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Influenza in pregnancy

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https://www.readbyqxmd.com/read/29661584/strategies-for-increasing-uptake-of-vaccination-in-pregnancy-in-high-income-countries-a-systematic-review
#1
REVIEW
Kate Alexandra Bisset, Pauline Paterson
INTRODUCTION: Vaccination in pregnancy is an effective method to protect against disease for the pregnant woman, foetus and new born infant. In England, it is recommended that pregnant women are vaccinated against pertussis and influenza. Improvement in the uptake of both pertussis and influenza vaccination among pregnant women is needed to prevent morbidity and mortality for both the pregnant women and unborn child. AIM: To identify effective strategies in increasing the uptake of vaccination in pregnancy in high-income countries and to make recommendations for England...
April 13, 2018: Vaccine
https://www.readbyqxmd.com/read/29630014/influenza-vaccination-pregnancy-safety-and-risk-of-early-pregnancy-loss
#2
Rhoda S Sperling, Laura E Riley
Since 2004, the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists have recommended routine influenza vaccination for all pregnant women in any trimester. Maternal influenza vaccination has been shown to decrease the risk of influenza and its complications among pregnant women and their infants in the first 6 months of life. In a recent article published in Vaccine, Donahue and colleagues reported a possible association between influenza vaccination when given very early in the first trimester and spontaneous abortion...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29627238/coverage-of-recommended-vaccines-during-pregnancy-in-flanders-belgium-fairly-good-but-can-we-do-better
#3
Kirsten Maertens, Tessa Braeckman, Stéphanie Blaizot, Heidi Theeten, Mathieu Roelants, Karel Hoppenbrouwers, Elke Leuridan, Pierre Van Damme, Corinne Vandermeulen
BACKGROUND: In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29625766/a-follow-up-comparative-safety-analysis-of-pandemic-h1n1-vaccination-during-pregnancy-and-risk-of-infant-birth-defects-among-u-s-military-mothers
#4
Ava Marie S Conlin, Anna T Bukowinski, Jordan A Levine, Zeina G Khodr, Navjot Kaur, Susan C Farrish, Carter J Sevick
OBJECTIVE: To update a previous assessment of birth defects among infants born to active duty U.S. military mothers who received the 2009-2010 pandemic H1N1 vaccine, in comparison to the 2008-2009 seasonal influenza vaccine, during pregnancy. Here, we updated the previous comparative analyses with a more refined definition for birth defects using an additional year of follow-up data from both inpatient and outpatient medical encounters. METHODS: The study population included 15,510 live born infants born to active duty mothers vaccinated during pregnancy with either the 2009-2010 pandemic H1N1 vaccine (n = 9033) or the 2008-2009 seasonal influenza vaccine (n = 6477)...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29578985/acog-committee-opinion-no-732-influenza-vaccination-during-pregnancy
#5
(no author information available yet)
Influenza vaccination is an essential element of prepregnancy, prenatal, and postpartum care because influenza can result in serious illness, including a higher chance of progressing to pneumonia, when it occurs during the antepartum or postpartum period. In addition to hospitalization, pregnant women with influenza are at increased risk of intensive care unit admission and adverse perinatal and neonatal outcomes. The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices and the American College of Obstetricians and Gynecologists recommend that all adults receive an annual influenza vaccine and that women who are or will be pregnant during influenza season receive an inactivated influenza vaccine as soon as it is available...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29578983/acog-committee-opinion-no-732-summary-influenza-vaccination-during-pregnancy
#6
(no author information available yet)
Influenza vaccination is an essential element of prepregnancy, prenatal, and postpartum care because influenza can result in serious illness, including a higher chance of progressing to pneumonia, when it occurs during the antepartum or postpartum period. In addition to hospitalization, pregnant women with influenza are at increased risk of intensive care unit admission and adverse perinatal and neonatal outcomes. The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices and the American College of Obstetricians and Gynecologists recommend that all adults receive an annual influenza vaccine and that women who are or will be pregnant during influenza season receive an inactivated influenza vaccine as soon as it is available...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29500057/nondiabetic-ketoacidosis-in-a-pregnant-woman-due-to-acute-starvation-with-concomitant-influenza-a-h1n1-and-respiratory-failure
#7
G Skalley, S Rodríguez-Villar
Threatening refractory metabolic acidosis due to short-term starvation nondiabetic ketoacidosis is rarely reported. Severe ketoacidosis due to starvation itself is a rare occurrence, and more so in pregnancy with a concomitant stressful clinical situation. This case report presents a nondiabetic woman admitted in intensive care for respiratory failure type 1 during the third trimester of pregnancy with a severe metabolic acidosis refractory to medical treatment. We diagnosed the patient with acute starvation ketoacidosis based on her history and the absence of other causes of high anion gap metabolic acidosis after doing a rigorous analysis of her acid-base disorder...
