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https://www.readbyqxmd.com/read/29141038/depot-specific-inflammation-with-decreased-expression-of-atm2-in-white-adipose-tissues-induced-by-high-margarine-lard-intake
#1
Nannan Wang, Jie Guo, Fuding Liu, Mingxia Wang, Chuntao Li, Lihong Jia, Lingling Zhai, Wei Wei, Yinglong Bai
A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans fatty acids (TFAs)/ saturated fatty acids (SFAs), elaidic acid as a biomarker of margarine intake was used to screen affected adipokines on mature human adipocytes in vitro. Weaned male Wistar rats were fed a high-fat diet enriched with margarine/lard to generate obesity-prone (OP) and obesity-resistant (OR) models, which were then used to explore the inflammatory responses of depot-specific white adipose tissue...
2017: PloS One
https://www.readbyqxmd.com/read/29139246/-systemic-evaluation-and-meta-analysis-of-xianling-gubao-capsule-in-treatment-of-primary-osteoporosis-in-randomized-controlled-trials
#2
Gui-Qian Wang, Xing Liao, Yi-Li Zhang, Yan-Ming Xie
To evaluate the efficacy and safety of Xianling Gubao capsule in the treatment of osteoporosis (OP). Eight Chinese and English databases were retrieved (from establishment to February 2017), and clinical trials were screened according to the preset inclusion criteria and exclusion criteria. Then risk assessment tools were used for quality evaluation of the studies, and data extraction and analysis were conducted by using RevMan 5.3 software for Meta-analysis. A total of 1 895 articles were retrieved, and finally 54 studies were included...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29137457/monoclonal-antibody-that-recognizes-diethoxyphospho-tyrosine-modified-proteins-and-peptides-independent-of-surrounding-amino-acids
#3
Seda Onder, Alicia J Dafferner, Lawrence M Schopfer, Gaoping Xiao, Udaya Yerramalla, Ozden Tacal, Thomas A Blake, Rudolph C Johnson, Oksana Lockridge
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine. Proteins that have no active site serine, for example albumin, are covalently modified on tyrosine and lysine. Chronic illness from pesticide exposure is not explained by inhibition of AChE and BChE. Our goal was to produce a monoclonal antibody that recognizes proteins diethoxyphosphorylated on tyrosine. Diethoxyphosphate-tyrosine adducts for 13 peptides were synthesized...
November 14, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29134673/modified-dixon-based-renal-dynamic-contrast-enhanced-mri-facilitates-automated-registration-and-perfusion-analysis
#4
Anneloes de Boer, Tim Leiner, Eva E Vink, Peter J Blankestijn, Cornelis A T van den Berg
PURPOSE: Renal dynamic contrast-enhanced (DCE) MRI provides information on renal perfusion and filtration. However, clinical implementation is hampered by challenges in postprocessing as a result of misalignment of the kidneys due to respiration. We propose to perform automated image registration using the fat-only images derived from a modified Dixon reconstruction of a dual-echo acquisition because these provide consistent contrast over the dynamic series. METHODS: DCE data of 10 hypertensive patients was used...
November 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29133087/preparation-and-characterization-of-a-novel-biocomposite-based-on-duck-feet-gelatin-as-alternative-to-bovine-gelatin
#5
Ahmadreza Abedinia, Fazilah Ariffin, Nurul Huda, Abdorreza Mohammadi Nafchi
Edible duck feet gelatin (DFG)-based biocomposites with different glycerol (GLY) contents (15%, 25%, and 35% of dried DFG) were prepared. Physicochemical, mechanical, barrier, and heat seal properties of DFG films were characterized and compared as an alternative to bovine gelatin film. Increasing glycerol from 15 to 35% decreased the TS and YM and EB and HS increased, in value of 42.54 to 7.27 and 1240 to 157.10MPa and 22.82 to 50.33% and 42.06 to 347.15N/m respectively. The water vapor permeability (WVP) and oxygen permeability (OP) of films were increased from 4...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29132483/glanular-hypospadias-management-with-modified-circumcision-and-firlit-procedure
#6
Nadeem Iqbal, Ijaz Hussain, Muneeb Ahmad Cheema, Muhammad Taimur Hijazi, Meherunnisa Asif Khan, Omair Ul Haq Lodhi, Saeed Akhter
OBJECTIVE: To document the results of using simple technique of Firlit procedure with modified circumcision for treatment of glanular hypospadias. STUDY DESIGN: Descriptive case series. PLACE AND DURATION OF STUDY: Department of Urology, Shifa International Hospital, Islamabad, from January 2011 till May 2017. METHODOLOGY: The subjects included pediatric patients who underwent repair of glanular hypospadias by using modified circumcision and Firlit procedure...
