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https://www.readbyqxmd.com/read/27909580/burden-of-neisseria-meningitidis-infections-in-china-a-systematic-review-and-meta-analysis
#1
Yaowen Zhang, Dong Wei, Xinzhen Guo, Mai Han, Lichao Yuan, Moe H Kyaw
BACKGROUND: Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia in children and young adults worldwide. The disease burden associated with N. meningitidis infections has not been systematically assessed in China. Therefore, we undertook this study to determine the burden of meningococcal disease in China. METHOD: We performed a systematic review and meta-analysis of articles on N. meningitidis incidence, carriage, seroprevalence and mortality rates in China by searching the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed for publications from January 2005 to Aug 2015...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27907129/meningococcal-carriage-in-military-recruits-and-university-students-during-the-pre-menb-vaccination-era-in-greece-2014-2015
#2
Kyriaki Tryfinopoulou, Konstantinos Kesanopoulos, Athanasia Xirogianni, Nektarios Marmaras, Anastasia Papandreou, Vassiliki Papaevangelou, Maria Tsolia, Aftab Jasir, Georgina Tzanakaki
PURPOSE: The aim of the study was to estimate the meningococcal carriage rate and to identify the genotypic characteristics of the strains isolated from healthy military recruits and university students in order to provide data that might increase our understanding on the epidemiology of meningococcus and obtain information which helps to evaluate the potential effects on control programs such as vaccination. METHODS: A total of 1420 oropharyngeal single swab samples were collected from military recruits and university students on voluntary basis, aged 18-26 years...
2016: PloS One
https://www.readbyqxmd.com/read/27904879/the-establishment-and-diversification-of-epidemic-associated-serogroup-w-meningococcus-in-the-african-meningitis-belt-1994-to-2012
#3
Adam C Retchless, Fang Hu, Abdoul-Salam Ouédraogo, Seydou Diarra, Kristen Knipe, Mili Sheth, Lori A Rowe, Lassana Sangaré, Absetou Ky Ba, Soumeya Ouangraoua, Dhwani Batra, Ryan T Novak, Rasmata Ouédraogo Traoré, Xin Wang
Epidemics of invasive meningococcal disease (IMD) caused by meningococcal serogroup A have been eliminated from the sub-Saharan African so-called "meningitis belt" by the meningococcal A conjugate vaccine (MACV), and yet, other serogroups continue to cause epidemics. Neisseria meningitidis serogroup W remains a major cause of disease in the region, with most isolates belonging to clonal complex 11 (CC11). Here, the genetic variation within and between epidemic-associated strains was assessed by sequencing the genomes of 92 N...
November 2016: MSphere
https://www.readbyqxmd.com/read/27902653/meningococcal-disease-in-children-in-argentina-a-three-year-active-sentinel-hospital-surveillance-study
#4
Ángela Gentile, Julia Bakir, María Rosa Agosti, Gabriela Ensinck, Hector Abate, Andrea Gajo Gane, Alejandro Santillán Iturres, Adriana Efron, Mabel Regueira, Ricardo Rüttimann
BACKGROUND: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. METHODS: 3-year prospective active surveillance in patients ≤15 years of age conducted at 6 pediatric hospital sentinel units (March 2012-February 2015)...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27901251/meningococcal-meningitis-clinical-and-laboratorial-characteristics-fatality-rate-and-variables-associated-with-in-hospital-mortality
#5
Vanessa L Strelow, Érique José F Peixoto de Miranda, Karin R Kolbe, Juliana V Souza Framil, Augusto Penalva de Oliveira, José E Vidal
Meningococcal meningitis is a public health problem. The aim of this study was to describe the clinical characteristics of patients with meningococcal meningitis, and to identify associated factors with mortality. This was a retrospective study, between 2006 and 2011, at a referral center in São Paulo, Brazil. Logistic regression analysis was used to identify factors associated with mortality. We included 316 patients. The median age was 16 years (IQR: 7-27) and 60% were male. The clinical triad: fever, headache and neck stiffness was observed in 89% of the patients...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27893784/circadian-variation-of-plasminogen-activator-inhibitor-1-levels-in-children-with-meningococcal-sepsis
#6
Navin P Boeddha, Gertjan J Driessen, Marjon H Cnossen, Jan A Hazelzet, Marieke Emonts
