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https://www.readbyqxmd.com/read/29328028/-skin-pathology-in-diabetes-mellitus-clinical-and-pathophysiological-correlations-review
#1
K Kochet, I Lytus, I Svistunov, O Sulaieva
Skin pathology is registered in vast majority of patients with diabetes mellitus (DM). Despite the abundance of publications on dermatological problems in DM, there is still a number of gaps to be discussed in terms of pathophysiological mechanisms. The goal of this review was to assess the mechanisms of development of different skin pathologies under DM. One of the key pathogenic mechanisms of skin lesions in diabetes is hyperglycemia and the effects of the advanced glycation end products, inducing oxidative stress, endothelial dysfunction and inflammation; that in its turn can accelerate the mechanisms of skin aging, the development of diabetic dermopathy and scleredema diabeticorum...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29283443/letter-on-european-dermatology-forum-s1-guideline-on-the-diagnosis-and-treatment-of-sclerosing-diseases-of-the-skin-part-2-scleromyxedema-scleredema-and-nephrogenic-systemic-fibrosis
#2
Patrick Mark, Ilona Dekkers, Peter Blankestijn, Tim Leiner, Giles Roditi
We read with interest the guidelines recently published on sclerosing diseases of the skin (Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis)[1, 2]. However, we are concerned that the guideline recommendations proposed for prevention of nephrogenic systemic fibrosis (NSF) are potentially dangerous. Although we recognise the challenges in constructing comprehensive guidelines, we are concerned that this may be because the guidelines have not involved a multidisciplinary team. This article is protected by copyright...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29280826/an-unusual-cause-of-dysphagia
#3
Soumya Chatterjee, Brian J Hedman, Donald F Kirby
Scleredema adultorum of Buschke is a rare scleroderma mimic characterized by woody induration of the skin involving the back of the neck, interscapular region, upper and mid back, and sometimes the face, upper chest, and upper arms. Dysphagia is rare and not well characterized. We describe a case of scleredema that developed significant dysphagia affecting both the oropharyngeal phase and the esophageal phase of deglutition. Diagnostic evaluation revealed mild-moderate oropharyngeal and severe esophageal dysmotility...
December 27, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29241760/miscellaneous-skin-disease-and-the-metabolic-syndrome
#4
Sila Seremet, Mehmet Salih Gurel
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/28944958/paclitaxel-related-scleredema-like-skin-changes-in-a-patient-with-breast-cancer
#5
Naomi Tani, Kazunari Sugita, Osamu Yamamoto
No abstract text is available yet for this article.
September 25, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28895446/serositis-in-a-child-with-scleredema-of-buschke-an-unusual-association-and-improvement-following-glucocorticoids
#6
D Sharma, A Somasekhara-Aradhya, P Vignesh, U-N Saikia, S Singh
No abstract text is available yet for this article.
September 12, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28868289/pathophysiological-mechanisms-in-sclerosing-skin-diseases
#7
REVIEW
Beate Eckes, Fang Wang, Pia Moinzadeh, Nicolas Hunzelmann, Thomas Krieg
Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28738698/implementation-and-evaluation-of-a-rehabilitation-concept-in-a-patient-suffering-from-scleredema-adultorum-buschke-a-case-report
#8
Michael Mickel, Ahmad Jalili, Christina Gesslbauer, Richard Crevenna
PURPOSE: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. METHODS: A treatment plan was developed containing therapeutic ultrasound, manual lymphatic drainage, and physiotherapy...
July 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28712039/cutaneous-manifestations-of-scleroderma-and-scleroderma-like-disorders-a-comprehensive-review
#9
REVIEW
Caterina Ferreli, Giulia Gasparini, Aurora Parodi, Emanuele Cozzani, Franco Rongioletti, Laura Atzori
Scleroderma refers to an autoimmune connective tissue fibrosing disease, including three different subsets: localized scleroderma, limited cutaneous systemic sclerosis, and diffuse cutaneous systemic sclerosis with divergent patterns of organ involvement, autoantibody profiles, management, and prognostic implications. Although systemic sclerosis is considered the disease prototype that causes cutaneous sclerosis, there are many other conditions that can mimic and be confused with SSc. They can be classified into immune-mediated/inflammatory, immune-mediated/inflammatory with abnormal deposit (mucinoses), genetic, drug-induced and toxic, metabolic, panniculitis/vascular, and (para)neoplastic disorders according to clinico-pathological and pathogenetic correlations...
December 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28606036/scleroderma-like-disorders
#10
Amit Sharma
Scleroderma is a term used to describe diseases that involve hardening and tightening of the skin and the underlying subcutaneous connective tissue. It could be localized to skin and subcutaneous tissue, or may involve the internal organs too in systemic sclerosis. There are disorders that can cause hardening and tightening of skin and mimic scleroderma but are rarely associated with Raynaud phenomenon, sclerodactyly, and autoantibodies in the serum, features specific to scleroderma/systemic sclerosis. These are termed as "scleroderma variants" or "scleroderma like disorders"...
June 11, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28573670/successful-treatment-with-ivig-therapy-of-diabetes-associated-scleredema-severe-progressive-case-and-review-of-the-literature
#11
Caroline Kennemer, Peter Pavlidakey, Naveed Sami
Scleredema is a deposition disorder which presents as diffuse, symmetric, non-pitting skin induration from dermal deposits of glycosaminoglycans ("mucins"). It classically affects the upper back and posterior neck, often causing skin tightness and decreased range of motion. In most patients the clinical course is chronic and treatment options are limited. We report a case of a patient diagnosed with scleredema associated with longstanding insulin dependent diabetes who was treated successfully with IVIg. Additionally, we have reviewed the literature reporting other patients with scleredema treated with IVIg...
