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Intracerebral pressure

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https://www.readbyqxmd.com/read/28104834/disparities-in-the-use-of-seizure-medications-after-intracerebral-hemorrhage
#1
Andrew M Naidech, Paloma Toledo, Shyam Prabhakaran, Jane L Holl
BACKGROUND AND PURPOSE: We investigated potential disparities in the use of prophylactic seizure medications in patients with intracerebral hemorrhage. METHODS: Review of multicenter electronic health record (EHR) data with simultaneous prospective data recording. EHR data were retrieved from HealthLNK, a multicenter EHR repository in Chicago, Illinois, from 2006 to 2012 (multicenter cohort). Additional data were prospectively coded (single-center cohort) from 2007 through 2015...
January 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28046202/intracerebral-injections-and-ultrastructural-analysis-of-high-pressure-frozen-brain-tissue
#2
Marie-Theres Weil, Torben Ruhwedel, Wiebke Möbius, Mikael Simons
Intracerebral injections are an invasive method to bypass the blood brain barrier and are widely used to study molecular and cellular mechanisms of the central nervous system. The administered substances are injected directly at the site of interest, executing their effect locally. By combining injections in the rat brain with state-of-the-art electron microscopy, subtle changes in ultrastructure of the nervous tissue can be detected prior to overt damage or disease. The protocol presented here involves stereotactic injection into the corpus callosum of Lewis rats and the cryopreparation of freshly dissected tissue for electron microscopy...
January 3, 2017: Current Protocols in Neuroscience
https://www.readbyqxmd.com/read/28040989/n-terminal-pro-brain-natriuretic-peptide-concentrations-after-hypertensive-intracerebral-hemorrhage
#3
Fei Li, Qian-Xue Chen, Shou-Gui Xiang, Shi-Zhun Yuan, Xi-Zhen Xu
INTRODUCTION: The role of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with hypertensive intracerebral hemorrhage (HICH) is poorly understood. This study aimed to investigate the secretion pattern of NT-proBNP in patients with HICH and to assess its relationship with hematoma size, hyponatremia, and intracranial pressure (ICP). METHODS: This prospective study enrolled 147 isolated patients with HICH. Blood samples were obtained from each patient, and values of serum NT-proBNP, hematoma size, blood sodium, and ICP were collected for each patient...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28007486/-trends-in-computed-tomography-characteristics-intracranial-pressure-monitoring-and-surgical-management-in-severe-traumatic-brain-injury-analysis-of-a-data-base-of-the-past-25-years-in-a-neurosurgery-department
#4
Pedro A Gómez, Ana M Castaño-León, David Lora, Santiago Cepeda, Alfonso Lagares
OBJECTIVE: To describe the radiological characteristics, surgical indications, procedures, and intracranial pressure monitoring of a representative cohort of severe traumatic brain injury (sTBI) cases collected over the past 25years, and to analyse the changes that have occurred by dividing the period into 3 equal time periods. METHODS: An observational cohort study was conducted on consecutive adult patients (>14years of age) with severe closed TBI (Glasgow Coma Scale score [GCS]≤8) who were admitted during the first 48hours after injury to the Hospital 12 de Octubre from 1987 to 2012...
December 19, 2016: Neurocirugía
https://www.readbyqxmd.com/read/28004328/management-of-acute-hypertensive-response-in-intracerebral-hemorrhage-patients-after-atach-2-trial
#5
Shahram Majidi, Jose I Suarez, Adnan I Qureshi
Acute hypertensive response is elevation of systolic blood pressure (SBP) in the first 24 h after symptom onset which is highly prevalent in patients with intracerebral hemorrhage (ICH). Observational studies suggested association between acute hypertensive response and hematoma expansion, peri-hematoma edema and death and disability, and possible reduction in these adverse outcomes with treatment of acute hypertensive response. Recent clinical trials have focused on determining the clinical efficacy of early intensive SBP reduction in ICH patients...
