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https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#1
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29036336/missed-opportunities-for-human-papillomavirus-vaccine-initiation-in-an-insured-adolescent-female-population
#2
Claudia M Espinosa, Gary S Marshall, Charles R Woods, Qianli Ma, Derek Ems, Irene Nsiah, Laura E Happe, Michael J Smith
Background: This study assessed the initiation of HPV vaccination in insured adolescent females in relation to physician visits and receipt of other vaccines routinely given at the same age. Methods: January 1, 2010, and September 31, 2015. Vaccination administration was determined by using Current Procedural Terminology codes. A missed opportunity was defined as the absence of an HPV vaccine at the following encounter types: visits with a 4-valent meningococcal conjugate vaccine (MenACWY) or tetanus, diphtheria, and acellular pertussis (Tdap) vaccine claim; well adolescent visits; or any encounter with a primary care provider (PCP)...
September 23, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29031481/systemic-lupus-erythematosus-following-meningococcal-vaccination
#3
Alexandria D Holmes, Osman Z Abbasi, Jeanne L Jacoby
No abstract text is available yet for this article.
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29026659/emergence-and-genomic-diversification-of-a-virulent-serogroup-w-st-2881-cc175-neisseria-meningitidis-clone-in-the-african-meningitis-belt
#4
Araceli Lamelas, Julia Hauser, Jean-Pierre Dangy, Abdul-Wahab M Hamid, Katharina Röltgen, Mohamad R Abdul Sater, Abraham Hodgson, Ali Sie, Thomas Junghanss, Simon R Harris, Julian Parkhill, Stephen D Bentley, Gerd Pluschke
Countries of the African 'meningitis belt' are susceptible to meningococcal meningitis outbreaks. While in the past major epidemics have been primarily caused by serogroup A meningococci, W strains are currently responsible for most of the cases. After an epidemic in Mecca in 2000, W:ST-11 strains have caused many outbreaks worldwide. An unrelated W:ST-2881 clone was described for the first time in 2002, with the first meningitis cases caused by these bacteria reported in 2003. Here we describe results of a comparative whole-genome analysis of 74 W:ST-2881 strains isolated within the framework of two longitudinal colonization and disease studies conducted in Ghana and Burkina Faso...
August 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29021440/meningococcal-bursitis
#5
Rentaro Oda, Yoshiyuki Sekikawa, Igen Hongo
No abstract text is available yet for this article.
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28992986/pros-and-cons-of-vaccination-against-disease-caused-by-serogroup-b-meningococcal-disease
#6
REVIEW
Miguel Delgado Rodríguez, Ángela Domínguez García
A vaccine has recently been approved in the EU against meningococcal serogroup B, the main cause of meningococcal disease. There is a fierce debate about the decision regarding a universal vaccination in infants older than 2 months, as recommended by the majority of scientific societies. In western Europe the only country to have included the universal vaccination is the United Kingdom, with a lower incidence of the disease than Ireland. Other countries have also adopted it, such as the Czech Republic, Cuba and certain regions of Italy...
October 7, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28992391/four-years-of-case-based-surveillance-of-meningitis-following-the-introduction-of-menafrivac-in-moissala-chad-lessons-learned
#7
Anne-Laure Page, Matthew E Coldiron, Kadidja Gamougam, Mahmaat Ali Acyl, Mbaihol Tamadji, Céline Lastrucci, Northan Hurtado, François-Charles Tehoua, Florence Fermon, Dominique A Caugant, Klaudia Porten
OBJECTIVE: Case-based surveillance of bacterial meningitis in sentinel districts has been recommended after the introduction of the conjugated vaccine against Neisseria meningitidis serogroup A (NmA), MenAfriVac, in the African meningitis belt. Here we report data and lessons learnt from four years of surveillance in the district of Moissala, Chad. METHODS: All suspected cases of meningitis were referred free of charge to the district hospital for lumbar puncture and treatment...
October 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28987549/potential-impact-of-the-4cmenb-vaccine-on-oropharyngeal-carriage-of-neisseria-meningitidis
#8
Raquel Abad, Verónica Medina, Maria Del Carmen Fariñas, Luis Martínez-Martínez, Stefania Bambini, A Dari, Duccio Medini, Mariagrazia Pizza, Julio A Vázquez
The analysis of the potential impact of the meningococcal vaccines in asymptomatic carriers has become one of the key aspects in the evaluation of new vaccines and of their impact on disease control. An important step in this direction is provided by the analysis of the sequence variability and surface-exposure of the 4CMenB (Bexsero®) vaccine antigens, as well as the cross-reactivity of vaccine induced antibodies, in isolates from healthy carriers. The Spanish Reference Laboratory, in collaboration with the University Hospital Marqués de Valdecilla in Santander (Spain), carried out a meningococcal carrier survey between May 2010 and April 2012 (population aged 4 to 19 years)...
