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Ningning Zhou, Wei Yu, Suqin Tang, Jianping Wang, Clare Killikelly
Bereavement may trigger different psychological outcomes, such as prolonged grief disorder or post-traumatic growth. The relationship between these two outcomes and potential precipitators remain unknown. The current study aimed to identify classes of Chinese bereaved individuals based on prolonged grief symptoms and post-traumatic growth and to examine predictors for these classes. We used data from 273 Chinese individuals who lost a relative due to disease (92.3%), accident (4.4%) and other reasons (1.8%)...
June 6, 2018: Psychiatry Research
Hongqiao Fu, Ling Li, Winnie Yip
In 2012, the Chinese government launched a nationwide reform of county-level public hospitals with the goal of controlling the rapid growth of healthcare expenditure. The key components of the reform were the zero markup drug policy (ZMDP), which removed the previously allowed 15% markup for drug sales at public hospitals, and associated increases in fees for medical services. By exploiting the temporal and cross-sectional variations in the policy implementation and using a unique, nationally representative hospital-level dataset in 1880 counties between 2009 and 2014, we find that the policy change led to a reduction in drug expenditures, a rise in expenditures for medical services, and no measurable changes in total health expenditures...
June 18, 2018: Social Science & Medicine
Zhi-Cheng Deng, Wen-Zhu Jiang, Xiao-Dong Tang, Shuang-Hai Liu, Lei Qin, Hai-Xin Qian
BACKGROUND: The aim of this study was to investigate the long-term outcomes and perioperative outcomes of laparoscopic hepatectomy (LH) versus open hepatectomy (OH) for hepatocellular carcinoma (HCC) between well-matched patient groups. METHODS: We retrospectively reviewed data from 1535 hepatocellular carcinoma patients who underwent liver resection between January 2002 and December 2016 at two Chinese centres. Propensity score matching of patients in a ratio of 1:1 was conducted and 157 patients were matched...
June 20, 2018: International Journal of Surgery
Xu Jianping, Wei Kunhua, Zhang Guojun, Lei Lujing, Yang Dawei, Wang Wenle, Han Qiheng, Xia Yuan, Bi Yaqiong, Yang Min, Li Minhui
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Salvia is one of the largest genera of the Lamiaceae family. In China, about 40 Salvia species have been used as medicinal plants for treatment of various diseases, specifically hepatic and renal diseases and those of the cardiovascular and immune systems. AIM OF THIS REVIEW: This review aims to provide systematically organized information on the ethnopharmacology, phytochemistry, pharmacology, and toxicology of medicinal Salvia species in China to support their therapeutic potential in the treatment of human diseases...
June 20, 2018: Journal of Ethnopharmacology
Yan Zhang, Yi Jin, Carel Vereijken, Bernd Stahl, Hong Jiang
Breastfeeding rates remain low in China despite decades of efforts at improving breastfeeding practices. The study aimed to explore mothers' breastfeeding experience throughout the breastfeeding period and to understand their challenges and support service needs at each stage. Qualitative research methods, individual in-depth interviews and focus group discussions were carried out with mothers and people who played various roles regarding breastfeeding such as service provider, researcher and policy maker. Mothers' breastfeeding practices can be categorized into five stages...
June 20, 2018: Appetite
Yuan Wang, Xiaoyan Huang, Zengchun Ma, Yuguang Wang, Xiangmei Chen, Yue Gao
Ophiopogonin D (OPD) is the chief pharmacological active component of the traditional Chinese herbal prescription drug-Shenmai injection (SMI), which has been used to prevent and treat cardiovascular diseases. In the present study, we investigated whether OPD protectively relieve cardiac hypertrophy against inflammation via inhibiting the expression of NF-κB and examined whether cytochrome P450 2J3 (CYP2J3)was involved in this pathway. H9c2 cells were treated with Angiotensin II (Ang II). Hypertrophy in rat was induced by administration of Ang II infusion...
June 20, 2018: Biochemical and Biophysical Research Communications
Pan Zhuang, Qiyang Shou, Wenqiao Wang, Lilin He, Jun Wang, Jingnan Chen, Yu Zhang, Jingjing Jiao
SCOPE: To assess the associations of dietary linoleic acid (LA) and α-linolenic acid (ALA) with type 2 diabetes (T2D) risk in a population-based cohort and further explore the mechanism of action in a high-fat-diet induced obese (DIO) mouse model. METHODS AND RESULTS: The occurrence of T2D among 15,100 healthy Chinese adults from China Health and Nutrition Survey (CHNS, 1997-2011) were followed up for a median of 14 years. The relations of ALA and LA intakes with T2D risk were modified by BMI, with significant associations restricted to obese/overweight subjects...
