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https://www.readbyqxmd.com/read/28239990/full-length-sequences-of-3-hla-b-56-alleles-b-56-01-01-01-b-56-03-and-b-56-04-confirmed-by-cloning-and-sequencing
#1
Z Li, H-Y Zou
Full-length sequences of HLA-B*56:01:01:01, B*56:03 and B*56:04, confirmed by cloning and sequencing in Chinese donors.
February 26, 2017: HLA
https://www.readbyqxmd.com/read/28239915/rapid-analysis-of-corni-fructus-using-paper-spray-mass-spectrometry
#2
Yuan Guo, Zhixin Gu, Xuemei Liu, Jingjing Liu, Ming Ma, Bo Chen, Liping Wang
INTRODUCTION: Paper spray-mass spectrometry (PS-MS) is a kind of ambient MS technique for the rapid analysis of samples. Corni fructus has been widely used in traditional Chinese compound preparations and healthy food. However, a number of counterfeits of Corni fructus, such as Crataegi fructus, Lycii fructus, and grape skin are illegally sold in crude herb markets. Therefore, the development of a rapid and high-throughput quality evaluation method is important for ensuring the effectiveness and safety of the crude materials of Corni fructus...
February 26, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28239907/effects-of-oral-%C3%AE-lipoic-acid-administration-on-body-weight-in-overweight-or-obese-subjects-a-crossover-randomized-double-blind-placebo-controlled-trial
#3
Nong Li, Weili Yan, Xiaojuan Hu, Yongdi Huang, Fugang Wang, Weiguo Zhang, Qian Wang, Xiaoling Wang, Kehong Sun
OBJECTIVE: Alpha-lipoic acid (ALA) has shown beneficial properties on diabetes and obesity. The aim of this study was to examine the effects of oral ALA on body weight in subjects with overweight or obese. DESIGN: Single-centre, randomized, double-blind, crossover controlled study. PARTICIPANTS: A total of 166 subjects of Chinese Han ethnicity with a BMI ≥25 kg/m(2) were screened and 103 subjects fulfilled the study requirements, in terms of informed consent and participation to the study...
January 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28239527/uric-acid-is-associated-with-vascular-dementia-in-chinese-population
#4
Yuzhen Xu, Qian Wang, Ruiting Cui, Kaili Lu, Yunlin Liu, Yuwu Zhao
OBJECTIVE: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD. MATERIALS AND METHODS: There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239516/nonmotor-symptoms-in-primary-adult-onset-cervical-dystonia-and-blepharospasm
#5
Jing Yang, Na Shao, Wei Song, Qianqian Wei, Ruwei Ou, Ying Wu, Hui-Fang Shang
BACKGROUND: The nature and frequency of nonmotor symptoms in primary adult-onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown. METHODS: Hamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE-R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult-onset dystonia (60 with BSP and 60 with CD) and 60 age-, sex-, and education level- matched healthy controls (HCs)...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239441/quality-and-labeling-information-of-moringa-oleifera-products-marketed-for-hiv-infected-people-in-zimbabwe
#6
Tsitsi Grace Monera-Penduka, Zvinji Tella Jani, Charles Chiedza Maponga, Josephine Mudzengi, Gene D Morse, Charles Fungai Brian Nhachi
Labeling information and quality of marketed Moringa oleifera products were assessed. Personnel in 60 pharmacies and 11 herbal shops were interviewed about the sources, dosages, indications and counseling information of Moringa oleifera products. Content analysis of written information provided on Moringa oleifera products was also done. Three samples of Moringa from popular sources were acquired to determine heavy metal content and microbial contamination. The results were compared to specified limits in the European and Chinese pharmacopeia, World Health Organization guidelines and Bureau of Indian Standards...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28239387/comprehensive-analysis-of-the-cdpk-snrk-superfamily-genes-in-chinese-cabbage-and-its-evolutionary-implications-in-plants
#7
Peng Wu, Wenli Wang, Weike Duan, Ying Li, Xilin Hou
