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Michael Porter

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https://www.readbyqxmd.com/read/29454040/development-of-an-unrelated-donor-selection-score-predictive-of-survival-after-hct-donor-age-matters-most
#1
Bronwen E Shaw, Brent R Logan, Stephen R Spellman, Steven G E Marsh, James Robinson, Joseph Pidala, Carolyn Hurley, Juliet Barker, Martin Maiers, Jason Dehn, Hailin Wang, Mike Haagenson, David Porter, Effie W Petersdorf, Ann Woolfrey, Mary M Horowitz, Michael Verneris, Katharine C Hsu, Katharina Fleischhauer, Stephanie J Lee
Donor factors, in addition to HLA matching status, have been associated with recipient survival in unrelated donor (URD) hematopoietic cell transplantation (HCT), however there is no hierarchical algorithm that weights the characteristics of individual donors against each other in a quantitative manner to facilitate donor selection. The goal of this study was to develop and validate a donor selection score that prioritizes donor characteristics associated with better survival in 8/8 HLA-matched URDs. Two separate patient/donor cohorts, the first receiving HCT between 1999-2011 (n=5952, c1), and the second between 2012-2014 (n=4510, c2) were included in the analysis...
February 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29442540/management-of-immune-related-adverse-events-in-patients-treated-with-immune-checkpoint-inhibitor-therapy-american-society-of-clinical-oncology-clinical-practice-guideline
#2
Julie R Brahmer, Christina Lacchetti, Bryan J Schneider, Michael B Atkins, Kelly J Brassil, Jeffrey M Caterino, Ian Chau, Marc S Ernstoff, Jennifer M Gardner, Pamela Ginex, Sigrun Hallmeyer, Jennifer Holter Chakrabarty, Natasha B Leighl, Jennifer S Mammen, David F McDermott, Aung Naing, Loretta J Nastoupil, Tanyanika Phillips, Laura D Porter, Igor Puzanov, Cristina A Reichner, Bianca D Santomasso, Carole Seigel, Alexander Spira, Maria E Suarez-Almazor, Yinghong Wang, Jeffrey S Weber, Jedd D Wolchok, John A Thompson
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint inhibitor (ICPi) therapy. Methods A multidisciplinary, multi-organizational panel of experts in medical oncology, dermatology, gastroenterology, rheumatology, pulmonology, endocrinology, urology, neurology, hematology, emergency medicine, nursing, trialist, and advocacy was convened to develop the clinical practice guideline. Guideline development involved a systematic review of the literature and an informal consensus process...
February 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29431145/johne-s-disease-a-successful-eradication-programme-in-a-dairy-goat-herd
#3
William G Gavin, Catherine A Porter, Nathan Hawkins, Michael J Schofield, John M Pollock
This retrospective analysis and report describes the successful eradication and posteradication surveillance programme for Johne's disease (Mycobacterium avium subspecies paratuberculosis (MAP)) in a closed herd of dairy goats. In 1994, MAP's presence in the goat herd was first suspected through individual annual serological screening and then subsequently confirmed through faecal culture and histopathology in 1997 when implementation of a more aggressive programme of testing and eradication of the diseased animals began...
February 3, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29424783/repeat-testing-of-low-level-hiv-1-rna-assay-performance-and-implementation-in-clinical-trials
#4
Kirsten White, Will Garner, Lilian Wei, Joseph J Eron, Lijie Zhong, Michael D Miller, Hal Martin, Andrew Plummer, Cecilia Tran-Muchowski, Kim Lindstrom, James Porter, David Piontkowsky, Angela Light, Heinz Reiske, Erin Quirk
OBJECTIVE: Assess the performance of HIV-1 RNA repeat testing of stored samples in cases of low-level viremia during clinical trials. DESIGN: Prospective and retrospective analysis of randomized clinical trial samples and reference standards. METHODS: To evaluate assay variability of the Cobas AmpliPrep/Cobas TaqMan HIV-1 Test, v2.0, three separate sources of samples were utilized: the World Health Organization (WHO) HIV reference standard (assayed using 50 independent measurements at six viral loads <200 copies/ml), retrospective analysis of four to six aliquots of plasma samples from four clinical trial participants, and prospective repeat testing of 120 samples from participants in randomized trials with low-level viremia...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29406339/implications-of-introducing-new-technology-comparative-survivorship-modeling-of-metal-on-metal-hip-replacements-and-contemporary-alternatives-in-the-national-joint-registry
#5
Linda P Hunt, Michael R Whitehouse, Andrew Beswick, Martyn L Porter, Peter Howard, Ashley W Blom
BACKGROUND: New medical technologies are often used widely without adequate supporting data, a practice that can lead to widespread catastrophic failure such as occurred with metal-on-metal (MoM) hip replacements. We determined both how revision rates would have differed if, instead of receiving MoM hip replacements, patients had received existing alternatives and the subsequent cumulative re-revision rates of the patients who did receive MoM hip replacements compared with alternatives...
