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https://www.readbyqxmd.com/read/28057648/in-vitro-experiment-to-elucidate-the-mechanism-of-the-soft-shell-technique-for-preventing-subretinal-migration-of-perfluoro-octane
#1
Yau Kei Chan, Yongjie Lu, Gabriela Czanner, Jing Wu, Ho Ching Cheng, Rumana Hussain, Taiji Sakamoto, Ho Cheung Shum, David Wong
AIM: Perfluorocarbon liquid (PFCL) can migrate into subretinal space in detached and stiffened retina with open holes during vitreoretinal surgery. An innovative 'soft shell' technique was introduced to reduce the complication using hyaluronate (HA) to 'cover' the retinal hole. This study aims to study the effectiveness of this technique in vitro. METHODS: Ex vivo porcine retina was mounted on a transwell insert. Beneath the retina was an aqueous solution. Two retinal holes were made using needle punctures...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28043993/safety-and-reproducibility-of-virtual-assisted-lung-mapping-a-multicentre-study-in-japan%C3%A2
#2
Masaaki Sato, Taiji Kuwata, Keiji Yamanashi, Atsushi Kitamura, Kenji Misawa, Kota Imashimizu, Masashi Kobayashi, Masaki Ikeda, Terumoto Koike, Shinji Kosaka, Ryuta Fukai, Yasuo Sekine, Noritaka Isowa, Shin Hirayama, Hiroaki Sakai, Fumiaki Watanabe, Kazuhiro Nagayama, Akihiro Aoyama, Hiroshi Date, Jun Nakajima
OBJECTIVES: Virtual-assisted lung mapping (VAL-MAP) is a preoperative bronchoscopic multispot dye-marking technique using virtual images. The purpose of this study was to evaluate the safety, efficacy and reproducibility of VAL-MAP among multiple centres. METHODS: Selection criteria included patients with pulmonary lesions anticipated to be difficult to identify at thoracoscopy and/or those undergoing sub-lobar lung resections requiring careful determination of resection margins...
January 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28043792/generation-of-a-novel-artificial-trkb-agonist-bm17d99-using-t7-phage-displayed-random-peptide-libraries
#3
Toshiyuki Ohnishi, Kotaro Sakamoto, Asano Asami-Odaka, Kimie Nakamura, Ayako Shimizu, Takashi Ito, Taiji Asami, Tetsuya Ohtaki, Hiroshi Inooka
Tropomyosin receptor kinase B (TrkB) is a known receptor of brain-derived neurotrophic factor (BDNF). Because it plays a critical role in the regulation of neuronal development, maturation, survival, etc., TrkB is a good target for drugs against central nervous system diseases. In this study, we aimed to generate peptidic TrkB agonists by applying random peptide phage display technology. After the phage panning against recombinant Fc-fused TrkB (TrkB-Fc), agonistic phages were directly screened against TrkB-expressing HEK293 cells...
December 30, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28039053/novel-dock2-selective-inhibitory-peptide-that-suppresses-b-cell-line-migration
#4
Kotaro Sakamoto, Yusuke Adachi, Yusaku Komoike, Yusuke Kamada, Ryokichi Koyama, Yasunori Fukuda, Akito Kadotani, Taiji Asami, Jun-Ichi Sakamoto
Dedicator of cytokinesis 2 (DOCK2) is a key molecule for lymphocyte activation and migration. DOCK2 interacts with Ras-related C3 botulinus toxin substrate 1 (Rac1, GTPase) and mediates the GDP-GTP exchange reaction, indicating that inhibitors against protein-protein interaction (PPI) between DOCK2 and Rac1 would be good drug candidates for treating immune-related disorders. Here, we report DOCK2-selective PPI inhibitory peptides discovered using random peptide T7 phage display technology. These peptides inhibited DOCK2 activity at nanomolar concentrations and were delivered to intracellular compartments by combination with cell-penetrating peptide (CPP)...
