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Michael Porter

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https://www.readbyqxmd.com/read/28207893/career-interest-and-perceptions-of-nephrology-a-repeated-cross-sectional-survey-of-internal-medicine-residents
#1
Michael N Daniels, Sharon Maynard, Ivan Porter, Hope Kincaid, Deepika Jain, Nabeel Aslam
BACKGROUND: Interest in nephrology careers among internal medicine residents in the United States is declining. Our objective was to assess the impact of the presence of a nephrology fellowship training program on perceptions and career interest in nephrology among internal medicine residents. A secondary objective was to identify commonly endorsed negative perceptions of nephrology among internal medicine residents. METHODS: This was a repeated cross-sectional survey of internal medicine residents before (Group 1) and 3 years after (Group 2) the establishment of nephrology fellowship programs at two institutions...
2017: PloS One
https://www.readbyqxmd.com/read/28188563/how-do-kenyan-orphan-girls-experience-less-meaningful-lives-and-how-much-does-it-matter-for-health
#2
Michael L Goodman, Thomas M Johnson, Shannon Guillot-Wright, Katherine Ackerman Porter, Philip H Keiser, Stanley Gitari
BACKGROUND: Currently, 2.5 million orphaned children are living in Kenya and 56 million orphaned children are living across sub-Saharan Africa. No empirical research has investigated meaningfulness of life among this population, and few studies provide perspectives on the life-course consequences of losing a parent during childhood. METHODS: In this study, we assess life meaningfulness in cross section of Kenyan women (n = 1974) in a semi-rural area of the country (Meru County) collected during June 2015...
February 10, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28176645/prevention-interventions-for-people-living-with-hiv-in-military-settings
#3
Michael Grillo, Margo Sloan, Che Wankie, Kelly Woodland, Elizabeth Reader, Bruce Porter, Caroline Macera, Richard Shaffer
Military prevention programs and healthy living programs were developed in the mid-1980s to manage and support newly HIV-positive military personnel in the US military. Since then, a program developed by the Centers for Disease Control and Prevention with support from the Department of Defense HIV/AIDS Prevention Program (DHAPP), called Positive Health, Dignity and Prevention (PHDP), is currently being rolled out by DHAPP in partner militaries. The program, designed to reduce HIV transmission, is a package of interventions for people living with HIV (PLHIV), including risk reduction counseling, condom provision, disclosure counseling, testing of sexual partner(s) and children, adherence counseling, diagnosis and treatment of sexually transmitted infections, and provision of family planning services...
February 7, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28175413/the-barrow-randomized-operating-room-traffic-brite-trial-an-observational-study-on-the-effect-of-operating-room-traffic-on-infection-rates
#4
Michael A Bohl, Justin C Clark, Mark E Oppenlander, Kristina Chapple, Alex Budde, Ting Lei, Andrew J Meeusen, Randall W Porter, Robert F Spetzler
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173871/characterization-and-pathogenesis-of-aerosolized-eastern-equine-encephalitis-in-the-common-marmoset-callithrix-jacchus
#5
Aimee I Porter, Rebecca A Erwin-Cohen, Nancy Twenhafel, Taylor Chance, Steven B Yee, Steven J Kern, David Norwood, Laurie J Hartman, Michael D Parker, Pamela J Glass, Luis DaSilva
BACKGROUND: Licensed antiviral therapeutics and vaccines to protect against eastern equine encephalitis virus (EEEV) in humans currently do not exist. Animal models that faithfully recapitulate the clinical characteristics of human EEEV encephalitic disease, including fever, drowsiness, anorexia, and neurological signs such as seizures, are needed to satisfy requirements of the Food and Drug Administration (FDA) for clinical product licensing under the Animal Rule. METHODS: In an effort to meet this requirement, we estimated the median lethal dose and described the pathogenesis of aerosolized EEEV in the common marmoset (Callithrix jacchus)...
