keyword
MENU ▼
Read by QxMD icon Read
search

taiji

keyword
https://www.readbyqxmd.com/read/28626523/antiobesity-effect-of-a-short-length-peptide-yy-analogue-after-continuous-administration-in-mice
#1
Naoki Nishizawa, Ayumu Niida, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Hideki Hirabayashi, Nobuyuki Amano, Tetsuya Ohtaki, Taiji Asami
Gastrointestinal peptides such as peptide YY (PYY) can regulate appetite, which is relevant to the study of obesity. The intraperitoneal bolus administration of PYY3-36 and a 12-amino acid PYY analogue, benzoyl-[Cha(27,28,36),Aib(31)]PYY25-36 (1), showed similar anorectic activity by activating the Y2 receptor (Y2R). However, food intake inhibition and body weight loss were not observed upon continuous subcutaneous administration of 1 with osmotic pumps in diet-induced obese (DIO) mice. N-Terminal elongation of 1, together with amino acid substitution at position 24, led to a hydrophilic 14-amino acid peptide, Ac-[d-Hyp(24),Cha(27,28,36),Aib(31)]PYY23-36 (18), that showed higher affinity and more potent agonist activity for Y2R and a robust anorectic activity with potency similar to that of PYY3-36...
June 8, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28616714/effect-of-fluid-air-exchange-on-reducing-residual-silicone-oil-after-silicone-oil-removal
#2
Hideki Shiihara, Taiji Sakamoto, Hiroto Terasaki, Takehiro Yamashita, Naoya Yoshihara, Fumiki Okamoto, Nahoko Ogata, Toshifumi Yamashita, Shozo Sonoda, Yoshinori Mitamura
PURPOSE: Our purpose was to determine the effect of fluid-air exchange on the amount of silicone oil (SO) droplets remaining in the vitreous cavity after removal of the main body of the SO. METHODS: This was a retrospective comparative study of 56 eyes of 56 patients that had undergone vitrectomy with SO tamponade. Fluid-air exchange was performed during surgery in 30 eyes [Air Ex(+) group] and was not done in 26 eyes [Air Ex(-) group]. All of the eyes were examined by ultrasonography, and the images were converted to binarized image...
June 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28610573/correlation-between-short-and-long-term-effects-of-intravitreal-ranibizumab-therapy-on-macular-edema-after-branch-retinal-vein-occlusion-a-prospective-observational-study
#3
Yoshiro Minami, Taiji Nagaoka, Akihiro Ishibazawa, Akitoshi Yoshida
BACKGROUND: The correlation between the short- and long-term effects of intravitreal ranibizumab (IVR) on macular edema after branch retinal vein occlusion (BRVO) remains unclear. We assessed the correlation between the short- and long-term effects of IVR on macular edema after BRVO. METHODS: Twenty-one eyes with macular edema after BRVO were enrolled in this prospective observational study. We measured the foveal thickness (FT) and the best-corrected visual acuity (BCVA) before, 1 day after, and 1 month after IVR (0...
