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https://www.readbyqxmd.com/read/27900535/evaluation-of-cerebral-circulation-during-retrograde-perfusion-by-laser-speckle-flowgraphy
#1
Fumiaki Kimura, Hirotsugu Kanda, Yuki Toyama, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroto Kitahara, Hiroyuki Kamiya
Laser speckle flowgraphy (LSFG) is an ophthalmologic equipment that qualitatively detects the blood flow of the optic nerve head, which is known to be related with cerebral microcirculation. LSFG can also measure the mean blur rate, which quantitatively calculates the blood flow. We aimed to assess the utility of LSFG in the evaluation of cerebral perfusion during aortic surgery under hypothermic circulatory arrest with retrograde and antegrade cerebral perfusion. Two patients underwent total arch replacement for aneurysm...
November 29, 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27898984/transforming-growth-factor-%C3%AE-signaling-cascade-induced-by-mechanical-stimulation-of-fluid-shear-stress-in-cultured-corneal-epithelial-cells
#2
Tsugiaki Utsunomiya, Akihiro Ishibazawa, Taiji Nagaoka, Kazuomi Hanada, Harumasa Yokota, Nobuhito Ishii, Akitoshi Yoshida
Purpose: Because blinking is regarded as mechanical stimulation of fluid shear stress on the corneal epithelial cells, we investigated the effects of fluid shear stress on cultured human corneal epithelial cells (HCECs). Methods: The HCECs were exposed to shear stress (0, 1.2, 12 dyne/cm2) with the parallel-plate type of flow chamber. Wound healing, cellular proliferation, growth factor expression, TGF-β1 concentration in the culture supernatant, and phosphorylation of SMAD2 were investigated...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27890552/combined-use-of-intra-aortic-balloon-pump-and-venoarterial-extracorporeal-membrane-oxygenation-support-with-femoral-arterial-cannulation-impairs-cerebral-microcirculation-evaluation-with-laser-speckle-flowgraphy
#3
Hirotsugu Kanda, Fumiaki Kimura, Takafumi Iida, Megumi Kanao-Kanda, Takayuki Kunisawa, Taiji Nagaoka, Akitoshi Yoshida, Hiroyuki Kamiya
No abstract text is available yet for this article.
September 15, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27885191/-modeling-and-simulation-of-trabecular-pattern-formation-in-a-cancellous-bone-defect-under-mechanical-forces
#4
Taiji Adachi
Understanding regeneration of the trabecular structure in cancellous bone defects is an important issue in bone tissue engineering and regenerative medicine. Biochemical and biomechanical viewpoints are indispensable for understanding the fundamental mechanism that underlies the regeneration of the trabecular structure. In vitro observations of the Turing pattern-like bone differentiation into osteoblasts from human mesenchymal stem cells suggest that mathematical modeling and simulation based on a reaction-diffusion system model would help us to understand the mechanism of trabecular pattern formation during cancellous bone regeneration...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27873064/development-of-diffuse-large-b-cell-lymphoma-from-follicular-lymphoma-of-the-duodenum-changes-in-endoscopic-findings-during-a-6-year-follow-up
#5
Hiroyuki Kitabatake, Tadanobu Nagaya, Naoki Tanaka, Hiroyoshi Ota, Kenji Sano, Naoko Asano, Tomoaki Suga, Yoshiyuki Nakamura, Taiji Akamatsu, Eiji Tanaka
A 71-year-old Japanese man was diagnosed as having stage I primary follicular lymphoma (FL) of the duodenum according to Lugano International Conference Classification and began receiving annual checkups. Endoscopic examination disclosed white villi swelling with depressed red mucosal lesions. Biopsy specimens from the area of white villi exhibited histopathological features that met the diagnostic criteria for low-grade FL. The depressed red lesions gradually enlarged over six years of follow-up. A biopsy of the white villi swelling revealed distinct well-circumscribed follicles with attenuated mantles in the lamina propria that were positive for CD20, bcl-2, and CD10...