December 27, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28026168/synthetic-models-of-quasi-stable-amyloid-%C3%AE-40-oligomers-with-significant-neurotoxicity
#5
Yumi Irie, Kazuma Murakami, Mizuho Hanaki, Yusuke Hanaki, Takashi Suzuki, Yoko Monobe, Tomoyo Takai, Ken-Ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie
The formation of soluble oligomers of amyloid β42 and 40 (Aβ42, Aβ40) is the initial event in the pathogenesis of Alzheimer's disease (AD). Based on previous systematic proline replacement and solid-state NMR, we proposed a toxic dimer structure of Aβ42, a highly aggregative alloform, with a turn at positions 22 and 23, and a hydrophobic core in the C-terminal region. However, in addition to Aβ42, Aβ40 dimers can also contribute to AD progression because of the more abundance of Aβ40 monomer in biological fluids...
January 12, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28005721/permeability-and-anti-vascular-endothelial-growth-factor-effects-of-bevacizumab-ranibizumab-and-aflibercept-in-polarized-retinal-pigment-epithelial-layer-in-vitro
#6
Naoya Yoshihara, Hiroto Terasaki, Makoto Shirasawa, Hiroki Kawano, Shozo Sonoda, Munekazu Yamaguchi, Teruto Hashiguchi, Toshio Hisatomi, Tatsuro Ishibashi, Taiji Sakamoto
PURPOSE: To determine the effects of bevacizumab, ranibizumab, and aflibercept on the permeability and the effects of anti-vascular endothelial growth factor (VEGF) on highly polarized retinal pigment epithelial cells (RPECs) in vitro. METHODS: Highly polarized RPECs were cultured in the upper chamber of a Transwell system. Anti-VEGF antibodies were added to the upper chamber, and the concentrations of the drugs in the lower chambers were measured. The permeability rates of the three anti-VEGF drugs through the RPEC layer and the concentration of VEGF in each chamber were determined...
January 2017: Retina
https://www.readbyqxmd.com/read/27991901/distinct-neural-mechanisms-for-the-control-of-thirst-and-salt-appetite-in-the-subfornical-organ
#7
Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda
Body fluid conditions are continuously monitored in the brain to regulate thirst and salt-appetite sensations. Angiotensin II drives both thirst and salt appetite; however, the neural mechanisms underlying selective water- and/or salt-intake behaviors remain unknown. Using optogenetics, we show that thirst and salt appetite are driven by distinct groups of angiotensin II receptor type 1a-positive excitatory neurons in the subfornical organ. Neurons projecting to the organum vasculosum lamina terminalis control water intake, while those projecting to the ventral part of the bed nucleus of the stria terminalis control salt intake...
December 19, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27977842/optical-coherence-tomography-angiography-for-detecting-choroidal-neovascularization-secondary-to-punctate-inner-choroidopathy
#8
Shintaro Nakao, Yoshihiro Kaizu, Yuji Oshima, Taiji Sakamoto, Tatsuro Ishibashi, Koh-Hei Sonoda
Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27974321/changes-of-choroidal-structure-after-intravitreal-aflibercept-therapy-for-polypoidal-choroidal-vasculopathy
#9
Erina Daizumoto, Yoshinori Mitamura, Hiroki Sano, Kei Akaiwa, Masanori Niki, Chihiro Yamanaka, Takamasa Kinoshita, Mariko Egawa, Shozo Sonoda, Taiji Sakamoto
AIMS: To quantify the changes of the choroidal structure in the enhanced depth imaging optical coherence tomographic (EDI-OCT) images after intravitreal aflibercept (IVA) injections for polypoidal choroidal vasculopathy (PCV). METHODS: Retrospective, observational case series. Forty eyes of 40 treatment-naive patients who underwent IVA for PCV were examined by EDI-OCT before, and 3 months and 12 months after IVA. The EDI-OCT images were binarised by ImageJ software...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27973598/effects-of-exercise-on-the-structure-and-circulation-of-choroid-in-normal-eyes
#10
Takamasa Kinoshita, Junya Mori, Natsuki Okuda, Hiroko Imaizumi, Masanori Iwasaki, Miho Shimizu, Hirotomo Miyamoto, Kei Akaiwa, Kentaro Semba, Shozo Sonoda, Taiji Sakamoto, Yoshinori Mitamura
AIMS: To determine the effects of dynamic exercise on the circulation and the luminal and stromal areas of the choroid in normal eyes. METHODS: This was a prospective interventional study of 38 eyes of 38 normal subjects enrolled by invitation. The systolic and diastolic blood pressures, heart rate, intraocularpressure, mean ocular perfusion pressure (MOPP), choroidal blood velocity, and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded before, and immediately after mild dynamic exercise...
