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https://www.readbyqxmd.com/read/28813690/deep-coal-mining-and-meningococcal-meningitis-in-england-and-wales-1931-38-ecological-study-with-implications-for-deep-shaft-mining-activities-worldwide
#1
Matthew R Smallman-Raynor, Andrew D Cliff
The hypothesized role of deep coal mining in the development of community-based outbreaks of meningococcal meningitis has gone largely unexplored. Taking the coalfields of Britain as a historical testbed, techniques of linear and binomial logistic regression were used to assess the association between meningococcal meningitis rates and male occupation rates for coal mining in England and Wales during the national epidemic of 1931-32 and in its aftermath. Adjusting for the epidemiological effects of age, residential density, recent changes in the number of families, housing stock and low social class, the analysis yielded evidence of a significant and positive association between coal mining occupation rates and notified levels of meningitis activity in the epidemic period...
August 13, 2017: Health & Place
https://www.readbyqxmd.com/read/28808592/a-case-of-fulminant-meningococcemia-it-is-all-in-the-complement
#2
Kellie L Hawkins, Mariah Hoffman, Sonia Okuyama, Sarah E Rowan
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28807957/emerging-clone-of-meningococcal-bacterium-affecting-middle-aged-and-older-adults
#3
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28802678/gonococcal-vaccine-development-lessons-from-group-b-meningococcal-vaccines
#4
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28801959/outcomes-of-patients-with-atypical-hemolytic-uremic-syndrome-with-native-and-transplanted-kidneys-treated-with-eculizumab-a-pooled-post-hoc-analysis
#5
Christophe M Legendre, Josep M Campistol, Thorsten Feldkamp, Giuseppe Remuzzi, John F Kincaid, Åsa Lommelé, Jimmy Wang, Laurent E Weekers, Neil S Sheerin
Atypical hemolytic uremic syndrome (aHUS) often leads to end-stage renal disease (ESRD) and kidney transplantation; graft loss rates are high due to disease recurrence. A post hoc analysis of four prospective clinical trials in aHUS was performed to evaluate eculizumab, a terminal complement inhibitor, in patients with native or transplanted kidneys. The trials included 26-week treatment and extension periods. Dialysis, transplant, and graft loss were evaluated. Study endpoints included complete thrombotic microangiopathy (TMA) response, TMA event-free status, hematologic and renal parameters, and adverse events...
August 12, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28801740/a-statistical-classifier-to-support-diagnose-meningitis-in-less-developed-areas-of-brazil
#6
Viviane-Maria Lélis, Eduardo Guzmán, María-Victoria Belmonte
This paper describes the development of statistical classifiers to help diagnose meningococcal meningitis, i.e. the most sever, infectious and deadliest type of this disease. The goal is to find a mechanism able to determine whether a patient has this type of meningitis from a set of symptoms that can be directly observed in the earliest stages of this pathology. Currently, in Brazil, a country that is heavily affected by meningitis, all suspected cases require immediate hospitalization and the beginning of a treatment with invasive tests and medicines...
August 11, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28796795/investigation-of-correlates-of-protection-against-pharyngeal-carriage-of-neisseria-meningitidis-genogroups-w-and-y-in-the-african-meningitis-belt
#7
Laura V Cooper, Rahamatou Moustapha Boukary, Abraham Aseffa, Wude Mihret, Jean-Marc Collard, Doumagoum Daugla, Abraham Hodgson, Cheikh Sokhna, Babatunji Omotara, Samba Sow, Stephen Laryea Quaye, Kanny Diallo, Olivier Manigart, Martin C J Maiden, Helen Findlow, Ray Borrow, James M Stuart, Brian M Greenwood, Caroline L Trotter
BACKGROUND: Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. METHODS: Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey...
2017: PloS One
https://www.readbyqxmd.com/read/28794096/an-increase-in-accident-and-emergency-presentations-for-adverse-events-following-immunisation-after-introduction-of-the-group-b-meningococcal-vaccine-an-observational-study
#8
Viveka Nainani, Ushma Galal, Jim Buttery, Matthew D Snape
OBJECTIVES: To determine whether the introduction of the capsular group B meningococcal vaccine (4CMenB) in the UK has increased presentations of infants to emergency departments with adverse events following immunisation (AEFI). PARTICIPANTS, DESIGN AND SETTING: A retrospective review of hospital records of infants aged 1-6 months presenting to Oxford University Hospitals NHS Trust's emergency departments from September 2013 to August 2016 with discharge diagnoses of vaccine reactions or non-specific conditions...
