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Central apnea

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https://www.readbyqxmd.com/read/28087822/amygdala-and-hippocampus-are-symptomatogenic-zones-for-central-apneic-seizures
#1
Nuria Lacuey, Bilal Zonjy, Luisa Londono, Samden D Lhatoo
OBJECTIVE: To identify limbic sites of respiratory control in the human brain, and by extension, the symptomatogenic zone for central apnea. METHODS: We used direct stimulation of anatomically, precisely placed stereotactic EEG electrodes to analyze breathing responses. We prospectively studied 3 patients who were explored with stereotactically implanted depth electrodes. The amygdala and hippocampus, as well as extralimbic sites (orbitofrontal, temporal tip, and temporal neocortex), were investigated...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28081171/a-higher-proportion-of-metabolic-syndrome-in-chinese-subjects-with-sleep-disordered-breathing-a-case-control-study-based-on-electrocardiogram-derived-sleep-analysis
#2
Ping-Huei Tseng, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, Chung-Kang Peng
OBJECTIVE: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. METHODS: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea-hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour...
2017: PloS One
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#3
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28065692/respiratory-drive-in-patients-with-chronic-heart-failure-and-central-sleep-apnea-data-from-the-daunia-heart-failure-registry
#4
Michele Correale, Giovanna Elisiana Carpagnano, Natale Daniele Brunetti, Lucia Forte, Ilenia Monaco, Armando Ferraretti, Roberto Sabato, Maria Pia Foschino Barbaro, Matteo Di Biase, Donato Lacedonia
No abstract text is available yet for this article.
December 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#5
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28063152/dysfunction-of-central-control-of-breathing-in-amyotrophic-lateral-sclerosis
#6
Bradley N Howell, Daniel S Newman
Dysfunction in central control of breathing in some amyotrophic lateral sclerosis (ALS) patients is not adequately detected with standard evaluation for respiratory dysfunction. Nocturnal oximetry reveals periodic desaturations despite normal respiratory muscle movements. Continuous diaphragmatic electromyography has provided in vivo data consistent with impaired central control of diaphragm motor units. Current understanding of central control of breathing identifies the pre-Botzinger complex as the inspiratory rhythm generator...
January 7, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28057162/-prevalence-of-obstructive-sleep-apnea-hypopnea-syndrome-in-professional-drivers-and-the-relationship-with-traffic-accidents
#7
Y Liu, C L Tu, W F Yao, Y F Yu, Z Wang, J R Hu
Objective: To study the prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) and its relationship with traffic accidents in the professional drivers. Methods: Questionnaires of OSAHS were sent to 950 professional drivers who had annual physical examination at the Central Hospital of Jiading District in Shanghai from October 2014 to September 2015. Those with moderate to severe snoring and/or Epworth Sleepiness Scale (ESS)≥9 performed the home sleep testing. All drivers were divided into OSAHS and non-OSAHS according to the survey and monitoring...
December 27, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28054365/mapping-for-acute-transvenous-phrenic-nerve-stimulation-study-maps-study
#8
Lukas R C Dekker, Bart Gerritse, Avram Scheiner, Lilian Kornet
AIMS: Central Sleep Apnea Syndrome, correlated with the occurrence of heart failure, is characterized by periods of insufficient ventilation during sleep. This acute study in 15 patients aims to map the venous system and determine, if diaphragmatic movement can be achieved by phrenic nerve stimulation at various locations within the venous system. METHODS: Subjects underwent a scheduled catheter ablation procedure. During the procedural waiting time, one multi-electrode EP catheter was subsequently placed at the the superior and inferior vena cava and the junctions of the left jugular and left brachiocephalic vein and right jugular and right brachiocephalic vein, for phrenic nerve stimulation (1-2 seconds ON / 2-3 seconds OFF, 40 Hz, pulse width 210 μs)...
