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https://www.readbyqxmd.com/read/28106625/long-term-hearing-results-after-ossiculoplasty
#1
Matthew D Cox, Aaron Trinidade, James Shep Russell, John L Dornhoffer
OBJECTIVES: To determine if the OOPS index is predictive of long-term hearing results after ossiculoplasty. STUDY DESIGN: Case series with retrospective chart review. SETTING: Tertiary care otology practice. PATIENTS: Adult and pediatric patients (3-88 years of age). INTERVENTIONS: Ossiculoplasty with cartilage tympanoplasty, with or without mastoidectomy. OUTCOME MEASURES: Primary outcome measures included short-term hearing results (pure-tone average air-bone gap [PTA-ABG] measured between 60 days and 1 year after surgery), long-term hearing results (PTA-ABG measured ≥5 years after surgery), and the rate of successful ABG closure to ≤20 dB...
January 18, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28102712/bone-morphogenetic-protein-2-and-7-mediate-the-anabolic-function-of-nucleus-pulposus-cells-with-discrete-mechanisms
#2
Victor Yl Leung, Lixiong Zhou, Wai-Kit Tam, Yi Sun, Fengjuan Lv, Guangqian Zhou, Kenneth Mc Cheung
Bone morphogenetic proteins (BMPs) play roles in promoting cell anabolism, especially extracellular matrix production. The difference between BMP members in their capacity to modulate intervertebral disc cell activity is yet to be defined. BMP-7/OP-1 has been shown to retard disc degeneration. We compared the activity of BMP-7 with BMP-2 on nucleus pulposus (NP) cell phenotype and function, and investigated how they differentially affect the gene expression profiles of signaling cascade components in human NP cells under degenerative states...
January 19, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28102095/significance-of-the-ionized-calcium-measurement-to-assess-calcium-status-in-osteopenic-osteoporosis-postmenopausal-outpatients
#3
Letizia Guiducci, Silvia Maffei, Laura Sabatino, Luc Zyw, Debora Battaglia, Alessandro Vannucci, Pietro Di Cecco, Cristina Vassalle
INTRODUCTION: Evaluation of calcium status is important in the osteoporotic risk assessment. Although guidelines indicate total calcium (tCa) as first-line measurement, directly measured ionized calcium (m-iCa), considered as the gold standard, is more and more often required. Aim of this study is to evaluate the agreement between m-iCa, tCa and iCa calculated from a formula based on total calcium and albumin (c-iCa) in osteopenic/osteoporotic postmenopausal outpatients. METHODS: A total of 140 postmenopausal outpatients, 41 osteopenic (OPN) and 99 osteoporotic (OP) were enrolled...
January 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28099651/contribution-of-oswaldo-paulo-forattini-to-public-health-analysis-of-scientific-production
#4
Juliana Gonçalves Reis, Keilla Miki Kobayashi, Helene Mariko Ueno, Cristiane Martins Ribeiro, Telma Abdalla de Oliveira Cardoso
OBJECTIVE: To analyze the main characteristics of the scientific production of Oswaldo Paulo Forattini, researcher and, for 40 years, editor of Revista de Saúde Pública. METHODS: Descriptive study with bibliometric approach conducted in three steps. (1) identification of bibliographic records using the following search strategy: "Oswaldo Paulo Forattini" OR "Forattini OP" OR "Forattini" up information sources Google Scholar, Web of Science, and PubMed, in July 2016, which retrieved 867 records...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28097254/use-of-op-1-rhbmp-7-in-posterolateral-lumbar-arthrodesis
#5
EDITORIAL
Jetan H Badhiwala, Michael G Fehlings
No abstract text is available yet for this article.
