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Pilar X Altman, Gabriel Ozorowski, Robyn L Stanfield, Jeremy Haakenson, Michael Appel, Mara Parren, Wen-Hsin Lee, Huldah Sang, Jordan Woehl, Karen Saye-Francisco, Collin Joyce, Ge Song, Katelyn Porter, Elise Landais, Raiees Andrabi, Ian A Wilson, Andrew B Ward, Waithaka Mwangi, Vaughn V Smider, Dennis R Burton, Devin Sok
UNLABELLED: The generation of broadly neutralizing antibodies (bnAbs) to specific HIV epitopes of the HIV Envelope (Env) is one of the cornerstones of HIV vaccine research. The current animal models we use have been unable to reliable produce a broadly neutralizing antibody response, with the exception of cows. Cows have rapidly and reliably produced a CD4 binding site response by homologous prime and boosting with a native-like Env trimer. In small animal models other engineered immunogens previously have been able to focus antibody responses to the bnAb V2-apex region of Env...
February 14, 2024: bioRxiv
#22
JOURNAL ARTICLE
Miira M Klemetti, Ante B V Pettersson, Aafaque Ahmad Khan, Leonardo Ermini, Tyler R Porter, Michael L Litvack, Sruthi Alahari, Stacy Zamudio, Nicholas P Illsley, Hannes Röst, Martin Post, Isabella Caniggia
Small-for-gestational age (SGA) neonates exhibit increased perinatal morbidity and mortality, and a greater risk of developing chronic diseases in adulthood. Currently, no effective maternal blood-based screening methods for determining SGA risk are available. We used a high-resolution MS/MSALL shotgun lipidomic approach to explore the lipid profiles of small extracellular vesicles (sEV) released from the placenta into the circulation of pregnant individuals. Samples were acquired from 195 normal and 41 SGA pregnancies...
February 2024: Journal of Extracellular Vesicles
#23
JOURNAL ARTICLE
Jonathan L Wright, Jeannette M Schenk, Roman Gulati, Sarah J Beatty, Matthew VanDoren, Daniel W Lin, Michael P Porter, Colm Morrissey, Atreya Dash, John L Gore, Ruth Etzioni, Stephen R Plymate, Marian L Neuhouser
BACKGROUND: Active surveillance (AS) is increasingly used to monitor patients with lower risk prostate cancer (PCa). The Prostate Cancer Active Lifestyle Study (PALS) was a randomized controlled trial to determine whether weight loss improves obesity biomarkers on the causal pathway to progression in patients with PCa on AS. METHODS: Overweight/obese men (body mass index >25 kg/m2 ) diagnosed with PCa who elected AS were recruited. The intervention was a 6-month, individually delivered, structured diet and exercise program adapted from the Diabetes Prevention Program with a 7% weight loss goal from baseline...
February 14, 2024: Cancer
#24
JOURNAL ARTICLE
Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hastbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) posed a threat to public health and the global economy, necessitating the development of various vaccination strategies. Mutations in the SPIKE protein gene, a crucial component of mRNA and adenovirus-based vaccines, raised concerns about vaccine efficacy, prompting the need for rapid vaccine updates. To address this, we leveraged PeptiCRAd, an oncolytic vaccine based on tumor antigen decorated oncolytic adenoviruses, creating a vaccine platform called PeptiVAX...
February 6, 2024: International Journal of Biological Macromolecules
#25
JOURNAL ARTICLE
Gregory Knell, Kathryn Burford, Tammy Calise, Erin E Dooley, Augusto Ferreira de Moraes, Leigh Ann Ganzar, Ho Han, Natalia Heredia, Alejandra Jáuregui, Ashleigh Johnson, Kevin Lanza, Eileen Nehme, Hildi Nicksic, Abiodun O Oluyomi, Anna Porter, Andrea Ramirez Varela, Michael Robertson, Deborah Salvo, Timothy Walker, Yuzi Zhang
No abstract text is available yet for this article.
February 1, 2024: Journal of Physical Activity & Health
#26
JOURNAL ARTICLE
Douglas M Whiteside, Michael R Basso, Chen Shen, Laura Fry, Savana Naini, Eric J Waldron, Erin Holker, Jim Porter, Courtney Eskridge, Allison Logemann, Greta N Minor
INTRODUCTION: Performance validity test (PVT) failures occur in clinical practice and at higher rates with external incentives. However, little PVT research has been applied to the Long COVID population. This study aims to address this gap. METHODS: Participants were 247 consecutive individuals with Long COVID seen for neuropsychological evaluation who completed 4 PVTs and a standardized neuropsychological battery. The sample was 84.2% White and 66% female. The mean age was 51...
