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Cytokine dynamics

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https://www.readbyqxmd.com/read/29140571/is-overactive-bladder-microvasculature-disease-a-component-of-systemic-atheroscleorosis
#1
Ahmet Ozgur Yeniel, Ahmet Mete Ergenoglu, Reci Meseri, Erkan Kismali, Anıl Ari, Gulgun Kavukcu, Hikmet H Aydin, Handan Ak, Sevcan Atay, Ismail Mete Itil
AIMS: To evaluate the relationship between overactive bladder (OAB) and systemic atherosclerosis in a cohort of women. METHODS: In this case-control study, we assessed atherosclerosis indicators, such as Framingham risk scores and carotid and femoral artery intima-media thickness, and evaluated possible bladder wall responses to atherosclerosis using endovaginal color Doppler ultrasound and the detection of urinary cytokines in women with OAB and in controls. Quantitative assessment of blood perfusion at the bladder neck was performed using a method that allows for the dynamic monitoring of flow in a predefined region of interest at every point of the cardiac cycle...
November 15, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29135738/efficacy-of-rebamipide-instillation-for-contact-lens-discomfort-with-dry-eye
#2
Tsutomu Igarashi, Maika Kobayashi, Chiemi Yaguchi, Chiaki Fujimoto, Hisaharu Suzuki, Hiroshi Takahashi
OBJECTIVE: To examine the effects of rebamipide ophthalmic solution on the symptoms, signs, and cytokine concentrations in tear fluid among soft contact lens (SCL) wearers with Dry eye disease (DED). METHODS: From November 2015 to June 2017, this open-label, single-arm study examined 40 eyes of 20 SCL wearers with DED who had been using daily disposable SCLs for >3 months (mean age, 30.0±8.33 years; range, 20-47 years). Signs, symptoms, and cytokine concentrations were assessed before and 4 weeks after starting 2% rebamipide ophthalmic solution 4 times/day...
November 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29131464/interferon-regulatory-factor-4-5-signaling-impacts-on-microglial-activation-after-ischemic-stroke-in-mice
#3
Abdullah Al Mamun, Anjali Chauhan, Haifu Yu, Yan Xu, Romana Sharmeen, Fudong Liu
Microglial activation is a key element in initiating and perpetuating inflammatory responses to stroke. Interferon regulatory factor 5 (IRF5) and IRF4 signaling have been found critical in mediating macrophage pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes respectively in peripheral inflammation. We hypothesize that the IRF5/4 regulatory axis also mediates microglial activation after stroke. C57BL6 mice of 8-12 weeks were subject to a 90-minute middle cerebral artery occlusion and the brains evaluated at 24h, 3d, 10d and 30d after reperfusion...
November 13, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29128333/nf-%C3%AE%C2%BAb-dynamics-discriminate-between-tnf-doses-in-single-cells
#4
Qiuhong Zhang, Sanjana Gupta, David L Schipper, Gabriel J Kowalczyk, Allison E Mancini, James R Faeder, Robin E C Lee
Although cytokine-dependent dynamics of nuclear factor κB (NF-κB) are known to encode information that regulates cell fate decisions, it is unclear whether single-cell responses are switch-like or encode more information about cytokine dose. Here, we measure the dynamic subcellular localization of NF-κB in response to a range of tumor necrosis factor (TNF) stimulation conditions to determine the prevailing mechanism of single-cell dose discrimination. Using an information theory formalism that accounts for signaling dynamics and non-responsive cell subpopulations, we find that the information transmission capacity of single cells exceeds that predicted from a switch-like response...
