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https://www.readbyqxmd.com/read/28937540/herpes-simplex-virus-esophagitis-in-immunocompetent-children-a-harbinger-of-eosinophilic-esophagitis
#1
Julia Fritz, Diana Lerner, Mariko Suchi
Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed sixteen cases of HSV esophagitis diagnosed from January, 1982 to March, 2016. Five patients were immunosuppressed, 11 were immunocompetent and included in the study. Three (27%) had no other significant medical history. Five patients (45%) had repeat biopsies following their HSV infection which showed eosinophilic infiltrate consistent with current diagnostic criteria of eosinophilic esophagitis (EoE), one of whom had known EoE...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937369/study-of-association-of-epstein-barr-virus-in-lymphomas-by-epstein-barr-virus-encoded-rna-in-situ-hybridization-an-indian-perspective-from-a-tertiary-care-cancer-institute
#2
Roshani Gala, Jatin S Gandhi, Gurudutt Gupta, Shrruti K Grover, Anila Sharma, Sunil Pasricha, Anurag Mehta
BACKGROUND: The Epstein-Barr virus (EBV), also called human herpesvirus 4, is a virus of the herpes family. The EBV-associated lymphomas include Burkitt lymphoma, classic Hodgkin lymphoma (HL), lymphomas arising in immunocompromised individuals, peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, extranodal nasal-type natural killer/T-cell lymphoma, and other rare histotypes. OBJECTIVE: The present study evaluated the role of EBV as an etiologic agent in various lymphomas and determined an Indian perspective in a tertiary care cancer center compared to that of Western literature...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936707/immunoglobulin-genotypes-and-cognitive-functions-in-schizophrenia
#3
Janardan P Pandey, Aryan M Namboodiri, Paul J Nietert, Reiji Yoshimura, Hikaru Hori
Exposure to neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus, has been reported to be associated with cognitive impairment in schizophrenia. These viruses have evolved highly sophisticated strategies for decreasing the efficacy of the host immune response and interfering with viral clearance. Particular immunoglobulin GM (γ marker) genotypes modulate these viral immunoevasion strategies, influence antibody responsiveness to viral proteins, and are also associated with susceptibility to schizophrenia, providing an excellent rationale for determining their possible involvement in the cognitive functions in this highly heritable neurodevelopmental disorder...
September 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28933221/neural-stem-cell-transplantation-is-associated-with-inhibition-of-apoptosis-bcl-xl-upregulation-and-recovery-of-neurological-function-in-a-rat-model-of-traumatic-brain-injury
#4
Ai-Lan Pang, Liu-Lin Xiong, Qing-Jie Xia, Fen Liu, You-Cui Wang, Fei Liu, Piao Zhang, Bu-Liang Meng, Sheng Tan, Ting-Hua Wang
Traumatic brain injury (TBI) is a common disease that usually causes severe neurological damage, and current treatment is far from satisfactory. The neuroprotective effects of neural stem cell (NSC) transplantation in the injured nervous system have largely been known, but the underlying mechanisms remain unclear, and their limited sources impede their clinical application. Here, we established a rat model of TBI by dropping a weight onto the cortical motor area of the brain and explored the effect of engrafted NSCs (passage 3, derived from the hippocampus of embryonic 12- to 14-d green fluorescent protein transgenic mice) on TBI rats...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932137/role-of-herpesviruses-in-chronic-periodontitis-and-their-association-with-clinical-parameters-and-in-increasing-severity-of-the-disease
#5
Mohammad Mukhit Abdul Gaffar Kazi, Renu Bharadwaj
OBJECTIVE: This study aims to assess the role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity. MATERIALS AND METHODS: This was a prospective case-control study. Ethical approval and prior consent were taken. A subgingival plaque sample was collected from a total of 300 patients and 300 controls and processed for DNA extraction and multiplex polymerase chain reaction for detection of herpesviruses...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28931680/molecular-evolution-of-herpes-simplex-virus-2-complete-genomes-comparison-between-primary-and-recurrent-infections
#6
Miguel A Minaya, Travis Jensen, Johannes Goll, Maria Korom, Sree H Datla, Robert B Belshe, Lynda A Morrison