February 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28152947/measuring-value-in-bundled-payments-for-head-and-neck-cancer
#6
Tracy E Spinks, Alexis B Guzman, Randal S Weber, Ehab Y Hanna, Amy Clark Hessel, Beth Michelle Beadle, Kate A Hutcheson, James Incalcaterra, Nancy M Wood, Delrose Jones, Thomas W Feeley
: 11 Background: Value, defined as outcomes relative to costs, cannot be improved without rigorous long-term measurement. To assess value within a bundled payment pilot for head and neck cancer, we aim to generate timely, patient-centered outcomes and robust, near-real time financial tracking (Porter and Teisberg, Redefining health care. Creating value-based competition on results; Harvard Business School Press, 2006). METHODS: Clinical and quality experts created an outcome measure set for head and neck cancer, using a three-tiered outcomes hierarchy from Michael Porter of Harvard Business School as a framework...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28131676/3d-printing-and-mechanics-of-bio-inspired-articulated-and-multi-material-structures
#7
Michael M Porter, Nakul Ravikumar, Francois Barthelat, Roberto Martini
3D-printing technologies allow researchers to build simplified physical models of complex biological systems to more easily investigate their mechanics. In recent years, a number of 3D-printed structures inspired by the dermal armors of various fishes have been developed to study their multiple mechanical functionalities, including flexible protection, improved hydrodynamics, body support, or tail prehensility. Natural fish armors are generally classified according to their shape, material and structural properties as elasmoid scales, ganoid scales, placoid scales, carapace scutes, or bony plates...
December 21, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28124276/activated-thrombin-activatable-fibrinolysis-inhibitor-attenuates-the-angiogenic-potential-of-endothelial-cells-potential-relevance-to-the-breast-tumour-microenvironment
#8
Zainab A Bazzi, Jennifer Balun, Dora Cavallo-Medved, Lisa A Porter, Michael B Boffa
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a basic carboxypeptidase zymogen present in blood plasma. Proteolytic activation of TAFI by thrombin, thrombin in complex with the endothelial cell cofactor thrombomodulin, or plasmin results in an enzyme (TAFIa) that removes carboxyl-terminal lysine residues from protein and peptide substrates, including cell-surface plasminogen receptors. TAFIa is therefore capable of inhibiting plasminogen activation in the pericellular milieu. Since plasminogen activation has been linked to angiogenesis, TAFIa could therefore have anti-angiogenic properties, and indeed TAFIa has been shown to inhibit endothelial tube formation in a fibrin matrix...
January 25, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28118559/therapeutic-hypothermia-after-in-hospital-cardiac-arrest-in-children
#9
RANDOMIZED CONTROLLED TRIAL
Frank W Moler, Faye S Silverstein, Richard Holubkov, Beth S Slomine, James R Christensen, Vinay M Nadkarni, Kathleen L Meert, Brittan Browning, Victoria L Pemberton, Kent Page, Marianne R Gildea, Barnaby R Scholefield, Seetha Shankaran, Jamie S Hutchison, John T Berger, George Ofori-Amanfo, Christopher J L Newth, Alexis Topjian, Kimberly S Bennett, Joshua D Koch, Nga Pham, Nikhil K Chanani, Jose A Pineda, Rick Harrison, Heidi J Dalton, Jeffrey Alten, Charles L Schleien, Denise M Goodman, Jerry J Zimmerman, Utpal S Bhalala, Adam J Schwarz, Melissa B Porter, Samir Shah, Ericka L Fink, Patrick McQuillen, Theodore Wu, Sophie Skellett, Neal J Thomas, Jeffrey E Nowak, Paul B Baines, John Pappachan, Mudit Mathur, Eric Lloyd, Elise W van der Jagt, Emily L Dobyns, Michael T Meyer, Ronald C Sanders, Amy E Clark, J Michael Dean
Background Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after in-hospital cardiac arrest are limited. Methods In a trial conducted at 37 children's hospitals, we compared two temperature interventions in children who had had in-hospital cardiac arrest. Within 6 hours after the return of circulation, comatose children older than 48 hours and younger than 18 years of age were randomly assigned to therapeutic hypothermia (target temperature, 33...
26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28115167/physician-assessment-of-pre-test-probability-of-malignancy-and-adherence-with-guidelines-for-pulmonary-nodule-evaluation
#10
Nichole T Tanner, Alexander Porter, Michael Gould, Xiao-Jun Li, Anil Vachani, Gerard A Silvestri
BACKGROUND: The annual incidence of pulmonary nodules is estimated at 1.57 million. Guidelines recommend utilizing an initial assessment of nodule probability for malignancy (pCA). A previous study found that despite this recommendation, physicians did not follow guidelines. METHODS: Physician (n= 337) and two previously validated risk model assessment of cancer pre-test probability were evaluated for performance in 337 patients with pulmonary nodules based on final diagnosis and compared...
