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https://www.readbyqxmd.com/read/29693719/smectite-for-acute-infectious-diarrhoea-in-children
#1
REVIEW
Giordano Pérez-Gaxiola, Carlos A Cuello-García, Ivan D Florez, Víctor M Pérez-Pico
BACKGROUND: As mortality secondary to acute infectious diarrhoea has decreased worldwide, the focus shifts to adjuvant therapies to lessen the burden of disease. Smectite, a medicinal clay, could offer a complementary intervention to reduce the duration of diarrhoea. OBJECTIVES: To assess the effects of smectite for treating acute infectious diarrhoea in children. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Pubmed), Embase (Ovid), LILACS, reference lists from studies and previous reviews, and conference abstracts, up to 27 June 2017...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29693574/liver-transplantation-and-gut-microbiota-profiling-in-a-child-colonized-by-a-multi-drug-resistant-klebsiella-pneumoniae-a-new-approach-to-move-from-antibiotic-to-eubiotic-control-of-microbial-resistance
#2
Federica Del Chierico, Sabrina Cardile, Andrea Pietrobattista, Daniela Liccardo, Alessandra Russo, Manila Candusso, Maria Sole Basso, Chiara Grimaldi, Laura Pansani, Paola Bernaschi, Giuliano Torre, Lorenza Putignani
The increase of microorganisms multi-drug resistant (MDR) to antibiotics (ATBs) is becoming a global emergency, especially in frail subjects. In chronic liver disease (LD) with indications for liver transplantation (LT), MDR colonization can significantly affect the LT outcome. However, no clear guidelines for microbial management are available. A novel approach toward MDR-colonized patients undergoing LT was developed at our Center refraining from ATBs use during the transplant waiting list, and use of an intensive perioperative prophylaxis cycle...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29692947/implementation-of-a-mobile-clinical-decision-support-application-to-augment-local-antimicrobial-stewardship
#3
Brian M Hoff, Diana C Ford, Dilek Ince, Erika J Ernst, Daniel J Livorsi, Brett H Heintz, Vincent Masse, Michael J Brownlee, Bradley A Ford
Background: Medical applications for mobile devices allow clinicians to leverage microbiological data and standardized guidelines to treat patients with infectious diseases. We report the implementation of a mobile clinical decision support (CDS) application to augment local antimicrobial stewardship. Methods: We detail the implementation of our mobile CDS application over 20 months. Application utilization data were collected and evaluated using descriptive statistics to quantify the impact of our implementation...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29692850/rapid-bone-healing-after-intentional-replantation-of-a-molar-with-apical-actinomycosis
#4
Saeed Asgary, Leyla Roghanizadeh
Actinomycosis is a rare lesion of the jaws and may present as periapical pathosis; therefore, it is essential to be correctly diagnosed and managed. This case presentation describes management of a tooth with a symptomatic apical periodontitis caused by Actinomyces species supplemented with medicine prescription. A woman was referred for endodontic management of tooth #19. The tooth had a history of previous nonsurgical endodontic retreatment. Clinically, the tooth was very sensitive to percussion. Radiographic evaluation showed a large periapical lesion...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29692621/h3africa-current-perspectives
#5
REVIEW
Nicola Mulder, Alash'le Abimiku, Sally N Adebamowo, Jantina de Vries, Alice Matimba, Paul Olowoyo, Michele Ramsay, Michelle Skelton, Dan J Stein
Precision medicine is being enabled in high-income countries by the growing availability of health data, increasing knowledge of the genetic determinants of disease and variation in response to treatment (pharmacogenomics), and the decreasing costs of data generation, which promote routine application of genomic technologies in the health sector. However, there is uncertainty about the feasibility of applying precision medicine approaches in low- and middle-income countries, due to the lack of population-specific knowledge, skills, and resources...
2018: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/29692328/infectious-sacroiliitis-retrospective-analysis-of-18-case-patients
#6
M Matt, E Denes, P Weinbreck
INTRODUCTION: Few infectious sacroiliitis reports are available in the literature. There is no standard clinical presentation, and diagnosis and treatments are therefore usually delayed. We aimed to describe this infection. METHODS: We performed a single-center retrospective study of patients hospitalized in the infectious diseases unit of the Limoges University Hospital from January 1, 2006 to January 31, 2016. We included all patients presenting with infectious monoarthritis of native sacroiliac joint...
April 21, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29691993/epidemiology-and-molecular-characterization-of-chicken-anaemia-virus-from-commercial-and-native-chickens-in-taiwan
#7
S-C Ou, H-L Lin, P-C Liu, H-J Huang, M-S Lee, Y-Y Lien, Y-L Tsai
Chicken infectious anaemia (CIA) is a disease with a highly economic impact in the poultry industry. The infected chickens are characterized by aplastic anaemia and extreme immunosuppression, followed by the increased susceptibility to secondary infectious pathogens and suboptimal immune responses for vaccination. Commercially available CIA vaccines are routinely used in the breeders in Taiwan to protect their progeny with maternal-derived antibodies. However, CIA cases still occur in the field and little is known about the genetic characteristics of Taiwanese chicken anaemia viruses (CAVs)...
