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Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occurring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least one sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
November 2016: Pediatric Infectious Disease Journal
Julie A Bettinger, Otto G Vanderkooi, David W Scheifele, Scott A Halperin, James D Kellner, Anthony Schryvers, Gaston De Serres, Joenel Alcantara
BACKGROUND: The diversity of Canadian infant meningococcal C conjugate (MenC) vaccine programs is unique among countries providing MenC vaccines and offers a valuable opportunity to determine the optimal vaccine program. This longitudinal study assessed differences in seroprotection by 3 different vaccine schedules in children two years after receiving either 1 toddler MenC vaccine dose (1 dose), 1 infant and 1 toddler dose (2 doses), or 2 infant and 1 toddler MenC vaccine dose (3 doses)...
November 2016: Pediatric Infectious Disease Journal
Francesca Angelotti, Antonio Tavoni
September 7, 2016: Clinical and Experimental Rheumatology
Helen S Marshall, Peter C Richmond, Johannes Beeslaar, Qin Jiang, Kathrin U Jansen, Maria Garcés-Sánchez, Federico Martinón-Torres, Leszek Szenborn, Jacek Wysocki, Joseph Eiden, Shannon L Harris, Thomas R Jones, Su-San Lee, John L Perez
BACKGROUND: Bivalent rLP2086 is a recombinant factor H binding protein-based vaccine approved in the USA for prevention of meningococcal serogroup B disease in 10-25-year-olds. We aimed to assess the persistence of bactericidal antibodies up to 4 years after a three-dose schedule of bivalent rLP2086. METHODS: We did this randomised, single-blind, placebo-controlled, phase 2 trial at 25 sites in Australia, Poland, and Spain. In stage 1 of the study (February, 2009-May, 2010), healthy adolescents (aged 11-18 years) were randomly assigned, via an interactive voice and web-response system with computer-generated sequential random numbers, to receive either ascending doses of vaccine (60 μg, 120 μg, and 200 μg) or placebo at months 0, 2, and 6...
October 10, 2016: Lancet Infectious Diseases
David S Stephens
No abstract text is available yet for this article.
October 10, 2016: Lancet Infectious Diseases
Krzysztof Korzeniewski, M Konior, M Kiedrowska, E Wódka, E Zwolińska, A Skoczyńska
The article presents the prevalence of Neisseria meningitidis carriage with the identification of sero- and genogroups in professional soldiers serving in the Polish Armed Forces. A total of 1246 soldiers from the 10th Armored Cavalry Brigade in Świętoszów, Poland were examined in the period January-February 2016. Microbiological tests were performed using standard methods (culture, incubation, microscopy, biochemical, and automated identification with VITEK cards). Neisseria meningitidis isolates from carriers were subjected to a slide agglutination test for the identification of serogroups, next bacterial DNA was isolated and genogroups were identified based on the results of PCR...
October 14, 2016: Advances in Experimental Medicine and Biology
Jacek Wysocki, Jerzy Brzostek, Ryszard Konior, Falko G Panzer, Nancy A François, Sudheer M Ravula, Devayani A Kolhe, Yue Song, Ilse Dieussaert, Lode Schuerman, Dorota Borys
To investigate long-term antibody persistence following the administration of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV), we present results of two follow-up studies assessing antibody persistence following two 3+1 schedules up to four (NCT00624819 - Study A) and five years (NCT00891176 - Study B) post-booster vaccination. In Study A, antibody persistence was measured one, two and four years post-booster in children previously primed and boosted with PHiD-CV, or primed with the 7-valent pneumococcal conjugate vaccine (7vCRM) and boosted with either PHiD-CV or 7vCRM...
October 13, 2016: Human Vaccines & Immunotherapeutics
Ala-Eddine Deghmane, Eva Hong, Muhamed-Kheir Taha
OBJECTIVES: Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012. METHODS: Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested...
October 12, 2016: Journal of Antimicrobial Chemotherapy
Srivani Nm, Dilip M Rampure, G Rajashekharappa
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Aleš Chrdle, Vaclav Chmelik, Daniel Ruzek
Tick-borne encephalitis (TBE) is an acute febrile illness with neurological manifestations that is prevalent in forested areas of moderate climate in Europe and Asia. TBE virus is transmitted by ticks and rarely by unpasteurized milk and dairy products. The disease burden is attributed mainly to resulting long-term disability, especially in individuals over 50 years of age. Currently, there is no causative treatment, but a very effective vaccination is available with a good safety profile. The vaccination requires three basic doses to be fully effective and regular boosters afterwards...
August 15, 2016: Human Vaccines & Immunotherapeutics
Jesús Arenas, Jan Tommassen
Extracellular DNA (eDNA) is an essential constituent of the extracellular matrix of biofilms of many microorganisms. In spite of many studies, it has long remained unclear how exactly eDNA exerts its role in biofilm formation. Here, we describe recent advances that have been made in understanding biofilm formation in the human pathogen Neisseria meningitidis. Several cell-surface-exposed proteins have been identified that bind DNA and other negatively charged polymers, such as heparin, by electrostatic interactions...
October 3, 2016: Trends in Microbiology
Amy E Blain, Sema Mandal, Henry Wu, Jessica R MacNeil, Lee H Harrison, Monica M Farley, Ruth Lynfield, Lisa Miller, Megin Nichols, Sue Petit, Arthur Reingold, William Schaffner, Ann Thomas, Shelley M Zansky, Raydel Anderson, Brian H Harcourt, Leonard W Mayer, Thomas A Clark, Amanda C Cohn
In 2009, in the Active Bacterial Core surveillance sites, penicillin was not commonly used to treat meningococcal disease. This is likely because of inconsistent availability of antimicrobial susceptibility testing and ease of use of third-generation cephalosporins. Consideration of current practices may inform future meningococcal disease management guidelines.
