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https://www.readbyqxmd.com/read/27754528/-clinical-trials-and-licensing-of-monoclonal-antibodies-and-biological-medicines-for-cancer-treatment-in-brazil
#1
Cecilia Ferreira da Silva, Miriam Ventura da Silva, Claudia Garcia Serpa Osorio-de-Castro
Objective To analyze the pathway of clinical trials of monoclonal antibodies and biological medicines for cancer treatment involving Brazilian institutions from 2003 to 2012. Method This retrospective, descriptive study was based on review of two clinical trial registries, ClinicalTrials.gov and the Brazilian registry ReBEC. Phase II or III studies with participation from Brazilian institutions listed in at least one of the registries were included. Following selection of the trials, the pathway of monoclonal antibodies and biological medicines was investigated from the research stage until licensing by the Brazilian Agency for Sanitary Surveillance (Anvisa), Food and Drug Administration (FDA), and European Medicines Agency (EMA)...
March 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27717404/composition-and-cytotoxic-and-antioxidant-activities-of-the-oil-of-piper-aequale-vahl
#2
Joyce Kelly R da Silva, Laine C Pinto, Rommel M R Burbano, Raquel C Montenegro, Eloísa Helena A Andrade, José Guilherme S Maia
BACKGROUND: Piper aequale Vahl is a small shrub that grows in the shadow of large trees in the Carajás National Forest, Municipality of Parauapebas, Para state, Brazil. The local people have used the plant against rheumatism and inflammation. METHODS: The essential oil of the aerial parts was extracted and analyzed by GC and GC-MS. The MTT colorimetric assay was used to measuring the cytotoxic activity of the oil against human cancer lines. The determination of antioxidant activity of the oil was conducted by DPPH radical scavenging assay...
October 7, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27678324/stomach-cancer-burden-in-central-and-south-america
#3
Monica S Sierra, Patricia Cueva, Luis Eduardo Bravo, David Forman
RATIONALE AND OBJECTIVE: Stomach cancer mortality rates in Central and South America (CSA) are among the highest in the world. We describe the current burden of stomach cancer in CSA. METHODS: We obtained regional and national-level cancer incidence data from 48 population-based registries (13 countries) and nation-wide cancer deaths from WHO's mortality database (18 countries). We estimated world population age-standardized incidence (ASR) and mortality (ASMR) rates per 100,000 and estimated annual percent change to describe time trends...
September 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27605887/trends-and-predictions-for-gastric-cancer-mortality-in-brazil
#4
Angela Carolina Brandão de Souza Giusti, Pétala Tuani Candido de Oliveira Salvador, Juliano Dos Santos, Karina Cardoso Meira, Amanda Rodrigues Camacho, Raphael Mendonça Guimarães, Dyego L B Souza
AIM: To analyze the effect of age-period and birth cohort on gastric cancer mortality, in Brazil and across its five geographic regions, by sex, in the population over 20 years of age, as well as make projections for the period 2010-2029. METHODS: An ecological study is presented herein, which distributed gastric cancer-related deaths in Brazil and its geographic regions. The effects of age-period and birth cohort were calculated by the Poisson regression model and projections were made with the age-period-cohort model in the statistical program R...
July 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27293395/hiatal-hernia-as-a-total-gastrectomy-complication
#5
Bruna do Nascimento Santos, Marcos Belotto de Oliveira, Renata D'Alpino Peixoto
INTRODUCTION: According to the Brazilian National Institute of Cancer, gastric cancer is the third leading cause of death among men and the fifth among women in Brazil. Surgical resection is the only potentially curative treatment. The most serious complications associated with surgery are fistulas and dehiscence of the jejunal-esophageal anastomosis. Hiatal hernia refers to herniation of elements of the abdominal cavity through the esophageal hiatus of the diaphragm, though this occurrence is rarely reported as a complication in gastrectomy...
