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apoprotein B

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https://www.readbyqxmd.com/read/27887584/ratio-of-apob-ldl-a-potential-clinical-index-for-vascular-cognitive-impairment
#1
Cheng Qian, Fei Tan
BACKGROUND: Vascular cognitive impairment (VCI), compared to vascular dementia (VD), has a broader definition and highlights the effect of vascular disease in dementia, and stroke seems play an important role in the development of VCI. However, not all patients with brain infarcts suffer from VCI; unique risk factors appear to cause such progression. This study aimed to find potential risk factors of vascular cognitive impairment among patients with brain infarcts. METHODS: Thirty-seven dementia patients and 74 brain infarction patients were included; all had infarcts in both basilar ganglia...
November 25, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27824107/structural-changes-induced-by-acidic-ph-in-human-apolipoprotein-b-100
#2
José A Fernández-Higuero, Asier Benito-Vicente, Aitor Etxebarria, José Carlos G Milicua, Helena Ostolaza, José L R Arrondo, Cesar Martín
Acidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have expanded considerably, structural changes occurring in LDL particles have not been fully explored yet. The objectives of the present work were to study structural changes occurring in apoB100 by infrared spectroscopy (IR) and also LDL size and morphology by dynamic light scattering (DLS) and electron microscopy (EM) at both pH 7...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27630835/lipid-profile-in-cardiac-syndrome-x-association-with-helicobacter-pylori
#3
Yousef Rasmi, Javad Zeynalzadeh, Alireza Shirpoor, Mirhossein Seyedmohammadzad, Reza Hajhosseini
INTRODUCTION: Chronic inflammation caused by Helicobacter pylori (H.pylori) infection has a pathogenic role in Cardiac Syndrome X (CSX). In addition, it has shown that bacterial infection may affect blood lipids. AIM: To assess if H.pylori affects the level of lipid profile in CSX. MATERIALS AND METHODS: Eighty-eight CSX patients and 97 healthy controls were enrolled. The Total Cholesterol (TC), Triglyceride (TG), Lipoprotein A (LP{A}), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Apoprotein A1 (APOA1), and Apoprotein B (APOB) was estimated colorimetrically...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27586644/photochemical-activity-and-the-structure-of-chloroplasts-in-arabidopsis-thaliana-l-mutants-deficient-in-phytochrome-a-and-b
#4
Vladimir D Kreslavski, Anatoly A Kosobryukhov, Franz-Josef Schmitt, Galina A Semenova, Galina N Shirshikova, Aleksandra Yu Khudyakova, Suleyman I Allakhverdiev
The reduced content of photoreceptors, such as phytochromes, can decrease the efficiency of photosynthesis and activity of the photosystem II (PSII). For the confirmation of this hypothesis, the effect of deficiency in both phytochromes (Phy) A and B (double mutant, DM) in 7-27-day-old Arabidopsis thaliana plants on the photosynthetic activity was studied in absence and presence of UV-A radiation as a stress factor. The DM with reduced content of apoproteins of PhyA and PhyB and wild type (WT) plants with were grown in white and red light (WL and RL, respectively) of high (130 μmol quanta m(-2) s(-1)) and low (40 μmol quanta m(-2) s(-1)) intensity...
September 1, 2016: Protoplasma
https://www.readbyqxmd.com/read/27562917/autotaxin-lysophosphatidic-acid-axis-acts-downstream-of-apoprotein-b-lipoproteins-in-endothelial-cells
#5
Liron Gibbs-Bar, Hanoch Tempelhof, Rotem Ben-Hamo, Yona Ely, Alexander Brandis, Roy Hofi, Gabriella Almog, Tslil Braun, Ester Feldmesser, Sol Efroni, Karina Yaniv
OBJECTIVE: As they travel through the blood stream, plasma lipoproteins interact continuously with endothelial cells (ECs). Although the focus of research has mostly been guided by the importance of lipoproteins as risk factors for atherosclerosis, thrombosis, and other cardiovascular diseases, little is known about the mechanisms linking lipoproteins and angiogenesis under physiological conditions, and particularly, during embryonic development. In this work, we performed global mRNA expression profiling of endothelial cells from hypo-, and hyperlipidemic zebrafish embryos with the goal of uncovering novel mediators of lipoprotein signaling in the endothelium...