November 21, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27857062/identification-of-an-orally-active-small-molecule-pthr1-agonist-for-the-treatment-of-hypoparathyroidism
#6
Tatsuya Tamura, Hiroshi Noda, Eri Joyashiki, Maiko Hoshino, Tomoyuki Watanabe, Masahiko Kinosaki, Yoshikazu Nishimura, Tohru Esaki, Kotaro Ogawa, Taiji Miyake, Shinichi Arai, Masaru Shimizu, Hidetomo Kitamura, Haruhiko Sato, Yoshiki Kawabe
Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we show that PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27849310/characteristics-of-retinal-neovascularization-in-proliferative-diabetic-retinopathy-imaged-by-optical-coherence-tomography-angiography
#7
Akihiro Ishibazawa, Taiji Nagaoka, Harumasa Yokota, Atsushi Takahashi, Tsuneaki Omae, Young-Seok Song, Tatsuhisa Takahashi, Akitoshi Yoshida
Purpose: To characterize the morphology of neovascularization at the disc (NVD) and neovascularization elsewhere (NVE) in treatment-naïve or previously treated proliferative diabetic retinopathy (PDR) patients using optical coherence tomography (OCT) angiography. Methods: En face OCT angiograms of NVD/NVE in 40 eyes of 33 patients with PDR were acquired using RTVue XR Avanti OCT. The morphology of NVD/NVE on OCT angiograms was evaluated, and the activity was determined by biomicroscopy and fluorescein angiography (FA)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27847081/complete-resection-of-thymic-sarcomatoid-carcinoma-through-total-aortic-arch-replacement
#8
Soichi Oka, Akihiro Taira, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Hidetaka Uramoto, Yosuke Nishimura, Fumihiro Tanaka
Sarcomatoid carcinoma of the thymus is extremely rare. An operation remains the only effective treatment for this disease. We report a case of complete resection of thymic sarcomatoid carcinoma through a total aortic arch replacement and left upper lobectomy at our institution. Our aggressive operation was very effective, and the patient has experienced no recurrence in the 3 years since his operation.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27837328/in-total-hip-arthroplasty-via-the-direct-anterior-approach-a-dual-mobility-cup-prevents-dislocation-as-effectively-in-hip-fracture-as-in-osteoarthritis
#9
Yasuhiro Homma, Tomonori Baba, Yu Ozaki, Taiji Watari, Hideo Kobayashi, Hironori Ochi, Mikio Matsumoto, Kazuo Kaneko
PURPOSE: The main purpose of this study was to compare the outcome of total hip arthroplasty (THA) via the direct anterior approach (DAA) using a dual-mobility cup (DMC) in patients with femoral neck fracture to those in patients undergoing elective THA for osteoarthritis. PATIENTS AND METHODS: We retrospectively investigated 40 hips with femoral neck fracture (group A), and 81 hips with osteoarthritis (group B). THA via the DAA using the DMC was performed in both groups...
November 11, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27829627/a-perturbation-analysis-to-understand-the-mechanism-how-migrating-cells-sense-and-respond-to-a-topography-in-the-extracellular-environment
#10
Hiromi Miyoshi, Kensuke Suzuki, Jungmyoung Ju, Jong Soo Ko, Taiji Adachi, Yutaka Yamagata
Migrating cells in vivo monitor the physiological state of an organism by integrating the physical as well as chemical cues in the extracellular microenvironment, and alter the migration mode, in order to achieve their unique function. The clarification of the mechanism focusing on the topographical cues is important for basic biological research, and for biomedical engineering specifically to establish the design concept of tissue engineering scaffolds. The aim of this study is to understand how cells sense and respond to the complex topographical cues in vivo by exploring in vitro analyses to complex in vivo situations in order to simplify the issue...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27829538/pharmacokinetic-drug-interaction-study-between-overactive-bladder-drugs-mirabegron-and-tolterodine-in-japanese-healthy-postmenopausal-females
#11
Yuki Nomura, Hiromi Iitsuka, Junko Toyoshima, Kentaro Kuroishi, Toshifumi Hatta, Atsunori Kaibara, Masataka Katashima, Selina Moy, Taiji Sawamoto
Mirabegron, the first selective β3-adrenoceptor agonist for the treatment of overactive bladder (OAB), inhibits cytochrome P450 isozyme CYP2D6. This study was performed in Japanese healthy postmenopausal female volunteers to assess any pharmacokinetic drug interaction between mirabegron and tolterodine, another OAB drug and a sensitive substrate of CYP2D6. Tolterodine 4 mg was orally administered from Days 1-7 and co-administered with mirabegron 50 mg from Days 8-14. Mirabegron 50 mg increased maximum concentration (Cmax) and area under the concentration-time curve from zero to 24 h after dosing (AUC24h) of tolterodine by 2...
August 18, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27828909/incomplete-repair-of-retinal-structure-after-vitrectomy-with-internal-limiting-membrane-peeling
#12
Toshio Hisatomi, Takashi Tachibana, Shoji Notomi, Shunji Nakatake, Kohta Fujiwara, Yusuke Murakami, Yasuhiro Ikeda, Shigeo Yoshida, Hiroshi Enaida, Toshinori Murata, Taiji Sakamoto, Koh-Hei Sonoda, Tatsuro Ishibashi
PURPOSE: To examine retinal changes after vitrectomy with internal limiting membrane (ILM) peeling, we used a cynomolgus monkey model and focused on surgical damages of ILM peeling for long observational period of 3 years. METHODS: Vitrectomy was performed followed by ILM peeling similar to clinical settings in humans. Ultrastructural changes of the retina were investigated by light, transmission, and scanning electron microscopy at 3 months and 3 years after ILM peeling...
