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https://www.readbyqxmd.com/read/29345511/clinical-characteristics-of-herpes-simplex-virus-associated-anterior-uveitis
#1
Barbara Wensing, Manabu Mochizuki, Joke H De Boer
PURPOSE: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis. METHODS: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. RESULTS: It was observed that HSV anterior uveitis is mostly an acute unilateral disease mainly occurring in middle-aged people with a predominance in females...
January 18, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29343258/mass-spectrometric-profiling-of-cerebrospinal-fluid-reveals-metabolite-biomarkers-for-cns-involvement-in-varicella-zoster-virus-reactivation
#2
Maike Kuhn, Kurt-Wolfram Sühs, Manas K Akmatov, Frank Klawonn, Junxi Wang, Thomas Skripuletz, Volkhard Kaever, Martin Stangel, Frank Pessler
BACKGROUND: Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation...
January 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29337348/expression-of-the-purine-biosynthetic-enzyme-phosphoribosyl-formylglycinamidine-synthase-fgams-in-neurons
#3
Colleen A Mangold, Pamela J Yao, Mei Du, Willard M Freeman, Stephen J Benkovic, Moriah L Szpara
Purines are metabolic building blocks essential for all living organisms on earth. De novo purine biosynthesis occurs in the brain and appears to play important roles in neural development. Phosphoribosyl formylglycinamidine synthase (FGAMS, also known as PFAS or FGARAT), a core enzyme involved in the de novo synthesis of purines, may play alternative roles in viral pathogenesis. To date, no thorough investigation of the endogenous expression and localization of de novo purine biosynthetic enzymes has been conducted in human neurons or in virally infected cells...
January 16, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29337163/utility-of-ultra-deep-sequencing-for-detection-of-varicella-zoster-virus-antiviral-resistance-mutations
#4
Mélanie Mercier-Darty, David Boutolleau, Raphaël Lepeule, Christophe Rodriguez, Sonia Burrel
We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. VZV is commonly acquired in youth whose primary infection usually manifests as benign varicella (chickenpox)...
January 11, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29334500/overexpression-of-%C3%A2%C2%B5-opioid-receptors-in-peripheral-afferents-but-not-in-combination-with-enkephalin-decreases-neuropathic-pain-behavior-and-enhances-opioid-analgesia-in-mouse
#5
Amanda H Klein, Husam K Mohammad, Rabiah Ali, Brad Peper, Steven P Wilson, Srinivasa N Raja, Matthias Ringkamp, Sarah Sweitzer
BACKGROUND: The current study used recombinant herpes simplex virus type I to increase expression of µ-opiate receptors and the opioid ligand preproenkephalin in peripheral nerve fibers in a mouse model of neuropathic pain. It was predicted that viral vector delivery of a combination of genes encoding the µ-opioid receptor and preproenkephalin would attenuate neuropathic pain and enhance opioid analgesia. The behavioral effects would be paralleled by changes in response properties of primary afferent neurons...