February 7, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29404936/the-impact-of-bariatric-surgery-on-short-term-risk-of-clostridium-difficile-admissions
#6
Hisham Hussan, Emmanuel Ugbarugba, Michael T Bailey, Kyle Porter, Bradley Needleman, Sabrena Noria, Benjamin O'Donnell, Steven K Clinton
BACKGROUND AND AIMS: Clostridium difficile infection (CDI) is major health care concern with reports linking it to obesity. Our aim was to investigate the little known impact of the two most common bariatric surgeries, Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), on risk of CDI admissions. METHODS: This is a retrospective cohort study using the 2013 Nationwide Readmission Database. We examined inpatient CDI rates within 120 days after RYGB (n = 40,059) and VSG (n = 45,394)...
February 5, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29378785/the-women-s-health-initiative-whi-life-and-longevity-after-cancer-lilac-study-description-and-baseline-characteristics-of-participants
#7
Electra D Paskett, Bette J Caan, Lisa Johnson, Brittany M Bernardo, Gregory S Young, Michael L Pennell, Roberta M Ray, Candyce H Kroenke, Peggy L Porter, Garnet L Anderson
Background: The Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study offers an important opportunity to advance cancer research by extending the original WHI studies to examine survivorship in women diagnosed with cancer during their participation in WHI.Methods: The goals of LILAC are to (i) obtain cancer treatment information and long-term cancer outcomes for women diagnosed with one of eight selected cancers (breast, endometrial, ovarian, lung, and colorectal cancers, and melanoma, lymphoma, and leukemia); (ii) augment the existing WHI biorepository with fixed tumor tissue from the solid tumor sites for cancers diagnosed since 2002; and (iii) develop, refine, and validate methods to use administrative data to capture treatment and recurrence data...
January 29, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29371202/complement-activation-predicts-adverse-pregnancy-outcome-in-patients-with-systemic-lupus-erythematosus-and-or-antiphospholipid-antibodies
#8
Mimi Y Kim, Marta M Guerra, Elianna Kaplowitz, Carl A Laskin, Michelle Petri, D Ware Branch, Michael D Lockshin, Lisa R Sammaritano, Joan T Merrill, T Flint Porter, Allen Sawitzke, Anne M Lynch, Jill P Buyon, Jane E Salmon
OBJECTIVE: Studies in mouse models implicate complement activation as a causative factor in adverse pregnancy outcomes (APOs). We investigated whether activation of complement early in pregnancy predicts APOs in women with systemic lupus erythematosus (SLE) and/or antiphospholipid (aPL) antibodies. METHODS: The PROMISSE Study enrolled pregnant women with SLE and/or aPL antibodies (n=487) and pregnant healthy controls (n=204) at <12 weeks gestation and evaluated them monthly...
January 25, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29367080/human-igg-lacking-effector-functions-demonstrate-lower-fcrn-binding-and-reduced-transplacental-transport
#9
Nigel M Stapleton, Sylvia S Armstrong-Fisher, Jan Terje Andersen, C Ellen van der Schoot, Charlene Porter, Kenneth R Page, Donald Falconer, Masja de Haas, Lorna M Williamson, Michael R Clark, Gestur Vidarsson, Kathryn L Armour
We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI-III) and C1q, thereby eliminating their destructive effector functions (constant region G1Δnab). In their potential use as blocking agents, favorable binding to the neonatal Fc receptor (FcRn) is important to preserve the long half-life typical of IgG. An ability to cross the placenta, which is also mediated, at least in part, by FcRn is desirable in some indications, such as feto-maternal alloimmune disorders...
