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Michael Porter

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https://www.readbyqxmd.com/read/28093409/deuterater-a-tool-for-quantifying-peptide-isotope-precision-and-kinetic-proteomics
#1
Bradley C Naylor, Michael T Porter, Elise Wilson, Adam Herring, Spencer Lofthouse, Austin Hannemann, Stephen R Piccolo, Alan L Rockwood, John C Price
MOTIVATION: Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don't access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28091393/viral-blips-were-infrequent-in-treatment-naive-adults-treated-with-rilpivirine-emtricitabine-tenofovir-df-or-efavirenz-emtricitabine-tenofovir-df-through-96-weeks
#2
Danielle P Porter, Rima Kulkarni, Will Garner, Michael D Miller, Kirsten L White
BACKGROUND: The clinical impact of transient episodes of HIV viremia (viral blips) on virologic failure and resistance development is not fully understood. Here we investigated the blip frequency and virologic outcomes of HIV-1-infected subjects experiencing viral blips among treatment-naïve subjects initiating therapy on rilpivirine (RPV)/emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) or efavirenz (EFV)/FTC/TDF through 96 weeks of treatment. METHODS: Subjects treated with at least one dose of study drug and with at least one post-baseline HIV-1 RNA value were included in this analysis...
January 16, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28089802/incorporating-formal-nutrition-education-into-a-medical-school-curriculum-a-student-initiated-lecture-series
#3
EDITORIAL
Vanessa Baute, Amelia D Carr, Jacob N Blackwell, Elizabeth R Carstensen, Poorvi Chhabra, Michael S Cartwright, Lindsay C Porter
No abstract text is available yet for this article.
January 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28062676/associations-of-conventional-echocardiographic-measures-with-incident-heart-failure-and-mortality-the-chronic-renal-insufficiency-cohort
#4
Ruth F Dubin, Rajat Deo, Nisha Bansal, Amanda H Anderson, Peter Yang, Alan S Go, Martin Keane, Ray Townsend, Anna Porter, Matthew Budoff, Shaista Malik, Jiang He, Mahboob Rahman, Jackson Wright, Thomas Cappola, Radhakrishna Kallem, Jason Roy, Daohang Sha, Michael G Shlipak
BACKGROUND AND OBJECTIVES: Heart failure is the most frequent cardiac complication of CKD. Left ventricular hypertrophy is common and develops early in CKD, but studies have not adequately evaluated the association of left ventricular mass index with heart failure incidence among men and women with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We evaluated echocardiograms of 2567 participants without self-reported heart failure enrolled in the Chronic Renal Insufficiency Cohort Study...
January 6, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28062464/extraintestinal-pathogenic-and-antimicrobial-resistant-escherichia-coli-including-sequence-type-131-st131-from-retail-chicken-breasts-united-states-2013
#5
James R Johnson, Stephen B Porter, Brian Johnston, Paul Thuras, Sarah Clock, Michael Crupain, Urvashi Rangan
: Chicken meat products are hypothesized to be vehicles for transmitting antimicrobial-resistant and extraintestinal pathogenic Escherichia coli (ExPEC) to consumers. To reassess this hypothesis in the current era of heightened concerns about food animal antimicrobial use, we analyzed 175 chicken-source E. coli isolates from a 2013 Consumer Reports national survey. Isolates were PCR-screened for ExPEC-defining virulence genes. The 25 ExPEC isolates (12% of 175) and a 2:1 randomly selected set of 50 non-ExPEC isolates were assessed for phylogenetic/clonal background and virulence genotypes, for comparison with resistance profiles and label claims ("organic", "no antibiotics", and "natural")...
January 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28042904/the-polyanalgesic-consensus-conference-pacc-recommendations-on-intrathecal-drug-infusion-systems-best-practices-and-guidelines
#6
REVIEW
Timothy R Deer, Jason E Pope, Salim Hayek, Anjum Bux, Eric Buchser, Sam Eldabe, Jose A De Andrés, Michael Erdek, Dennis Patin, Jay S Grider, Daniel M Doleys, Marilyn S Jacobs, Tony L Yaksh, Lawrence Poree, Mark S Wallace, Joshua Prager, Richard Rauck, Oscar DeLeon, Sudhir Diwan, Steven M Falowski, Helena M Gazelka, Philip Kim, Michael Leong, Robert M Levy, Gladstone McDowell Ii, Porter McRoberts, Ramana Naidu, Samir Narouze, Christophe Perruchoud, Steven M Rosen, William S Rosenberg, Michael Saulino, Peter Staats, Lisa J Stearns, Dean Willis, Elliot Krames, Marc Huntoon, Nagy Mekhail
INTRODUCTION: Pain treatment is best performed when a patient-centric, safety-based philosophy is used to determine an algorithmic process to guide care. Since 2007, the International Neuromodulation Society has organized a group of experts to evaluate evidence and create a Polyanalgesic Consensus Conference (PACC) to guide practice. METHODS: The current PACC update was designed to address the deficiencies and innovations emerging since the previous PACC publication of 2012...
