keyword
https://read.qxmd.com/read/38534949/wedge-resection-versus-stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer-tumors-%C3%A2-8-mm
#1
JOURNAL ARTICLE
Arian Mansur, Zain Saleem, Jorind Beqari, Camille Mathey-Andrews, Alexandra L Potter, James Cranor, Alexandra T Nees, Deepti Srinivasan, Margaret E Yang, Chi-Fu Jeffrey Yang, Hugh G Auchincloss
The objective of this study was to evaluate the overall survival of patients with ≤8 mm non-small cell lung cancer (NSCLC) who undergo wedge resection versus stereotactic body radiation therapy (SBRT). Kaplan-Meier analysis, multivariable Cox proportional hazards modeling, and propensity score-matched analysis were performed to evaluate the overall survival of patients with ≤8 mm NSCLC in the National Cancer Database (NCDB) from 2004 to 2017 who underwent wedge resection versus patients who underwent SBRT...
March 15, 2024: Current Oncology
https://read.qxmd.com/read/38531939/ultra-low-dose-computed-tomography-and-chest-x-ray-in-follow-up-of-high-grade-soft-tissue-sarcoma-a-prospective-comparative-study
#2
JOURNAL ARTICLE
Samuli Salminen, Sari Jäämaa, Riikka Nevala, Markus J Sormaala, Mika Koivikko, Erkki Tukiainen, Jussi Repo, Carl Blomqvist, Mika Sampo
Ultra-low-dose computed tomography (ULD-CT) may combine the high sensitivity of conventional computed tomography (CT) in detecting sarcoma pulmonary metastasis, with a radiation dose in the same magnitude as chest X-ray (CXR). Fifty patients with non-metastatic high-grade soft tissue sarcoma treated with curative intention were recruited. Their follow-up involved both CXR and ULD-CT to evaluate their different sensitivity. Suspected findings were confirmed by conventional CT if necessary. Patients with isolated pulmonary metastases were treated with surgery or stereotactic body radiation therapy (SBRT) with curative intent if possible...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38523881/radiation-therapy-for-optic-nerve-sheath-meningiomas-local-control-and-treatment-related-visual-changes
#3
JOURNAL ARTICLE
Jorge Alejandro Torres-Ríos, Alejandro Rodríguez-Camacho, Estefania Basilio-Tomé, Juan Marcos Meraz-Soto, Azyadeh Camacho-Ordonez, Gerardo Romero-Luna, Guillermo Axayacatl Gutierrez-Aceves, Irene González Olhovich, Miguel Angel Celis-López, Laura Crystell Hernández-Sánchez, Sergio Moreno-Jiménez
OBJECTIVE: Our primary objective is to evaluate the local control of optic nerve sheath meningiomas (ONSMs) treated with ionizing radiation and related visual changes after treatment. Our secondary objective is to describe the clinical characteristics and perform an analysis of the treatment impact on the functional status of this group of patients. METHODS: We present our series of 19 patients treated with ionizing radiation therapy at our radio-neurosurgery unit between 2016 and 2022...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38522767/pain-relief-related-structural-brain-alterations-in-trigeminal-neuralgia-induced-by-non-invasive-stereotactic-radiosurgery-a-pilot-study
#4
JOURNAL ARTICLE
Jonas Kolodziej, Bogdan Pintea, Jan Patrick Boström, Burkhard Pleger
PURPOSE: Trigeminal neuralgia (TN) is a devastating chronic pain disorder, defined by unilateral shock like pain in at least one division of the trigeminal nerve. Although several studies have investigated structural brain plasticity in TN patients, treatment-induced alterations remain largely uninvestigated. MATERIALS/METHODS: Combining T1-weighted magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) and multiple-regression analyses, we assessed gray matter maps of TN patients to investigate changes in gray matter volume (GMV) from before to half a year after stereotactic radiosurgery (SRS)...