November 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29132024/a-hilic-uhplc-ms-ms-untargeted-urinary-metabonomics-combined-with-quantitative-analysis-of-five-polar-biomarkers-on-osteoporosis-rats-after-oral-administration-of-gushudan
#7
Xiao Wu, Yue Huang, Jinghan Sun, Yongqing Wen, Feng Qin, Longshan Zhao, Zhili Xiong
A HILIC-UHPLC-MS/MS untargeted urinary metabonomic method combined with quantitative analysis of five potential polar biomarkers in rat urine was developed and validated, to further understand the anti-osteoporosis effect of Gushudan(GSD) and its mechanism on prednisolone-induced osteoporosis(OP) rats in this study. The metabolites were separated and identified on Waters BEH HILIC (2.1mm×100mm, 1.7μm) column using the Waters ACQUITY™ ultra performance liquid chromatography system (Waters Corporation, Milford, USA) coupled with a Micromass Quattro Micro™ API mass spectrometer (Waters Corp, Milford, MA, USA)...
October 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29130989/preoperative-nutritional-optimization-for-crohn-s-disease-patients-can-improve-surgical-outcome
#8
Yael Dreznik, Nir Horesh, Mordechai Gutman, Aviad Gravetz, Imri Amiel, Harel Jacobi, Oded Zmora, Danny Rosin
BACKGROUND: Preoperative preparation of patients with Crohn's disease is challenging and there are no specific guidelines regarding nutritional support. The aim of this study was to assess whether preoperative nutritional support influenced the postoperative outcome. METHODS: A retrospective, cohort study including all Crohn's disease patients who underwent abdominal surgery between 2008 and 2014 was conducted. Patients' characteristics and clinical and surgical data were recorded and analyzed...
November 1, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29128577/pathological-and-3-tesla-volumetric-mr-predictors-of-biochemical-recurrence-after-robotic-assisted-radical-prostatectomy-correlation-with-whole-mount-histopathology
#9
Nelly Tan, Luyao Shen, Pooria Khoshnoodi, Héctor E Alcalá, Weixia Yu, William Hsu, Robert E Reiter, David Y Lu, Steven S Raman
OBJECTIVE: To identify the clinical and MRI variables predictive of biochemical recurrence (BCR) after robotic assisted radical prostatectomy (RALP) in patients who underwent multi-parametric 3 Tesla prostate MR Imaging. METHODS: An IRB approved, HIPAA compliant, a single arm observational study with 3T mpMRI prior to RALP from December 2009 until March 2016 was performed. Clinical, MRI, pathological information and clinical outcome were compiled. Biochemical recurrence was defined as PSA greater > 0...
