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https://www.readbyqxmd.com/read/28351063/from-communication-skills-to-skillful-communication-a-longitudinal-integrated-curriculum-for-critical-care-medicine-fellows
#1
Amanda L Roze des Ordons, Christopher J Doig, Philippe Couillard, Jason Lord
PROBLEM: Communication with patients and families in critical care medicine (CCM) can be complex and challenging. A longitudinal curricular model integrating multiple techniques within classroom and clinical milieus may facilitate skillful communication across diverse settings. APPROACH: In 2014-2015, the authors developed and implemented a curriculum for CCM fellows at the Cumming School of Medicine, University of Calgary, to promote the longitudinal development of skillful communication...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28350887/auditory-steady-state-responses-and-cochlear-implants-modeling-the-artifact-response-mixture-in-the-perspective-of-denoising
#2
Faten Mina, Virginie Attina, Yvan Duroc, Evelyne Veuillet, Eric Truy, Hung Thai-Van
Auditory steady state responses (ASSRs) in cochlear implant (CI) patients are contaminated by the spread of a continuous CI electrical stimulation artifact. The aim of this work was to model the electrophysiological mixture of the CI artifact and the corresponding evoked potentials on scalp electrodes in order to evaluate the performance of denoising algorithms in eliminating the CI artifact in a controlled environment. The basis of the proposed computational framework is a neural mass model representing the nodes of the auditory pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28350572/aripiprazole-lauroxil-pharmacokinetic-profile-of-this-long-acting-injectable-antipsychotic-in-persons-with-schizophrenia
#3
Marjie L Hard, Richard J Mills, Brian M Sadler, Ryan Z Turncliff, Leslie Citrome
BACKGROUND: Aripiprazole lauroxil is an extended-release prodrug of aripiprazole for intramuscular injection, approved for schizophrenia treatment. We developed a population pharmacokinetic (PopPK) model to characterize aripiprazole lauroxil PK and evaluate dosing scenarios likely to be encountered in clinical practice. METHODS: Data from 616 patients with schizophrenia, collected from 5 clinical studies, were used to construct the PopPK model. The model was subsequently used to evaluate various dose levels and frequency and the impact of dosing delay on aripiprazole concentrations...
March 27, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28346876/a-fluid-structure-interaction-model-of-the-internal-carotid-and-ophthalmic-arteries-for-the-noninvasive-intracranial-pressure-measurement-method
#4
Edgaras Misiulis, Algis Džiugys, Robertas Navakas, Nerijus Striūgas
Accurate and clinically safe measurements of intracranial pressure (ICP) are crucial for secondary brain damage prevention. There are two methods of ICP measurement: invasive and noninvasive. Invasive methods are clinically unsafe; therefore, safer noninvasive methods are being developed. One of the noninvasive ICP measurement methods implements the balance principle, which assumes that if the velocity of blood flow in both ophthalmic artery segments - the intracranial (IOA) and extracranial (EOA) - is equal, then the acting ICP on the IOA and the external pressure (Pe) on the EOA are also equal...
March 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28346796/harnessing-external-cues-development-and-evaluation-of-an-in-vitro-culture-system-for-osteochondral-tissue-engineering
#5
Deborah L Dorcemus, Eve O George, Caroline N Dealy, Syam P Nukavarapu
Over the last decade, engineered structures have been developed for osteochondral (OC) tissue regeneration. While the optimal structure design is yet to be determined, these scaffolds require in vitro evaluation before clinical use. However, the means by which complex scaffolds, such as OC scaffolds, can be tested are limited. Taking advantage of a mesenchymal stem cell's (MSC's) ability to respond to its surrounding we harness external cues, such as the cell's mechanical environment and delivered factors, to create an in vitro culture system for OC tissue engineering with a single cell source on a gradient yet integrated scaffold system...
March 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28346222/sign-determination-methods-for-the-respiratory-signal-in-data-driven-pet-gating
#6
Ottavia Bertolli, Simon Arridge, Scott D Wollenweber, Charles W Stearns, Brian F Hutton, Kris Thielemans
Patient respiratory motion during PET image acquisition leads to blurring in the reconstructed images and may cause significant artifacts, resulting in decreased lesion detectability, inaccurate standard uptake value calculation and incorrect treatment planning in radiation therapy. To reduce these effects data can be regrouped into (nearly) 'motion-free' gates prior to reconstruction by selecting the events with respect to the breathing phase. This gating procedure therefore needs a respiratory signal: on current scanners it is obtained from an external device, whereas with data driven (DD) methods it can be directly obtained from the raw PET data...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28346016/dsl-prescriptive-targets-for-bone-conduction-devices-adaptation-and-comparison-to-clinical-fittings
#7
William E Hodgetts, Susan D Scollie
OBJECTIVE: To develop an algorithm that prescribes targets for bone conduction frequency response shape, compression, and output limiting, along with a clinical method that ensures accurate transforms between assessment and verification stages of the clinical workflow. DESIGN: Technical report of target generation and validation. STUDY SAMPLE: We recruited 39 adult users of unilateral percutaneous bone conduction hearing aids with a range of unilateral, bilateral, mixed and conductive hearing losses across the sample...
