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Michael Porter

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https://www.readbyqxmd.com/read/29599499/neurons-in-the-pigeon-nidopallium-caudolaterale-display-value-related-activity
#1
Madeline Dykes, Aylin Klarer, Blake Porter, Jonas Rose, Michael Colombo
We recorded from neurons in the nidopallium caudolaterale, the avian equivalent of the mammalian prefrontal cortex, in four birds. The birds were required to peck a stimulus that indicated the amount of reward they would receive (small or large) after a certain delay (short or long). We found that the activity of neurons in the nidopallium caudolaterale was modulated by the value of the reward that would be received based on the reward amount and the delay to reward. We found that value coding was most prominent during the presentation of the sample period, and less so during the delay period and during the presentation of the reward itself...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29587128/direct-analysis-of-pathogenic-structures-affixed-to-the-tympanic-membrane-during-chronic-otitis-media
#2
Guillermo L Monroy, Wenzhou Hong, Pawjai Khampang, Ryan G Porter, Michael A Novak, Darold R Spillman, Ronit Barkalifa, Eric J Chaney, Joseph E Kerschner, Stephen A Boppart
Objective To characterize otitis media-associated structures affixed to the mucosal surface of the tympanic membrane (TM) in vivo and in surgically recovered in vitro samples. Study Design Prospective case series without comparison. Setting Outpatient surgical care center. Subjects and Methods Forty pediatric subjects scheduled for tympanostomy tube placement surgery were imaged intraoperatively under general anesthesia. Postmyringotomy, a portable optical coherence tomography (OCT) imaging system assessed for the presence of any biofilm affixed to the mucosal surface of the TM...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29581861/the-circadian-clock-regulates-cisplatin-induced-toxicity-and-tumor-regression-in-melanoma-mouse-and-human-models
#3
Panshak P Dakup, Kenneth I Porter, Alexander A Little, Rajendra P Gajula, Hui Zhang, Elena Skornyakov, Michael G Kemp, Hans P A Van Dongen, Shobhan Gaddameedhi
Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human subjects have shown that the time of day of cisplatin treatment influences renal and blood toxicities. We hypothesized that the mechanisms responsible for these outcomes are driven by the circadian clock. We conducted experiments using wild-type and circadian disrupted Per1/2-/- mice treated with cisplatin at selected morning (AM) and evening (PM) times...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29552381/pneumatic-low-coherence-interferometry-otoscope-to-quantify-tympanic-membrane-mobility-and-middle-ear-pressure
#4
Jungeun Won, Guillermo L Monroy, Pin-Chieh Huang, Roshan Dsouza, Malcolm C Hill, Michael A Novak, Ryan G Porter, Eric Chaney, Ronit Barkalifa, Stephen A Boppart
Pneumatic otoscopy to assess the mobility of the tympanic membrane (TM) is a highly recommended diagnostic method of otitis media (OM), a widespread middle ear infection characterized by the fluid accumulation in the middle ear. Nonetheless, limited depth perception and subjective interpretation of small TM displacements have challenged the appropriate and efficient examination of TM dynamics experienced during OM. In this paper, a pneumatic otoscope integrated with low coherence interferometry (LCI) was adapted with a controlled pressure-generating system to record the pneumatic response of the TM and to estimate middle ear pressure (MEP)...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29535426/mutant-il-7r%C3%AE-and-mutant-nras-are-sufficient-to-induce-murine-t-cell-acute-lymphoblastic-leukemia
#5
Sarah D Cramer, Julie A Hixon, Caroline Andrews, Ross J Porter, Gisele O L Rodrigues, Xiaolin Wu, Tim Back, Kelli Czarra, Helen Michael, Maggie Cam, Jack Chen, Dominic Esposito, Emilee Senkevitch, Vijay Negi, Peter D Aplan, Wenqing Li, Scott K Durum
No abstract text is available yet for this article.
