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https://www.readbyqxmd.com/read/29451557/biomedical-journal-speed-and-efficiency-a-cross-sectional-pilot-survey-of-author-experiences
#1
Joshua D Wallach, Alexander C Egilman, Anand D Gopal, Nishwant Swami, Harlan M Krumholz, Joseph S Ross
Background: Although the peer review process is believed to ensure scientific rigor, enhance research quality, and improve manuscript clarity, many investigators are concerned that the process is too slow, too expensive, too unreliable, and too static. In this feasibility study, we sought to survey corresponding authors of recently published clinical research studies on the speed and efficiency of the publication process. Methods: Web-based survey of corresponding authors of a 20% random sample of clinical research studies in MEDLINE-indexed journals with Ovid MEDLINE entry dates between December 1 and 15, 2016...
2018: Research Integrity and Peer Review
https://www.readbyqxmd.com/read/29450464/evaluating-readmission-need-for-more-clarity-on-methods
#2
Harlan M Krumholz, Kumar Dharmarajan, Sharon-Lise T Normand
No abstract text is available yet for this article.
February 14, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29421010/training-cardiovascular-outcomes-researchers-a-survey-of-mentees-and-mentors-to-identify-critical-training-gaps-and-needs
#3
Prateeti Khazanie, Sana M Al-Khatib, Tracy Y Wang, Matthew J Crowley, Nancy R Kressin, Harlan M Krumholz, Catarina I Kiefe, Barbara L Wells, Sean M O'Brien, Eric D Peterson, Gillian D Sanders
BACKGROUND: Many young investigators are interested in cardiovascular (CV) outcomes research; however, the current training experience of early investigators across the United States is uncertain. METHODS: From April to November 2014, we surveyed mentees and mentors of early-stage CV outcomes investigators across the United States. We contacted successful grantees of government agencies, members of professional organizations, and trainees in CV outcomes training programs...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29421009/how-well-does-early-career-investigators-cardiovascular-outcomes-research-training-align-with-funded-outcomes-research
#4
Matthew J Crowley, Sana M Al-Khatib, Tracy Y Wang, Prateeti Khazanie, Nancy R Kressin, Harlan M Krumholz, Catarina I Kiefe, Barbara L Wells, Sean M O'Brien, Eric D Peterson, Gillian D Sanders
BACKGROUND: Outcomes research training programs should prepare trainees to successfully compete for research funding. We examined how early-career investigators' prior and desired training aligns with recently funded cardiovascular (CV) outcomes research. METHODS: We (1) reviewed literature to identify 13 core competency areas in CV outcomes research; (2) surveyed early-career investigators to understand their prior and desired training in each competency area; (3) examined recently funded grants commonly pursued by early-career outcomes researchers to ascertain available funding in competency areas; and (4) analyzed alignment between investigator training and funded research in each competency area...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29374046/comparison-of-prevalence-awareness-treatment-and-control-of-cardiovascular-risk-factors-in-china-and-the-united-states
#5
Yuan Lu, Pei Wang, Tianna Zhou, Jiapeng Lu, Erica S Spatz, Khurram Nasir, Lixin Jiang, Harlan M Krumholz
BACKGROUND: The reasons for China's high stroke prevalence are not well understood. The cardiovascular risk factor profiles of China and the United States have not been directly compared in nationally representative population samples. METHODS AND RESULTS: Using data from the CHARLS (China Health and Retirement Longitudinal Study) and the NHANES (US National Health and Nutrition Examination Survey), we compared cardiovascular risk factors from 2011 to 2012 among people aged 45 to 75 years between the 2 countries (China, 12 654 people; United States, 2607 people): blood pressure, cholesterol, body mass index, waist circumference, fasting plasma glucose, hemoglobin A1c, and high-sensitivity C-reactive protein...
January 26, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29371221/bringing-vioxx-back-to-market
#6
EDITORIAL
Joseph S Ross, Harlan M Krumholz
No abstract text is available yet for this article.
January 25, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29358195/national-trends-in-nonstatin-use-and-expenditures-among-the-us-adult-population-from-2002-to-2013-insights-from-medical-expenditure-panel%C3%A2-survey
#7
Joseph A Salami, Haider J Warraich, Javier Valero-Elizondo, Erica S Spatz, Nihar R Desai, Jamal S Rana, Salim S Virani, Ron Blankstein, Amit Khera, Michael J Blaha, Roger S Blumenthal, Barry T Katzen, Donald Lloyd-Jones, Harlan M Krumholz, Khurram Nasir
BACKGROUND: Evidence supporting nonstatin lipid-lowering therapy in atherosclerotic cardiovascular disease risk reduction is variable. We aim to examine nonstatin utilization and expenditures in the United States between 2002 and 2013. METHODS AND RESULTS: We used the Medical Expenditure Panel Survey database to estimate national trends in nonstatin use and cost (total and out-of-pocket, adjusted to 2013 US dollars using a gross domestic product deflator) among adults 40 years or older...