2016: PloS One
https://www.readbyqxmd.com/read/27941025/a-novel-rac1-gspt1-signaling-pathway-controls-astrogliosis-following-central-nervous-system-injury
#11
Taiji Ishii, Takehiko Ueyama, Michiko Shigyo, Masaaki Kohta, Takeshi Kondoh, Tomoharu Kuboyama, Tatsuya Uebi, Takeshi Hamada, David H Gutmann, Atsu Aiba, Eiji Kohmura, Chihiro Tohda, Naoaki Saito
Astrogliosis (i.e., glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury. In an effort to identify potential molecules/pathways that regulate astrogliosis, we sought to determine whether Rac/Rac-mediated signaling in astrocytes represents a novel candidate for therapeutic intervention following CNS injury. For these studies, we generated Rac1-knockout (KO) mice under the control of the glial fibrillary acidic protein (GFAP) promoter (GFAP-Cre;Rac1(flox/flox))...
December 9, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27932476/high-fat-diet-induced-lysosomal-dysfunction-and-impaired-autophagic-flux-contribute-to-lipotoxicity-in-the-kidney
#12
Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomonori Kimura, Tomoko Namba, Jun Matsuda, Satoshi Minami, Jun-Ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Yoshitaka Isaka
Excessive fat intake contributes to the progression of metabolic diseases via cellular injury and inflammation, a process termed lipotoxicity. Here, we investigated the role of lysosomal dysfunction and impaired autophagic flux in the pathogenesis of lipotoxicity in the kidney. In mice, a high-fat diet (HFD) resulted in an accumulation of phospholipids in enlarged lysosomes within kidney proximal tubular cells (PTCs). In isolated PTCs treated with palmitic acid, autophagic degradation activity progressively stagnated in association with impaired lysosomal acidification and excessive lipid accumulation...
December 8, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27900535/evaluation-of-cerebral-circulation-during-retrograde-perfusion-by-laser-speckle-flowgraphy
#13
Fumiaki Kimura, Hirotsugu Kanda, Yuki Toyama, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroto Kitahara, Hiroyuki Kamiya
Laser speckle flowgraphy (LSFG) is an ophthalmologic equipment that qualitatively detects the blood flow of the optic nerve head, which is known to be related with cerebral microcirculation. LSFG can also measure the mean blur rate, which quantitatively calculates the blood flow. We aimed to assess the utility of LSFG in the evaluation of cerebral perfusion during aortic surgery under hypothermic circulatory arrest with retrograde and antegrade cerebral perfusion. Two patients underwent total arch replacement for aneurysm...
November 29, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27898984/transforming-growth-factor-%C3%AE-signaling-cascade-induced-by-mechanical-stimulation-of-fluid-shear-stress-in-cultured-corneal-epithelial-cells
#14
Tsugiaki Utsunomiya, Akihiro Ishibazawa, Taiji Nagaoka, Kazuomi Hanada, Harumasa Yokota, Nobuhito Ishii, Akitoshi Yoshida
Purpose: Because blinking is regarded as mechanical stimulation of fluid shear stress on the corneal epithelial cells, we investigated the effects of fluid shear stress on cultured human corneal epithelial cells (HCECs). Methods: The HCECs were exposed to shear stress (0, 1.2, 12 dyne/cm2) with the parallel-plate type of flow chamber. Wound healing, cellular proliferation, growth factor expression, TGF-β1 concentration in the culture supernatant, and phosphorylation of SMAD2 were investigated...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27890552/combined-use-of-intra-aortic-balloon-pump-and-venoarterial-extracorporeal-membrane-oxygenation-support-with-femoral-arterial-cannulation-impairs-cerebral-microcirculation-evaluation-with-laser-speckle-flowgraphy
#15
Hirotsugu Kanda, Fumiaki Kimura, Takafumi Iida, Megumi Kanao-Kanda, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroyuki Kamiya
No abstract text is available yet for this article.