January 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27281504/esophageal-carcinoma-is-squamous-cell-carcinoma-different-disease-compared-to-adenocarcinoma-a-transversal-study-in-a-quaternary-high-volume-hospital-in-brazil
#6
Francisco Tustumi, Flavio Roberto Takeda, Cintia Mayumi Sakurai Kimura, Rubens Antônio Aissar Sallum, Ulysses Ribeiro, Ivan Cecconello
BACKGROUND: Esophageal cancer is one of the leading causes of mortality among the neoplasms that affect the gastrointestinal tract. There are several factors that contribute for development of an epidemiological esophageal cancer profile in a population. OBJECTIVE: This study aims to describe both clinically and epidemiologically the population of patients with diagnosis of esophageal cancer treated in a quaternary attention institute for cancer from January, 2009 to December, 2011, in Sao Paulo, Brazil...
January 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27192129/cdh1-mutations-in-gastric-cancer-patients-from-northern-brazil-identified-by-next-generation-sequencing-ngs
#7
Antonette El-Husny, Milene Raiol-Moraes, Marcos Amador, André M Ribeiro-Dos-Santos, André Montagnini, Silvanira Barbosa, Artur Silva, Paulo Assumpção, Geraldo Ishak, Sidney Santos, Pablo Pinto, Aline Cruz, Ândrea Ribeiro-Dos-Santos
Gastric cancer is considered to be the fifth highest incident tumor worldwide and the third leading cause of cancer deaths. Developing regions report a higher number of sporadic cases, but there are only a few local studies related to hereditary cases of gastric cancer in Brazil to confirm this fact. CDH1 germline mutations have been described both in familial and sporadic cases, but there is only one recent molecular description of individuals from Brazil. In this study we performed Next Generation Sequencing (NGS) to assess CDH1 germline mutations in individuals who match the clinical criteria for Hereditary Diffuse Gastric Cancer (HDGC), or who exhibit very early diagnosis of gastric cancer...
May 13, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27104022/sentinel-lymph-node-navigation-surgery-for-early-gastric-cancer-is-it-a-safe-procedure-in-countries-with-non-endemic-gastric-cancer-levels-a-preliminary-experience
#8
Guilherme Pinto Bravo Neto, Elizabeth Gomes Dos Santos, Felipe Carvalho Victer, Marcelo Soares Neves, Márcia Ferreira Pinto, Carlos Eduardo De Souza Carvalho
PURPOSE: Early diagnosis of gastric cancer is still the exception in Western countries. In the East, as in Japan and Korea, this disease is an endemic disorder. More conservative surgical procedures are frequently performed in early gastric cancer cases in these countries where sentinel lymph node navigation surgery is becoming a safe option for some patients. This study aims to evaluate preliminary outcomes of patients with early gastric cancer who underwent sentinel node navigation surgeries in Brazil, a country with non-endemic gastric cancer levels...
March 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/26840466/helicobacter-pylori-infection-in-patients-with-different-gastrointestinal-diseases-from-northern-brazil
#9
Igor Dias Ferreira Vinagre, André Lima de Queiroz, Mário Ribeiro da Silva Júnior, Ruth Maria Dias Ferreira Vinagre, Luisa Caricio Martins
BACKGROUND: The mechanisms whereby Helicobacter pylori produces different pathological manifestations in the stomach and duodenum are not fully understood. Considering the geographic diversity in the prevalence of virulence factors of this microorganism and their association with the development of different diseases, the search for pathogenicity markers such as CagA and VacA alleles by molecular techniques has intensified. OBJECTIVES: To investigate the presence of H...
December 2015: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/26345936/thymidylate-synthase-and-methylenetetrahy-drofolate-reductase-gene-polymorphisms-and-gastric-cancer-susceptibility-in-a-population-of-northern-brazil
#10
M D Araújo, B N Borges, S Rodrigues-Antunes, R M R Burbano, M L Harada
The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and methylenetetrahydrofolate reductase (MTHFR) 677C> T] in 2 genes related to the folate pathway, TS and MTHFR, and their possible association with the risk gastric cancer development in a population from Pará state, Brazil...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26229705/gastric-cancer-in-the-excluded-stomach-10-years-after-gastric-bypass
#11
Augusto Tinoco, Lorena F Gottardi, Eduardo D Boechat
According to the Brazilian health authorities, around 2,000 new cases of gastric cancer emerge in Brazil per year (Instituto Nacional de Câncer José Alencar Gomes da Silva, 2014). Indeed, gastric cancer constitutes the second most common cause of cancer-related mortality worldwide and 95% of such malignancies are adenocarcinomas (De Roover et al., 2006, and Clark et al., 2006). Roux-en-Y gastric bypass (RYGB) is a procedure frequently employed in bariatric surgery but restricted access to the excluded stomach means that discovery of gastric lesions is difficult, and diagnosis and treatment may be delayed...