March 22, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38522597/definitive-results-of-a-prospective-non-randomized-phase-2-study-on-stereotactic-body-radiation-therapy-sbrt-for-medically-inoperable-lung-and-liver-oligometastases-from-breast-cancer
#5
JOURNAL ARTICLE
D Franceschini, C Franzese, T Comito, M B Ilieva, R Spoto, A M Marzo, L Dominici, M Massaro, L Bellu, M Badalamenti, P Mancosu, M Scorsetti
BACKGROUND AND PURPOSE: To report mature results for local control and survival in oligometastatic (OM) breast cancer patients treated with stereotactic body radiotherapy (SBRT) on lung and/or liver lesions in a phase II trial. METHODS: This is a prospective non-randomized phase II trial (NCT02581670) which enrolled patients from 2015 to 2021. Eligibility criteria included: age > 18 years, ECOG 0-2, diagnosis of breast cancer, maximum of 4 lung/liver lesions (with a maximum diameter < 5 cm), metastatic disease confined to the lungs and liver or extrapulmonary or extrahepatic disease stable or responding to systemic therapy...
March 22, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38519913/an-international-phase-ii-trial-and-immune-profiling-of-sbrt-and-atezolizumab-in-advanced-pretreated-colorectal-cancer
#6
JOURNAL ARTICLE
Antonin Levy, Daphné Morel, Matthieu Texier, Roger Sun, Jerome Durand-Labrunie, Maria E Rodriguez-Ruiz, Severine Racadot, Stéphane Supiot, Nicolas Magné, Stacy Cyrille, Guillaume Louvel, Christophe Massard, Loic Verlingue, Fanny Bouquet, Alberto Bustillos, Lisa Bouarroudj, Clément Quevrin, Céline Clémenson, Michele Mondini, Lydia Meziani, Lambros Tselikas, Rastilav Bahleda, Antoine Hollebecque, Eric Deutsch
BACKGROUND: Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalities remain unclear. Here, we report the colorectal (CRC) cohort analysis from the SABR-PDL1 trial that evaluated the PD-L1 inhibitor atezolizumab in combination with stereotactic body radiation therapy (SBRT) in advanced cancer patients. METHODS: Eligible patients received atezolizumab 1200 mg every 3 weeks until progression or unmanageable toxicity, together with ablative SBRT delivered concurrently with the 2nd cycle (recommended dose of 45 Gy in 3 fractions, adapted upon normal tissue tolerance constraint)...
March 23, 2024: Molecular Cancer
https://read.qxmd.com/read/38516457/surgical-management-of-primary-thoracic-epidural-melanoma
#7
Taha Khalilullah, Giancarlo Mignucci-Jiménez, Henry Huffman, Hasita Karthikeyan, Zaheer Hanif, Ogechukwu Ariwodo, Ripul R Panchal
In this study, we reported one of the first cases where a rare robotic-assisted platform with neuronavigation technology and carbon-fiber-polyetheretherketone (CF/PEEK) screws is employed to surgically treat multilevel thoracic primary spinal epidural melanoma. A 67-year-old male presented with left upper thoracic pain. His magnetic resonance imaging (MRI) of the thoracic spine revealed a dumbbell-shaped left epidural mass at the T2-3 level. Partial resection was performed due to tumor growth into the vertebral bodies and patient discretion for minimal surgery...
February 2024: Curēus
https://read.qxmd.com/read/38516028/an-in-silico-planning-study-of-stereotactic-body-radiation-therapy-for-polymetastatic-patients-with-more-than-ten-extra-cranial-lesions
#8
JOURNAL ARTICLE
Federico Iori, Nathan Torelli, Jan Unkelbach, Stephanie Tanadini-Lang, Sebastian M Christ, Matthias Guckenberger
BACKGROUND AND PURPOSE: Limited data is available about the feasibility of stereotactic body radiation therapy (SBRT) for treating more than five extra-cranial metastases, and almost no data for treating more than ten. The aim of this study was to investigate the feasibility of SBRT in this polymetatstatic setting. MATERIALS AND METHODS: Consecutive metastatic melanoma patients with more than ten extra-cranial metastases and a maximum lesion diameter below 11 cm were selected from a single-center prospective registry for this in-silico planning study...