December 21, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/28003010/endothelial-progenitor-cells-as-a-therapeutic-approach-for-intracerebral-hemorrhage
#6
Juan Pías-Peleteiro, Francisco Campos, María Pérez-Mato, Esteban López-Arias, Manuel Rodríguez-Yáñez, José Castillo, Tomás Sobrino
BACKGROUND: Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, a leading cause of death and disability in developed countries. Therapeutic options are notably limited. There is no specific pharmacological treatment, and early surgery has few indications that represent only a small clinically relevant survival advantage. It is therefore mandatory to investigate repairing processes after ICH in order to develop related therapeutic strategies. METHODS: The goal of this review is to discuss the current status of knowledge about the potential therapeutic role of endothelial progenitor cells (EPCs) in ICH, as well as the possible molecular mechanisms and future perspectives...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28003003/endothelial-progenitor-cells-as-a-therapeutic-approach-for-intracerebral-hemorrhage
#7
Juan Pías-Peleteiro, Francisco Campos, María Pérez-Mato, Esteban López-Arias, Manuel Rodríguez-Yáñez, José Castillo, Tomás Sobrino
BACKGROUND: Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, a leading cause of death and disability in developed countries. Therapeutic options are notably limited. There is no specific pharmacological treatment, and early surgery has few indications that represent only a small clinically relevant survival advantage. It is therefore mandatory to investigate repairing processes after ICH in order to develop related therapeutic strategies. METHODS: The goal of this review is to discuss the current status of knowledge about the potential therapeutic role of endothelial progenitor cells (EPCs) in ICH, as well as the possible molecular mechanisms and future perspectives...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28000127/intensive-care-unit-admission-for-patients-in-the-interact2-ich-blood-pressure-treatment-trial-characteristics-predictors-and-outcomes
#8
Katja E Wartenberg, Xia Wang, Paula Muñoz-Venturelli, Alejandro A Rabinstein, Pablo M Lavados, Craig S Anderson, Thompson Robinson
BACKGROUND: Wide variation exists in criteria for accessing intensive care unit (ICU) facilities for managing patients with critical illnesses such as acute intracerebral hemorrhage (ICH). We aimed to determine the predictors of admission, length of stay, and outcome for ICU among participants of the main Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of 2839 ICH patients (<6 h) and elevated systolic blood pressure (SBP) allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) BP-lowering treatment...
December 20, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27965078/a-high-resolution-analysis-on-the-meteorological-influences-on-spontaneous-intracerebral-hemorrhage-incidence
#9
Marian Christoph Neidert, Michael Sprenger, Marius Mader, Giuseppe Esposito, Jonas Aurel Hosp, Oliver Bozinov, Luca Regli, Jan-Karl Burkhardt
OBJECTIVE: To investigate the influence of meteorological factors on the incidence of intracerebral hemorrhage (ICH). METHODS: We included 295 ICH admissions between 2005 and 2013. The hourly meteorological parameters considered are: surface pressure, temperature, relative humidity, wind gusts and precipitation. To minimize confounding effects of seasonality, data were analyzed using the following three complementary statistical approaches: (i) deviation of daily measure from the 10-year monthly mean at the day of ictus; (ii) deviation from monthly average with respect to changes in daily measures between the day of ictus and two days before; (iii) evolution of daily measures from 5 days before to 5 days after the ICH occurred...
December 10, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27927936/blood-pressure-levels-and-the-risk-of-intracerebral-hemorrhage-after-ischemic-stroke
#10
Nina A Hilkens, Jacoba P Greving, Ale Algra, Catharina J M Klijn
OBJECTIVE: To investigate the association between blood pressure (BP) levels and risk of intracerebral hemorrhage (ICH) after ischemic stroke. METHODS: We performed a post hoc analysis of data from the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial, a randomized clinical trial including 20,332 patients with recent noncardioembolic ischemic stroke. BP measurements were divided into predefined categories. We calculated incidence rates per BP category and performed multivariable Cox regression analysis with systolic blood pressure (SBP) and diastolic blood pressure (DBP) categories as time-dependent covariables...
December 7, 2016: Neurology
https://www.readbyqxmd.com/read/27919055/associations-with-health-related-quality-of-life-after-intracerebral-haemorrhage-pooled-analysis-of-interact-studies
#11
Candice Delcourt, Danni Zheng, Xiaoying Chen, Maree Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Mark Woodward, Yining Huang, Thompson Robinson, Pablo M Lavados, Richard I Lindley, Christian Stapf, Leo Davies, John Chalmers, Craig S Anderson, Shoichiro Sato
BACKGROUND AND PURPOSE: Limited data exist on health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH). We aimed to determine baseline factors associated with HRQoL among participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trials (INTERACT 1 and 2). METHODS: The INTERACT studies were randomised controlled trials of early intensive blood pressure (BP) lowering in patients with ICH (<6 hours) and elevated systolic BP (150-220 mm Hg)...
