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https://www.readbyqxmd.com/read/29766677/sleeping-child-neuroendocrine-cell-hyperplasia-of-infancy-and-polysomnography
#1
Deborah R Liptzin, Stephen M M Hawkins, Brandie D Wagner, Robin R Deterding
OBJECTIVES: Neuroendocrine cell hyperplasia of infancy (NEHI) is a children's interstitial and diffuse lung disease of unknown etiology that presents in infancy with characteristic findings of tachypnea, retractions, crackles, and hypoxemia. At the present, the mainstay of treatment is oxygen supplementation to normalize oxygen saturations and decrease work of breathing. There are characteristic pulmonary function, radiographic, and histologic findings, but polysomnography (PSG) data has not been reported...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29750723/outcomes-of-sphincter-pharyngoplasty-in-the-cleft-population
#2
Ritwik Grover, Addison Barnett, Antonio Rampazzo, Frank Papay, Bahar Bassiri Gharb
INTRODUCTION: Sphincter pharyngoplasty (SP) is becoming increasingly popular for correction of velopharyngeal insufficiency (VPI) after cleft palate repair because of high success rate, low incidence of postoperative obstructive sleep apnea (OSA), and ease of revision in case of failure. This study is a meta-analysis of SP outcomes, reasons for failure, and revision strategies. METHODS: A comprehensive review of the literature on SP outcomes was conducted. Sphincter pharyngoplasty failure was defined as persistent hypernasality, incomplete velopharyngeal port (VP) closure on instrumental evaluation with concomitant VPI, or nonresolving hyponasality and/or OSA persisting >3 months after surgery...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29742297/advances-in-cellular-and-integrative-control-of-oxygen-homeostasis-within-the-central-nervous-system
#3
Jan-Marino Ramirez, Liza Severs, Sanja C Ramirez, Ibis M Agosto-Marlin
Mammals must continuously regulate the levels of O2 and CO2 , which is particularly important for the brain. Failure to maintain adequate O2 /CO2 homeostasis has been associated with numerous disorders including sleep apnea, Rett syndrome, and sudden infant death syndrome (SIDS). But, O2 /CO2 homeostasis poses major regulatory challenges, even in the healthy brain. Neuronal activities change in a differentiated, spatially and temporally complex manner, which is reflected in equally complex changes in O2 demand...
May 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29741725/ventilatory-control-sensitivity-in-patients-with-obstructive-sleep-apnea-is-sleep-stage-dependent
#4
Shane A Landry, Christopher Andara, Philip I Terrill, Simon A Joosten, Paul Leong, Dwayne L Mann, Scott A Sands, Garun S Hamilton, Bradley A Edwards
Study Objectives: The severity of obstructive sleep apnea (OSA) is known to vary according to sleep stage; however, the pathophysiology responsible for this robust observation is incompletely understood. The objective of the present work was to examine how ventilatory control system sensitivity (i.e. loop gain) varies during sleep in patients with OSA. Methods: Loop gain was estimated using signals collected from standard diagnostic polysomnographic recordings performed in 44 patients with OSA...
May 1, 2018: Sleep
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#5
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29735217/sustained-12-month-benefit-of-phrenic-nerve-stimulation-for-central-sleep-apnea
#6
Maria Rosa Costanzo, Piotr Ponikowski, Shahrokh Javaheri, Ralph Augostini, Lee R Goldberg, Richard Holcomb, Andrew Kao, Rami N Khayat, Olaf Oldenburg, Christoph Stellbrink, William T Abraham
Transvenous phrenic nerve stimulation improved sleep metrics and quality of life after 6 months versus control in the remedē System Pivotal Trial. This analysis explored the effectiveness of phrenic nerve stimulation in patients with central sleep apnea after 12 months of therapy. Reproducibility of treatment effect was assessed in the former control group in whom the implanted device was initially inactive for the sixth month and subsequently activated when the randomized control assessments were complete...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29734980/the-longest-obstructive-apnea-you-have-ever-seen-a-patient-with-new-onset-autonomic-dysfunction
#7
Puneet K Aulakh, David E Westerman, Raj C Dedhia
Autonomic dysfunction (AD) has been associated with both obstructive and central sleep apneas. Several mechanisms have been proposed for the emergence of sleep apnea in AD, which include impaired sensory input, compromised local reflexes, and altered central processing. We present a case of a 70-year-old woman who had experienced cardiac arrest four times related to hypoxic events due to the apparent sudden onset of obstructive sleep apnea (OSA) in the setting of AD. The episodes of OSA were profoundly prolonged and a tracheostomy was ultimately needed due to the inability of positive airway pressure therapy with supplemental oxygen to control events...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29731500/sleep-disordered-breathing-a-real-therapeutic-target-for-hypertension-pulmonary-hypertension-ischemic-heart-disease-and-chronic-heart-failure