August 9, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28794055/effect-of-vaccine-elicited-antibodies-on-colonization-of-neisseria-meningitidis-serogroup-b-and-c-strains-in-a-human-bronchial-epithelial-cell-culture-model
#9
Vianca Vianzon, Beate Illek, Gregory R Moe
Capsular polysaccharide-protein conjugate vaccines protect individuals from invasive disease and decrease carriage, which reduces spread of the organism in the population. In contrast, antibodies elicited by plain polysaccharide or protein antigen-based meningococcal (Men) vaccines have little or no effect on decreasing carriage. In this study, we investigated the mechanism by which vaccine-induced human IgG antibodies affect colonization by serogroup B (MenB) or C (MenC) strains using a human bronchial epithelial cell culture model (16HBE14o-)...
August 9, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28776217/neck-injury-and-conjunctival-petechiae-in-a-woman-who-underwent-cardiopulmonary-resuscitation-and-subsequently-died-from-meningococcal-sepsis
#10
Jack Garland, Rexson Tse
Cardiopulmonary resuscitation (CPR) can create a range of unusual lesions and injuries, which may complicate forensic evaluation. Although potentially sinister findings, neck injury and conjunctival petechiae may also be seen in patients who have undergone CPR. We report a case of an individual with subcutaneous bruising and hemorrhage in the deep structures of the neck and florid conjunctival petechiae at autopsy that can be explained by cardiopulmonary resuscitation and meningococcal sepsis.
August 3, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28771457/meningitis-outbreak-caused-by-vaccine-preventable-bacterial-pathogens-northern-ghana-2016
#11
Fortress Y Aku, Fernanda C Lessa, Franklin Asiedu-Bekoe, Phoebe Balagumyetime, Winfred Ofosu, Jennifer Farrar, Mahamoudou Ouattara, Jeni T Vuong, Kofi Issah, Joseph Opare, Sally-Ann Ohene, Charles Okot, Ernest Kenu, Donne K Ameme, David Opare, Abass Abdul-Karim
Bacterial meningitis is a severe, acute infection of the fluid surrounding the brain and spinal cord that can rapidly lead to death. Even with recommended antibiotic treatment, up to 25% of infected persons in Africa might experience neurologic sequelae (1). Three regions in northern Ghana (Upper East, Northern, and Upper West), located in the sub-Saharan "meningitis belt" that extends from Senegal to Ethiopia, experienced periodic outbreaks of meningitis before introduction of serogroup A meningococcal conjugate vaccine (MenAfriVac) in 2012 (2,3)...
August 4, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28770496/serogroup-b-meningococcus-outbreaks-prevalence-and-the-case-for-standard-vaccination
#12
REVIEW
James Grogan, Karen Roos
PURPOSE OF REVIEW: This review explores the history of serogroup B meningitis outbreaks in American universities and the rise of the monovalent serogroup B meningococcus vaccines (MenB). RECENT FINDINGS: Serogroup B meningitis represents 30% of American meningococcal infections and had no commercially available vaccine in the USA until 2013 when the FDA made an expanded allowance for importation of the MenB-4C vaccine for outbreaks at two American universities. Infections of Neisseria meningitidis, notably meningococcal meningitis represent a continued, lethal threat to the pediatric and adolescent populations and those with primary or acquired complement component deficiencies, largely mitigated by the quadrivalent meningococcal conjugated vaccine against serogroups A, C, W, and Y (MenACWY)...
September 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28770026/neisseria-lactamica-y92-1009-complete-genome-sequence
#13
Anish K Pandey, David W Cleary, Jay R Laver, Martin C J Maiden, Xavier Didelot, Andrew Gorringe, Robert C Read
We present the high quality, complete genome assembly of Neisseria lactamica Y92-1009 used to manufacture an outer membrane vesicle (OMV)-based vaccine, and a member of the Neisseria genus. The strain is available on request from the Public Health England Meningococcal Reference Unit. This Gram negative, dipplococcoid bacterium is an organism of worldwide clinical interest because human nasopharyngeal carriage is related inversely to the incidence of meningococcal disease, caused by Neisseria meningitidis. The organism sequenced was isolated during a school carriage survey in Northern Ireland in 1992 and has been the subject of a variety of laboratory and clinical studies...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28769927/novel-intervention-in-the-aging-population-a-primary-meningococcal-vaccine-inducing-protective-igm-responses-in-middle-aged-adults
#14
Marieke van der Heiden, Annemieke M H Boots, Axel A Bonacic Marinovic, Lia G H de Rond, Marjan van Maurik, Irina Tcherniaeva, Guy A M Berbers, Anne-Marie Buisman
INTRODUCTION: Vaccine responses are often reduced in the elderly, leaving part of the elderly population vulnerable to infectious diseases. Timely vaccination may offer a solution for strengthening memory immunity before reaching old age, which classifies middle-aged persons as a target age group for vaccine interventions. However, knowledge regarding the immunogenicity of primary immunizations in middle-aged adults is lacking. We determined the immunogenicity of a primary meningococcal vaccine towards which no or (very) low pre-vaccination immunity exists in middle-aged adults (NTR4636)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28767667/uptake-of-a-new-meningitis-vaccination-programme-amongst-first-year-undergraduate-students-in-the-united-kingdom-a-cross-sectional-study
#15
Sarah Blagden, Daniel Seddon, Daniel Hungerford, Debbi Stanistreet
BACKGROUND: In 2015 meningococcal group W was declared endemic in the UK, with the meningococcal ACWY vaccination (MenACWY) subsequently introduced amongst adolescents and first-year university students. This study aimed to determine MenACWY uptake amongst students and to evaluate how this was influenced by demographics and via the Health Belief Model (HBM). METHODS: This was a cross-sectional study conducted at a British university amongst first-year undergraduate students aged 18-25 years...