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28081352/removing-the-specimen-with-traction-during-robotic-radical-prostatectomy-does-not-cause-a-positive-surgical-margin
#6
Serkan Altınova, Abidin Egemen İşgören, Ziya Akbulut, Muhammet Fuat Özcan, Abdullah Erdem Canda, Ali Fuat Atmaca, Mevlana Derya Balbay
BACKGROUND/AIM: The aim of this study was to gauge whether removal of a specimen with traction during robot-assisted laparoscopic radical prostatectomy causes a positive surgical margin or not. MATERIALS AND METHODS: One hundred and sixty-nine patients with localized prostate cancer who underwent robot-assisted laparoscopic radical prostatectomy from 2009 to 2011 were included in the study. After dividing the patients into two groups, we recorded their characteristics and pre-op/post-op evaluations...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079731/midterm-radiographic-and-functional-outcomes-of-the-anterior-internal-pelvic-fixator-infix
#7
Rahul Vaidya, Adam Jonathan Martin, Matthew Roth, Frederick Tonnos, Bryant Oliphant, Jon Carlson
OBJECTIVE: To describe our experience using the anterior internal pelvic fixator (INIFX) for treating pelvic ring injuries. DESIGN: Case Series SETTING:: Level 1 Trauma Center PATIENTS:: Eighty-three patients with pelvic ring injuries treated with INFIX. Follow up avg. 35 months (range 12-80.33) INTERVENTION:: Surgical treatment of pelvic ring injuries included reduction, appropriate posterior fixation, and INFIX placement. OUTCOME MEASUREMENTS: Reduction using the pelvic deformity index (PDI) and pubic symphysis(PS) widening, Majeed functional scores, complications; infection, implant failure, heterotopic ossification (HO), nerve injury, and pain...
January 5, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28070599/organophosphate-neurotoxicity-to-the-voluntary-motor-system-on-the-trail-of-environment-caused-amyotrophic-lateral-sclerosis-the-known-the-misknown-and-the-unknown
#8
Samantha J Merwin, Teresa Obis, Yanelli Nunez, Diane B Re
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder. It is characterized by progressive degeneration of the motor neurons controlling voluntary movement. The underlying mechanisms remain elusive, a fact that has precluded development of effective treatments. ALS presents as a sporadic condition 90-95% of the time, i.e., without familial history or obvious genetic mutation. This suggests that ALS has a strong environmental component. Organophosphates (OPs) are prime candidate neurotoxicants in the etiology of ALS, as exposure to OPs was linked to higher ALS incidence among farmers, soccer players, and Gulf War veterans...
January 9, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28062922/interferon-%C3%AE-mediates-human-beta-cell-hla-class-i-overexpression-endoplasmic-reticulum-stress-and-apoptosis-three-hallmarks-of-early-human-type-1-diabetes
#9
Laura Marroqui, Reinaldo S Dos Santos, Anne Op de Beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L Eizirik
AIMS/HYPOTHESIS: Three hallmarks of the pancreatic islets in early human type 1 diabetes are overexpression of HLA class I, endoplasmic reticulum (ER) stress and beta cell apoptosis. The mediators of these phenomena remain to be defined. The type I interferon IFNα is expressed in human islets from type 1 diabetes patients and mediates HLA class I overexpression. We presently evaluated the mechanisms involved in IFNα-induced HLA class I expression in human beta cells and determined whether this cytokine contributes to ER stress and apoptosis...
January 6, 2017: Diabetologia
https://www.readbyqxmd.com/read/28058480/everyman-s-prostate-phantom-kiwi-fruit-substitute-for-human-prostates-at-magnetic-resonance-imaging-diffusion-weighted-imaging-and-magnetic-resonance-spectroscopy
#10
Ullrich G Mueller-Lisse, Sophie Murer, Ulrike L Mueller-Lisse, Marissa Kuhn, Juergen Scheidler, Michael Scherr
OBJECTIVES: To apply an easy-to-assemble phantom substitute for human prostates in T2-weighted magnetic resonance imaging (T2WI), diffusion-weighted imaging (DWI) and 3D magnetic resonance spectroscopy (MRS). METHODS: Kiwi fruit were fixed with gel hot and cold compress packs on two plastic nursery pots, separated by a plastic plate, and submerged in tap water inside a 1-L open-spout plastic watering can for T2WI (TR/TE 7500/101 ms), DWI (5500/61 ms, ADC b50-800 s/mm(2) map) and MRS (940/145 ms) at 3...