#8
Takaaki Nakamoto
Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease in three middle- to large-sized randomized clinical trials: the SERVE-HF trial, which examined the effects of adaptive servo-ventilation (ASV) on patients with chronic heart failure (CHF) and central sleep apnea; the CAT-HF trial, which examined the effects of ASV therapy on patients with CHF after acute deterioration; and the SAVE study, which examined the secondary preventive effect of continuous positive airway pressure (CPAP) on patients with ischemic heart disease who had mild to moderate obstructive sleep apnea...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29719424/heart-rate-phenotypes-and-clinical-correlates-in-a-large-cohort-of-adults-without-sleep-apnea
#9
Zhaoyang Huang, Balaji Goparaju, He Chen, Matt T Bianchi
Background: Normal sleep is associated with typical physiological changes in both the central and autonomic nervous systems. In particular, nocturnal blood pressure dipping has emerged as a strong marker of normal sleep physiology, whereas the absence of dipping or reverse dipping has been associated with cardiovascular risk. However, nocturnal blood pressure is not measured commonly in clinical practice. Heart rate (HR) dipping in sleep may be a similar important marker and is measured routinely in at-home and in-laboratory sleep testing...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29717414/primary-central-sleep-apnea-and-anesthesia-a-retrospective-case-series
#10
Alexandru Alexa, Meghna P Mansukhani, Bhargavi Gali, Atousa Deljou, Juraj Sprung, Toby N Weingarten
PURPOSE: Primary (idiopathic) central sleep apnea (PCSA) is a rare central sleep-related breathing disorder characterized by increased chemoreceptor sensitivity to partial pressure of carbon dioxide, which manifests as hyperventilation followed by apnea during non-rapid eye movement sleep. The purpose of this retrospective study was to describe the postoperative course of patients who had PCSA and underwent procedures requiring anesthetic management. METHODS: Patients who received a diagnosis of PCSA at our institution and required procedural anesthesia between 1 January 2010 and 1 June 2016 underwent a comprehensive review of their health records with a focus on identifying respiratory complications...
May 1, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29713176/aberrant-brain-functional-connectome-in-patients-with-obstructive-sleep-apnea
#11
Li-Ting Chen, Xiao-Le Fan, Hai-Jun Li, Cheng-Long Ye, Hong-Hui Yu, Hui-Zhen Xin, Hong-Han Gong, De-Chang Peng, Li-Ping Yan
Objective: Obstructive sleep apnea (OSA) is accompanied by widespread abnormal spontaneous regional activity related to cognitive deficits. However, little is known about the topological properties of the functional brain connectome of patients with OSA. This study aimed to use the graph theory approaches to investigate the topological properties and functional connectivity (FC) of the functional connectome in patients with OSA, based on resting-state functional magnetic resonance imaging (rs-fMRI)...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29709336/short-term-metabolic-control-and-sleep-in-children-and-adolescents-with-type-1-diabetes-mellitus
#12
Martina Kostkova, Peter Durdik, Miriam Ciljakova, Jarmila Vojtkova, Anna Sujanska, Katarina Pozorciakova, Zuzana Snahnicanova, Maria Jancinova, Peter Banovcin
AIMS: The aim of this study was to examine sleep in T1D children and in healthy controls by polysomnographic (PSG) examination and to determine the influence of short-term metabolic compensation on sleep quality and sleep disordered breathing (SDB). METHODS: The prospective cross-sectional study included 44 T1D subjects and 60 healthy controls, aged 10-19 years. Subjects underwent anthropometric measurements, laboratory testing and standard overnight in-laboratory video polysomnography with continuous glucose monitoring (CGM)...
March 22, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29709333/gender-differences-in-morphological-and-functional-outcomes-after-mandibular-setback-surgery
#13
Khaled Dahy, Katsu Takahashi, Kazuyuki Saito, Honoka Kiso, Ibrahim Rezk, Toru Oga, Ryuji Uozumi, Kazuo Chin, Kazuhisa Bessho
PURPOSE: The aim of this study was to examine and compare morphological and functional outcomes after either isolated mandibular setback or bimaxillary surgery in males and females. MATERIALS AND METHODS: A retrospective study was done on 52 patients, in whom surgical correction for mandibular prognathism was performed either by isolated mandibular setback (30 cases) or by bimaxillary surgery (22 cases). Morphological changes were studied using cephalograms and functional changes studied using impulse oscillometry (IOS) taken before surgery (T0), 3 months (T1) and 1 year after surgery (T2)...
