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Patient-centred imaging

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https://www.readbyqxmd.com/read/29472116/post-imaging-colorectal-cancer-or-interval-cancer-rates-after-ct-colonography-a-systematic-review-and-meta-analysis
#1
Anu E Obaro, Andrew A Plumb, Thomas R Fanshawe, Ulysses S Torres, Rachel Baldwin-Cleland, Stuart A Taylor, Steve Halligan, David N Burling
BACKGROUND: CT colonography is highly sensitive for colorectal cancer, but interval or post-imaging colorectal cancer rates (diagnosis of cancer after initial negative CT colonography) are unknown, as are their underlying causes. We did a systematic review and meta-analysis of post-CT colonography and post-imaging colorectal cancer rates and causes to address this gap in understanding. METHODS: We systematically searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials...
February 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29472097/the-influence-of-the-image-registration-method-on-the-adaptive-radiotherapy-a-proof-of-the-principle-in-a-selected-case-of-prostate-imrt
#2
Roberto Berenguer, Victoria de la Vara, Veronica Lopez-Honrubia, Ana Teresa Nuñez, Miguel Rivera, Maria Victoria Villas, Sebastia Sabater
PURPOSE: To analyse the influence of the image registration method on the adaptive radiotherapy of an IMRT prostate treatment, and to compare the dose accumulation according to 3 different image registration methods with the planned dose. MATERIAL AND METHODS: The IMRT prostate patient was CT imaged 3 times throughout his treatment. The prostate, PTV, rectum and bladder were segmented on each CT. A Rigid, a deformable (DIR) B-spline and a DIR with landmarks registration algorithms were employed...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29470857/numerical-study-on-the-hemodynamics-of-patient-specific-carotid-bifurcation-using-a-new-mesh-approach
#3
S I S Pinto, J B L M Campos, E Azevedo, C F Castro, L C Sousa
The definition of a suitable mesh to simulate blood flow in the human carotid bifurcation has been investigated. In this research, a novel mesh generation method is proposed: hexahedral cells at the centre of the vessel and a fine grid of tetrahedral cells near the artery wall, in order to correctly simulate the large blood velocity gradients associated with specific locations. The selected numerical examples to show the pertinence of the novel generation method are supported by carotid ultrasound (US) image data of a patient-specific case...
February 22, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29468003/obstructed-hemivagina-and-ipsilateral-renal-anomaly-ohvira-syndrome
#4
Aziza Al Ghafri, Alaeddin Fida, Abdulaziz Al-Gharras
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a rare congenital abnormality of the female urogenital tract. We reported OHVIRA syndrome in a 15-year-old girl, who was referred to King Faisal Specialist Hospital and Research Centre, due to hematocolpos and an imperforate hymen. The patient was diagnosed as having an absent right kidney since childhood. She presented with progressive development of lower abdominal discomfort and an abdominopelvic mass. She had no history of urinary complaints...
January 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29464815/hepatic-elastin-content-is-predictive-of-adverse-outcome-in-advanced-fibrotic-liver-disease
#5
Timothy James Kendall, Grace Elizabeth Dolman, Catherine Mary Duff, Emma Claire Paish, Abed Zaitoun, William Irving, Jonathan Andrew Fallowfield, Indra Neil Guha
AIMS: Needle biopsy remains essential for diagnosis in assessment of liver disease, although there remains associated risk. Examination is largely limited to subjective evaluation and biopsies are not exploited to provide personalised prognostic information. Elastin is a durable component of fibrotic matrix in chronic disease, conferring resistance to remodelling and potentially influencing tissue biomechanics linked to portal hypertension. We hypothesised that elastin content was predictive of clinical outcome and so could be quantified to increase the beneficial information yield from a liver biopsy...