The CDPK-SnRK (calcium-dependent protein kinase/Snf1-related protein kinase) gene superfamily plays important roles in signaling pathways for disease resistance and various stress responses, as indicated by emerging evidence. In this study, we constructed comparative analyses of gene structure, retention, expansion, whole-genome duplication (WGD) and expression patterns of CDPK-SnRK genes in Brassica rapa and their evolution in plants. A total of 49 BrCPKs, 14 BrCRKs, 3 BrPPCKs, 5 BrPEPRKs, and 56 BrSnRKs were identified in B...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28239162/time-trends-and-factors-in-body-mass-index-and-obesity-among-children-in-china-1997-to-2011
#8
H Wang, H Xue, S Du, J Zhang, Y Wang, B Zhang
INTRODUCTION: Research on the shift in children's Body Mass Index (BMI) distribution is limited and conditional mean models used in the previous research have limitations in capturing cross-distribution variations in effects. The objectives are to analyze the shift in Chinese children's BMI distribution and to test the associations between BMI distribution and other factors. METHODS: We analyzed data collected from children 7-17 years old from the China Health and Nutrition Survey (CHNS) conducted in 1997, 2000, 2004, 2006, 2009 and 2011, from 2814 participants with 6799 observations...
February 27, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28239159/sarsasapogenin-aa13-inhibits-lps-induced-inflammatory-responses-in-macrophage-cells-in-vitro-and-relieves-dimethylbenzene-induced-ear-edema-in-mice
#9
Dong Dong, Nan-Nan Zhou, Rui-Xuan Liu, Jia-Wei Xiong, Hui Pan, Si-Qi Sun, Lei Ma, Rui Wang
Sarsasapogenin-AA13 (AA13) is a novel synthetic derivative of sarsasapogenin extracted from the Chinese herb Rhizoma Anemarrhenae. In this study we investigated the effects of AA13 on lipopolysaccharide (LPS)-induced production of inflammatory factors in macrophage cells and the anti-inflammatory activity of AA13 in an inflammatory model of dimethylbenzene-induced ear edema. Macrophage cells (RAW264.7 cells and mouse peritoneal macrophages) were exposed to LPS (1 μg/mL); pretreatment with AA13 (5-20 μmol/L) dose-dependently inhibited LPS-induced production of NO, TNF-α and PGE2, and LPS-stimulated expression levels of COX-2 and iNOS...
February 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28239058/a-nuclear-magnetic-resonance-spectroscopy-approach-to-discriminate-the-geographic-origin-of-roasted-asian-sesame-oils
#10
Gyungsu Jin, Jeongeun Kim, Yunhee Lee, Jinyeong Kim, Casimir C Akoh, Hyang Sook Chun, Sangdoo Ahn, Byung Hee Kim
The aim of this study was to discriminate the geographic origin of Korean, Chinese, and Indian sesame oils distributed in Korea using (1)H NMR spectroscopy in combination with canonical discriminant analysis (CDA). (1)H NMR spectra were obtained from 84 roasted oil samples prepared from 51 Korean, 19 Chinese, and 14 Indian sesame seeds. The integration values of 26 peaks observed in the NMR spectra were determined and normalized on the basis of the peak derived from the terminal CH3 of the fatty acids (0.7446-1...
February 24, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28238935/tryptophan-and-purine-metabolites-are-consistently-upregulated-in-the-urinary-metabolome-of-patients-diagnosed-with-gestational-diabetes-mellitus-throughout-pregnancy-a-longitudinal-metabolomics-study-of-chinese-pregnant-women-part-2
#11
Kai P Law, Ting-Li Han, Xun Mao, Hua Zhang
BACKGROUND: Gestational diabetes mellitus (GDM) is a pathological state of glucose intolerance associated with adverse pregnancy outcomes and an increased risk of developing maternal type 2 diabetes later in life. The mechanisms underlying GDM development are not fully understood. We examined the pathophysiology of GDM through comprehensive metabolic profiling of maternal urine, using participants from a longitudinal cohort of normal pregnancies and pregnancies complicated by GDM. METHODS: Based on ultra-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry, an untargeted metabolomics study was performed to explore the differences in the urinary metabolome of GDM cases and healthy controls over the course of pregnancy...
