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Cytokine dynamics

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https://www.readbyqxmd.com/read/28917326/serum-levels-of-cytokines-in-water-buffaloes-experimentally-infected-with-fasciola-gigantica
#1
Fu-Kai Zhang, Ai-Jiang Guo, Jun-Ling Hou, Miao-Miao Sun, Zhao-An Sheng, Xiao-Xuan Zhang, Wei-Yi Huang, Hany M Elsheikha, Xing-Quan Zhu
Fasciola gigantica infection in water buffaloes causes significant economic losses especially in developing countries. Although modulation of the host immune response by cytokine neutralization or vaccination is a promising approach to control infection with this parasite, our understanding of cytokine's dynamic during F. gigantica infection is limited. To address this, we quantified the levels of serum cytokines produced in water buffaloes following experimental infection with F. gigantica. Five buffaloes were infected via oral gavage with 500 viable F...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28913572/establishment-of-s100a8-transgenic-rats-to-understand-innate-property-of-s100a8-and-its-immunological-role
#2
Kohki Okada, Hiroshi Itoh, Yasuhiko Kamikubo, Souichi Adachi, Masaki Ikemoto
The innate properties of S100A8 as a regulator in acute inflammation have not yet been elucidated in detail. Our aims are to newly establish S100A8 transgenic rats (Tg-S100A8) and to elucidate the immunological functions of S100A8. Following the treatment with 5% dextran sulfate sodium for 1 week, the body weight in Tg-S100A8 weakly decreased after the start; however, that in Japanese Wistar rats (WT) significantly decreased in the end. The serum level of CRP in Tg-S100A8 was significantly lower than that in WT, although the concentration of CRP apparently increased in both Tg-S100A8 and WT...
September 14, 2017: Inflammation
https://www.readbyqxmd.com/read/28912781/microrna-dynamic-regulators-of-macrophage-polarization-and-plasticity
#3
REVIEW
Jezrom Bokcaerin Self-Fordham, Afsar Raza Naqvi, Juhi Raju Uttamani, Varun Kulkarni, Salvador Nares
The ability of a healthy immune system to clear the plethora of antigens it encounters incessantly relies on the enormous plasticity displayed by the comprising cell types. Macrophages (MΦs) are crucial member of the mononuclear phagocyte system (MPS) that constantly patrol the peripheral tissues and are actively recruited to the sites of injury and infection. In tissues, infiltrating monocytes replenish MΦ. Under the guidance of the local micro-milieu, MΦ can be activated to acquire specialized functional phenotypes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28904202/discrete-dynamical-modeling-of-influenza-infection-suggests-age-dependent-differences-in-immunity
#4
Ericka Keef, Li Ang Zhang, David Swigon, Alisa Urbano, G Bard Ermentrout, Michael Matuszewski, Franklin R Toapanta, Ted M Ross, Robert S Parker, Gilles Clermont
Immunosenescence, an age-related decline in immune function, is a major contributor to morbidity and mortality in the elderly. Older hosts exhibit delayed onset of immunity and prolonged inflammation after an infection, leading to excess damage and greater likelihood of death. Our study applies a rule-based model to infer which components of immune response are most changed in an aged host. Two groups of BALB/c mice (age 12-16 wks and 72-76 wks) were infected at 2 inocula: a survivable 50 PFU dose and a lethal 500 PFU dose...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28900770/how-regularities-of-mortality-statistics-explain-why-we-age-despite-having-potentially-ageless-somatic-stem-cells
#5
Alexander V Khalyavkin, Vyacheslav N Krut'ko
Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, rising of pro-inflammatory cytokines, etc. This results in an increase in the proportion of cells in growth arrest, reduction of the rate of information processing, metabolic rate decrease, and decrease in rates of other processes characterizing dynamic aspects of the organism's interaction with its environment...
September 12, 2017: Biogerontology
https://www.readbyqxmd.com/read/28900100/oscillations-of-ultra-weak-photon-emission-from-cancer-and-non-cancer-cells-stressed-by-culture-medium-change-and-tnf-%C3%AE
#6
Pierre Madl, Thomas Verwanger, Mark Geppert, Felix Scholkmann
Cells spontaneously emit photons in the UV to visible/near-infrared range (ultra-weak photon emission, UPE). Perturbations of the cells' state cause changes in UPE (evoked UPE). The aim of the present study was to analyze the evoked UPE dynamics of cells caused by two types of cell perturbations (stressors): (i) a cell culture medium change, and (ii) application of the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α). Four types of human cell lines were used (squamous cell carcinoma cells, A431; adenocarcinomic alveolar basal epithelial cells, A549; p53-deficient keratinocytes, HaCaT, and cervical cancer cells, HeLa)...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898706/profiles-of-pro-inflammatory-cytokines-in-allogenic-stem-cell-transplantation-with-post-transplant-cyclophosphamide
#7
O V Pirogova, I S Moiseev, E A Surkova, S V Lapin, S N Bondarenko, A D Kulagin, B V Afanasyev
Large number of studies was published about predictive value of cytokines for graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. Recently, there has been a growing interest in GVHD prophylaxis with post-transplant cyclophosphamide (PTCy). Clinical data on the dynamics of proinflammatory cytokines with this prophylaxis is lacking. In this study, we have measured the levels of IL-17, IL-6, IL-8, IFN-γ and TNF-α in plasma on days -7, 0, +7, +14 and after engraftment in 20 patients with acute GVHD and 40 matched control patients with PTCy-based prophylaxis...
