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https://www.readbyqxmd.com/read/28811944/successful-resuscitation-of-a-patient-with-life-threatening-metabolic-acidosis-by-hemodialysis-a-case-of-ethylene-glycol-intoxication
#1
Ikuyo Narita, Michiko Shimada, Norio Nakamura, Reiichi Murakami, Takeshi Fujita, Wakako Fukuda, Hirofumi Tomita
BACKGROUND: Ethylene glycol intoxication causes severe metabolic acidosis and acute kidney injury. Fomepizole has become available as its antidote. Nevertheless, a prompt diagnosis is not easy because patients are often unconscious. Here we present a case of ethylene glycol intoxication who successfully recovered with prompt hemodialysis. CASE PRESENTATION: A 52-year-old Japanese male was admitted to a local hospital due to suspected food poisoning. The patient presented with nausea and vomiting, but his condition rapidly deteriorated, with worsening conscious level, respiratory distress requiring mechanical ventilation, hypotension, and severe acute kidney injury...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/28811602/identification-of-ciguatoxins-in-a-shark-involved-in-a-fatal-food-poisoning-in-the-indian-ocean
#2
Jorge Diogène, Laia Reverté, Maria Rambla-Alegre, Vanessa Del Río, Pablo de la Iglesia, Mònica Campàs, Oscar Palacios, Cintia Flores, Josep Caixach, Christian Ralijaona, Iony Razanajatovo, Agathe Pirog, Hélène Magalon, Nathalie Arnich, Jean Turquet
Severe food poisoning events after the consumption of sharks have been reported since the 1940s; however, there has been no clear understanding of their cause. Herein, we report for the first time the presence of ciguatoxins (CTXs) in sharks. The identification by mass spectrometry of CTXs, including two new analogues, in a bull shark (Carcharhinus leucas) that was consumed by humans, causing the poisoning and death of 11 people in Madagascar in 2013 is described. Typical neurotoxic ciguatera symptoms were recorded in patients, and toxicological assays on extracts of the shark demonstrated CTX-like activity...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780794/-a-investigation-of-phosphine-poisoning-was-misdiagnosed-food-poisoning
#3
N Li, Q M Xiao, H N Qi
No abstract text is available yet for this article.
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28777321/prevalence-and-genetic-characteristics-of-staphylococcus-aureus-and-staphylococcus-argenteus-isolates-harboring-panton-valentine-leukocidin-enterotoxins-and-tsst-1-genes-from-food-handlers-in-myanmar
#4
Meiji Soe Aung, Thida San, Mya Mya Aye, San Mya, Win Win Maw, Khin Nyein Zan, Wut Hmone Win Htut, Mitsuyo Kawaguchiya, Noriko Urushibara, Nobumichi Kobayashi
Asymptomatic carriers of toxigenic Staphylococcus aureus are potential source of diseases, including food poisoning. Toxigenic potential and genetic traits of colonizing S. aureus were investigated for 563 healthy food handlers in Myanmar. Carriage of S. aureus was found in 110 individuals (19.5%), and a total of 144 S. aureus isolates were recovered from nasal cavities (110 isolates) and hands (34 isolates). Panton-Valentine leucocidin genes (pvl) were detected in 18 isolates (12.5%), among which 11 isolates were classified into coa-VIa, agr type III, and ST1930 (CC96) that had been also detected in pvl-positive clinical isolates in Myanmar...
August 4, 2017: Toxins
https://www.readbyqxmd.com/read/28776895/characterization-of-sarcocystis-fayeri-s-actin-depolymerizing-factor-as-a-toxin-that-causes-diarrhea
#5
Daisuke Irikura, Morihiro Saito, Yoshiko Sugita-Konishi, Takahiro Ohnishi, Kei-Ichi Sugiyama, Maiko Watanabe, Akiko Yamazaki, Shinji Izumiyama, Hirotaka Sato, Yusuke Kimura, Rie Doi, Yoichi Kamata
Raw horsemeat has the potential to induce food poisoning which often presents with diarrheal symptoms. A sample of horsemeat was found to be infected with Sarcocystis fayeri, and a 15-kDa protein isolated from the cysts of S. fayeri was found to clearly show its diarrhea-inducing activity. A nested polymerase chain reaction was used to clone the cDNA of the 15-kDa protein. The deduced amino acid sequence showed homology to actin-depolymerizing factor (ADF). A recombinant 15-kDa protein depolymerized prepolymerized actins in a test tube...
August 4, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28768476/pan-genome-and-phylogeny-of-bacillus-cereus-sensu-lato
#6
Adam L Bazinet
BACKGROUND: Bacillus cereus sensu lato (s. l.) is an ecologically diverse bacterial group of medical and agricultural significance. In this study, I use publicly available genomes and novel bioinformatic workflows to characterize the B. cereus s. l. pan-genome and perform the largest phylogenetic and population genetic analyses of this group to date in terms of the number of genes and taxa included. With these fundamental data in hand, I identify genes associated with particular phenotypic traits (i...