January 15, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29334246/screening-of-north-east-mexico-medicinal-plants-with-activities-against-herpes-simplex-virus-and-human-cancer-cell-line
#6
David Silva-Mares, Veronica M Rivas-Galindo, Ricardo Salazar-Aranda, Luis Alejandro Pérez-Lopez, Noemí Waksman De Torres, Jonathan Pérez-Meseguer, Ernesto Torres-Lopez
The plants examined in this study have previous biological activity reports indicating the possibility of found activity against herpes and cancer cell. The aim of this contribution was to carry out a screening of Juglans mollis (Juglandaceae), Persea americana (Lauraceae), Hamelia patens (Rubiaceae), Salvia texana (Lamiaceae), Salvia ballotaeflora (Lamiaceae), Ceanothus coeruleus (Rhamnaceae), Chrysactinia mexicana (Asteraceae) y Clematis drummondii (Ranunculaceae), against HeLa cells, VHS-1 and VHS-2. The method MTT was used to determine the 50% cytotoxic concentration (CC50), in Vero and HeLa cell lines...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334191/exogenous-oestrogen-inhibits-genital-transmission-of-cell-associated-hiv-1-in-dmpa-treated-humanized-mice
#7
Nirk E Quispe Calla, Rodolfo D Vicetti Miguel, Melissa E Glick, Jesse J Kwiek, Janelle M Gabriel, Thomas L Cherpes
INTRODUCTION: HIV affects more women than any other life-threatening infectious agent, and most infections are sexually transmitted. HIV must breach the female genital tract mucosal barrier to establish systemic infection, and clinical studies indicate virus more easily evades this barrier in women using depot-medroxyprogesterone acetate (DMPA) and other injectable progestins for contraception. Identifying a potential mechanism for this association, we learned DMPA promotes susceptibility of wild-type mice to genital herpes simplex virus type 2 (HSV-2) infection by reducing genital tissue expression of the cell-cell adhesion molecule desmoglein-1 (DSG-1) and increasing genital mucosal permeability...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29327237/regional-age-and-respiratory-secretion-specific-prevalence-of-respiratory-viruses-associated-with-asthma-exacerbation-a-literature-review
#8
REVIEW
Xue-Yan Zheng, Yan-Jun Xu, Wei-Jie Guan, Li-Feng Lin
Despite increased understanding of how viral infection is involved in asthma exacerbations, it is less clear which viruses are involved and to what extent they contribute to asthma exacerbations. Here, we sought to determine the prevalence of different respiratory viruses during asthma exacerbations. Systematic computerized searches of the literature up to June 2017 without language limitation were performed. The primary focus was on the prevalence of respiratory viruses, including AdV (adenovirus), BoV (bocavirus), CoV (coronavirus), CMV (cytomegalovirus), EnV (enterovirus), HSV (herpes simplex virus), IfV (influenza virus), MpV (metapneumovirus), PiV (parainfluenzavirus), RV (rhinovirus) and RSV (respiratory syncytial virus) during asthma exacerbations...
January 11, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29326371/mycoplasma-pneumoniae-infection-presenting-as-stroke-and-meningoencephalitis-with-aortic-and-subclavian-aneurysms-without-pulmonary-involvement
#9
Pournamy Sarathchandran, Abubaker Al Madani, Ayman M Alboudi, Jihad Inshasi
A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis. CSF PCR for herpes simplex and varicella zoster virus was negative. He developed acute right haemiplegia a week after hospitalisation. MRI showed acute infarct in the left centrum semiovale. His angiogram showed aneurysm in the left subclavian artery and aortic arch...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29322764/rapid-veterinary-diagnosis-of-bovine-reproductive-infectious-diseases-from-semen-using-paper-origami-dna-microfluidics
#10
Zhugen Yang, Gaolian Xu, Julien Reboud, Syed Atif Ali, Gurpreet Kaur, John McGiven, Nongthombam Boby, Praveen Gupta, Pallab Chaudhuri, Jonathan Mark Cooper
The health and well-being of cattle is a significant concern for global agricultural output. In dairy production within low and middle income countries (LMICs), there is a significant biosensing challenge in detecting sexually transmitted infection (STI) pathogens during animal husbandry, due in part to difficulties associated with the limited infrastructure for veterinary medicine. Here we demonstrate low-cost, multiplexed and sample-to-answer paper-origami tests for the detection of three bovine infectious reproductive diseases in semen samples, collected at a test site in rural India...
January 11, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29322275/outcome-of-polymerase-chain-reaction-pcr-analysis-in-100-suspected-cases-of-infectious-uveitis
#11
Ranju Kharel Sitaula, M K Janani, H N Madhavan, Jyotirmay Biswas
BACKGROUND: Polymerase chain reaction (PCR) analysis is an important tool in the diagnosis of infectious uveitis. A retrospective, interventional study of PCR analysis of ocular fluid in suspected infectious uveitis cases between January 2014 to July 2016 was done. Nested, real-time and broad range PCR was performed for detection of the genome of Mycobacterium tuberculosis, herpes virus family, Chikungunya virus, Toxoplasma gondii, fungus, eubacterium and propionibacterium acne. RESULTS: Total of 100 cases included, mean age was 39...
