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Li Qi, Zhong Lu, Yong-Hong Sun, Hai-Tao Song, Wei-Kang Xu
Prostate carcinoma is a devastating disease which is characterized by insidious early symptoms, rapid progression and a poor prognosis. Tripartite motif-containing protein 16 (TRIM16) was identified as an estrogen- and antiestrogen-regulated gene in epithelial cells stably expressing estrogen receptors. The protein encoded by this gene contains two B-box domains and a coiled-coiled region that are characteristic of the B-box zinc finger protein family. Proteins belonging to this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis...
October 17, 2016: International Journal of Molecular Medicine
Sofia Jerez, Andre J van Wijnen, Mario Galindo
Osteosarcoma is an aggressive bone tumor affecting childhood. Currently there are a few proteomic studies analyzing secreted proteins in osteosarcoma. To characterize the osteosarcoma secretome, secreted proteins in the conditioned media of three human osteosarcoma cell lines were analyzed. Exosomes and exosome-free supernatants containing soluble proteins were isolated and characterized. Exosomes were analyzed by transmission electron microscopy (TEM) and western blot. Exosomal and soluble proteins (under 70-100 kDa, respectively) were identified by mass spectrometry analysis using nanoLC-MS/MS...
June 30, 2016: Journal of Cellular Biochemistry
Marta Domínguez, Susana Alvarez, Angel R de Lera
Retinoid X receptors (RXRs) are promiscuous partners of heterodimeric associations with other members of the Nuclear Receptor (NR) superfamily. Through these liaisons RXR ligands ("rexinoids") either transcriptionally activate on their own the "permissive" subclass of heterodimers (PPAR/RXR, LXR/RXR, FXR/RXR) or synergize with partner ligands in the "non-permissive" subclass of heterodimers (RAR/RXR, VDR/RXR and TR/RXR). The nature and extent of the interaction of the ligand-receptor complexes with co-regulators, which is cell and context-dependent, results ultimately in transcriptional modulation of cognate gene networks...
June 16, 2016: Current Topics in Medicinal Chemistry
Kaustubh Adhikari, Macarena Fuentes-Guajardo, Mirsha Quinto-Sánchez, Javier Mendoza-Revilla, Juan Camilo Chacón-Duque, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Michael Cheeseman, Javier Rosique, Gabriel Bedoya, Francisco Rothhammer, Denis Headon, Rolando González-José, David Balding, Andrés Ruiz-Linares
We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10(-8)) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of ∼3,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position...
2016: Nature Communications
Viviane Forsberg, Renyun Zhang, Joakim Bäckström, Christina Dahlström, Britta Andres, Magnus Norgren, Mattias Andersson, Magnus Hummelgård, Håkan Olin
Many solution processing methods of exfoliation of layered materials have been studied during the last few years; most of them are based on organic solvents or rely on surfactants and other funtionalization agents. Pure water should be an ideal solvent, however, it is generally believed, based on solubility theories that stable dispersions of water could not be achieved and systematic studies are lacking. Here we describe the use of water as a solvent and the stabilization process involved therein. We introduce an exfoliation method of molybdenum disulfide (MoS2) in pure water at high concentration (i...
2016: PloS One
Zhang Xiao, Jia Guifang
N(6)-methyladenosine (m(6)A) is one of the most prevalent internal modifications in eukaryotic messenger RNA. The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransferase-like protein 3), METTL14 (Methyltransferase-like protein 14) and WTAP (Wilms tumor 1-associating protein), and erased by two independent demethylases, FTO (Fat mass and obesity associated protein) and ALKBH5 (AlkB homolog 5), in an α-ketoglutarate (α-KG)- and Fe(II)-dependent manner...
April 2016: Yi Chuan, Hereditas
Bárbara L Riestra-Candelaria, Wilma Rodríguez-Mojica, Luis E Vázquez-Quiñones, Juan Carlos Jorge
The liver is one of the principal organs of our body involved in over 500 physiological functions related to metabolism, digestion, immunity, and storage of nutrients, which makes it an essential organ to preserve life. Given that there are a number of approaches to measure liver length through diagnostic 2D sonography, this work aims to determine the most accurate measurement of this organ. Cadaveric specimens (n = 21) were employed to assess measurements in midclavicular line (MCL) and midaxillary line (MAL)...
