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https://www.readbyqxmd.com/read/28196521/comparison-of-two-independent-systematic-reviews-of-trials-of-recombinant-human-bone-morphogenetic-protein-2-rhbmp-2-the-yale-open-data-access-medtronic-project
#1
Jeffrey Low, Joseph S Ross, Jessica D Ritchie, Cary P Gross, Richard Lehman, Haiqun Lin, Rongwei Fu, Lesley A Stewart, Harlan M Krumholz
BACKGROUND: It is uncertain whether the replication of systematic reviews, particularly those with the same objectives and resources, would employ similar methods and/or arrive at identical findings. We compared the results and conclusions of two concurrent systematic reviews undertaken by two independent research teams provided with the same objectives, resources, and individual participant-level data. METHODS: Two centers in the USA and UK were each provided with participant-level data on 17 multi-site clinical trials of recombinant human bone morphogenetic protein-2 (rhBMP-2)...
February 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28153989/sex-differences-in-1-year-all-cause-rehospitalization-in-patients-after-acute-myocardial-infarction-a-prospective-observational-study
#2
Rachel P Dreyer, Kumar Dharmarajan, Kevin F Kennedy, Philip G Jones, Viola Vaccarino, Karthik Murugiah, Sudhakar V Nuti, Kim G Smolderen, Donna M Buchanan, John A Spertus, Harlan M Krumholz
BACKGROUND: Compared with men, women are at higher risk of rehospitalization in the first month after discharge for acute myocardial infarction (AMI). However, it is unknown whether this risk extends to the full year and varies by age. Explanatory factors potentially mediating the relationship between sex and rehospitalization remain unexplored and are needed to reduce readmissions. The aim of this study was to assess sex differences and factors associated with 1-year rehospitalization rates after AMI...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28148599/national-trends-in-atrial-fibrillation-hospitalization-readmission-and-mortality-for-medicare-beneficiaries-1999-2013
#3
James V Freeman, Yun Wang, Joseph G Akar, Nihar Desai, Harlan M Krumholz
BACKGROUND: -Data is lacking on national trends for atrial fibrillation (AF) hospitalization, particularly with regards to long-term outcomes including readmission and mortality. METHODS: -We studied all Medicare fee-for-service beneficiaries between 1999 and 2013, and evaluated rates of hospitalization for AF, in-hospital mortality, length-of-stay, and hospital payments. We then evaluated rates of longer-term outcomes including 30-day readmission, 30-day mortality, and 1-year mortality...
February 1, 2017: Circulation
https://www.readbyqxmd.com/read/28135350/copy-fees-and-limitation-of-patients-access-to-their-own-medical-records
#4
Austin W Jaspers, Jennifer L Cox, Harlan M Krumholz
No abstract text is available yet for this article.
January 30, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28132746/acc-aha-special-report-clinical%C3%A2-practice-guideline-implementation-strategies-a%C3%A2-summary-of-systematic-reviews-by-the-nhlbi-implementation-science-work-group-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice
#5
Wiley V Chan, Thomas A Pearson, Glen C Bennett, William C Cushman, Thomas A Gaziano, Paul N Gorman, Joel Handler, Harlan M Krumholz, Robert F Kushner, Thomas D MacKenzie, Ralph L Sacco, Sidney C Smith, Victor J Stevens, Barbara L Wells
BACKGROUND: In 2008, the National Heart, Lung, and Blood Institute convened an Implementation Science Work Group to assess evidence-based strategies for effectively implementing clinical practice guidelines. This was part of a larger effort to update existing clinical practice guidelines on cholesterol, blood pressure, and overweight/obesity. OBJECTIVES: Review evidence from the published implementation science literature and identify effective or promising strategies to enhance the adoption and implementation of clinical practice guidelines...
January 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28126839/acc-aha-special-report-clinical-practice-guideline-implementation-strategies-a-summary-of-systematic-reviews-by-the-nhlbi-implementation-science-work-group-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-practice
#6
Wiley V Chan, Thomas A Pearson, Glen C Bennett, William C Cushman, Thomas A Gaziano, Paul N Gorman, Joel Handler, Harlan M Krumholz, Robert F Kushner, Thomas D MacKenzie, Ralph L Sacco, Sidney C Smith, Victor J Stevens, Barbara L Wells, Graciela Castillo, Susan K R Heil, Jennifer Stephens, Julie C Jacobson Vann
BACKGROUND: In 2008, the National Heart, Lung, and Blood Institute convened an Implementation Science Work Group to assess evidence-based strategies for effectively implementing clinical practice guidelines. This was part of a larger effort to update existing clinical practice guidelines on cholesterol, blood pressure, and overweight/obesity. OBJECTIVES: Review evidence from the published implementation science literature and identify effective or promising strategies to enhance the adoption and implementation of clinical practice guidelines...
January 26, 2017: Circulation
https://www.readbyqxmd.com/read/28125758/is-hemoglobin-a1c-the-right-outcome-for-studies-of-diabetes
#7
Kasia J Lipska, Harlan M Krumholz
No abstract text is available yet for this article.
