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https://www.readbyqxmd.com/read/28438540/potent-and-selective-oxytocin-receptor-agonists-without-disulfide-bridges
#1
Yusuke Adachi, Katsuya Sakimura, Yuji Shimizu, Masaharu Nakayama, Yasuko Terao, Takahiko Yano, Taiji Asami
Oxytocin (OT) is a neuropeptide involved in a wide variety of physiological actions, both peripherally and centrally. Many human studies have revealed the potential of OT to treat autism spectrum disorders and schizophrenia. OT interacts with the OT receptor (OTR) as well as vasopressin 1a and 1b receptors (V1aR, V1bR) as an agonist, and agonistic activity for V1aR and V1bR may have a negative impact on the therapeutic effects of OTR agonism in the CNS. An OTR-selective agonistic peptide, FE 202767, in which the structural differences from OT are a sulfide bond instead of a disulfide bond, and N-alkylglycine replacement for Pro at position 7, was reported...
April 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28430144/a-systems-biology-approach-using-transcriptomic-data-reveals-genes-and-pathways-in-porcine-skeletal-muscle-affected-by-dietary-lysine
#2
Taiji Wang, Jean M Feugang, Mark A Crenshaw, Naresh Regmi, John R Blanton, Shengfa F Liao
Nine crossbred finishing barrows (body weight 94.4 ± 6.7 kg) randomly assigned to three dietary treatments were used to investigate the effects of dietary lysine on muscle growth related metabolic and signaling pathways. Muscle samples were collected from the longissimus dorsi of individual pigs after feeding the lysine-deficient (4.30 g/kg), lysine-adequate (7.10 g/kg), or lysine-excess (9.80 g/kg) diet for five weeks, and the total RNA was extracted afterwards. Affymetrix Porcine Gene 1.0 ST Array was used to quantify the expression levels of 19,211 genes...
April 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28429785/natriuretic-peptide-receptor-guanylyl-cyclase-a-pathway-counteracts-glomerular-injury-evoked-by-aldosterone-through-p38-mitogen-activated-protein-kinase-inhibition
#3
Yukiko Kato, Kiyoshi Mori, Masato Kasahara, Keisuke Osaki, Akira Ishii, Keita P Mori, Naohiro Toda, Shoko Ohno, Takashige Kuwabara, Takeshi Tokudome, Ichiro Kishimoto, Moin A Saleem, Taiji Matsusaka, Kazuwa Nakao, Masashi Mukoyama, Motoko Yanagita, Hideki Yokoi
Guanylyl cyclase-A (GC-A) signaling, a natriuretic peptide receptor, exerts renoprotective effects by stimulating natriuresis and reducing blood pressure. Previously we demonstrated massive albuminuria with hypertension in uninephrectomized, aldosterone-infused, and high salt-fed (ALDO) systemic GC-A KO mice with enhanced phosphorylation of p38 mitogen-activated protein kinase (MAPK) in podocytes. In the present study, we examined the interaction between p38 MAPK and GC-A signaling. The administration of FR167653, p38 MAPK inhibitor, reduced systolic blood pressure (SBP), urinary albumin excretion, segmental sclerosis, podocyte injury, and apoptosis...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412624/effects-of-1-25-dihydroxyvitamin-d3-in-an-ovalbumin-induced-allergic-rhinitis-model
#4
Baiwen Chen, Shenhong Qu, Min Li, Linsong Ye, Shaojie Zhang, Taijie Qin, Hua Fan
IL-17-producing Th17 cells play an important role in allergic airway diseases, but their local expression and regulation in allergic rhinitis (AR) is not well understood. This study investigated the effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on T-bet expression, Th1 cells, Th2 cells, Th17 cells and IL-33-positive epithelial cells in AR. C57BL/6 mice were intranasally sensitized and challenged with ovalbumin (OVA), and 1,25-(OH)2D3 was intraperitoneally injected into AR mice. Cytokine levels were measured with enzyme-linked immunosorbent assays, phenotypic analysis of Th1, Th2 and Th17 cells in the spleen was completed with flow cytometry, and the CD4(+)IL-17(+) cells in the Nasopharynx-associated lymphoid tissue (NALT) and IL-33-positive cells in nasal mucosa was evaluated with immunofluorescence microscopy...