April 25, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29691854/necropsy-findings-of-koalas-from-the-mount-lofty-ranges-population-in-south-australia
#8
K N Speight, P Hicks, C Graham, W Boardman, W G Breed, E Manthorpe, O Funnell, L Woolford
OBJECTIVE: This study reports necropsy findings of koalas from the Mount Lofty Ranges region in order to identify health threats to this mainland South Australian population. METHODS: Koalas from the Mount Lofty Ranges region (n = 85) that had died or been euthanased on welfare grounds were examined at necropsy during 2012-13 at the School of Animal and Veterinary Sciences, University of Adelaide. Disease findings, approximate age, sex and body condition of koalas were recorded...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691681/the-impact-of-the-ryan-white-hiv-aids-medical-case-management-program-on-hiv-clinical-outcomes-a-longitudinal-study
#9
Julia D López, Enbal Shacham, Tawnya Brown
Medical case management (MCM) is a core medical service in The Ryan White HIV/AIDS Program and aims to provide treatment and care for people living with HIV/AIDS by engaging, identifying and eliminating barriers to HIV care. Little research has examined the impact of this intervention; therefore, the purpose of this study was to examine the how MCM affects HIV clinical outcomes. The study took place at a midwestern, outpatient infectious diseases clinic. This study utilized a longitudinal, retrospective study design to analyze to the impact of MCM engagement on HIV clinical outcomes (viral loads, CD4 counts) from 2009 to 2015 as a time-varying predictor...
April 24, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29691631/lovastatin-synergizes-with-itraconazole-against-planktonic-cells-and-biofilms-of-candida-albicans-through-the-regulation-on-ergosterol-biosynthesis-pathway
#10
Yujie Zhou, Hong Yang, Xuedong Zhou, Hongke Luo, Fan Tang, Jin Yang, Gil Alterovitz, Lei Cheng, Biao Ren
The increase of fungal infectious diseases and lack of safe and efficacious antifungal drugs result in the urgent need of new therapeutic strategies. Here, we repurposed the lovastatin (LOV) as a synergistic antifungal potentiator to itraconazole (ITZ) against Candida albicans planktonic cells and biofilms in vitro for the first time. Mutants from ergosterol biosynthesis pathway were employed and key gene expression profiles of ergosterol pathway were also measured. LOV single treatment was unable to inhibit C...
April 25, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29690900/neglected-aspects-of-tick-borne-rickettsioses
#11
REVIEW
Laura Tomassone, Aránzazu Portillo, Markéta Nováková, Rita de Sousa, José Antonio Oteo
Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered...
April 24, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29688817/current-status-of-messenger-rna-delivery-systems
#12
Matthew G Stanton
Messenger RNA is emerging as a highly versatile biological construct for creation of impactful medicines. mRNA vaccines directed toward infectious disease and cancer are in clinical development with encouraging early reads on tolerability and efficacy. The use of mRNA to direct intense but transient expression of paracrine factors is finding utility in reprogramming progenitor cells for wound healing and cardiac regeneration and for stimulation of antitumor immune responses, at least preclinically as we await clinical results...
April 24, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29688800/missed-opportunities-to-prescribe-hiv-pre-exposure-prophylaxis-by-primary-care-providers-in-saint-louis-missouri
#13
Rupa R Patel, Philip A Chan, Laura C Harrison, Kenneth H Mayer, Amy Nunn, Leandro A Mena, William G Powderly
PURPOSE: Optimal HIV pre-exposure prophylaxis (PrEP) scale-up in the United States requires prescribing by primary care providers (PCPs). We assessed barriers to patients obtaining PrEP from their PCPs. METHODS: Patients seeking PrEP at an Infectious Diseases (ID) Clinic in St. Louis, Missouri from 2014 to 2016 were asked about demographics, sexual behaviors, whether PrEP was initially sought from their PCP, and barriers to obtaining PrEP from their PCP. Multivariable logistic regression was performed to identify predictors for having asked a PCP for PrEP...
April 24, 2018: LGBT Health
https://www.readbyqxmd.com/read/29688266/anti-infective-vaccination-strategies-in-patients-with-hematologic-malignancies-or-solid-tumors-guideline-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-hematology-and-medical-oncology-dgho
#14
C T Rieger, B Liss, S Mellinghoff, D Buchheidt, O A Cornely, G Egerer, W J Heinz, M Hentrich, G Maschmeyer, K Mayer, M Sandherr, G Silling, A Ullmann, M J G T Vehreschild, M von Lilienfeld-Toal, H H Wolf, N Lehners
Infectious complications are a significant cause of morbidity and mortality in patients with malignancies specifically when receiving anticancer treatments. Prevention of infection through vaccines is an important aspect of clinical care of cancer patients. Immunocompromising effects of the underlying disease as well as of antineoplastic therapies need to be considered when devising vaccination strategies. This guideline provides clinical recommendations on vaccine use in cancer patients including autologous stem cell transplant recipients, while allogeneic stem cell transplantation is subject of a separate guideline...
