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https://www.readbyqxmd.com/read/28818376/an-overview-on-the-strategies-to-exploit-rice-endosperm-as-production-platform-for-biopharmaceuticals
#1
REVIEW
Fumio Takaiwa, Yuhya Wakasa, Shimpei Hayashi, Taiji Kawakatsu
Cereal seed has been utilized as production platform for high-value biopharmaceutical proteins. Especially, protein bodies (PBs) in seeds are not only natural specialized storage organs of seed storage proteins (SSPs), but also suitable intracellular deposition compartment for recombinant proteins. When various recombinant proteins were produced as secretory proteins by attaching N terminal ER signal peptide and C terminal KDEL endoplasmic reticulum (ER) retention signal or as fusion proteins with SSPs, high amounts of recombinant proteins can be predominantly accumulated in the PBs...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28813167/lipophagy-maintains-energy-homeostasis-in-the-kidney-proximal-tubule-during-prolonged-starvation
#2
Satoshi Minami, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Tomonori Kimura, Jun-Ya Kaimori, Isao Matsui, Takayuki Hamano, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura, Yoshitaka Isaka
Macroautophagy/autophagy is a self-degradation process that combats starvation. Lipids are the main energy source in kidney proximal tubular cells (PTCs). During starvation, PTCs increase fatty acid (FA) uptake, form intracellular lipid droplets (LDs), and hydrolyze them for use. The involvement of autophagy in lipid metabolism in the kidney remains largely unknown. Here, we investigated the autophagy-mediated regulation of renal lipid metabolism during prolonged starvation using PTC-specific Atg5-deficient (atg5-TSKO) mice and an in vitro serum starvation model...
August 16, 2017: Autophagy
https://www.readbyqxmd.com/read/28808069/endothelial-function-is-impaired-in-patients-receiving-antihypertensive-drug-treatment-regardless-of-blood-pressure-level-fmd-j-study-flow-mediated-dilation-japan
#3
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Binti Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
Hypertension is associated with endothelial dysfunction. Blood pressure significantly correlates with endothelial function in antihypertensive drug-naive subjects. The purpose of this study was to determine whether treatment status affects the relationship between blood pressure and endothelial function. We measured flow-mediated vasodilation (FMD) in 2297 subjects, including 1822 antihypertensive drug-naive subjects and 475 treated hypertensive patients. FMD significantly decreased in relation to increase in systolic blood pressure (8...
August 14, 2017: Hypertension
https://www.readbyqxmd.com/read/28794403/chronological-immunolocalization-of-sclerostin-and-fgf23-in-the-mouse-metaphyseal-trabecular-and-cortical-bone
#4
Atsunaka Sakurai, Tomoka Hasegawa, Ai Kudo, Zhao Shen, Tomoya Nagai, Miki Abe, Taiji Yoshida, Hiromi Hongo, Tomomaya Yamamoto, Tsuneyuki Yamamoto, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Minqi Li, Hidehiko Sano, Norio Amizuka
To assess the chronological participation of sclerostin and FGF23 in bone metabolism, this study tracked the immunolocalization of sclerostin and FGF23 in the metaphyses of murine long bones from embryonic day 18 (E18) through 1 day after birth, 1 week, 2 weeks, 4 weeks, 8 weeks, and 20 weeks of age. We have selected two regions in the metaphyseal trabeculae for assessing sclerostin and FGF23 localization: close to the chondro-osseous junction, i.e., bone modeling site even in the adult animals, and the trabecular region distant from the growth plate, where bone remodeling takes place...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28792691/increased-red-blood-cell-volume-distribution-width-important-clinical-implications-in-predicting-gastric-diseases
#5
Taijie Li, Aidan Huang, Meiyu Zhang, Fang Lan, Dawei Zhou, Huiping Wei, Zhiming Liu, Xue Qin
BACKGROUND: The red blood cell distribution width (RDW) is a blood analyzer marker showing the peripheral blood erythrocyte volume heterogeneity parameters. It is a normal diagnosis index of many diseases. This study was performed to evaluate the relationship between the RDW and gastric diseases. METHODS: A total of 189 patients with GC, 68 patients with gastric ulcers, 92 patients with chronic gastritis, and 157 healthy controls were enrolled in this study. Each patient's RDW and other biomarkers were recorded...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28789689/impact-of-cd14-cd16-monocytes-on-plaque-vulnerability-in-diabetic-and-non-diabetic-patients-with-asymptomatic-coronary-artery-disease-a-cross-sectional-study
#6
Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND: Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14(++)CD16(+) monocytes on plaque vulnerability, as assessed by virtual histology intravascular ultrasound (VH-IVUS), as well as their relationship to fluctuating glucose levels in patients with asymptomatic coronary artery disease (CAD). METHODS: Fifty-one patients with asymptomatic CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS evaluation for angiographically mild to moderate lesions, were enrolled in the study...
