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https://www.readbyqxmd.com/read/28100689/effectiveness-and-duration-of-protection-of-one-dose-of-a-meningococcal-conjugate-vaccine
#1
Amanda C Cohn, Jessica R MacNeil, Lee H Harrison, Ruth Lynfield, Arthur Reingold, William Schaffner, Elizabeth R Zell, Brian Plikaytis, Xin Wang, Nancy E Messonnier
BACKGROUND: Meningococcal conjugate vaccines were licensed beginning in 2005 on the basis of serologic end points and recommended for use in adolescents. A single dose at age 11 to 12 years was expected to provide protection through late adolescence. We conducted a case-control evaluation of vaccine effectiveness (VE) and duration of protection of a meningococcal (groups A, C, W, and Y) polysaccharide diphtheria toxoid conjugate vaccine (MenACWY-D). METHODS: Cases of culture- or polymerase chain reaction-confirmed serogroup A, C, W, and Y meningococcal disease among adolescents were identified through meningococcal disease surveillance sites in the United States from January 1, 2006, through August 31, 2013...
January 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28100432/effectiveness-and-impact-of-a-reduced-infant-schedule-of-4cmenb-vaccine-against-group-b-meningococcal-disease-in-england-a-national-observational-cohort-study
#2
Sydel R Parikh, Nick J Andrews, Kazim Beebeejaun, Helen Campbell, Sonia Ribeiro, Charlotte Ward, Joanne M White, Ray Borrow, Mary E Ramsay, Shamez N Ladhani
BACKGROUND: In September, 2015, the UK became the first country to introduce the multicomponent group B meningococcal (MenB) vaccine (4CMenB, Bexsero) into a publicly funded national immunisation programme. A reduced two-dose priming schedule was offered to infants at 2 months and 4 months, alongside an opportunistic catch-up for 3 month and 4 month olds. 4CMenB was predicted to protect against 73-88% of MenB strains. We aimed to assess the effectiveness and impact of 4CMenB in vaccine-eligible infants in England...
December 3, 2016: Lancet
https://www.readbyqxmd.com/read/28099125/meningococcal-acwy-vaccine-uptake-and-awareness-among-student-freshers-enrolled-at-northern-ireland-universities
#3
Peter J A Moore, B Cherie Millar, John E Moore
A new MenACWY conjugate meningococcal vaccination programme was introduced in Northern Ireland (NI) in August 2015, for 13-18 year olds, as well as for first-time university entrants up to 25 years. This reflected the response made by Public Health England, due to the recent rapid increase of meningococcal group W (MenW) disease and on advice of the UK Joint Committee on Vaccination and Immunisation (JCVI). The aims of this study were to evaluate (i) the uptake of the MenACWY vaccine among first-time university students, (ii) vaccine and meningitis awareness, (iii) optimal communication modalities via a multidisciplinary team (MDT) model and (iv) current international vaccination policies relating to non-UK students...
January 18, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28081260/comparative-genome-sequencing-reveals-within-host-genetic-changes-in-neisseria-meningitidis-during-invasive-disease
#4
Johanna Klughammer, Marcus Dittrich, Jochen Blom, Vera Mitesser, Ulrich Vogel, Matthias Frosch, Alexander Goesmann, Tobias Müller, Christoph Schoen
Some members of the physiological human microbiome occasionally cause life-threatening disease even in immunocompetent individuals. A prime example of such a commensal pathogen is Neisseria meningitidis, which normally resides in the human nasopharynx but is also a leading cause of sepsis and epidemic meningitis. Using N. meningitidis as model organism, we tested the hypothesis that virulence of commensal pathogens is a consequence of within host evolution and selection of invasive variants due to mutations at contingency genes, a mechanism called phase variation...