April 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38515641/vestibular-schwannoma-long-term-outcome-of-the-vestibular-function-after-stereotactic-radiosurgery
#9
JOURNAL ARTICLE
Lukas Anschuetz, Ekin Ermiş, Isabel Gebhart, Odile Stalder, Andreas Raabe, Georgios Mantokoudis, Marco Caversaccio, Evelyne Hermann, Franca Wagner, Dominique Vibert
OBJECTIVE: Evaluation at long term of the impact of the stereotactic surgery (SRS) on the vestibular function in vestibular schwannoma (VS) patients. STUDY DESIGN AND SETTING: Retrospective study in a tertiary referral center. PATIENTS: Fifty-one VS patients were included (34 females;17 males), aged from 41 to 78 years treated exclusively with SRS. INTERVENTION: Vestibular function was assessed before SRS and with median time interval of 14 (FU1) and 25 (FU2) months after treatment...
September 2023: Otol Neurotol Open
https://read.qxmd.com/read/38514580/upfront-stereotactic-radiosurgery-versus-adjuvant-radiosurgery-for-parasagittal-and-parafalcine-meningiomas-a-systematic-review-and-meta-analysis
#10
REVIEW
Fernando De Nigris Vasconcellos, Pavel Pichardo-Rojas, Augusto Muller Fieldler, Elad Mashiach, Brandon Santhumayor, Jowah Gorbachev, Hayes Fountain, Josh Bandopadhay, Timoteo Almeida, Jason Sheehan
Parafalcine and parasagittal (PFPS) are common locations for meningiomas. Surgical resection for these tumors, the first-line treatment, poses challenges due to their proximity to critical structures. This systematic review investigates the use of stereotactic radiosurgery (SRS) as a treatment for PFPS meningiomas, aiming to elucidate its safety and efficacy. The review adhered to PRISMA guidelines. Searches were conducted on MEDLINE, Embase, and Cochrane. Inclusion criteria involved studies on SRS for PFPS meningiomas, reporting procedure outcomes and complications...
March 22, 2024: Neurosurgical Review
https://read.qxmd.com/read/38511946/hypofractionated-stereotactic-radiosurgery-in-the-management-of-brain-metastases
#11
JOURNAL ARTICLE
Eric J Lehrer, William G Breen, Raj Singh, Joshua D Palmer, Paul D Brown, Daniel M Trifiletti, Jason P Sheehan
Stereotactic radiosurgery (SRS) is an important weapon in the management of brain metastases. Single-fraction SRS is associated with local control rates ranging from approximately 70% to 100%, which are largely dependent on lesion and postoperative cavity size. The rates of local control and improved neurocognitive outcomes compared with conventional whole-brain radiation therapy have led to increased adoption of SRS in these settings. However, when treating larger targets and/or targets located in eloquent locations, the risk of normal tissue toxicity and adverse radiation effects within healthy brain tissue becomes significantly higher...
March 21, 2024: Neurosurgery
https://read.qxmd.com/read/38511395/longitudinal-quality-of-life-after-sublobar-resection-and-stereotactic-body-radiation-therapy-for-early-stage-non-small-cell-lung-cancer
#12
JOURNAL ARTICLE
Juan P Wisnivesky, Jeremy Mudd, Kimberly Stone, Christopher G Slatore, Raja Flores, Scott Swanson, William Blackstock, Cardinale B Smith, Mark Chidel, Kenneth Rosenzweig, Claudia Henschke, Jeffrey A Kern
BACKGROUND: Many patients with early-stage lung cancer are not candidates for lobectomy because of various factors, with treatment options including sublobar resection or stereotactic body radiation therapy (SBRT). Limited information exists regarding patient-centered outcomes after these treatments. METHODS: Subjects with stage I-IIA non-small cell lung cancer (NSCLC) at high risk for lobectomy who underwent treatment with sublobar resection or SBRT were recruited from five medical centers...
