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mirna aneurysm

Hao Li, Jizong Zhao, Wen Wang, Lu Zhang, Qing Lan, Jiangfei Wang, Yong Cao, Jizong Zhao
BACKGROUND: Intracranial aneurysm (IA) is a cerebrovascular disorder characterized by an abnormally bulged artery in the brain and subarachnoid hemorrhage caused by IA rupture with a high ratio of fatality and morbidity. However, the genetic etiology of IA remains largely unknown. MATERIALS AND METHODS: A dysregulated lncRNA-associated competing endogenous RNA (ceRNA) network was constructed by utilizing sample-matched microRNA (miRNA), long non-coding RNA (lncRNA) and mRNA expression profiles in 12 saccular IA samples and paired control arteries...
October 14, 2016: World Neurosurgery
Yiming Zhang, Zhao Liu, Min Zhou, Changjian Liu
Aberrant smooth muscle cells (SMCs) play important roles in the formation of abdominal aortic aneurysm (AAA). Although the molecular mechanism of AAA formation has been investigated, there is a lack of understanding concerning the role of microRNAs (miRNAs) in AAA, which the current study aimed to address. Firstly, miRNA array analysis was performed in order to compare the miRNA profiles in a mouse model of AAA with those in normal control mice, and differentially expressed miRNAs were identified. miR-129-5p was selected for further analysis, and was used to transfect human SMCs...
October 2016: Experimental and Therapeutic Medicine
Sabina Licholai, Wojciech Szczeklik, Marek Sanak
BACKGROUND: Abdominal aortic aneurysms (AAA) are usually asymptomatic and mostly diagnosed incidentally. Aortic dilatation progresses along with the wall weakening and eventually leads to a life-threatening rupture. Currently, there are no effective screening biomarkers for AAA. MicroRNAs, a class of small non-coding RNA molecules, offer great potential as biomarkers because of their stability in the bloodstream and expression characteristic for different diseases. OBJECTIVE: To assess the circulating miR-29c-3p as a potential biomarker of AAA and to elucidate the biological functions of miR-29c-3p in terms of pathogenesis of aneurysms...
September 1, 2016: MicroRNA
Albert Busch, Suzanne M Eken, Lars Maegdefessel
Non-coding RNA (ncRNA) is a class of genetic, epigenetic and translational regulators, containing short and long transcripts with intriguing abilities for use as biomarkers due to their superordinate role in disease development. In the past five years many of these have been investigated in cardiovascular diseases (CVD), mainly myocardial infarction (MI) and heart failure. To extend this view, we summarize the existing data about ncRNA as biomarker in the whole entity of CVDs by literature-based review and comparison of the identified candidates...
June 2016: Annals of Translational Medicine
Stanley S Stylli, Alexios A Adamides, Rachel M Koldej, Rodney B Luwor, David S Ritchie, James Ziogas, Andrew H Kaye
OBJECTIVE MicroRNAs (miRNAs) regulate gene expression and therefore play important roles in many physiological and pathological processes. The aim of this pilot study was to determine the feasibility of extraction and subsequent profiling of miRNA from CSF samples in a pilot population of aneurysmal subarachnoid hemorrhage patients and establish if there is a distinct CSF miRNA signature between patients who develop cerebral vasospasm and those who do not. METHODS CSF samples were taken at various time points during the clinical management of a subset of SAH patients (SAH patient samples without vasospasm, n = 10; SAH patient samples with vasospasm, n = 10)...
April 29, 2016: Journal of Neurosurgery
Kimon Bekelis, Joanna S Kerley-Hamilton, Amy Teegarden, Craig R Tomlinson, Rachael Kuintzle, Nathan Simmons, Robert J Singer, David W Roberts, Manolis Kellis, David A Hendrix
OBJECTIVE The molecular mechanisms behind cerebral aneurysm formation and rupture remain poorly understood. In the past decade, microRNAs (miRNAs) have been shown to be key regulators in a host of biological processes. They are noncoding RNA molecules, approximately 21 nucleotides long, that posttranscriptionally inhibit mRNAs by attenuating protein translation and promoting mRNA degradation. The miRNA and mRNA interactions and expression levels in cerebral aneurysm tissue from human subjects were profiled...