February 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28238880/analysis-on-the-expression-and-function-of-a-chicken-type-and-goose-type-lysozymes-in-chinese-giant-salamanders-andrias-davidianus
#12
Hui Yang, Ranran Liu, Dan Cui, Haixia Liu, Dongmei Xiong, Xiaolin Liu, Lixin Wang
Lysozymes as an important immune factor, play vital roles in innate immune response against pathogen infection. In the present study, one c-type and g-type lysozymes were identified from Chinese giant salamander (Andrias davidianus). They shared highly conserved structural features with lysozymes from other species. Spatial expression analysis revealed that AdlysC transcript was most abundant in liver and stomach, and least in muscle and brain. In contrast, the expression level of AdlysG was most abundant in liver and least in muscle and skin...
February 23, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28238827/rhizoma-smilacis-glabrae-inhibits-pathogen-induced-upper-genital-tract-inflammation-in-rats-through-suppression-of-nf-%C3%AE%C2%BAb-pathway
#13
Wei Zou, Hougang Zhou, Jian Hu, Li Zhang, Qiue Tang, Xiaoke Wen, Zuoqi Xiao, Wei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Smilacis Glabrae (RSG) is traditionally used to treat gynecological disease, which is simply recorded in Chinese Pharmacopoeia. However, whether it has effect on upper genital tract inflammation (UGTI) is unclear. AIM OF THE STUDY: To evaluate the pharmacological effect of RSG on UGTI in rats and analyze its phytochemistry characteristics. MATERIALS AND METHODS: The substances in RSG extract was qualified by LC-Q-TOF-MS method, and 11 substances were further quantified...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28238555/prediction-of-five-year-all-cause-mortality-in-chinese-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study
#14
Eric Yuk Fai Wan, Daniel Yee Tak Fong, Colman Siu Cheung Fung, Esther Yee Tak Yu, Weng Yee Chin, Anca Ka Chun Chan, Cindy Lo Kuen Lam
AIMS: This study aimed to develop and validate an all-cause mortality risk prediction model for Chinese primary care patients with type 2 diabetes mellitus(T2DM) in Hong Kong. METHODS: A population-based retrospective cohort study was conducted on 132,462 Chinese patients who had received public primary care services during 2010. Each gender sample was randomly split on a 2:1 basis into derivation and validation cohorts and was followed-up for a median period of 5years...
February 2, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28238496/prevalence-of-polycystic-ovary-syndrome-in-chinese-obese-women-of-reproductive-age-with-or-without-metabolic-syndrome
#15
Peiwen Liang, Liuqing Xi, Juan Shi, Wanyu Li, Shaoqian Zhao, Yuying Deng, Rui Wang, Yingkai Sun, Bin Gu, Lihui Yuan, Yifei Zhang, Weiqiong Gu, Weiqing Wang, Jie Hong
OBJECTIVE: To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age. DESIGN: Cross-sectional clinical study. SETTING: Tertiary hospital. PATIENT(S): We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality...
February 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28238495/maternal-common-variant-rs2305957-spanning-plk4-is-associated-with-blastocyst-formation-and-early-recurrent-miscarriage
#16
Qian Zhang, Guangyu Li, Lei Zhang, Xiaohe Sun, Dandan Zhang, Juanjuan Lu, Jinlong Ma, Junhao Yan, Zi-Jiang Chen
OBJECTIVE: To investigate whether the common variant rs2305957 spanning PLK4 (Polo-like kinase 4) confers risk to embryo development in Northern Chinese Han (CHN) women. DESIGN: Genetic association study. SETTING: University hospital. PATIENT(S): A total of 2,015 infertile women who underwent in vitro fertilization (IVF), 530 women with early recurrent miscarriage (ERM), and 600 fertile control women in the CHN population...
