suspicion of uncommon neoplasms with prognostic or therapeutic implications such as metastases or lymphoma...
June 2016: European Radiology
Sean C G Martin, Mario K C H Teo, Adam M H Young, Ian M Godber, Sachin S Mandalia, Edward J St George, Calum McGregor
INTRODUCTION: Acute severe headache is a common medical presentation, and a common area of diagnostic uncertainty. Subarachnoid haemorrhage (SAH) is the cause in a minority of patients and has a high rate of morbidity and mortality. Therefore, its conclusive diagnosis with computed tomography (CT) or lumbar puncture (LP) is paramount. With advancement in imaging technology, emerging evidence now suggests that LP is no longer required for a subset of patients as CT has 100% sensitivity in detecting SAH, when performed under specific conditions...
2015: British Journal of Neurosurgery
Ehsan Ghorani, Han Hsi Wong, Carole Hewitt, Joanna Calder, Pippa Corrie, Bristi Basu
OBJECTIVES: The combination of 5-fluorouracil (5-FU), irinotecan and oxaliplatin (FOLFIRINOX) is considered the first-line chemotherapy for fit patients with advanced pancreatic ductal adenocarcinoma (PDAC) but carries an unfavourable adverse event (AE) profile. We retrospectively evaluated the tolerability and efficacy of a modified FOLFIRINOX (mFOLFIRINOX) regimen: intravenous oxaliplatin 85 mg/m2, irinotecan 135 mg/m2, folinic acid 400 mg/m2 and 5-FU infusion 2,400 mg/m2 over 46 h, with routine subcutaneous filgrastim on a 14-day cycle...
2015: Oncology
A T Congalton, A M Oakley, M Rademaker, D Bramley, R C W Martin
BACKGROUND: A Virtual Lesion Clinic (VLC) using teledermatoscopy was established to improve efficiency of the melanoma referral pathway. OBJECTIVES: To assess diagnostic accuracy and to compare wait-times and costs of VLC and conventional clinics. METHODS: Patients with suspected melanoma referred from primary care into a publicly funded health system attended local skin imaging centres, rather than hospital outpatient clinics. A teledermatologist assessed each lesion choosing specialist assessment/excision, General Practitioner (GP) follow-up, to re-image in 3 months, or self-monitoring/no concern...
December 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
Kabilan Thanapaalasingham, André S Pollmann, Benjamin Schelew
PURPOSE: Pheochromocytomas (PHEOS) are rare catecholamine-secreting adrenal tumours requiring surgical resection. Preoperative alpha-adrenergic receptor blockade to prevent intraoperative hypertension has traditionally been achieved with phenoxybenzamine. Due to changes in the availability of phenoxybenzamine in Canada, alternate therapies are needed for patients. We report our first experience using metyrosine, a tyrosine hydroxylase inhibitor, for preoperative management in a symptomatic patient with a unilateral PHEO...
December 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
S Giusca, S Kelle, E Nagel, S J Buss, A Voss, V Puntmann, E Fleck, H A Katus, G Korosoglou
AIMS: To evaluate the prognostic significance of myocardial ischaemia and scar in patients with and without diabetes mellitus (DM) who undergo dobutamine stress cardiac magnetic resonance (DCMR) and late gadolinium enhancement (LGE) imaging for known and suspected coronary artery diseases (CADs). METHODS AND RESULTS: A total of 1969 consecutive patients [age 63 ± 12 years, 29% female, left ventricular ejection fraction = 59 ± 12%] referred for a cardiac magnetic resonance (CMR) examination including DCMR and LGE with the suspicion of CAD or progression of CAD in three tertiary cardiac centres were analysed...
July 2016: European Heart Journal Cardiovascular Imaging
Nicola Gaibazzi, Fausto Rigo, Rita Facchetti, Scipione Carerj, Cristina Giannattasio, Antonella Moreo, Gian Francesco Mureddu, Massimo Salvetti, Elisabetta Grolla, Giacomo Faden, Francesca Cesana, Pompilio Faggiano
AIMS: According to recent data, more accurate selection of patients undergoing coronary angiography for suspected coronary artery disease (CAD) is needed. From the Active PREvention Study multicentre prospective study, we further analyse whether carotid intima-media thickness (cIMT), carotid plaques (cPL), and echocardiographic cardiac calcium score (eCS) have incremental discriminatory and reclassification predictive value for CAD over clinical risk score in subjects undergoing coronary angiography, specifically depending on their low, intermediate, or high class of clinical risk...
