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https://www.readbyqxmd.com/read/28229021/the-preventive-effect-of-dexmedetomidine-on-paroxysmal-sympathetic-hyperactivity-in-severe-traumatic-brain-injury-patients-who-have-undergone-surgery-a-retrospective-study
#1
Qilin Tang, Xiang Wu, Weiji Weng, Hongpeng Li, Junfeng Feng, Qing Mao, Guoyi Gao, Jiyao Jiang
BACKGROUND: Paroxysmal sympathetic hyperactivity (PSH) results and aggravates in secondary brain injury, which seriously affects the prognosis of severe traumatic brain injury patients. Although several studies have focused on the treatment of PSH, few have concentrated on its prevention. METHODS: Ninety post-operation (post-op) severe traumatic brain injury (sTBI) patients admitted from October 2014 to April 2016 were chosen to participate in this study. Fifty of the post-op sTBI patients were sedated with dexmedetomidine and were referred as the "dexmedetomidine group" (admitted from May 2015 to April 2016)...
2017: PeerJ
https://www.readbyqxmd.com/read/28222678/tracheal-extubation-in-deeply-anesthetized-pediatric-patients-after-tonsillectomy-a-comparison-of-high-concentration-sevoflurane-alone-and-low-concentration-sevoflurane-in-combination-with-dexmedetomidine-pre-medication
#2
Meiqin Di, Yuan Han, Zhuqing Yang, Huacheng Liu, Xuefei Ye, Hongyan Lai, Jun Li, Wangning ShangGuan, Qingquan Lian
BACKGROUND: Dexmedetomidine can facilitate a smooth extubation process and reduce the requirement of sevoflurane and emergence agitation when administrated perioperatively. We aimed to observe the extubation process and the recovery characteristics in pediatric patients undergoing tonsillectomy while anesthetized with either high-concentration sevoflurane alone or low-concentration sevoflurane combined with pre-medication of single dose of intravenous dexmedetomidine. METHODS: Seventy-five patients (ASA I or II, aged 3-7 years) undergoing tonsillectomy were randomized into three equal groups: to receive intravenous saline (Group D0), dexmedetomidine 1 μg/kg (Group D1), or dexmedetomidine 2 μg/kg (Group D2) approximately 10 min before anesthesia...
February 21, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28221154/prospective-outcomes-of-11-13ch-ultra-mini-percutaneous-nephrolithotomy-ump-a-consecutive-cohort-study
#3
Janak D Desai
: Ultra mini PCNL (UMP) has been described as a less invasive technique of PCNL for the treatment of small to medium sized stones in attempt to reduce the surgical morbidity. OBJECTIVE: Evaluate prospectively the outcomes of UMP. METHODS: Single surgeon prospective concurrent cohort study of UMP in India. Effectiveness was assessed by stone-free rates, operative time, complications including transfusion, sepsis rates, length of stay and analgesic requirements...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28208806/orange-pomace-improves-postprandial-glycemic-responses-an-acute-randomized-placebo-controlled-double-blind-crossover-trial-in-overweight-men
#4
C-Y Oliver Chen, Helen Rasmussen, Alison Kamil, Peng Du, Jeffrey B Blumberg
Orange pomace (OP), a fiber-rich byproduct of juice production, has the potential for being formulated into a variety of food products. We hypothesized that OP would diminish postprandial glycemic responses to a high carbohydrate/fat breakfast and lunch. We conducted an acute, randomized, placebo-controlled, double blind, crossover trial with 34 overweight men who consumed either a 255 g placebo (PLA), a low (35% OP (LOP)), or a high (77% (HOP)) dose OP beverage with breakfast. Blood was collected at 0, 10, 20, 30, and 45 min and at 1, 1...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28204811/isopsoralen-mediated-suppression-of-bone-marrow-adiposity-and-attenuation-of-the-adipogenic-commitment-of-bone-marrow-derived-mesenchymal-stem-cells