2017: PloS One
https://www.readbyqxmd.com/read/28079790/ecthyma-gangrenosum-a-skin-manifestation-of-pseudomonas-aeruginosa-sepsis-in-a-previously-healthy-child-a-case-report
#5
Stephanie Biscaye, Diane Demonchy, Mickael Afanetti, Audrey Dupont, Herve Haas, Antoine Tran
RATIONALE: Ecthyma gangrenosum (Eg) is a necrotic lesion that is mostly seen in immunocompromised patients. It reflects a severe sepsis, possibly caused by Pseudomonas aeruginosa (Pa). PATIENT CONCERNS: A healthy 3-year-old girl admitted to the Pediatric Emergency Department presented a sepsis-associated purpura with neurological and respiratory distress. INTERVENTIONS: An empiric antibiotherapy (anti-meningococcal) was prescribed. DIAGNOSES: Forty-eight hours after admission, blood and wound cultures were positive for Pa...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072958/-investigation-on-immunization-program-coverage-rate-and-its-safety-in-children-with-tuberous-sclerosis
#6
Y Gao, L P Zou, M N Zhang, L Y Pang, Y Y Wang, S F Ma, L L Huang
Objective: To investigate the status of immunization of National Immunization Program (NIP) and its adverse reaction rate in children with tuberous sclerosis. Method: Questionnaire survey was adopted to identify the vaccination coverage and its adverse events; 72 cases of children with tuberous sclerosis and 78 normal controls (healthy children completing age-appropriate NIP) admitted to Chinese People's Liberation Army General Hospital from December 2014 to November 2015 were involved into this study. Result: The age-appropriate NIP coverage rate of tuberous sclerosis was 36%(26/72)...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28069783/secondary-asplenia-as-a-complication-of-severe-meningococcal-sepsis
#7
Lourdes Castillo-Campos, Luis Bachiller-Carnicero, María José Megía-Sevilla, María Isabel González-Tomé
We report the case of an 11-month-old infant who had a medical history of meningococcal septicaemia 6 months prior to this admission and presented to hospital with an episode of fever due to Streptococcus pneumoniae bacteraemia. During this second admission, an abdominal ultrasound scan revealed secondary asplenia.
January 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28057112/-analysis-for-protection-rate-and-antibody-levels-of-epidemic-cerebrospinal-meningitis-among-children-aged-between-3-23-months-in-liuzhou-in-2012
#8
X L Cui, X Wu, M Q Li
Objective: To understand the level of bactericidal antibodies against Neisseria meningitidis and their rate of protection in children aged between 3 and 23 months, in Liuzhou, in 2012. Methods: Convenience sampling was performed in Liujiang, Rong'an and Sanjiang Counties from May through August, 2012. The inclusion criteria for 603 subjects were: Children aged between 3 and 23 months; no history of meningococcal meningitis; no vaccination against Neisseria meningitidis serogroup C; more than 30 days from the last vaccination against Neisseria meningitidis serogroup A...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28043234/australian-meningococcal-surveillance-programme-1-july-to-30-september-2016
#9
Monica M Lahra, Rodney P Enriquez
No abstract text is available yet for this article.
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043225/australian-meningococcal-surveillance-programme-annual-report-2015
#10
Monica M Lahra, Rodney P Enriquez
In 2015, there were 174 laboratory-confirmed cases of invasive meningococcal disease analysed by the Australian National Neisseria Network. This number was higher than that reported in 2013 and 2014, which were the lowest and second-lowest totals reported, respectively, since inception of the Australian Meningococcal Surveillance Programme in 1994. Probable and laboratory confirmed invasive meningococcal disease (IMD) is notifiable in Australia. There were 182 IMD cases notified to the National Notifiable Diseases Surveillance System in 2015, again, higher than in 2013 and 2014, which were the lowest and second-lowest totals of IMD cases recorded, respectively, by this system...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043219/rise-in-invasive-serogroup-w-meningococcal-disease-in-australia-2013-2015
#11
Nicolee V Martin, Katherine S Ong, Benjamin P Howden, Monica M Lahra, Stephen B Lambert, Frank H Beard, Gary K Dowse, Nathan Saul
Since 2013, there has been an increase in the number of notified cases of invasive meningococcal disease (IMD) due to serogroup W (MenW) in Australia. In response to this observed increase, the Communicable Diseases Network Australia convened a working group in 2015 to collate and analyse the epidemiology of MenW disease nationally. Enhanced surveillance data collected by jurisdictions were collated and analysed, and whole genome sequencing (WGS) of MenW isolates assessed the genomic relatedness of strains between 2012 and 2015...