January 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27907969/neuroprotection-in-critical-care-neurology
#12
Menno R Germans, Hieronymus D Boogaarts, R Loch Macdonald
Ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury-all have in common early brain injury due to brain tissue destruction, reduced cerebral blood flow and oxygen delivery, and overall substantial morbidity and mortality. The pathophysiology of brain tissue damage likely includes common cellular mechanisms. Neuroprotection has seldom, if ever, been shown to reduce early brain injury. Secondary brain injury develops after these conditions due to macroscopic events such as increased intracranial pressure and reduced cerebral blood flow, as well as cellular processes including vascular damage, inflammation, and apoptotic/necrotic cell death...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27907957/surgical-strategies-for-spontaneous-intracerebral-hemorrhage
#13
Wendy Ziai, J Ricardo Carhuapoma, Paul Nyquist, Daniel F Hanley
In recent decades, the medical and surgical treatment of intracerebral hemorrhage (ICH) have become the focus of a number of scientific investigations. This effort has been led by an international group of neurologists and neurosurgeons with the goal of studying functional recovery and developing new medical and surgical treatments to facilitate improved clinical outcomes. Currently, two of the most pressing ICH investigational goals are (1) early blood pressure control, and (2) safe hematoma volume reduction...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27906426/continuous-monitoring-of-intracranial-pressure-for-prediction-of-postoperative-complications-of-hypertensive-intracerebral-hemorrhage
#14
S-X Yu, Q-S Zhang, Y Yin, Z Liu, J-M Wu, M-X Yang
OBJECTIVE: This study evaluates the value of continuous dynamic monitoring of intracranial pressure (ICP) in patients with hypertensive intracerebral hemorrhage to predict early postoperative complications. PATIENTS AND METHODS: Data from 80 patients treated in our hospital from February 2014 to February 2015 were analyzed. The patients all underwent decompressive craniectomies, and their ICP changes were monitored invasively and continuously for 1 to 7 days after surgery...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27902622/efficacy-and-safety-of-penetration-acupuncture-on-head-for-acute-intracerebral-hemorrhage-a-randomized-controlled-study
#15
Hai-Qiao Wang, Chun-Ling Bao, Zhi-Hua Jiao, Gui-Rong Dong
BACKGROUND: Acupuncture, especially acupuncture treatment on head for acute intracerebral hemorrhage (ICH), has long been disputable. The aim of this study was to evaluate the efficacy and safety of penetration acupuncture on head in patients with acute ICH. METHODS: Eighty-two patients with acute ICH were randomized to receive penetration acupuncture treatment on head combined with conventional treatment (treatment group [TG]) or conventional treatment only (control group [CG])...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27899759/perioperative-antihypertensive-treatment-in-patients-with-spontaneous-intracerebral-hemorrhage
#16
Jun Zheng, Hao Li, Sen Lin, Junpeng Ma, Rui Guo, Lu Ma, Yuan Fang, Meng Tian, Ming Liu, Chao You
BACKGROUND: Studies on antihypertensive treatment for surgical patients with spontaneous intracerebral hemorrhage are insufficient. This pilot study was conducted to investigate the safety of the perioperative intensive blood pressure lowering in surgical patients with spontaneous intracerebral hemorrhage. METHODS: This study was a prospective, parallel, randomized, assessor-blinded trial. Patients allocated to the intensive group received perioperative intensive antihypertensive treatment aiming to achieve a target systolic blood pressure between 120 and 140 mm Hg, whereas the patients in the conservative group received conservative treatment aiming to achieve a target systolic blood pressure between 140 and 180 mm Hg for 7 days...
January 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27895301/acute-blood-pressure-management-in-intracerebral-hemorrhage-equipoise-resists-an-attack
#17
Kenneth Butcher, Magdy Selim
No abstract text is available yet for this article.
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27857926/intracerebral-hemorrhagic-infarction-after-cranioplasty-in-a-patient-with-sinking-skin-flap-syndrome
#18
Jai-Hyuck Han, Mou-Seop Lee
The sinking skin flap syndrome (SSFS) is a rare complication after a large craniectomy. Hemorrhage infarction after a cranioplasty is a very rare complication with only 4 cases to date. We report a case of the patient who underwent an autologous cranioplasty to treat SSFS that developed intracerebral hemorrhage infarction. A 20-year-old male was admitted to our emergency department with stuporous mentality. Emergent decompressive craniectomy (DC) have done. He had suffered from SSFS and fever of unknown origin (FUO) since DC...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27855610/a-review-on-injury-mechanism-of-intracerebral-hemorrhage-in-vehicle-accidents
#19
Fan Li, Honggeng Li, Zhi Xiao, Ronggui Lu, Zhiteng Zhang, Haiyun Zhu, Lihai Ren
BACKGROUND: Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS: A condensed overview is given based on the published studies in biomechanical studies on intracerebral hemorrhage. Animal tests, cadaver tests, accident investigations and numerical simulation are the main method used for the mechanism studies...
November 18, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27847269/intrasylvian-intracerebral-hematomas-associated-with-ruptured-mca-aneurysms-a-single-center-series-and-a-review-of-literature
#20
Yupeng Zhang, Quan Hu, Hao Xue, Mingran Zhang, Jie Shen, Lin Deing, Qinglin Liu, Gang Li
OBJECTIVE: Ruptured MCA aneurysms usually lead to SAH,and several cases will represent concomitant intrasylvian or intracerebral hematomas. The objective of this paper was to compare the clinical and radiographic characteristics with their different outcomes. METHODS: The charts of 30 consecutive patients with ruptured MCA aneurysm related intracranial hematoma were retrospectively reviewed. These patients were dichotomized into ISH group and ICH group by the presence of intrahematomal contrast enhancing vessel (IHCEV), and for patients under open surgery, hematoma type was further confirmed by intraoperative observation...
November 12, 2016: World Neurosurgery
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