January 2, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28030470/dorsal-root-ganglion-stimulation-yielded-higher-treatment-success-rate-for-crps-and-causalgia-at-3-and-12-months-randomized-comparative-trial
#7
Timothy R Deer, Robert M Levy, Jeffrey Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Christopher Kim, Jason Pope, Thomas Yearwood, Sam Samuel, W Porter McRoberts, Hazmer Cassim, Mark Netherton, Nathan Miller, Michael Schaufele, Edward Tavel, Timothy Davis, Kristina Davis, Linda Johnson, Nagy Mekhail
Animal and human studies indicate that electrical stimulation of DRG neurons may modulate neuropathic pain signals.ACCURATE, a pivotal, prospective, multi-center, randomized-comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome (CRPS) or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (SCS). The primary endpoint was a composite of safety and efficacy at 3 months and subjects were assessed through 12 months for long term outcomes and adverse events...
December 23, 2016: Pain
https://www.readbyqxmd.com/read/28018601/the-society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-hematologic-malignancies-multiple-myeloma-lymphoma-and-acute-leukemia
#8
Michael Boyiadzis, Michael R Bishop, Rafat Abonour, Kenneth C Anderson, Stephen M Ansell, David Avigan, Lisa Barbarotta, Austin John Barrett, Koen Van Besien, P Leif Bergsagel, Ivan Borrello, Joshua Brody, Jill Brufsky, Mitchell Cairo, Ajai Chari, Adam Cohen, Jorge Cortes, Stephen J Forman, Jonathan W Friedberg, Ephraim J Fuchs, Steven D Gore, Sundar Jagannath, Brad S Kahl, Justin Kline, James N Kochenderfer, Larry W Kwak, Ronald Levy, Marcos de Lima, Mark R Litzow, Anuj Mahindra, Jeffrey Miller, Nikhil C Munshi, Robert Z Orlowski, John M Pagel, David L Porter, Stephen J Russell, Karl Schwartz, Margaret A Shipp, David Siegel, Richard M Stone, Martin S Tallman, John M Timmerman, Frits Van Rhee, Edmund K Waller, Ann Welsh, Michael Werner, Peter H Wiernik, Madhav V Dhodapkar
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27998549/patient-hand-off-initiation-and-evaluation-phone-study-a-randomized-trial-of-patient-handoff-methods
#9
Jesse Clanton, Aimee Gardner, Michael Subichin, Patrick McAlvanah, William Hardy, Amar Shah, Joel Porter
BACKGROUND: As residency work hour restrictions have tightened, transitions of care have become more frequent. Many institutions dedicate significant time and resources to patient handoffs despite the fact that the ideal method is relatively unknown. We sought to compare the effect of a rigorous formal handoff approach to a minimized but focused handoff process on patient outcomes. METHODS: A randomized prospective trial was conducted at a large teaching hospital over ten months...
November 23, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27998001/knocked-by-the-shuttlecock-twelve-sight-threatening-blunt-eye-injuries-in-australian-badminton-players
#10
Kathy K Jao, Alp Atik, Michael P Jamieson, Mariana P Sheales, Matthew H Lee, Ashley Porter, Athena Roufas, Ivan Goldberg, Ehud Zamir, Andrew White, Simon E Skalicky
BACKGROUND: Non-penetrating ocular injuries from badminton shuttlecocks can result in severe damage and life-long complications. This case series highlights the morbidity of such injuries, particularly in regard to post-traumatic glaucoma. METHODS: This is a retrospective case series of 12 patients with shuttlecock-related blunt eye injuries sustained during badminton play without eye protection. By approaching colleagues through conference presentations and networking, the authors have attempted to gather all known cases of shuttlecock ocular injury managed in tertiary ocular emergency departments or private ophthalmological clinics in Victoria and New South Wales, Australia in 2015...
December 20, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27935676/calibrant-free-analyte-quantitation-via-a-variable-velocity-flow-cell
#11
Jason G Beck, Aleksander Skuratovsky, Michael C Granger, Marc D Porter
In this paper, we describe a novel method for analyte quantitation that does not rely on calibrants, internal standards, or calibration curves but, rather, leverages the relationship between disparate and predictable surface-directed analyte flux to an array of sensing addresses and a measured resultant signal. To reduce this concept to practice, we fabricated two flow cells such that the mean linear fluid velocity, U, was varied systematically over an array of electrodes positioned along the flow axis. This resulted in a predictable variation of the address-directed flux of a redox analyte, ferrocenedimethanol (FDM)...
