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Autism pregnancy

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https://www.readbyqxmd.com/read/28448694/the-joint-effect-of-air-pollution-exposure-and-copy-number-variation-on-risk-for-autism
#1
Dokyoon Kim, Heather Volk, Santhosh Girirajan, Sarah Pendergrass, Molly A Hall, Shefali S Verma, Rebecca J Schmidt, Robin L Hansen, Debashis Ghosh, Yunin Ludena-Rodriguez, Kyoungmi Kim, Marylyn D Ritchie, Irva Hertz-Picciotto, Scott B Selleck
Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation, exposure to air pollutants, and the interaction between the two on autism risk, were evaluated in the population-based case-control Childhood Autism Risks from Genetics and Environment (CHARGE) Study. For the current investigation, we included only those CHARGE children (a) who met criteria for autism or typical development and (b) for whom our team had conducted both genetic evaluation of copy number burden and determination of environmental air pollution exposures based on mapping addresses from the pregnancy and early childhood...
April 27, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28448061/grand-maternal-smoking-in-pregnancy-and-grandchild-s-autistic-traits-and-diagnosed-autism
#2
Jean Golding, Genette Ellis, Steven Gregory, Karen Birmingham, Yasmin Iles-Caven, Dheeraj Rai, Marcus Pembrey
Although there is considerable research into the genetic background of autism spectrum disorders, environmental factors are likely to contribute to the variation in prevalence over time. Rodent experiments indicate that environmental exposures can have effects on subsequent generations, and human studies indicate that parental prenatal exposures may play a part in developmental variation. Here we use the Avon Longitudinal Study of Parents and Children (ALSPAC) to test the hypothesis that if the mother or father (F1) had been exposed to their own mother's (F0) smoking during pregnancy, the offspring (F2) would be at increased risk of autism...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28437536/influenza-vaccination-in-the-first-trimester-of-pregnancy-and-risk-of-autism-spectrum-disorder
#3
Alberto Donzelli, Alessandro Schivalocchi, Alessandro Battaggia
No abstract text is available yet for this article.
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28437533/influenza-vaccination-in-the-first-trimester-of-pregnancy-and-risk-of-autism-spectrum-disorder
#4
Brian S Hooker
No abstract text is available yet for this article.
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28437530/influenza-vaccination-in-the-first-trimester-of-pregnancy-and-risk-of-autism-spectrum-disorder-reply
#5
Ousseny Zerbo, Nicola P Klein, Lisa A Croen
No abstract text is available yet for this article.
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28424947/neurodevelopmental-effects-of-antiepileptic-drugs
#6
Marissa Kellogg, Kimford J Meador
Increasing evidence suggests that exposure to certain antiepileptic drugs (AEDs) during critical periods of development may induce transient or long-lasting neurodevelopmental deficits across cognitive, motor and behavioral domains. The developing nervous system may endure prolonged chronic exposure to AEDs during pregnancy (in utero) or during childhood, which can lead to neurodevelopmental defects such as congenital neural tube defects, lower IQ, language deficits, autism and ADHD. To date, valproate is the most widely recognized AED to significantly negatively affect neurodevelopment, and demonstrates greater adverse effects than any other AEDs that have been assessed...
April 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28424150/antidepressants-in-pregnancy-are-not-associated-with-autism-risk-new-study-finds
#7
Ingrid Torjesen
No abstract text is available yet for this article.
April 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28422339/prenatal-exposure-to-%C3%AE-2-adrenoreceptor-agonists-and-the-risk-of-autism-spectrum-disorders-in-offspring
#8
XiuJuan Su, Wei Yuan, JianPing Chen, MaoHua Miao, Jørn Olsen, Lars Henning Pedersen, Hong Liang, Jiong Li
PURPOSE: We aimed to examine the risk of autism spectrum disorders (ASDs) in the offspring who were exposed to maternal use of β2-adrenoreceptor agonist (β2AA) during pregnancy. METHODS: This is a population-based cohort study including all live singleton births in Denmark from 1 January 1997 to 31 December 2008. Children born to mothers who used β2AA during pregnancy were categorized as exposed, and all other children were included in the unexposed group. Cases of ASDs were identified from the Danish Psychiatric Central Register and the Danish Patient Register...