September 15, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27885191/-modeling-and-simulation-of-trabecular-pattern-formation-in-a-cancellous-bone-defect-under-mechanical-forces
#16
Taiji Adachi
Understanding regeneration of the trabecular structure in cancellous bone defects is an important issue in bone tissue engineering and regenerative medicine. Biochemical and biomechanical viewpoints are indispensable for understanding the fundamental mechanism that underlies the regeneration of the trabecular structure. In vitro observations of the Turing pattern-like bone differentiation into osteoblasts from human mesenchymal stem cells suggest that mathematical modeling and simulation based on a reaction-diffusion system model would help us to understand the mechanism of trabecular pattern formation during cancellous bone regeneration...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27873064/development-of-diffuse-large-b-cell-lymphoma-from-follicular-lymphoma-of-the-duodenum-changes-in-endoscopic-findings-during-a-6-year-follow-up
#17
Hiroyuki Kitabatake, Tadanobu Nagaya, Naoki Tanaka, Hiroyoshi Ota, Kenji Sano, Naoko Asano, Tomoaki Suga, Yoshiyuki Nakamura, Taiji Akamatsu, Eiji Tanaka
A 71-year-old Japanese man was diagnosed as having stage I primary follicular lymphoma (FL) of the duodenum according to Lugano International Conference Classification and began receiving annual checkups. Endoscopic examination disclosed white villi swelling with depressed red mucosal lesions. Biopsy specimens from the area of white villi exhibited histopathological features that met the diagnostic criteria for low-grade FL. The depressed red lesions gradually enlarged over six years of follow-up. A biopsy of the white villi swelling revealed distinct well-circumscribed follicles with attenuated mantles in the lamina propria that were positive for CD20, bcl-2, and CD10...
November 21, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27857062/identification-of-an-orally-active-small-molecule-pthr1-agonist-for-the-treatment-of-hypoparathyroidism
#18
Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato, Yoshiki Kawabe
Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we show that PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27849310/characteristics-of-retinal-neovascularization-in-proliferative-diabetic-retinopathy-imaged-by-optical-coherence-tomography-angiography
#19
Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Atsushi Takahashi, Tsuneaki Omae, Young-Seok Song, Tatsuhisa Takahashi, Akitoshi Yoshida
Purpose: To characterize the morphology of neovascularization at the disc (NVD) and neovascularization elsewhere (NVE) in treatment-naïve or previously treated proliferative diabetic retinopathy (PDR) patients using optical coherence tomography (OCT) angiography. Methods: En face OCT angiograms of NVD/NVE in 40 eyes of 33 patients with PDR were acquired using RTVue XR Avanti OCT. The morphology of NVD/NVE on OCT angiograms was evaluated, and the activity was determined by biomicroscopy and fluorescein angiography (FA)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27847081/complete-resection-of-thymic-sarcomatoid-carcinoma-through-total-aortic-arch-replacement
#20
Soichi Oka, Akihiro Taira, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Hidetaka Uramoto, Yosuke Nishimura, Fumihiro Tanaka
Sarcomatoid carcinoma of the thymus is extremely rare. An operation remains the only effective treatment for this disease. We report a case of complete resection of thymic sarcomatoid carcinoma through a total aortic arch replacement and left upper lobectomy at our institution. Our aggressive operation was very effective, and the patient has experienced no recurrence in the 3 years since his operation.
December 2016: Annals of Thoracic Surgery
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