November 7, 2017: Cell Systems
https://www.readbyqxmd.com/read/29127842/budesonide-facilitates-weaning-from-mechanical-ventilation-in-difficult-to-wean-very-severe-copd-patients-association-with-inflammatory-mediators-and-cells
#5
Seyed Mohammadreza Hashemian, Esmaeil Mortaz, Hamidreza Jamaati, Leila Bagheri, Seyed Amir Mohajerani, Johan Garssen, Masoud Movassaghi, Peter J Barnes, Nicholas S Hill, Ian M Adcock
INTRODUCTION: Mechanical ventilatory support is life-saving therapy for patients with respiratory failure in intensive care units (ICU) but is linked to ventilator-associated pneumonia and other nosocomial infections. Interventions that improve the efficiency of weaning from mechanical ventilation may improve patient outcomes. OBJECTIVE: To determine whether inhaled budesonide decreases time-to-weaning in COPD stage 4 difficult-to-wean patients and reduces the release of pro-inflammatory cytokines in ICU patients...
October 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29123649/the%C3%A2-%C3%AE-c%C3%A2-family-of-cytokines-fine-tuning-signals-from-il-2-and-il-21-in-the-regulation-of-the-immune-response
#6
REVIEW
Rosanne Spolski, Daniel Gromer, Warren J Leonard
Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ c, which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as mediating effector function. Here, we provide an overview of the main actions of members of this cytokine family but then primarily focus on IL-2 and IL-21, discussing their dynamic interplay and contributions to a fine-tuned immune response...
2017: F1000Research
https://www.readbyqxmd.com/read/29123511/a-high-grain-diet-dynamically-shifted-the-composition-of-mucosa-associated-microbiota-and-induced-mucosal-injuries-in-the-colon-of-sheep
#7
Yue Wang, Lei Xu, Junhua Liu, Weiyun Zhu, Shengyong Mao
This study investigated the dynamic shifts in mucosa-associated microbiota composition and mucosal morphology in the colon of sheep fed a high grain (HG) diet. A total of 20 male sheep were randomly assigned to four groups (n = 5 for each). The sheep in first group received hay diet. The animals in other 3 groups were fed an HG diet for 7 (HG7), 14 (HG14), or 28 (HG28) days, respectively. Colonic digesta samples were collected to determine the pH and the concentrations of volatile fatty acid (VFA) and lactate...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29117112/in-vivo-imaging-of-microglial-calcium-signaling-in-brain-inflammation-and-injury
#8
REVIEW
Petr Tvrdik, M Yashar S Kalani
Microglia, the innate immune sentinels of the central nervous system, are the most dynamic cells in the brain parenchyma. They are the first responders to insult and mediate neuroinflammation. Following cellular damage, microglia extend their processes towards the lesion, modify their morphology, release cytokines and other mediators, and eventually migrate towards the damaged area and remove cellular debris by phagocytosis. Intracellular Ca(2+) signaling plays important roles in many of these functions. However, Ca(2+) in microglia has not been systematically studied in vivo...
November 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29115376/ccdc134-serves-a-crucial-role-in-embryonic-development
#9
Biaoyi Yu, Tianzhuo Zhang, Peng Xia, Xiaoting Gong, Xiaoyan Qiu, Jing Huang
Coiled-coil domain containing 134 (CCDC134), a characterized secreted protein, may serve as an immune cytokine and illustrates its potent antitumor effects by augmenting CD8+ T-cell-mediated immunity. Additionally, CCDC134 may also act as a novel regulator of human alteration/deficiency in activation 2a, and be involved in the p300-CBP-associated factor complex and affect its acetyltransferase activity. To clarify the biological and pathological function of CCDC134, the present study generated a viable and fertile Ccdc134fl/fl mouse strain that allowed temporal and spatial control of gene ablation...
October 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29112971/effects-of-positive-end-expiratory-pressure-and-recruitment-maneuvers-in-a-ventilator-induced-injury-mouse-model
#10
Laura A Cagle, Lisa M Franzi, Angela L Linderholm, Jerold A Last, Jason Y Adams, Richart W Harper, Nicholas J Kenyon
BACKGROUND: Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury...