OBJECTIVE: To study whether the circadian variation of plasminogen-activator-inhibitor-1 (PAI-1) levels, with high morning levels, is associated with poor outcome of children with meningococcal sepsis presenting in the morning hours. DESIGN: Retrospective analysis of prospectively collected clinical and laboratory data. SETTING: Single center study at Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. SUBJECTS: 184 patients aged 3 weeks to 18 years with meningococcal sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/27889997/acute-cystitis-caused-by-commensal-neisseria-oralis-a-case-report-and-review-of-the-literature
#7
Yassar Alamri, Aaron Keene, Alan Pithie
Neisseria are usually harmless inhabitants of otherwise asymptomatic persons' upper respiratory mucosal surfaces. It is, therefore, expected that a disturbance in the physiology leads to non-gonococcal, non-meningococcal Neisseria becoming pathogenic. We report the case of a diabetic man who initially presented with non-specific symptoms and was later found to have cystitis caused by N. oralis. We also review the pertinent literature and discuss available evidence on pathophysiological mechanisms of infection with such commensal bacteria...
November 23, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27884478/vaccine-provision-delivering-sustained-widespread-use
#8
Scott Preiss, Nathalie Garçon, Anthony L Cunningham, Richard Strugnell, Leonard R Friedland
The administration of a vaccine to a recipient is the final step in a development and production process that may have begun several decades earlier. Here we describe the scale and complexity of the processes that brings a candidate vaccine through clinical development to the recipient. These challenges include ensuring vaccine quality (between 100 and 500 different Quality Control tests are performed during production to continually assess safety, potency and purity); making decisions about optimal vaccine presentation (pre-filled syringes versus multi-dose vials) that affect capacity and supply; and the importance of maintaining the vaccine cold chain (most vaccines have stringent storage temperature requirements necessary to maintain activity and potency)...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27881489/kinetics-of-meningococcal-serogroup-c-specific-functional-antibody-levels-up-to-15-years-after-a-single-immunization-with-a-meningococcal-serogroup-c-conjugate-vaccine-during-adolescence
#9
Susanne P Stoof, Mariëtte B van Ravenhorst, Debbie M van Rooijen, Richarda M de Voer, Fiona R M van der Klis, Greet J Boland, Elisabeth A M Sanders, Guy A M Berbers, Peter F Teunis
BACKGROUND: Adolescent vaccination is now considered the key factor to offer direct protection against meningococcal disease but also to reduce carriage and transmission and in this way establish herd protection. This study estimated age-dependent patterns in functional meningococcal serogroup C (MenC) antibody kinetics after primary MenC conjugate (MenCC) vaccination in adolescents. METHODS: Serum samples (n=1676) were drawn between 2006-2011 from individuals aged 9-18 years at time of primary MenCC vaccination in 2002...
November 23, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27876200/improving-adolescent-hpv-vaccination-in-a-randomized-controlled-cluster-trial-using-the-4-pillars%C3%A2-practice-transformation-program
#10
Richard K Zimmerman, Krissy K Moehling, Chyongchiou J Lin, Song Zhang, Jonathan M Raviotta, Evelyn C Reis, Sharon G Humiston, Mary Patricia Nowalk
OBJECTIVE: Uptake of meningococcal vaccine (MCV) and tetanus, diphtheria and pertussis (Tdap) vaccine among adolescents has approached Healthy People 2020 goals, but human papillomavirus (HPV) vaccination has not. This study evaluated an intervention using the 4 Pillars™ Practice Transformation Program to increase HPV, MCV and Tdap uptake among adolescents in primary care practices. METHODS: Practices with at least 50 patients 11-17years old with estimated vaccination rates less than national goals, were assigned to intervention (n=11) and control (n=11) groups in a randomized controlled cluster trial; 9 intervention and 11 control sites completed the study...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27876190/-bilateral-abducens-nerve-palsy-as-the-initial-clinical-manifestation-of-meningococcal-meningitis
#11
Ana Camacho Salas, Pablo Rojo Conejo, Noemí Núñez Enamorado, Rogelio Simón de Las Heras
No abstract text is available yet for this article.
