keyword
https://read.qxmd.com/read/38259228/patient-privacy-and-data-provenance-in-pulmonary-and-critical-care-research-using-big-data
#21
JOURNAL ARTICLE
Snigdha Jain, Harlan M Krumholz
No abstract text is available yet for this article.
January 23, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38259170/-methylocystis-suflitae-sp-nov-a-novel-type-ii-methanotrophic-bacterium-isolated-from-landfill-cover-soil
#22
JOURNAL ARTICLE
Christopher T Garner, Krithivasan Sankaranarayanan, Christopher A Abin, Rosa M Garner, Haiyuan Cai, Paul A Lawson, Lee R Krumholz
A bacterial strain, designated NLS-7T , was isolated through enrichment of landfill cover soil in methane-oxidizing conditions. Strain NLS-7T is a Gram-stain negative, non-motile rod, approximately 0.8 µm wide by 1.3 µm long. Phylogenetic analysis based on 16S rRNA gene sequencing places it within the genus Methylocystis , with its closest relatives being M. hirsuta , M. silviterrae and M. rosea , with 99.9, 99.7 and 99.6 % sequence similarity respectively. However, average nucleotide identity and average amino acid identity values below the 95 % threshold compared to all the close relatives and digital DNA-DNA hybridization values between 20...
January 2024: International Journal of Systematic and Evolutionary Microbiology
https://read.qxmd.com/read/38234746/identification-of-hypertrophic-cardiomyopathy-on-electrocardiographic-images-with-deep-learning
#23
Veer Sangha, Lovedeep Singh Dhingra, Evangelos Oikonomou, Arya Aminorroaya, Nikhil V Sikand, Sounok Sen, Harlan M Krumholz, Rohan Khera
BACKGROUND: Hypertrophic cardiomyopathy (HCM) affects 1 in every 200 individuals and is the leading cause of sudden cardiac death in young adults. HCM can be identified using an electrocardiogram (ECG) raw voltage data and deep learning approaches, but their point-of-care application is limited by the inaccessibility of these signal data. We developed a deep learning-based approach that overcomes this limitation and detects HCM from images of 12-lead ECGs across layouts. METHODS: We identified ECGs from patients with HCM features present on cardiac magnetic resonance imaging (CMR) or those within 30 days of an echocardiogram documenting thickened interventricular septum (end-diastolic interventricular septum thickness > 15mm)...
December 28, 2023: medRxiv
https://read.qxmd.com/read/38233019/when-direct-oral-anticoagulants-should-not-be-standard-treatment-jacc-state-of-the-art-review
#24
REVIEW
Antoine Bejjani, Candrika D Khairani, Ali Assi, Gregory Piazza, Parham Sadeghipour, Azita H Talasaz, John Fanikos, Jean M Connors, Deborah M Siegal, Geoffrey D Barnes, Karlyn A Martin, Dominick J Angiolillo, Dawn Kleindorfer, Manuel Monreal, David Jimenez, Saskia Middeldorp, Mitchell S V Elkind, Christian T Ruff, Samuel Z Goldhaber, Harlan M Krumholz, Roxana Mehran, Mary Cushman, John W Eikelboom, Gregory Y H Lip, Jeffrey I Weitz, Renato D Lopes, Behnood Bikdeli
For most patients, direct oral anticoagulants (DOACs) are preferred over vitamin K antagonists for stroke prevention in atrial fibrillation and for venous thromboembolism treatment. However, randomized controlled trials suggest that DOACs may not be as efficacious or as safe as the current standard of care in conditions such as mechanical heart valves, thrombotic antiphospholipid syndrome, and atrial fibrillation associated with rheumatic heart disease. DOACs do not provide a net benefit in conditions such as embolic stroke of undetermined source...
January 23, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38226473/transformational-journey-of-outcomes-research-looking-back-from-the-future
#25
JOURNAL ARTICLE
Harlan M Krumholz
No abstract text is available yet for this article.
January 2024: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/38213879/patterns-of-digoxin-prescribing-for-medicare-beneficiaries-in-the-united-states-2013-2019
#26
JOURNAL ARTICLE
Claudia See, Kevin M Wheelock, César Caraballo, Rohan Khera, Amarnath Annapureddy, Shiwani Mahajan, Yuan Lu, Harlan M Krumholz, Karthik Murugiah
BACKGROUND: Studies show that digoxin use is declining but is still prevalent. Recent data on digoxin prescription and characteristics of digoxin prescribers are unknown, which can help understand its contemporary use. METHODS: Using Medicare Part D data from 2013 to 2019, we studied the change in number and proportion of digoxin prescriptions and digoxin prescribers, overall and by specialty. Using logistic regression, we identified prescriber characteristics associated with digoxin prescription...