February 1, 2024: Journal of Clinical and Experimental Neuropsychology
#27
JOURNAL ARTICLE
Elena Currie, Bronwyn Granata, Greg Goodman, Alice Rudd, Katy Wallace, Alexander Rivkin, Sarah Hart, Catherine E Porter, Steven Harris, Lee Walker, Frank Lin, Niamh Corduff, Nik Davies, Stefania Roberts, Michael Clague, Peter P Callan, Cara McDonald, Mark Magnusson, Angelo Tsirbas, Ritu Gupta, Philip Bekhor, Belinda Welsh
No abstract text is available yet for this article.
January 23, 2024: Aesthetic Surgery Journal
#28
Anand G Patel, Orr Ashenberg, Natalie B Collins, Åsa Segerstolpe, Sizun Jiang, Michal Slyper, Xin Huang, Chiara Caraccio, Hongjian Jin, Heather Sheppard, Ke Xu, Ti-Cheng Chang, Brent A Orr, Abbas Shirinifard, Richard H Chapple, Amber Shen, Michael R Clay, Ruth G Tatevossian, Colleen Reilly, Jaimin Patel, Marybeth Lupo, Cynthia Cline, Danielle Dionne, Caroline B M Porter, Julia Waldman, Yunhao Bai, Bokai Zhu, Irving Barrera, Evan Murray, Sébastien Vigneau, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Grace Grimaldi, Laura Dellostritto, Karla Helvie, Asaf Rotem, Ana Lako, Nicole Cullen, Kathleen L Pfaff, Åsa Karlström, Judit Jané-Valbuena, Ellen Todres, Aaron Thorner, Paul Geeleher, Scott J Rodig, Xin Zhou, Elizabeth Stewart, Bruce E Johnson, Gang Wu, Fei Chen, Jiyang Yu, Yury Goltsev, Garry P Nolan, Orit Rozenblatt-Rosen, Aviv Regev, Michael A Dyer
Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma patient tumors, collected from two pediatric cancer institutions, spanning a range of clinical, genetic, and histologic features. Our atlas combines single-cell/nucleus RNA-seq (sc/scRNA-seq), bulk RNA-seq, whole exome sequencing, DNA methylation profiling, spatial transcriptomics, and two spatial proteomic methods...
January 16, 2024: bioRxiv
#29
JOURNAL ARTICLE
Cathy Snapp, Brandon Byrd, Michael Porter
INTRODUCTION: The complication of delirium for hip fracture patients is a predictor of mortality. Use of opioid medication increases the incidence of delirium in the pre- and postoperative periods. Regional nerve blocks are effective in managing acute pain for acute hip fractures. This study aims to evaluate the utilization of ED physicians to perform fascia iliaca nerve blocks on hip fracture patients to decrease the incidence of delirium by decreasing usage of opioid medication. METHODS: A quality improvement project for performing regional nerve blocks on patients with femoral neck fractures was implemented during fiscal year 2019...
2024: Geriatric Orthopaedic Surgery & Rehabilitation
#30
JOURNAL ARTICLE
Kristin Gabor, Emily V Mesev, Jennifer Madenspacher, Julie M Meacham, Prashant Rai, Sookjin Moon, Christopher A Wassif, Saame Raza Shaikh, Charles J Tucker, Peer W Karmaus, Simona Bianconi, Forbes D Porter, Michael B Fessler
No abstract text is available yet for this article.
January 18, 2024: Journal of Clinical Investigation
#31
JOURNAL ARTICLE
Bruce L Levine, Marcelo C Pasquini, John E Connolly, David L Porter, Michael P Gustafson, Jaap J Boelens, Edwin M Horwitz, Stephan A Grupp, Marcela V Maus, Frederick L Locke, Fabio Ciceri, Annalisa Ruggeri, John Snowden, Helen E Heslop, Crystal L Mackall, Carl H June, Anna M Sureda, Miguel-Angel Perales
No abstract text is available yet for this article.
February 2024: Nature Medicine
#32
JOURNAL ARTICLE
Malik A Althobiani, Rebecca Shuttleworth, John Conway, Jonathan Dainton, Anna Duckworth, Ana Jorge Da Ponte, Jessica Mandizha, Joseph W Lanario, Michael A Gibbons, Sarah Lines, Chris J Scotton, John R Hurst, Joanna C Porter, Anne-Marie Russell
INTRODUCTION: Patients diagnosed with Interstitial Lung Diseases (ILD) use devices to self-monitor their health and well-being. Little is known about the range of devices, selection, frequency and terms of use and overall utility. We sought to quantify patients' usage and experiences with home digital devices, and further evaluate their perceived utility and barriers to adaptation. METHODS: A team of expert clinicians and patient partners interested in self-management approaches designed a 48-question cross-sectional electronic survey; specifically targeted at individuals diagnosed with ILD...