March 27, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#8
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28345852/layer-number-dependent-antibacterial-and-osteogenic-behaviors-of-graphene-oxide-electrophoretic-deposited-on-titanium
#9
Jiajun Qiu, Hao Geng, Donghui Wang, Shi Qian, Hongqin Zhu, Yuqin Qiao, Wenhao Qian, Xuanyong Liu
Graphene oxide has attracted widespread attentions in the biomedical fields due to its excellent biocompatibility. Herein we investigated the layer-number dependent antibacterial and osteogenic behaviors of graphene oxide in biointerfaces. Graphene oxide with different layer numbers was deposited on the titanium surfaces by cathodal electrophoretic deposition with varied deposition voltages. The initial cell adhesion and spreading, cell proliferation and osteogenic differentiation were observed from all the samples using rat bone mesenchymal stem cells...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28345508/use-of-a-novel-portable-led-based-capillary-refill-time-simulator-within-a-disaster-triage-context
#10
Todd P Chang, Genevieve Santillanes, Ilene Claudius, Phung K Pham, James Koved, John Cheyne, Marianne Gausche-Hill, Amy H Kaji, Saranya Srinivasan, J Joelle Donofrio, Cynthia Bir
Introduction A simple, portable capillary refill time (CRT) simulator is not commercially available. This device would be useful in mass-casualty simulations with multiple volunteers or mannequins depicting a variety of clinical findings and CRTs. The objective of this study was to develop and evaluate a prototype CRT simulator in a disaster simulation context. METHODS: A CRT prototype simulator was developed by embedding a pressure-sensitive piezo crystal, and a single red light-emitting diode (LED) light was embedded, within a flesh-toned resin...
March 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28344719/residents-perceptions-of-simulation-as-a-clinical-learning-approach
#11
Catharine M Walsh, Ankit Garg, Stella L Ng, Fenny Goyal, Samir C Grover
BACKGROUND: Simulation is increasingly being integrated into medical education; however, there is little research into trainees' perceptions of this learning modality. We elicited trainees' perceptions of simulation-based learning, to inform how simulation is developed and applied to support training. METHODS: We conducted an instrumental qualitative case study entailing 36 semi-structured one-hour interviews with 12 residents enrolled in an introductory simulation-based course...
February 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344608/a-brief-look-at-model-based-dose-calculation-principles-practicalities-and-promise
#12
REVIEW
Ron S Sloboda, Hali Morrison, Brie Cawston-Grant, Geetha V Menon
Model-based dose calculation algorithms (MBDCAs) have recently emerged as potential successors to the highly practical, but sometimes inaccurate TG-43 formalism for brachytherapy treatment planning. So named for their capacity to more accurately calculate dose deposition in a patient using information from medical images, these approaches to solve the linear Boltzmann radiation transport equation include point kernel superposition, the discrete ordinates method, and Monte Carlo simulation. In this overview, we describe three MBDCAs that are commercially available at the present time, and identify guidance from professional societies and the broader peer-reviewed literature intended to facilitate their safe and appropriate use...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28344604/3d-image-based-adapted-high-dose-rate-brachytherapy-in-cervical-cancer-with-and-without-interstitial-needles-measurement-of-applicator-shift-between-imaging-and-dose-delivery
#13
Leif Karlsson, Per Thunberg, Anders With, Louise Bohr Mordhorst, Jan Persliden
PURPOSE: Using 3D image-guided adaptive brachytherapy for cervical cancer treatment, it often means that patients are transported and moved during the treatment procedure. The purpose of this study was to determine the intra-fractional longitudinal applicator shift in relation to the high risk clinical target volume (HR-CTV) by comparing geometries at imaging and dose delivery for patients with and without needles. MATERIAL AND METHODS: Measurements were performed in 33 patients (71 fractions), where 25 fractions were without and 46 were with interstitial needles...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28344159/significance-of-preoperative-planning-software-for-puncture-and-channel-establishment-in-percutaneous-endoscopic-lumbar-discectomy-a-study-of-40-cases
#14
Zhouyang Hu, Xinhua Li, Jian Cui, Xiaobo He, Cong Li, Yingchao Han, Jie Pan, Mingjie Yang, Jun Tan, Lijun Li
BACKGROUND: Preoperative planning software has been widely used in many other minimally invasive surgeries, but there is a lack of information describing the clinical benefits of existing software applied in percutaneous endoscopic lumbar discectomy(PELD). This study aimed to compare the clinical efficacy of preoperative planning software in puncture and channel establishment of PELD with routine methods in treating lumbar disc herniation (LDH). MATERIAL AND METHODS: From June 2016 to October 2016, 40 patients who had single L4/5 or L5/S1 disc herniation were divided into two groups...