November 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29127870/concentrations-of-several-phthalates-contaminants-in-egyptian-bottled-water-effects-of-storage-conditions-and-estimate-of-human-exposure
#10
Ghada Zaki, Tamer Shoeib
The occurrence and concentrations of six common phthalates were investigated for the first time in bottled water locally produced in the Egyptian market. The compounds investigated were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), n-butyl benzyl phthalate (BBP), diethyl hexyl phthalate (DEHP), and Di-n-octyl phthalate (D-n-OP). A set of 108 bottled water samples from six different commercial brands of water bottled in transparent polyethylene terephthalate (PET) plastic bottles with high density polyethylene (HDPE) plastic caps were investigated...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29124794/effect-of-home-bleaching-on-the-translucency-of-cad-cam-systems
#11
Muhammet Karci, Necla Demir
PURPOSE: To evaluate the effect of a home bleaching agent (Opalescence PF) on the translucency of CAD/CAM ceramic systems. MATERIALS AND METHODS: The 28 sintered ceramic specimens (IPS Empress CAD and IPS e.max CAD; 15 mm long, 10 mm wide, 1 mm thick) were divided into two subgroups as control and bleaching groups (n = 7). Carbamide peroxide (CP), 16%, home bleaching agent was applied onto the surface of each specimen for 6 hours per day for 7 days. A spectrophotometer (VITA Easyshade Advance) was used to measure the CIE L(*) a(*) b(*) coordinates and the reflectance value (Y) of the specimens on white and black backgrounds...
November 10, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29120255/comparison-of-the-efficacy-of-dexamethasone-nepafenac-and-bromfenac-for-preventing-pseudophakic-cystoid-macular-edema-an-open-label-prospective-randomized-controlled-trial
#12
Claudio Campa, Giulia Salsini, Paolo Perri
PURPOSE: To evaluate the incidence of pseudophakic cystoid macular edema (PCMO) in patients treated with corticosteroids alone or in combination with bromfenac or nepafenac eyedrops after uneventful cataract surgery. MATERIALS AND METHODS: Prospective, randomized, open-label, placebo-controlled clinical trial. Patients who underwent routine cataract surgery with intraocular lens (IOL) implant were randomly divided into three groups receiving either bromfenac or nepafenac in association with dexamethasone or dexamethasone alone (control group) postoperatively...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29118304/pediatric-optic-pathway-hypothalamic-glioma
#13
Yasuo Aihara, Kentaro Chiba, Seiichiro Eguchi, Kosaku Amano, Takakazu Kawamata
Optic pathway/hypothalamic gliomas (OP/HGs) are rare astrocytic tumors that appear more commonly among young children and often are unresectable. They comprise approximately 2% of all central nervous system tumors and account for 3-5% of pediatric intracranial tumors. Initial manifestations are often visual disturbances, endocrinopathies and hypothalamic dysfunction such as the diencephalic syndrome, and sometimes hydrocephalus due to cerebrospinal fluid (CSF) outflow obstruction. In many cases, the tumors are diagnosed late in the clinical course because they silently enlarge...
November 9, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29117613/evaluation-of-the-relation-between-omentin-1-and-vitamin-d-in-postmenopausal-women-with-or-without-osteoporosis
#14
O Dikker, S Bekpinar, Gul Ozdemirler, Mujdat Uysal, Muberra Vardar, Sevgi Atar, Murat Usta, Berrin Huner
Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to bone metabolism. Omentin-1, a 34-kD protein, is released from omental adipose tissue. A few studies indicated the effect of omentin-1 on bone health and bone mineral density (BMD) and the interaction of omentin-1 with vitamin D. Therefore, this study aimed to investigate the relationship between omentin-1, vitamin D, and BMD in postmenopausal women with osteoporosis compared with non-osteoporotic counterparts...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29112966/lengthening-of-knee-flexor-muscles-by-percutaneous-needle-tenotomy-description-of-the-technique-and-preliminary-results
#15
Alexis Schnitzler, François Genêt, Aurélie Diebold, Laurence Mailhan, Claire Jourdan, Philippe Denormandie
BACKGROUND: Knee flexion contractures occur frequently in non-ambulatory, aged persons and persons with central nervous system lesions, rendering positioning and nursing care difficult. There are often risks associated with surgical interventions. OBJECTIVE: To evaluate the effectiveness of percutaneous needle tenotomy to lengthen the knee flexor muscles and improve passive function. METHODS: This was a retrospective study of all patients who underwent percutaneous needle tenotomy between 2012 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29108742/gene-expression-analysis-reveals-chronic-low-level-exposure-to-the-pesticide-diazinon-affects-psychological-disorders-gene-sets-in-the-adult-rat
#16
Claire Y Savy, Ann E Fitchett, Peter G Blain, Christopher M Morris, Sarah J Judge
Chronic low level exposure to organophosphate (OPs) pesticides in adulthood has been linked to adverse neurobehavioural deficits and psychological disorder symptoms, although this remains a contentious issue. The OP-induced biological changes that could underlie these effects are unclear. We assessed gene expression changes following chronic low level exposure to diazinon, a pesticide with a high dietary exposure risk. Adult male rats were orally exposed to diazinon (0, 1, 2mg/kg, 5days a week for 12 weeks)...
