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https://www.readbyqxmd.com/read/29224258/progressive-osseous-heteroplasia-in-a-chinese-infant-and-a-novel-mutation-in-the-gnas-gene
#1
Shi-De Zhang, Zhuang-Li Xie, Ke-Qing Zhang, Karina Nht, Jing-Jun Zhao
Progressive osseous heteroplasia(POH,OMIM 166350) is a rare inherited disease that begins with skin ossification and proceeds into the deeper connective tissues. Most cases of POH are caused by heterozygous inactivating mutations of GNAS gene. Herein, we report a new sporadic case of atypical POH and its underlying genetic basis. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224080/anemia-and-iron-status-among-different-body-size-phenotypes-in-chinese-adult-population-a-nation-wide-health-and-nutrition-survey
#2
Jiang Li, Cheng Xiao, Hui Yang, Yun Zhou, Rui Wang, Yongtong Cao
Previous studies have shown that there is a controversial relationship between iron homeostasis and obesity. This study aims to explore the relationship of anemia and iron status with different body size phenotypes in adult Chinese population. Using information on iron status-related parameters and lifestyle data from 8462 participants of the 2009 wave of China Health and Nutrition Survey (2009 CHNS), we performed multivariable logistic regression analyses to estimate the odds ratios (ORs) for the risk of anemia and iron parameters according to different body size phenotypes...
December 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29224024/association-of-the-tg-hdl-c-and-non-hdl-c-hdl-c-ratios-with-chronic-kidney-disease-in-an-adult-chinese-population
#3
Jia Wen, Yiyin Chen, Yun Huang, Yao Lu, Xing Liu, Honghao Zhou, Hong Yuan
BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223893/biogeographic-distribution-of-bacterial-archaeal-and-methanogenic-communities-and-their-associations-with-methanogenic-capacity-in-chinese-wetlands
#4
Jie Zhang, Shuo Jiao, Yahai Lu
Natural wetlands and anthropogenic paddy fields are the dominant biogenic sources of atmospheric methane emission which have been speculated as the most probable sources for the increase of post-2006 atmospheric methane. Regional differences in CH4 emission is possibly due to microbial biogeographic distribution. Here we collected soils from 19 wetlands from different regions in China. The methane production capacity (MPC) was measured for each soil samples and varied from 1.11 to 841.94mg/kg dry soil. High throughput sequencing was employed to investigate the diversity and composition of bacterial, archaeal and methanogenic communities...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223588/-9-o-%C3%AE-l-rhamnopyranosyl-lyoniresinol-from-lespedeza-cuneata-suppresses-ovarian-cancer-cell-proliferation-through-induction-of-apoptosis
#5
Jiwon Baek, Dahae Lee, Tae Kyoung Lee, Ji Hoon Song, Ju Sung Lee, Seong Lee, Sang-Woo Yoo, Ki Sung Kang, Eunjung Moon, Sanghyun Lee, Ki Hyun Kim
Lespedeza cuneata (Dum. Cours.) G. Don. (Fabaceae), known as Chinese bushclover or sericea lespedeza, has been used in traditional medicine to treat diabetes, hematuria, and insomnia, and it has been reported that bioactive compounds from L. cuneata possess various pharmacological properties. However, there has been no study to determine the active compounds from L. cuneata with potential activity against ovarian cancer. This study aimed to isolate cytotoxic compounds from L. cuneata and identify the molecular mechanisms underlying the apoptosis pathway in ovarian cancer cells...
November 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29223458/determination-of-zinc-oxide-content-of-mineral-medicine-calamine-using-near-infrared-spectroscopy-based-on-miv-and-bp-ann-algorithm
#6
Xiaodong Zhang, Long Chen, Yangbo Sun, Yu Bai, Bisheng Huang, Keli Chen
Near-infrared (NIR) spectroscopy has been widely used in the analysis fields of traditional Chinese medicine. It has the advantages of fast analysis, no damage to samples and no pollution. In this research, a fast quantitative model for zinc oxide (ZnO) content in mineral medicine calamine was explored based on NIR spectroscopy. NIR spectra of 57 batches of calamine samples were collected and the first derivative (FD) method was adopted for conducting spectral pretreatment. The content of ZnO in calamine sample was determined using ethylenediaminetetraacetic acid (EDTA) titration and taken as reference value of NIR spectroscopy...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29223397/-borneol-suppresses-conditioned-fear-recall-and-anxiety-like-behaviors-in-mice
#7
Bo Cao, Huan-Yu Ni, Jun Li, Ying Zhou, Xin-Lan Bian, Yan Tao, Cheng-Yun Cai, Cheng Qin, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29223366/therapeutic-efficacy-and-safety-of-umbilical-cord-mesenchymal-stem-cell-transplantation-for-liver-cirrhosis-in-chinese-population-a-meta-analysis
#8
Weiwei Sang, Benji Lv, Ke Li, Yan Lu
BACKGROUND AND OBJECTIVE: Mesenchymal stem cells transfusion has been considered as a promising option for liver cirrhosis (LC). The aim of this study was to systematically evaluate the efficacy and safety of umbilical cord mesenchymal stem cells (UMSC) combined with traditional supportive therapy (TST) for the treatment of patients with LC. METHODS: Data was extracted from clinical trials published on Web of Science, PubMed, EMBASE, Cochrane Library, Wanfang and CNKI database...