August 8, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28776225/forced-expression-of-vascular-endothelial-growth-factor-a-in-podocytes-decreases-mesangial-cell-numbers-and-attenuates-endothelial-cell-differentiation-in-the-mouse-glomerulus
#7
Masahiro Suyama, Yoichi Miyazaki, Taiji Matsusaka, Naoki Sugano, Hiroyuki Ueda, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
BACKGROUND: Glomerular podocyte-derived vascular endothelial growth factor (VEGF) is indispensable for the migration and proliferation of glomerular endothelial cells. In contrast, podocyte-specific Vegf overexpression leads to the collapse of glomerular tufts; however, the mechanisms underlying this outcome have not yet been reported. METHODS: To further clarify the effects of elevated levels of Vegf expression on glomerular cells, we established a dual transgenic mouse line in which Vegf was exclusively and inducibly expressed in podocytes under the control of the "Tet-on system" (Podocin-rtTA/TetO-Vegf164 mice)...
August 3, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28731076/simple-gd-3-neu5nac-complexation-results-in-nmr-chemical-shift-asymmetries-of-structurally-equivalent-complex-type-n-glycan-branches
#8
Konstantin Usachev, Yoshiki Yamaguchi, Masayuki Takamatsu, Nataliya Pavlova, Vladimir Klochkov, Almira Kurbangalieva, Takefumi Murase, Taiji Shimoda, Katsunori Tanaka
In the present Communication, we propose a quite simple but previously overlooked approach for conveniently analyzing, assigning, and extracting sialic acid-containing N-glycan structures using high-resolution NMR spectroscopy without pre-installing metal chelators. Paramagnetic metals, such as Gd(3+), appear to bind to the carboxyl groups of N-acetylneuraminic acid when introduced at room temperature, leading to the measurement of nonequivalent proton and carbon NMR spectral signals among otherwise "identical" glycan branched structures...
August 7, 2017: Analyst
https://www.readbyqxmd.com/read/28711531/transdural-indocyanine-green-videography-for-sta-mca-bypass-technical-note
#9
Hiroshi Yokota, Taiji Yonezawa, Tomonori Yamada, Seisuke Miyamae, Taekyun Kim, Yoshiaki Takamura, Katsuya Masui, Shuta Aketa
BACKGROUND: Neurosurgical application of indocyanine green (ICG) videography prior to performing a dural opening has been reported as transdural ICG videography and used during surgery of meningiomas associated with venous sinuses, as well as cranial and spinal arteriovenous malformations. However, its use for a superficial temporal artery to middle cerebral artery (STA-MCA) bypass has not been reported. METHODS: We performed a retrospective analysis of medical records of patients who underwent a transdural ICG videography technique during STA-MCA bypass procedures performed between January 2012 and March 2015...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709637/tubulointerstitial-fibrosis-can-sensitize-the-kidney-to-subsequent-glomerular-injury
#10
Beom Jin Lim, Jae Won Yang, Jun Zou, Jianyong Zhong, Taiji Matsusaka, Ira Pastan, Ming-Zhi Zhang, Raymond C Harris, Hai-Chun Yang, Agnes B Fogo
Chronic glomerular injury is associated with eventual development of tubulointerstitial fibrosis. Here we aimed to assess whether, and how, mild chronic tubulointerstitial injury affects glomeruli. For this, we generated mice expressing different toxin receptors, one on their proximal tubular epithelial cells (diphtheria toxin receptor [DTR]) and the other only on podocytes (human CD25 [IL-2R] driven by the nephrin promoter [Nep25]), allowing serial induction of tubule-specific and glomerular (podocyte)-specific injury, respectively...