November 3, 2017: Toxicology
https://www.readbyqxmd.com/read/29104211/isolation-and-characterization-of-polysaccharides-from-oysters-crassostrea-gigas-with-anti-tumor-activities-using-an-aqueous-two-phase-system
#17
Kit-Leong Cheong, Li-Xuan Xia, Yang Liu
In this study, a simple aqueous two-phase system (ATPS) was employed for concurrent purification of oyster polysaccharides. The chemical structure and anti-tumor activities of purified oyster polysaccharides (OP-1) were also investigated. Under optimal ATPS conditions, oyster polysaccharides can be partitioned in the bottom phase with 67.02% extraction efficiency. The molecular weight of OP-1 was determined as 3480 Da. OP-1 is a (1→4)-α-d-glucosyl backbone and branching points located at O-3 of glucose with a terminal-d-Glcp...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29104016/single-dose-del-nido-cardioplegia-in-minimally-invasive-aortic-valve-surgery
#18
Daniel Ziazadeh, Regina Mater, Ben Himelhoch, Andrew Borgman, Jessica L Parker, Charles L Willekes, Tomasz A Timek
OBJECTIVE: Del Nido cardioplegia (DC) offers prolonged cardiac protection with single dose administration and has been shown to be safe in adult CABG surgery. We set out to evaluate the efficacy of cardiac protection and clinical outcomes of del Nido cardioplegia versus standard blood cardioplegia (BC) in minimally invasive aortic valve surgery. METHODS: From 8/2011 to 5/2016, 178 patients underwent minimally invasive aortic valve replacement (AVR) with BC (n=101) or DC (n= 77)...
November 2, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29100418/contribution-of-gabaa-gabac-and-glycine-receptors-to-rat-dark-adapted-oscillatory-potentials-in-the-time-and-frequency-domain
#19
Jiaman Dai, Juncai He, Gang Wang, Min Wang, Shiying Li, Zheng Qin Yin
Retinal oscillatory potentials (OPs) consist of a series of relatively high-frequency rhythmic wavelets, superimposed onto the ascending phase of the b-wave of the electroretinogram (ERG). However, the origin of OPs is uncertain and methods of measurement of OPs are diverse. In this study, we first isolated OPs from the rat ERG and fitted them with Gabor functions and found that the envelope of the OP contained information about maximum amplitude and time-to-peak to enable satisfactory quantification of the later OPs...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098588/chlorination-disinfection-by-products-and-comparative-cost-analysis-of-chlorination-and-uv-disinfection-in-sewage-treatment-plants-indian-scenario
#20
Surbhi Tak, Arun Kumar
Apart from numerous other well-known drawbacks of chlorination, viz. on-site operational hazards and residual chlorine toxicity, trihalomethane (THM) formation is the major factor that came into limelight in the last 40 years, primarily in drinking water treatment industry. Treated effluent from wastewater treatment plants is also chlorinated and then discharged, indirectly coming in human contact, so there is need to consider THM as a potable as well as wastewater parameter. In this study, THMs were identified in seven sewage treatment plants (STPs) in North India...
November 3, 2017: Environmental Science and Pollution Research International
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