2017: PloS One
https://www.readbyqxmd.com/read/28760613/who-position-paper-meningococcal-a-conjugate-vaccine-updated-guidance-february-2015
#16
World Health Organization
This article presents the World Health Organization's (WHO) updated recommendations on the use of meningococcal vaccines excerpted from the WHO position paper on Meningococcal A conjugate vaccine: updated guidance, February 2015, published in the Weekly Epidemiological Record [1]. A position paper on meningococcal vaccines was published in 2011 and its recommendations remain valid [2]. This update adds to the previous recommendations specifically concerning routine immunization of infants and young children in the African meningitis belt with meningococcal A conjugate vaccine...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28760611/chronically-ill-adolescents-are-also-incompletely-vaccinated-a-cross-sectional-study-in-france
#17
Christèle Gras-Le Guen, Arnaud Legrand, Marylène Caquard, Xavier Micaelli, Georges Picherot, Sylvie Lacroix, Christelle Volteau, Elise Launay
BACKGROUND: Adolescent vaccination coverage tends to be suboptimal, leading to resurgent infectious pathologies and vulnerability to various pathogens. The low frequency of medical consultations and missed opportunities for vaccination are often used to explain the low rate of vaccination. The aim of this study was to assess if the vaccination coverage rate is higher in chronically ill adolescents (CIA) who require a close pediatric specialized follow-up versus the rate in healthy adolescents (HA)...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28749333/a-cluster-of-invasive-meningococcal-disease-imd-caused-by-neisseria-meningitidis-serogroup-w-among-university-students-france-february-to-may-2017
#18
Clément Bassi, Muhamed-Kheir Taha, Christian Merle, Eva Hong, Daniel Lévy-Bruhl, Anne-Sophie Barret, Ibrahim Mounchetrou Njoya
Between February and May 2017, two cases of invasive meningococcal disease caused by a new, rapidly expanding serogroup W meningococci variant were reported among students of an international university in Paris. Bacteriological investigations showed that isolates shared identical genotypic formula (W:P1.5,2:F1-1:cc11) and belonged to the South American/UK lineage. A vaccination campaign was organised that aimed at preventing new cases linked to potential persistence of the circulation of the bacteria in the students...
July 13, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28745253/-gastrointestinal-symptoms-with-meningococcal-infection-emergence-of-neisseria-meningitidis-serogroup-w
#19
H F Wunderink, I N Vlasveld, M J Knol, A van der Ende, E H R van Essen, E J Kuijper
BACKGROUND: Meningococcal disease usually presents as meningitis and/or septicaemia, but can also present as pneumonia or arthritis. Since 2000, a worldwide increase in meningococcal disease is reported which is caused by a new virulent clone of serogroup W (MenW:cc11). This subtype is more likely to give an atypical clinical presentation and results in high mortality rates. CASE DESCRIPTION: A 68-year-old woman with polymyalgia rheumatica, managed with prednisone, developed an acute gastrointestinal syndrome of nausea, diarrhoea, vomiting, fever and chills...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28742866/contribution-of-factor-h-binding-protein-sequence-to-the-cross-reactivity-of-meningococcal-native-outer-membrane-vesicle-vaccines-with-over-expressed-fhbp-variant-group-1
#20
Arianna Marini, Omar Rossi, Maria Grazia Aruta, Francesca Micoli, Simona Rondini, Serafina Guadagnuolo, Isabel Delany, Ian R Henderson, Adam F Cunningham, Allan Saul, Calman A MacLennan, Oliver Koeberling
Factor H-binding protein (fHbp) is an important meningococcal vaccine antigen. Native outer membrane vesicles with over-expressed fHbp (NOMV OE fHbp) have been shown to induce antibodies with broader functional activity than recombinant fHbp (rfHbp). Improved understanding of this broad coverage would facilitate rational vaccine design. We performed a pair-wise analysis of 48 surface-exposed amino acids involved in interacting with factor H, among 383 fHbp variant group 1 sequences. We generated isogenic NOMV-producing meningococcal strains from an African serogroup W isolate, each over-expressing one of four fHbp variant group 1 sequences (ID 1, 5, 9, or 74), including those most common among invasive African meningococcal isolates...
2017: PloS One
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