January 26, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28027367/association-between-hospital-penalty-status-under-the-hospital-readmission-reduction-program-and-readmission-rates-for-target-and-nontarget-conditions
#8
COMPARATIVE STUDY
Nihar R Desai, Joseph S Ross, Ji Young Kwon, Jeph Herrin, Kumar Dharmarajan, Susannah M Bernheim, Harlan M Krumholz, Leora I Horwitz
Importance: Readmission rates declined after announcement of the Hospital Readmission Reduction Program (HRRP), which penalizes hospitals for excess readmissions for acute myocardial infarction (AMI), heart failure (HF), and pneumonia. Objective: To compare trends in readmission rates for target and nontarget conditions, stratified by hospital penalty status. Design, Setting, and Participants: Retrospective cohort study of Medicare fee-for-service beneficiaries older than 64 years discharged between January 1, 2008, and June 30, 2015, from 2214 penalty hospitals and 1283 nonpenalty hospitals...
27, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27984507/perceived-stress-after-acute-myocardial-infarction-a-comparison-between-young-and-middle-aged-women-versus-men
#9
Xiao Xu, Haikun Bao, Kelly M Strait, Donald E Edmondson, Karina W Davidson, John F Beltrame, Héctor Bueno, Haiqun Lin, Rachel P Dreyer, John E Brush, John A Spertus, Judith H Lichtman, Gail DʼOnofrio, Harlan M Krumholz
OBJECTIVE: The aim of the study was to examine how psychological stress changes over time in young and middle-aged patients after experiencing an acute myocardial infarction (AMI) and whether these changes differ between men and women. METHODS: We analyzed data obtained from 2358 women and 1151 men aged 18 to 55 years hospitalized for AMI. Psychological stress was measured using the 14-item Perceived Stress Scale (PSS-14) at initial hospitalization and at 1 month and 12 months after AMI...
January 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27979045/sex-differences-in-lipid-profiles-and-treatment-utilization-among-young-adults-with-acute-myocardial-infarction-results-from-the-virgo-study
#10
Yuan Lu, Shengfan Zhou, Rachel P Dreyer, Michael Caulfield, Erica S Spatz, Mary Geda, Nancy P Lorenze, Peter Herbert, Gail D'Onofrio, Elizabeth A Jackson, Judith H Lichtman, Héctor Bueno, John A Spertus, Harlan M Krumholz
BACKGROUND: Young women with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. An adverse lipid profile is an important risk factor for cardiovascular outcomes after AMI, but little is known about whether young women with AMI have a higher-risk lipid pattern than men. We characterized sex differences in lipid profiles and treatment utilization among young adults with AMI. METHODS: A total of 2,219 adults with AMI (1,494 women) aged 18-55 years were enrolled from 103 hospitals in the United States (2008-2012)...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27974869/community-level-association-between-home-health-and-nursing-home-performance-on-quality-and-hospital-30-day-readmissions-for-medicare-patients
#11
Yun Wang, Michelle M Pandolfi, Jonathan Fine, Mark L Metersky, Changqin Wang, Shih-Yieh Ho, Deron Galusha, Sudhakar V Nuti, Karthik Murugiah, Ann Spenard, Timothy Elwell, Harlan M Krumholz
We evaluated whether community-level home health agencies and nursing home performance is associated with community-level hospital 30-day all-cause risk-standardized readmission rates for Medicare patients used data from the Centers for Medicare & Medicaid Service from 2010 to 2012. Our final sample included 2,855 communities that covered 4,140 hospitals with 6,751,713 patients, 13,060 nursing homes with 1,250,648 residents, and 7,613 home health agencies providing services to 35,660 zipcodes. Based on a mixed effect model, we found that increasing nursing home performance by one star for all of its 4 measures and home health performance by 10 points for all of its 6 measures is associated with decreases of 0...
November 2016: Home Health Care Management & Practice
https://www.readbyqxmd.com/read/27933194/contribution-of-the-long-term-care-insurance-certificate-for-predicting-1-year-all-cause-readmission-compared-with-validated-risk-scores-in-elderly-patients-with-heart-failure
#12
Kayo Takahashi, Makoto Saito, Shinji Inaba, Toru Morofuji, Hiroe Aisu, Takumi Sumimoto, Akiyoshi Ogimoto, Shuntaro Ikeda, Jitsuo Higaki
OBJECTIVES: Readmission is a common and serious problem associated with heart failure (HF). Unfortunately, conventional risk models have limited predictive value for predicting readmission. The recipients of long-term care insurance (LTCI) are frail and have mental and physical impairments. We hypothesised that adjustment of the conventional risk score with an LTCI certificate enables a more accurate appreciation of readmission for HF. METHODS: We investigated 452 patients with HF who were followed up for 1 year to determine all-cause readmission...