Herpes simplex virus (HSV)-1 and -2 are large, double-stranded DNA viruses that cause lifelong persistent infections characterized by periods of quiescence and recurrent disease. How HSV evolves within an infected individual experiencing multiple episodes of reactivation over time is not known. We determined genome sequences of viruses isolated from two subjects in the Herpevac Trial for Women who experienced primary HSV-2 genital disease and compared them with sequences of viruses isolated from the subsequent fifth or sixth episode of recurrent disease in the same individuals...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28931225/persistent-herpesvirus-infections-and-telomere-attrition-over-3-years-in-the-whitehall-ii-cohort
#7
Jennifer B Dowd, Jos A Bosch, Andrew Steptoe, Bamini Jayabalasingham, Jue Lin, Robert Yolken, Allison E Aiello
The determinants of telomere attrition, a potential marker of cellular aging, are not well understood. Persistent herpesvirus infections including cytomegalovirus (CMV) infection may be particularly important for telomere dynamics via mechanisms such as inflammation, oxidative stress, and their impact on peripheral blood lymphocyte composition. This study examined the association of 4 human herpesviruses (CMV, herpes simplex virus type 1, human herpesvirus type 6, and Epstein-Barr virus) with change in leukocyte telomere length (LTL) over 3 years in 400 healthy individuals (aged 53-76 years) from the Whitehall II cohort...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28930847/guillain-barr%C3%A3-like-axonal-polyneuropathy-associated-with-toscana-virus-infection-a-case-report
#8
Eugenia Rota, Nicola Morelli, Paolo Immovilli, Paola De Mitri, Donata Guidetti
RATIONALE: Numerous cases of post-infectious Guillain-Barré syndrome (GBS) have been reported in the literature. Toscana virus (TOSV) is an arthropod-borne emerging pathogen in the Mediterranean area. PATIENT CONCERNS: A 40-year-old male patient was admitted to hospital for acute facial weakness, associated to numbness paraesthesias at lower and upper limbs. The neurological examination revealed facial diplegia and reduced tendon reflexes. The nerve conduction studies documented an acute motor and sensory axonal neuropathy (AMSAN); the lumbar puncture detected albuminocytologic dissociation...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929964/-investigation-of-bacterial-and-viral-etiology-in-community-acquired-central-nervous-system-infections-with-molecular-methods
#9
Hasip Kahraman, Alper Tünger, Şebnem Şenol, Hörü Gazi, Meltem Avcı, Bahar Örmen, Nesrin Türker, Sabri Atalay, Şükran Köse, Sercan Ulusoy, Meltem Işıkgöz Taşbakan, Oğuz Reşat Sipahi, Tansu Yamazhan, Zeynep Gülay, Sema Alp Çavuş, Hüsnü Pullukçu
In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-V1 ACE Detection kits herpes simplex virus-1 (HSV1), herpes simplex virus-2 (HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses))...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28928148/genome-wide-engineering-of-an-infectious-clone-of-herpes-simplex-virus-type-1-using-synthetic-genomics-assembly-methods
#10
Lauren M Oldfield, Peter Grzesik, Alexander A Voorhies, Nina Alperovich, Derek MacMath, Claudia D Najera, Diya Sabrina Chandra, Sanjana Prasad, Vladimir N Noskov, Michael G Montague, Robert M Friedman, Prashant J Desai, Sanjay Vashee
Here, we present a transformational approach to genome engineering of herpes simplex virus type 1 (HSV-1), which has a large DNA genome, using synthetic genomics tools. We believe this method will enable more rapid and complex modifications of HSV-1 and other large DNA viruses than previous technologies, facilitating many useful applications. Yeast transformation-associated recombination was used to clone 11 fragments comprising the HSV-1 strain KOS 152 kb genome. Using overlapping sequences between the adjacent pieces, we assembled the fragments into a complete virus genome in yeast, transferred it into an Escherichia coli host, and reconstituted infectious virus following transfection into mammalian cells...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28927283/proposed-anti-hsv-compounds-isolated-from-simira-species
#11
Jessica F Cavalcanti, Marcelo F de Araujo, Priscila B Gonçalves, Nelilma C Romeiro, Maria T Villela Romanos, Ivo J Curcino Vieira, Raimundo Braz-Filho, Mário G de Carvalho
Secondary metabolites isolated from Simira eleiezeriana and Simira glaziovii were evaluated against herpes simplex virus (HSV-1) and (HSV-2). The 50% effective concentrations values (EC50) were calculated from the dose-response curve and the selectivity index (SI) against the virus. The physicochemical data LogP, (PSA), (NRB), (HBA) and (HBD) were obtained using Marvin Sketch. Among the tested compounds, conipheraldeyde, harman and simirane A showed better results with EC50 6.39; 4.90; 4.61 µg/mL and SI 78...