June 23, 2018: Molecular Nutrition & Food Research
Duska Dragun, Aurélie Philippe
Angiotensin II type 1 receptor (AT1 R) is a classical G-protein-coupled-receptor (GPCR) displaying complex structure consisting of 7-transmembrane helices connected by intracellular and extracellular loops. Beside Angiotensin II binding within transmembrane sites and mechanically induced ligand free activation, AT1 R can be also activated by agonistic autoantibodies (AT1 R-Ab) recognizing conformational epitopes contained in the second extracellular loop. Direct pathophysiologic involvement of AT1 R-Abs is well established in several autoimmune contexts and organ transplantation (1)...
June 23, 2018: American Journal of Transplantation
Junhua Gong, Sirong He, Yao Cheng, Nansheng Cheng, Jianping Gong, Zhong Zeng
BACKGROUND: Postoperative pancreatic fistula is one of the most frequent and potentially life-threatening complications following pancreatic resections. Fibrin sealants are introduced to reduce postoperative pancreatic fistula by some surgeons. However, the use of fibrin sealants during pancreatic surgery is controversial. This is an update of a Cochrane Review last published in 2016. OBJECTIVES: To assess the safety, effectiveness, and potential adverse effects of fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery...
June 23, 2018: Cochrane Database of Systematic Reviews
Ye Bai, Shuang Qiu, Yan Li, Yong Li, Weijing Zhong, Meijuan Shi, Xiaojuan Zhu, Huiyi Jiang, Yaqin Yu, Yi Cheng, Yawen Liu
Autism spectrum disorder (ASD), as one of early-onset neurodevelopmental disorders, is characterized by the following symptoms, including repetitive and stereotyped behaviors, impairments in social interaction, and dysfunctions in communication. ASD afflicts ∼1.5% of children aged 8 years in America and ∼4.5‰ of children aged 0-6 years in China. Existing studies suggest that SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) is implicated in ASD. However, associations between SNPs in SHANK2 introns and ASD risk have been less investigated...
June 22, 2018: IUBMB Life
Muhammad Ismail Khan, Soyeon Choi, Muhammad Zahid, Habib Ahmad, Roshan Ali, Musharraf Jelani, Changsoo Kang
Palmoplantar keratoderma (PPK) is a rare group of excessive skin disorder characterized by thickness over the palms and soles. The striate palmoplantar keratoderma (PPKS) is a form in which hyperkeratotic lesions are restricted to the pressure regions extending longitudinally in the length of each finger to the palm. Dominantly inherited mutations in genes including desmoglein 1, desmoplakin and keratin 1 have been suggested as genetic causes of PPKS. In this study, we investigated a three-generation Pakistani family segregating PPKS phenotype in autosomal dominant fashion to identify genetic cause in this family...
July 2018: Genes & Genomics
Wei Wang, Huai Wang, Hui Tang, Jia Gan, Changgeng Shi, Qing Lu, Donghui Fang, Jun Yi, Maozhong Fu
There are abundant cattle breeds/populations in China, and the systematic discovery of genomic variants is essential for performing the marker assisted selection and conservation of genetic resources. In the present study, we employed whole transcriptome sequencing (RNA-Seq) technology for revealing genetic structure among six Chinese cattle populations according to transcriptome-wide SNPs and gene expression. A total of 68,094 variants consisting of 61,754 SNPs and 6340 InDels were detected and widely distributed among all chromosomes, by which the clear patterns of population structures were revealed...
July 2018: Genes & Genomics
Zhishan Hu, Juan Zhang, Tania Alexandra Couto, Shiyang Xu, Ping Luan, Zhen Yuan
In this study, functional near-infrared spectroscopy (fNIRS) was used to examine the brain activation and connectivity in occipitotemporal cortex during Chinese character recognition (CCR). Eighteen healthy participants were recruited to perform a well-designed task with three categories of stimuli (real characters, pseudo characters, and checkerboards). By inspecting the brain activation difference and its relationship with behavioral data, the left laterality during CCR was clearly identified in the Brodmann area (BA) 18 and 19...
June 22, 2018: Brain Topography
Ching Chu Sun, Peter Hendrix, Jianqiang Ma, Rolf Harald Baayen
We present the Chinese Lexical Database (CLD): a large-scale lexical database for simplified Chinese. The CLD provides a wealth of lexical information for 3913 one-character words, 34,233 two-character words, 7143 three-character words, and 3355 four-character words, and is publicly available through . For each of the 48,644 words in the CLD, we provide a wide range of categorical predictors, as well as an extensive set of frequency measures, complexity measures, neighborhood density measures, orthography-phonology consistency measures, and information-theoretic measures...