February 26, 2016: Journal of Neurosurgery
Xian Wei Su, Anna Ho Yin Chan, Gang Lu, Marie Lin, Johnny Sze, Jing Ye Zhou, Wai Sang Poon, Qiang Liu, Vera Zhi Yuan Zheng, George Kwok Chu Wong
BACKGROUND: Aneurysmal subarachnoid hemorrhage (SAH) is a highly morbid and fatal condition with high rate of cognitive impairment and negative impact in quality of life among survivors. Delayed cerebral infarction (DCI) is one the major factors for these negative outcomes. In this study we compared the circulating microRNA profiles of SAH patients and healthy individuals, and the circulating microRNA profiles of SAH patients with and without DCI. METHODS: Peripheral blood samples on Day 7 after the onset of SAH were subjected to microarray analysis with Affymetrix miRNA 3...
2015: PloS One
Ondřej Volný, Linda Kašičková, Dominika Coufalová, Petra Cimflová, Jan Novák
Cardiovascular diseases are major causes of morbidity and mortality in developed countries. Cerebrovascular diseases, especially stroke, represent major burden of disability and economy impact. Major advances in primary and secondary prevention and therapy are needed in order to tackle this public health problem. Our better understanding of pathophysiology is essential in order to develop novel diagnostic and therapeutic tools and strategies. microRNAs are a family of important post-transcriptional regulators of gene expression and their involvement in the pathophysiology of cerebrovascular diseases has already been reported...
2015: Advances in Experimental Medicine and Biology
André Jakob, Jane Whelan, Matthaeus Kordecki, Reinhard Berner, Brigitte Stiller, Raoul Arnold, Rudiger von Kries, Elena Neumann, Nicholas Roubinis, Mirna Robert, Jochen Grohmann, René Höhn, Markus Hufnagel
BACKGROUND: National estimates of Kawasaki disease (KD) incidence often do not include incomplete cases (diagnosed based on only laboratory or echocardiographic criteria), and/or they rely on retrospective case reports and data registries where underreporting is known to be a problem. METHODS: We conducted a prospective nationwide KD surveillance study in children younger than 5 years through the hospital-based German Pediatric Surveillance Unit (ESPED). We accounted for underreporting through applying capture-recapture methodology in 2 federal states using hospital discharge records with KD International Statistical Classification of Diseases and Related Health Problems 10th revision code (ie, M30...
February 2016: Pediatric Infectious Disease Journal
Xian-ming Fu, Yang-zhao Zhou, Zhao Cheng, Xiao-bo Liao, Xin-min Zhou
An aortic aneurysm (AA) is a common disease with potentially life-threatening complications. Despite significant improvements in the diagnosis and treatment of AA, the associated morbidity and mortality remain high. MicroRNAs (miRNAs, miR) are small noncoding ribonucleic acids that negatively regulate gene expression at the posttranscriptional level by inhibiting mRNA translation or promoting mRNA degradation. miRNAs are recently reported to be critical modulators for vascular cell functions such as cell migration, contraction, differentiation, proliferation, and apoptosis...
2015: BioMed Research International
X T Sima, J G Xu, J Li, C You
Vascular inflammation has been shown to be involved in the pathogenesis of intracranial aneurysms (IA). MiRNAs are key molecules that participate in the regulation of many important biological processes including inflammation. Studies on the hsa-miR-146a rs2910164 polymorphism and its association with different inflammatory related diseases have engendered inconsistent results, and until now, there have been no reports on the association between this polymorphism and the susceptibility to IA. In this study, we aimed to investigate whether the rs2910164 polymorphism is involved in the process of IA...
2015: Genetics and Molecular Research: GMR
Athanassios Kotsinas, Fragkiska Sigala, Spiros D Garbis, Giorgos Galyfos, Konstantinos Filis, Konstantinos Vougas, Alexandros Papalampros, Elizabeth E Johnson, Efstathios Chronopoulos, Alexandros G Georgakilas, Vassilis G Gorgoulis
Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role...
2015: Current Medicinal Chemistry
Rong Wei, Rufang Zhang, Yewei Xie, Li Shen, Fang Chen
BACKGROUND & AIMS: Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and the involved mechanisms using an in vitro experimental model of hypoxia/reoxygenation (H/R) on HT-22 cells...
2015: Cellular Physiology and Biochemistry
Rafaelle Spear, Ludovic Boytard, Renaud Blervaque, Maggy Chwastyniak, David Hot, Jonathan Vanhoutte, Bart Staels, Yves Lemoine, Nicolas Lamblin, François-René Pruvot, Stephan Haulon, Philippe Amouyel, Florence Pinet
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with marked changes in the cellular composition of the aortic wall. This study aims to identify microRNA (miRNA) expression in aneurysmal inflammatory cells isolated by laser microdissection from human tissue samples. The distribution of inflammatory cells (neutrophils, B and T lymphocytes, mast cells) was evaluated in human AAA biopsies. We observed in half of the samples that adventitial tertiary lymphoid organs (ATLOs) with a thickness from 0...