June 2, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28374407/cutaneous-manifestations-of-diabetes-mellitus-a-review
#12
REVIEW
Ana Luiza Lima, Tanja Illing, Sibylle Schliemann, Peter Elsner
Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Noninfectious as well as infectious diseases have been described as dermatologic manifestations of diabetes mellitus...
August 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28329532/idiopathic-scleredema
#13
Elise Ng, Rachel Rosenstein, Vitaly Terushkin, Shane Meehan, Miriam Keltz Pomeranz
Scleredema, which also is known as scleredemaadultorum of Buschke, is an uncommonsclerodermiform condition that is characterizedby progressive thickening and hardening of theskin due to excessive dermal mucin and collagendeposition. The clinical course is variable, andprogression of disease may lead to functionalimpairment with limitations in mobility. The etiologyand pathogenesis are unknown although severalwell-known associations include streptococcalinfection; diabetes mellitus, particularly withmetabolic syndrome; and monoclonal gammopathy...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28149667/scleredema-of-buschke
#14
Rajaie Namas, Ambreen Ashraf
No abstract text is available yet for this article.
December 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27708956/therapy-resistant-idiopathic-scleredema-an-underlying-pathology-not-always-present
#15
Melike Kalfa, Hayriye Koçanaoğulları, Figen Yargucu Zihni, Gonca Karabulut, Hakan Emmungil, Vedat İnal
Scleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. The patient was followed regularly for 13 years and did not respond to various combinations of immunosuppressants and psoralen plus ultraviolet A therapy. Treatment of scleredema is quite difficult and of limited success. At present, there is no proved treatment for this disease...
December 2015: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27573162/atypical-scleredema-involving-the-hands-in-an-adolescent
#16
Caroline M Lewis, April T Sanchez, Loretta S Davis
Scleredema is a rare and incompletely understood disorder characterized by progressive skin thickening and induration typically affecting the trunk, neck, and proximal upper extremities. Hand and finger involvement is exceptionally rare, having been reported in only two infection-related cases. We present an atypical case of postinfectious scleredema involving the hands and discuss scleredema as an important potential cause of hand tightness and induration in adolescents.
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27530780/-risk-factors-for-concurrent-sepsis-in-neonates-with-necrotizing-enterocolitis
#17
Yao An, Li Liu, Qiu-Yu Li, Ya-Lin Ran, Lu-Quan Li
OBJECTIVE: To investigate the risk factors for concurrent sepsis in neonates with necrotizing enterocolitis (NEC). METHODS: A retrospective analysis was performed for the clinical data of 273 neonates with NEC. The risk factors for concurrent sepsis were analyzed from the aspects of perinatal factors and treatment regimen before the diagnosis of NEC. RESULTS: The incidence rate of concurrent sepsis in NEC was 32.2% (88/273). The neonates with stage III NEC had a significantly higher incidence rate of concurrent sepsis than those with stage II NEC (69...
August 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27310540/scleredema-of-buschke-associated-with-difficult-to-control-type-2-diabetes-mellitus
#18
Luciana Rodino Lemes, Gabriele Medina Vilela, Sandra Maria Barbosa Durães, Enoi Aparecida Guedes Vilar
Scleredema of Buschke (SB) is a rare disorder of connective tissue characterized by diffuse non-pitting induration of the skin, mainly on the cervical, deltoid and dorsal regions. It is a cutaneous mucinosis of unknown etiology and is associated with bacterial or viral infections, hematological disorders and diabetes mellitus. Histopathological examination shows thickened dermis with wide collagen bundles separated by gaps that correspond to mucopolysaccharide deposits, visualized using special staining. Several treatments are reported in the literature without well-established results...
May 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/26806503/-monoclonal-immunoglobulin-m-ig-and-skin-diseases-from-the-group-of-mucinoses-scleredema-adultorum-buschke-and-scleromyxedema-description-of-four-cases-and-an-overview-of-therapies
#19
Zdeněk Adam, Petr Szturz, Marta Krejčí, Vladimír Vašků, Luděk Pour, Eva Michalková, Sabina Ševčíková, Zdeňka Čermáková, Karel Veselý, Jíří Vaníček, Eva Pourová, Zdeněk Král, Jiří Mayer
INTRODUCTION: The mucinoses of the type of scleredema and scleromyxedema are diseases marked by excessive production of mucin deposits in the skin and subcutaneous tissue, which causes skin hardening. The skin and subcutaneous deposits hamper the movement of limbs, the thorax as well as mouth. The same mechanism also damages other organs (the heart, lungs, oesophagus). It is probably caused by the stimulation of mucin production in fibroblasts by immunoglobulins, frequently monoclonal immunoglobulin...
December 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26538693/prevalence-of-skin-changes-in-diabetes-mellitus-and-its-correlation-with-internal-diseases-a-single-center-observational-study
#20
Kaushik Ghosh, KapilDev Das, Susmita Ghosh, Sisir Chakraborty, Sanat Kumar Jatua, Ambarish Bhattacharya, Manas Ghosh
BACKGROUND AND AIM: This single-center observational cross-sectional study has been done in an attempt to find out the prevalence of various skin manifestations in diabetes patients (DM) and their correlation with diabetes control and complications. MATERIALS AND METHODS: Skin manifestations present over 12 months among those attend diabetes clinic were included in the study. Apart from demographic data and type, patients were also screened for micro vascular complications and control of diabetes over last 3 months...
September 2015: Indian Journal of Dermatology
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