December 2023: Am J Med Open
https://read.qxmd.com/read/38207039/illusory-generalizability-of-clinical-prediction-models
#27
JOURNAL ARTICLE
Adam M Chekroud, Matt Hawrilenko, Hieronimus Loho, Julia Bondar, Ralitza Gueorguieva, Alkomiet Hasan, Joseph Kambeitz, Philip R Corlett, Nikolaos Koutsouleris, Harlan M Krumholz, John H Krystal, Martin Paulus
It is widely hoped that statistical models can improve decision-making related to medical treatments. Because of the cost and scarcity of medical outcomes data, this hope is typically based on investigators observing a model's success in one or two datasets or clinical contexts. We scrutinized this optimism by examining how well a machine learning model performed across several independent clinical trials of antipsychotic medication for schizophrenia. Models predicted patient outcomes with high accuracy within the trial in which the model was developed but performed no better than chance when applied out-of-sample...
January 12, 2024: Science
https://read.qxmd.com/read/38190959/racial-ethnic-disparities-in-aortic-valve-replacement-among-medicare-beneficiaries-in-the-united-states-2012-2019
#28
JOURNAL ARTICLE
Aakriti Gupta, Makoto Mori, Yun Wang, Shubhadarshini G Pawar, Torsten Vahl, Tamim Nazif, Oyere Onuma, Celina M Yong, Rahul Sharma, Ajay J Kirtane, John K Forrest, Isaac George, Susheel Kodali, Joanna Chikwe, Arnar Geirsson, Raj Makkar, Martin B Leon, Harlan M Krumholz
PURPOSE: There are concerns that transcatheter or surgical aortic valve replacement (TAVR/SAVR) procedures are preferentially available to White patients. OBJECTIVE: Our objective was to examine differences in utilization of aortic valve replacement and outcomes by race/ethnicity in the US for patients with aortic stenosis. METHODS: We performed a serial cross-sectional cohort study of 299,976 Medicare beneficiaries hospitalized with principal diagnosis of aortic stenosis between 2012 and 2019 stratified by self-reported race/ethnicity (Black, Hispanic, Asian, Native American, and White)...
January 6, 2024: American Journal of Medicine
https://read.qxmd.com/read/38176425/developmental-or-procedural-vena-cava-interruption-and-venous-thromboembolism-a-review
#29
JOURNAL ARTICLE
Behnood Bikdeli, Parham Sadeghipour, Junyang Lou, Antoine Bejjani, Candrika D Khairani, Sina Rashedi, Robert Lookstein, Alexandra Lansky, Suresh Vedantham, Piotr Sobieszczyk, Carlos Mena-Hurtado, Ayaz Aghayev, Peter Henke, Ghazaleh Mehdipoor, Antonella Tufano, Saurav Chatterjee, Saskia Middeldorp, Suman Wasan, Riyaz Bashir, Irene M Lang, Mehdi H Shishehbor, Marie Gerhard-Herman, Jay Giri, Matthew T Menard, Sahil A Parikh, Lucia Mazzolai, Lisa Moores, Manuel Monreal, David Jimenez, Samuel Z Goldhaber, Harlan M Krumholz, Gregory Piazza
The inferior vena cava (IVC) and superior vena cava are the main conduits of the systemic venous circulation into the right atrium. Developmental or procedural interruptions of vena cava might predispose to stasis and deep vein thrombosis (DVT) distal to the anomaly and may impact the subsequent rate of pulmonary embolism (PE). This study aimed to review the various etiologies of developmental or procedural vena cava interruption and their impact on venous thromboembolism. A systematic search was performed in PubMed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines per each clinical question...
January 4, 2024: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/38154880/characterisation-of-internal-tremors-and-vibration-symptoms
#30
JOURNAL ARTICLE
Dorothy Massey, Mitsuaki Sawano, Anna D Baker, Diana Berrent Güthe, Nick Güthe, Suzanne Pincus Shidlovsky, Liza Fisher, Connor B Grady, Cesar Caraballo, Tianna Zhou, Richa Sharma, Harlan M Krumholz
OBJECTIVES: To describe the experiences of patients who have postacute sequelae SARS-CoV-2 infection with internal vibrations and tremors as a prominent component, we leveraged the efforts by Survivor Corps, a grassroots COVID-19 patient advocacy group, to gather information from individuals belonging to its Facebook group with a history of COVID-19 suffering from vibrations and tremors. SETTING AND DESIGN: A narrative analysis was performed on 140 emails and 450 social media comments from 140 individuals collected as a response to a call to >180 000 individuals participating in Survivor Corps between 15 July and 27 July 2021...