January 22, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29340673/risks-of-statins-for-lower-risk-individuals-reply
#8
LETTER
Harlan M Krumholz
No abstract text is available yet for this article.
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29340571/comparison-of-physician-visual-assessment-with-quantitative-coronary-angiography-in-assessment-of-stenosis-severity-in-china
#9
Haibo Zhang, Lin Mu, Shuang Hu, Brahmajee K Nallamothu, Alexandra J Lansky, Bo Xu, Georgios Bouras, David J Cohen, John A Spertus, Frederick A Masoudi, Jeptha P Curtis, Runlin Gao, Junbo Ge, Yuejin Yang, Jing Li, Xi Li, Xin Zheng, Yetong Li, Harlan M Krumholz, Lixin Jiang
Importance: Although physician visual assessment (PVA) of stenosis severity is a standard clinical practice to support decisions for coronary revascularization, there are concerns about its accuracy. Objective: To compare PVA with quantitative coronary angiography (QCA) as a means of assessing stenosis severity among patients undergoing percutaneous coronary intervention (PCI) in China. Design, Setting, and Participants: A cross-sectional study (2012-2013) of a random subset of 1295 patients from the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Prospective PCI Study was carried out...
January 16, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29304541/rationale-design-and-methodology-of-the-computerized-registry-of-patients-with-venous-thromboembolism-riete
#10
Behnood Bikdeli, David Jimenez, Mayra Hawkins, Salvador Ortíz, Paolo Prandoni, Benjamin Brenner, Hervé Decousus, Frederick A Masoudi, Javier Trujillo-Santos, Harlan M Krumholz, Manuel Monreal
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a preventable cause of in-hospital death, and one of the most prevalent vascular diseases. There is a lack of knowledge with regards to contemporary presentation, management and outcomes of patients with VTE. Many clinically important subgroups (including the elderly, those with recent bleeding and pregnant patients) have been under-represented in clinical trials. Furthermore, design of clinical trials is challenging in some scenarios, such as in those with hemodynamically unstable PE...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29295826/blood-pressure-guidelines-as-starting-point-in-clinical-decisions
#11
EDITORIAL
Harlan M Krumholz
No abstract text is available yet for this article.
January 2, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29273661/design-and-rationale-of-the-cardiovascular-health-and-text-messaging-chat-study-and-the-chat-diabetes-mellitus-chat-dm-study-two-randomised-controlled-trials-of-text-messaging-to-improve-secondary-prevention-for-coronary-heart-disease-and-diabetes
#12
Xiqian Huo, Erica S Spatz, Qinglan Ding, Paul Horak, Xin Zheng, Claire Masters, Haibo Zhang, Melinda L Irwin, Xiaofang Yan, Wenchi Guan, Jing Li, Xi Li, John A Spertus, Frederick A Masoudi, Harlan M Krumholz, Lixin Jiang
INTRODUCTION: Mobile health interventions have the potential to promote risk factor management and lifestyle modification, and are a particularly attractive approach for scaling across healthcare systems with limited resources. We are conducting two randomised trials to evaluate the efficacy of text message-based health messages in improving secondary coronary heart disease (CHD) prevention among patients with or without diabetes. METHODS AND ANALYSIS: The Cardiovascular Health And Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study are multicentre, single-blind, randomised controlled trials of text messaging versus standard treatment with 6 months of follow-up conducted in 37 hospitals throughout 17 provinces in China...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29248362/large-scale-epidemiologic-studies-of-cardiovascular-diseases-in-china-need-for-improved-data-collection-methods-transparency-and-documentation
#13
REVIEW
Hui Qu, Yuan Lu, Emily Gudbranson, Emily M Bucholz, Si Xuan, Frederick A Masoudi, John A Spertus, Xin Zheng, Jing Li, Harlan M Krumholz
With the advent of international precision medicine initiatives, it is important to evaluate existing large-scale studies to inform future investigation. This study sought to review, describe, and evaluate all large-scale cardiovascular disease (CVD) studies completed in China. We undertook a review of all large-scale CVD studies completed in China to describe and evaluate their design, implementation, and dissemination in published medical reports. Seventeen studies met the inclusion criteria. There were substantial variations in study design, geographic location, and data collection...