April 11, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29707357/transvenous-phrenic-nerve-stimulation-a-novel-therapeutic-approach-for-central-sleep-apnea
#14
REVIEW
Ning Ding, Xilong Zhang
Central sleep apnea (CSA) is common in heart failure (HF) patients. Traditional treatment of CSA, including continuous positive airway pressure (CPAP), adaptive servo ventilation (ASV), oxygen therapy, and CO2 inhalation, has respective limitations. Transvenous phrenic nerve stimulation (PNS), a novel therapeutic approach for CSA, was proved to be effective and safe. The remedē® system and related transvenous PNS methods was approved by FDA in 2017, for treating moderate to severe CSA.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29704303/atypical-presentations-associated-with-non-polyalanine-repeat-phox2b-mutations
#15
Umakanth Katwa, Alissa M D'Gama, Anita E Qualls, Lucas M Donovan, Jody Heffernan, Jiahai Shi, Pankaj B Agrawal
Congenital central hypoventilation syndrome (CCHS) is a disorder of ventilatory control and autonomic dysregulation that can be caused by mutations in the paired-like homeobox 2B (PHOX2B) gene. The majority of CCHS cases are caused by polyalanine repeat mutations (PARMs) in PHOX2B; however, in rare cases, non-polyalanine repeat mutations (NPARMs) have been identified. Here, we report two patients with NPARMs in PHOX2B. Patient 1 has a mild CCHS phenotype seen only on polysomnogram, which was performed for desaturations and stridor following a bronchiolitis episode, and characterized by night-time hypoventilation and a history of ganglioneuroblastoma...
April 28, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29701558/syringobulbia-in-pediatric-patients-with-chiari-malformation-type-i
#16
Arnold H Menezes, Jeremy D W Greenlee, Brian J Dlouhy
OBJECTIVE Syringobulbia (SB) is a rare entity, with few cases associated with Chiari malformation type I (CM-I) in the pediatric population. The authors reviewed all pediatric cases of CM-I-associated SB managed at their institution in order to better understand the presentation, treatment, and surgical outcomes of this condition. METHODS A prospectively maintained institutional database of craniovertebral junction abnormalities was analyzed to identify all cases of CM-I and SB from the MRI era (i.e., after 1984)...
April 27, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29701198/-a-case-of-severe-obstructive-sleep-apnea-hypopnea-syndrome-with-urinary-and-anal-incontinence
#17
Li Zhou, Ruoyun Ouyang, Ping Chen, Hong Luo, Hanmei Liu, Guiqian Liu
A case of a young male patient, who came to the Second Xiangya Hospital, Central South University because of snoring for 10 years and nocturnal gatism for half month, was analyzed retrospectively. He was diagnosed as obstructive sleep apnea hypopnea syndrome (OSAHS) finally. The patient had been diagnosed and treated as stroke in the local hospital, while urinary and anal incontinence were not relieved. It was a dilemma for him to be properly diagnosed and treated. Polysomnography in our hospital revealed apnea hypopnea index (AHI) at 44...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29696938/analysis-of-osas-incidence-and-influential-factors-in-middle-aged-and-elderly-patients-with-hypertension
#18
Shuang Wang, Xinqing Niu, Peipei Zhang, Dexing Su, Jing Zhang, Wei Liu
BACKGROUND: To investigate the detection rate and influencing factors of obstructive sleep apnea syndrome (OSAS) in middle-aged and elderly patients with hypertension. METHODS: A total of 440 patients with hypertension were selected as the research objects, all of them participated in the Berlin questionnaire survey, and the polysomnography (PSG) was performed on the patients with a high risk of OSAS. The detection rate of OSAS was analyzed, the clinical data between non-OSAS group and OSAS group were compared and stepwise linear regression and Logistic regression were used to analyze the related influencing factors to apnea hyponea index (AHI) and OSAS in hypertensive patients...
April 24, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29694990/respiratory-instability-and-hypoxemia-episodes-in-preterm-infants
#19
Eduardo Bancalari, Nelson Claure
Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. Some of these episodes are due to central apnea, but in ventilated infants, they are frequently due to contractions of the abdominal musculature that can splint the respiratory pump, resulting in periods of decreased lung volume and hypoventilation...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29690686/-impaired-hypoxic-ventilatory-response-and-related-factors-in-han-and-uygur-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#20
Z M He, H Guo, X L Jiang, J P Li, Q L Zhang, Y P Yang, X S Dong, Piliqing Da, J Shi, M Li, M C Shi, F Han
Objective: To investigate the respiratory central hypoxia response and its related factors in Han and Uygur patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: One hundred and sixty six OSAHS patients were selected from Jan. 2016 to Dec. 2016 in Department of Respiratory and Critical Care Medicine, Kelamayi Central Hospital, including 69 cases of Han nationality and 97 cases of Uygur nationality. Seventy-three healthy subjects of Uygur nationality were enrolled as the control group. All of them under went sleep monitoring, nocturnal oxygen saturation (SaO(2)), pulmonary function and respiratory central hypoxia response...
April 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
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