June 22, 2018: Behavior Research Methods
Cong Lu, Li-Xi Li, Hai-Lin Dong, Qiao Wei, Zhi-Jun Liu, Wang Ni, Aaron D Gitler, Zhi-Ying Wu
Hereditary spastic paraplegia (HSP) is a heterogeneous group of neurodegenerative diseases characterized by progressive weakness and spasticity of lower limbs. To clarify the genetic spectrum and improve the diagnosis of HSP patients, targeted next-generation sequencing (NGS) was applied to detect the culprit genes in 55 Chinese HSP pedigrees. The classification of novel variants was based on the American College of Medical Genetics and Genomics (ACMG) standards and guidelines. Patients remaining negative following targeted NGS were further screened for gross deletions/duplications by multiplex ligation-dependent probe amplification (MLPA)...
July 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Chao Zhou, LiJuan Liu, Jing Zhuang, JunYu Wei, TingTing Zhang, ChunDi Gao, Cun Liu, HuaYao Li, HongZong Si, ChangGang Sun
BACKGROUND The method of multiple targets overall control is increasingly used to predict the main active ingredient and potential target group of Chinese traditional medicines and to determine the mechanisms involved in their curative effects. Qingdai is the main traditional Chinese medicine used in the treatment of chronic myelogenous leukemia (CML), but the complex active ingredients and antitumor targets in treatment of CML have not been clearly defined in previous studies. MATERIAL AND METHODS We constructed a protein-protein interaction network diagram of CML with 638 nodes (proteins) and 1830 edges, based on the biological function of chronic myelocytic leukemia by use of Cytoscape, and we determined 19 key gene nodes in the CML molecule by network topological properties analysis in a data bank...
June 23, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Yan Zhang, Shan Lu, Yadong Niu, Liang Zhang
OBJECTIVE: To identify the characteristics of high-cost (HC) patients and the determinants of the annual medical expenditures of Chinese rural residents. METHODS: Medical expenditure clustering was performed by Lorentz curve and Gini index. T and X2 tests were performed to identify the characteristics of the respondents, and a multilevel regression model examined the determinants of their annual medical expenditures. DESIGN: A cluster sampling study was performed to identify those residents who availed healthcare services and to assign them to HC (top 5%), moderate-cost (top 30%) and low-cost (others) groups based on their annual medical expenditures...
June 22, 2018: BMJ Open
Guohua Zheng, Yuhui Zheng, Zhenyu Xiong, Bingzhao Ye, Jing Tao, Lidian Chen
INTRODUCTION: Poststroke cognitive impairment is one of the most common complications in stroke survivors, and >65% of these patients suffer from cognitive impairment at 12 months following onset, which strongly affects the rehabilitation of their motor function and quality of life. Therefore, it is important to improve the cognitive ability of stroke survivors. As an important component of traditional Chinese Qigong exercises, characterised by the coordination of mind and body with a low exercise intensity, Baduanjin has the potential benefit of improving cognitive ability for patients who had a stroke with cognitive impairment...
June 22, 2018: BMJ Open
Nan-Ying Yu, Shao-Hsia Chang
This study proposed a new technology to assess the accuracy of Chinese handwriting by comparing every stroke movement between a template model and a handwritten script. It tested the feasibility of a computerized evaluation in the parameterization of the handwriting deterioration caused by impaired cognitive function. This study recruited 22 participants with Alzheimer's disease (AD) and 14 with amnestic mild cognitive impairment (aMCI); 18 age- and gender-matched healthy elderly individuals made up the health control...
June 19, 2018: Human Movement Science
Lulu Kang, Yu Wang, Xiaolan Gao, Wenjuan Qiu, Jun Ye, Lianshu Han, Xuefan Gu, Huiwen Zhang
BACKGROUND: Gaucher disease (GD) is one of the most common lysosomal storage diseases resulting from a deficiency of glucocerebrosidase. Three main types have been described, with type 2 being the most rare and severe form. Here we investigated the clinical symptoms and mutation spectrum in 20 unrelated type 2 GD patients. METHOD: The diagnosis of GD was based on the acid β-glucocerebrosidase (GBA) enzyme activity and direct sequencing of the GBA gene. GBA activity was measured in leukocytes and the GBA gene was amplified by a polymerase chain reaction (PCR)...
June 19, 2018: Brain & Development
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