2015: Case Reports in Surgery
https://www.readbyqxmd.com/read/26225668/individualized-chemotherapy-for-metastatic-gastric-cancer-retrospective-data-from-a-university-hospital-in-brazil
#12
Pedro Nazareth Aguiar Junior, Christian Ribas, Nora Manoukian Forones
BACKGROUND: Despite the decreased incidence, gastric cancer is still a frequent cause of cancer related death. The 1st line 2 or 3 drugs regimen is still a debatable issue. HER2 targeted therapy has emerged as the standard of care, but it is unavailable in the Brazilian Public Health System. The end-point of this trial was overall survival (OS) in patients with metastatic gastric cancer treated in a public university hospital in Brazil. The secondary end-points were efficacy and safety of regimens with 2 (F+P) or 3 (EOX) drugs to develop an institutional guideline to facilitate optimal treatments...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26039838/a-phase-ii-trial-exploring-the-extensive-intra-operative-peritoneal-lavage-eipl-as-a-prophylactic-strategy-for-peritoneal-recurrence-in-locally-advanced-gastric-cancer-reporting-postoperative-morbidity-and-mortality-after-early-closure
#13
MULTICENTER STUDY
Thales Paulo Batista, Mário Rino Martins, Euclides Dias Martins-Filho, Rogerio Luiz Dos Santos
BACKGROUND: The Extensive Intraoperative Peritoneal Lavage (EIPL) has been proposed as a practical prophylactic strategy to decrease the risk of peritoneal metastasis in gastric cancer. OBJECTIVE: To explore the safety and efficacy of the EIPL in our locally advanced gastric cancer patients. METHODS: This study is an open-label, double-center, single-arm phase II clinical trial developed at two tertiary hospitals from Recife (Pernambuco, Brazil)...
April 2015: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/26032078/-screening-of-the-anti-tumor-active-fraction-from-ipomoea-batatas-lam-cv-simon-leaves
#14
Shuhe Lü, Cong Lin, Pingsheng Xu
OBJECTIVE: Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated. METHODS: The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively. RESULTS: The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity...
May 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/25980424/involvement-of-monoaminergic-systems-in-the-antidepressant-like-properties-of-lafoensia-pacari-a-st-hil
#15
Pablinny M Galdino, Adryano A V Carvalho, Iziara F Florentino, José L R Martins, Andressa C Gazola, José R de Paula, Joelma A M de Paula, Luce M B Torres, Elson A Costa, Thereza Christina M de Lima
ETHNOPHARMACOLOGICAL RELEVANCE: Lafoensia pacari A. St.-Hil. (Lythraceae), known popularly as "pacari" or "mangaba-brava" is popularly used in the state of Goiás, Brazil. The stem bark or leaves are used to treat cancer, gastric disorders, inflammation and as a tonic to treat loss of enthusiasm. AIM OF THE STUDY: Previous results suggest that the ethanol:water 7:3 extract of the stem bark of L. pacari (PEx) has antidepressant-like activity in male mice. Our aim was to perform the PEx׳s bioguided fractionation and evaluate the monoaminergic system involvement in the antidepressant effect as well as progress in the study of L...
July 21, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25616434/olaparib-first-global-approval
#16
REVIEW
Emma D Deeks
Olaparib (Lynparza™) is an oral, small molecule, poly (ADP-ribose) polymerase inhibitor being developed by AstraZeneca for the treatment of solid tumours. The primary indication that olaparib is being developed for is BRCA mutation-positive ovarian cancer. A capsule formulation of the drug has received approval for use in this setting in the EU and USA, and a tablet formulation is in global phase III trials (including in the USA, EU, Australia, Brazil, Canada, China, Israel, Japan, Russia and South Korea)...