April 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28418571/risk-for-autism-spectrum-disorders-according-to-period-of-prenatal-antidepressant-exposure-a-systematic-review-and-meta-analysis
#9
Antonia Mezzacappa, Pierre-Alexandre Lasica, Francesco Gianfagna, Odile Cazas, Patrick Hardy, Bruno Falissard, Anne-Laure Sutter-Dallay, Florence Gressier
Importance: Several studies have examined the links between prenatal exposure to antidepressants and autism spectrum disorders (ASDs) in children, with inconsistent results, especially regarding the impact of the trimester of exposure. Objective: To perform a systematic review of the literature and a meta-analysis of published studies to assess the association between ASDs and fetal exposure to antidepressants during pregnancy for each trimester of pregnancy and preconception...
April 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28418480/association-between-serotonergic-antidepressant-use-during-pregnancy-and-autism-spectrum-disorder-in-children
#10
Hilary K Brown, Joel G Ray, Andrew S Wilton, Yona Lunsky, Tara Gomes, Simone N Vigod
Importance: Previous observations of a higher risk of child autism spectrum disorder with serotonergic antidepressant exposure during pregnancy may have been confounded. Objective: To evaluate the association between serotonergic antidepressant exposure during pregnancy and child autism spectrum disorder. Design, Setting, and Participants: Retrospective cohort study. Health administrative data sets were used to study children born to mothers who were receiving public prescription drug coverage during pregnancy in Ontario, Canada, from 2002-2010, reflecting 4...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28418479/associations-of-maternal-antidepressant-use-during-the-first-trimester-of-pregnancy-with-preterm-birth-small-for-gestational-age-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-in-offspring
#11
Ayesha C Sujan, Martin E Rickert, A Sara Öberg, Patrick D Quinn, Sonia Hernández-Díaz, Catarina Almqvist, Paul Lichtenstein, Henrik Larsson, Brian M D'Onofrio
Importance: Prenatal antidepressant exposure has been associated with adverse outcomes. Previous studies, however, may not have adequately accounted for confounding. Objective: To evaluate alternative hypotheses for associations between first-trimester antidepressant exposure and birth and neurodevelopmental problems. Design, Setting, and Participants: This retrospective cohort study included Swedish offspring born between 1996 and 2012 and followed up through 2013 or censored by death or emigration...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28418464/disentangling-maternal-depression-and-antidepressant-use-during-pregnancy-as-risks-for-autism-in-children
#12
EDITORIAL
Tim F Oberlander, Lonnie Zwaigenbaum
No abstract text is available yet for this article.
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28415925/the-role-of-oxidative-stress-inflammation-and-acetaminophen-exposure-from-birth-to-early-childhood-in-the-induction-of-autism
#13
William Parker, Chi Dang Hornik, Staci Bilbo, Zoie E Holzknecht, Lauren Gentry, Rasika Rao, Shu S Lin, Martha R Herbert, Cynthia D Nevison
The wide range of factors associated with the induction of autism is invariably linked with either inflammation or oxidative stress, and sometimes both. The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development. Thus, one explanation for the increased prevalence of autism is that increased exposure to acetaminophen, exacerbated by inflammation and oxidative stress, is neurotoxic in babies and small children...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28413441/prevalence-and-associated-factors-of-attention-deficit-hyperactivity-disorder-adhd-among-ugandan-children-a-cross-sectional-study
#14
Joan Wamulugwa, Angelina Kakooza, Sabrina Bakeera Kitaka, Joyce Nalugya, Mark Kaddumukasa, Shirley Moore, Martha Sajatovic, Elly Katabira
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder among the children. The burden of ADHD or its associated factors in Uganda are not known. The objective of this study was to determine the prevalence and the associated factors of ADHD among children attending the neurology and psychiatry clinics at Mulago National Referral Hospital. METHODS: Using the disruptive behavior scale (45 items), we investigated the presence of ADHD symptoms among children attending Mulago Hospital...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28409568/reply-to-magaret-and-wald-autism-link-to-herpes-simplex-virus-2-antibody-in-pregnancy-likely-to-be-spurious
#15
COMMENT
Milada Mahic, Siri Mjaaland, Ezra Susser, Michaeline Bresnahan, Xiaoyu Che, Bruce Levin, Mady Hornig, W Ian Lipkin
No abstract text is available yet for this article.