2015: International Journal of Molecular Sciences
Søren Bache, Rune Rasmussen, Maria Rossing, Niels Risør Hammer, Marianne Juhler, Lennart Friis-Hansen, Finn Cilius Nielsen, Kirsten Møller
BACKGROUND: Secondary brain injury accounts for a major part of the morbidity and mortality in patients with spontaneous aneurysmal subarachnoid hemorrhage (SAH), but the pathogenesis and pathophysiology remain controversial. MicroRNAs (miRNAs) are important posttranscriptional regulators of complementary mRNA targets and have been implicated in the pathophysiology of other types of acute brain injury. Cerebral microdialysis is a promising tool to investigate these mechanisms. We hypothesized that miRNAs would be present in human cerebral microdialysate...
2015: Journal of Translational Medicine
Wenwen Zhang, Tao Shang, Chen Huang, Tong Yu, Chen Liu, Tong Qiao, Dian Huang, Zhao Liu, Changjian Liu
OBJECTIVES: Abdominal aortic aneurysm (AAA) is often asymptomatic until rupture occurs. Although ultrasound screening has significantly improved the early diagnosis of AAA, the timely biomarker-based diagnosis of AAA remains a major clinical challenge. In this study, we aimed to assess plasma microRNAs (miRNAs) as promising novel biomarkers in patients with AAA. METHODS: Pooled plasma samples from 10 AAA and 10 healthy controls were profiled by microarray. The differentially expressed miRNAs were evaluated in a separate cohort of 120 subjects, including 60 AAA patients and 60 normal controls...
October 2015: Clinical Biochemistry
P W Stather, N Sylvius, D A Sidloff, N Dattani, A Verissimo, J B Wild, H Z Butt, E Choke, R D Sayers, M J Bown
BACKGROUND: MicroRNAs are crucial in the regulation of cardiovascular disease and represent potential therapeutic targets to decrease abdominal aortic aneurysm (AAA) expansion. The aim of this study was to identify circulating microRNAs associated with AAA. METHODS: Some 754 microRNAs in whole-blood samples from 15 men with an AAA and ten control subjects were quantified using quantitative reverse transcriptase-PCR. MicroRNAs demonstrating a significant association with AAA were validated in peripheral blood and plasma samples of men in the following groups (40 in each): healthy controls, controls with peripheral arterial disease (PAD), men with a small AAA (30-54 mm), those with a large AAA (over 54 mm), and those following AAA repair...
June 2015: British Journal of Surgery
Lars Maegdefessel, Joshua M Spin, Uwe Raaz, Suzanne M Eken, Ryuji Toh, Junya Azuma, Matti Adam, Futoshi Nakagami, Futoshi Nagakami, Helen M Heymann, Ekaterina Chernogubova, Ekaterina Chernugobova, Hong Jin, Joy Roy, Rebecka Hultgren, Kenneth Caidahl, Sonja Schrepfer, Anders Hamsten, Per Eriksson, Michael V McConnell, Ronald L Dalman, Philip S Tsao
Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models of AAA disease along with human aortic tissue and plasma analysis, that miR-24 is a key regulator of vascular inflammation and AAA pathology. In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells...
2014: Nature Communications
Dehua Liu, Liang Han, Xiao Wu, Xinjian Yang, Qunye Zhang, Fan Jiang
BACKGROUND: Intracranial aneurysms are pathological dilatations of the cerebral artery, while rupture of intracranial aneurysms causes life-threatening subarachnoid hemorrhage. The molecular mechanisms of pathogenesis of intracranial aneurysms are poorly understood. MicroRNAs have fundamental roles in modulating vascular biology and disease. In the present study, we carried out a genome-wide characterization on expressions of microRNAs, and performed integrative analyses in conjunction with changes of the transcriptome in human intracranial aneurysms...
2014: BMC Neurology
Pengxiang Li, Qunye Zhang, Xiao Wu, Xinjian Yang, Yun Zhang, Youxiang Li, Fan Jiang
BACKGROUND: Biological markers that can be used to predict the risk of intracranial aneurysms (IAs) are not available. METHODS AND RESULTS: To clarify whether circulating microRNAs could be used as biomarkers for IA, we carried out microarray assays in a screening cohort of 40 IA patients (20 unruptured and 20 ruptured) and 20 healthy volunteers. We identified 20 microRNAs that were unanimously changed in both ruptured and unruptured patients. We confirmed 60% of these changed microRNAs by a separate microarray test with an independent validation cohort (n=143 including 93 IA patients)...
October 2014: Journal of the American Heart Association
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