February 2015: Drugs
https://www.readbyqxmd.com/read/25494468/caga-phosphorylation-epiya-c-motifs-and-the-vaca-i-genotype-in-helicobacter-pylori-strains-of-asymptomatic-children-from-a-high-risk-gastric-cancer-area-in-northeastern-brazil
#17
Lucia Libanez Bessa Campelo Braga, Maria Aparecida Alves de Oliveira, Maria Helane Rocha Batista Gonçalves, Fernando Kennedy Chaves, Tiago Gomes da Silva Benigno, Adriana Dias Gomes, Cícero Igor Simões Moura Silva, Charles Anacleto, Sérgio de Assis Batista, Dulciene Maria Magalhães Queiroz
Helicobacter pylori infection is one of the most common infections worldwide and is associated with gastric diseases. Virulence factors such as VacA and CagA have been shown to increase the risk of these diseases. Studies have suggested a causal role of CagA EPIYA-C in gastric carcinogenesis and this factor has been shown to be geographically diverse. We investigated the number of CagA EPIYA motifs and the vacA i genotypes in H. pylori strains from asymptomatic children. We included samples from 40 infected children (18 females and 22 males), extracted DNA directly from the gastric mucus/juice (obtained using the string procedure) and analysed the DNA using polymerase chain reaction and DNA sequencing...
December 2014: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/25318991/occurrence-of-helicobacter-pylori-and-epstein-barr-virus-infection-in-endoscopic-and-gastric-cancer-patients-from-northern-brazil
#18
Carolina Rosal Teixeira de Souza, Kátia Soares de Oliveira, Jefferson José Sodré Ferraz, Mariana Ferreira Leal, Danielle Queiroz Calcagno, Aline Damasceno Seabra, André Salim Khayat, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Paulo Pimentel Assumpção, Marília Cardoso Smith, Rommel Rodríguez Burbano
BACKGROUND: Helicobacter pylori (HP) and Epstein-Barr virus (EBV) have been associated with cancer development. We evaluated the prevalence of HP, HP CagA+ and EBV infection in gastric cancer (GC) samples from adults and in gastric tissues from patients who underwent upper endoscopy (UE). METHODS: Samples from UE and GC were collected to investigate the presence of HP infection and the HP virulence factor CagA by a urease test and PCR. The presence of EBV was detected by Eber-1 in situ hybridization...
2014: BMC Gastroenterology
https://www.readbyqxmd.com/read/25232232/follow-up-after-gastrectomy-for-cancer-results-of-an-international-web-round-table
#19
Gian Luca Baiocchi, Yasuhiro Kodera, Daniele Marrelli, Fabio Pacelli, Paolo Morgagni, Franco Roviello, Giovanni De Manzoni
Oncological follow-up after radical gastrectomy for cancer still represents a discrepancy in the field, with many retrospective series demonstrating that early diagnosis of recurrence does not result in an improvement in patient survival; yet, many centers with high quality of care still provide routine patient follow-up after surgery by clinical and instrumental controls. This was the topic for a web round table entitled "Rationale and limits of oncological follow-up after gastrectomy for cancer" that was launched one year before the 10(th) International Gastric Cancer Congress...
September 14, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25180051/genetic-screening-analysis-of-patients-with-hereditary-diffuse-gastric-cancer-from-northern-and-northeastern-brazil
#20
Caroline Aquino Moreira-Nunes, Mariceli Baia Leão Barros, Bárbara do Nascimento Borges, Raquel Carvalho Montenegro, Leticia Martins Lamarão, Helem Ferreira Ribeiro, Amanda Braga Bona, Paulo Pimentel Assumpção, Juan Antonio Rey, Giovanny Rebouças Pinto, Rommel Rodriguez Burbano
BACKGROUND: Hereditary diffuse gastric cancer (HDGC) is a hereditary autosomal inherited syndrome associated with CDH1 germline mutations. In Brazil, gastrointestinal tumors are among the most prevalent tumor types and constitute a serious public health problem, especially in the northern and northeastern regions. This study aimed to investigate germline mutations, methylation pattern and genomic rearrangements in the CDH1 gene and quantitative changes in the DNA of HDGC patients in northern and northeastern Brazil...
2014: Hereditary Cancer in Clinical Practice
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