January 20, 2017: Chest
https://www.readbyqxmd.com/read/28114223/defining-the-added-value-of-99mtc-mibi-spect-ct-to-conventional-cross-sectional-imaging-in-the-characterization-of-enhancing-solid-renal-masses
#11
Sara Sheikhbahaei, Christopher S Jones, Kristin K Porter, Steven P Rowe, Michael A Gorin, Alex S Baras, Phillip M Pierorazio, Mark W Ball, Takahiro Higuchi, Pamela T Johnson, Lilja B Solnes, Jonathan I Epstein, Mohamad E Allaf, Mehrbod S Javadi
PURPOSE: This study investigates whether the addition of preoperative Tc-MIBI SPECT/CT can increase the degree of diagnostic confidence in the differentiation of benign from malignant enhancing renal masses. PATIENTS AND METHODS: Patients were recruited as part of an institutional review board-approved prospective clinical trial. Forty-eight patients with clinical stage T1 solid renal masses who underwent a Tc-MIBI SPECT/CT before partial or radical nephrectomy were evaluated...
January 20, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28111478/operating-modes-and-cooling-capabilities-of-the-3-stage-adr-developed-for-the-soft-x-ray-spectrometer-instrument-on-astro-h
#12
Peter J Shirron, Mark O Kimball, Bryan L James, Theo Muench, Michael J DiPirro, Richard V Letmate, Michael A Sampson, Tom G Bialas, Gary A Sneiderman, Frederick S Porter, Richard L Kelley
A 3-stage adiabatic demagnetization refrigerator (ADR)[1] is used on the Soft X-ray Spectrometer instrument[2] on Astro-H[3] to cool a 6×6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system[4] consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system...
March 1, 2016: Cryogenics
https://www.readbyqxmd.com/read/28111098/carbon-sources-tune-antibiotic-susceptibility-in-pseudomonas-aeruginosa-via-tricarboxylic-acid-cycle-control
#13
Sylvain Meylan, Caroline B M Porter, Jason H Yang, Peter Belenky, Arnaud Gutierrez, Michael A Lobritz, Jihye Park, Sun H Kim, Samuel M Moskowitz, James J Collins
Metabolically dormant bacteria present a critical challenge to effective antimicrobial therapy because these bacteria are genetically susceptible to antibiotic treatment but phenotypically tolerant. Such tolerance has been attributed to impaired drug uptake, which can be reversed by metabolic stimulation. Here, we evaluate the effects of central carbon metabolite stimulations on aminoglycoside sensitivity in the pathogen Pseudomonas aeruginosa. We identify fumarate as a tobramycin potentiator that activates cellular respiration and generates a proton motive force by stimulating the tricarboxylic acid (TCA) cycle...
January 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28093409/deuterater-a-tool-for-quantifying-peptide-isotope-precision-and-kinetic-proteomics
#14
Bradley C Naylor, Michael T Porter, Elise Wilson, Adam Herring, Spencer Lofthouse, Austin Hannemann, Stephen R Piccolo, Alan L Rockwood, John C Price
MOTIVATION: Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don't access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28091393/viral-blips-were-infrequent-in-treatment-naive-adults-treated-with-rilpivirine-emtricitabine-tenofovir-df-or-efavirenz-emtricitabine-tenofovir-df-through-96-weeks
#15
Danielle P Porter, Rima Kulkarni, Will Garner, Michael D Miller, Kirsten L White
BACKGROUND: The clinical impact of transient episodes of HIV viremia (viral blips) on virologic failure and resistance development is not fully understood. Here we investigated the blip frequency and virologic outcomes of HIV-1-infected subjects experiencing viral blips among treatment-naïve subjects initiating therapy on rilpivirine (RPV)/emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) or efavirenz (EFV)/FTC/TDF through 96 weeks of treatment. METHODS: Subjects treated with at least one dose of study drug and with at least one post-baseline HIV-1 RNA value were included in this analysis...
January 16, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28089802/incorporating-formal-nutrition-education-into-a-medical-school-curriculum-a-student-initiated-lecture-series
#16
EDITORIAL
Vanessa Baute, Amelia D Carr, Jacob N Blackwell, Elizabeth R Carstensen, Poorvi Chhabra, Michael S Cartwright, Lindsay C Porter
No abstract text is available yet for this article.