December 6, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29223356/isolation-of-novel-microsatellite-markers-and-their-application-for-genetic-diversity-and-parentage-analyses-in-sika-deer
#9
Wanyun Yang, Junjun Zheng, Boyin Jia, Haijun Wei, Guiwu Wang, Fuhe Yang
Every part of the sika deer (Cervus nippon) body is valuable traditional Chinese medicine. And sika deer is the most important semi-domestic medicinal animal that is widely bred in Jilin province northeast of China. But few studies had been conducted to characterize the microsatellite markers derived from sika deer. We firstly used IlluminaHiSeq™2500 sequencing technology obtained 125Mbp genomic data of sika deer. Using microsatellite identification tool (MISA), 22,479 microsatellites were identified. From these data, 100 potential primers were selected for further polymorphic validation, finally, 76 primer pairs were successfully amplified and 29 primer pairs were found to be obvious polymorphic in 8 different individuals...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29223348/distinctive-binding-properties-of-the-negative-allosteric-modulator-3h-sb269-652-at-recombinant-dopamine-d3-receptors
#10
Irene Fasciani, Ilaria Pietrantoni, Mario Rossi, Clotilde Mannoury la Cour, Gabriella Aloisi, Francesco Marampon, Marco Scarselli, Mark J Millan, Roberto Maggio
Recently, employing radioligand displacement and functional coupling studies, we demonstrated that SB269,652 (N-[(1r,4r)-4-[2-(7-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-1H-indole-2-carboxamide) interacts in an atypical manner with dopamine D3 receptor displaying a unique profile reminiscent of a negative allosteric ligand. Here, we characterized the binding of radiolabelled [3H]SB269,652 to human dopamine D3 receptor stably expressed in Chinese Hamster Ovary cells. Under saturating conditions, SB269,652 showed a KD value of ≈ 1nM...
December 6, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223049/determination-of-blood-concentrations-of-main-active-compounds-in-zi-cao-cheng-qi-decoction-and-their-total-plasma-protein-binding-rates-based-on-hollow-fiber-liquid-phase-microextraction-coupled-with-high-performance-liquid-chromatography
#11
Miaomiao Li, Xuan Chen, Shuang Hu, Runqin Wang, Xiaoli Peng, Xiaohong Bai
Oil-in-salt hollow fiber liquid phase microextraction coupled with high performance liquid chromatography ultraviolet detection (HPLC-UV) was developed for determination of the blood concentrations of the main active compounds, hesperidin, honokiol, shikonin, magnolol, emodin and β,β'-dimethylacrylshikonin, after oral administration of Zi-Cao-Cheng-Qi decoction (ZCCQD) and their total plasma protein binding rates. In the procedure, a hollow fiber segment was immersed in organic solvent to fill the solvent in the fiber lumen and wall pore, and then the fiber was immersed into sodium chloride solution to cover a thin salt membrane on the fiber wall pore filling organic solvent...
December 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29223013/effectiveness-of-flipped-classrooms-in-chinese-baccalaureate-nursing-education-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Rujun Hu, Huiming Gao, Yansheng Ye, Zhihong Ni, Ning Jiang, Xiaolian Jiang
BACKGROUND: In recent years, the flipped classroom approach has been broadly applied to nursing courses in China. However, a systematic and quantitative assessment of the outcomes of this approach has not been conducted. OBJECTIVE: The purpose of the meta-analysis is to evaluate the effectiveness of the flipped classroom pedagogy in Chinese baccalaureate nursing education. DESIGN: Meta-analysis of randomized controlled studies. DATA SOURCE: All randomized controlled trials relevant to the use of flipped classrooms in Chinese nursing education were retrieved from the following databases from their date of inception through September 23, 2017: PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, the China National Knowledge Infrastructure, the Wanfang Database, and the Chinese Scientific Journals Database...