February 27, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29494274/understanding-the-barriers-to-uptake-of-antenatal-vaccination-by-women-from-culturally-and-linguistically-diverse-backgrounds-a-cross-sectional-study
#8
Sushena Krishnaswamy, Allen C Cheng, Euan M Wallace, Jim Buttery, Michelle Giles
The role of maternal vaccination in reducing neonatal morbidity and mortality is expanding but uptake remains suboptimal. While the barriers to uptake have been well described, women from minority groups have not been well represented in previous studies. In this study we examine the facilitators and barriers to uptake of antenatal vaccination by women from culturally and linguistically diverse backgrounds in Melbourne, Australia. 537 women attending antenatal care completed a survey; 69% were born overseas...
March 1, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29485347/meningococcal-vaccination-in-pregnancy
#9
Bahaa Abu Raya, Manish Sadarangani
Invasive meningococcal disease causes meningitis and septicemia worldwide with highest rates of disease occurring in children <2 years of age, and in particular young infants. Vaccination during pregnancy has been a successful strategy for prevention of other infections in young infants, most notably tetanus, pertussis and influenza. However, few studies of meningococcal vaccines in pregnancy have been undertaken, and none include the most commonly used current vaccines to prevent disease by capsular groups A, B, C, W and Y...
February 27, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29483030/acceptability-of-intranasal-live-attenuated-influenza-vaccine-influenza-knowledge-and-vaccine-intent-in-the-gambia
#10
Edwin P Armitage, Janko Camara, Sulayman Bah, Alice S Forster, Ed Clarke, Beate Kampmann, Thushan I de Silva
BACKGROUND: The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live attenuated influenza vaccines (LAIV) in young children provided an opportunity to study maternal attitudes towards LAIV for the first time in sub-Saharan Africa. We assess acceptability of LAIV, influenza knowledge and attitudes towards influenza vaccination in Gambian women...
February 23, 2018: Vaccine
https://www.readbyqxmd.com/read/29474132/who-s-the-target-mother-or-baby
#11
Alisa Kachikis, Linda O Eckert, Janet Englund
Maternal immunization for prevention of morbidity and mortality of pregnant women and their neonates due to infectious diseases is ongoing worldwide. The complexity of vaccine research and development in this population is challenging. Not only do vaccines for pregnant women require evidence of immunogenicity, potency, stability, and limited reactogenicity, they must also provide efficacy in decreasing morbidity for the pregnant woman, her fetus, and the neonate, demonstrate safety or lack of evidence of harm, and offer benefit or potential benefit of vaccination during pregnancy...
February 23, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29463582/infant-hospitalizations-and-mortality-after-maternal-vaccination
#12
Lakshmi Sukumaran, Natalie L McCarthy, Elyse O Kharbanda, Gabriela Vazquez-Benitez, Heather S Lipkind, Lisa Jackson, Nicola P Klein, Allison L Naleway, David L McClure, Rulin C Hechter, Alison T Kawai, Jason M Glanz, Eric S Weintraub
BACKGROUND: The Advisory Committee on Immunization Practices currently recommends pregnant women receive influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines. There are limited studies of the long-term safety in infants for vaccines administered during pregnancy. We evaluate whether maternal receipt of influenza and Tdap vaccines increases the risk of infant hospitalization or death in the first 6 months of life. METHODS: We included singleton, live birth pregnancies in the Vaccine Safety Datalink between 2004 and 2014...
February 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29452372/impact-of-timing-of-influenza-vaccination-in-pregnancy-on-transplacental-antibody-transfer-influenza-incidence-and-birth-outcomes-a-randomized-trial-in-rural-nepal
#13
Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, James M Tielsch
Background: Maternal influenza vaccination protects mothers and their infants in low resource settings but little is known about whether the protection varies by gestational age at vaccination. Methods: Women of childbearing age in rural southern Nepal were surveilled for pregnancy, consented and randomized to receive maternal influenza vaccination or placebo, with randomization stratified on gestational age (17-25 or 26-34 weeks). Enrollment occurred in two annual cohorts and vaccinations occurred from April 2011 through September 2013...
February 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29445450/prevention-of-influenza-related-illness-in-young-infants-by-maternal-vaccination-during-pregnancy
#14
REVIEW
Marta C Nunes, Shabir A Madhi
The influenza virus circulates yearly and causes global epidemics. Influenza infection affects all age groups and causes mild to severe illness, and young infants are at particular risk for serious disease. The most effective measure to prevent influenza disease is vaccination; however, no vaccine is licensed for use in infants younger than 6 months old. Thus, there is a crucial need for other preventive strategies in this high-risk age group. Influenza vaccination during pregnancy protects both the mothers and the young infants against influenza infection...