March 21, 2024: Cancer
https://read.qxmd.com/read/38510980/mr-guided-stereotactic-radiation-therapy-for-head-and-neck-cancers
#13
JOURNAL ARTICLE
He Wang, Jinzhong Yang, Anna Lee, Jack Phan, Tze Yee Lim, Clifton D Fuller, Eun Young Han, Dong Joo Rhee, Travis Salzillo, Yao Zhao, Nitish Chopra, Mary Pham, Pam Castillo, Angela Sobremonte, Amy C Moreno, Jay P Reddy, David Rosenthal, Adam S Garden, Xin Wang
PURPOSE: MR-guided radiotherapy (MRgRT) has the advantage of utilizing high soft tissue contrast imaging to track daily changes in target and critical organs throughout the entire radiation treatment course. Head and neck (HN) stereotactic body radiation therapy (SBRT) has been increasingly used to treat localized lesions within a shorter timeframe. The purpose of this study is to examine the dosimetric difference between the step-and-shot intensity modulated radiation therapy (IMRT) plans on Elekta Unity and our clinical volumetric modulated arc therapy (VMAT) plans on Varian TrueBeam for HN SBRT...
May 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38510722/radiation-to-illuminate-the-path%C3%A2-of%C3%A2-neuromodulation-for-pulmonary%C3%A2-hypertension
#14
EDITORIAL
Karl-Philipp Rommel, Lukas Hobohm, Alexander M K Rothman, Philipp Lurz
No abstract text is available yet for this article.
February 2024: JACC. Basic to Translational Science
https://read.qxmd.com/read/38509654/reirradiation-of-metastases-of-the-central-nervous-system-part-1-brain-metastasis
#15
JOURNAL ARTICLE
Dirk Rades, Charles B Simone, Henry C Y Wong, Edward Chow, Shing Fung Lee, Peter A S Johnstone
Because of improved survival of cancer patients, more patients irradiated for brain metastases develop intracerebral recurrences requiring subsequent courses of radiotherapy. Five studies focused on reirradiation with whole-brain radiation therapy (WBRT) after initial WBRT for brain metastases. Following the second WBRT course, improvement of clinical symptoms was found in 31-68% of patients. Rates of neurotoxicity, such as encephalopathy or cognitive decline, were reported in two studies (1.4% and 32%). In another study, severe or unexpected adverse events were not observed...
March 20, 2024: Annals of Palliative Medicine
https://read.qxmd.com/read/38508239/cancer-specific-dose-and-fractionation-schedules-in-stereotactic-body-radiotherapy-for-oligometastatic-disease-an-interim-analysis-of-the-eortc-estro-e-2-radiate-oligocare-study
#16
JOURNAL ARTICLE
Sebastian M Christ, Filippo Alongi, Umberto Ricardi, Marta Scorsetti, Lorenzo Livi, Panagiotis Balermpas, Yolande Lievens, Pètra Braam, Barbara Alicja Jereczek-Fossa, Karin Stellamans, Ivica Ratosa, Joachim Widder, Heike Peulen, Piet Dirix, Samuel Bral, Sara Ramella, Hossein Hemmatazad, Kaouthar Khanfir, Xavier Geets, Paul Jeene, Thomas Zilli, Beatrice Fournier, Giovanni Battista Ivaldi, Enrico Clementel, Catherine Fortpied, Felix Boakye Oppong, Piet Ost, Matthias Guckenberger
BACKGROUND AND INTRODUCTION: Optimal dose and fractionation in stereotactic body radiotherapy (SBRT) for oligometastatic cancer patients remain unknown. In this interim analysis of OligoCare, we analyzed factors associated with SBRT dose and fractionation. MATERIALS AND METHODS: Analysis was based on the first 1,099 registered patients. SBRT doses were converted to biological effective doses (BED) using α/β of 10 Gy for all primaries, and cancer-specific α/β of 10 Gy for non-small cell lung and colorectal cancer (NSCLC, CRC), 2...