April 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28389725/estimation-of-human-body-volume-bv-from-anthropometric-measurements-based-on-three-dimensional-3d-scan-technique
#5
Xingguo Liu, Jianwei Niu, Linghua Ran, Taijie Liu
BACKGROUND: This study aimed to develop estimation formulae for the total human body volume (BV) of adult males using anthropometric measurements based on a three-dimensional (3D) scanning technique. Noninvasive and reliable methods to predict the total BV from anthropometric measurements based on a 3D scan technique were addressed in detail. METHODS: A regression analysis of BV based on four key measurements was conducted for approximately 160 adult male subjects...
April 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28380826/optimal-design-of-4lp-mode-multicore-fibers-for-high-spatial-multiplicity
#6
Yuki Tobita, Takeshi Fujisawa, Taiji Sakamoto, Takashi Matsui, Shota Saitoh, Katsuhiro Takenaga, Kazuhiko Aikawa, Shinichi Aozasa, Kazuhide Nakajima, Kunimasa Saitoh
High spatial multiplicity fiber designs are presented for homogeneous and heterogeneous 4LP-mode multicore fibers (MCFs) that support six spatial modes per core. The high-spatial-density 4LP-mode MCF design methodology is explained in detail. The influence of the number of cores on the cladding diameter (D<sub>cl</sub>) and relative core multiplicity factor (RCMF) is investigated. The optimal core designs and MCF layouts with square and triangular lattices maintain glass fiber reliability (maximum D<sub>cl</sub> = 250 μm)...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28380067/does-tai-chi-relieve-fatigue-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Yu Xiang, Liming Lu, Xiankun Chen, Zehuai Wen
BACKGROUND: Fatigue is not only a familiar symptom in our daily lives, but also a common ailment that affects all of our bodily systems. Several randomized controlled trials (RCTs) have proven Tai Chi to be beneficial for patients suffering from fatigue, however conclusive evidence is still lacking. A systematic review and meta-analysis was performed on all RCTs reporting the effects of Tai Chi for fatigue. METHODS: In the end of April 2016, seven electronic databases were searched for RCTs involving Tai Chi for fatigue...
2017: PloS One
https://www.readbyqxmd.com/read/28353592/the-effect-of-mdr1-c3435t-polymorphism-on-the-eradication-rate-of-h-pylori-infection-in-ppi-based-triple-therapy-a-meta-analysis
#8
Meng Li, Taijie Li, Shihui Guo, Hongjie Liang, Dunke Jiang
BACKGROUND: Several studies have reported that multidrug resistance gene 1 (MDR1) C3435T polymorphism was associated with the rate of Helicobacter pylori (H. pylori) eradication in proton pump inhibitor (PPI)-based triple therapy. However, the conclusions were inconsistent. Therefore, this meta-analysis was conducted to evaluate the impact of MDR1 C3435T polymorphism on H. pylori eradication by PPI-based triple therapy. METHODS: Seven eligible studies published up to August 2016 and including 1019 patients were identified by searching the Chinese Biomedical Literature database, Wan fang, PubMed, and the Web of Science electronic databases...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28349592/clinical-impact-of-surveillance-colonoscopy-using-magnification-without-diminutive-polyp-removal
#9
Yuki Ninomiya, Shiro Oka, Shinji Tanaka, Kazuki Boda, Ken Yamashita, Kyoku Sumimoto, Daiki Hirano, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Taiji Matsuo, Kazuaki Chayama
BACKGROUND AND AIM: Endoscopic removal of all adenomas during colonoscopy is recommended in Western countries. This study evaluated the usefulness of magnifying colonoscopy without removal of diminutive (≤ 5 mm) colorectal polyps. METHODS: Patients with diminutive polyps who were observed for over 5 years using magnification at Hiroshima University Hospital were selected retrospectively. Lesions ≥ 6 mm in size, depressed lesions, and lesions with type V pit pattern were indications for endoscopic resection...
March 28, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28342686/taiji-tai-chi-for-fall-prevention-in-the-elderly-training-the-trainers-evaluation-project
#10
Lucy Bartimole, Mary A Fristad
Falls in the elderly are common and a major, costly health problem. Taiji addresses many issues related to fall risk. We determined whether intensive weekend training can sufficiently train persons who have baseline familiarity with Taiji to model and teach fundamentals of Taiji to the elderly. Prior to training, registrants received a manual, video and online links for review and practice. Assessments were completed pre-/post-training. Training occurred in four cities of one state. 34 adults completed training, two did not complete evaluations (ns = 12, 13, 4, and 5 at the four sites)...