March 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28343953/development-and-validation-of-a-novel-and-cost-effective-animal-tissue-model-for-training-transurethral-resection-of-the-prostate
#15
Sichuan Hou, Gillian Ross, Iain Tait, Paul Halliday, Benjie Tang
OBJECTIVES: To develop and validate a new and cost-effective animal tissue training model for practicing resection skills of transurethral resection of the prostate (TURP). METHODS AND MATERIALS: A porcine kidney was prepared and restructured to simulate the relevant anatomy of the human prostate. The restructured prostate was connected to an artificial urethra and bladder. Face, content, and construct validity of the model was carried out using a 5-point Likert scale questionnaire, and comparison in task performance between participants and experts was made using observational clinical human reliability analysis...
March 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28343752/efficacy-of-tedizolid-against-methicillin-resistant-staphylococcus-aureus-and-peptostreptococcus-anaerobius-in-thigh-mixed-infection-mouse-model
#16
Yuka Yamagishi, Hiroshige Mikamo, Hideo Kato, Naoya Nishiyama, Nobuhiro Asai, Yusuke Koizumi, Daisuke Sakanashi, Hiroyuki Suematsu, Katsuhiko Matsuura, Mao Hagihara
OBJECTIVE: The purpose of this study is to compare the antimicrobial activity of human simulated exposures of tedizolid 200 mg daily, and linezolid 600 mg every 12 h for the treatment of complicated skin and skin structure infection (cSSSI) caused by MRSA and Peptostreptococcus anaerobius in both the neutropenic mice thigh mixed-infection models. MATERIAL AND METHOD: Tedizolid phosphate and linezolid were used for all in vivo testing. A total of one MRSA and two P...
March 23, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28343558/simulator-based-obstetric-ultrasound-training-a-prospective-randomized-single-blinded-study
#17
Hadar Rosen, Rory Windrim, Yee Man Lee, Lara Gotha, Vsevolod Perelman, Stefania Ronzoni
OBJECTIVE: To compare the use of simulator-based and patient-based obstetric ultrasound training. METHODS: This was a prospective, randomized, single-blinded trial. Eighteen consenting obstetric trainees with minimal previous ultrasound exposure were recruited. Enrolled patients were also fully consenting. Mid-trimester fetal brain anatomy in the standard planes (i.e., biparietal diameter and head circumference, cavum septum pellucidum, posterior fossa, and lateral ventricle) was chosen as a surrogate for all fetal anatomy ultrasound training...
March 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28343349/modernizing-quality-of-life-assessment-development-of-a-multidimensional-computerized-adaptive-questionnaire-for-patients-with-schizophrenia
#18
Pierre Michel, Karine Baumstarck, Christophe Lancon, Badih Ghattas, Anderson Loundou, Pascal Auquier, Laurent Boyer
OBJECTIVE: Quality of life (QoL) is still assessed using paper-based and fixed-length questionnaires, which is one reason why QoL measurements have not been routinely implemented in clinical practice. Providing new QoL measures that combine computer technology with modern measurement theory may enhance their clinical use. The aim of this study was to develop a QoL multidimensional computerized adaptive test (MCAT), the SQoL-MCAT, from the fixed-length SQoL questionnaire for patients with schizophrenia...
March 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28343335/a-new-infant-hybrid-respiratory-simulator-preliminary-evaluation-based-on-clinical-data
#19
Barbara Stankiewicz, Krzysztof J Pałko, Marek Darowski, Krzysztof Zieliński, Maciej Kozarski
A new hybrid (numerical-physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A numerical, seven-compartmental model of the respiratory system mechanics allows the operator to simulate global and peripheral obstruction and restriction of the lungs. The physical part of the simulator is a piston-based construction of impedance transformer. LabVIEW real-time software coordinates the work of both parts of the simulator and its interaction with a ventilator...
March 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28343228/focal-brain-injury-associated-with-a-model-of-severe-hypoxic-ischemic-encephalopathy-in-nonhuman-primates
#20
Ryan M McAdams, Ronald J McPherson, Raj P Kapur, Sandra E Juul
Worldwide, hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. To better understand the mechanisms contributing to brain injury and improve outcomes in neonates with HIE, better preclinical animal models that mimic the clinical situation following birth asphyxia in term newborns are needed. In an effort to achieve this goal, we modified our nonhuman primate model of HIE induced by in utero umbilical cord occlusion (UCO) to include postnatal hypoxic episodes, in order to simulate apneic events in human neonates with HIE...
March 25, 2017: Developmental Neuroscience
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