March 18, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38507097/feasibility-of-stereotactic-optical-navigation-for-needle-positioning-in-percutaneous-nephrolithotomy
#17
JOURNAL ARTICLE
I M Spenkelink, X Zhu, J J Fütterer, J F Langenhuijsen
BACKGROUND: This study assessed the feasibility of acquiring single-attempt access to the pelvicalyceal system during percutaneous nephrolithotomy (PCNL) using stereotactic optical navigation combined with cone-beam CT (CBCT) imaging. METHODS: Patients with a PCNL indication were prospectively included in this IRB approved study. After sterile preparation, fiducial markers were attached to patients' skin. An initial intraprocedural CBCT scan was acquired, on which the urologist planned the needle trajectory using the navigation software...
March 20, 2024: World Journal of Urology
https://read.qxmd.com/read/38504608/is-proton-beam-therapy-always-better-than-photon-irradiation-lessons-from-two-cases
#18
Michelle P Li, Adam Yeo, Roshini Gunewardena, Gabrielle Drum, Kirsty Wiltshire, Claire Phillips, Joseph Sia, Greg Wheeler, Lisa Hall
Proton beam therapy (PBT) is increasingly used to treat cancers, especially in the paediatric and adolescent and young adult (AYA) population. As PBT becomes more accessible, determining when PBT should be used instead of photon irradiation can be difficult. There is a need to balance patient, tumour and treatment factors when making this decision. Comparing the dosimetry between these two modalities plays an important role in this process. PBT can reduce low to intermediate doses to organs at risk (OAR), but photon irradiation has its dosimetric advantages...
March 20, 2024: Journal of Medical Radiation Sciences
https://read.qxmd.com/read/38503989/notch-appearance-as-a-novel-radiological-predictor-of-transient-expansion-and-good-outcome-of-expanding-schwannoma-after-radiotherapy
#19
JOURNAL ARTICLE
Masahiro Yamazaki, Shigeyuki Takamatsu, Yuta Iwata, Takayuki Sakurai, Masashi Taka, Satoshi Kobayashi, Toshifumi Gabata, Eiichi Mizuno
OBJECTIVES: Schwannoma expansion after radiotherapy has not been well-studied despite the clinical importance of distinguishing transient increase from permanent expansion. Thus, this study aimed to identify the underlying mechanism and novel radiological predictors of schwannoma expansion after radiotherapy. MATERIALS & METHODS: We retrospectively examined the therapeutic effects of radiotherapy on schwannomas and magnetic resonance images of 43 patients with vestibular schwannomas who underwent stereotactic radiotherapy or radiosurgery at our facility between June 1, 2012 and September 1, 2018...
March 19, 2024: Discover. Oncology
https://read.qxmd.com/read/38499253/simultaneous-focal-boost-with-stereotactic-radiotherapy-for-localised-intermediate-to-high-risk-prostate-cancer-primary-outcomes-of-the-sparc-phase-ii-trial
#20
JOURNAL ARTICLE
Binnaz Yasar, Yae-Eun Suh, Ewan Chapman, Luke Nicholls, Daniel Henderson, Caroline Jones, Kirsty Morrison, Emma Wells, Julia Henderson, Carole Meehan, Aslam Sohaib, Helen Taylor, Alison Tree, Nicholas Van As
PURPOSE: Dose escalated radiotherapy is associated with better biochemical control at the expense of toxicity. Stereotactic body radiotherapy (SBRT) with dose escalation to the dominant intraprostatic lesion (DIL) provides a logical approach to improve outcomes in high-risk disease whilst limiting toxicity. This study evaluated the toxicity and quality of life (QOL) with CyberKnife-based SBRT and simultaneous integrated boost in localised prostate cancer. METHODS AND MATERIALS: Eligible participants included newly diagnosed, biopsy-proven unfavourable intermediate to high risk localised prostate cancer (at least one of the following: Gleason ≥ 4+3, MRI defined T3a N0, PSA ≥ 20) with up to two MRI-identified DILs...
March 16, 2024: International Journal of Radiation Oncology, Biology, Physics
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