August 2, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28758289/changes-in-misuse-and-abuse-of-prescription-opioids-following-implementation-of-extended-release-and-long-acting-opioid-analgesic-risk-evaluation-and-mitigation-strategy
#7
Becki Bucher Bartelson, M Claire Le Lait, Jody L Green, M Soledad Cepeda, Paul M Coplan, Jean-Yves Maziere, Gregory P Wedin, Richard C Dart
PURPOSE: An unintended consequence of extended-release (ER) and long-acting (LA) prescription opioids is that these formulations can be more attractive to abusers than immediate-release (IR) formulations. The US Food and Drug Administration recognized these risks and approved the ER/LA Opioid Analgesic Risk Evaluation and Mitigation Strategy (ER/LA REMS), which has a goal of reducing opioid misuse and abuse and their associated consequences. The primary objective of this analysis is to determine whether ER/LA REMS implementation was associated with decreased reports of misuse and abuse...
July 31, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28755953/kidney-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-3-of-5-series
#8
REVIEW
Amy Christine Brown
BACKGROUND: No tabular summary of potentially life-threatening, kidney-toxic dietary supplements (DS; includes herbs) based on PubMed case reports is currently available online and continually updated to forewarn United States consumers, clinicians, and companies manufacturing DS. The purpose of this review was to create an online research summary table of kidney toxicity case reports related to DS. METHODS: Documented PubMed case reports (1966 to May 2016, and cross-referencing) of DS appearing to contribute to kidney toxicity were listed in "DS Toxic Tables...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28753923/an-overview-of-seafood-supply-food-safety-and-regulation-in-new-south-wales-australia
#9
REVIEW
Malik A Hussain, Themy Saputra, Elizabeth A Szabo, Bruce Nelan
Seafood consumption is increasing in Australia, especially in New South Wales (NSW). Average per capita seafood consumption in NSW is higher than the national average. Seafood supply in NSW comes from domestic (wild catch and aquaculture) and overseas (seafood imports) sources. The contribution of wild catch and aquaculture in domestic seafood production (2012-2013) was 73.42% and 26.52%, respectively. Seafood-associated foodborne illness outbreaks are not common and on an average four outbreaks occur each year in NSW...
July 19, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28753035/quantitative-prevalence-phenotypic-and-genotypic-characteristics-of-bacillus-cereus-isolated-from-retail-infant-foods-in-china
#10
Yunyi Zhang, Jiancai Chen, Chunyan Feng, Li Zhan, Junyan Zhang, Yi Li, Yong Yang, Honghu Chen, Zheng Zhang, Yanjun Zhang, Lingling Mei, Haifeng Li
Bacillus cereus is an important foodborne pathogen, which can cause severe food poisoning. The aim of this study was (i) to evaluate the quantitative prevalence of B. cereus in retail prepackaged infant formula and ready-to-eat rice flour in China and (ii) to gain the basic information on pheno- and genotypic characteristics of B. cereus isolates. We found that 40 out of the 587 samples were positive for B. cereus. B. cereus in 3.5% of infant formula samples and 1.0% of rice flour samples outnumbered 100 Colony-Forming Units (CFU)/g...
July 28, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28748745/histamine-poisoning-from-insect-consumption-an-outbreak-investigation-from-thailand
#11
Summon Chomchai, Chulathida Chomchai
BACKGROUND: Insect consumption is a common practice in the Asian culture and all over the world. We are reporting an outbreak investigation of histamine poisoning from ingestion of fried insects. METHODS: On 24 July 2014, a group of students at a seminar presented to Angthong Provincial Hospital, Thailand, with pruritic rash after ingesting snacks consisting of fried insects from a vendor. We initiated an outbreak investigation with retrospective cohort design and collected samples of remaining foods for analyses...
July 27, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28722512/in-silico-and-in-vitro-evaluation-of-two-novel-oximes-k378-and-k727-in-comparison-to-k27-and-pralidoxime-against-paraoxon-ethyl-intoxication
#12
Maria Chaudhry, Muhammad Qaiser Fatmi, Kamil Musilek, Alamdar Hussain, Kamil Kuca, Georg Petroianu, Huba Kalasz, Syed Muhammad Nurulain
Organophosphate (OP) poisoning is a major global health issue; while compounds from this group have been used intensively over the last century, an effective antidote is still lacking. Oxime-type AChE reactivators are used to reactivate the OP inhibited AChE. Pralidoxime is the only US Food and Drug Administration, (FDA) approved oxime for therapeutic use but its efficacy has been disappointing. Two novel oximes (K378 and K727) were investigated in silico and in vitro and compared with an experimental oxime (kamiloxime; K-27) and pralidoxime...
July 19, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28710688/death-by-food
#13
Roger W Byard
Although death from food is not an uncommon finding in forensic facilities worldwide, the range of underlying lethal mechanisms and associated conditions that should be sought at the time of autopsy is quite disparate. Deaths may occur from i) infectious agents including bacteria, viruses, protozoa, cestodes, nematodes and prions; ii) natural toxins including amanita toxins, tetrodotoxin, ciguatera and scombroid; iii) anaphylaxis; iv) poisoning; v) mechanical issues around airway and gut obstruction and/or perforation; and vi) miscellaneous causes...