October 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27282536/berberine-as-a-photosensitizing-agent-for-antitumoral-photodynamic-therapy-insights-into-its-association-to-low-density-lipoproteins
#6
Nathalia Luiza Andreazza, Christine Vevert-Bizet, Geneviève Bourg-Heckly, Franck Sureau, Marcos José Salvador, Stephanie Bonneau
Recent years have seen a growing interest in Berberine, a phytochemical with multispectrum therapeutic activities, as anti-tumoral agent for photodynamic therapy (PDT). In this context, low density lipoproteins (LDL) play a key role in the delivery of the photosensitizer in tumor cells. We correlate the physicochemical parameters of the berberine association to LDL with the influence of LDL-delivery on its accumulation in a glioma cell line and on its photo-induced activity in view of antitumor PDT. Our results evidence an important binding of 400 berberine molecules per LDL...
August 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27267584/probing-the-pigment-binding-sites-in-lhcii-with-resonance-raman-spectroscopy-the-effect-of-mutations-at-s123
#7
Elizabeth Kish, Ke Wang, Manuel J Llansola-Portoles, Cristian Ilioaia, Andrew A Pascal, Bruno Robert, Chunhong Yang
Resonance Raman spectroscopy was used to evaluate the structure of light-harvesting chlorophyll (Chl) a/b complexes of photosystem II (LHCII), reconstituted from wild-type (WT) and mutant apoproteins over-expressed in Escherichia coli. The point mutations involved residue S123, exchanged for either P (S123P) or G (S123G). In all reconstituted proteins, lutein 2 displayed a distorted conformation, as it does in purified LHCII trimers. Reconstituted WT and S123G also exhibited a conformation of bound neoxanthin (Nx) molecules identical to the native protein, while the S123P mutation was found to induce a change in Nx conformation...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27165836/disorders-of-lipid-metabolism-in-nephrotic-syndrome-mechanisms-and-consequences
#8
REVIEW
Nosratola D Vaziri
Nephrotic syndrome results in hyperlipidemia and profound alterations in lipid and lipoprotein metabolism. Serum cholesterol, triglycerides, apolipoprotein B (apoB)-containing lipoproteins (very low-density lipoprotein [VLDL], immediate-density lipoprotein [IDL], and low-density lipoprotein [LDL]), lipoprotein(a) (Lp[a]), and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are increased in nephrotic syndrome. This is accompanied by significant changes in the composition of various lipoproteins including their cholesterol-to-triglyceride, free cholesterol-to-cholesterol ester, and phospholipid-to-protein ratios...
July 2016: Kidney International
https://www.readbyqxmd.com/read/27121620/pcsk9-association-with-lipoprotein-a
#9
Hagai Tavori, Devon Christian, Jessica Minnier, Deanna Plubell, Michael D Shapiro, Calvin Yeang, Ilaria Giunzioni, Mikael Croyal, P Barton Duell, Gilles Lambert, Sotirios Tsimikas, Sergio Fazio
RATIONALE: Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. Proprotein convertase subtilisin/kexin type 9 (PCSK9) selectively binds low-density lipoprotein; we hypothesized that it can also be associated with Lp(a) in plasma. OBJECTIVE: Characterize the association of PCSK9 and Lp(a) in 39 subjects with high Lp(a) levels (range 39-320 mg/dL) and in transgenic mice expressing either human apo(a) only or human Lp(a) (via coexpression of human apo(a) and human apolipoprotein B)...
June 24, 2016: Circulation Research
https://www.readbyqxmd.com/read/27063475/early-folding-events-during-light-harvesting-complex-ii-assembly-in-vitro-monitored-by-pulsed-electron-paramagnetic-resonance
#10
Niklas Fehr, Inés García-Rubio, Gunnar Jeschke, Harald Paulsen
Efficient energy transfer in the major light harvesting complex II (LHCII) of green plants is facilitated by the precise alignment of pigments due to the protein matrix they are bound to. Much is known about the import of the LHCII apoprotein into the chloroplast via the TOC/TIC system and its targeting to the thylakoid membrane but information is sparse about when and where the pigments are bound and how this is coordinated with protein folding. In vitro, the LHCII apoprotein spontaneously folds and binds its pigments if the detergent-solubilized protein is combined with a mixture of chlorophylls a and b and carotenoids...