February 15, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29521796/a-selective-placement-strategy-for-surgical-feeding-tubes-benefits-trauma-patients
#6
Joseph Marcotte, Joshua Hazelton, Chirag Arya, Michael Dalton, Amber Batool, John Gaughan, Linh Nguyen, John Porter, Nicole Fox
BACKGROUND: The indications for surgical feeding tube (SFT) placement in trauma patients are poorly defined. Patient selection is critical as complications from SFTs have been reported in up to 70% of patients. A previous analysis by our group determined that 25% of the SFTs we placed were unnecessary and that older patients, patients with head and spinal cord injuries, and patients who needed a tracheostomy were more likely to require long term SFTs. Following this study, we modified our institutional guidelines for SFT placement...
March 8, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29521452/genomes-of-ubiquitous-marine-and-hypersaline-hydrogenovibrio-thiomicrorhabdus-and-thiomicrospira-spp-encode-a-diversity-of-mechanisms-to-sustain-chemolithoautotrophy-in-heterogeneous-environments
#7
Kathleen M Scott, John Williams, Cody M B Porter, Sydney Russel, Tara L Harmer, John H Paul, Kirsten M Antonen, Megan K Bridges, Gary J Camper, Christie K Campla, Leila G Casella, Eva Chase, James W Conrad, Mercedez C Cruz, Darren S Dunlap, Laura Duran, Elizabeth M Fahsbender, Dawn B Goldsmith, Ryan F Keeley, Matthew R Kondoff, Breanna I Kussy, Marannda K Lane, Stephanie Lawler, Brittany A Leigh, Courtney Lewis, Lygia M Lostal, Devon Marking, Paola A Mancera, Evan C McClenthan, Emily A McIntyre, Jessica A Mine, Swapnil Modi, Brittney D Moore, William A Morgan, Kaleigh M Nelson, Kimmy N Nguyen, Nicholas Ogburn, David G Parrino, Anangamanjari D Pedapudi, Rebecca P Pelham, Amanda M Preece, Elizabeth A Rampersad, Jason C Richardson, Christina M Rodgers, Brent L Schaffer, Nancy E Sheridan, Michael R Solone, Zachery R Staley, Maki Tabuchi, Ramond J Waide, Pauline W Wanjugi, Suzanne Young, Alicia Clum, Chris Daum, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Natalia Mikhailova, Krishnaveni Palaniappan, Manoj Pillay, T B K Reddy, Nicole Shapiro, Dimitrios Stamatis, Neha Varghese, Tanja Woyke, Rich Boden, Sharyn K Freyermuth, Cheryl A Kerfeld
Chemolithoautotrophic bacteria from the genera Hydrogenovibrio, Thiomicrorhabdus, and Thiomicrospira are common, sometimes dominant, isolates from sulfidic habitats including hydrothermal vents, soda and salt lakes, and marine sediments. Their genome sequences confirm their membership in a deeply branching clade of the Gammaproteobacteria. Several adaptations to heterogeneous habitats are apparent. Their genomes include large numbers of genes for sensing and responding to their environment (EAL- and GGDEF-domain proteins, and methyl-accepting chemotaxis proteins) despite their small sizes (2...
March 9, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29521137/psychological-factors-associated-with-episodic-chelation-adherence-in-thalassemia
#8
Jane Vosper, Michael Evangeli, John B Porter, Farrukh Shah
β-Thalassemia major (β-TM) is a life-long genetic hemoglobin (Hb) disorder requiring intensive treatment regimens, including frequent blood transfusions and daily chelation therapy. Understanding psychosocial correlates of chelation adherence is important for developing interventions to improve adherence. This study investigated within-participant correlates of oral chelation adherence on a daily (episodic) basis. Thirty-seven adult participants with β-TM were recruited from clinics at two hospitals (22 males, 9 females, mean age 34...
