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https://www.readbyqxmd.com/read/29791908/a-de-novo-kcna1-mutation-in-a-patient-with-tetany-and-hypomagnesemia
#1
Jenny van der Wijst, Martin Konrad, Sjoerd A J Verkaart, Marcin Tkaczyk, Femke Latta, Janine Altmüller, Holger Thiele, Bodo Beck, Karl Peter Schlingmann, Jeroen H F de Baaij
Mutations in the KCNA1 gene encoding the voltage-gated potassium (K+) channel Kv1.1 have been linked to rare neurological syndromes, episodic ataxia type 1 (EA1) and myokymia. In 2009, a KCNA1 mutation was identified in a large family with autosomal dominant hypomagnesemia. Despite efforts in establishing a genotype-phenotype correlation for the wide variety of symptoms in EA1, little is known on the serum magnesium (Mg2+) levels in these patients. In the present study, we describe a new de novo KCNA1 mutation in a Polish patient with tetany and hypomagnesemia...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29783630/does-molimina-indicate-ovulation-prospective-data-in-a-hormonally-documented-single-cycle-in-spontaneously-menstruating-women
#2
Jerilynn C Prior, Chiaki Konishi, Christine L Hitchcock, Elaine Kingwell, Patti Janssen, Anthony P Cheung, Nichole Fairbrother, Azita Goshtasebi
Approximately 33% of normal-length (21⁻35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (-0.86%/year). Molimina, non-distressing premenstrual experiences, may detect ovulation within normal-length cycles. This prospective study assessed the relationship between molimina and ovulation. After 1-cycle of daily diary and first morning urine collections, women answered the Molimina Question (MQ): " Can you tell by the way you feel that your period is coming? " and were invited to share (a) predictive premenstrual experience(s)...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#3
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29777629/mechanisms-of-metformin-action-in-and-out-of-the-gut
#4
EDITORIAL
Takahiro Minamii, Munenobu Nogami, Wataru Ogawa
One hundred years have passed since guanidine, a precursor compound of biguanides and thus of metformin, was found to have a glucose-lowering effect in live animals1 . In this historical study, C. K. Watanabe1 did not set out to identify glucose-lowering agents but rather to understand the mechanism underlying the development of tetany in animals that have undergone parathyroidectomy. Watanabe 1 concluded that guanidine is a pathogenic factor responsible for tetany because its administration in rabbits resulted in "tetany-like" muscle cramps associated with low blood glucose levels...
May 19, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29775929/negative-impacts-of-elevated-nitrate-on-physiological-performance-are-not-exacerbated-by-low-ph
#5
Daniel F Gomez Isaza, Rebecca L Cramp, Craig E Franklin
Multiple environmental stressors, including nutrient effluents (i.e. nitrates [NO3 - ]) and altered pH regimes, influence the persistence of freshwater species in anthropogenically disturbed habitats. Independently, nitrate and low pH affect energy allocation by increasing maintenance costs and disrupting oxygen uptake, which ultimately results in impacts upon whole animal performance. However, the interaction between these two stressors has not been characterised. To address this, the effects of nitrate and pH and their interaction on aerobic scope and physiological performance were investigated in the blueclaw crayfish, Cherax destructor...
May 15, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775120/successful-improvement-of-pain-symptomatology-in-a-suspected-case-of-cramp-fasciculation-syndrome-via-interventional-pain-treatment
#6
Anita Gupta, Lucas First, Celeste A Swain
Peripheral nerve hyperexcitability (PNH) syndromes are a rare set of neuromuscular disorders that include cramp-fasciculation syndrome (CFS) and Isaacs syndrome (IS). Successful treatment of these diseases has been achieved with antiepileptic medications; however, chronic pain symptoms can persist. We provide a case report of a 25-year-old female who has suffered from painful severe muscle spasms and fasciculations since childhood. With CFS as our working diagnosis, a treatment regimen using interventional pain techniques, including sympathetic chain blocks, ketamine infusions, and trigger point injections, resulted in a significant decrease in the patient's chronic pain symptoms...
May 18, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29774156/pilot-study-of-orphenadrine-as-a-novel-treatment-for-muscle-cramps-in-patients-with-liver-cirrhosis
#7
Sherief Abd-Elsalam, Ferial El-Kalla, Lobna A Ali, Samah Mosaad, Walaa Alkhalawany, Berihan Elemary, Rehab Badawi, Asmaa Elzeftawy, Amr Hanafy, Asem Elfert
Background and aims: Muscle cramps markedly affect the quality of life in cirrhotic patients with no available highly effective treatment. The aim of this study was to assess the safety and efficacy of orphenadrine in the treatment of muscle cramps in cirrhotic patients. Methods: The study enrolled 30 liver cirrhosis patients complaining of frequent muscle cramps (≥3 per week), who were randomized to receive either orphenadrine 100 mg or calcium carbonate 500 mg twice daily as a control for one month...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29770717/treatment-patterns-and-health-care-resource-utilization-and-costs-in-heavy-menstrual-bleeding-a-japanese-claims-database-analysis
#8
Sayako Akiyama, Erika Tanaka, Olivier Cristeau, Yoshie Onishi, Yutaka Osuga
AIMS: Heavy menstrual bleeding (HMB) is a highly prevalent condition characterized by excessive menstrual blood loss and cramping that interferes with activities of daily life. The aim of our study was to investigate treatment patterns in HMB in Japan, and to assess healthcare resource utilization and costs among women newly diagnosed with the condition. MATERIALS AND METHODS: We retrospectively analysed health insurance data available in the Japan Medical Data Center (JMDC) database on women aged 18-49 years who were newly diagnosed with primary or secondary HMB...