February 21, 2018: Histopathology
https://www.readbyqxmd.com/read/29463906/noninvasive-imaging-biomarker-assessment-of-liver-fibrosis-by-elastography-in-nafld
#6
REVIEW
Elliot B Tapper, Rohit Loomba
NAFLD is a global epidemic. The prevalence of NAFLD is 20-30% in North America, northern Europe, Australia, Japan, India and China. It is crucial that patients with NAFLD receive an assessment for their risk of advanced fibrosis, which increases the risk of hepatocellular carcinoma and other complications of cirrhosis. Risk stratification that is efficient, cost-effective, patient-centred and evidence-based is one of the most important issues facing clinicians who care for those with liver disease. Given patients' preference to avoid liver biopsy, noninvasive alternatives to assess liver fibrosis are in high demand...
February 21, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29462714/alterations-of-conjunctival-glycocalyx-and-microcirculation-in-non-septic-critically-ill-patients
#7
Andrius Pranskunas, Tomas Tamosuitis, Neringa Balciuniene, Diana Damanskyte, Edvin Sneider, Astra Vitkauskiene, Edmundas Sirvinskas, Vidas Pilvinis, E Christiaan Boerma
As of now the relationship between glycocalyx degradation and microcirculatory perfusion abnormalities in non-septic critical ill patients is unclear. In addition, conjunctival sidestream dark field-imaging for the purpose of glycocalyx thickness estimation has never been performed. We aimed to investigate whether changes in glycocalyx thickness in non-septic patients are associated with microcirculatory alterations in conjunctival and sublingual mucosa. In this single-centre prospective observational study, using techniques for direct in-vivo observation of the microcirculation, we performed a single measurement of microcirculatory perfusion parameters and visualized glycocalyx thickness in both ocular conjunctiva and sublingual mucosa in mixed cardio surgical (n = 18) and neurocritical patients (n = 27) and compared these data with age-matched healthy controls (n = 20)...
February 17, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29462028/the-operative-risk-and-natural-history-after-the-diagnosis-of-ileal-penetrating-crohn-s-disease
#8
Peter Bossuyt, Celine Debeuckelaere, Marc Ferrante, Dirk Vanbeckevoort, Thomas Billiet, Albert Wolthuis, Gert van Assche, Andre D'Hoore, Séverine Vermeire
BACKGROUND AND PURPOSE: Crohn's disease (CD) is marked by transmural inflammation of the bowel wall leading to stricturing and/or penetrating complications in the majority of patients. The natural history and operative risk after the diagnosis of an ileal penetrating complication is understudied. The aim was to study the disease course and need for surgery in patients diagnosed with a penetrating ileal CD complication and to assess the risk factors associated with worse postoperative outcome...
February 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29459606/clinical-and-neuro-radiological-presentation-of-tuberous-sclerosis-complex-in-tertiary-care-centre
#9
G K Kundu, S Ahmed, S Akhter, M T Islam, T Dwa, A M Sabbir
Tuberous sclerosis complex (TSC) is a common neurocutaneous disorder characterized by hamartomatous changes in the lungs, brain, kidneys, skin, heart, and other organs. This retrospective study was done to see the clinical presentation and neuro imaging pattern of TSC in a tertiary care centre of Bangladesh and was conducted at Pediatric Neurology Unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2013 to December 2013. Among total 10 patients male-female ratio was 3:2...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29458219/clinical-endocrine-and-imaging-characteristics-of-patients-with-primary-hypophysitis
#10
Anna Angelousi, Carolina Cohen, Soledad Sosa, Karina Danilowicz, Lina Papanastasiou, Marina Tsoli, Aparna Pal, Georgios Piaditis, Ashley Grossman, Gregory Kaltsas
Primary hypophysitis (PH) is a rare disease with a poorly-defined natural history. Our aim was to characterise patients with PH at presentation and during prolonged follow-up. Observational retrospective study of 22 patients was conducted from 3 centres. In 14 patients, PH was confirmed histologically and in the remaining 8 clinically, after excluding secondary causes of hypophysitis. All patients had hormonal and imaging investigations before any treatment. Median follow up was 48 months (25-75%: 3-60). There was a female predominance with a female/male ratio: 3...