#5
Jian Wang, Sheng-Fa Li, Ting Wang, Chun-Han Sun, Liang Wang, Min-Jun Huang, Jian Chen, Shao-Wei Zheng, Nan Wang, Ying-Jun Zhang, Tian-Yu Chen
Osteoporosis (OP) increases the risk of bone fractures and other complications, and is thus a major clinical problem. In this study, we examined the effect of isopsoralen on the differentiation of bone-derived marrow mesenchymal stem cells (BMSCs) into osteoblasts and adipocytes, as well as bone formation under osteoporotic conditions. Primary femoral BMSCs isolated from C57BL/6 mice were used to evaluate the isopsoralen-mediated regulation of the expression of alkaline phosphatase (ALP), osteocalcin (OCN) and runt-related transcription factor 2 (RUNX2) during osteogenesis 2 weeks...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28203561/comparative-prospective-case-control-study-of-open-versus-laparoscopic-pyeloplasty-in-children-with-ureteropelvic-junction-obstruction-long-term-results
#6
Lisandro A Piaggio, Juan P Corbetta, Santiago Weller, Ricardo Augusto Dingevan, Víctor Duran, Javier Ruiz, Juan C Lopez
INTRODUCTION: We compare open pyeloplasty (OP) versus laparoscopic pyeloplasty (LP) in children in a multicenter, prospective, case-control study. MATERIALS AND METHODS: From May 2007 to March 2009, a program was established at Hospital Garrahan, the reference center, to perform LP with a mentoring surgeon that would attend the institution once a month. Every new case of ureteropelvic junction obstruction (UPJO) diagnosed in the reference institution was offered to participate in the study...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28202082/bone-morphogenetic-proteins-and-myostatin-pathways-key-mediator-of-human-sarcopenia
#7
Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino
BACKGROUND: Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28199397/efficacy-and-safety-of-preoperative-iop-reduction-using-a-preservative-free-fixed-combination-of-dorzolamide-timolol-eye-drops-versus-oral-acetazolamide-and-dexamethasone-eye-drops-and-assessment-of-the-clinical-outcome-of-trabeculectomy-in-glaucoma
#8
Katrin Lorenz, Joanna Wasielica-Poslednik, Katharina Bell, Giulia Renieri, Alexander Keicher, Christian Ruckes, Norbert Pfeiffer, Hagen Thieme
INTRODUCTION: To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients. MATERIALS AND METHODS: Sixty-two eyes undergoing trabeculectomy with mitomycin C were included in this monocentric prospective randomized controlled study. IOP change between baseline and 3 months post-op was defined as the primary efficacy variable...
2017: PloS One
https://www.readbyqxmd.com/read/28187825/characterization-of-acetylcholinesterase-from-elm-left-beetle-xanthogaleruca-luteola-and-qsar-of-temephos-derivatives-against-its-activity
#9
Mahboobeh Sharifi, Mohammad Ghadamyari, Khodayar Gholivand, Ali Asghar Ebrahimi Valmoozi, Reza H Sajedi
Insect acetylcholinesterase (AChE) is the principal target for organophosphate (OP) and carbamate (CB) insecticides. In this research, an AChE from third instar larvae of elm left beetle, Xanthogaleruca luteola was purified by affinity chromatography. The enzyme was purified 75.29-fold with a total yield of 8.51%. As shown on denaturing SDS-PAGE, the molecular mass of purified AChE was 70kDa. The enzyme demonstrated maximum activity at pH7 and 35°C. Furthermore, a series of temephos (Tem) derivatives with the general structure of P(O)XP(O) (1-44) were prepared, synthesized and characterized by (31)P, (13)C, (1)H NMR and FT-IR spectral techniques...