January 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28054773/reactivity-of-elemental-tin-and-zinc-toward-organophosphonic-acid-dialkyl-esters-a-new-one-pot-recipe-for-the-synthesis-of-coordination-assemblies-derived-from-o-alkylorganophosphonate-ligands
#11
Ravi Shankar, Swati Mendiratta, Nisha Singla, Gabriele Kociok-Köhn, Michael Lutter, Klaus Jurkschat
A new recipe for the synthesis of diorganotin bis(O-alkylorganophosphonate)s, R(1)2Sn{O(P)(O)(OR(1))R}2 [R = R(1) = methyl (1); R(1) = ethyl and R = methyl (2), allyl (3), 2-thienyl (4), benzyl (5)], has been developed from the direct reaction of elemental tin (powder) with organophosphonic acid dialkyl esters, RP(O)(OR(1))2, in the presence of a catalytic amount of potassium iodide under ambient conditions (130 °C, 18-20 h). The key steps in the proposed catalytic cycle involve the monodealkylation of phosphonate diester and in situ generation of a R(1)SnI or R(1)2SnI2 intermediate via the oxidative addition of alkyl iodide on tin...
January 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28054688/oh-production-from-the-photolysis-of-isoprene-derived-peroxy-radicals-cross-sections-quantum-yields-and-atmospheric-implications
#12
Robert F Hansen, Tom R Lewis, Lee Graham, Lisa K Whalley, Paul W Seakins, Dwayne E Heard, Mark A Blitz
In environments with high concentrations of biogenic volatile organic compounds and low concentrations of nitrogen oxides (NOx = NO + NO2), significant discrepancies have been found between measured and modeled concentrations of hydroxyl radical (OH). The photolysis of peroxy radicals from isoprene (HO-Iso-O2) in the near ultraviolet represents a potential source of OH in these environments, yet has not been considered in atmospheric models. This paper presents measurements of the absorption cross-sections for OH formation (σRO2,OH) from the photolysis of HO-Iso-O2 at wavelengths from 310-362...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28054137/-local-treatment-of-solitary-intrapulmonary-malignant-nodules
#13
J Op den Winkel, F Eichhorn, S Rieken, H Dienemann
DEFINITION: Intrapulmonary nodules generally represent an incidental finding in the roentgenogram or computed tomography (CT) scan of the chest. They are defined as single, well-circumscribed, radiographic opaque lesions that measures up to 3 cm in diameter and are surrounded completely by aerated lung. The probability of malignancy directly correlates with increasing diameter. Lesions that have a diameter of 1 cm or larger require direct evaluation. THERAPY: Surgery is the first option for patients with a malignant lesion, given an acceptable perioperative risk; for high-risk patients either radiofrequency ablation (RFA) or stereotactic body radiation therapy (SBRT) should be offered...
January 4, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28053383/retrospective-study-of-asymmetric-vs-symmetric-tibial-plates-and-ultracongruent-vs-posterior-stabilized-inserts-in-indian-population-an-indian-experience-of-natural-knee-ii
#14
Ajay Deep Singh
BACKGROUND: Results of asymmetric tibial base plates vs symmetric tibial base plates and ultracongruent insert vs posterior stabilized insert in Indian population. METHODS: A total of 47 knee replacements with mean age of 65.2 years in 38 patients (16 males and 22 females) between 2007-2011 were included. Natural Knee II (21 models) were compared with 26 models of other knees (12 PFC-Sigma, one PFC-RPF, 10 Nexgen and three Vanguard). RESULTS: The ultracongruent insert of NK II lead to creation of greater post-op mean flexion deformity of 18° (range 15-20°) as compared to 5...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28051312/modification-of-tio2-nanoparticles-with-oleyl-phosphate-via-phase-transfer-in-the-toluene-water-system-and-application-of-modified-nanoparticles-to-cyclo-olefin-polymer-based-organic-inorganic-hybrid-films-exhibiting-high-refractive-indices
#15
Shiori Takahashi, Shuhei Hotta, Akira Watanabe, Naokazu Idota, Kimihiro Matsukawa, Yoshiyuki Sugahara