2017: PloS One
https://www.readbyqxmd.com/read/29112826/immunohistochemical-analysis-on-cortex-to-cortex-healing-after-mandibular-vertical-ramus-osteotomy-a-preliminary-study
#11
Hwi-Dong Jung, Sang Yoon Kim, Han-Sung Jung, Hyung-Sik Park, Young-Soo Jung
PURPOSE: The present study analyzed the expression of specific cytokines in the transforming growth factor (TGF)-β superfamily postoperatively after mandibular vertical ramus osteotomy (VRO). MATERIALS AND METHODS: Four beagle dogs were enrolled and euthanized at 1, 2, 4, and 8 weeks postoperatively for immunohistochemical analysis using 6 specific antibodies (bone morphogenetic protein [BMP]-2/4, BMP-7, TGF-β2, TGF-β3, matrix metalloproteinase-3, and vascular endothelial growth factor [VEGF])...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29109724/actors-and-factors-in-the-resolution-of-intestinal-inflammation-lipid-mediators-as-a-new-approach-to-therapy-in-inflammatory-bowel-diseases
#12
REVIEW
Federica Ungaro, Federica Rubbino, Silvio Danese, Silvia D'Alessio
In the last few decades, the pathogenesis of inflammatory bowel disease (IBD) in genetically predisposed subjects susceptible to specific environmental factors has been attributed to disturbance of both the immune and non-immune system and/or to the imbalanced interactions with microbes. However, increasing evidences support the idea that defects in pro-resolving pathways might strongly contribute to IBD onset. The resolution of inflammation is now recognized as a dynamic event coordinated by specialized pro-resolving lipid mediators (LMs), which dampen inflammation-sustaining events, such as angiogenesis, release of pro-inflammatory cytokines, clearance of apoptotic cells, and microorganisms...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29106986/intraperitoneal-administration-of-a-novel-chimeric-immunogen-rop-elicits-ifn-%C3%AE-and-il-12p70-protective-immune-response-in-balb-c-mice-against-virulent-brucella
#13
Ganesh Tadepalli, Balakrishna Konduru, Harishchandra Sripathy Murali, Harsh Vardhan Batra
Recombinant engineering of immunologically active chimeric protein consisting of Omp19 and P39 domains of B. abortus (rOP), was purified under denaturing conditions upon expression in E. coli BL21 (DE3) and refolded to dynamic form. The immuno-protective efficacy of rOP was evaluated by challenging the BALB/c mice intraperitoneally (I.P) with the infective species of Brucella in the absence or presence of adjuvants, such as Aluminum hydroxide gel (Al), or Freund's Complete Adjuvant (FCA)/Incomplete Freund's Adjuvant (IFA)...
October 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29106931/interplay-between-keratinocytes-and-myeloid-cells-drives-dengue-virus-spread-in-human-skin
#14
Parichat Duangkhae, Geza Erdos, Kate D Ryman, Simon C Watkins, Louis D Falo, Ernesto T A Marques, Simon M Barratt-Boyes
The skin is the site of dengue virus (DENV) transmission following the bite of an infected mosquito, but the contribution of individual cell types within skin to infection is unknown. We studied the dynamics of DENV infection in human skin explants using quantitative in situ imaging. DENV replicated primarily in the epidermis and induced a transient interferon-α response. DENV infected a wide range of cells, including Langerhans cells, macrophages, dermal dendritic cells (DC), mast cells, fibroblasts and lymphatic endothelium, but keratinocytes were the earliest targets of infection and made up 60% of infected cells over time...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29104502/mesenchymal-stem-cell-dependent-modulation-of-liver-diseases
#15
REVIEW
Marina Gazdic, Aleksandar Arsenijevic, Bojana Simovic Markovic, Ana Volarevic, Ivanka Dimova, Valentin Djonov, Nebojsa Arsenijevic, Miodrag Stojkovic, Vladislav Volarevic
Acute liver failure and cirrhosis display sequential and overlapping severe pathogenic processes that include inflammation, hepatocyte necrosis, and fibrosis, carrying a high mortality rate. Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells with immunonodulatory characteristics. MSCs are considered to act through multiple mechanisms to coordinate a dynamic, integrated response to liver inflammation and fibrosis, which prevents the progressive distortion of hepatic architecture. Accordingly, MSCs as well as their products have been investigated as a novel therapeutic approach for the treatment of inflammatory and fibrotic liver diseases...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29102675/rna-seq-revealed-atf3-regulated-inflammation-induced-by-silica
#16
Judy Y W Chan, Joseph C C Tsui, Patrick T W Law, Winnie K W So, Doris Y P Leung, Michael M K Sham, Stephen K W Tsui, Carmen W H Chan
BACKGROUND: Millions of workers are exposed to dust containing silica. Chronic and over-exposure to silica will lead to silicosis, which is an irreversible and sometimes fatal lung disease. The disordered physiological processes of silicosis consist of accumulation of silica particles in the alveoli of the lung. Then, the ingestion of the silica particles by macrophages was followed by an inflammatory response. Up till now, the chest radiographs remain the key tool in diagnosing and assessing the extent of silicosis...
