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https://www.readbyqxmd.com/read/29452028/meningococcal-disease-and-vaccination-knowledge-and-acceptability-among-adolescents-in-italy
#1
Concetta Paola Pelullo, Francesco Napolitano, Gabriella Di Giuseppe
This study aimed to evaluate the knowledge, attitudes and practice about invasive meningococcal disease and the relative vaccine for adolescent in Italy. A cross-sectional study was conducted from March to May 2017 among a sample of 771 adolescents in the geographic area of Naples (Italy). A self-administered anonymous questionnaire was used to collect demographics, knowledge about meningitis and preventive measures, perceived risk for contracting meningitis, attitude towards the utility of meningococcal vaccine, and adolescents' willingness to receive a meningococcal vaccine...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29450930/neonatal-meningococcal-disease
#2
Alhussain Aldabbagh, Rachel Webb, Lindsay Mildenhall, Emma Best
No abstract text is available yet for this article.
February 15, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29447987/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-soluble-immune-effector-molecules-ii-agents-targeting-interleukins-immunoglobulins-and-complement
#3
REVIEW
Kevin L Winthrop, Xavier Mariette, Jose T Silva, Esther Benamu, Leonard H Calabrese, Alexandre Dumusc, Josef S Smolen, José María Aguado, Mario Fernández-Ruiz
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of agents targeting interleukins, immunoglobulins and complement factors and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29446176/meningococcal-conjugate-vaccine-safety-surveillance-in-the-vaccine-safety-datalink-using-a-tree-temporal-scan-data-mining-method
#4
Rongxia Li, Eric Weintraub, Michael M McNeil, Martin Kulldorff, Edwin M Lewis, Jennifer Nelson, Stanley Xu, Lei Qian, Nicola P Klein, Frank Destefano
PURPOSE: The objective of our study was to conduct a data mining analysis to identify potential adverse events (AEs) following MENACWY-D using the tree-temporal scan statistic in the Vaccine Safety Datalink population and demonstrate the feasibility of this method in a large distributed safety data setting. METHODS: Traditional pharmacovigilance techniques used in vaccine safety are generally geared to detecting AEs based on pre-defined sets of conditions or diagnoses...
February 15, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29443825/maternal-influenza-immunization-and-prevention-of-severe-clinical-pneumonia-in-young-infants-analysis-of-randomized-controlled-trials-conducted-in-nepal-mali-and-south-africa
#5
Saad B Omer, Dayna R Clark, Anushka R Aqil, Milagritos D Tapia, Marta C Nunes, Naoko Kozuki, Mark C Steinhoff, Shabir A Madhi, Niteen Wairagkar
BACKGROUND: To evaluate the effect of antenatal influenza vaccination on all-cause severe infant pneumonia, we performed pooled analysis of three randomized-controlled trials conducted in Nepal, Mali, and South Africa. METHODS: The trials were coordinated from the planning phase. The follow-up period was 0-6 months post-partum in Nepal and Mali, and 0-24 weeks in South Africa. Pregnant women with gestational age 17-34 weeks in Nepal, ≥28 weeks in Mali, and 20-36 weeks in South Africa were enrolled...
February 13, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29441801/characterizing-the-meningococcal-glycointeractome-what-is-new
#6
Kate L Seib, Michael P Jennings, Christopher J Day
No abstract text is available yet for this article.
February 14, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29433138/-alert-for-meningitis-in-palermo-successful-strategies-to-counteract-the-impact-of-mass-media
#7
Gianmarco Ventura, Vincenzo Restivo, Claudio Costantino, Nicolò Casuccio, Claudio D'Angelo, Paola Stefanelli, Alessandra Casuccio, Francesco Vitale
Following two invasive meningococcal disease cases among twenties, general population overloaded vaccination Units of the Palermo's District during summer 2016. Sicilian Health Authorities adopted several public health strategies including: a) active meningococcal vaccination free of charge for people from 18 up to 30 years of age, b) information in crowded places and rapid communication by media. An increase in anti-meningococcal vaccination doses administered (+868%) as well as in anti-dTp and HPV vaccination (+41% and +8%, respectively) due to a further catch-up was observed...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29433128/-the-new-national-immunization-program-2017-2019-and-the-essential-care-levels-what-is-going-to-change
#8
Chiara De Waure, Leuconoe Grazia Sisti, Andrea Poscia, Walter Ricciardi
Italy is witnessing relevant challenges in the field of prevention and control of vaccine-preventable diseases. The worrying and growing phenomenon of "vaccine-hesitancy" has contributed to the reduction of vaccination coverage, undermining goals reached thanks to vaccines introduction. The new Italian National Immunization Plan (NIP) 2017-2019 and the update of the list of Essential Care Levels (LEA), approved in the current year, extend the vaccination offer based on the latest scientific evidence with the introduction of new vaccines and the enlargement of target population...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29432403/neutrophil-extracellular-traps-in-children-with-meningococcal-sepsis
#9
Tamara Hoppenbrouwers, Navin P Boeddha, Ebru Ekinci, Marieke Emonts, Jan A Hazelzet, Gertjan J Driessen, Moniek P de Maat
OBJECTIVES: Children with meningococcal sepsis are highly at risk for fulminant disease, multiple organ failure, and death. Recently, neutrophil extracellular traps levels have been indicated as a marker for severity in different kinds of sepsis. Our aim was to study the role of neutrophil extracellular traposis in meninogococcal sepsis in children. DESIGN: We measured myeloperoxidase-DNA, a marker for neutrophil extracellular traps, in serum of meningococcal sepsis patients upon admission to PICU, at 24 hours, and at 1 month and studied the association with clinical outcome...