January 5, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28029639/sleep-disordered-breathing-exacerbates-muscle-vasoconstriction-and-sympathetic-neural-activation-in-patients-with-systolic-heart-failure
#9
Denise M L Lobo, Patricia F Trevizan, Edgar Toschi-Dias, Patricia A Oliveira, Rafael B Piveta, Dirceu R Almeida, Charles Mady, Edimar A Bocchi, Geraldo Lorenzi-Filho, Holly R Middlekauff, Carlos E Negrão
BACKGROUND: Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and hypoxia and hypercapnia episodes activate chemoreceptors stimulating autonomic reflex responses. We tested the hypothesis that muscle vasoconstriction and muscle sympathetic nerve activity (MSNA) in response to hypoxia and hypercapnia would be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD). METHODS AND RESULTS: Ninety consecutive patients with HF, New York Heart Association functional class II-III, and left ventricular ejection fraction ≤40% were screened for the study...
November 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28012784/positional-modification-techniques-for-supine-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#10
REVIEW
Hayley Barnes, Bradley A Edwards, Simon A Joosten, Matthew T Naughton, Garun S Hamilton, Eli Dabscheck
This review aimed to determine the effectiveness of positional modification techniques in preventing supine sleep, sleep-disordered breathing and other clinically important outcomes in patients with supine obstructive sleep apnea (OSA). Randomized controlled trials comparing positional modification techniques with any other therapy or placebo were included. Electronic searches of databases including CENTRAL, MEDLINE, CINAHL, Embase, and Web of Science up to April 2016 were performed. Meta-analysis was undertaken where possible...
November 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28007620/postoperative-oxygen-therapy-in-patients-with-obstructive-sleep-apnea-a-randomized-controlled-trial
#11
Pu Liao, Jean Wong, Mandeep Singh, David T Wong, Sazzadul Islam, Maged Andrawes, Colin M Shapiro, David P White, Frances Chung, Frances Chung
BACKGROUND: Surgical patients with obstructive sleep apnea (OSA) are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used but it may contribute to respiratory depression in OSA patients receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental oxygen on SaO2, sleep respiratory events, and CO2 level in patients with untreated OSA. METHODS: Consented patients with an apnea hypopnea index (AHI) >5 events/h on a preoperative polysomnography were randomized (1:1) to oxygen (O2) or no oxygen (Control)...
December 19, 2016: Chest
https://www.readbyqxmd.com/read/27992566/the-accuracy-of-portable-monitoring-in-diagnosing-significant-sleep-disordered-breathing-in-hospitalized-patients
#12
Swamy Nagubadi, Rohit Mehta, Mamoun Abdoh, Mohammedumer Nagori, Stephen Littleton, Renaud Gueret, Aiman Tulaimat
BACKGROUND: Polysomnograms are not always feasible when sleep disordered breathing (SDB) is suspected in hospitalized patients. Portable monitoring is a practical alternative; however, it has not been recommended in patients with comorbidities. OBJECTIVE: We evaluated the accuracy of portable monitoring in hospitalized patients suspected of having SDB. DESIGN: Prospective observational study. SETTING: Large, public, urban, teaching hospital in the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27986462/factors-contributing-to-unintentional-leak-during-cpap-treatment-a-systematic-review
#13
REVIEW
Marius Lebret, Jean-Benoit Martinot, Nathalie Arnol, Daniel Zerillo, Renaud Tamisier, Jean-Louis Pepin, Jean-Christian Borel
: Continuous positive airway pressure (CPAP) is the first-line treatment for moderate to severe obstructive sleep apnea syndrome (OSAS). Up to 25% of patients with OSAS discontinue CPAP treatment due to side effects. Unintentional leak and its associated annoying consequences are the most frequently reported adverse effects of CPAP. Successive technological improvements have not succeeded in addressing this issue. OBJECTIVES: A systematic review was conducted: (i) to assess the impact of different technological advances on unintentional leak and, (ii) to determine if any patient characteristics have already been identified as determinants of unintentional leak...
December 13, 2016: Chest
https://www.readbyqxmd.com/read/27975178/central-sleep-apnea-in-multiple-sclerosis-a-pilot-study
#14
Michael Lin, Arun V Krishnan, Danny J Eckert
PURPOSE: The purpose of the present study is to investigate sleep-disordered breathing and symptoms of sleepiness in a consecutive clinical cohort of multiple sclerosis (MS) patients. METHODS: Twenty-one (16 females) community-dwelling adults aged 18-75 years with MS and an Expanded Disability Status Scale score between 2 and 6 were recruited consecutively from an academic teaching hospital MS clinic. Participants performed a home sleep study (ResMed ApneaLink Plus) to objectively quantify sleep-disordered breathing...