June 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27004817/dietary-niacin-supplementation-suppressed-hepatic-lipid-accumulation-in-rabbits
#11
Lei Liu, Chunyan Li, Chunyan Fu, Fuchang Li
An experiment was conducted to investigate the effect of niacin supplementation on hepatic lipid metabolism in rabbits. Rex Rabbits (90 d, n = 32) were allocated to two equal treatment groups: Fed basal diet (control) or fed basal diet with additional 200 mg/kg niacin supplementation (niacin). The results show that niacin significantly increased the levels of plasma adiponectin, hepatic apoprotein B and hepatic leptin receptors mRNA (p<0.05), but significantly decreased the hepatic fatty acid synthase activity and adiponectin receptor 2, insulin receptor and acetyl-CoA carboxylase mRNA levels (p<0...
December 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26973181/-adipogenic-function-and-other-biologic-effects-of-insulin
#12
REVIEW
Y A Pankov
Studies on experimental animals with knockout of the insulin receptor gene Insr (in the whole body or in certain tissues) and/or related genes encoding proteins involved in realization of insulin signal transduction in target cells, have made an important contribution to the elucidation of insulin regulation of metabolism, particularly fat metabolism. Since the whole insulin secreted by b-cells, together with the products of gastrointestinal tract digestion of proteins, fats, and carbohydrates reach the liver, the latter is the first organ on which this hormone acts...
January 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/26912548/apoprotein-b-apoprotein-a-1-ratio-and-mortality-among-prevalent-dialysis-patients
#13
Yuji Sato, Shouichi Fujimoto, Tatsunori Toida, Hideto Nakagawa, Yasuhiro Yamashita, Takashi Iwakiri, Akihiro Fukuda, Shuji Iwatsubo
BACKGROUND AND OBJECTIVES: In dialysis patients, the associations between apoprotein profile and all-cause or cardiovascular disease (CVD)-related mortality are not well known. We, therefore, investigated whether apoprotein levels are associated with these events. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We undertook a prospective observational cohort study of prevalent hemodialysis patients aged ≥18 years (n=1081), who were followed for 4 years (2011-2014)...
May 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26894412/functioning-of-drug-metabolizing-microsomal-cytochrome-p450s-in-silico-probing-of-proteins-suggests-that-the-distal-heme-active-site-pocket-plays-a-relatively-passive-role-in-some-enzyme-substrate-interactions
#14
Avanthika Venkatachalam, Abhinav Parashar, Kelath Murali Manoj
PURPOSE: The currently held mechanistic understanding of microsomal cytochrome P450s (CYPs) seeks that diverse drug molecules bind within the deep-seated distal heme pocket and subsequently react at the heme centre. To explain a bevy of experimental observations and meta-analyses, we indulge a hypothesis that involves a "diffusible radical mediated" mechanism. This new hypothesis posits that many substrates could also bind at alternate loci on/within the enzyme and be reacted without the pertinent moiety accessing a bonding proximity to the purported catalytic Fe-O enzyme intermediate...
December 2016: In Silico Pharmacology
https://www.readbyqxmd.com/read/26830482/proteomic-profiling-in-the-spinal-cord-and-sciatic-nerve-in-a-global-cerebral-ischemia-induced-mechanical-allodynia-mouse-model
#15
Shinichi Harada, Wataru Matsuura, Masaoki Takano, Shogo Tokuyama
Central post-stroke pain (CPSP) is one of the complications of cerebral ischemia and neuropathic pain syndrome. At present, there are few studies of pain in regions such as the spinal cord or sciatic nerve in cerebral ischemic animal models. To identify proteomic changes in the spinal cord and sciatic nerve in global cerebral ischemic model mice, in the present study we performed an investigation using proteomic methods. In a comparison between the intensity of protein spots obtained from a sham and that from a bilateral carotid artery occulusion (BCAO) in spinal cord and sciatic nerve, the levels of 10 (spinal cord) and 7 (sciatic nerve) protein spots were altered...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26644350/structure-dynamic-basis-of-splicing-dependent-regulation-in-tissue-specific-variants-of-the-sodium-calcium-exchanger
#16
Su Youn Lee, Moshe Giladi, Hilla Bohbot, Reuben Hiller, Ka Young Chung, Daniel Khananshvili
Tissue-specific splice variants of Na(+)/Ca(2+) exchangers contain 2 Ca(2+)-binding regulatory domains (CBDs), CBD1 and CBD2. Ca(2+) interaction with CBD1 activates sodium-calcium exchangers (NCXs), and Ca(2+) binding to CBD2 alleviates Na(+)-dependent inactivation. A combination of mutually exclusive (A, B) and cassette (C-F) exons in CBD2 raises functionally diverse splice variants through unknown mechanisms. Here, the effect of exons on CBDs backbone dynamics were investigated in the 2-domain tandem (CBD12) of the brain, kidney, and cardiac splice variants by using hydrogen-deuterium exchange mass spectrometry and stopped-flow techniques...