March 9, 2018: Hemoglobin
https://www.readbyqxmd.com/read/29503868/einstein-home-discovers-a-radio-quiet-gamma-ray-millisecond-pulsar
#9
Colin J Clark, Holger J Pletsch, Jason Wu, Lucas Guillemot, Matthew Kerr, Tyrel J Johnson, Fernando Camilo, David Salvetti, Bruce Allen, David Anderson, Carsten Aulbert, Christian Beer, Oliver Bock, Andres Cuéllar, Heinz-Bernd Eggenstein, Henning Fehrmann, Michael Kramer, Shawn A Kwang, Bernd Machenschalk, Lars Nieder, Markus Ackermann, Marco Ajello, Luca Baldini, Jean Ballet, Guido Barbiellini, Denis Bastieri, Ronaldo Bellazzini, Elisabetta Bissaldi, Roger D Blandford, Elliott D Bloom, Raffaella Bonino, Eugenio Bottacini, Terri J Brandt, Johan Bregeon, Philippe Bruel, Rolf Buehler, Toby H Burnett, Sara Buson, Rob A Cameron, Regina Caputo, Patrizia A Caraveo, Elisabetta Cavazzuti, Claudia Cecchi, Eric Charles, Alexandre Chekhtman, Stefano Ciprini, Lynn R Cominsky, Denise Costantin, Sara Cutini, Filippo D'Ammando, Andrea De Luca, Rachele Desiante, Leonardo Di Venere, Mattia Di Mauro, Niccolò Di Lalla, Seth W Digel, Cecilia Favuzzi, Elizabeth C Ferrara, Anna Franckowiak, Yasushi Fukazawa, Stefan Funk, Piergiorgio Fusco, Fabio Gargano, Dario Gasparrini, Nico Giglietto, Francesco Giordano, Marcello Giroletti, Germán A Gomez-Vargas, David Green, Isabelle A Grenier, Sylvain Guiriec, Alice K Harding, John W Hewitt, Deirdre Horan, Guðlaugur Jóhannesson, Shiki Kensei, Michael Kuss, Giovanni La Mura, Stefan Larsson, Luca Latronico, Jian Li, Francesco Longo, Francesco Loparco, Michael N Lovellette, Pasquale Lubrano, Jeffrey D Magill, Simone Maldera, Alberto Manfreda, Mario N Mazziotta, Julie E McEnery, Peter F Michelson, Nestor Mirabal, Warit Mitthumsiri, Tsunefumi Mizuno, Maria Elena Monzani, Aldo Morselli, Igor V Moskalenko, Eric Nuss, Takashi Ohsugi, Nicola Omodei, Monica Orienti, Elena Orlando, Michele Palatiello, Vaidehi S Paliya, Francesco de Palma, David Paneque, Jeremy S Perkins, Massimo Persic, Melissa Pesce-Rollins, Troy A Porter, Giacomo Principe, Silvia Rainò, Riccardo Rando, Paul S Ray, Massimiliano Razzano, Anita Reimer, Olaf Reimer, Roger W Romani, Pablo M Saz Parkinson, Carmelo Sgrò, Eric J Siskind, David A Smith, Francesca Spada, Gloria Spandre, Paolo Spinelli, Jana B Thayer, David J Thompson, Diego F Torres, Eleonora Troja, Giacomo Vianello, Kent Wood, Matthew Wood
Millisecond pulsars (MSPs) are old neutron stars that spin hundreds of times per second and appear to pulsate as their emission beams cross our line of sight. To date, radio pulsations have been detected from all rotation-powered MSPs. In an attempt to discover radio-quiet gamma-ray MSPs, we used the aggregated power from the computers of tens of thousands of volunteers participating in the Einstein@Home distributed computing project to search for pulsations from unidentified gamma-ray sources in Fermi Large Area Telescope data...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29502588/clinical-applications-of-ultrasonic-enhancing-agents-in-echocardiography-2018-american-society-of-echocardiography-guidelines-update
#10
Thomas R Porter, Sharon L Mulvagh, Sahar S Abdelmoneim, Harald Becher, J Todd Belcik, Michelle Bierig, Jonathan Choy, Nicola Gaibazzi, Linda D Gillam, Rajesh Janardhanan, Shelby Kutty, Howard Leong-Poi, Jonathan R Lindner, Michael L Main, Wilson Mathias, Margaret M Park, Roxy Senior, Flordeliza Villanueva
No abstract text is available yet for this article.
March 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29479071/genetic-variation-in-aquaporin-4-moderates-the-relationship-between-sleep-and-brain-a%C3%AE-amyloid-burden
#11
REVIEW
Stephanie R Rainey-Smith, Gavin N Mazzucchelli, Victor L Villemagne, Belinda M Brown, Tenielle Porter, Michael Weinborn, Romola S Bucks, Lidija Milicic, Hamid R Sohrabi, Kevin Taddei, David Ames, Paul Maruff, Colin L Masters, Christopher C Rowe, Olivier Salvado, Ralph N Martins, Simon M Laws
The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of literature regarding the impact of AQP4 genetic variation on sleep, brain Aβ-amyloid burden and their relationship to each other in humans...