January 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28062676/associations-of-conventional-echocardiographic-measures-with-incident-heart-failure-and-mortality-the-chronic-renal-insufficiency-cohort
#17
Ruth F Dubin, Rajat Deo, Nisha Bansal, Amanda H Anderson, Peter Yang, Alan S Go, Martin Keane, Ray Townsend, Anna Porter, Matthew Budoff, Shaista Malik, Jiang He, Mahboob Rahman, Jackson Wright, Thomas Cappola, Radhakrishna Kallem, Jason Roy, Daohang Sha, Michael G Shlipak
BACKGROUND AND OBJECTIVES: Heart failure is the most frequent cardiac complication of CKD. Left ventricular hypertrophy is common and develops early in CKD, but studies have not adequately evaluated the association of left ventricular mass index with heart failure incidence among men and women with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated echocardiograms of 2567 participants without self-reported heart failure enrolled in the Chronic Renal Insufficiency Cohort Study...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28062464/extraintestinal-pathogenic-and-antimicrobial-resistant-escherichia-coli-including-sequence-type-131-st131-from-retail-chicken-breasts-united-states-2013
#18
James R Johnson, Stephen B Porter, Brian Johnston, Paul Thuras, Sarah Clock, Michael Crupain, Urvashi Rangan
: Chicken meat products are hypothesized to be vehicles for transmitting antimicrobial-resistant and extraintestinal pathogenic Escherichia coli (ExPEC) to consumers. To reassess this hypothesis in the current era of heightened concerns about food animal antimicrobial use, we analyzed 175 chicken-source E. coli isolates from a 2013 Consumer Reports national survey. Isolates were PCR-screened for ExPEC-defining virulence genes. The 25 ExPEC isolates (12% of 175) and a 2:1 randomly selected set of 50 non-ExPEC isolates were assessed for phylogenetic/clonal background and virulence genotypes, for comparison with resistance profiles and label claims ("organic", "no antibiotics", and "natural")...
January 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28042904/the-polyanalgesic-consensus-conference-pacc-recommendations-on-intrathecal-drug-infusion-systems-best-practices-and-guidelines
#19
REVIEW
Timothy R Deer, Jason E Pope, Salim M Hayek, Anjum Bux, Eric Buchser, Sam Eldabe, Jose A De Andrés, Michael Erdek, Dennis Patin, Jay S Grider, Daniel M Doleys, Marilyn S Jacobs, Tony L Yaksh, Lawrence Poree, Mark S Wallace, Joshua Prager, Richard Rauck, Oscar DeLeon, Sudhir Diwan, Steven M Falowski, Helena M Gazelka, Philip Kim, Michael Leong, Robert M Levy, Gladstone McDowell Ii, Porter McRoberts, Ramana Naidu, Samir Narouze, Christophe Perruchoud, Steven M Rosen, William S Rosenberg, Michael Saulino, Peter Staats, Lisa J Stearns, Dean Willis, Elliot Krames, Marc Huntoon, Nagy Mekhail
INTRODUCTION: Pain treatment is best performed when a patient-centric, safety-based philosophy is used to determine an algorithmic process to guide care. Since 2007, the International Neuromodulation Society has organized a group of experts to evaluate evidence and create a Polyanalgesic Consensus Conference (PACC) to guide practice. METHODS: The current PACC update was designed to address the deficiencies and innovations emerging since the previous PACC publication of 2012...
January 2, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28030470/dorsal-root-ganglion-stimulation-yielded-higher-treatment-success-rate-for-crps-and-causalgia-at-3-and-12-months-randomized-comparative-trial
#20
Timothy R Deer, Robert M Levy, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Christopher Kim, Jason Pope, Thomas Yearwood, Sam Samuel, W Porter McRoberts, Hazmer Cassim, Mark Netherton, Nathan Miller, Michael Schaufele, Edward Tavel, Timothy Davis, Kristina Davis, Linda Johnson, Nagy Mekhail
Animal and human studies indicate that electrical stimulation of DRG neurons may modulate neuropathic pain signals.ACCURATE, a pivotal, prospective, multi-center, randomized-comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome (CRPS) or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (SCS). The primary endpoint was a composite of safety and efficacy at 3 months and subjects were assessed through 12 months for long term outcomes and adverse events...
December 23, 2016: Pain
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