December 28, 2023: BMJ Open
https://read.qxmd.com/read/38117492/use-of-open-science-practices-in-surgical-journals
#31
JOURNAL ARTICLE
Kavya Pathak, Jayson S Marwaha, Hao Wei Chen, Harlan M Krumholz, Jeffrey B Matthews
No abstract text is available yet for this article.
December 20, 2023: JAMA Surgery
https://read.qxmd.com/read/38094515/use-of-smart-devices-to-track-cardiovascular-health-goals-in-the-united-states
#32
JOURNAL ARTICLE
Arya Aminorroaya, Lovedeep S Dhingra, Arash A Nargesi, Evangelos K Oikonomou, Harlan M Krumholz, Rohan Khera
BACKGROUND: Smartphone-based health applications are increasingly popular, but their real-world use for cardiovascular risk management remains poorly understood. OBJECTIVES: The purpose of this study was to investigate the patterns of tracking health goals using smart devices, including smartphones and/or tablets, in the United States. METHODS: Using the nationally representative Health Information National Trends Survey for 2017 to 2020, we examined self-reported tracking of health-related goals (optimizing body weight, increasing physical activity, and/or quitting smoking) using smart devices among those with cardiovascular disease (CVD) or cardiovascular risk factors of hypertension, diabetes, obesity, and/or smoking...
September 2023: JACC Adv
https://read.qxmd.com/read/38093182/prevalence-of-covid-19-and-long-covid-in-collegiate-student-athletes-from-spring-2020-to-fall-2021-a-retrospective-survey
#33
JOURNAL ARTICLE
Daisy Massey, Sharon Saydah, Blythe Adamson, Andrew Lincoln, Douglas F Aukerman, Ethan M Berke, Robby Sikka, Harlan M Krumholz
BACKGROUND: Symptomatic COVID-19 and Long COVID, also referred to as post-acute sequelae of SARS-CoV-2 (PASC) or post-COVID conditions, have been widely reported in young, healthy people, but their prevalence has not yet been determined in student athletes. We sought to estimate the prevalence of reported COVID-19, symptomatic COVID-19, and Long COVID in college athletes in the United States attending 18 schools from spring 2020 to fall 2021. METHODS: We developed an online survey to measure the prevalence of student athletes who tested positive for COVID-19, developed Long COVID, and did not return to their sport during the relevant time period...
December 13, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/38088608/supreme-court-impacts-in-public-health-law-2022-2023
#34
JOURNAL ARTICLE
James G Hodge, Leila Barraza, Jennifer L Piatt, Erica N White, Summer Ghaith, Samantha Hollinshead, Lauren Krumholz, Madisyn Puchebner, Emma Smith
In another tumultuous term of the United States Supreme Court in 2022-2023 a series of critical cases implicate instant and forthcoming changes in multiple fronts that collectively shift the national public health law and policy environment.
2023: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://read.qxmd.com/read/38050754/association-of-neighborhood-level-marginalization-with-health-care-use-and-clinical-outcomes-following-hospital-discharge-in-patients-who-underwent-coronary-catheterization-for-acute-myocardial-infarction-in-a-single-payer-health-care-system
#35
JOURNAL ARTICLE
Leo E Akioyamen, Husam Abdel-Qadir, Lu Han, Maneesh Sud, Nikhil Mistry, David A Alter, Clare L Atzema, Peter C Austin, R Sacha Bhatia, Gillian L Booth, Irfan Dhalla, Andrew C T Ha, Cynthia A Jackevicius, Moira K Kapral, Harlan M Krumholz, Douglas S Lee, Candace D McNaughton, Idan Roifman, Michael J Schull, Atul Sivaswamy, Karen Tu, Jacob A Udell, Harindra C Wijeysundera, Dennis T Ko
BACKGROUND: Canadian data suggest that patients of lower socioeconomic status with acute myocardial infarction receive less beneficial therapy and have worse clinical outcomes, raising questions regarding care disparities even in universal health care systems. We assessed the contemporary association of marginalization with clinical outcomes and health services use. METHODS: Using clinical and administrative databases in Ontario, Canada, we conducted a population-based study of patients aged ≥65 years hospitalized for their first acute myocardial infarction between April 1, 2010 and March 1, 2019...