February 26, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29474922/electron-cryo-microscopy-structure-of-ebola-virus-nucleoprotein-reveals-a-mechanism-for-nucleocapsid-like-assembly
#12
Zhaoming Su, Chao Wu, Liuqing Shi, Priya Luthra, Grigore D Pintilie, Britney Johnson, Justin R Porter, Peng Ge, Muyuan Chen, Gai Liu, Thomas E Frederick, Jennifer M Binning, Gregory R Bowman, Z Hong Zhou, Christopher F Basler, Michael L Gross, Daisy W Leung, Wah Chiu, Gaya K Amarasinghe
Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular insights into the NC assembly process are lacking. Using a hybrid approach, we characterized the NC-like assembly of eNP, identified novel regulatory elements, and described how these elements impact function. We generated a three-dimensional structure of the eNP NC-like assembly at 5.8 Å using electron cryo-microscopy and identified a new regulatory role for eNP helices α22-α23...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29454040/development-of-an-unrelated-donor-selection-score-predictive-of-survival-after-hct-donor-age-matters-most
#13
Bronwen E Shaw, Brent R Logan, Stephen R Spellman, Steven G E Marsh, James Robinson, Joseph Pidala, Carolyn Hurley, Juliet Barker, Martin Maiers, Jason Dehn, Hailin Wang, Mike Haagenson, David Porter, Effie W Petersdorf, Ann Woolfrey, Mary M Horowitz, Michael Verneris, Katharine C Hsu, Katharina Fleischhauer, Stephanie J Lee
Donor factors, in addition to HLA matching status, have been associated with recipient survival in unrelated donor (URD) hematopoietic cell transplantation (HCT), however there is no hierarchical algorithm that weights the characteristics of individual donors against each other in a quantitative manner to facilitate donor selection. The goal of this study was to develop and validate a donor selection score that prioritizes donor characteristics associated with better survival in 8/8 HLA-matched URDs. Two separate patient/donor cohorts, the first receiving HCT between 1999-2011 (n=5952, c1), and the second between 2012-2014 (n=4510, c2) were included in the analysis...
February 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29442540/management-of-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitor-therapy-american-society-of-clinical-oncology-clinical-practice-guideline
#14
Julie R Brahmer, Christina Lacchetti, Bryan J Schneider, Michael B Atkins, Kelly J Brassil, Jeffrey M Caterino, Ian Chau, Marc S Ernstoff, Jennifer M Gardner, Pamela Ginex, Sigrun Hallmeyer, Jennifer Holter Chakrabarty, Natasha B Leighl, Jennifer S Mammen, David F McDermott, Aung Naing, Loretta J Nastoupil, Tanyanika Phillips, Laura D Porter, Igor Puzanov, Cristina A Reichner, Bianca D Santomasso, Carole Seigel, Alexander Spira, Maria E Suarez-Almazor, Yinghong Wang, Jeffrey S Weber, Jedd D Wolchok, John A Thompson
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process...
February 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29431145/johne-s-disease-a-successful-eradication-programme-in-a-dairy-goat-herd
#15
William G Gavin, Catherine A Porter, Nathan Hawkins, Michael J Schofield, John M Pollock
This retrospective analysis and report describes the successful eradication and posteradication surveillance programme for Johne's disease (Mycobacterium avium subspecies paratuberculosis (MAP)) in a closed herd of dairy goats. In 1994, MAP's presence in the goat herd was first suspected through individual annual serological screening and then subsequently confirmed through faecal culture and histopathology in 1997 when implementation of a more aggressive programme of testing and eradication of the diseased animals began...