February 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29457381/a-multicentre-study-of-validity-and-reliability-of-responses-to-hand-cold-challenge-as-measured-by-laser-speckle-contrast-imaging-and-thermography-outcome-measures-for-systemic-sclerosis-related-raynaud-s-phenomenon
#11
Jack D Wilkinson, Sarah A Leggett, Elizabeth J Marjanovic, Tonia L Moore, John Allen, Marina E Anderson, Jason Britton, Maya H Buch, Francesco Del Galdo, Christopher P Denton, Graham Dinsdale, Bridgett Griffiths, Frances Hall, Kevin Howell, Audrey MacDonald, Neil J McHugh, Joanne B Manning, John D Pauling, Christopher Roberts, Jacqueline A Shipley, Ariane L Herrick, Andrea K Murray
BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography...
February 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29456738/recurrence-of-adenoid-cystic-carcinoma-of-the-trachea-treated-with-radical-radiotherapy-a-case-report
#12
Konrad Pawlewicz, Zbigniew Szutkowski, Andrzej Kawecki
Adenoid cystic carcinoma (ACC) of the trachea is a relatively rare tumor among thoracic diseases. The present study reports the case of a 23-year-old woman with ACC of the trachea who underwent surgical resection of the tumor in The National Institute of Tuberculosis and Lung Diseases (Warsaw, Poland). Histopathological examination revealed that the tumor was not completely resected (R2 resection) and strict observation of the patient was therefore prescribed. After ~9 years of follow-up, clinical and histopathological tumor progression was confirmed and the patient was referred to the Centre of Oncology in Warsaw...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29455348/the-effect-of-the-anterior-boundary-of-necrotic-lesion-on-the-occurrence-of-collapse-in-osteonecrosis-of-the-femoral-head
#13
Yusuke Kubo, Goro Motomura, Satoshi Ikemura, Kazuhiko Sonoda, Hiroyuki Hatanaka, Takeshi Utsunomiya, Shoji Baba, Yasuharu Nakashima
PURPOSE: The location of the necrotic lesion is one of the important factors for collapse in osteonecrosis of the femoral head (ONFH). The significance of anterior localization has been little studied. This study evaluated the effects of anterior boundary of a necrotic lesion on collapse. METHODS: We reviewed the outcomes of 113 consecutive non-collapsed asymptomatic hips in 98 ONFH patients with mean follow-up of 4.7 years (2.0-11.8) after the initial magnetic resonance (MR) imaging...
February 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29454314/a-prospective-study-to-investigate-the-role-of-serial-serum-mesothelin-in-monitoring-mesothelioma
#14
Duneesha de Fonseka, David T Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo, Nick A Maskell
BACKGROUND: Radiological monitoring of malignant pleural mesothelioma (MPM) using modified RECIST criteria is limited by low sensitivity and inter-observer variability. Serial serum mesothelin measurement has shown utility in the assessment of treatment response during chemotherapy but has never been assessed in the longer term follow up of patients. METHODS: This is a single centre study of consecutive patients diagnosed with MPM who received chemotherapy or best supportive care (BSC)...
February 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29445521/a-method-for-co-creation-of-an-evidence-based-patient-workbook-to-address-alcohol-use-when-quitting-smoking-in-primary-care-a-case-study
#15
Nadia Minian, Aliya Noormohamed, Laurie Zawertailo, Dolly Baliunas, Norman Giesbrecht, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
Plain English summary: The purpose of this paper is to describe a patient engagement event designed to create an educational workbook with smokers who drink alcohol at harmful levels. The goal was to create a workbook that combined scientific evidence with patients' values, preferences, and needs. Fourteen adult smokers who drink alcohol were invited to the Centre for Addiction and Mental Health (CAMH) to take part in a four-hour event to help design the workbook with the CAMH research team...