November 18, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27869440/immunology-update-new-vaccines
#12
S Paul Starr
A new 9-valent human papillomavirus (HPV) vaccine is effective against more cancer-causing HPV types than previous vaccines. HPV vaccine series started with previous vaccines can be completed with the 9-valent vaccine. Two new influenza vaccines are available for adults 65 years and older: a high-dose vaccine and an enhanced adjuvant vaccine. These elicit stronger antibody responses than standard-dose vaccines. Current guidelines specify no preference for the new versus standard-dose vaccines. Two new group B meningococcal vaccines are intended for use during outbreaks and for patients with asplenia, complement deficiencies, frequent occupational meningococcus exposure, or for patients who desire protection from type B meningococcus...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27864913/human-secretory-igm-antibodies-activate-human-complement-and-offer-protection-at-mucosal-surface
#13
Terje E Michaelsen, Sidsel Emilsen, Randi H Sandin, Beathe Kiland Granerud, Diane Bratlie, Oistein Ihle, Inger Sandlie
IgM molecules circulate in serum as large polymers, mainly pentamers, which can be transported by the poly-Ig receptor (pIgR) across epithelial cells to mucosal surfaces and released as secretory IgM (SIgM). The mucosal SIgM molecules have non-covalently attached secretory component (SC), which is the extracellular part of pIgR which is cleaved from the epithelial cell membrane. Serum IgM antibodies do not contain SC, and have previously been shown to make a conformational change from "a star" to a "staple" conformation upon reaction with antigens on a cell surface, enabling them to activate complement...
November 16, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27861618/meningococcal-carriage-among-adolescents-after-mass-meningococcal-c-conjugate-vaccination-campaigns-in-salvador-brazil
#14
Amélia Maria Pithon Borges Nunes, Guilherme Sousa Ribeiro, Ítalo Eustáquio Ferreira, Ana Rafaela Silva Simões Moura, Ridalva Dias Martins Felzemburgh, Ana Paula Silva de Lemos, Mitermayer Galvão Reis, José Cassio de Moraes, Leila Carvalho Campos
Neisseria meningitidis is a commensal bacterium of the human nasopharynx. In rare cases, it penetrates the mucosa, entering the blood stream and causing various forms of disease. Meningococcal conjugate vaccines can prevent invasive disease not only by direct effect in vaccinated individuals but also by herd protection, preventing acquisition of carriage, which interrupts transmission and leads to protection of unvaccinated persons. In 2010 in Salvador, Brazil, an outbreak of group C meningococcal disease led to a mass meningococcal serogroup C conjugate vaccination drive, targeting those <5 and 10-24 years of age...
2016: PloS One
https://www.readbyqxmd.com/read/27855873/household-transmission-of-neisseria-meningitidis-in-the-african-meningitis-belt-a-longitudinal-cohort-study
#15
(no author information available yet)
BACKGROUND: Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe transmission patterns of Neisseria meningitidis (meningococcus) in households in the African meningitis belt. METHODS: Cross-sectional carriage surveys were done in seven African meningitis belt countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, and Oct 15, 2012. Meningococcal carriers identified in these surveys and all available people in their households were recruited into this longitudinal cohort study...