May 17, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29765883/the-validity-of-two-neuromotor-assessments-for-predicting-motor-performance-at-12-months-in-preterm-infants
#9
You Hong Song, Hyun Jung Chang, Yong Beom Shin, Young Sook Park, Yun Hee Park, Eun Sol Cho
Objective: To evaluate the validity of the Test of Infant Motor Performance (TIMP) and general movements (GMs) assessment for predicting Alberta Infant Motor Scale (AIMS) score at 12 months in preterm infants. Methods: A total of 44 preterm infants who underwent the GMs and TIMP at 1 month and 3 months of corrected age (CA) and whose motor performance was evaluated using AIMS at 12 months CA were included. GMs were judged as abnormal on basis of poor repertoire or cramped-synchronized movements at 1 month CA and abnormal or absent fidgety movement at 3 months CA...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29761101/fibromyalgia-syndrome-a-case-report-on-controlled-remission-of-symptoms-by-a-dietary-strategy
#10
Silvia Maria Lattanzio, Francesca Imbesi
A 34-year-old woman suffered from significant chronic pain, depression, non-restorative sleep, chronic fatigue, severe morning stiffness, leg cramps, irritable bowel syndrome, hypersensitivity to cold, concentration difficulties, and forgetfulness. Blood tests were negative for rheumatic disorders. The patient was diagnosed with Fibromyalgia syndrome (FMS). Due to the lack of effectiveness of pharmacological therapies in FMS, she approached a novel metabolic proposal for the symptomatic remission. Its core idea is supporting serotonin synthesis by allowing a proper absorption of tryptophan assumed with food, while avoiding, or at least minimizing the presence of interfering non-absorbed molecules, such as fructose and sorbitol...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29752415/a-pathogenic-skin-fungus-and-sloughing-exacerbate-cutaneous-water-loss-in-amphibians
#11
Catherine J M Russo, Michel E B Ohmer, Rebecca L Cramp, Craig E Franklin
Batrachochytrium dendrobatidis ( Bd ) is a pathogenic fungus that causes the cutaneous, infectious disease chytridiomycosis and has been implicated in population declines of numerous anuran species worldwide. Proximate cause of death by chytridiomycosis is asystolic cardiac arrest as a consequence of severe disruption to electrolyte balance. Animals heavily infected with Bd also experience a disruption to their skin sloughing regime, indicating that core functions of the skin, such as water retention, may be severely impacted...
May 11, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29747750/crocus-sativus-a-natural-food-coloring-and-flavoring-has-potent-anti-tumor-properties
#12
REVIEW
Zahra Khorasanchi, Mojtaba Shafiee, Farnoush Kermanshahi, Majid Khazaei, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Behnoush Kermanshahi, Gordon A Ferns, Amir Avan, Seyed Mahdi Hassanian
BACKGROUND: Saffron, the dried stigmas of Crocus sativus L., is a highly valued agricultural product that is used mainly as a food coloring and flavoring agent. Three main secondary metabolites of Crocus sativus including crocin, picrocrocin, and safranal are responsible for the color, the bitter taste and for the odor and aroma, respectively. As a component of traditional medicine, saffron has been utilized as a medicinal herb for treating various ailments including cramps, asthma, liver disease, menstruation disorders, pain, and in the pathogenesis of cancer...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29740522/a-case-report-of-nephrotic-syndrome-while-undergoing-quinine-therapy
#13
Brittany Albrecht, Shelley Giebel, Michelle McCarron, Bhanu Prasad
We summarize the case of an 81-year-old Caucasian female who presented to her family physician with signs and symptoms of nephrotic syndrome following a brief exposure to quinine. Prior to that visit, she was clinically well with no chronic medical ailments and met with her family physician for annual physical assessments. She had taken 11 tablets of quinine for nocturnal leg cramps over the course of 28 days before starting to notice mild peripheral edema, which subsequently progressed, leading to a family physician review...
March 7, 2018: Curēus
https://www.readbyqxmd.com/read/29734963/treatment-of-a-patient-with-task-specific-writing-tremor-using-magnetic-resonance-guided-focused-ultrasound
#14
Ying Meng, Suganth Suppiah, Nadia Scantlebury, Nir Lipsman, Michael L Schwartz
Task-specific dystonia is characterized by abnormal repetitive movements or postures in a specific body part that is triggered and ends with a task, such as writing. Failing medications, surgery, specifically disruption of key nuclei in the thalamus, can provide excellent symptomatic relief. Transcranial magnetic resonance (MR)-guided focused ultrasound is an emerging incision-less thermoablation technique. We describe MR-guided focused ultrasound tandem ablation of the ventral intermediate and ventralis oralis posterior nuclei in a 60-year-old patient with writer's cramp...