March 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28187347/influence-of-blooms-of-phytoplankton-on-concentrations-of-hydrophobic-organic-chemicals-in-sediments-and-snails-in-a-hyper-eutrophic-freshwater-lake
#10
Wei Shi, Nanyang Yu, Xia Jiang, Zhihua Han, Shuhang Wang, Xiaowei Zhang, Si Wei, John P Giesy, Hongxia Yu
Blooms of phytoplankton, which are common in freshwater ecosystems, might not only affect quality of water but also influence biogeochemical processing of pollutants. Based on three years of field observations in sediments of Tai Lake, China, concentrations of organochlorine (OC) pesticides and polycyclic aromatic hydrocarbons (PAHs) in areas where blooms occurred were 2.4 and 3.4 times greater than concentrations in areas without blooms. Concentrations of octylphenol (OP), nonylphenol (NP) and bisphenol A (BPA) in areas where blooms did not occur were 3...
January 31, 2017: Water Research
https://www.readbyqxmd.com/read/28161867/towards-understanding-the-catalytic-mechanism-of-human-paraoxonase-1-experimental-and-in-silico-mutagenesis-studies
#11
Rajan K Tripathy, Geetika Aggarwal, Priyanka Bajaj, Deepika Kathuria, Prasad V Bharatam, Abhay H Pande
Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. It is a potential candidate for the development of antidote against OP poisoning in humans. However, insufficient OP-hydrolyzing activity of native enzyme affirms the urgent need to develop improved variant(s) having enhanced OP-hydrolyzing activity. The crystal structure of h-PON1 remains unsolved, and the molecular details of how the enzyme catalyses hydrolysis of different types of substrates are also not clear...
February 4, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28156579/snapshot-of-an-outpatient-supportive-care-center-at-a-comprehensive-cancer-center
#12
Maxine Grace De la Cruz, Angelique Wong, Debra Castro, Eduardo Bruera
: 145 Background: Integration of Palliative Care (PC) in oncology has been found to improve symptom distress, quality of life and survival in patients with advanced cancer. Early integration is most appropriate in the outpatient (OP) setting. However, most PC services in the U.S. do not have an OP component. Our study aims to provide a snapshot of the type of patients that are referred to this novel setting for the delivery of early PC. METHODS: We reviewed a day in the SCC to illustrate the structure and process involved in the delivery of outpatient PC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156447/practice-patterns-and-outcomes-of-rivaroxaban-usage-in-patients-with-cancer
#13
Ali Zalpour, Juhee Song, Marsha N Richardson, Tony Lam, Josiah Halm, SWamique Yusuf, Shuwei Gao
: 194 Background: Patients with cancer have an increased risk of venous thromboembolism (VTE) and frequently require anticoagulation. In addition, many patients with cancer also have comorbidities such as atrial fibrillation (AF) and are on stroke prevention. Rivaroxaban (RV) is an oral (factor Xa inhibitor) used in these scenarios; however, there is little experience utilizing this agent in patients with cancer. Our aim is to describe practice patterns and outcomes of RV usage in patients with cancer...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153602/comparison-of-allograft-and-polyetheretherketone-peek-cage-subsidence-rates-in-anterior-cervical-discectomy-and-fusion-acdf
#14
Sharon C Yson, Jonathan N Sembrano, Edward Rainier G Santos
Structural allografts and PEEK cages are commonly used interbody fusion devices in ACDF. The subsidence rates of these two spacers have not yet been directly compared. The primary aim of this study was to compare the subsidence rate of allograft and PEEK cage in ACDF. The secondary aim was to determine if the presence of subsidence affects the clinical outcome. We reviewed 67 cases (117 levels) of ACDF with either structural allograft or PEEK cages. There were 85 levels (48 cases) with PEEK and 32 levels (19 cases) with allograft spacers...