January 2024: PLOS Digit Health
#33
JOURNAL ARTICLE
Antony M Knights, Anaëlle J Lemasson, Louise B Firth, Todd Bond, Jeremy Claisse, Joop W P Coolen, Andrea Copping, Jennifer Dannheim, Michela De Dominicis, Steven Degraer, Michael Elliott, Paul G Fernandes, Ashley M Fowler, Matt Frost, Lea-Anne Henry, Natalie Hicks, Kieran Hyder, Sylvia Jagerroos, Daniel O B Jones, Milton Love, Christopher P Lynam, Peter I Macreadie, Joseph Marlow, Ninon Mavraki, Dianne McLean, Paul A Montagna, David M Paterson, Martin Perrow, Joanne Porter, Debbie J F Russell, Ann Scarborough Bull, Michaela Schratzberger, Brooke Shipley, Sean van Elden, Jan Vanaverbeke, Andrew Want, Stephen C L Watson, Thomas A Wilding, Paul Somerfield
Thousands of artificial ('human-made') structures are present in the marine environment, many at or approaching end-of-life and requiring urgent decisions regarding their decommissioning. No consensus has been reached on which decommissioning option(s) result in optimal environmental and societal outcomes, in part, owing to a paucity of evidence from real-world decommissioning case studies. To address this significant challenge, we asked a worldwide panel of scientists to provide their expert opinion. They were asked to identify and characterise the ecosystem effects of artificial structures in the sea, their causes and consequences, and to identify which, if any, should be retained following decommissioning...
January 6, 2024: Journal of Environmental Management
#34
JOURNAL ARTICLE
Charles D Mabry, Benjamin Davis, Michael Sutherland, Ronald Robertson, Jennifer Carger, Deidre Wyrick, Terry Collins, Austin Porter, Kyle Kalkwarf
BACKGROUND: The state legislature codified and funded the Arkansas Trauma System (ATS) in 2009. Quarterly Preventable Mortality Reviews (PMR) by the ATS began in 2015 and were used to guide state-wide targeted education to reduce Preventable or Potentially Preventable deaths (P/PP). We present the results of this PMR-education initiative from 2015 to 2022. STUDY DESIGN: The ATS uses a statistical sampling model of the Arkansas Trauma Registry (ATR) to select ~40% of the deaths for quarterly review, reflecting the overall ATR mortality population...
December 27, 2023: Journal of the American College of Surgeons
#35
JOURNAL ARTICLE
Bogdan Sieriebriennikov, Megan L Porter, Jakub Mlejnek, Keith Short, Fleur Lebhardt, Isabel Holguera, Claude Desplan, Michael W Perry
No abstract text is available yet for this article.
2023: Frontiers in Genetics
#36
JOURNAL ARTICLE
Mikesh Patel, Nafsika Forte, Charlie R Bishop, Michael J Porter, Matthew Dagwell, Kersti Karu, Vijay Chudasama, James R Baker
Electron-poor aryl nitriles are promising reagents for bioconjugation due to their high electrophilicity and selectivity for reaction with thiols, albeit generally in a reversible manner. A transient species has previously been observed in such reactions, involving the addition of two thiols to the nitrile functional group, forming a tetrahedral amino dithioacetal (ADTA). In this work, the reaction of heteroaryl nitriles with bis-thiols is explored in an attempt to generate stable ADTAs, which could facilitate new bioconjugation protocols...
December 20, 2023: Journal of the American Chemical Society
#37
Jonas Kath, Clemens Franke, Vanessa Drosdek, Weijie Du, Viktor Glaser, Carla Fuster-Garcia, Maik Stein, Tatiana Zittel, Sarah Schulenberg, Caroline E Porter, Lena Andersch, Annette Künkele, Joshua Alcaniz, Jens Hoffmann, Hinrich Abken, Mohamed Abou-El-Enein, Axel Pruß, Masataka Suzuki, Toni Cathomen, Renata Stripecke, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse, Dimitrios L Wagner
UNLABELLED: Chimeric antigen receptor (CAR)-reprogrammed immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies rely on personalized manufacturing using undirected viral gene transfer, which results in non-physiological regulation of CAR-signaling and limits their accessibility due to logistical challenges, high costs and biosafety requirements. Here, we propose a novel approach utilizing CRISPR-Cas gene editing to redirect T cells and natural killer (NK) cells with CARs...