April 24, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29687035/pharmacology-of-recombinant-adeno-associated-virus-production
#15
REVIEW
Magalie Penaud-Budloo, Achille François, Nathalie Clément, Eduard Ayuso
Recombinant adeno-associated viral (rAAV) vectors have been used in more than 150 clinical trials with a good safety profile and significant clinical benefit in many genetic diseases. In addition, due to their ability to infect non-dividing and dividing cells and to serve as efficient substrate for homologous recombination, rAAVs are being used as a tool for gene-editing approaches. However, manufacturing of these vectors at high quantities and fulfilling current good manufacturing practices (GMP) is still a challenge, and several technological platforms are competing for this niche...
March 16, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29686785/primary-thyroid-maltoma-a-rare-diagnosis-of-an-unassuming-thyroid-nodule
#16
Pragya Shrestha, Kimberly Aderhold, Sharon Swierczynski, Catherine Lin, Ronald Herb
Primary thyroid lymphoma, although a rare malignancy, can arise in common chronic inflammatory conditions such as Hashimoto's thyroiditis. Incidental finding of a thyroid nodule with chronic thyroid inflammation warrants further investigation. Early detection of malignancy can play a vital role in improved outcomes. We report a case of a 60-year-old male who presented to the clinic for a routine visit. An enlarged, firm, non-tender thyroid gland was appreciated on exam with high thyroid stimulating hormone (TSH) level...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29686661/molecular-imaging-of-invasive-pulmonary-aspergillosis-using-immunopet-mri-the-future-looks-bright
#17
REVIEW
Christopher R Thornton
Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mold Aspergillus . Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision making, and so is used in many hematology units to drive antifungal treatment...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29685413/a-cavernous-sinus-lesion-clinically-responsive-to-steroids
#18
M W Ruff, I D Carabenciov, D R Johnson, B E Pollock, J E Parisi, J P Klaas
Tolosa Hunt syndrome (THS) is characterized by painful ophthalmoplegia secondary to idiopathic granulomatous inflammation of the cavernous sinus. The characteristic finding on MRI is an enhancing T1 isointense and T2 hypo- or hyperintense cavernous sinus mass lesion, which may result in focal narrowing of the ipsilateral internal carotid artery. Although the incidence is quite rare, it is a common diagnostic consideration in cases that present with multiple cranial neuropathies. However, the differential diagnosis for a unilateral cavernous sinus lesion in adults is broad and includes neoplastic, inflammatory (such as sarcoidosis and immunoglobulin G4-related disease [IgG4-RD]), infectious etiologies (such as syphilis and leprosy), as well as vascular lesions...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29684754/increases-in-helminth-induced-il-21-protein-levels-disappear-upon-sample-freezing
#19
Anupama Ariyaratne, Edina K Szabo, Joel Bowron, Constance A M Finney
IL-21 is a much studied cytokine that has been implicated in the regulation of TH1, TH2, TH17 and regulatory immune responses; its signalling is a promising therapeutic target for autoimmune, inflammatory and infectious diseases. Despite its biological importance, measuring IL-21 reliably has proved difficult. ELISAs are commonly used to measure cytokines in various biological samples. However, results obtained are only as good as the quality of the sample. Here, we show that when using fresh samples, a significant increase in IL-21 was measured in the intestinal homogenate of mice infected with the intestinal worm Heligmosomoides polygyrus...
April 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29684649/china-s-capacity-of-hospitals-to-deal-with-infectious-diseases-in-the-context-of-climate-change
#20
Michael Xiaoliang Tong, Alana Hansen, Scott Hanson-Easey, Jianjun Xiang, Scott Cameron, Qiyong Liu, Xiaobo Liu, Yehuan Sun, Philip Weinstein, Gil-Soo Han, Peng Bi
OBJECTIVES: Infectious diseases are a major cause of morbidity and mortality in China. The capacity of hospitals to deal with the challenge from emerging and re-emerging infectious diseases due to climate change is of great importance to population health. This study aimed to explore the capacity of hospitals in China to deal with such challenges. METHODS: A cross-sectional questionnaire survey was utilized to gauge information regarding capacity of hospitals to deal with infectious diseases in the context of climate change among 611 clinical professionals whose roles pertained to infectious disease diagnosis, treatment and management in Anhui Province of China...
April 16, 2018: Social Science & Medicine
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