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28043218/rise-in-invasive-serogroup-w-meningococcal-disease-in-australia-2013-2015
#12
EDITORIAL
Mark Gk Veitch, Rhonda L Owen
No abstract text is available yet for this article.
December 24, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28039342/meningococcal-disease-has-the-battle-been-won
#13
REVIEW
Beverley C Millar, P J A Moore, J E Moore
Meningococcal disease is a worldwide life-threatening infection associated in many cases with debilitating long-term sequelae, both within the military and civilian populations. Military recruits are at a higher risk of acquiring this infection due to numerous factors, such as young recruits in the age group 18-25 years, high carriage rates of meningococci, communal and crowed living quarters and global deployment or training in regions with different meningococcal serogroup epidemiology. Although these increased risk factors among young recruits remain, the increased incidence of disease is now historic...
December 30, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28038948/-immunisation-schedule-of-the-spanish-association-of-paediatrics-2017-recommendations
#14
David Moreno-Pérez, Francisco José Álvarez García, Javier Arístegui Fernández, María José Cilleruelo Ortega, José María Corretger Rauet, Nuria García Sánchez, Ángel Hernández Merino, Teresa Hernández-Sampelayo Matos, Manuel Merino Moína, Luis Ortigosa Del Castillo, Jesús Ruiz-Contreras
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV- AEP) annually publishes the immunisation schedule which, in our opinion, is considered optimal for children resident in Spain, taking into account the evidence available on current vaccines. Pneumococcal and varicella immunisation in early childhood is already included in all funded vaccines present in the regional immunisation programmes. Furthermore, this committee establishes recommendations on vaccines not included in official calendars (non-funded immunisations), such as rotavirus, meningococcal B, and meningococcal ACWY...
December 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28030524/attitudes-of-swiss-health-care-providers-towards-childhood-immunizations
#15
Marianne Schuler, Sabine Schaedelin, Christoph Aebi, Christoph Berger, Pierre-Alex Crisinel, Alessandro Diana, Anita Niederer-Loher, Claire-Anne Siegrist, Bernard Vaudaux, Ulrich Heininger
BACKGROUND: INFOVAC is a network providing information about immunization issues to health professionals. The aim of this study was to assess the attitude of INFOVAC subscribers towards the current Swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. METHODS: In March 2015, a web-based survey was sent to 4260 physicians and pharmacists subscribed to INFOVAC. Participation was anonymous and voluntary...
December 27, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28029540/use-of-a-booster-dose-of-capsular-group-c-meningococcal-glycoconjugate-vaccine-to-demonstrate-immunologic-memory-in-children-primed-with-one-or-two-vaccine-doses-in-infancy
#16
David Pace, Ameneh Khatami, Simon Attard-Montalto, Merryn Voysey, Adam Finn, Saul N Faust, Paul T Heath, Ray Borrow, Matthew D Snape, Andrew J Pollard
BACKGROUND: Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have demonstrated their ability to distinguish primed from unprimed children. METHODS: This study was part of a randomised controlled trial investigating the immunogenicity of a booster dose of the combined Haemophilus influenzae type b and MenC-tetanus toxoid vaccine (Hib-MenC-TT) in infants receiving reduced dose MenCC vaccine priming schedules (one MenC-CRM/MenC-TT or two MenC-CRM vaccine doses) compared with an unprimed group...
