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https://www.readbyqxmd.com/read/29240724/large-outbreak-of-neisseria-meningitidis-serogroup-c-nigeria-december-2016-june-2017
#1
Chimeremma Nnadi, John Oladejo, Sebastian Yennan, Adesola Ogunleye, Chidinma Agbai, Lawal Bakare, Mohammed Abdulaziz, Amina Mohammed, Mary Stephens, Kyadindi Sumaili, Olivier Ronveaux, Helen Maguire, Debra Karch, Mahmood Dalhat, Martin Antonio, Andre Bita, Ifeanyi Okudo, Patrick Nguku, Ryan Novak, Omotayo Bolu, Faisal Shuaib, Chikwe Ihekweazu
On February 16, 2017, the Ministry of Health in Zamfara State, in northwestern Nigeria, notified the Nigeria Centre for Disease Control (NCDC) of an increased number of suspected cerebrospinal meningitis (meningitis) cases reported from four local government areas (LGAs). Meningitis cases were subsequently also reported from Katsina, Kebbi, Niger, and Sokoto states, all of which share borders with Zamfara State, and from Yobe State in northeastern Nigeria. On April 3, 2017, NCDC activated an Emergency Operations Center (EOC) to coordinate rapid development and implementation of a national meningitis emergency outbreak response plan...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29236639/a-bivalent-meningococcal-b-vaccine-in-adolescents-and-young-adults
#2
Lars Ostergaard, Timo Vesikari, Judith Absalon, Johannes Beeslaar, Brian J Ward, Shelly Senders, Joseph J Eiden, Kathrin U Jansen, Annaliesa S Anderson, Laura J York, Thomas R Jones, Shannon L Harris, Robert O'Neill, David Radley, Roger Maansson, Jean-Louis Prégaldien, John Ginis, Nina B Staerke, John L Perez
BACKGROUND: MenB-FHbp is a licensed meningococcal B vaccine targeting factor H-binding protein. Two phase 3 studies assessed the safety of the vaccine and its immunogenicity against diverse strains of group B meningococcus. METHODS: We randomly assigned 3596 adolescents (10 to 18 years of age) to receive MenB-FHbp or hepatitis A virus vaccine and saline and assigned 3304 young adults (18 to 25 years of age) to receive MenB-FHbp or saline at baseline, 2 months, and 6 months...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29236585/impact-of-meningococcal-c-conjugate-vaccination-programs-with-and-without-catch-up-campaigns-in-adolescents-lessons-learned-from-bahia-brazil
#3
Lara Evellyn do, Viviane Ferreira, Caroline Feitosa, Amelia Nunes, Leila Campos, Marco Aurélio P Sáfadi
The significant increase in the incidence rates and ongoing outbreaks of serogroup C meningococcal (MenC) disease, associated with the sequence type-103 complex, motivated the incorporation of the meningococcal C conjugate (MCC) vaccine in the routine immunization program in the State of Bahia, Brazil in early 2010, targeting children younger than 5 years of age. In its capital, Salvador, the program also included a catch-up campaign for individuals 10-24 years of age. We performed an observational, ecological study, analyzing data collected from 2007 to 2015, to compare the impact of these two immunization strategies on meningococcal disease incidence and mortality rates...
December 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29233459/invasive-meningococcal-disease-due-to-ciprofloxacin-resistant-neisseria-meningitidis-sequence-type-4821-the-first-case-in-japan
#4
Yu Kawasaki, Kousaku Matsubara, Hideyuki Takahashi, Masatomo Morita, Makoto Ohnishi, Masayuki Hori, Kenichi Isome, Aya Iwata, Hiroyuki Nigami, Mami Ikemachi, Go Yamamoto, Kiyofumi Ohkusu
We present a 4-year-old girl who developed invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup C sequence type (ST)-4821. She was hospitalized due to fever, vomiting, rash and altered consciousness. Serogroup C N. meningitidis was isolated from blood culture taken on admission and was confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a biochemical test, and molecular microbiological analysis. The patient was successfully treated with 50 mg/kg ceftriaxone every 12 hours for 7 days without any complications...
December 7, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29233288/student-pharmacists-perceptions-of-immunizations
#5
Kara Kubli, Sarah McBane, Jan D Hirsch, Sarah Lorentz
PURPOSE: The primary aim of this study was to explore changes in knowledge level, perceived importance and apprehension of immunizations by first year pharmacy students pre- vs. post-immunization education and training. EDUCATIONAL ACTIVITY: First year pharmacy students at the University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences (UC San Diego SSPPS) completed a pre- and post-immunization training course questionnaire. Knowledge base and perceived importance level of immunizations including hepatitis B, influenza, measles, mumps, rubella (MMR), varicella, tetanus, diphtheria, pertussis (Tdap), meningococcal and human papilloma virus (HPV) were assessed...