2018: F1000Research
https://www.readbyqxmd.com/read/29417364/maternal-care-providers-barriers-regarding-influenza-and-pertussis-vaccination-during-pregnancy-in-catalonia-spain
#15
Luz Maria Vilca, Cristina Martínez, Miriam Burballa, Magda Campins
Objective Maternal care providers (MCPs), obstetrician-gynaecologists and midwives are uniquely placed to increase maternal vaccination acceptance. We aimed to assess their knowledge, attitudes and practices regarding influenza and pertussis vaccination during pregnancy. Methods We conducted an online survey among MCPs working at "Attention to Sexual and Reproductive Health" (ASSIR) Units in Catalonia region. The survey included questions about current recommendations of influenza and pertussis immunization during pregnancy, reasons for not routinely recommending vaccination and several strategies to increase vaccination uptake...
February 7, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29400082/administration-rates-of-the-tdap-vaccine-in-obstetric-patients
#16
Jamie Koerner, Alicia B Forinash, Abigail M Yancey, Jessica Brinkmeyer, Spencer Dingman, Collin Miller, Judy Thompson, Laura Bergin, Julia D López, Amy Ravin
BACKGROUND: Infants younger than 6 months of age are at high risk for contracting pertussis because of not being fully vaccinated. The Advisory Committee on Immunization Practices (ACIP) recommends vaccinating all pregnant women with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) between 27 and 36 weeks to offer passive immunity to the infant to help protect them until they are able to receive the full pertussis series. OBJECTIVE: To assess and compare compliance with the 2013 ACIP recommendation of vaccinating pregnant women with Tdap at 27 to 36 weeks' gestation in 2 obstetric clinics...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29395531/strategies-to-implement-maternal-vaccination-a-comparison-between-standing-orders-for-midwife-delivery-a-hospital-based-maternal-immunisation-service-and-primary-care
#17
Sushena Krishnaswamy, Euan M Wallace, Jim Buttery, Michelle L Giles
Maternal vaccination is a safe and effective strategy to reduce maternal and neonatal morbidity and mortality from pertussis and influenza. However, despite recommendations for maternal vaccination since 2010, uptake remains suboptimal. Barriers to uptake have been studied widely and include lack of integration of vaccination into routine pregnancy care and access to vaccination services. Standing orders for administration of vaccines without the need for a physician review or prescription have been demonstrated to improve uptake as part of multi-model interventions to increase antenatal influenza and post-partum pertussis vaccination...
January 30, 2018: Vaccine
https://www.readbyqxmd.com/read/29390149/cord-blood-anti-parasite-il-10-as-risk-marker-for-compromised-vaccine-immunogenicity-in-early-childhood
#18
Indu Malhotra, A Desiree LaBeaud, Nathan Morris, Maxim McKibben, Peter Mungai, Eric Muchiri, Christopher L King, Charles H King
Background: Antenatal exposure to parasites can affect infants' subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns' anti-parasite cytokine profiles relate to IgG responses to standard vaccination during infancy. Methods: 450 Kenyan women were tested for parasitic infections during pregnancy. Their newborns' responses to malaria, schistosome, and filaria antigens were assessed in cord blood (CB) lymphocytes...
January 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29388196/vaccines-for-preventing-influenza-in-healthy-adults
#19
REVIEW
Vittorio Demicheli, Tom Jefferson, Eliana Ferroni, Alessandro Rivetti, Carlo Di Pietrantonj
BACKGROUND: The consequences of influenza in adults are mainly time off work. Vaccination of pregnant women is recommended internationally. This is an update of a review published in 2014. Future updates of this review will be made only when new trials or vaccines become available. Observational data included in previous versions of the review have been retained for historical reasons but have not been updated due to their lack of influence on the review conclusions. OBJECTIVES: To assess the effects (efficacy, effectiveness, and harm) of vaccines against influenza in healthy adults, including pregnant women...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29320882/the-impact-of-influenza-virus-infection-in-pregnancy
#20
Lucy K Somerville, Kerri Basile, Dominic E Dwyer, Jen Kok
Data from previous seasonal epidemics and pandemics have confirmed that pregnant women are at increased risk for severe influenza virus infection. Complications including fetal loss, higher rates of hospitalization and maternal death are most notable during the late gestational period. Antiviral therapy and influenza vaccination are recommended in pregnant women as both are effective and safe. This review discusses the epidemiology, pathophysiology, treatment and prevention of influenza virus infection in pregnancy, with a focus on recent developments...
February 2018: Future Microbiology
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