September 9, 2017: Cytokine
https://www.readbyqxmd.com/read/28894448/sirtuin-2-deficiency-increases-bacterial-phagocytosis-by-macrophages-and-protects-from-chronic-staphylococcal-infection
#8
Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mainly in the cytoplasm and regulates cytoskeleton dynamics, cell cycle, and metabolic pathways. As such, SIRT2 has been implicated in the pathogenesis of neurodegenerative, metabolic, oncologic, and chronic inflammatory disorders. This motivated the development of SIRT2-directed therapies for clinical purposes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28894444/modeling-kick-kill-strategies-toward-hiv-cure
#9
REVIEW
Esteban A Hernandez-Vargas
Although combinatorial antiretroviral therapy (cART) potently suppresses the virus, a sterile or functional cure still remains one of the greatest therapeutic challenges worldwide. Reservoirs are infected cells that can maintain HIV persistence for several years in patients with optimal cART, which is a leading obstacle to eradicate the virus. Despite the significant progress that has been made in our understanding of the diversity of cells that promote HIV persistence, many aspects that are critical to the development of effective therapeutic approaches able to purge the latent CD4+ T cell reservoir are poorly understood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28894116/characterization-of-tonsillar-il10-secreting-b-cells-and-their-role-in-the-pathophysiology-of-tonsillar-hypertrophy
#10
Lindybeth Sarmiento Varon, Javier De Rosa, Andrés Machicote, Luis Ariel Billordo, Plácida Baz, Pablo Mariano Fernández, Isabel Kaimen Maciel, Andrés Blanco, Eloísa I Arana
The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28883891/the-in-vitro-and-ex-vivo-effect-of-auranta-3001-in-preventing-cryptosporidium-hominis-and-cryptosporidium-parvum-infection
#11
Alexandros Ch Stratakos, Filip Sima, Patrick Ward, Mark Linton, Carmel Kelly, Laurette Pinkerton, Lavinia Stef, Ioan Pet, Tiberiu Iancu, Gratiela Pircalabioru, Nicolae Corcionivoschi
BACKGROUND: Cryptosporidium is a major cause of diarrhea worldwide in both humans and farm animals with no completely effective treatment available at present. In this study, we assessed the inhibitory effect of different concentrations of Auranta 3001 (0.1, 0.5 and 1%), a novel natural feed supplement, on C. hominis and C. parvum invasion of human ileocecal adenocarcinoma (HCT-8), bovine primary cells and C. parvum invasion of HCT-8, bovine primary cells and bovine intestinal biopsies...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28881843/dynamic-changes-in-serum-cytokine-levels-and-their-clinical-significance-in-predicting-acute-gvhd
#12
Chunyan Zhang, Wenrong Huang, Pengjun Zhang, Qingyi Zhang, Guanghong Guo, Feng Gu, Hua Yang, Yurong Wang, Xueliang Huang, Qian Jia, Yaping Tian
To explore the clinical significance of cytokines and biochemical tests in acute graft-versus-host disease (aGVHD), we detected the concentrations of 8 cytokines and 19 conventional biochemical markers in the sera of aGVHD and non-GVHD patients throughout the process of allogeneic hematopoietic stem cell transplantation and the onset of aGVHD. Predictive models were then established using the 27 indices, and models were verified by a prospective trial. The 27 indices showed significant differences between aGVHD patients and non-GVHD control subjects (two-tailed p<0...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878689/a20-tnfaip3-discriminates-tumor-necrosis-factor-tnf-induced-nf-%C3%AE%C2%BAb-from-jnk-pathway-activation-in-hepatocytes
#13
Federico Pinna, Michaela Bissinger, Katharina Beuke, Nicolas Huber, Thomas Longerich, Ursula Kummer, Peter Schirmacher, Sven Sahle, Kai Breuhahn
In the liver tumor necrosis factor (TNF)-induced signaling critically regulates the immune response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes via activation of the NF-κB and JNK pathways. Especially, the induction of negative feedback regulators, such as IκBα and A20 is responsible for the dynamic and time-restricted response of these important pathways. However, the precise mechanisms responsible for different TNF-induced phenotypes under physiological stimulation conditions are not completely understood so far...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28877030/radiation-mitigating-properties-of-intranasally-administered-kl4-surfactant-in-a-murine-model-of-radiation-induced-lung-damage
#14
Melpo Christofidou-Solomidou, Ralph A Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, Robert Segal
The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced lung disease can manifest with an acute radiation pneumonitis and/or delayed effects leading to pulmonary fibrosis. As prior warning of radiation exposure is unlikely, medical countermeasures (MCMs) to mitigate radiation-induced lung disease that can be given in mass-casualty situations many hours or days postirradiation are needed to prevent both early and late lung damage...