December 5, 2023: Circulation. Cardiovascular Quality and Outcomes
https://read.qxmd.com/read/38039001/national-trends-in-racial-and-ethnic-disparities-in-use-of-recommended-therapies-in-adults-with-atherosclerotic-cardiovascular-disease-1999-2020
#36
JOURNAL ARTICLE
Yuan Lu, Yuntian Liu, Lovedeep Singh Dhingra, César Caraballo, Shiwani Mahajan, Daisy Massey, Erica S Spatz, Richa Sharma, Fatima Rodriguez, Karol E Watson, Frederick A Masoudi, Harlan M Krumholz
IMPORTANCE: Despite efforts to improve the quality of care for patients with atherosclerotic cardiovascular disease (ASCVD), it is unclear whether the US has made progress in reducing racial and ethnic differences in utilization of guideline-recommended therapies for secondary prevention. OBJECTIVE: To evaluate 21-year trends in racial and ethnic differences in utilization of guideline-recommended pharmacological medications and lifestyle modifications among US adults with ASCVD...
December 1, 2023: JAMA Network Open
https://read.qxmd.com/read/38015503/race-and-ethnicity-and-emergency-department-discharge-against-medical-advice
#37
JOURNAL ARTICLE
Jennifer W Tsai, Alexander Janke, Harlan M Krumholz, Hazar Khidir, Arjun K Venkatesh
IMPORTANCE: Although discharges against medical advice (DAMA) are associated with greater morbidity and mortality, little is known about current racial and ethnic disparities in DAMA from the emergency department (ED) nationally. OBJECTIVE: To characterize current patterns of racial and ethnic disparities in rates of ED DAMA. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the Nationwide Emergency Department Sample on all hospital ED visits made between January to December 2019 in the US...
November 1, 2023: JAMA Network Open
https://read.qxmd.com/read/38001154/an-explainable-machine-learning-based-phenomapping-strategy-for-adaptive-predictive-enrichment-in-randomized-clinical-trials
#38
JOURNAL ARTICLE
Evangelos K Oikonomou, Phyllis M Thangaraj, Deepak L Bhatt, Joseph S Ross, Lawrence H Young, Harlan M Krumholz, Marc A Suchard, Rohan Khera
Randomized clinical trials (RCT) represent the cornerstone of evidence-based medicine but are resource-intensive. We propose and evaluate a machine learning (ML) strategy of adaptive predictive enrichment through computational trial phenomaps to optimize RCT enrollment. In simulated group sequential analyses of two large cardiovascular outcomes RCTs of (1) a therapeutic drug (pioglitazone versus placebo; Insulin Resistance Intervention after Stroke (IRIS) trial), and (2) a disease management strategy (intensive versus standard systolic blood pressure reduction in the Systolic Blood Pressure Intervention Trial (SPRINT)), we constructed dynamic phenotypic representations to infer response profiles during interim analyses and examined their association with study outcomes...
November 25, 2023: NPJ Digital Medicine
https://read.qxmd.com/read/37995937/variation-in-reader-reported-severity-of-paradoxical-low-flow-low-gradient-aortic-stenosis
#39
JOURNAL ARTICLE
Nimish N Shah, Lissa Sugeng, Zhiyuan Zhang, Kangxin Wang, Robert L McNamara, Vratika Agarwal, David J Hur, Bernardo Lombo, Lavanya Bellumkonda, Michael Mankbadi, Abdel Rahman Basem Dajani, John K Forrest, Harlan M Krumholz, Samuel W Reinhardt, Eric J Velazquez, Kamil F Faridi
No abstract text is available yet for this article.
November 21, 2023: Journal of the American Society of Echocardiography
https://read.qxmd.com/read/37986769/post-vaccination-syndrome-a-descriptive-analysis-of-reported-symptoms-and-patient-experiences-after-covid-19-immunization
#40
Harlan M Krumholz, Yilun Wu, Mitsuaki Sawano, Rishi Shah, Tianna Zhou, Adith S Arun, Pavan Khosla, Shayaan Kaleem, Anushree Vashist, Bornali Bhattacharjee, Qinglan Ding, Yuan Lu, César Caraballo, Frederick Warner, Chenxi Huang, Jeph Herrin, David Putrino, Danice Hertz, Brianne Dressen, Akiko Iwasaki
INTRODUCTION: A chronic post-vaccination syndrome (PVS) after covid-19 vaccination has been reported but has yet to be well characterized. METHODS: We included 241 individuals aged 18 and older who self-reported PVS after covid-19 vaccination and who joined the online Yale Listen to Immune, Symptom and Treatment Experiences Now (LISTEN) Study from May 2022 to July 2023. We summarized their demographics, health status, symptoms, treatments tried, and overall experience...
November 10, 2023: medRxiv
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