December 28, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27930279/use-of-a-novel-accounting-and-grouping-method-for-major-trunk-injuryanalysis-of-data-from-a-statewide-trauma-financial-survey
#12
Kyla D Joubert, Charles D Mabry, Kyle J Kalkwarf, Richard D Betzold, Horace J Spencer, Kara M Spinks, Austin Porter, Saleema Karim, Ronald D Robertson, Michael J Sutherland, Robert T Maxson
Major trunk trauma is common and costly, but comparisons of costs between trauma centers (TCs) are rare. Understanding cost is essential to improve quality, manage trauma service lines, and to facilitate institutional commitment for trauma. We have used results of a statewide trauma financial survey of Levels I to IV TC to develop a useful grouping method for costs and clinical characteristics of major trunk trauma. The trauma financial survey collected billing and clinical data on 75 per cent of the state trauma registry patients for fiscal year 2012...
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27919184/role-of-engineered-metal-oxide-nanoparticle-agglomeration-in-reactive-oxygen-species-generation-and-cathepsin-b-release-in-nlrp3-inflammasome-activation-and-pulmonary-toxicity
#13
Tina M Sager, Michael Wolfarth, Stephen S Leonard, Anna M Morris, Dale W Porter, Vincent Castranova, Andrij Holian
Incomplete understanding of the contributions of dispersants and engineered nanoparticles/materials (ENM) agglomeration state to biological outcomes presents an obstacle for toxicological studies. Although reactive oxygen species (ROS) production is often regarded as the primary indicator of ENM bioactivity and toxicity, it remains unclear whether ENM produce ROS or whether ROS is an outcome of ENM-induced cell injury. Phagolysosomal disruption and cathepsin B release also promote bioactivity through inflammasome activation...
December 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27880762/unexpected-diversity-in-socially-synchronized-rhythms-of-shorebirds
#14
Martin Bulla, Mihai Valcu, Adriaan M Dokter, Alexei G Dondua, András Kosztolányi, Anne L Rutten, Barbara Helm, Brett K Sandercock, Bruce Casler, Bruno J Ens, Caleb S Spiegel, Chris J Hassell, Clemens Küpper, Clive Minton, Daniel Burgas, David B Lank, David C Payer, Egor Y Loktionov, Erica Nol, Eunbi Kwon, Fletcher Smith, H River Gates, Hana Vitnerová, Hanna Prüter, James A Johnson, James J H St Clair, Jean-François Lamarre, Jennie Rausch, Jeroen Reneerkens, Jesse R Conklin, Joanna Burger, Joe Liebezeit, Joël Bêty, Jonathan T Coleman, Jordi Figuerola, Jos C E W Hooijmeijer, José A Alves, Joseph A M Smith, Karel Weidinger, Kari Koivula, Ken Gosbell, Klaus-Michael Exo, Larry Niles, Laura Koloski, Laura McKinnon, Libor Praus, Marcel Klaassen, Marie-Andrée Giroux, Martin Sládeček, Megan L Boldenow, Michael I Goldstein, Miroslav Šálek, Nathan Senner, Nelli Rönkä, Nicolas Lecomte, Olivier Gilg, Orsolya Vincze, Oscar W Johnson, Paul A Smith, Paul F Woodard, Pavel S Tomkovich, Phil F Battley, Rebecca Bentzen, Richard B Lanctot, Ron Porter, Sarah T Saalfeld, Scott Freeman, Stephen C Brown, Stephen Yezerinac, Tamás Székely, Tomás Montalvo, Theunis Piersma, Vanessa Loverti, Veli-Matti Pakanen, Wim Tijsen, Bart Kempenaers
The behavioural rhythms of organisms are thought to be under strong selection, influenced by the rhythmicity of the environment. Such behavioural rhythms are well studied in isolated individuals under laboratory conditions, but free-living individuals have to temporally synchronize their activities with those of others, including potential mates, competitors, prey and predators. Individuals can temporally segregate their daily activities (for example, prey avoiding predators, subordinates avoiding dominants) or synchronize their activities (for example, group foraging, communal defence, pairs reproducing or caring for offspring)...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27860512/color-change-for-thermoregulation-versus-camouflage-in-free-ranging-lizards
#15
Kathleen R Smith, Viviana Cadena, John A Endler, Michael R Kearney, Warren P Porter, Devi Stuart-Fox
Animal coloration has multiple functions including thermoregulation, camouflage, and social signaling, and the requirements of each function may sometimes conflict. Many terrestrial ectotherms accommodate the multiple functions of color through color change. However, the relative importance of these functions and how color-changing species accommodate them when they do conflict are poorly understood because we lack data on color change in the wild. Here, we show that the color of individual radio-tracked bearded dragon lizards, Pogona vitticeps, correlates strongly with background color and less strongly, but significantly, with temperature...