May 8, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29733841/abdominal-skeletal-muscle-activity-precedes-spontaneous-menstrual-cramping-pain-in-primary-dysmenorrhea
#15
Folabomi A Oladosu, Frank F Tu, Saaniya Farhan, Ellen F Garrison, Nicole D Steiner, Genevieve E Roth, Kevin M Hellman
BACKGROUND: Dysmenorrhea is a pervasive pain condition that affects 20-50% of reproductive-aged women. Distension of a visceral organ, such as the uterus, could elicit a viscero-motor reflex resulting in involuntary skeletal muscle activity and referred pain. Although referred abdominal pain mechanisms can contribute to visceral pain, the role of abdominal muscle activity has not yet been investigated within the context of menstrual pain. OBJECTIVE: The goal of this study is to determine if involuntary abdominal muscle activity precedes spontaneous episodes of menstrual cramping pain in dysmenorrheic women and if naproxen administration affects abdominal muscle activity...
May 4, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29732965/otilonium-bromide-a-drug-with-a-complex-mechanism-of-action
#16
Stefano Evangelista, Chiara Traini, Maria Giuliana Vannucchi
Otilonium bromide (OB) is a drug with spasmolytic activity belonging to quaternary ammonium derivatives and extensively used to treat patients affected by the irritable bowel syndrome (IBS). Thanks to its peculiar pharmacokinetic, OB concentrates in the large bowel wall and acts locally. From the pharmacodynamics point of view, OB is able to inhibit i) the main patterns of human colonic motility in vitro; ii) the contractility caused by excitatory motor neurons stimulation (pre-synaptic action) and iii) the contractility caused by the direct action of excitatory neurotransmitters (post-synaptic action)...
May 7, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29729556/effects-of-aromatherapy-on-dysmenorrhea-a-systematic-review-and-meta-analysis
#17
Ji-Ah Song, Mi-Kyoung Lee, Eunsil Min, Mi-Eun Kim, Geraldine Fike, Myung-Haeng Hur
OBJECTIVE: Menstrual pain is not a disease, but it is a problem that periodically makes women uncomfortable during menstrual cycles. There has been a continuing effort to alleviate menstrual cramps in the medical field. Aromatherapy, one of the alternative complementary therapies, has been used as a way to alleviate menstrual cramps, but there is still little evidence of how to use it. Therefore, in this study, we tried to find and provide the evidence of relieving effects of menstrual cramps...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29728995/relationship-between-fatigue-symptoms-and-subjective-and-objective-indicators-in-hemodialysis-patients
#18
Manhua Zuo, Jun Tang, Miaomiao Xiang, Qing Long, Jianping Dai, Xiuying Hu
PURPOSE: The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD). METHODS: Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods. RESULTS: A total of 511 patients were included in the study...
May 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29726732/the-prevalence-distribution-and-functional-importance-of-lower-limb-somatosensory-impairments-in-chronic-stroke-survivors-a-cross-sectional-observational-study
#19
Terry Gorst, Alison Rogers, Stewart C Morrison, Mary Cramp, Joanne Paton, Jenny Freeman, Jon Marsden
PURPOSE: To investigate the prevalence and distribution of lower limb somatosensory impairments in community dwelling chronic stroke survivors and examine the association between somatosensory impairments and walking, balance, and falls. METHODS: Using a cross sectional observational design, measures of somatosensation (Erasmus MC modifications to the (revised) Nottingham Sensory Assessment), walking ability (10 m walk test, Walking Impact Scale, Timed "Get up and go"), balance (Functional Reach Test and Centre of Force velocity), and falls (reported incidence and Falls Efficacy Scale-International), were obtained...
May 4, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29717197/effects-of-ngm282-an-fgf19-variant-on-colonic-transit-and-bowel-function-in-functional-constipation-a-randomized-phase-2-trial
#20
Ibironke Oduyebo, Michael Camilleri, Alfred D Nelson, Disha Khemani, Sara Linker Nord, Irene Busciglio, Duane Burton, Deborah Rhoten, Michael Ryks, Paula Carlson, Leslie Donato, Alan Lueke, Kathline Kim, Stephen J Rossi, Alan R Zinsmeister
OBJECTIVE: NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials in type 2 diabetes and primary biliary cholangitis, NGM282 was associated with dose-related abdominal cramping and diarrhea. We aimed to examine effects of NGM282 on colonic transit, stool frequency and consistency, hepatic BA synthesis (fasting serum C4), fecal fat, and BA in functional constipation (FC). METHODS: Two-dose NGM282 (1 and 6 mg, subcutaneously daily), parallel-group, randomized, placebo-controlled, 14-day study in patients with FC (Rome III criteria) and baseline colonic transit 24 h geometric center (GC) <3...
May 2, 2018: American Journal of Gastroenterology
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