Alyssa Brodeur, Vincent Roy, Lydia Touzel-Deschênes, Stéphanie Bianco, Arnaud Droit, Julie Fradette, Jean Ruel, François Gros-Louis
Calcific aortic valve disease (CAVD) is characterized by the fibrosis and mineralization of the aortic valve, which leads to aortic stenosis and heart failure. At the cellular level, this is due to the osteoblastic-like differentiation of valve interstitial cells (VICs), resulting in the calcification of the tissue. Unfortunately, human VICs are not readily available to study CAVD pathogenesis and the implicated mechanisms in vitro; however, adipose-derived stromal/stem cells (ASCs), carrying the patient's specific genomic features, have emerged as a promising cell source to model cardiovascular diseases due to their multipotent nature, availability, and patient-specific characteristics...
February 14, 2024: International Journal of Molecular Sciences