September 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28927006/emerging-roles-of-heparanase-in-viral-pathogenesis
#12
REVIEW
Neel Thakkar, Tejabhiram Yadavalli, Dinesh Jaishankar, Deepak Shukla
Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide that binds growth factors, cytokines, and chemokines, and thereby controls several important physiological functions. Ironically, many human pathogens including viruses interact with it for adherence to host cells. HS functions can be regulated by selective modifications and/or selective cleavage of the sugar chains from the cell surface. In mammals, heparanase (HPSE) is the only known enzyme capable of regulating HS functions via a selective endoglycosidase activity that cleaves polymeric HS chains at internal sites...
September 18, 2017: Pathogens
https://www.readbyqxmd.com/read/28926748/association-between-infection-burden-and-adult-height
#13
Dawson W Hedges, Andrew N Berrett, Lance D Erickson, Bruce L Brown, Shawn D Gale
Although highly heritable, adult height is also associated with numerous environmental factors, including exposure to infection. Particularly in developing regions of the world, infection burden appears to slow growth during childhood. Using a large database representative of the US population, we examined associations between adult height and leg length and an infection-burden index based on past exposure to Toxocara species, Toxoplasmosis gondii, cytomegalovirus, hepatitis A, hepatitis B, hepatitis C, herpes simplex virus 1, and herpes simplex virus 2...
September 2, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28924117/successful-treatment-of-herpes-simplex-virus-hsv-1-associated-hemophagocytic-lymphohistiocytosis-hlh-with-acyclovir-a-case-report-and-literature-review
#14
Tomohiro Yabushita, Satoshi Yoshioka, Yusuke Koba, Yuichirou Ono, Nobuhiro Hiramoto, Sumie Tabata, Munehiro Itou, Norio Shimizu, Keisuke Tomii, Takayuki Ishikawa
Hemophagocytic lymphohistiocytosis (HLH) associated with herpes simplex virus (HSV)-1 infection (HSV-1-HLH) is uncommon and is potentially fatal without appropriate treatment. We herein report the case of an adult patient with HSV-1-HLH who was successfully treated with acyclovir. A 69-year-old man developed fever, pancytopenia and liver enzyme elevation after the resolution of pneumonia. These findings and the presence of hemophagocytosis in the patient's bone marrow were consistent with a diagnosis of HLH...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28918039/crispr-cas9-mediated-knockin-application-in-cell-therapy-a-non-viral-procedure-for-bystander-treatment-of-glioma-in-mice
#15
Oscar Meca-Cortés, Marta Guerra-Rebollo, Cristina Garrido, Salvador Borrós, Nuria Rubio, Jeronimo Blanco
The use of non-viral procedures, together with CRISPR/Cas9 genome-editing technology, allows the insertion of single-copy therapeutic genes at pre-determined genomic sites, overcoming safety limitations resulting from random gene insertions of viral vectors with potential for genome damage. In this study, we demonstrate that combination of non-viral gene delivery and CRISPR/Cas9-mediated knockin via homology-directed repair can replace the use of viral vectors for the generation of genetically modified therapeutic cells...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28916522/viral-infection-sensitizes-human-fetal-membranes-to-bacterial-lipopolysaccharide-by-mertk-inhibition-and-inflammasome-activation
#16
Sarah N Cross, Julie A Potter, Paulomi Aldo, Ja Young Kwon, Mary Pitruzzello, Mancy Tong, Seth Guller, Carla V Rothlin, Gil Mor, Vikki M Abrahams
Chorioamnionitis, premature rupture of fetal membranes (FMs), and subsequent preterm birth are associated with local infection and inflammation, particularly IL-1β production. Although bacterial infections are commonly identified, other microorganisms may play a role in the pathogenesis. Because viral pandemics, such as influenza, Ebola, and Zika, are becoming more common, and pregnant women are at increased risk for associated complications, this study evaluated the impact that viral infection had on human FM innate immune responses...