March 2017: MSphere
https://www.readbyqxmd.com/read/28405628/autism-link-to-herpes-simplex-virus-2-antibody-in-pregnancy-likely-to-be-spurious
#16
Amalia S Magaret, Anna Wald
No abstract text is available yet for this article.
March 2017: MSphere
https://www.readbyqxmd.com/read/28385052/perinatal-ssri-exposure-permanently-alters-cerebral-serotonin-receptor-mrna-in-mice-but-does-not-impact-adult-behaviors
#17
Lauritz R Meyer, Benjamin Dexter, Cecilia Lo, Elizabeth Kenkel, Takahito Hirai, Robert D Roghair, Sarah E Haskell
PURPOSE: Associations have been made between maternal selective serotonin reuptake inhibitor (SSRI) use during pregnancy and altered behavior in offspring, including an increased risk of autism. Given the important role serotonin plays in behavior, we hypothesized SSRI exposure in the perinatal period would alter central serotonin receptor expression and program adult behaviors in mice. METHODS: Female mice were injected with sertraline or saline throughout pregnancy...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28383115/clinical-clues-for-autoimmunity-and-neuroinflammation-in-patients-with-autistic-regression
#18
Ori Scott, Diya Shi, Diana Andriashek, Brenda Clark, Helly R Goez
AIM: Autistic regression is a unique variant within the autism spectrum disorders (ASDs), with recent reports raising the possibility of immune aetiology. This study explores clinical clues for an association between autistic regression and autoimmunity. METHOD: Single-centre charts of children diagnosed with ASD in 2014 were reviewed. We compared the rates of: (1) familial autoimmunity in first-degree and second-degree relatives; (2) febrile illness preceding initial parental concern, as a potential precipitant of immune activation; and (3) possible non-immune precipitants such as pregnancy and postnatal complications...
April 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28360521/rapamycin-modulated-brain-derived-neurotrophic-factor-and-b-cell-lymphoma-2-to-mitigate-autism-spectrum-disorder-in-rats
#19
Jie Zhang, Li-Ming Liu, Jin-Feng Ni
The number of children suffered from autism spectrum disorder (ASD) is increasing dramatically. However, the etiology of ASD is not well known. This study employed mammalian target of rapamycin inhibitor rapamycin to explore its effect on ASD and provided new therapeutic strategies for ASD. ASD rat model was constructed and valproic acid (VPA) was injected intraperitoneally into rats on pregnancy day 12.5. Offspring from VPA group were divided into ASD group and ASD + rapamycin (ASD + RAPA) group. Compared with normal group, the frequency and duration of social behavior and straight times of ASD group were shortened, but the grooming times were extended...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28359263/parental-exposures-to-occupational-asthmagens-and-risk-of-autism-spectrum-disorder-in-a-danish-population-based-case-control-study
#20
Alison B Singer, Igor Burstyn, Malene Thygesen, Preben Bo Mortensen, M Daniele Fallin, Diana E Schendel
BACKGROUND: Environmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD. We evaluated the association between parental workplace exposures to risk factors for asthma ("asthmagens") and ASD. METHODS: We conducted a population-based case-control study in the Danish population using register linkage. Our study population consisted of 11,869 ASD cases and 48,046 controls born from 1993 through 2007...
March 31, 2017: Environmental Health: a Global Access Science Source
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