2018: Research involvement and engagement
https://www.readbyqxmd.com/read/29439672/renal-manifestations-of-tuberous-sclerosis-complex-patients-and-parents-knowledge-and-routines-for-renal-follow-up-a-questionnaire-study
#16
I Cockerell, M Guenin, K Heimdal, M Bjørnvold, K K Selmer, O Rouvière
BACKGROUND: Renal angiomyolipomas (AMLs) are a major clinical feature in patients with tuberous sclerosis complex (TSC). Spontaneous bleeding can be life threatening, and appropriate information and proper surveillance and management are important to limit morbidity and mortality. Because TSC is a rare disease, patients are at risk of suboptimal medical management. Our aim was to investigate patients' and parents' knowledge about renal angiomyolipomas (AMLs) in Tuberous Sclerosis Complex (TSC) and to identify current routines for renal follow-up...
February 13, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29438856/the-surgical-management-of-dysphagia-secondary-to-diffuse-idiopathic-skeletal-hyperostosis
#17
Y C Lui Jonathan, P Sayal, G Prezerakos, V Russo, D Choi, A T H Casey
OBJECTIVE: This study reviews the management pathway and surgical outcomes of patients referred to and operated on at a tertiary neurosurgical centre, for dysphagia associated with anterolateral cervical hyperostosis (ACH) in diffuse idiopathic skeletal hyperostosis (DISH). PATIENTS & METHODS: Electronic patient records for 6 patients who had undergone anterior cervical osteophytectomy for dysphagia secondary to ACH were reviewed. ACH diagnosis was made by an Ear, Nose and Throat (ENT) specialist and patients were referred to a neurosurgical-led multidisciplinary team (MDT) for review...
February 7, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29438587/managing-penetrating-renal-trauma-experience-from-two-uk-major-trauma-centres
#18
Marios Hadjipavlou, Edmund Grouse, Robert Gray, Denosshan Sri, Dean Huang, Christian Brown, Davendra Sharma
OBJECTIVES: To present our series of patients with penetrating renal trauma from two urban major trauma centres and discuss contemporary management of these injuries. METHODS: We reviewed prospective urological trauma databases for all patients presenting with penetrating renal trauma between January 2005 and October 2016. Patient demographics, clinical characteristics, imaging, management and follow-up data were analysed. RESULTS: Over the 11 year period, 63 patients presented with penetrating renal injuries...
February 13, 2018: BJU International
https://www.readbyqxmd.com/read/29433826/cancer-cervix-establishing-an-evidence-based-strategy-an-experience-of-a-tertiary-care-centre-in-india
#19
Shyam Kishore Shrivastava, Shirley Lewis, Supriya Chopra Sastri, G Lavanya, Umesh Mahantshetty, Reena Engineer
Carcinoma cervix is a common cancer among Indian women. Evidence based management is essential for best practice in treatment of carcinoma cervix for its effective control. The current imaging system like CT, MRI and PET CT scans have contributed in identifying the patients for optimal treatment and delivering treatment accurately. For stages IB2 to IV, concurrent chemoradiation is advocated with improvement in overall survival proven with randomized trials. Brachytherapy is an integral part in the radiation treatment...
January 12, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29432656/improving-the-efficacy-of-pet-ct-imaging-in-head-and-neck-cancer-management-and-surveillance-through-the-multidisciplinary-team-a-multi-centre-retrospective-cohort-analysis-of-51-patients
#20
Matthew Haywood, Liam Masterton, Aaron Cronin, Ananth Vijendren, Thayahlan Iyngkaran, Prasad Kothari, Chi-Hwa Chan, Andrew Camilleri
There has been a recent move towards image-guided surveillance of N2/N3 disease in HNSCC and neck dissection only in selected cases PET-CT demand is rising and alters management in a third of HNSCC patients PET-CT is expensive and can lead to unnecessary and harmful investigations, delaying treatment The MDT is significantly less likely to request an inappropriate PET-CT than the individual clinician Collaboration among specialists may minimise the ordering of inappropriate PET-CTs, reducing costs and improving patient safety and management...
February 12, 2018: Clinical Otolaryngology
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