November 8, 2016: Retina
https://www.readbyqxmd.com/read/27822875/middle-mediastinal-thymic-carcinoma-with-cystic-findings-in-radiologic-images-a-case-report
#13
Shuichi Shinohara, Koji Kuroda, Taiji Kuwata, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Fumihiro Tanaka
BACKGROUND: Thymic carcinomas are usually detected in the anterior mediastinum. Thymic carcinoma occurring in the middle mediastinum and showing an image of a cyst is extremely rare. CASE PRESENTATION: A 64-year-old man with a middle mediastinal tumor detected incidentally by a CT scan was referred. Chest CT showed an entirely cystic mass in the middle mediastinum between the bilateral brachiocephalic vein and trachea. We resected the tumor completely in the right recurrent nerve because it had invaded the nerve...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27818818/total-hip-arthroplasty-for-implant-rupture-after-surgery-for-atypical-subtrochanteric-femoral-fracture
#14
Yu Ozaki, Tomonori Baba, Hironori Ochi, Yasuhiro Homma, Taiji Watari, Mikio Matsumoto, Kazuo Kaneko
Treatment methods for delayed union and nonunion of atypical femoral fracture are still controversial. Moreover, no treatment method has been established for implant rupture caused by delayed union and nonunion. We encountered a 74-year-old female in whom nonunion-induced implant rupture occurred after treatment of atypical subtrochanteric femoral fracture with internal fixation using a long femoral nail. It was unlikely that sufficient fixation could be obtained by repeating osteosynthesis alone. Moreover, the patient was elderly and early weight-bearing activity was essential for early recovery of ADL...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27815610/matrix-assisted-laser-desorption-ionization-imaging-mass-spectrometry-reveals-changes-of-phospholipid-distribution-in-induced-pluripotent-stem-cell-colony-differentiation
#15
Yasuo Shimizu, Motoyasu Satou, Keitaro Hayashi, Yusuke Nakamura, Mio Fujimaki, Yasuhiro Horibata, Hiromi Ando, Taiji Watanabe, Taichi Shiobara, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto, Naohiko Anzai, Yoshiki Ishii
Induced pluripotent stem cells (iPSCs) are opening up new possibilities for medicine. Understanding the regulation of iPSC biology is important when attempting to apply these cells to disease models or therapy. Changes of lipid metabolism in iPSCs were investigated by matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry (MALDI-TOF-IMS). Analysis revealed changes of the intensity and distribution of peaks at m/z 782.5 and 798.5 in iPSC colonies during spontaneous differentiation...
November 4, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27790371/total-or-partial-vertebrectomy-for-lung-cancer-invading-the-spine
#16
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Sohsuke Yamada, Hidetaka Uramoto, Eiichiro Nakamura, Fumihiro Tanaka
BACKGROUND: Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. However, recent advances in surgical techniques as well as in perioperative care may improve outcomes of lung cancer surgery with vertebrectomy. We describe our surgical approach and assess the outcome lung cancer invading the spine. METHODS: We retrospectively reviewed our recent experiences of lung cancer with vertebral invasion, in which we have performed total or partial vertebrectomy from January 2011 through April 2015...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27790122/achievement-of-cure-with-gefitinib-in-advanced-lung-adenocarcinoma-harboring-an-activating-egfr-mutation-a-case-report
#17
Taiji Kuwata, Kazue Yoneda, Kenichi Kobayashi, Rintarou Oyama, Hiroki Matumiya, Shuichi Shinohara, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) may achieve long-term survival in selected cases with advanced non-small cell lung cancer harboring activating mutations in the EGFR gene, but a cured case has not been reported yet. Here, we present the first case of EGFR-mutated lung adenocarcinoma cured with an EGFR-TKI, as the 75-year-old Japanese man has achieved complete response with gefitinib treatment and has survived without tumor 10 years after termination of gefitinib treatment...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27787450/iris-atrophy-a-novel-sign-of-repeated-self-inflicted-laser-pointer-maculopathy
#18
Rosa Dolz-Marco, Eduardo Cunha Souza, Tomohiro Iida, Carlos A Moreira, Aloysio Nakashima, Taiji Hasegawa, K Bailey Freund
No abstract text is available yet for this article.
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27771988/evaluation-of-protein-ligand-affinity-prediction-using-steered-molecular-dynamics-simulations
#19
Noriaki Okimoto, Atsushi Suenaga, Makoto Taiji
In computational drug design, ranking a series of compound analogues in a manner that is consistent with experimental affinities remains a challenge. In this study, we evaluated the prediction of protein-ligand binding affinities using steered molecular dynamics simulations. First, we investigated the appropriate conditions for accurate predictions in these simulations. A conic harmonic restraint was applied to the system for efficient sampling of work values on the ligand unbinding pathway. We found that pulling velocity significantly influenced affinity predictions, but that the number of collectable trajectories was less influential...
October 24, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27766630/classical-hodgkin-lymphoma-producing-macrophage-colony-stimulating-factor-with-resultant-monocytosis
#20
Uta Nishiwaki, Shoko Nakayama, Taiji Yokote, Nobuya Hiraoka, Motomu Tsuji
No abstract text is available yet for this article.
October 21, 2016: British Journal of Haematology
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