February 24, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28334771/efficacy-and-safety-of-a-3-month-dosing-regimen-of-degarelix-in-japanese-patients-with-prostate-cancer-a-phase-ii-maintenance-dose-finding-study
#11
Seiichiro Ozono, Taiji Tsukamoto, Seiji Naito, Yasuo Ohashi, Takeshi Ueda, Tsutomu Nishiyama, Hideki Maeda, Hidehito Kusuoka, Rio Akazawa, Mototsugu Ito, Hideyuki Akaza
Objective: To evaluate the efficacy and safety of degarelix 3-month depot in Japanese patients with prostate cancer. Methods: In this Phase II, open-label, parallel-group study, 155 Japanese prostate cancer patients were randomized to treatment with degarelix administered subcutaneously at a maintenance dose of 360 or 480 mg every 84 days for 12 months, after receiving an initial dose of 240 mg. The primary endpoint was the cumulative probability of serum testosterone ≤0...
February 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28319546/gastric-fluid-volume-change-after-oral-rehydration-solution-intake-in-morbidly-obese-and-normal-controls-a-magnetic-resonance-imaging-based-analysis
#12
Toshie Shiraishi, Dai Kurosaki, Mitsuyo Nakamura, Taiji Yazaki, Satomi Kobinata, Yosuke Seki, Kazunori Kasama, Hideki Taniguchi
BACKGROUND: Although preoperative fluid intake 2 hours before anesthesia is generally considered safe, there are concerns about delayed gastric emptying in obese subjects. In this study, the gastric fluid volume (GFV) change in morbidly obese subjects was investigated after ingesting an oral rehydration solution (ORS) and then compared with that in nonobese subjects. METHODS: GFV change over time after the ingestion of 500 mL of ORS containing 2.5% carbohydrate (OS-1) was measured in 10 morbidly obese subjects (body mass index [BMI], >35) scheduled for bariatric surgery and 10 nonobese (BMI, 19-24) using magnetic resonance imaging...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28301959/utility-of-clinico-biological-data-for-long-term-prognosis-of-head-and-neck-terminal-cancer
#13
Taiji Kawasaki, Koichiro Wasano, Sayuri Yamamoto, Shuta Tomisato, Kaoru Ogawa
OBJECTIVE: The prognosis of terminal head and neck cancer is traditionally determined using indices such as the palliative prognosis index. We aimed to develop an alternative prognosis index using clinico-biological data. METHODS: This retrospective case-series study included 33 head and neck cancer patients whose cancer recurred despite receiving radiation therapy between April 2010 and April 2014. Clinico-biological data were collected the day patients were diagnosed as terminal...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28297688/-a-case-of-a-pituitary-adenoma-diagnosed-as-carney-complex-syndrome-in-an-older-female-patient
#14
Ai Okamoto, Daisuke Wajima, Rinsei Tei, Yasushi Shin, Misato Inoue, Shuta Aketa, Taiji Yonezawa
Carney complex syndrome is an autosomal dominant familial tumor syndrome first described by Carney et al. in 1985. The diagnostic criteria include endocrine hyperactivity and spotty skin pigmentation. A 73-year-old woman with cerebral infarction was referred to our department because her brain magnetic resonance imaging(MRI)revealed a pituitary tumor. Her blood tests revealed elevated levels of growth hormone(GH), thyroid stimulating hormone(TSH), and insulin-like growth factor-1(IGF-1). We suspected the presence of a GH-secreting tumor and performed the operation...