September 2016: European Heart Journal Cardiovascular Imaging
Badriya Al-Suqri, Naima Al-Bulushi
OBJECTIVES: Although (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) has largely replaced the use of gallium-67 ((67)Ga) scintigraphy in the evaluation and follow-up of lymphoma patients, (67)Ga scans are still of value, particularly in countries where no PET/CT service is available. The current study presents the experience of a tertiary care centre using (67)Ga scintigraphy for the evaluation of lymphomas and infections. METHODS: A retrospective review was conducted of all (67)Ga scans performed between 2007 and 2011 at the Royal Hospital in Muscat, Oman...
August 2015: Sultan Qaboos University Medical Journal
Michela Pisani, Salah Al-Buheissi, Tim Whittlestone
Soft tissue sarcomas (STS) are rare and heterogeneous tumours representing approximately 0.7%-1% of all adult tumours. In the adults and among the retroperitoneal sarcomas (RPS), Liposarcoma (LS) is the most common variant accounting for 12% -20% of all sarcomas and up to 45% of sarcomas at retroperitoneal localization. A rare case of LS relapsed after 15 years is giving the occasion to review the published literature and emphasise the followings concepts: 1) Despite extensive surgery remains the mainstay of treatment for localized STS at present, anatomical complexity and occult localization result in local recurrence in the majority of patients; 2) The role of imaging and tumour markers is still limited; 3) Indefinite prolonged surveillance is a key point of treatment; 4) Referral to tertiary centres with dedicated Retroperitonal Surgeons and Oncology expertise is mandatory...
May 24, 2016: Urologia
Konstantinos Balaskas, Jane Gray, Peter Blows, Azita Rajai, Deidre Flaye, Tunde Peto, Mandeep S Sagoo
BACKGROUND: Choroidal naevomelanocytic lesions are often identified as an incidental finding by community optometrists and referred for expert evaluation in hospital eye units or specialist ocular oncology centres. Optimal management strategy is undecided and most centres err on the side of caution. Our aim was to test a virtual model of service delivery relying on interpretation of imaging test results by non-medically trained graders. METHODS: Patients with naevomelanocytic lesions referred to Manchester Royal Eye Hospital and Moorfields Eye Hospital were retrospectively included in this study...
May 2016: British Journal of Ophthalmology
G Delpon, S Chiavassa, S Supiot, C Boutry, J Darréon, J Desrousseaux, F Lafay, A Leysalle, R de Crevoisier
Image-guided radiation therapy consists in acquiring in-room images to improve patient and mainly tumour set up accuracy. Many devices based on ionising or non-ionising radiations were designed in recent years. The use of such devices is of major importance in the management of patient radiotherapy courses. Those imaging sessions require to clearly define procedures in each radiotherapy department (image modality, acquisition frequency, corrective action, staff training and tasks). A quick review of the different existing image-guided radiation therapy devices is presented...
October 2015: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Abdullah Al-Issa, Yuko Inoue, Jochen Cammin, Qiulin Tang, Saman Nazarian, Hugh Calkins, Elliot K Fishman, Katsuyuki Taguchi, Hiroshi Ashikaga
AIMS: The aim of this article is to determine the association between left atrial appendage (LAA) regional dysfunction using image-based motion-estimation computed tomography (CT) (iME) and a prior history of stroke or transient ischaemic attack (TIA) in patients with atrial fibrillation (AF). METHODS AND RESULTS: In this single-centre retrospective case-control study, among patients referred for AF ablation who underwent pre-ablation cardiac CT with retrospective ECG gating, we identified 18 patients with a prior history of stroke or TIA at the time of CT scan and 18 age- and gender-matched controls...
July 2016: European Heart Journal Cardiovascular Imaging
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