December 14, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27959828/sleep-apnea-detection-based-on-thoracic-and-abdominal-movement-signals-of-wearable-piezo-electric-bands
#15
Yin-Yan Lin, Hau-Tieng Wu, Chi-An Hsu, Po-Chiun Huang, Yuan-Hao Huang, Yu-Lun Lo
Physiologically, the thoracic (THO) and abdominal (ABD) movement signals, captured using wearable piezo-electric bands, provide information about various types of apnea, including central sleep apnea (CSA) and obstructive sleep apnea (OSA). However, the use of piezo-electric wearables in detecting sleep apnea events has been seldom explored in the literature. This study explored the possibility of identifying sleep apnea events, including OSA and CSA, by solely analyzing one or both the THO and ABD signals...
December 7, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27938916/the-effect-of-sleep-apnea-on-all-cause-mortality-in-nondialyzed-chronic-kidney-disease-patients
#16
Jianwei Xu, In Young Yoon, Ho Jun Chin
BACKGROUND: The prevalence of sleep-disordered breathing (SDB) in people with chronic kidney disease (CKD) is high. Studies on the effects of sleep apnea (SA) on treatment outcomes have been mostly focused on dialyzed CKD or renal transplant patients. Studies on the effects of SA on all-cause mortality in nondialyzed CKD patients are scarce. METHODS: We enrolled and followed up all adults who were referred for diagnostic testing for sleep apnea between March 2007 and July 2014, had undergone polysomnography, and whose records of serum creatinine levels were available...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27938912/improvements-of-central-respiratory-events-cheyne-stokes-respiration-and-oxygenation-in-patients-hospitalized-for-acute-decompensated-heart-failure
#17
Kristina Basic, Henrik Fox, Jens Spießhöfer, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Sleep-disordered breathing (SDB), and Cheyne-Stokes respiration (CSR) in particular, are associated with reduced survival in patients with acute decompensated heart failure (ADHF). CSR cycle length (CL) has been shown to mirror heart failure severity and therefore may be a predictor of outcome. However, studies characterizing CSR in ADHF are rare and no study has investigated changes in CSR from admission to discharge in ADHF patients. METHODS: Consecutive patients admitted to our Academic Medical Center with ADHF were eligible...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27918326/anesthetic-considerations-for-patients-with-congenital-central-hypoventilation-syndrome-a-systematic-review-of-the-literature
#18
Saptashree M Basu, Frances F Chung, Shireen F AbdelHakim, Jean Wong
Congenital central hypoventilation syndrome (CCHS) is a form of sleep-disordered breathing characterized by a diminished drive to breathe during sleep, despite progressive hypercapnia and hypoxia. The condition results from mutations in the paired-like homeobox 2B (PHOX2B) gene. The aim of this review was to conduct a systematic search of the current data on CCHS as it relates to perioperative considerations and to discuss the classification, prevalence, pathophysiology, presentation, genetics, and management of the condition...
January 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27916076/-daytime-hypercapnia-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-in-han-and-uygur-nationality
#19
Z M He, X L Jiang, Piliqing Da, Z Ye, J P Li, Q L Zhang, Y Chen, J Shi, M Li, F Han
Objective: To evaluate the incidence and factors related to daytime hypercapnia in Han and Uygur patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: There were 221 patients with OSAHS (include 179 Han patients and 42 Uygur patients) in Sleep Center of Department of Respiratory and Critical Care Medicine of Karamay Central Hospital from 2015, Jan to Dec. All the patients underwent polysomnography (PSG), nocturnal oximetry, daytime blood gas analysis, pulmonary function test and Mouth occlusion pressure (P0...
November 29, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27909989/orexin-and-central-modulation-of-cardiovascular-and-respiratory-function
#20
Pascal Carrive, Tomoyuki Kuwaki
Orexin makes an important contribution to the regulation of cardiorespiratory function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate, sympathetic nerve activity, and the amplitude and frequency of respiration. This is consistent with the location of orexin neurons in the hypothalamus and the distribution of orexin terminals at all levels of the central autonomic and respiratory network. These cardiorespiratory responses are components of arousal and are necessary to allow the expression of motivated behaviors...
December 2, 2016: Current Topics in Behavioral Neurosciences
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