December 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27849512/a-fatal-case-of-invasive-infection-caused-by-w135-neisseria-meningitidis-in-a-vaccinated-french-soldier
#16
Sandrine Duron, Christophe Martinaud, David Lacassagne, Jean-Louis Koeck
We report on the case of fatal "purpura fulminans" caused by Neisseria meningitidis W135 that occurred in a young French soldier vaccinated a few months earlier with the tetravalent conjugate vaccine ACYW135. Biological investigations revealed adequate titers of postvaccination antibodies against serogroups A, C, and W135 and led to the post-mortem diagnosis of a complete C7 complement deficiency. Late complement component deficiency is a well-known risk factor of meningococcal diseases, but usually exposes to recurrent mild infections, whereas severe invasive meningococcal diseases are more likely to occur among properdin-deficient patients...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27847367/serum-bactericidal-antibody-responses-of-adults-immunized-with-the-menb-4c-vaccine-against-genetically-diverse-serogroup-b-meningococci
#17
Serena Giuntini, Eduardo Lujan, Malick M Gibani, Christina Dold, Christine S Rollier, Andrew J Pollard, Dan M Granoff
BACKGROUND: MenB-4C is a meningococcal vaccine for prevention of serogroup B disease. The vaccine contains Factor H binding protein (FHbp) and three other antigens that can elicit serum bactericidal activity (SBA). For vaccine licensure, efficacy was inferred from SBA responses against three indicator strains. The relation between the results and broad protection against circulating genetically diverse strains is not known. METHODS: 20 adults were immunized with two doses of MenB-4C given 1 to 2 months apart...
November 9, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27846061/neisseria-meningitidis-serogroup-b-vaccine-bivalent-rlp2086-induces-broad-serum-bactericidal-activity-against-diverse-invasive-disease-strains-including-outbreak-strains
#18
Shannon L Harris, Robert G K Donald, Julio Cesar Hawkins, Cuiwen Tan, Robert O'Neill, Lisa K McNeil, John L Perez, Annaliesa S Anderson, Kathrin U Jansen, Thomas R Jones
BACKGROUND: Bivalent rLP2086 (Trumenba®), 1 of 2 meningococcal serogroup B (MnB) vaccines recently approved in the United States for prevention of MnB disease in individuals aged 10-25 years, is composed of 2 lipidated factor H binding proteins (fHBPs) from subfamilies A and B. This study evaluated the breadth of MnB strain coverage elicited by bivalent rLP2086 measured with serum bactericidal assays using human complement (hSBAs). METHODS: hSBA responses to diverse MnB clinical strains circulating in the United States and Europe (n=23), as well as recent US university outbreak strains (n=4), were evaluated...
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27834532/honey-and-larvae-in-the-treatment-of-foot-gangrene-a-reflection
#19
Ruth Dickinson
With the introduction of the Nursing and Midwifery Council's (NMC) (2015a) revalidation directive, nurses are required to demonstrate an ongoing commitment to providing safe and effective care by continually combining sound empirical evidence with reflective practice ( Sackett et al, 1996 ; Rolfe et al, 2011 ). Using Gibbs' (1998) model, I will reflect on an episode of care undertaken while I was on a recent placement. This reflective account will discuss the clinical use of honey and larvae therapy in the treatment of foot gangrene following meningococcal septicaemia...
November 10, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27832151/nationwide-trends-in-bacterial-meningitis-before-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-burkina-faso-2011-2013
#20
Dinanibè Kambiré, Heidi M Soeters, Rasmata Ouédraogo-Traoré, Isaïe Medah, Lassana Sangare, Issaka Yaméogo, Guetawendé Sawadogo, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Lesley McGee, Velusamy Srinivasan, Flavien Aké, Malika Congo-Ouédraogo, Soufian Sanou, Absatou Ky Ba, Ryan T Novak, Chris Van Beneden
BACKGROUND: Following introduction of Haemophilus influenzae type b vaccine in 2006 and serogroup A meningococcal conjugate vaccine in 2010, Streptococcus pneumoniae (Sp) became the leading cause of bacterial meningitis in Burkina Faso. We describe bacterial meningitis epidemiology, focusing on pneumococcal meningitis, before 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the pediatric routine immunization program in October 2013. METHODS: Nationwide population-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results...
2016: PloS One
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