October 5, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28974828/does-dexamethasone-helps-in-meningococcal-sepsis
#9
Ilir Tolaj, Hamdi Ramadani, Murat Mehmeti, Hatixhe Gashi, Arbana Kasumi, Visar Gashi, Haki Jashari
PURPOSE: Prompt recognition and aggressive early treatment are the only effective measures against invasive meningococcal disease (IMD). Anti-inflammatory adjunctive treatment remains controversial and difficult to assess in patients with IMD. The purpose of this study was to evaluate the effect of dexamethasone (DXM) as adjunctive treatment in different clinical forms of IMD, and attempt to answer if DXM should be routinely used in the treatment of IMD. METHODS: In this non-interventional clinical study (NIS), 39 patients with meningococcal septicaemia with or without of meningitis were included, and compared regarding the impact of dexamethasone (DXM), as an adjunctive treatment, on the outcome of IMD...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28972486/levels-of-neurospecific-markers-in-cerebrospinal-fluid-of-adult-patients-with-bacterial-meningitis
#10
A Sokhan, Y Zots, A Gavrylov, K Iurko, A Solomennik, A Kuznietsova
At present, the great attention is given to the neurospecific markers as their elevated level in the cerebrospinal fluid corresponds to the degree of destruction of relevant CNS cells. Therefore, actual direction of the studies of the pathogenesis and diagnosis of CNS diseases is to determine levels of neurospecific markers in the cerebrospinal fluid (CSF). The purpose of the study was to evaluate the diagnostic and prognostic role of NSE, S-100 protein, GFAP and MBP levels in CSF of patients with acute bacterial meningitis...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28968661/meningococcal-carriage-following-a-university-serogroup-b-meningococcal-disease-outbreak-and-vaccination-campaign-with-menb-4c-and-menb-fhbp-oregon-2015-2016
#11
Lucy A McNamara, Jennifer Dolan Thomas, Jessica MacNeil, How Yi Chang, Michael Day, Emily Fisher, Stacey Martin, Tasha Poissant, Susanna E Schmink, Evelene Steward-Clark, Laurel Thompson Jenkins, Xin Wang, Anna Acosta
Background: Limited data exist on the impact of the serogroup B meningococcal (MenB) vaccines MenB-FHbp and MenB-4C on meningococcal carriage and herd protection. We therefore assessed meningococcal carriage following a MenB vaccination campaign in response to a university serogroup B meningococcal disease outbreak in 2015. Methods: A convenience sample of students recommended for vaccination provided oropharyngeal swabs and completed questionnaires during four carriage surveys over 11 months...
August 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28968148/successful-african-introduction-of-a-new-group-a-meningococcal-conjugate-vaccine-future-challenges-and-next-steps
#12
F Marc LaForce, Mamoudou Djingarey, Simonetta Viviani, Marie-Pierre Preziosi
The introduction of a new Group A meningococcal conjugate vaccine, MenAfriVac(R), has been a important public health success. Group A meningococcal meningitis has disappeared in all countries where the new Men A conjugate vaccine has been used at public health scale. However, continued control of Group A disease in sub-Saharan Africa will require that community immunity against Group A meningococci be maintained. Modeling studies have shown that unless herd immunity is maintained Group A meningococcal disease will return...
October 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28965718/efficacy-and-immunogenicity-of-a-vi-tetanus-toxoid-conjugate-vaccine-in-the-prevention-of-typhoid-fever-using-a-controlled-human-infection-model-of-salmonella-typhi-a-randomised-controlled-phase-2b-trial
#13
Celina Jin, Malick M Gibani, Maria Moore, Helene B Juel, Elizabeth Jones, James Meiring, Victoria Harris, Jonathan Gardner, Anna Nebykova, Simon A Kerridge, Jennifer Hill, Helena Thomaides-Brears, Christoph J Blohmke, Ly-Mee Yu, Brian Angus, Andrew J Pollard
BACKGROUND: Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy but there are no efficacy data for the leading candidate vaccine being considered for widespread use. To address this knowledge gap, we assessed the efficacy of a Vi-tetanus toxoid conjugate vaccine using an established human infection model of S Typhi...
September 28, 2017: Lancet
https://www.readbyqxmd.com/read/28962886/dissemination-of-the-st-103-clonal-complex-serogroup-c-meningococci-in-salvador-brazil
#14
Soraia Machado Cordeiro, Cristiane Wanderley Cardoso, Lorena Galvão de Araújo, Luis Eduardo Ribeiro, Jailton Azevedo, Rita de Cassia Vilasboas Silva, Mitermayer Galvão Dos Reis, Albert Icksang Ko, Joice Neves Reis
Invasive meningococcal disease (IMD) is a major public health problem worldwide. An epidemic of serogroup C (NmC) IMD occurred in 2010 in the city of Salvador. In this study, we describe the antigenic and genetic characterization of meningococcal isolates collected from meningitis cases in Salvador from 2001 to 2012. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were performed for the analysis of IMD isolates. A total of 733 cases were identified, and the serogroup was determined for 391 (53...