June 13, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28599475/therapeutic-results-of-a-novel-enzyme-targeting-radiosensitization-treatment-kochi-oxydol-radiation-therapy-for-unresectable-carcinomas-ii-in-patients-with-stage-i-primary-breast-cancer
#4
Nobutaka Aoyama, Yasuhiro Ogawa, Miki Yasuoka, Kenta Ohgi, Hitomi Iwasa, Kana Miyatake, Rika Yoshimatsu, Tomoaki Yamanishi, Norihiko Hamada, Taiji Tamura, Kana Kobayashi, Yoriko Murata, Mitsuhiko Miyamura, Takuji Yamagami
Linac-based stereotactic radiotherapy has little effect on the majority of advanced neoplasms. Therefore, the novel radiosensitizer Kochi oxydol-radiation therapy for unresectable carcinomas (KORTUC) II, which contains hydrogen peroxide and sodium hyaluronate, was developed. The effectiveness of KORTUC II for the treatment of chemotherapy-resistant supraclavicular lymph node metastases, recurrent breast cancer and stage IV primary breast cancer has previously been demonstrated. The present study evaluated the safety and efficacy of KORTUC II for patients with stage I primary breast cancer...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28596054/a-potent-and-selective-natriuretic-peptide-receptor-3-blocker-11-mer-peptide-created-by-hybridization-of-musclin-and-atrial-natriuretic-peptide
#5
Naoki Nishizawa, Goshi Nakamura, Yoko Noguchi, Hideyuki Nakagawa, Ayako Shimizu, Masaharu Nakayama, Shiro Takekawa, Taiji Asami
The natriuretic peptide (NP) system is a critical endocrine, autocrine, and paracrine system and has been investigated for potential use against cardiovascular and metabolic diseases. The clearance of NPs is regulated by the proteolysis of neutral endopeptidase (NEP) and by endocytosis via natriuretic peptide receptor-3 (NPR3). A linear NPR3-selective peptide, [Cha(8)]-ANP(7-16)-NH2 (1), showed potent binding affinity for NPR3 but poor predicted chemical stability due to its free thiol group. A 12-mer peptide (9) without a thiol group was designed by the hybridization of two NPR3-binding peptides: a linear ANP fragment peptide analog and musclin, a murine member of the bHLH family of transcription factors, possessed high binding affinity and strict selectivity for NPR3...
May 20, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28593169/atherosclerosis-is-associated-with-erectile-function-and-lower-urinary-tract-symptoms-especially-nocturia-in-middle-aged-men
#6
Akira Tsujimura, Ippei Hiramatsu, Yusuke Aoki, Hirofumi Shimoyama, Taiki Mizuno, Taiji Nozaki, Masato Shirai, Kazuhiro Kobayashi, Yoshiaki Kumamoto, Shigeo Horie
BACKGROUND: Atherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related to quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent in aging men and are significantly associated with a reduced QOL. However, few questionnaire-based studies have fully examined the relation between atherosclerosis and several urological symptoms. MATERIALS AND METHODS: The study comprised 303 outpatients who visited our clinic with symptoms of LOH...
June 2017: Prostate International
https://www.readbyqxmd.com/read/28589052/safe-and-effective-reduction-technique-for-intertrochanteric-fracture-with-ipsilateral-below-knee-amputated-limb
#7
Hironori Ochi, Tomonori Baba, Takahiro Hamanaka, Yu Ozaki, Taiji Watari, Yasuhiro Homma, Mikio Matsumoto, Kazuo Kaneko
The positioning of the patient on the fracture table is critical for the successful reduction and operative fixation of intertrochanteric hip fractures. However, this manipulation is challenging with patients who have undergone amputations of their legs. A 97-year-old man presented to the emergency department with symptom of right hip pain following a mechanical fall. He had a below-knee amputation on his right leg following a traffic accident as a 19-year-old and had a below-knee patellar tendon bearing prosthesis fitted to his lower limb for mobility...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28571035/serological-evaluation-of-gastric-cancer-risk-based-on-pepsinogen-and-helicobacter-pylori-antibody-relationship-to-endoscopic-findings
#8
Takahiro Kotachi, Masanori Ito, Masaharu Yoshihara, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Taiji Matsuo, Shinji Tanaka, Kazuaki Chayama
BACKGROUNDS AND AIMS: The serological risk-prediction system combined the pepsinogen (PG) test, and anti-Helicobacter pylori antibody is available for evaluation of gastric cancer risk. In this system, chronic atrophic gastritis (CAG) or H. pylori infection is diagnosed. Subjects with H. pylori negative and PG test negative (group A) are supposed to be those who have never been infected with H. pylori and are at extremely low risk for gastric cancer. However, a certain proportion of patients with CAG has been identified as the extremely low-risk group (group A)...