September 2016: Open Forum Infectious Diseases
Monique T Barakat, Kiran Gajurel, Katrina Fischer, Kathryn Stevens, Errol Ozdalga, José G Montoya
The clinical spectrum of Neisseria meningitidis can range from nasopharyngeal colonization to life-threatening invasive diseases such as meningitis. However, its etiologic role in invasive pyomyositis (PM) has never been reported before in the English language. In this study, we report the first case of PM in the English language and the second case in the literature caused by N meningitidis.
September 2016: Open Forum Infectious Diseases
Imran Khan, K M Taufiqur Rahman, S M Saad Us Siraj, Mahbubul Karim, Abdul Muktadir, Arpan Maheshwari, Md Azizul Kabir, Zebun Nahar, Mohammad Mainul Ahasan
Molecular size distribution of meningococcal polysaccharide vaccine is a readily identifiable parameter that directly correlates with the immunogenicity. In this paper, we report a size exclusion chromatography method to determine the molecular size distribution and distribution coefficient value of meningococcal polysaccharide serogroups A, C, W, and Y in meningococcal polysaccharide (ACWY) vaccines. The analyses were performed on a XK16/70 column packed with sepharose CL-4B with six different batches of Ingovax® ACWY, a meningococcal polysaccharide vaccine produced by Incepta Vaccine Ltd...
2016: International Journal of Analytical Chemistry
Sabrina B Roberts, Russell Spencer-Smith, Mahwish Shah, Jean-Christophe Nebel, Richard T Cook, Lori A S Snyder
Neisseria gonorrhoeae is capable of causing gonorrhoea and more complex diseases in the human host. Neisseria meningitidis is a closely related pathogen that shares many of the same genomic features and virulence factors, but causes the life threatening diseases meningococcal meningitis and septicaemia. The importance of non-coding RNAs in gene regulation has become increasingly evident having been demonstrated to be involved in regulons responsible for iron acquisition, antigenic variation, and virulence. Neisseria spp...
August 25, 2016: Microorganisms
Martin Lappann, Andreas Otto, Madita Brauer, Dörte Becher, Ulrich Vogel, Kay Johswich
Neisseria meningitidis, the meningococcus, bears the potential of life-threatening invasive diseases, but it usually colonizes the nasopharynx without causing any symptoms. Within the nasopharynx, Neisseria meningitidis must face temperature changes depending on the ambient air temperature. Indeed, the nasopharyngeal temperature can be substantially lower than 37°C, the temperature commonly used in experimental settings. Here, we compared meningococcal biofilm formation, autoaggregation and cellular adherence between 32°C and 37°C and found a clear increase in all these phenotypes at 32°C, suggestive for a stronger in vivo colonization capability at this temperature...
September 26, 2016: Infection and Immunity
Preeti Pathela, Kelly Jamison, Vikki Papadouka, Rezaul Kabir, Lauri E Markowitz, Eileen F Dunne, Julia A Schillinger
PURPOSE: Human papillomavirus (HPV) vaccine is recommended for adolescents. By the end of 2013, 64% of female and 40% of male New York City residents aged 13-18 years had received ≥1 HPV vaccine dose. Adolescents attending sexually transmitted disease (STD) clinics are at high risk for HPV exposure and could benefit from vaccination. Our objective was to estimate HPV vaccination coverage for this population. METHODS: We matched records of New York City's STD clinic patients aged 13-18 years during 2010-2013 with the Citywide Immunization Registry...
September 23, 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Theano Georgakopoulou, Damianos Menegas, Antonis Katsioulis, Maria Theodoridou, Jenny Kremastinou, Christos Hadjichristodoulou
Vaccination coverage studies are important in determining a population vaccination status and strategically adjusting national immunization programs. This study assessed full and timely vaccination coverage of preschool children aged 2-3 years attending nurseries-kindergartens (N-K) nationwide at the socioeconomic crisis onset. Geographically stratified cluster sampling was implemented considering prefectures as strata and N-K as clusters. The N-K were selected by simple random sampling from the sampling frame while their number was proportional to the stratum size...
September 26, 2016: Human Vaccines & Immunotherapeutics
Ilaria Izzo, Paola Pileri, Maria Merello, Paolo Gnesin, Enrico Cogi, Carlo Aggiusti, Laura Giacomelli, Stefano Ettori, Paolo Colombini, Andrea Collidá
A young woman was examined in the Emergency Department for fever, pharyngitis and widespread petechial rash. Physical examination, including neurological evaluation, did not show any other abnormalities. Chest X-ray was negative. Blood exams showed leukocytosis and CPR 20 mg/dL (nv<0.5 mg/dL). On the basis of these results and petechial rash evidence, lumbar puncture was performed. CSF was opalescent; physico-chemical examination showed: total proteins 2.8 (nv 0.15-0.45), glucose 5 (nv 59-80), WBC 7600/μL (nv 0-4/ μL)...
September 1, 2016: Le Infezioni in Medicina
Dan M Granoff, Serena Giuntini, Flor A Gowans, Eduardo Lujan, Kelsey Sharkey, Peter T Beernink
Meningococcal factor H-binding protein (FHbp) is an antigen in 2 serogroup B meningococcal vaccines. FHbp specifically binds human and some nonhuman primate complement FH. To investigate the effect of binding of FH to FHbp on protective antibody responses, we immunized infant rhesus macaques with either a control recombinant FHbp antigen that bound macaque FH or a mutant antigen with 2 amino acid substitutions and >250-fold lower affinity for FH. The mutant antigen elicited 3-fold higher serum IgG anti-FHbp titers and up to 15-fold higher serum bactericidal titers than the control FHbp vaccine...
2016: JCI Insight
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