January 30, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28152819/electronic-operative-reports-to-support-quality-improvement-and-patient-centered-care
#15
Elaine Maloney, Mary Agent-Katwala, Geoff Porter
: 95 Background: Operative reports (OP) for cancer surgery are usually narrated, although they provide inconsistent and incomplete information for patient care. National standards for cancer OP were unavailable until 2007. Over 10 years, surgeons in four Canadian provinces have transitioned from narrative to electronic synoptic reporting (ESP) for specific cancers. The electronic OP are now considered a patient medical record and integral to subsequent patient care. Surgeons are using electronic reports for quality assurance, billing, medical-legal conflict resolution and research...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28147699/note-a-high-performance-low-cost-laser-shutter-using-a-piezoelectric-cantilever-actuator
#16
W Bowden, I R Hill, P E G Baird, P Gill
We report the design and characterization of an optical shutter based on a piezoelectric cantilever. Compared to conventional electro-magnetic shutters, the device has intrinsically low power and is acoustically quiet. The cantilever position is controlled by a high-voltage op-amp circuit for easy tuning of the range of travel, and mechanical slew rate, which enables a factor of 30 reduction in mechanical noise compared to a rapidly switched device. We achieve shuttering rise and fall times of 11 μs, corresponding to mechanical slew rates of 1...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28146009/automatic-cochlear-duct-length-estimation-for-selection-of-cochlear-implant-electrode-arrays
#17
Alejandro Rivas, Ahmet Cakir, Jacob B Hunter, Robert F Labadie, M Geraldine Zuniga, George B Wanna, Benoit M Dawant, Jack H Noble
HYPOTHESIS: Cochlear duct length (CDL) can be automatically measured for custom selection of cochlear implant (CI) electrode arrays. BACKGROUND: CI electrode array selection can be influenced by measuring the CDL, which is estimated based on the length of the line that connects the round window and the lateral wall of the cochlea when passing through the modiolus. CDL measurement remains time consuming and inter-observer variability has not been studied. METHODS: We evaluate an automatic approach to directly measure the two-turn (2T) CDL using existing algorithms for localizing cochlear anatomy in computed tomography (CT)...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28132851/patient-reported-social-psychological-and-urologic-outcomes-after-adult-buried-penis-repair
#18
Maria A Voznesensky, W Thomas Lawrence, Jerrod N Keith, Bradley A Erickson
OBJECTIVE: To assess changes in hygiene, urination, and sexual activity after surgery for adult-acquired buried penis. MATERIALS AND METHODS: The study included men who underwent buried penis repair from 2011 to 2015. Patients were asked pre- and postoperative questions on hygiene, urinary difficulties, sexual difficulties, and difficulties with activities of daily living (modified Post-Bariatric Surgery Quality of Life Questionnaire). Postoperative satisfaction was assessed at a minimum of 6 months...
January 26, 2017: Urology
https://www.readbyqxmd.com/read/28127175/management-of-bilateral-wilms-tumor-our-experience
#19
Raghunath Bv, Vinay Jadhav, Gowri Shankar, Narendrababu M, Ramesh S
Management of bilateral Wilms' tumor is particularly challenging, considering the chances of recurrence and long-term renal function for affected patients. Aggressive surgical resection to prevent recurrence must be balanced with the desire to preserve renal function. We evaluated our experience in the management of bilateral Wilms' tumor stressing the challenges encountered in decision making and the role of nephron sparing surgery. We had four children presenting with bilateral Wilms' tumor. All of them were appropriately staged and given standard chemotherapy as per NWTS-5 guidelines...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28124380/methylated-free-circulating-hpp1-dna-is-an-early-response-marker-in-patients-with-metastatic-colorectal-cancer
#20
Andreas Herbst, Nikolay Vdovin, Sanja Gacesa, Alexander Philipp, Dorothea Nagel, Lesca M Holdt, Mark Op den Winkel, Volker Heinemann, Petra Stieber, Ullrich Graeven, Anke Reinacher-Schick, Dirk Arnold, Ingrid Ricard, Ulrich Mansmann, Susanna Hegewisch-Becker, Frank T Kolligs
Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimidine, oxaliplatin and bevacizumab to test whether HPP1 mfcDNA is a suitable prognostic and response biomarker. From 467 patients of the prospective clinical study AIO-KRK-0207, mfcDNA was isolated from plasma samples at different time points and bisulfite-treated mfcDNA was quantified using methylation specific PCR...
January 25, 2017: International Journal of Cancer. Journal International du Cancer
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