February 23, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28238390/electro-clinical-etiological-associations-of-epilepsia-partialis-continua-in-57-chinese-children
#17
Hui Li, Jiao Xue, Ping Qian, Yuehua Zhang, Xinhua Bao, Xiaoyan Liu, Zhixian Yang
OBJECTIVE: Epilepsia partialis continua (EPC) was one type of focal status epilepticus. The aim of this study was to analyze the clinical and electroencephalography (EEG) characteristics, and outcome of 57 child-onset patients with EPC according to different etiologies, and further explore the electro-clinical-etiological associations. METHODS: We retrospectively reviewed 57 children diagnosed with EPC in our department over last ten years. Etiology, clinical and EEG data, and outcome were categorized and analyzed...
February 18, 2017: Brain & Development
https://www.readbyqxmd.com/read/28238380/organochlorine-pesticide-concentrations-in-pooled-serum-of-people-in-different-age-groups-from-five-chinese-cities
#18
Qinghua Wang, Haodong Yuan, Jun Jin, Peng Li, Yulong Ma, Ying Wang
Organochlorine pesticides (OCPs) were determined in human serum samples pooled by donor age (≥60, 50-59, 40-49, 30-39, and 20-29y). The pooled samples were supplied by hospitals in five Chinese cities, Yitong (Jilin Province), Weifang (Shandong Province), Ganzi (Sichuan Province), Huaihua (Hunan Province), and Lingshui (Hainan Province). p,p'-Dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), β-hexachlorocyclohexane (HCH), and endosulfan I were the dominant OCPs in the serum samples. The total OCP concentrations and individual concentrations of p,p'-DDE, HCB, and β-HCH were relatively high compared with concentrations that have been found in other parts of the world...
February 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28238301/the-impact-of-hemocoagulase-for-improvement-of-coagulation-and-reduction-of-bleeding-in-fracture-related-hip-hemiarthroplasty-geriatric-patients-a-prospective-single-blinded-randomized-controlled-study
#19
Meiguang Qiu, Xuming Zhang, Hongru Cai, Zhixian Xu, Hao Lin
BACKGROUND: Uncontrolled bleeding is associated with poor outcomes and mortality in geriatric patients undergoing hemiarthroplasty. Hemocoagulase agkistrodon is a hemocoagulative, anti-hemorrhagic enzyme complex from Deinagkistrodon acutus snake venom. This study aimed to investigate the efficacy of hemocoagulase agkistrodon on coagulation and bleeding outcomes in fracture-related hemiarthroplasty. PATIENTS AND METHODS: This was a prospective, single-blinded, randomized controlled trial carried out between October 2013 and September 2014 in 96 geriatric patients undergoing hemiarthroplasty for unilateral femoral neck fracture...
November 27, 2016: Injury
https://www.readbyqxmd.com/read/28238162/genetic-analysis-of-fgf20-in-chinese-patients-with-parkinson-s-disease
#20
Xiao-Yi Sun, Ling Wang, Lan Cheng, Nan-Nan Li, Zhong-Jiao Lu, Jun-Ying Li, Rong Peng
Sequence variants in fibroblast growth factor 20 (FGF20) have been reported to be associated with Parkinson's disease (PD). We genotyped the rs591323 variant in a total of 2220 Han Chinese subjects, including 1051 patients with sporadic PD and 1169 controls, to investigate the association between rs591323 and the risk of PD. In addition, we also conducted a stratified analysis according to age at onset of PD and compared the clinical characteristics of AA + AG subjects with GG subjects. In this study, we confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0...
February 25, 2017: Neurological Sciences
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