July 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28707336/mechanical-role-of-the-spatial-patterns-of-contractile-cells-in-invagination-of-growing-epithelial-tissue
#11
Yasuhiro Inoue, Tadashi Watanabe, Satoru Okuda, Taiji Adachi
Epithelial invagination is one of the fundamental deformation modes during morphogenesis, and is essential for deriving the three-dimensional shapes of organs from a flat epithelial sheet. Invagination occurs in an orderly manner according to the spatial pattern of the contractile cells; however, it remains elusive how tissue deformation can be caused by cellular activity in the patterned region. In this study, we investigated the mechanical role of the spatial patterns of the contractile cells in invagination of growing tissue using multicellular dynamics simulations...
July 13, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28704528/retraction-association-between-polymorphism-of-the-interleukin-13-gene-and-susceptibility-to-hepatocellular-carcinoma-in-the-chinese-population
#12
Yan Deng, Ming Xie, Li Xie, Jian Wang, Taijie Li, Yu He, Ruolin Li, Shan Li, Xue Qin
No abstract text is available yet for this article.
2017: PloS One
https://www.readbyqxmd.com/read/28702181/the-major-thoracic-vascular-invasion-of-lung-cancer
#13
Soichi Oka, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Yoshinobu Ichiki, Shohei Shimajiri, Takatoshi Aoki, Fumihiro Tanaka
BACKGROUND: We actually investigated the surgical and pathological findings in cases which tumor invasion of the major thoracic vessels was suspected based on the preoperative Computed tomography (CT) findings. MATERIALS AND METHODS: We retrospectively reviewed our prospective database of all patients, who underwent lung resection for lung cancer from 2012 to 2014. 387 patients underwent lung cancer surgery. Among these patients, we analyzed 30 patients in whom pulmonary artery (PA) invasion was suspected and 11 patients in whom pulmonary vein (PV) or left atrium (LA) invasion was suspected based on the preoperative CT findings...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28697750/association-of-lifestyle-and-body-structure-to-ocular-axial-length-in-japanese-elementary-school-children
#14
Hiroto Terasaki, Takehiro Yamashita, Naoya Yoshihara, Yuya Kii, Taiji Sakamoto
BACKGROUND: The purpose of this study is to determine whether the lifestyle and body stature are significantly associated with the axial length (AL) of the eyes of Japanese third grade students. METHODS: A prospective, cross sectional, observational study was performed on 122 third grade students consisting of 61 boys and 61 girls ages 8 to 9 years. The AL, body height, body weight, and body mass index (BMI) were measured. The lifestyle was determined by activities such as the daily duration of indoor studying, television viewing, use of computers and smart phones, outdoor activity time, bed time, Japanese or Western dietary habits, and parental myopia were investigated by a questionnaire with three or five grade levels...
July 12, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28697497/one-year-outcomes-following-intravitreal-aflibercept-for-polypoidal-choroidal-vasculopathy-in-japanese-patients-the-apollo-study
#15
Yuji Oshima, Kenichi Kimoto, Noriko Yoshida, Kimihiko Fujisawa, Shozo Sonoda, Toshiaki Kubota, Toshinori Murata, Taiji Sakamoto, Shigeo Yoshida, Koh-Hei Sonoda, Tatsuro Ishibashi
PURPOSE: To evaluate 1-year outcomes of intravitreal injections of aflibercept (IVA) in Japanese polypoidal choroidal vasculopathy (PCV) patients. METHODS: In this prospective, open-label, single-arm multicenter clinical trial, treatment-naïve PCV patients received IVA (2.0 mg) every 2 months, after 3 initial monthly doses. The primary endpoint assessed was the proportion of patients maintaining baseline best-corrected visual acuity (BCVA) at 1 year. RESULTS: Fifty eyes with PCV were included in the study...