January 10, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29321311/herpes-simplex-virus-1-mutant-with-point-mutations-in-ul39-is-impaired-for-acute-viral-replication-in-mice-establishment-of-latency-and-explant-induced-reactivation
#12
Heba H Mostafa, Thornton W Thompson, Adam J Konen, Steve D Haenchen, Joshua G Hilliard, Stuart J Macdonald, Lynda A Morrison, David J Davido
In the process of generating HSV-1 mutants in the viral regulatory gene encoding infected cell protein 0 (ICP0), we isolated a viral mutant, termed KOS-NA, that was severely impaired for acute replication in the eyes and trigeminal ganglia (TG) of mice, defective in establishing a latent infection, and reactivated poorly from explanted TG. To identify the secondary mutation(s) responsible for the impaired phenotypes of this mutant, we sequenced the KOS-NA genome and noted that it contained two nonsynonymous mutations in UL39, which encodes the large subunit of ribonucleotide reductase, ICP6...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29317068/etiological-mechanism-of-iridocorneal-endothelial-ice-syndrome-may-involve-infection-of-herpes-simplex-virus-hsv-and-integration-of-viral-genes-into-human-genome
#13
Fei Li, Yaoming Liu, Yi Sun, Xiulan Zhang
Iridocorneal (ICE) syndrome is a rare ocular disease characterized by abnormal proliferation of corneal endothelial cells, progressive obstruction of irido-corneal angle and atrophy of iris. ICE syndrome progressed slowly, but can cause serious complications such as secondary glaucoma in late stage. Because the etiology of ICE syndrome is not clear, there is still no effective treatment in clinical practice. Previous studies have detected herpes simplex virus (HSV) DNA inside patient's aqueous humor. However, no further explanation for HSV-related etiology of ICE syndrome was established...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315637/rapid-detection-and-differentiation-of-carp-oedema-virus-and-cyprinid-herpes-virus-3-in-koi-and-common-carp
#14
H Soliman, M El-Matbouli
Carp oedema virus (CEV) and koi herpes virus (KHV) are of major concern to common carp breeders and koi enthusiasts worldwide. The viruses cause diseases that exhibit similar external signs; thus, it is difficult to distinguish between them clinically. In this study, we developed and optimized rapid and accurate single- and multiplex isothermal diagnostic tools, based on recombinase polymerase amplification (RPA), for detection and differentiation of CEV and KHV. The assays were combined with a lateral flow dipstick to enable visual detection of amplification products and simplify post-amplification analysis...
January 9, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29315221/introduction-of-exogenous-hsv-tk-suicide-gene-increases-safety-of-keratinocyte-derived-induced-pluripotent-stem-cells-by-providing-genetic-emergency-exit-switch
#15
Maciej Sułkowski, Paweł Konieczny, Paula Chlebanowska, Marcin Majka
Since their invention in 2006, induced Pluripotent Stem (iPS) cells remain a great promise for regenerative medicine circumventing the ethical issues linked to Embryonic Stem (ES) cell research. iPS cells can be generated in a patient-specific manner as an unlimited source of various cell types for in vitro drug screening, developmental biology studies and regenerative use. Having the capacity of differentiating into the cells of all three primary germ layers, iPS cells have high potential to form teratoma tumors...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29313728/the-potential-of-currently-unavailable-herpes-virus-vaccines
#16
Július Rajcáni, Ferenc Bánáti, Kálmán Szenthe, Susan Szathmary
Despite overwhelming experimental work, there are no licensed vaccines against the most frequent Alphaherpesviruses, namely herpes simplex virus 1 and 2 (HSV1 and 2) nor against the Epstein-Barr virus (EBV), a member of the subfamily Gammaherpesvirus. Areas covered: Since the DNAs of both HSVs reside in the regional sensory ganglia in a latent state (i.e. as circularized episomal molecules), a corresponding vaccine might be useful for immunotherapy rather than prevention of primary infection. Here we describe the design of a purified subunit vaccine (a mix of at least 3 glycoproteins) as well as the preparation and efficacy of a recombinant fusion protein consisting of the gD ectodomain from our domestic attenuated HSV1 strain HSZP...