December 2016: American Naturalist
https://www.readbyqxmd.com/read/27829394/the-scottish-early-rheumatoid-arthritis-sera-study-an-inception-cohort-and-biobank
#16
James Dale, Caron Paterson, Ann Tierney, Stuart H Ralston, David M Reid, Neil Basu, John Harvie, Neil D McKay, Sarah Saunders, Hilary Wilson, Robin Munro, Ruth Richmond, Derek Baxter, Michael McMahon, John McLaren, Vinod Kumar, Stefan Siebert, Iain McInnes, Duncan Porter
The Scottish Early Rheumatoid Arthritis (SERA) study is an inception cohort of rheumatoid (RA) and undifferentiated arthritis (UA) patients that aims to provide a contemporary description of phenotype and outcome and facilitate discovery of phenotypic and prognostic biomarkers METHODS: Demographic and clinical outcome data are collected from newly diagnosed RA/UA patients every 6 months from around Scotland. Health service utilization data is acquired from Information Services Division, NHS National Services Scotland...
November 9, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27769897/evaluating-a-novel-health-system-intervention-for-chronic-kidney-disease-care-using-the-re-aim-framework-insights-after-two-years
#17
Denise M Hynes, Michael J Fischer, Linda A Schiffer, Rani Gallardo, Ifeanyi Beverly Chukwudozie, Anna Porter, Michael Berbaum, Jennifer Earheart, Marian L Fitzgibbon
INTRODUCTION: Using a quasi-experimental design, we implemented the Patient-Centered Medical Home for Kidney Disease (PCMH-KD), a comprehensive, multidisciplinary care team to improve quality of life and healthcare coordination for adult chronic hemodialysis (CHD) patients. This paper highlights our experience in the first two years of the study. We focus on the process dimensions of Reach, Adoption, and Implementation within the context of the RE-AIM framework. MATERIALS AND METHODS: We established a new PCMH-KD model at two outpatient dialysis centers...
January 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27765666/safety-efficacy-and-pharmacokinetics-of-a-single-tablet-regimen-containing-elvitegravir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-treatment-naive-hiv-infected-adolescents-a-single-arm-open-label-trial
#18
Aditya H Gaur, Hilda Kizito, Wasana Prasitsueubsai, Natella Rakhmanina, Mohammed Rassool, Rana Chakraborty, Jagmohan Batra, Pope Kosalaraksa, Wicharn Luesomboon, Danielle Porter, Yongwu Shao, Michael Myers, Lillian Ting, Devi SenGupta, Erin Quirk, Martin S Rhee
BACKGROUND: The prodrug tenofovir alafenamide is associated with improved renal and bone safety compared with tenofovir disoproxil fumarate. We aimed to assess safety, pharmacokinetics, and efficacy of this single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in HIV-infected, treatment-naive adolescents. METHODS: We did a 48 week, single-arm, open-label trial in treatment-naive adolescents with HIV from ten hospital clinics in South Africa, Thailand, Uganda, and the USA...
December 2016: Lancet HIV
https://www.readbyqxmd.com/read/27711145/interaction-of-staphylococci-with-human-b-cells
#19
Tyler K Nygaard, Scott D Kobayashi, Brett Freedman, Adeline R Porter, Jovanka M Voyich, Michael Otto, Olaf Schneewind, Frank R DeLeo
Staphylococcus aureus is a leading cause of human infections worldwide. The pathogen produces numerous molecules that can interfere with recognition and binding by host innate immune cells, an initial step required for the ingestion and subsequent destruction of microbes by phagocytes. To better understand the interaction of this pathogen with human immune cells, we compared the association of S. aureus and S. epidermidis with leukocytes in human blood. We found that a significantly greater proportion of B cells associated with S...
2016: PloS One
https://www.readbyqxmd.com/read/27703993/household-clustering-of-escherichia-coli-sequence-type-131-clinical-and-fecal-isolates-according-to-whole-genome-sequence-analysis
#20
James R Johnson, Gregg Davis, Connie Clabots, Brian D Johnston, Stephen Porter, Chitrita DebRoy, William Pomputius, Peter T Ender, Michael Cooperstock, Billie Savvas Slater, Ritu Banerjee, Sybille Miller, Dagmara Kisiela, Evgeni V Sokurenko, Maliha Aziz, Lance B Price
Background.  Within-household sharing of strains from the resistance-associated H30R1 and H30Rx subclones of Escherichia coli sequence type 131 (ST131) has been inferred based on conventional typing data, but it has been assessed minimally using whole genome sequence (WGS) analysis. Methods.  Thirty-three clinical and fecal isolates of ST131-H30R1 and ST131-H30Rx, from 20 humans and pets in 6 households, underwent WGS analysis for comparison with 52 published ST131 genomes. Phylogenetic relationships were inferred using a bootstrapped maximum likelihood tree based on core genome sequence polymorphisms...
September 2016: Open Forum Infectious Diseases
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