September 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28916264/sidt2-transports-extracellular-dsrna-into-the-cytoplasm-for-innate-immune-recognition
#17
Tan A Nguyen, Blake R C Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang
Double-stranded RNA (dsRNA) is a common by-product of viral infections and acts as a potent trigger of antiviral immunity. In the nematode C. elegans, sid-1 encodes a dsRNA transporter that is highly conserved throughout animal evolution, but the physiological role of SID-1 and its orthologs remains unclear. Here, we show that the mammalian SID-1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartments into the cytoplasm for immune activation. Sidt2-deficient mice exposed to extracellular dsRNA, encephalomyocarditis virus (EMCV), and herpes simplex virus 1 (HSV-1) show impaired production of antiviral cytokines and-in the case of EMCV and HSV-1-reduced survival...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28916114/-scleritis-and-episcleritis
#18
REVIEW
E Héron, T Bourcier
Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28914852/-efficiency-of-immunosuppressive-therapy-in-virus-negative-and-virus-positive-patients-with-morphologically-verified-lymphocytic-myocarditis
#19
O V Blagova, A V Nedostup, E A Kogan, V A Sulimov
AIM: To evaluate the efficiency of immunosuppressive therapy (IST) in virus-negative (V-) and virus-positive (V+) patients with lymphocytic myocarditis (LM). SUBJECTS AND METHODS: 60 patients (45 males) (mean age 46.7±11.8 years) with dilated cardiomyopathy (mean left ventricular (LV) end diastolic size (EDS) 6.7±0.7 cm; ejection fraction (EF) 26.2±9.1%) were examined. The diagnosis of active/borderline LM was verified by right ventricular endomyocardial biopsy in 38 patients, by intraoperative LV biopsy in 10, in the study of explanted hearts from 3 patients and at autopsy in 9...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914079/co-infection-of-human-herpesvirus-type-2-hhv-2-and-human-immunodeficiency-virus-hiv-among-pregnant-women-in-rio-de-janeiro-brazil
#20
Lyana Rodrigues Pinto Lima, Luis Eduardo Barros Costa Fernandes, Daniel A M Villela, Mariza Gonçalves Morgado, José Henrique Pilotto, Vanessa Salete de Paula
Pregnant women who are infected with the Human Immunodeficiency Virus (HIV) are particularly vulnerable to severe and recurrent infections with Human Herpesvirus 2 (HHV-2). Neonatal transmission of HHV-2 has been associated with malformations and neurological sequelae in infants, which makes it very important to perform antenatal monitoring for genital herpes. In the study, 134 pregnant women infected with HIV were tested for HHV-2 IgM and IgG using an enzyme-linked immunosorbent assay (ELISA) and had HHV-2 DNA analyzed by Real Time Polymerase Chain Reaction (qPCR)...
September 15, 2017: AIDS Care
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