July 12, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28695497/comparison-of-ctac-and-prone-imaging-for-the-detection-of-coronary-artery-disease-using-czt-spect
#16
Shimpei Ito, Akihiro Endo, Taiji Okada, Taku Nakamura, Takashi Sugamori, Nobuyuki Takahashi, Hiroyuki Yoshitomi, Kazuaki Tanabe
BACKGROUND: Cadmium-zinc-telluride (CZT) cameras have improved the evaluation of patients with chest pain. However, inferior/inferolateral attenuation artifacts similar to those seen with conventional Anger cameras persist. We added prone acquisitions and CT attenuation correction (CTAC) to the standard supine image acquisition and analyzed the resulting examinations. METHODS AND RESULTS: Seventy-two patients referred for invasive coronary angiography (CAG), and who also underwent rest/stress myocardial perfusion imaging (MPI) on a CZT camera in the supine and prone positions plus CTAC imaging, to examine known or suspected CAD between April 2013 and March 2014 were included...
July 10, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28690284/association-between-waist-to-height-ratio-and-endothelial-dysfunction-in-patients-with-morbidity%C3%A3-a-report-from-the-fmd-j-study
#17
Akihiro Tokushige, Shinichiro Ueda, Hirofumi Tomiyama, Mituru Ohishi, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Tomoko Ishizu, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Akira Yamashina
BACKGROUND: Waist circumference (WC), waist-to-height ratio (WHtR) and body mass index (BMI) are known as easy anthropometric markers of abnormal obesity and screening tools for predicting cardiovascular outcomes, but which indices are best is unclear. We therefore investigated the superiority and association between each index and low flow-mediated dilatation (FMD) as a surrogate marker for cardiovascular outcomes in patients with morbidity in a large Japanese prospective cohort.Methods and Results:A total of 1,645 Japanese patients who had coronary artery disease and hypertension or diabetes mellitus were enrolled, and 1,087 of them were analyzed...
July 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28689168/systemic-diseases-in-patients-with-htlv-1-associated-uveitis
#18
Kumiko Nakao, Noriko Abematsu, Taiji Sakamoto
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) carriers may develop severe systemic diseases, such as adult T cell leukaemia (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This study aims to investigate systemic diseases of HTLV-1 carriers who had developed HTLV-1-associated uveitis (HAU). METHODS: We investigated the occurrence of systemic diseases in 200 patients with HAU by performing a retrospective investigation of their medical records and examining the results of a postal survey...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28684367/endovascular-therapy-for-the-steal-phenomenon-due-to-the-innominate-artery-severe-stenosis-and-bilateral-internal-carotid-artery-severe-stenosis-case-report
#19
Shuta Aketa, Daisuke Wajima, Masahiro Kishi, Yudai Morisaki, Taiji Yonezawa, Ichiro Nakagawa, Hiroyuki Nakase
BACKGROUND: Symptomatic innominate artery stenosis as hemodynamic bilateral cerebral ischemia is uncommon. We present a rare case of an innominate artery origin severe stenosis and bilateral internal carotid artery (ICA) severe stenosis, inducing hemodynamic cerebral ischemia after ipsilateral axillary artery-bilateral femoral artery bypass, and treated with stent replacement of innominate artery and right ICA. CASE REPORT: A 64-year-old female, who had received previously right axillary artery-bilateral femoral artery anastomosis for abdominal aorta high obstruction, had been suffered from chronic dizziness, so visited our department...
July 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28684122/potent-antiobesity-effect-of-a-short-length-peptide-yy-analogue-continuously-administered-in-mice
#20
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Tomoko Asakawa, Hideki Hirabayashi, Nobuyuki Amano, Shiro Takekawa, Tetsuya Ohtaki, Taiji Asami
The gastrointestinal peptide, peptide YY3-36 (PYY3-36) and its shorter peptide analogues have been reported to reduce appetite by activating the neuropeptide Y2 receptor (Y2R), which is associated with obesity and other metabolic diseases. A 14-amino acid PYY analogue, Ac-[d-Pro(24),Cha(27,28,36),Aib(31)]PYY(23-36) (3), showed high binding affinity and agonist activity for the Y2R, similar to that of PYY3-36, but had weak anorectic activity upon continuous administration in lean mice. Three amino acid substitutions [Pya(4)(26), Aib(28), Lys(30)], which contributed to the decreased hydrophobicity of 3, efficiently increased its anorectic activity...
June 23, 2017: Bioorganic & Medicinal Chemistry Letters
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