January 20, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29362468/corrigendum-the-ra-map-consortium-a-working-model-for-academia-industry-collaboration
#10
Andrew P Cope, Michael R Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S Goodyear, Paul Emery, Michael R Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F McDermott, Iain B McInnes, Christopher M Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulze-Knappe, Matthew A Sleeman, Deborah Symmons, Peter C Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D Isaacs
This corrects the article DOI: 10.1038/nrrheum.2017.200.
January 24, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29357404/robotic-partial-nephrectomy-for-large-renal-masses-a-multi-institutional-series
#11
Joan C Delto, David Paulucci, Michael W Helbig, Ketan K Badani, Daniel Eun, Ronney Abaza, James Porter, Ashok K Hemal, Akshay Bhandari
OBJECTIVES: To compare perioperative outcomes after RPN for cT2a (7 to <10cm) to cT1 tumors. Robotic partial nephrectomy (RPN) for T1 tumors has been shown to be safe, however, evaluation of PN for larger, complex tumors is lacking. MATERIALS AND METHODS: Patients with a cT1a (n=1358, 76.4%), cT1b (n=379, 21.3%) or cT2a (n=41, 2.3%) renal mass were identified from a multi-institutional RPN database. Intra and post-operative outcomes were compared for cT2a masses to cT1a and cT1b masses with multivariable regression models (i...
January 22, 2018: BJU International
https://www.readbyqxmd.com/read/29345197/neonatal-hyperoxia-depletes-pulmonary-vein-cardiomyocytes-in-adult-mice-via-mitochondrial-oxidation
#12
Min Yee, Ethan David Cohen, William Domm, George A Porter, Andrew N McDavid, Michael A O'Reilly
Supplemental oxygen given to preterm infants has been associated with permanently altering postnatal lung development. Now that these individuals are reaching adulthood, there is growing concern that early-life oxygen exposure may also promote cardiovascular disease through poorly understood mechanisms. We previously reported that adult mice exposed to 100% oxygen between postnatal days 0-4 develop pulmonary hypertension defined pathologically by capillary rarefaction, dilation of arterioles and veins, cardiac failure, and a reduced lifespan...
January 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29337486/improving-risk-stratification-among-veterans-diagnosed-with-prostate-cancer-impact-of-the-17-gene-prostate-score-assay
#13
Julie A Lynch, Megan P Rothney, Raoul R Salup, Cesar E Ercole, Sharad C Mathur, David A Duchene, Joseph W Basler, Javier Hernandez, Michael A Liss, Michael P Porter, Jonathan L Wright, Michael C Risk, Mark Garzotto, Olga Efimova, Laurie Barrett, Brygida Berse, Michael J Kemeter, Phillip G Febbo, Atreya Dash
BACKGROUND: Active surveillance (AS) has been widely implemented within Veterans Affairs' medical centers (VAMCs) as a standard of care for low-risk prostate cancer (PCa). Patient characteristics such as age, race, and Agent Orange (AO) exposure may influence advisability of AS in veterans. The 17-gene assay may improve risk stratification and management selection. OBJECTIVES: To compare management strategies for PCa at 6 VAMCs before and after introduction of the Oncotype DX Genomic Prostate Score (GPS) assay...
January 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29327208/analysis-of-dna-modifications-in-aging-research
#14
REVIEW
Dustin R Masser, Niran Hadad, Hunter Porter, Michael B Stout, Archana Unnikrishnan, David R Stanford, Willard M Freeman
As geroscience research extends into the role of epigenetics in aging and age-related disease, researchers are being confronted with unfamiliar molecular techniques and data analysis methods that can be difficult to integrate into their work. In this review, we focus on the analysis of DNA modifications, namely cytosine methylation and hydroxymethylation, through next-generation sequencing methods. While older techniques for modification analysis performed relative quantitation across regions of the genome or examined average genome levels, these analyses lack the desired specificity, rigor, and genomic coverage to firmly establish the nature of genomic methylation patterns and their response to aging...