November 2, 2017: Toxicology
https://www.readbyqxmd.com/read/29101162/ex-vivo-profiling-of-pd-1-blockade-using-organotypic-tumor-spheroids
#17
Russell W Jenkins, Amir R Aref, Patrick H Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A Kaplan, Andrew Portell, Prafulla C Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C Thai, Marc R Hammond, Raven Vlahos, Eric S Wang, Hua Zhang, Shuai Li, Glenn J Hanna, Wei Huang, Mai P Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M Cleary, Brian C Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U Barbie, Vivek Sivathanu, Joshua Wong, William G Richards, Raphael Bueno, Charles H Yoon, Juan Miret, Meenhard Herlyn, Levi A Garraway, Eliezer M Van Allen, Gordon J Freeman, Paul T Kirschmeier, Jochen H Lorch, Patrick A Ott, F Stephen Hodi, Keith T Flaherty, Roger D Kamm, Genevieve M Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A Barbie
Ex vivo systems that incorporate features of the tumor microenvironment (TME) and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology and the development of effective combination therapies. Here, we demonstrate the ability to interrogate ex vivo response to ICB using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS). MDOTS/PDOTS isolated from mouse and human tumors retain autologous lymphoid and myeloid cell populations, and respond to ICB in short-term 3-dimensional microfluidic culture...
November 3, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29100004/autologous-chondrocyte-implantation-in-osteoarthritic-surroundings-tnf%C3%AE-and-its-inhibition-by-adalimumab-in-a-knee-specific-bioreactor
#18
Robert Ossendorff, Sibylle Grad, Martin J Stoddart, Mauro Alini, Hagen Schmal, Norbert Südkamp, Gian M Salzmann
BACKGROUND: Autologous chondrocyte implantation (ACI) fails in up to 20% of cases. Advanced intra-articular degeneration paired with an inflammatory environment may be closely related to implantation failure. Certain cytokines have been identified to play a major role during early osteoarthritis. PURPOSE: To investigate the effects of tumor necrosis factor α (TNFα) and its potential inhibition by adalimumab on cartilage regeneration in an in vitro model of ACI...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29097227/the-role-of-the-nlrp3-inflammasome-in-regulation-of-antiviral-responses-to-influenza-a-virus-infection
#19
REVIEW
Soroush T Sarvestani, Julie L McAuley
The innate immune system provides the host with both a dynamic barrier to prevent infection and a means to which rapid anti-microbial responses can be mounted. The inflammasome pathway is a critical host early response mechanism that enables detection of pathogens and initiates production of inflammatory cytokines, inducing recruitment of effector cells to the site of infection. The complete mechanism of inflammasome activation requires two signals: an initial priming step upon detection of pathogen, followed by activation of intracellular pattern recognition receptors critical to the formation of the inflammasome complex...
October 31, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29096891/association-of-cytokines-and-chemokines-in-pathogenesis-of-breast-cancer
#20
Jeronay King, Hina Mir, Shailesh Singh
Breast cancer touches women's life worldwide. Expected outcome is not achieved due to molecular heterogeneity and complex biology despite substantial advancement in diagnosis, prevention and treatment of breast cancer. Patients with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (Her2) positive tumors receive hormone ablation and Her2 directed therapy. While patients diagnosed with triple-negative breast cancer receive chemotherapy in both the early and advanced stages...
2017: Progress in Molecular Biology and Translational Science
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