July 15, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28710607/evaluation-of-a-food-and-drug-administration-mandate-to-limit-acetaminophen-in-prescription-combination-products
#14
David Goldberger, David Vearrier
INTRODUCTION: In 2014, the US Food and Drug Administration limited the production of prescription acetaminophen-opioid combination products to 325 mg per dose unit. The goal of this mandate was to decrease the likelihood of unintentional acetaminophen hepatotoxicity. This study was designed to determine if this federal regulation has succeeded in reducing unintentional acetaminophen-induced hepatotoxicity from opioid combination products. METHODS: Using data from the National Poison Data System (NPDS), we analyzed all calls to US Poison Control Centers in the years 2013 and 2015 for acetaminophen-opioid combination product exposures...
July 14, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28708027/do-valenced-odors-and-trait-body-odor-disgust-affect-evaluation-of-emotion-in-dynamic-faces
#15
Elmeri Syrjänen, Marco Tullio Liuzza, Håkan Fischer, Jonas K Olofsson
Disgust is a core emotion evolved to detect and avoid the ingestion of poisonous food as well as the contact with pathogens and other harmful agents. Previous research has shown that multisensory presentation of olfactory and visual information may strengthen the processing of disgust-relevant information. However, it is not known whether these findings extend to dynamic facial stimuli that changes from neutral to emotionally expressive, or if individual differences in trait body odor disgust may influence the processing of disgust-related information...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28697162/pediatric-orbeez-ingestions-reported-to-texas-poison-centers
#16
Mathias B Forrester
OBJECTIVES: There is concern that ingestion of superabsorbent polymer toys, which can absorb large amounts of fluid and increase greatly in volume, may pose a risk if swallowed by children.The intent of this study was to characterize pediatric Orbeez ingestions reported to a statewide poison center system. METHODS: Cases were Orbeez ingestions among patients 19 years or younger reported to Texas poison centers during January 2011 to June 2016. The distribution by various demographic and clinical factors was determined...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28690303/pcr-based-method-for-the-detection-of-toxic-mushrooms-causing-food-poisoning-incidents
#17
Chie Nomura, Atsushi Masayama, Mizuka Yamaguchi, Daisuke Sakuma, Keiji Kajimura
In this study, species-specific identification of five toxic mushrooms, Chlorophyllum molybdites, Gymnopilus junonius, Hypholoma fasciculare, Pleurocybella porrigens, and Tricholoma ustale, which have been involved in food-poisoning incidents in Japan, was investigated. Specific primer pairs targeting internal transcribed spacer (ITS) regions were designed for PCR detection. The specific amplicons were obtained from fresh, cooked, and simulated gastric fluid (SGF)-treated samples. No amplicons were detected from other mushrooms with similar morphology...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28690301/rapid-identification-method-of-omphalotus-japonicus-by-polymerase-chain-reaction-restriction-fragment-length-polymorphism-pcr-rflp
#18
Yohei Sugano, Kozue Sakata, Kosuke Nakamura, Akio Noguchi, Nozomi Fukuda, Tomohiro Suzuki, Kazunari Kondo
Omphalotus japonicus is a poisonous mushroom that grows in Japan. It can be mistaken for edible mushrooms (Shiitake, Hiratake and Mukitake), and if ingested, it causes food poisoning within 30 min to 1 hr. We established a rapid detection method using PCR-RFLP to identify O. japonicus by restriction digestion of the amplified ITS region. By using Sau96I, Bpu10I, SfcI or DrdI/HincII as a restriction enzyme, it was possible to rapidly identify and discriminate O. japonicus based on the fragment length. This study also provided a short PCR-RFLP system comprising amplification and digestion of a short 200-bp DNA fragment within the ITS region...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28684374/investigating-crispr-cas-systems-in-clostridium-botulinum-via-bioinformatics-tools
#19
Manica Negahdaripour, Navid Nezafat, Nasim Hajighahramani, Seyyed Soheil Rahmatabadi, Younes Ghasemi
The Clustered regularly interspaced short palindromic repeats (CRISPR) systems are a type of innate immunity found in some prokaryotes, which protect them against alien genetic elements by targeting foreign nucleic acids. Some other functions are also attributed to these systems. Clostridium botulinum bacteria produce botulinum neurotoxins (BoNT), one of the deadliest known toxins for humans and some animals. Food poisoning due to these bacteria is still a challenge in food industries. On the other hand, BoNT has been widely investigated for therapeutic applications including different muscle disorders...
July 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28682565/-digoxin-poisoning-new-prospects-for-therapy
#20
Alfonsina Marino, Lorenzo Giordano, Francesco Ardu
The filter has been approved by the Food and Drug Administration for the removal of beta-2 microglobulin in patient undergoing hemodialysis. We used the filter (the patient agrees) off label, in the course of digitalis intoxication and we have shown that the filter is capable of removing the drug effectively.
April 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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