March 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/26562806/excitation-energy-transfer-and-charge-separation-are-affected-in-arabidopsis-thaliana-mutants-lacking-light-harvesting-chlorophyll-a-b-binding-protein-lhcb3
#17
Małgorzata Adamiec, Krzysztof Gibasiewicz, Robert Luciński, Wojciech Giera, Przemysław Chełminiak, Sebastian Szewczyk, Weronika Sipińska, Rienk van Grondelle, Grzegorz Jackowski
The composition of LHCII trimers as well as excitation energy transfer and charge separation in grana cores of Arabidopsis thaliana mutant lacking chlorophyll a/b binding protein Lhcb3 have been investigated and compared to those in wild-type plants. In grana cores of lhcb3 plants we observed increased amounts of Lhcb1 and Lhcb2 apoproteins per PSII core. The additional copies of Lhcb1 and Lhcb2 are expected to substitute for Lhcb3 in LHCII trimers M as well as in the LHCII "extra" pool, which was found to be modestly enlarged as a result of the absence of Lhcb3...
December 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26545671/a-coconut-extra-virgin-oil-rich-diet-increases-hdl-cholesterol-and-decreases-waist-circumference-and-body-mass-in-coronary-artery-disease-patients
#18
Diuli A Cardoso, Annie S B Moreira, Glaucia M M de Oliveira, Ronir Raggio Luiz, Glorimar Rosa
INTRODUCTION: saturated fat restriction has been recommended for coronary arterial disease, but the role of coconut oil (Cocos nucifera L.) extra virgin, lauric acid source in the management of lipid profile remains unclear. OBJECTIVE: to evaluate the effect of nutritional treatment associated with the consumption of extra virgin coconut oil in anthropometric parameters and lipid profile. METHODS: we conducted a longitudinal study of 116 adults of both sexes presenting CAD...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26457520/crystallization-and-x-ray-analysis-of-the-transcription-activator-protein-c1-of-bacteriophage-p22-in-complex-with-the-pre-promoter-element
#19
Avisek Mondal, Rajagopal Chattopadhyaya, Ajit Bikram Datta, Pradeep Parrack
The transcription-activator protein C1 of the temperate phage P22 of Salmonella typhimurium plays a key role in the lytic versus lysogenic switch of the phage. A homotetramer of 92-residue polypeptides, C1 binds to an approximate direct repeat similar to the transcription activator CII of coliphage λ. Despite this and several other similarities, including 57% sequence identity to coliphage CII, many biochemical observations on P22 C1 cannot be explained based on the structure of CII. To understand the molecular basis of these differences, C1 was overexpressed and purified and subjected to crystallization trials...
October 2015: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/26393644/phytosterols-phytostanols-and-lipoprotein-metabolism
#20
REVIEW
Helena Gylling, Piia Simonen
The efficacy of phytosterols and phytostanols added to foods and food supplements to obtain significant non-pharmacologic serum and low density lipoprotein (LDL) cholesterol reduction is well documented. Irrespective of age, gender, ethnic background, body weight, background diet, or the cause of hypercholesterolemia and, even added to statin treatment, phytosterols and phytostanols at 2 g/day significantly lower LDL cholesterol concentration by 8%-10%. They do not affect the concentrations of high density lipoprotein cholesterol, lipoprotein (a) or serum proprotein convertase subtilisin/kexin type 9...
September 2015: Nutrients
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