January 2016: Journal of Diagnostic Medical Sonography: JDMS
Sachin Handa, Martin P Andersson, Fabrice Gallou, John Reilly, Bruce H Lipshutz
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state-of-the-art ligands and catalysts are discussed herein.
April 11, 2016: Angewandte Chemie
Manuela Mihailiasa, Fabrizio Caldera, Jiemeng Li, Roberta Peila, Ada Ferri, Francesco Trotta
Biofunctional textiles are a new category of advanced materials which combine conventional textiles with advanced drug delivery systems to obtain fabrics able to release active principles through skin. The work presents the synthesis of hyper cross-linked β-cyclodextrins nanosponges with the carbonyl group acting as bridge between cyclodextrin molecules. The result of the synthesis is a 3-D porous structure, where melatonin molecules have been complexed. The complex has been characterized by elemental analysis, DSC, SEM, XRD and FT-IR spectroscopy and the results confirm that melatonin interacts with the synthesized nanosponge at molecular level...
May 20, 2016: Carbohydrate Polymers
Chung-Ho Lee, Youn-Jeong Kim, Je-Hee Jang, Jin-Woo Park
Nanoscale topographical modification and surface chemistry alteration using bioactive ions are centrally important processes in the current design of the surface of titanium (Ti) bone implants with enhanced bone healing capacity. Macrophages play a central role in the early tissue healing stage and their activity in response to the implant surface is known to affect the subsequent healing outcome. Thus, the positive modulation of macrophage phenotype polarization (i.e. towards the regenerative M2 rather than the inflammatory M1 phenotype) with a modified surface is essential for the osteogenesis funtion of Ti bone implants...
February 26, 2016: Nanotechnology
Chundong Wang, Yan-Sheng Li, Jianjun Jiang, Wei-Hung Chiang
An effective, large-scale synthesis strategy for producing graphene nanoribbons (GNRs) with a nearly 100% yield has been proposed using a stepwise, solution-based, lengthwise unzipping carbon nanotube (CNT) method. Detailed Raman and X-ray photoelectron spectroscopy (XPS) analysis suggest that GNRs with tunable density of oxygen-containing functional groups on the GNR surfaces can be synthesized by adjusting the oxidant concentration during the CNT unzipping. The electrochemical characterization reveals that the as-produced GNRs with 42...
August 12, 2015: ACS Applied Materials & Interfaces
Yue-Xin Wang, Jing-Jing Sun, Mei Zhang, Xiao-Hua Hou, Jun Hong, Ya-Jing Zhou, Zhi-Yong Zhang
The repair effects of bone marrow mesenchymal stem cell transplantation on nervous system damage are not satisfactory. Propofol has been shown to protect against spinal cord injury. Therefore, this study sought to explore the therapeutic effects of their combination on spinal cord injury. Rat models of spinal cord injury were established using the weight drop method. Rats were subjected to bone marrow mesenchymal stem cell transplantation via tail vein injection and/or propofol injection via tail vein using an infusion pump...
April 2015: Neural Regeneration Research
Yanjuan Tang, Shaolian Zhang, Qingqing Wen, Hongxing Huang, Peihui Yang
A sensitive electrochemiluminescence (ECL) strategy for evaluating the epidermal growth factor receptor (EGFR) expression level on cell surfaces was designed by integrating the specific recognition of EGFR expressed on MCF-7 cell surfaces with an epidermal growth factor (EGF)-funtionalized CdS quantum dots (CdSQDs)-capped magnetic bead (MB) probe. The high sensitivity of ECL probe of EGF-funtionalized CdSQD-capped-MB was used for competitive recognition with EGFR expressed on cell surfaces with recombinant EGFR protein...
June 30, 2015: Analytica Chimica Acta
Savita Chaudhary, Ahmad Umar, S K Mehta
Selenium nanoparticles present an enhanced genetic actions and possess superior adsorptive capacity due to the interaction between the nanoparticles and NH, C=O, COO- and C-N groups of proteins. This review is focused on the biomedical applications of surafce funtionalized selenium nanoparticles. The engineering of exterior surface of the selenium nanoparticles has further emphasizing on the recent progresses in regulating monolayer structures for competent delivery of drugs and biomolecules. Crucial queries of transport, uptake, and clearance are discussed and illustrated through the prospects of selenium nanoparticles...