December 13, 2017: Global Heart
https://www.readbyqxmd.com/read/29241491/data-sharing-and-cardiology-platforms-and-possibilities
#14
REVIEW
Pranammya Dey, Joseph S Ross, Jessica D Ritchie, Nihar R Desai, Sanjeev P Bhavnani, Harlan M Krumholz
Sharing deidentified patient-level research data presents immense opportunities to all stakeholders involved in cardiology research and practice. Sharing data encourages the use of existing data for knowledge generation to improve practice, while also allowing for validation of disseminated research. In this review, we discuss key initiatives and platforms that have helped to accelerate progress toward greater sharing of data. These efforts are being prompted by government, universities, philanthropic sponsors of research, major industry players, and collaborations among some of these entities...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29237746/impact-of-telemonitoring-on-health-status
#15
Natalie M Jayaram, Yevgeniy Khariton, Harlan M Krumholz, Sarwat I Chaudhry, Jennifer Mattera, Fengming Tang, Jeph Herrin, Beth Hodshon, John A Spertus
BACKGROUND: Although noninvasive telemonitoring in patients with heart failure does not reduce mortality or hospitalizations, less is known about its effect on health status. This study reports the results of a randomized clinical trial of telemonitoring on health status in patients with heart failure. METHODS AND RESULTS: Among 1521 patients with recent heart failure hospitalization randomized in the Tele-HF trial (Telemonitoring to Improve Heart Failure Outcomes), 756 received telephonic monitoring and 765 usual care...
December 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29231837/the-primary-health-care-system-in-china
#16
REVIEW
Xi Li, Jiapeng Lu, Shuang Hu, K K Cheng, Jan De Maeseneer, Qingyue Meng, Elias Mossialos, Dong Roman Xu, Winnie Yip, Hongzhao Zhang, Harlan M Krumholz, Lixin Jiang, Shengshou Hu
China has made remarkable progress in strengthening its primary health-care system. Nevertheless, the system still faces challenges in structural characteristics, incentives and policies, and quality of care, all of which diminish its preparedness to care for a fifth of the world's population, which is ageing and which has a growing prevalence of chronic non-communicable disease. These challenges include inadequate education and qualifications of its workforce, ageing and turnover of village doctors, fragmented health information technology systems, a paucity of digital data on everyday clinical practice, financial subsidies and incentives that do not encourage cost savings and good performance, insurance policies that hamper the efficiency of care delivery, an insufficient quality measurement and improvement system, and poor performance in the control of risk factors (such as hypertension and diabetes)...
December 9, 2017: Lancet
https://www.readbyqxmd.com/read/29221982/hypothermic-cardiopulmonary-bypass-weaning-and-prolonged-postoperative-rewarming-in-a-patient-with-intraoperative-oxygenator-thrombosis
#17
Ian Grant, Max Breidenstein, Ana Parsee, Charles Krumholz, Jacob Martin
No abstract text is available yet for this article.
September 14, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29206052/risk-trajectories-of-readmission-and-death-in-the-first-year-following-hospitalization-for-copd
#18
Peter K Lindenauer, Kumar Dharmarajan, Li Qin, Zhenqui Lin, Andrea S Gershon, Harlan M Krumholz
Rationale Characterizing the dynamic nature of post-hospital risk in COPD is needed to provide counseling and plan clinical services. Objectives To analyze risk of readmission and death among Medicare beneficiaries >=65 years following discharge for COPD, and to determine the association between ventilator support and risk trajectory. Methods We computed daily absolute risks of hospital readmission and death for one year after discharge for COPD, stratified by ventilator support. We determined the time required for risks to decline 50% from maximum daily values after discharge; and for daily risks to plateau...
December 5, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29183077/adherence-to-methodological-standards-in-research-using-the-national-inpatient-sample
#19
Rohan Khera, Suveen Angraal, Tyler Couch, John W Welsh, Brahmajee K Nallamothu, Saket Girotra, Paul S Chan, Harlan M Krumholz
Importance: Publicly available data sets hold much potential, but their unique design may require specific analytic approaches. Objective: To determine adherence to appropriate research practices for a frequently used large public database, the National Inpatient Sample (NIS) of the Agency for Healthcare Research and Quality (AHRQ). Design, Setting, and Participants: In this observational study of the 1082 studies published using the NIS from January 2015 through December 2016, a representative sample of 120 studies was systematically evaluated for adherence to practices required by AHRQ for the design and conduct of research using the NIS...
November 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29169478/2017-roadmap-for-innovation-acc%C3%A2-health-policy-statement-on-healthcare-transformation-in-the-era%C3%A2-of-digital-health-big-data-and%C3%A2-precision-health-a-report-of-the-american-college-of-cardiology-task-force-on-health-policy-statements-and-systems-of-care
#20
Sanjeev P Bhavnani, Kapil Parakh, Ashish Atreja, Regina Druz, Garth N Graham, Salim S Hayek, Harlan M Krumholz, Thomas M Maddox, Maulik D Majmudar, John S Rumsfeld, Bimal R Shah
No abstract text is available yet for this article.
November 28, 2017: Journal of the American College of Cardiology
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