February 3, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29424783/repeat-testing-of-low-level-hiv-1-rna-assay-performance-and-implementation-in-clinical-trials
#16
Kirsten White, Will Garner, Lilian Wei, Joseph J Eron, Lijie Zhong, Michael D Miller, Hal Martin, Andrew Plummer, Cecilia Tran-Muchowski, Kim Lindstrom, James Porter, David Piontkowsky, Angela Light, Heinz Reiske, Erin Quirk
OBJECTIVE: Assess the performance of HIV-1 RNA repeat testing of stored samples in cases of low-level viremia during clinical trials. DESIGN: Prospective and retrospective analysis of randomized clinical trial samples and reference standards. METHODS: To evaluate assay variability of the Cobas AmpliPrep/Cobas TaqMan HIV-1 Test, v2.0, three separate sources of samples were utilized: the World Health Organization (WHO) HIV reference standard (assayed using 50 independent measurements at six viral loads <200 copies/ml), retrospective analysis of four to six aliquots of plasma samples from four clinical trial participants, and prospective repeat testing of 120 samples from participants in randomized trials with low-level viremia...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29406339/implications-of-introducing-new-technology-comparative-survivorship-modeling-of-metal-on-metal-hip-replacements-and-contemporary-alternatives-in-the-national-joint-registry
#17
Linda P Hunt, Michael R Whitehouse, Andrew Beswick, Martyn L Porter, Peter Howard, Ashley W Blom
BACKGROUND: New medical technologies are often used widely without adequate supporting data, a practice that can lead to widespread catastrophic failure such as occurred with metal-on-metal (MoM) hip replacements. We determined both how revision rates would have differed if, instead of receiving MoM hip replacements, patients had received existing alternatives and the subsequent cumulative re-revision rates of the patients who did receive MoM hip replacements compared with alternatives...
February 7, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29404936/the-impact-of-bariatric-surgery-on-short-term-risk-of-clostridium-difficile-admissions
#18
Hisham Hussan, Emmanuel Ugbarugba, Michael T Bailey, Kyle Porter, Bradley Needleman, Sabrena Noria, Benjamin O'Donnell, Steven K Clinton
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) is major health care concern with reports linking it to obesity. Our aim was to investigate the little known impact of the two most common bariatric surgeries, Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), on risk of CDI admissions. METHODS: This is a retrospective cohort study using the 2013 Nationwide Readmission Database. We examined inpatient CDI rates within 120 days after RYGB (n = 40,059) and VSG (n = 45,394)...
February 5, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29378785/the-women-s-health-initiative-whi-life-and-longevity-after-cancer-lilac-study-description-and-baseline-characteristics-of-participants
#19
Electra D Paskett, Bette J Caan, Lisa Johnson, Brittany M Bernardo, Gregory S Young, Michael L Pennell, Roberta M Ray, Candyce H Kroenke, Peggy L Porter, Garnet L Anderson
Background: The Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study offers an important opportunity to advance cancer research by extending the original WHI studies to examine survivorship in women diagnosed with cancer during their participation in WHI.Methods: The goals of LILAC are to (i) obtain cancer treatment information and long-term cancer outcomes for women diagnosed with one of eight selected cancers (breast, endometrial, ovarian, lung, and colorectal cancers, and melanoma, lymphoma, and leukemia); (ii) augment the existing WHI biorepository with fixed tumor tissue from the solid tumor sites for cancers diagnosed since 2002; and (iii) develop, refine, and validate methods to use administrative data to capture treatment and recurrence data...
January 29, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29371202/complement-activation-predicts-adverse-pregnancy-outcome-in-patients-with-systemic-lupus-erythematosus-and-or-antiphospholipid-antibodies
#20
Mimi Y Kim, Marta M Guerra, Elianna Kaplowitz, Carl A Laskin, Michelle Petri, D Ware Branch, Michael D Lockshin, Lisa R Sammaritano, Joan T Merrill, T Flint Porter, Allen Sawitzke, Anne M Lynch, Jill P Buyon, Jane E Salmon
OBJECTIVE: Studies in mouse models implicate complement activation as a causative factor in adverse pregnancy outcomes (APOs). We investigated whether activation of complement early in pregnancy predicts APOs in women with systemic lupus erythematosus (SLE) and/or antiphospholipid (aPL) antibodies. METHODS: The PROMISSE Study enrolled pregnant women with SLE and/or aPL antibodies (n=487) and pregnant healthy controls (n=204) at <12 weeks gestation and evaluated them monthly...
April 2018: Annals of the Rheumatic Diseases
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