October 2014: Journal of Biomedical Nanotechnology
Guilang Zheng, Juanjuan Lyu, Shu Liu, Jinda Huang, Cui Liu, Dan Xiang, Meiyan Xie, Qiyi Zeng
Uncoupling protein 2 (UCP2) regulates the production of mitochondrial reactive oxygen species (ROS) and cellular energy transduction under physiological or pathological conditions. In this study, we aimed to determine whether mitochondrial UCP2 plays a protective role in cardiomyocytes under septic conditions. In order to mimic the septic condition, rat embryonic cardiomyoblast-derived H9C2 cells were cultured in the presence of lipopolysaccharide (LPS) plus peptidoglycan G (PepG) and small interfering RNA (siRNA) against UCP2 (siUCP2) was used to suppress UCP2 expression...
June 2015: International Journal of Molecular Medicine
E Biesinger, A Groth, R Höing, M Hölzl
Tinnitus can be caused or triggered by functional disorders of the cervical spine, temporomandibular joint or any other musculoskeletal structure of the neck or head. This special form of tinnitus is called somatosensory tinnitus and represents a discrete subgroup among the different kinds of tinnitus. Distinctive for this kind of tinnitus are alterations in volume and frequency during movement or the stimulation of certain muscles and joints. This can be evaluated using a structured testing method. To be able to easily perceive tinnitus modulations, the test must be performed in total silence...
April 2015: HNO
Yu Wang, Haifeng Su, Chaofa Xu, Gang Li, Lars Gell, Shuichao Lin, Zichao Tang, Hannu Häkkinen, Nanfeng Zheng
An intermetallic nanocluster containing 44 metal atoms, Au24Ag20(2-SPy)4(PhC≡C)20Cl2, was successfully synthesized and structurally characterized by single-crystal analysis and density funtional theory computations. The 44 metal atoms in the cluster are arranged as a concentric three-shell Au12@Ag20@Au12 Keplerate structure having a high symmetry. For the first time, the co-presence of three different types of anionic ligands (i.e., phenylalkynyl, 2-pyridylthiolate, and chloride) was revealed on the surface of metal nanoclusters...
April 8, 2015: Journal of the American Chemical Society
Giuseppe Fatati
Artificial nutrition (AN) is a relatively new medical treatment which started in the 1960 with parenteral nutrition (PN) and over the last 20 years has come to include enteral nutrition (EN) in hospitals and homes. Enormous clinical progress and continual evolution in techniques aimed at rendering organ funtion substitution more complete and efficient have come to the point where AN can only be suitably performed (indications for therapy, treatment regimen and monitoring) in specialized institutions. However, there has been much discussion about whether artificial nutrition should be considered a medical intervention or an essential intervention of care: in 2004 the Terri Schiavo case became worldwide news and the suspension of AN was decided by the law courts...
February 2015: Recenti Progressi in Medicina
Byungjin Cho, Ah Ra Kim, Youngjin Park, Jongwon Yoon, Young-Joo Lee, Sangchul Lee, Tae Jin Yoo, Chang Goo Kang, Byoung Hun Lee, Heung Cho Ko, Dong-Ho Kim, Myung Gwan Hahm
Two-dimensional (2D) molybdenum disulfide (MoS2) atomic layers have a strong potential to be adopted for 2D electronic components due to extraordinary and novel properties not available in their bulk foams. Unique properties of the MoS2, including quasi-2D crystallinity, ultrahigh surface-to-volume, and a high absorption coefficient, have enabled high-performance sensor applications. However, implementation of only a single-functional sensor presents a limitation for various advanced multifunctional sensor applications within a single device...
February 4, 2015: ACS Applied Materials & Interfaces
Haiyun Ma, Li Xue
In tissue engineering, porous nanocomposite scaffolds can potentially mimic aspects of the nanoscale architecture of the extra-cellular matrix, as well as enhance the mechanical properties required for successful weight-bearing implants. In this paper, we demonstrate that highly porous thermoplastic poly(L-lactide) nanocomposite scaffolds containing different types of functionalized multi-walled carbon nanotubes (CNTs). The nanocomposite scaffolds were manufactured by a thermally induced phase separation method...
January 16, 2015: Nanotechnology
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