February 9, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29428176/the-impact-of-immunization-programs-on-10-vaccine-preventable-diseases-in-italy-1900-2015
#10
Patrizio Pezzotti, Stefania Bellino, Francesca Prestinaci, Simone Iacchini, Francesca Lucaroni, Laura Camoni, Maria Maddalena Barbieri, Walter Ricciardi, Paola Stefanelli, Giovanni Rezza
BACKGROUND: Vaccination has determined a dramatic decline in morbidity and mortality from infectious diseases over the last century. However, low perceived risk of the infectious threat and increased concern about vaccines' safety led to a reduction in vaccine coverage, with increased risk of disease outbreaks. METHODS: Annual surveillance data of nationally communicable infectious diseases in Italy between 1900 and 2015 were used to derive trends in morbidity and mortality rates before and after vaccine introduction, focusing particularly on the effect of vaccination programs...
February 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29426659/current-status-of-cerebrospinal-meningitis-and-impact-of-the-2015-meningococcal-c-vaccination-in-kebbi-northwest-nigeria
#11
Olumide Ajibola, Semeeh Akinwale Omoleke, Olusola Akintoye Omisakin
INTRODUCTION: Following the significant reduction of Neisseria meningitidis A (NmA) in most parts of northern Nigeria, a new strain of Neisseria meningitidis C (NmC) emerged in 2013 causing outbreaks in the north and recently spreading to southern parts of the Nigeria. This study provides detailed epidemiological investigation in the last four years. METHODS: Analysis of confirmed and suspected cases of meningitis in Kebbi, Nigeria from 2014 to June 2017 detected through Integrated Disease Surveillance and Response...
February 6, 2018: Vaccine
https://www.readbyqxmd.com/read/29426026/lung-health-in-era-of-climate-change-and-dust-storms
#12
REVIEW
Michael D Schweitzer, Andrew S Calzadilla, Oriana Salamo, Arash Sharifi, Naresh Kumar, Gregory Holt, Michael Campos, Mehdi Mirsaeidi
Dust storms are strong winds which lead to particle exposure over extensive areas. These storms influence air quality on both a local and global scale which lead to both short and long-term effects. The frequency of dust storms has been on the rise during the last decade. Forecasts suggest that their incidence will increase as a response to the effects of climate change and anthropogenic activities. Elderly people, young children, and individuals with chronic cardiopulmonary diseases are at the greatest risk for health effects of dust storms...
February 6, 2018: Environmental Research
https://www.readbyqxmd.com/read/29420119/cross-protection-induced-by-va-mengoc-bc%C3%A2-vaccine
#13
Rolando Felipe Ochoa-Azze
I would like to comment on the article "Commentary: Impact of meningococcal group B OMV vaccines, beyond their brief", DOI: 10.1080/21645515.2017.1381810. The author states that meningococcal group B OMVs vaccines -such as VA-MENGOC-BC®- may induce moderate protection against Neisseria gonorrhoeae. I agree. However, the author states that "there was no evidence of effectiveness in the younger children." The effectiveness of VA-MENGOC-BC® in heterologous contexts has been higher than 80% in individuals older than 4 years old, but the effectiveness in younger children should not be undervalued; it has usually been higher than 60%, and results markedly higher when evaluated based on mortality rates...
February 8, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29414677/whole-genome-typing-of-the-recently-emerged-canadian-serogroup-w-neisseria-meningitidis-sequence-type-11-clonal-complex-isolates-associated-with-invasive-meningococcal-disease
#14
Raymond S W Tsang, Tauqeer Ahmad, Shaun Tyler, Brigitte Lefebvre, Shelley L Deeks, Rodica Gilca, Linda Hoang, Gregory Tyrrell, Paul Van Caeseele, Gary Van Domselaar, Frances B Jamieson
OBJECTIVE: We analyzed the Canadian invasive MenW ST-11 cc isolates by whole genome typing and compared Canadian isolates with similar isolates elsewhere. METHODS: Whole genome typing of 30 MenW ST-11 cc, 20 meningococcal group C (MenC) ST-11 cc and 31 MenW ST-22 cc isolates were carried out on the Bacterial Isolate Genome Sequence database platform. Canadian MenW ST-11 cc isolates were compared with the 2000 MenW Hajj outbreak strain, as well as with MenW ST-11 cc from other countries...