November 14, 2023: bioRxiv
#38
JOURNAL ARTICLE
Guido Ghilardi, Luca Paruzzo, Jakub Svoboda, Elise A Chong, Alexander A Shestov, Linhui Chen, Ivan J Cohen, Giulia Gabrielli, Sunita D Nasta, Patrizia Porazzi, Daniel J Landsburg, James N Gerson, Jordan Carter, Stefan K Barta, Rebecca Dawn Yelton, Raymone Pajarillo, Vrutti Patel, Griffin White, Hatcher Ballard, Elizabeth Weber, Ellen B Napier, Emeline R Chong, Joseph A Fraietta, Alfred Garfall, David L Porter, Michael C Milone, Roddy S O'Connor, Stephen J Schuster, Marco Ruella
Lymphodepletion (LD) is an integral component of chimeric antigen receptor T cell immunotherapies (CART). In this study, we compared the safety and efficacy of bendamustine (Benda) with standard fludarabine/cyclophosphamide (Flu/Cy) LD before CD19-directed, CD28-costimulated CART axicabtagene ciloleucel (axi-cel) in patients with large B-cell lymphomas (LBCL) and follicular lymphoma (FL). We analyzed 59 patients diagnosed with LBCL (48) and FL (11) consecutively treated with axi-cel at the University of Pennsylvania...
December 19, 2023: Blood Advances
#39
JOURNAL ARTICLE
Léa N C Rochet, Calise Bahou, Jonathan P Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J Spears, Ioanna A Thanasi, Baihao Shao, Lisha Zhong, Dejan-Krešimir Bučar, Abil E Aliev, Michael J Porter, Molly M Stevens, James R Baker, Vijay Chudasama
Reversible cysteine modification has been found to be a useful tool for a plethora of applications such as selective enzymatic inhibition, activity-based protein profiling and/or cargo release from a protein or a material. However, only a limited number of reagents display reliable dynamic/reversible thiol modification and, in most cases, many of these reagents suffer from issues of stability, a lack of modularity and/or poor rate tunability. In this work, we demonstrate the potential of pyridazinediones as novel reversible and tuneable covalent cysteine modifiers...
December 6, 2023: Chemical Science
#40
JOURNAL ARTICLE
Kariem El-Boghdadly, Eric Albrecht, Morné Wolmarans, Edward R Mariano, Sandra Kopp, Anahi Perlas, Athmaja Thottungal, Jeff Gadsden, Serkan Tulgar, Sanjib Adhikary, Jose Aguirre, Anne M R Agur, Başak Altıparmak, Michael J Barrington, Nigel Bedforth, Rafael Blanco, Sébastien Bloc, Karen Boretsky, James Bowness, Margaretha Breebaart, David Burckett-St Laurent, Brendan Carvalho, Jacques E Chelly, Ki Jinn Chin, Alwin Chuan, Steve Coppens, Ioana Costache, Mette Dam, Matthias Desmet, Shalini Dhir, Christian Egeler, Hesham Elsharkawy, Thomas Fichtner Bendtsen, Ben Fox, Carlo D Franco, Philippe Emmanuel Gautier, Stuart Alan Grant, Sina Grape, Carrie Guheen, Monica W Harbell, Peter Hebbard, Nadia Hernandez, Rosemary M G Hogg, Margaret Holtz, Barys Ihnatsenka, Brian M Ilfeld, Vivian H Y Ip, Rebecca L Johnson, Hari Kalagara, Paul Kessler, M Kwesi Kwofie, Linda Le-Wendling, Philipp Lirk, Clara Lobo, Danielle Ludwin, Alan James Robert Macfarlane, Alexandros Makris, Colin McCartney, John McDonnell, Graeme A McLeod, Stavros G Memtsoudis, Peter Merjavy, E M Louise Moran, Antoun Nader, Joseph M Neal, Ahtsham U Niazi, Catherine Njathi-Ori, Brian D O'Donnell, Matt Oldman, Steven L Orebaugh, Teresa Parras, Amit Pawa, Philip Peng, Steven Porter, Bridget P Pulos, Xavier Sala-Blanch, Andrea Saporito, Axel R Sauter, Eric S Schwenk, Maria Paz Sebastian, Navdeep Sidhu, Sanjay Kumar Sinha, Ellen M Soffin, James Stimpson, Raymond Tang, Ban C H Tsui, Lloyd Turbitt, Vishal Uppal, Geert J van Geffen, Kris Vermeylen, Kamen Vlassakov, Thomas Volk, Jeff L Xu, Nabil M Elkassabany
BACKGROUND: Inconsistent nomenclature and anatomical descriptions of regional anesthetic techniques hinder scientific communication and engender confusion; this in turn has implications for research, education and clinical implementation of regional anesthesia. Having produced standardized nomenclature for abdominal wall, paraspinal and chest wall regional anesthetic techniques, we aimed to similarly do so for upper and lower limb peripheral nerve blocks. METHODS: We performed a three-round Delphi international consensus study to generate standardized names and anatomical descriptions of upper and lower limb regional anesthetic techniques...
November 22, 2023: Regional Anesthesia and Pain Medicine
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