Oleyl-phosphate-modified TiO2 nanoparticles (OP_TiO2) were prepared via phase transfer from an aqueous phase containing dispersed TiO2 nanoparticles to a toluene phase containing oleyl phosphate (OP, a mixture of monoester and diester), and employed for the preparation of OP_TiO2/cyclo-olefin polymer (COP) hybrid films with high-refractive indices. The modification of TiO2 by OP was essentially completed by reaction at room temperature for 8 h, and essentially all the TiO2 nanoparticles in the aqueous phase were transferred to the toluene phase...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050455/outcomes-of-short-segment-posterior-instrumentation-in-unstable-thoracolumbar-fractures
#16
Sharvil H Gajjar, Hari J Menon, Nitin Chaudhari, Vipul Chaudhari
INTRODUCTION: The spinal traumas are common and leading problem in orthopaedics practice. The individuals are at a risk of high energy trauma in modern era. Unstable thoracolumbar burst fractures are serious injuries of concern, if left untreated may result in marked morbidity and disability to the patient. Thoracolumbar is the second most common segment involved in the spinal cord following spinal injuries followed by cervical segment. The goal of treatment of any spinal injury is restoration of the patient to maximum possible function with disability free life...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048245/su-f-j-157-effect-of-contouring-uncertainty-in-post-implant-dosimetry-of-low-dose-rate-prostate-permanent-seed-brachytherapy
#17
S Mashouf, H Safigholi, T Merino, A Soliman, A Ravi, G Morton, W Song
PURPOSE: There is strong evidence relating post-implant dosimetry for low-dose-rate (LDR) prostate seed brachytherapy to local control rates. The delineation of the prostate on CT images, however, represents a challenge due to the lack of soft tissue contrast in order to identify the prostate borders. This study aims at quantifying the sensitivity of clinically relevant dosimetric parameters to uncertainty in the contouring of prostate. METHODS: CT images, post-op plans and contours of a cohort of patients (n=43) (low risk=55...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046407/su-f-t-521-flattening-filter-free-beam-parameters-comparison-from-different-linac-machine-types
#18
A Hussain
PURPOSE: Novel linac machines, TrueBeam (TB) and Elekta Versa have updated head designing and software control system, include flattening-filter-free (FFF) photon and electron beams. Later on FFF beams were also introduced on C-Series machines. In this work FFF beams for same energy 6MV but from different machine versions were studied with reference to beam data parameters. METHODS: The 6MV-FFF percent depth doses, profile symmetry and flatness, dose rate tables, and multi-leaf collimator (MLC) transmission factors were measured during commissioning process of both C-series and Truebeam machines...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040942/an-ultra-low-noise-high-voltage-piezo-driver
#19
N C Pisenti, A Restelli, B J Reschovsky, D S Barker, G K Campbell
We present an ultra-low noise, high-voltage driver suited for use with piezoelectric actuators and other low-current applications. The architecture uses a flyback switching regulator to generate up to 250 V in our current design, with an output of 1 kV or more possible with small modifications. A high slew-rate op-amp suppresses the residual switching noise, yielding a total root-mean-square noise of ≈100 μV (1 Hz-100 kHz). A low-voltage (±10 V), high bandwidth signal can be summed with unity gain directly onto the output, making the driver well-suited for closed-loop feedback applications...
December 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28033000/structure-and-bonding-investigation-of-plutonium-peroxocarbonate-complexes-using-cerium-surrogates-and-electronic-structure-modeling
#20
Lucas E Sweet, Jordan F Corbey, Frédéric Gendron, Jochen Autschbach, Bruce K McNamara, Kate L Ziegelgruber, Leah M Arrigo, Shane M Peper, Jon M Schwantes
Herein, we report the synthesis and structural characterization of K8[(CO3)3Pu]2(μ-η(2)-η(2)-O2)2·12H2O. This is the second Pu-containing addition to the previously studied alkali-metal peroxocarbonate series M8[(CO3)3A]2(μ-η(2)-η(2)-O2)2·xH2O (M = alkali metal; A = Ce or Pu; x = 8, 10, 12, or 18), for which only the M = Na analogue has been previously reported when A = Pu. The previously reported crystal structure for Na8[(CO3)3Pu]2(μ-η(2)-η(2)-O2)2·12H2O is not isomorphous with its known Ce analogue...
December 29, 2016: Inorganic Chemistry
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