May 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29228283/interaction-of-neisseria-meningitidis-group-x-n-acetylglucosamine-1-phosphotransferase-with-its-donor-substrate
#6
Shonoi A Ming, Ebony Cottman-Thomas, Natalee C Black, Yi Chen, Vamsee Veeramachineni, Dwight C Peterson, Xi Chen, Lauren M Tedaldi, Gerd K Wagner, Chao Cai, Robert J Linhardt, Willie F Vann
Neisseria meningitidis Group X is an emerging cause of bacterial meningitis in the Sub-Saharan Africa. The capsular polysaccharide of Group X is a homopolymer of N-acetylglucosamine α(1-4) phosphate and is a vaccine target for prevention of disease associated with this meningococcal serogroup. We have demonstrated previously that the formation of the polymer is catalyzed by a phosphotransferase which transfers N- acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to the 4- hydroxyl of the N-acetylglucosamine on the non-reducing end of the growing chain...
December 8, 2017: Glycobiology
https://www.readbyqxmd.com/read/29227467/evidence-for-rise-in-meningococcal-serogroup-c-bactericidal-antibody-titers-in-the-absence-of-booster-vaccination-in-previously-vaccinated-children
#7
Al-Mamoon Badahdah, Ameneh Khatami, Mohamed Tashani, Harunor Rashid, Robert Booy
BACKGROUND: The introduction of meningococcal serogroup C (MenC) conjugate (MCC) vaccines in the UK and Australia led to an impressive decline in the incidence of invasive disease. This study examined bactericidal antibody titres over time in UK and Australian children who received a MCC vaccine in early childhood to test the hypothesis that ongoing boosting of immunity in the absence of further doses of vaccine in some children may contribute to ongoing protection from disease. METHODS: Serum bactericidal assay using rabbit complement (rSBA) titres at each follow-up visit were compared to all preceding visits to identify any ≥4-fold rise in titres...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29219762/establishing-the-critical-role-of-peripheral-blood-vessel-colonisation-by-neisseria-meningitidis-in-invasive-meningococcal-disease
#8
Ronan F O'Toole
In this issue of Virulence, Capel and colleagues describe the use of a unique humanised mouse model to elucidate specific interactions between Neisseria meningitidis and human endothelial cells during blood-borne infection in vivo. Here, a number of the key findings from their study and their implications for our understanding of invasive meningococcal disease are explored.
December 8, 2017: Virulence
https://www.readbyqxmd.com/read/29211624/vaccine-prevention-of-meningococcal-disease-in-africa-major-advances-remaining-challenges
#9
Mustapha M Mustapha, Lee H Harrison
Africa historically has had the highest incidence of meningococcal disease with high endemic rates and periodic epidemics. The meningitis belt, a region of sub-Saharan Africa extending from Senegal to Ethiopia, has experienced large, devastating epidemics. However, dramatic shifts in the epidemiology of meningococcal disease have occurred recently. For instance, meningococcal capsular group A (NmA) epidemics in the meningitis belt have essentially been eliminated by use of conjugate vaccine. However, NmW epidemics have emerged and spread across the continent since 2000; NmX epidemics have occurred sporadically, and NmC recently emerged in Nigeria and Niger...
December 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29208200/-primary-septic-arthritis-is-a-rare-atypical-manifestation-of-invasive-meningococcal-disease
#10
Anne Katrine Bisgaard, Steen Kåre Fagerberg, Ulla Hjort
We present a case report of a 50-year-old man diagnosed with a primary septic arthritis with invasive Neisseria meningitidis serogroup W (MenW) clonal complex 11 identified with culture in blood and synovial fluid. The patient recovered from rapidly instituted relevant antibiotics and synovectomy, but there may be a risk of fatal delayed diagnosis and treatment by an atypical manifestation of invasive meningococcal disease. Invasive MenW disease has been increasing in recent years and has been described with atypical presentations...
November 27, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29207945/meningococcal-arthritis-and-myopericarditis-a-case-report
#11
Lloyd Steele, Katie Bechman, Eoghan De Barra, Charles Mackworth-Young
BACKGROUND: We report the first adult case of Neisseria meningitidis W-135 presenting with meningococcal arthritis and myopericarditis concomitantly, without other classical features of meningococcal disease. CASE PRESENTATION: A 67-year-old Caucasian man presented with acute-onset polyarthralgia, myalgia, and fever. On examination he had polyarticular synovitis. An electrocardiogram (ECG) demonstrated ST-elevation in leads I, II, III, aVF, and V2-V6 without reciprocal depression, and a high-sensitivity troponin level was significantly elevated...