October 28, 2016: Vaccine
https://www.readbyqxmd.com/read/28027288/cost-effectiveness-comparison-of-monovalent-c-versus-quadrivalent-acwy-meningococcal-conjugate-vaccination-in-canada
#17
Philippe De Wals, Zhou Zhou
BACKGROUND: In Quebec, one dose of monovalent C meningococcal conjugate vaccine (Men-C-Con) is offered at 12 months of age and a booster dose in grade 9 (14-15 years of age). In other Canadian provinces, a quadrivalent ACWY vaccine (Men-4-Con) is increasingly used for adolescents. An economic analysis was performed to assess the value of a switch from Men-C-Con to Men-4-Con. METHODS: A compartmental static simulation model was developed to assess the burden of AWY invasive meningococcal disease (IMD) in a cohort of 100,000 persons with different vaccination programs...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28025240/safety-of-quadrivalent-meningococcal-conjugate-vaccine-in-11-to-21-year-olds
#18
Hung-Fu Tseng, Lina S Sy, Bradley K Ackerson, Rulin C Hechter, Sara Y Tartof, Mendel Haag, Jeffrey M Slezak, Yi Luo, Christine A Fischetti, Harp S Takhar, Yan Miao, Marianne Cunnington, Zendi Solano, Steven J Jacobsen
BACKGROUND: Meningococcal conjugate vaccination is recommended in the United States. This study evaluates the safety of quadrivalent meningococcal conjugate vaccine in a cohort aged 11 to 21 years. METHODS: This cohort study with self-controlled case-series analysis was conducted at Kaiser Permanente Southern California. Individuals receiving MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, during September 30, 2011 to June 30, 2013, were included. Twenty-six prespecified events of interest (EOIs), including neurologic, rheumatologic, hematologic, endocrine, renal, pediatric, and pediatric infectious disease EOIs, were identified through electronic health records 1 year after vaccination...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/28024455/the-neisseria-meningitidis-lpxl1-mutant-induces-less-tissue-factor-expression-and-activity-in-primary-human-monocytes-and-monocyte-derived-microvesicles-than-the-wild-type-meningococcus
#19
Marit Hellum, Anne-Marie S Trøseid, Jens P Berg, Petter Brandtzaeg, Reidun Øvstebø, Carola E Henriksson
Neisseria meningitidis (N. meningitidis) may cause sepsis and meningitis. N. meningitidis with a mutated lpxL1 gene has five, instead of six, acyl chains in the lipid A moiety. Compared with patients infected with the wild type (wt) meningococcus, patients infected with the lpxL1 mutant have a mild meningococcal disease with less systemic inflammation and less coagulopathy. Circulating tissue factor (TF), the main initiator of coagulation, has a central role in the development of coagulation disturbances during sepsis...
January 1, 2016: Innate Immunity
https://www.readbyqxmd.com/read/28018927/meningococcal-disease-in-patients-with-human-immunodeficiency-virus-infection-a-review-of-cases-reported-through-active-surveillance-in-the-united-states-2000-2008
#20
Christine M Harris, Henry M Wu, Jianmin Li, H Irene Hall, Adria Lee, Elizabeth Zell, Lee H Harrison, Susan Petit, Monica M Farley, Ruth Lynfield, Lisa Miller, Megin Nichols, Arthur Reingold, William Schaffner, Ann Thomas, Jessica R MacNeil, Thomas A Clark, Amanda C Cohn
BACKGROUND: Although human immunodeficiency virus (HIV) infection is an established risk factor for several bacterial infections, the association between HIV infection and meningococcal disease remains unclear. METHODS: Expanded chart reviews were completed on persons with meningococcal disease and HIV infection reported from 2000 through 2008 from 9 US sites participating in an active population-based surveillance system for meningococcal disease. The incidence of meningococcal disease among patients meeting Centers for Disease Control and Prevention acquired immune deficiency syndrome (AIDS) surveillance criteria was estimated using data from the National HIV Surveillance System for the participating sites...
October 2016: Open Forum Infectious Diseases
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