June 2, 2017: Digestion
https://www.readbyqxmd.com/read/28555365/long-term-results-of-rotational-acetabular-osteotomy-for-osteonecrosis-with-collapse-of-the-femoral-head-in-young-patients
#9
Tomonori Baba, Masahiko Nozawa, Yasuhiro Homma, Hironori Ochi, Yu Ozaki, Taiji Watari, Mikio Matsumoto, Kazuo Kaneko
PURPOSE: The surgical treatment of osteonecrosis with collapse of the femoral head is still controversial. The purpose of this study was to investigate the clinical outcome of rotational acetabular osteotomy by Ninomiya and Tagawa for osteonecrosis of the femoral head in young patients. PATIENTS AND METHODS: Rotational acetabular osteotomy was performed in 202 consecutive patients between 1995 and 2003. Among them, rotational acetabular osteotomy with osteonecrosis of the femoral head was performed in 31 patients (42 hips)...
May 29, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28542289/structural-parameters-associated-with-location-of-peaks-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-young-healthy-eyes
#10
Takehiro Yamashita, Ryo Asaoka, Yuya Kii, Hiroto Terasaki, Hiroshi Murata, Taiji Sakamoto
The location of the peaks of the circumpapillary retinal nerve fiber layer (cpRNFL) thickness is affected by several ocular parameters. In this study, we have generated equations that can determine the peaks of the cpRNFL. This study was a prospective, observational, cross sectional study of 118 healthy right eyes. The axial length, optic disc tilt, superiortemporal (ST)- and inferiortemporal (IT)-peaks of the cpRNFL thickness, and angles of the ST and IT retinal arteries (RA) and veins (RV) were determined...
2017: PloS One
https://www.readbyqxmd.com/read/28542153/erratum-distinct-neural-mechanisms-for-the-control-of-thirst-and-salt-appetite-in-the-subfornical-organ
#11
Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi, Masaharu Noda
No abstract text is available yet for this article.
May 25, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28523374/capturing-microscopic-features-of-bone-remodeling-into-a-macroscopic-model-based-on-biological-rationales-of-bone-adaptation
#12
Young Kwan Kim, Yoshitaka Kameo, Sakae Tanaka, Taiji Adachi
To understand Wolff's law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account...
May 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28521331/retinal-deep-capillary-ischemia-associated-with-an-occluded-congenital-retinal-macrovessel
#13
Taiji Hasegawa, Nahoko Ogata
PURPOSE: To report the case of a patient with an occluded congenital retinal macrovessel accompanied by retinal deep capillary ischemia. METHODS: A 38-year-old woman presented with a 2-day history of a paracentral scotoma of her right eye. RESULTS: Fundus photograph showed a dilated congenital retinal macrovessel with arteriovenous anastomosis, an intravascular white region indicating the thrombus at arteriovenous anastomotic region, and an area of retinal whitening temporal to the fovea...
July 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28521269/a-new-technique-for-dorsal-sural-nerve-conduction-study-with-surface-strip-electrodes
#14
Shoji Hemmi, Katsumi Kurokawa, Taiji Nagai, Ryutaro Kushida, Toshio Okamoto, Tatsufumi Murakami, Yoshihide Sunada
OBJECTIVE: To obtain higher amplitude of dorsal sural sensory nerve action potentials (SNAPs), we used a new method for dorsal sural nerve conduction study with surface strip electrodes (SSEs). METHODS: Dorsal sural SNAPs were recorded orthodromically. The recording electrodes were placed behind the lateral malleolus. SSEs were attached to the laterodorsal aspect of the foot for stimulation of the dorsal sural nerve (DSN). We also used a conventional method with a standard bipolar stimulator and compared the findings...
July 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28497709/use-of-proximal-side-hole-micro-balloon-catheter-in-transcatheter-hepatic-arterial-chemoembolization
#15
Takuji Yamagami, Rika Yoshimatsu, Miki Nishimori, Kenta Ogi, Taiji Tamura, Shinji Iwasaki, Tomoaki Yamanishi
We report on a 70-year-old man with unresectable multiple hepatocellular carcinomas who underwent treatment with transcatheter hepatic arterial chemoembolization. In treating a tumor in segment 1 of the liver, the proximal side-hole micro-balloon catheter, which has been newly developed, was useful.