December 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29203096/meningococcal-disease-a-clinical-and-epidemiological-review
#12
REVIEW
Rodrigo Siqueira Batista, Andréia Patrícia Gomes, Jorge Luiz Dutra Gazineo, Paulo Sérgio Balbino Miguel, Luiz Alberto Santana, Lisa Oliveira, Mauro Geller
Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29202798/intention-to-vaccinate-universally-against-varicella-rotavirus-gastroenteritis-meningococcal-b-disease-and-seasonal-influenza-among-parents-in-the-netherlands-an-internet-survey
#13
Alies van Lier, José A Ferreira, Liesbeth Mollema, Elisabeth A M Sanders, Hester E de Melker
OBJECTIVE: For the decision-making process regarding introduction of new vaccines into the National Immunisation Programme (NIP), advance insight into the potential acceptance among the population is relevant. We studied the intention of parents to have their child vaccinated against four diseases not currently covered by the NIP in the Netherlands. The results on varicella have been published before; this article adds the results on vaccination against rotavirus gastroenteritis, meningococcal B disease, and seasonal influenza...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29200041/meningococcal-disease-vaccines-who-s-at-risk-and-the-future
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/29200035/meningococcal-disease-vaccines-who-s-at-risk-and-the-future
#15
Patricia Anne O'Malley
No abstract text is available yet for this article.
January 2018: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/29197599/meningococcal-carriage-within-households-in-the-african-meningitis-belt-a-longitudinal-pilot-study
#16
Nicole E Basta, Abdoulaye Berthe, Mahamadou Keita, Uma Onwuchekwa, Boubou Tamboura, Awa Traore, Musa Hassan-King, Olivier Manigart, Maria Nascimento, James M Stuart, Caroline Trotter, Jayne Blake, Anthony D Carr, Stephen J Gray, Lynne S Newbold, Yangqing Deng, Julian Wolfson, M Elizabeth Halloran, Brian Greenwood, Ray Borrow, Samba O Sow
OBJECTIVES: Carriers of Neisseria meningitidis are a key source of transmission. In the African meningitis belt, where risk of meningococcal disease is highest, a greater understanding of meningococcal carriage dynamics is needed. METHODS: We randomly selected an age-stratified sample of 400 residents from 116 households in Bamako, Mali, and collected pharyngeal swabs in May 2010. A month later, we enrolled all 202 residents of 20 of these households (6 with known carriers) and collected swabs monthly for 6 months prior to MenAfriVac vaccine introduction and returned 10 months later to collect swabs monthly for 3 months...
November 29, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29194013/public-policy-for-meningococcal-vaccination
#17
J Claire Cameron
No abstract text is available yet for this article.
December 1, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29194010/impact-of-serogroup-a-meningococcal-conjugate-vaccine-for-africa
#18
James M Stuart
The introduction of a serogroup A meningococcal conjugate vaccine in the African meningitis belt has been a remarkable success. Meningitis due to the serogroup A meningococcus, previously responsible for most epidemics, has fallen by 99% in vaccinated countries. Success must, however, not distract from the continuing burden of meningitis in this region of Africa. The number of all meningitis epidemics at health district level has fallen by 60% following vaccination, but epidemics due to other meningococcal serogroups continue and may be increasing...
December 1, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29187601/efficient-solid-phase-synthesis-of-meningococcal-capsular-oligosaccharides-enables-simple-and-fast-chemoenzymatic-vaccine-production
#19
Timm Fiebig, Christa Litschko, Friedrich Freiberger, Andrea Bethe, Monika Berger, Rita Gerardy-Schahn
Neisseria meningitidis serogroups A (NmA) and X (NmX) are among the leading causes of bacterial meningitis in the African meningitis belt. Glycoconjugate vaccines, consisting of an antigenic carrier protein coupled to the capsular polysaccharide of the bacterial pathogen, are the most effective strategy for prevention of meningococcal disease. However, the distribution of effective glycoconjugate vaccines in this region is limited by high cost of cultivating pathogens and purification of their capsular polysaccharides...
November 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29183735/meningococcal-carriage-among-a-university-student-population-united-states-2015
#20
Lucy Breakwell, Melissa Whaley, Unab I Khan, Utpala Bandy, Nicole Alexander-Scott, Lynn Dupont, Cindy Vanner, How-Yi Chang, Jeni T Vuong, Stacey Martin, Jessica R MacNeil, Xin Wang, Sarah A Meyer
OBJECTIVES: Several outbreaks of serogroup B meningococcal disease have occurred among university students in recent years. In the setting of high coverage of the quadrivalent meningococcal conjugate vaccine and prior to widespread use of serogroup B meningococcal vaccines among adolescents, we conducted surveys to characterize the prevalence and molecular characteristics of meningococcal carriage among university students. METHODS: Two cross-sectional oropharyngeal carriage surveys were conducted among undergraduates at a Rhode Island university...
November 25, 2017: Vaccine
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