September 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28875577/biocompatibility-assessment-of-cyclic-olefin-copolymers-impact-of-two-additives-on-cytotoxicity-oxidative-stress-inflammatory-reactions-and-hemocompatibility
#15
Mélisande Bernard, Emile Jubeli, Joudi Bakar, Lionel Tortolano, Johanna Saunier, Najet Yagoubi
This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films...
September 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28870864/counter-regulation-of-ecrg4-gene-expression-by-hypermethylation-dependent-inhibition-and-the-sp1-transcription-factor-dependent-stimulation-of-the-c2orf40-promoter
#16
Xitong Dang, Xiaorong Zeng, Raul Coimbra, Brian P Eliceiri, Andrew Baird
The human cytokine precursor ECRG4 has been associated with multiple physiological, developmental and pathophysiological processes involving cell proliferation, cell migration, innate immunity, inflammation, cancer progression and metastases. Although down-regulation of ECRG4 gene expression has been largely attributed to hypermethylation of CpG islands in the 5'untranslated region of the ECRG4 promoter, the mechanisms that underlie the dynamics of its regulation have never been systematically described. Here we show that the ECRG4 gene is widely expressed in human tissues and report that its core promoter lies between the -780 to +420 base pairs relative to the ATG start codon of the ECRG4 open reading frame...
September 1, 2017: Gene
https://www.readbyqxmd.com/read/28866066/the-quantitative-and-functional-changes-of-post-operative-pb-immune-cell-subsets-relate-to-sah-patients-prognosis-a-preliminary-study
#17
Yugang Jiang, Yu Zhou, Yong Peng, Mingming Zhang
OBJECTIVE: It has been suggested that the preoperative (PRE) and postoperative (POST) immune system alteration triggered by aneurysmal subarachnoid hemorrhage (SAH) and surgical treatment itself may affect patients' prognosis and contribute to postoperative complications. The mechanisms maybe attributed to immune-suppression triggered infection or immune-overreaction triggered aseptic inflammation. In this study, we investigated the dynamic changes in peripheral immune cell subsets as well as the alterations of inflammatory cytokines in aneurysmal SAH patients who received craniotomy and clipping surgery...
August 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28865757/a-cell-impedance-based-real-time-in-vitro-assay-to-assess-the-toxicity-of-amphotericin-b-formulations
#18
Jean Menotti, Alexandre Alanio, Aude Sturny-Leclère, Sandrine Vitry, Félix Sauvage, Gillian Barratt, Stéphane Bretagne
Aerosolized liposomal amphotericin B (L-AmB) has been investigated as prophylaxis against invasive aspergillosis. However, the clinical results are controversial and some trials suggest that toxicity could be a limitation for wider use. Our aim was to assess the dynamics of cell toxicity induced in a human alveolar epithelial cell line (A549) after exposure to L-AmB (50 to 400μg/ml) or amphotericin B deoxycholate (D-AmB; 50 to 200μg/ml) by monitoring real-time A549 cell viability using an impedance-based technology...
September 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28855862/novel-influences-of-il-10-on-cns-inflammation-revealed-by-integrated-analyses-of-cytokine-networks-and-microglial-morphology
#19
Warren D Anderson, Andrew D Greenhalgh, Aditya Takwale, Samuel David, Rajanikanth Vadigepalli
Coordinated interactions between cytokine signaling and morphological dynamics of microglial cells regulate neuroinflammation in CNS injury and disease. We found that pro-inflammatory cytokine gene expression in vivo showed a pronounced recovery following systemic LPS. We performed a novel multivariate analysis of microglial morphology and identified changes in specific morphological properties of microglia that matched the expression dynamics of pro-inflammatory cytokine TNFα. The adaptive recovery kinetics of TNFα expression and microglial soma size showed comparable profiles and dependence on anti-inflammatory cytokine IL-10 expression...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28855374/differential-mast-cell-outcomes-are-sensitive-to-fc%C3%AE%C2%B5ri-syk-binding-kinetics
#20
Samantha L Schwartz, Cédric Cleyrat, Mark J Olah, Peter K Relich, Genevieve K Phillips, William S Hlavacek, Keith A Lidke, Bridget S Wilson, Diane S Lidke
Crosslinking of IgE-bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation motifs. Using single molecule imaging in live cells, we directly visualized and quantified the binding of individual mNeonGreen-tagged Syk molecules as they associated with the plasma membrane after FcεRI activation. We found that Syk colocalizes transiently to FcεRI and that Syk-FcεRI binding dynamics are independent of receptor aggregate size...
August 30, 2017: Molecular Biology of the Cell
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