2016: Open Heart
https://www.readbyqxmd.com/read/27885060/gender-differences-in-physical-activity-following-acute-myocardial-infarction-in-adults-a-prospective-observational-study
#13
Karl E Minges, Kelly M Strait, Neville Owen, David W Dunstan, Sarah M Camhi, Judith Lichtman, Mary Geda, Rachel P Dreyer, Héctor Bueno, John F Beltrame, Jeptha P Curtis, Harlan M Krumholz
Aims Despite the benefits of regular physical activity participation following acute myocardial infarction, little is known about gender differences in physical activity among patients after acute myocardial infarction. We described, by gender, physical activity trajectories pre- and post-acute myocardial infarction, and determined whether gender was independently associated with physical activity. Methods and results The Variation in Recovery: Role of Gender on Outcomes of Young AMI patients (VIRGO) study, conducted at 103 US, 24 Spanish, and three Australian hospitals, was designed, in part, to evaluate gender differences in lifestyle behaviors following acute myocardial infarction...
January 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27884254/troponin-testing-for-clinicians
#14
REVIEW
John E Brush, Sanjay Kaul, Harlan M Krumholz
The analytical performance of troponin assays has improved markedly in the last 2 decades. The variety of assays, their evolution over time, and their critical importance in influencing care, mandates the need for skills in their use. There are 3 critical elements necessary for optimal use of troponin testing in clinical care, as follows: 1) the analytical performance of the assay; 2) the clinical sensitivity and specificity of the test result; and 3) the clinical reasoning for ordering and the proper clinical context for interpreting the test result...
November 29, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27874977/relationship-between-age-and-trajectories-of-rehospitalization-risk-in-older-adults
#15
Kumar Dharmarajan, Angela Hsieh, Rachel P Dreyer, Jack Welsh, Li Qin, Harlan M Krumholz
OBJECTIVES: To characterize the magnitude and duration of risk of rehospitalization according to age after hospitalization for heart failure (HF), acute myocardial infarction (AMI), or pneumonia. DESIGN: Retrospective cohort study. SETTING: U.S. hospitals (n = 4,767). PARTICIPANTS: All Medicare fee-for-service beneficiaries aged 65 and older surviving hospitalization for HF, AMI, or pneumonia between October 2012 and December 2013...
February 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27864915/identification-of-emergency-department-visits-in-medicare-administrative-claims-approaches-and-implications
#16
Arjun K Venkatesh, Hao Mei, Keith Kocher, Mike Granovsky, Ziad Obermeyer, Erica Spatz, Craig Rothenberg, Harlan Krumholz, Zhenqui Lin
OBJECTIVES: Administrative claims datasets are often used for emergency care research and policy investigations of healthcare resource utilization, acute care practices, and evaluation of quality improvement interventions. Despite the high profile of emergency department (ED) visits in analyses using administrative claims, little work has evaluated the degree to which existing definitions based on claims data accurately captures conventionally defined hospital-based ED services. We sought to construct an operational definition for ED visitation using a comprehensive Medicare dataset and to compare this definition to existing operational definitions used by researchers and policymakers...
November 19, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27834249/population-well-being-measures-help-explain-geographic-disparities-in-life-expectancy-at-the-county-level
#17
Anita Arora, Erica Spatz, Jeph Herrin, Carley Riley, Brita Roy, Kenneth Kell, Carter Coberley, Elizabeth Rula, Harlan M Krumholz
Geographic disparities in life expectancy are substantial and not fully explained by differences in race and socioeconomic status. To develop policies that address these inequalities, it is essential to identify other factors that account for this variation. In this study we investigated whether population well-being-a comprehensive measure of physical, mental, and social health-helps explain geographic variation in life expectancy. At the county level, we found that for every 1-standard-deviation (4.2-point) increase in the well-being score, life expectancy was 1...
November 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27806161/data-desert-for-inferior-vena-caval-filters-limited-evidence-supervision-and-research
#18
Behnood Bikdeli, Joseph S Ross, Harlan M Krumholz
No abstract text is available yet for this article.
January 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27803089/access-to-evidence-based-statins-in-low-cost-generic-drug-programs
#19
Cynthia A Jackevicius, Katie Choi, Harlan M Krumholz
No abstract text is available yet for this article.
November 1, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27798032/china-peace-risk-estimation-tool-for-in-hospital-death-from-acute-myocardial-infarction-an-early-risk-classification-tree-for-decisions-about-fibrinolytic-therapy
#20
Xi Li, Jing Li, Frederick A Masoudi, John A Spertus, Zhenqiu Lin, Harlan M Krumholz, Lixin Jiang
OBJECTIVES: As the predominant approach to acute reperfusion for ST segment elevation myocardial infarction (STEMI) in many countries, fibrinolytic therapy provides a relative risk reduction for death of ∼16% across the range of baseline risk. For patients with low baseline mortality risk, fibrinolytic therapy may therefore provide little benefit, which may be offset by the risk of major bleeding. We aimed to construct a tool to determine if it is possible to identify a low-risk group among fibrinolytic therapy-eligible patients...
October 24, 2016: BMJ Open
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