February 4, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29410413/crystal-structure-reveals-vaccine-elicited-bactericidal-human-antibody-targeting-a-conserved-epitope-on-meningococcal-fhbp
#15
Jacinto López-Sagaseta, Peter T Beernink, Federica Bianchi, Laura Santini, Elisabetta Frigimelica, Alexander H Lucas, Mariagrazia Pizza, Matthew J Bottomley
Data obtained recently in the United Kingdom following a nationwide infant immunization program against serogroup B Neisseria meningitidis (MenB) reported >80% 4CMenB vaccine-mediated protection. Factor H-binding protein (fHbp) is a meningococcal virulence factor and a component of two new MenB vaccines. Here, we investigated the structural bases underlying the fHbp-dependent protective antibody response in humans, which might inform future antigen design efforts. We present the co-crystal structure of a human antibody Fab targeting fHbp...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29409994/infectious-meningitis-and-encephalitis-in-adults-in-denmark-a-prospective-nationwide-observational-cohort-study-dasgib
#16
Jacob Bodilsen, Merete Storgaard, Lykke Larsen, Lothar Wiese, Jannik Helweg-Larsen, Anne-Mette Lebech, Christian Brandt, Christian Østergaard, Henrik Nielsen
OBJECTIVES: To monitor epidemiological trends of infectious meningitis (bacterial and viral) and encephalitis in Denmark. METHODS: Nation-wide prospective observational study of all cases with proven community-acquired infectious meningitis and encephalitis in adults treated in all departments of infectious diseases in Denmark from 1st of January 2015 to 30th of June 2016. We included data on symptoms, aetiology, treatment and outcome assessed by the Glasgow Outcome Scale (GOS) 30-days after discharge...
January 30, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29408359/meningitis-epidemics-shift-in-sub-saharan-belt
#17
Shi Zhao, Qianying Lin, Daihai He, Lewi Stone
Meningococcal meningitis (MCM) poses a serious threat to public health in Africa. Epidemics appear irregularly every 5-12 years, especially in regions across the sub-Saharan "meningitis belt". Here we investigate the long-term spatiotemporal dynamics of MCM, and report that "dominant epidemic outbreaks" appear to diffuse from west to east in this belt over the 2006-14 study period.
February 2, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29408188/a-retrospective-assessment-of-the-completeness-and-timeliness-of-meningococcal-disease-notifications-in-the-republic-of-ireland-over-a-16-year-period-1999-2015
#18
P O'Lorcain, D E Bennett, S L Morgan, R J Cunney, S M Cotter, M T Cafferkey, D M O'Flanagan
OBJECTIVES: To assess how invasive meningococcal disease (IMD) records held by the Irish Meningitis & Sepsis Reference Laboratory (IMSRL) compare to records of IMD notifications reported on the national integrated electronic Computerised Infectious Disease Reporting (CIDR) system. STUDY DESIGN: We assessed the completeness, data quality and timeliness of IMD notifications and reference laboratory records for the period between 01 July 1999 and 30 June 2015 by identifying discrepant and/or missing data items in a matched case data set and by measuring the timeliness of case reporting...
January 22, 2018: Public Health
https://www.readbyqxmd.com/read/29406154/meningococcal-disease-and-control-in-china-findings-and-updates-from-the-global-meningococcal-initiative-gmi
#19
REVIEW
Junhong Li, Zhujun Shao, Gang Liu, Xilian Bai, Ray Borrow, Min Chen, Qinglan Guo, Yue Han, Yixing Li, Muhamed-Kheir Taha, Xihai Xu, Xin Xu, Huizhen Zheng
The Global Meningococcal Initiative (GMI) is a global expert group, including scientists, clinicians and public health officials from a wide range of specialities. The goal of the GMI is to prevent meningococcal disease worldwide through education, research, and co-operation. The Chinese GMI roundtable meeting was held in June 2017. The GMI met with local experts to gain insight into the meningococcal disease burden in China and current prevention and vaccination strategies in place. China experienced five epidemics of serogroup A meningococcal disease (MenA) between 1938 and 1977, with peak incidence of 403/100,000 recorded in 1967...
January 31, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29398056/association-of-health-insurance-status-and-vaccination-coverage-among-adolescents-13-17-years-of-age
#20
Peng-Jun Lu, David Yankey, Jenny Jeyarajah, Alissa O'Halloran, Benjamin Fredua, Laurie D Elam-Evans, Sarah Reagan-Steiner
OBJECTIVE: To assess selected vaccination coverage among adolescents by health insurance status and other access-to-care characteristics. STUDY DESIGN: The 2015 National Immunization Survey-Teen data were used to assess vaccination coverage disparities among adolescents by health insurance status and other access-to-care variables. Multivariable logistic regression analysis and a predictive marginal modeling were conducted to evaluate associations between health insurance status and vaccination coverage...
February 2, 2018: Journal of Pediatrics
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