September 27, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28957623/two-dose-menb-fhbp-trumenba-for-meningococcal-disease-prevention
#15
Brittanie A Venard, Wendy Jensen Bender
No abstract text is available yet for this article.
October 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28956803/infant-immunization-coverage-in-italy-2000-2016
#16
Carlo Signorelli, Anna Odone, Paola Cella, Stefania Iannazzo, Fortunato D'Ancona, Raniero Guerra
BACKGROUND: In Italy, national-level immunization polices are included in the National Immunization Prevention Plan (PNPV), whose latest edition - 2017-2019 PNPV - was finally approved in February 2017. Coverage rates are a key measure of immunization system performance; it can inform and support national and regional polices' implementation monitoring, as well as measure the impact of interventions aimed at increasing vaccine uptake. METHODS: We collected, analysed and critically interpreted 2000-2016 Italian national infant immunization coverage trends, by different vaccine, target population, and by Region...
July 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28953725/the-functional-angiosome-clinical-implications-of-the-anatomical-concept
#17
G Ian Taylor, Russell J Corlett, Mark W Ashton
BACKGROUND: The angiosome is a three-dimensional block of tissue supplied by a source vessel with its boundary outlined either by an anastomotic perimeter of reduced-caliber choke vessels or by true anastomoses with no reduction of vessel caliber. This article focuses on the role of these anastomotic vessels in defining flap survival or the necrotic pattern seen in fulminating meningococcal septicemia. METHODS: Experiments in pigs, dogs, guinea pigs, and rabbits over the past 46 years were reviewed, focusing on the necrosis line of flaps, the effects of various toxins in vivo, and correlating these results in the clinical setting...
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28947346/using-the-4-pillars%C3%A2-practice-transformation-program-to-increase-adolescent-human-papillomavirus-meningococcal-tetanus-diphtheria-pertussis-and-influenza-vaccination
#18
Richard K Zimmerman, Jonathan M Raviotta, Mary Patricia Nowalk, Krissy K Moehling, Evelyn Cohen Reis, Sharon G Humiston, Chyongchiou Jeng Lin
OBJECTIVES: To report the results of an intervention using the 4 Pillars™ Practice Transformation Program (4 Pillars™ Program) to increase adolescent vaccinations including human papillomavirus vaccine (HPV) and influenza vaccines, which remain underutilized in this population. STUDY DESIGN: Eleven pediatric and family medicine practices, previously control sites from a randomized controlled cluster trial, with ≥50 adolescent patients participated. The 4 Pillars™ Program was the foundation of the intervention...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28941623/post-licensure-safety-surveillance-study-of-routine-use-of-quadrivalent-meningococcal-diphtheria-toxoid-conjugate-vaccine
#19
J Hansen, L Zhang, N P Klein, C A Robertson, M D Decker, D P Greenberg, E Bassily, R Baxter
BACKGROUND: Menactra® vaccine (MenACWY-D) was licensed in the United States in 2005 for persons 11-55years of age. The aim of this study was to assess the safety of MenACWY-D administered as part of routine clinical care to patients at Kaiser Permanente Northern California (KPNC). METHODS: This was an observational, retrospective study that included all KPNC members who received MenACWY-D during the study period. We monitored all vaccine recipients for non-elective hospitalizations, emergency department visits, and selected outcomes captured in the clinic setting (Bell's palsy, seizures, neuritis, Guillain-Barré syndrome, encephalopathy, encephalitis, epilepsy, transverse myelitis, multiple sclerosis, hypersensitivity reactions, idiopathic thrombocytopenic purpura, diabetes, arthritis, hemolytic anemia, collagen-vascular disease) through 6months after vaccination...
September 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28935471/prevalence-and-decay-of-maternal-pneumococcal-and-meningococcal-antibodies-a-meta-analysis-of-type-specific-decay-rates
#20
Merryn Voysey, Andrew J Pollard, Manish Sadarangani, Thomas R Fanshawe
BACKGROUND: At the time of an infant's initial vaccination at age ∼2 to 3months, some infants already have maternal antibodies against vaccine antigens and these can suppress the immune response to vaccination. Modelling the effects of maternal antibody and the timing of infant doses on the antibody response to vaccination, requires estimates of the rate of maternal antibody decay. Decay rates are not well characterised in the medical literature. We investigated variation in the prevalence of maternal anti-capsular pneumococcal and meningococcal antibodies in infants in 14 countries, and estimated type-specific half-lives...
October 13, 2017: Vaccine
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