May 12, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28496045/cholic-acid-enhances-visceral-adiposity-atherosclerosis-and-nonalcoholic-fatty-liver-disease-in-microminipigs
#16
Sohsuke Yamada, Hiroaki Kawaguchi, Tomonobu Yamada, Xin Guo, Kei Matsuo, Taiji Hamada, Naoki Miura, Takashi Tasaki, Akihide Tanimoto
AIM: We have recently established a novel swine model for studies of atherosclerosis using Microminipigs(TM) (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries. METHODS: The µMPs were fed HcD supplemented with 0.7% CA (HcD+CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adiposity and lesion formation in the aorta, liver, and other organs was investigated...
May 11, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28492435/clinical-findings-of-eyes-with-macular-edema-associated-with-branch-retinal-vein-occlusion-refractory-to-ranibizumab
#17
Taiji Hasegawa, Taizo Kawano, Ichiro Maruko, Hideki Koizumi, Tomohiro Iida
PURPOSE: To determine the relationship between the clinical findings and the response to ranibizumab therapy in eyes with macular edema associated with branch retinal vein occlusion. METHODS: We reviewed the medical records of 68 patients with macular edema associated with a branch retinal vein occlusion. The patients were placed in the refractory group if the central foveal thickness remained more than 250 μm throughout the 6-month study period despite the ranibizumab therapy; otherwise, they were placed in the responsive group...
May 10, 2017: Retina
https://www.readbyqxmd.com/read/28485211/molecular-diversity-of-tuliposide-b-converting-enzyme-in-tulip-tulipa-gesneriana-identification-of-the-root-specific-isozyme
#18
Taiji Nomura, Ayaka Ueno, Shinjiro Ogita, Yasuo Kato
6-Tuliposide B (PosB) is a glucose ester accumulated in tulip (Tulipa gesneriana) as a major secondary metabolite. PosB serves as the precursor of the antimicrobial lactone tulipalin B (PaB), which is formed by PosB-converting enzyme (TCEB). The gene TgTCEB1, encoding a TCEB, is transcribed in tulip pollen but scarcely transcribed in other tissues (e.g. roots) even though those tissues show high TCEB activity. This led to the prediction of the presence of a TCEB isozyme with distinct tissue specificity. Herein, we describe the identification of the TgTCEB-R gene from roots via native enzyme purification; this gene is a paralog of TgTCEB1...
June 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28479934/ultrastructural-and-biochemical-aspects-of-matrix-vesicle-mediated-mineralization
#19
REVIEW
Tomoka Hasegawa, Tomomaya Yamamoto, Erika Tsuchiya, Hiromi Hongo, Kanako Tsuboi, Ai Kudo, Miki Abe, Taiji Yoshida, Tomoya Nagai, Naznin Khadiza, Ayako Yokoyama, Kimimitsu Oda, Hidehiro Ozawa, Paulo Henrique Luiz de Freitas, Minqi Li, Norio Amizuka
Matrix vesicle-mediated mineralization is an orchestrated sequence of ultrastructural and biochemical events that lead to crystal nucleation and growth. The influx of phosphate ions into the matrix vesicle is mediated by several proteins such as TNAP, ENPP1, Pit1, annexin and so forth. The catalytic activity of ENPP1 generates pyrophosphate (PPi) using extracellular ATPs as a substrate, and the resultant PPi prevents crystal overgrowth. However, TNAP hydrolyzes PPi into phosphate ion monomers, which are then transported into the matrix vesicle through Pit1...
May 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28458762/bacteremia-or-pseudobacteremia-review-of-pseudomonas-fluorescens-infections
#20
Takeshi Nishimura, Kenji Hattori, Akihiko Inoue, Taiji Ishii, Tetsuya Yumoto, Kohei Tsukahara, Astunori Nakao, Satoshi Ishihara, Shinichi Nakayama
No abstract text is available yet for this article.
2017: World Journal of Emergency Medicine
keyword
keyword
43585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"