January 11, 2018: GeroScience
https://www.readbyqxmd.com/read/29326426/mrna-vaccines-a-new-era-in-vaccinology
#15
REVIEW
Norbert Pardi, Michael J Hogan, Frederick W Porter, Drew Weissman
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans...
January 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29297276/ale-automated-label-extraction-from-geo-metadata
#16
Cory B Giles, Chase A Brown, Michael Ripperger, Zane Dennis, Xiavan Roopnarinesingh, Hunter Porter, Aleksandra Perz, Jonathan D Wren
BACKGROUND: NCBI's Gene Expression Omnibus (GEO) is a rich community resource containing millions of gene expression experiments from human, mouse, rat, and other model organisms. However, information about each experiment (metadata) is in the format of an open-ended, non-standardized textual description provided by the depositor. Thus, classification of experiments for meta-analysis by factors such as gender, age of the sample donor, and tissue of origin is not feasible without assigning labels to the experiments...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29275547/noninvasive-in-vivo-optical-coherence-tomography-tracking-of-chronic-otitis-media-in-pediatric-subjects-after-surgical-intervention
#17
Guillermo L Monroy, Paritosh Pande, Ryan M Nolan, Ryan L Shelton, Ryan G Porter, Michael A Novak, Darold R Spillman, Eric J Chaney, Daniel T McCormick, Stephen A Boppart
In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region) and directly adjacent middle-ear cavity were observed in vivo with a handheld OCT probe and portable system...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29241011/silver-free-palladium-catalyzed-c-sp3-h-arylation-of-saturated-bicyclic-amine-scaffolds
#18
Charlotte E Coomber, Laure Benhamou, Dejan-Krešimir Bučar, Peter D Smith, Michael J Porter, Tom David Sheppard
Herein we report a silver-free Pd(II)-catalyzed C(sp3)-H arylation of saturated bicyclic and tricyclic amine scaffolds. The reaction provides good yields using a range of aryl iodides and aryl bromides including functionalized examples bearing aldehydes, ketones, esters, free phenols and heterocycles. The methodology has been applied to medicinally relevant scaffolds. Two of the intermediate palladium complexes in the catalytic cycle have been prepared and characterized, and a mechanism proposed. Removal of the directing group proceeded with good yield under relatively mild conditions...
December 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29213124/the-ra-map-consortium-a-working-model-for-academia-industry-collaboration
#19
REVIEW
Andrew P Cope, Michael R Barnes, Alexandra Belson, Michael Binks, Sarah Brockbank, Francisco Bonachela-Capdevila, Claudio Carini, Benjamin A Fisher, Carl S Goodyear, Paul Emery, Michael R Ehrenstein, Neil Gozzard, Ray Harris, Sally Hollis, Sarah Keidel, Marc Levesque, Catharina Lindholm, Michael F McDermott, Iain B McInnes, Christopher M Mela, Gerry Parker, Simon Read, Ayako Wakatsuki Pedersen, Frederique Ponchel, Duncan Porter, Ravi Rao, Anthony Rowe, Peter Schulze-Knappe, Matthew A Sleeman, Deborah Symmons, Peter C Taylor, Brian Tom, Wayne Tsuji, Denny Verbeeck, John D Isaacs
Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of 'big data'...
December 7, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29183129/synthesis-of-4-5-diazaspiro-2-3-hexanes-and-1-2-diazaspiro-3-3-heptanes-as-hexahydropyridazine-analogues
#20
Alpa K Pancholi, Gregory P Iacobini, Guy J Clarkson, David W Porter, Michael Shipman
4,5-Diazaspiro[2.3]hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using difluorocarbene, generated from TMSCF3/NaI, these spirocycles were produced in yields up to 97% by stereospecific addition across the alkene. Lower yields (up to 64%) were observed using more reactive dichlorocarbene, due to competitive insertion of the carbene into the N-N bond. Larger 1,2-diazaspiro[3.3]heptanes are produced by [2+2] cycloaddition of 3-alkylidene-1,2-diazetidines with tetracyanoethylene (TCNE) in up to 99% yield...
November 28, 2017: Journal of Organic Chemistry
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