March 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28292270/short-term-effects-of-intravitreal-ranibizumab-therapy-on-diabetic-macular-edema
#15
Yoshiro Minami, Taiji Nagaoka, Akihiro Ishibazawa, Akitoshi Yoshida
BACKGROUND: The short-term effects of intravitreal ranibizumab (IVR) on diabetic macular edema (DME) remains unclear. We assessed the short-term effects of IVR on DME. METHODS: Eighteen eyes of 14 patients with DME were enrolled in this prospective interventional case series. After intravitreal ranibizumab was injected into treatment-naïve eyes with DME, we measured the foveal thickness (FT) before and 2 h, 1 day, 1 week, and 1 month later and the best-corrected visual acuity (BCVA) at all times except 2 h and compared the changes to baseline (ΔFT and ΔVA)...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28291683/a-pegylated-analog-of-short-length-neuromedin-u-with-potent-anorectic-and-anti-obesity-effects
#16
Hiroshi Inooka, Kotaro Sakamoto, Tokuyuki Shinohara, Yasushi Masuda, Michiko Terada, Satoshi Kumano, Kotaro Yokoyama, Jiro Noguchi, Naoki Nishizawa, Hidenori Kamiguchi, Hisashi Fujita, Taiji Asami, Shiro Takekawa, Tetsuya Ohtaki
Neuromedin U (NMU) is a neuropeptide known to regulate food intake and energy homeostasis that is widely distributed in the gastrointestinal tract, hypothalamus, and pituitary. A short form of NMU, porcine NMU-8 has potent agonist activity for the receptors NMUR1 and NMUR2; however, its short half-life precludes its effective use in vivo. To address this limitation, we designed and synthesized NMU-8 analogs modified by polyethylene glycol (PEG) with a molecular weight of 30kDa (PEG30k) via a variety of linkers (i...
February 21, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28287388/kerboull-type-plate-in-a-direct-anterior-approach-for-severe-bone-defects-at-primary-total-hip-arthroplasty-technical-note
#17
Mikio Matsumoto, Tomonori Baba, Hironori Ochi, Yu Ozaki, Taiji Watari, Yasuhiro Homma, Kazuo Kaneko
INTRODUCTION: For cases with extensive acetabular bone defects, we perform surgery combining the Kerboull-type (KT) plate and bone graft through direct anterior approach (DAA) in primary total hip arthroplasty (THA) requiring acetabular reconstruction as minimally invasive surgery. This paper provides the details of the surgical procedure. METHODS: The basic structure of the Kerboull-type plate is a cruciform plate. Since the hook of the Kerboull-type plate has to be applied to the tear drop, a space for it was exposed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28284862/investigation-on-cellular-uptake-and-pharmacodynamics-of-dock2-inhibitory-peptides-conjugated-with-cell-penetrating-peptides
#18
Yusuke Adachi, Kotaro Sakamoto, Tadashi Umemoto, Yasunori Fukuda, Akiyoshi Tani, Taiji Asami
Protein-protein interaction between dedicator of cytokinesis 2 (DOCK2) and Ras-related C3 botulinum toxin substrate 1 (Rac1) is an attractive intracellular target for transplant rejection and inflammatory diseases. Recently, DOCK2-selective inhibitory peptides have been discovered, and conjugation with oligoarginine cell-penetrating peptide (CPP) improved inhibitory activity in a cell migration assay. Although a number of CPPs have been reported, oligoarginine was only one example introduced to the inhibitory peptides...
February 13, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28252186/taste-related-sensations-in-old-age
#19
REVIEW
Taiji Ogawa, Michael J Annear, Kazunori Ikebe, Yoshinobu Maeda
BACKGROUND: The sense of taste is important as it allows for assessment of nutritional value, safety, and quality of foods as well as for food enjoyment and quality of life. Several factors are suggested to be associated with taste sensitivity, and higher prevalence of taste disorder has been reported among older adults. This review focused on the reported causes and correlates of taste decline in older adults, with the of aim to consolidating existing evidence and identifying gaps and limitations...
March 2, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28251561/platelet-rich-fibrin-prepared-from-stored-whole-blood-samples
#20
Kazushige Isobe, Masashi Suzuki, Taisuke Watanabe, Yutaka Kitamura, Taiji Suzuki, Hideo Kawabata, Masayuki Nakamura, Toshimitsu Okudera, Hajime Okudera, Kohya Uematsu, Koh Nakata, Takaaki Tanaka, Tomoyuki Kawase
BACKGROUND: In regenerative therapy, self-clotted platelet concentrates, such as platelet-rich fibrin (PRF), are generally prepared on-site and are immediately used for treatment. If blood samples or prepared clots can be preserved for several days, their clinical applicability will expand. Here, we prepared PRF from stored whole-blood samples and examined their characteristics. METHODS: Blood samples were collected from non-smoking, healthy male donors (aged 27-67 years, N = 6), and PRF clots were prepared immediately or after storage for 1-2 days...
December 2017: International Journal of Implant Dentistry
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