November 29, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29222897/platelet-related-cytokines-among-normal-body-mass-index-overweight-and-obese-malaysians
#13
Nasrin Riyahi, Eusni Rahayu Mohd Tohit, Subashini C Thambiah, Zuriati Ibrahim
BACKGROUND AND OBJECTIVES: Recent studies have reported that obesity is associated with platelet activation and systemic inflammation. Malaysia has the highest prevalence of obesity, hence, this research is performed to evaluate the development of low-grade inflammation and platelet activation, measured using soluble CD40 ligand (sCD40L) and soluble P-selectin (sP-sel), and to determine their association with obesity. In addition, we assessed the mean platelet volume (MPV) and platelet count (PLT), which are novel parameters consistently associated with obesity...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222886/salivary-cariogenic-bacteria-counts-are-associated-with-obesity-in-student-women-at-a-malaysian-university
#14
Wey-Zheng Yeo, Sheng-Pei Lim, Yee-How Say
BACKGROUND AND OBJECTIVES: The counts of cariogenic bacteria lactobacilli and mutans streptococci have been studied and correlated with sugar intake. This study was to investigate the association between salivary lactobacilli and mutans streptococci counts with sweet food eating behavior and sweet sensitivity among 120 Malaysian women (101 ethnic Chinese, 19 ethnic Indians), while taking into account anthropometric and menstruation variables. METHODS AND STUDY DESIGN: Demographics, anthropometric measurements and menstrual history were taken...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222883/the-geriatric-nutritional-risk-index-predicts-mortality-in-nonagenarians-and-centenarians-receiving-home-care
#15
Hui Wang, Shan Hai, Yan Zhou, Ping Liu, Bi-Rong Dong
BACKGROUND AND OBJECTIVES: The increasing prevalence of malnutrition in old people is related to the risk of illness and death. A number of screening tools to detect malnutrition have been used in the elderly to assess nutritional status and predict prognosis. The aim of the present study was to investigate the ability of the Geriatric Nutritional Risk Index (GNRI) to assess nutritional status and predict mortality in very old home-care people by using a cross-sectional study of Chinese older people aged 90-105 years...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222882/relative-validity-of-an-indirect-calorimetry-device-for-measuring-resting-energy-expenditure-and-respiratory-quotient
#16
Xi Wang, Yuan Wang, Zenghui Ding, Guangbei Cao, Fusong Hu, Yining Sun, Zuchang Ma, Duoqi Zhou, Benyue Su
BACKGROUND AND OBJECTIVES: Resting energy expenditure (REE) and respiratory quotient (RQ) are important for optimal nutritional care. The purpose of this study was to assess the accuracy and repeatability of an indirect calorimetry device (IIM-IC-100) in the measurement of REE and RQ in healthy Chinese adults. METHODS AND STUDY DESIGN: A total of 38 healthy adults (19 male and 19 female) aged 18-52 years (25±6 years) were enrolled in this study. REE and RQ were measured by IIM-IC-100 and by VO2000, alternately and in duplicate...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222811/association-of-hla-dqb1-03-03-with-pityriasis-rosea-in-chinese-patients
#17
L-Y Fu, C-C Xu, X-D Zheng, G Chen, J Zhu, P-G Wang
BACKGROUND: The association of human leucocyte antigen (HLA) with a variety of diseases has been described, especially with various autoimmune diseases. However, there are few studies on the association between HLA and pityriasis rosea (PR). AIM: To investigate the relevance of HLA II alleles with the development of PR. METHODS: Typing for HLA-DRB1, HLA-DQA1 and HLA-DQB1 typing was performed in 55 patients with PR and 90 healthy controls (HCs), using sequence-based typing (SBT) and PCR with sequence-specific primers (PCR-SSP), respectively...
December 8, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29222627/pediatric-asthma-management-in-china-current-and-future-challenges
#18
Xiaojian Zhou, Jianguo Hong
The purpose of this report was to review the state of asthma diagnosis and treatment in China and to examine challenges in achieving earlier diagnosis and treatment. The prevalence of asthma in children in China has increased over past decades, and data published in 2013 indicated a prevalence of 3.0% in children aged 0-14 years. Although this prevalence has increased, the percentage of children with acute asthma attacks decreased from 86% in 2000 to 77% in 2010, and the frequency of hospitalizations for asthma attacks decreased from 54...
December 8, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29222420/effect-of-high-pressure-treatment-and-short-term-storage-on-changes-in-main-volatile-compounds-of-chinese-liquor
#19
Menglong Xu, Songming Zhu, Hosahalli S Ramaswamy, Yong Yu
Changes in main volatile compounds of Chinese liquor after high pressure (HP) treatment and following short term storage were investigated. 400 MPa-15 min & 400 MPa-30 min were applied to young liquor. Results from gas chromatography (GC) analysis revealed decreasing trends in alcohols, aldehydes and ethyl acetate immediately after HP treatments, which was in consistent with those in natural aging process; but no significant change was found in acids. However, differences in main volatile compounds between young liquor and pressurized liquors disappeared after two to six months of storage...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222134/workplace-violence-psychological-stress-sleep-quality-and-subjective-health-in-chinese-doctors-a-large-cross-sectional-study
#20
Tao Sun, Lei Gao, Fujun Li, Yu Shi, Fengzhe Xie, Jinghui Wang, Shuo Wang, Shue Zhang, Wenhui Liu, Xiaojian Duan, Xinyan Liu, Zhong Zhang, Li Li, Lihua Fan
BACKGROUND: Workplace violence (WPV) against healthcare workers is known as violence in healthcare settings and referring to the violent acts that are directed towards doctors, nurses or other healthcare staff at work or on duty. Moreover, WPV can cause a large number of adverse outcomes. However, there is not enough evidence to test the link between exposure to WPV against doctors, psychological stress, sleep quality and health status in China. OBJECTIVES: This study had three objectives: (1) to identify the incidence rate of WPV against doctors under a new classification, (2) to examine the association between exposure to WPV, psychological stress, sleep quality and subjective health of Chinese doctors and (3) to verify the partial mediating role of psychological stress...
December 7, 2017: BMJ Open
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