January 9, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29313475/impact-of-antiretroviral-therapy-on-the-risk-of-herpes-zoster-among-human-immunodeficiency-virus-infected-individuals-in-tanzania
#17
Kosuke Kawai, Claudia A Hawkins, Ellen Hertzmark, Joel M Francis, David Sando, Aisa N Muya, Nzovu Ulenga, Wafaie W Fawzi
We examined the incidence of herpes zoster (HZ) before and after the initiation of antiretroviral therapy (ART), and risk factors for HZ among human immunodeficiency virus (HIV)-infected individuals in Tanzania. A cohort study was conducted among HIV-positive individuals enrolled in HIV care and treatment clinics in Dar es Salaam, Tanzania. A Cox proportional hazard model was used to examine the effect of ART on the risk of HZ after adjusting for sociodemographics and time-varying clinical and nutritional factors...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29306975/combination-of-mppa-pdt-and-hsv1-tk-gcv-gene-therapy-on-prostate-cancer
#18
Liming Liang, Wenxiang Bi, Weiwen Chen, Yani Lin, Yuanyuan Tian
We combined pyropheophorbide-a methyl ester, photodynamic therapy (MPPa-PDT), 670 ± 10 nm, 4 mW/cm2, with herpes simplex virus type 1 thymidine kinase/ganciclovir (HSV1-TK/GCV) to improve the therapeutic effect. We built HSV1-TK expression vector GV230-TK and we observed a bright green fluorescence under fluorescence microscope. It indicated the recombinant plasmid was transfected into PC-3M prostate cancer cells successfully. As the abundant glucose-regulated protein 78 (GRP78) promoter in PC-3M cells can cause active expression of HSV1-TK, cell protein was collected for western blot to determine the expression of HSV1-TK...
January 6, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29305707/transcriptional-retargeting-of-herpes-simplex-virus-for-cell-specific-replication-to-control-cancer
#19
REVIEW
Weihua Lou, Fang Ji, Jianing Fu, Zhiqiang Han, Wen Di, Ning Zhang
INTRODUCTION: Oncolytic virotherapy has emerged as a novel frontier in the treatment of cancer. Among the viruses that entered clinical trials are the oncolytic herpes simplex virus-1 (HSV-1). Current oncolytic HSV-1 approved for clinical practice, and those in clinical trials are attenuated viruses, often deleted in the neurovirulence gene γ134.5, and in additional genes, which may result in a much more attenuated virus with reduced replication efficiency. Therefore, the transcriptional retargeting strategy by modifying the regulator elements flanking essential viral genes to achieve tumor-specific replication while maintaining as much of the viral genome has been representing alternative promising oncolytic virotherapy modality...
January 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29305292/corneal-nerve-regeneration-after-herpes-simplex-keratitis-an-in-vivo-confocal-microscopy-study
#20
Hamid-Reza Moein, Ahmad Kheirkhah, Rodrigo T Muller, Andrea C Cruzat, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To evaluate the long-term alterations in corneal nerves in patients with herpes simplex virus (HSV) keratitis using in vivo confocal microscopy (IVCM). DESIGN: Prospective longitudinal, cross sectional. METHODS: This study included 16 patients with history of HSV keratitis and 15 age-matched normal controls. Slit-scanning IVCM was performed in all subjects at baseline and then after a mean follow-up of 37.3 ± 1.7 months in the patient group...
January 2, 2018: Ocular Surface
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