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Traditional Chinese Medicine

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https://www.readbyqxmd.com/read/27935251/simultaneous-determination-of-35-ultra-trace-level-organophosphorus-pesticide-residues-in-sanjie-zhentong-capsules-of-traditional-chinese-medicine-using-ultra-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#1
Jiachun Li, Dongpo Li, Jingling Wu, Jianping Qin, Junhua Hu, Wenzhe Huang, Zhenzhong Wang, Wei Xiao, Yu Wang
The aim of this study was to develop an analytical method for the simultaneous determination of ultra-trace levels of 35 organophosphorus pesticide residues in Sanjie Zhentong capsules, a traditional Chinese medicine prescription. A method based on multiclass and multiresidue sample preparation was developed. First, samples were hydrated with water in 4°C. A ratio of 1:3 sample/water was used for each of the sample amounts. Then, different extraction solvents were screened. This step was followed by a dispersive solid-phase extraction clean-up procedure using both primary secondary amine and polyamide...
December 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27935213/uhplc-q-tof-ms-based-metabolomics-approach-to-compare-the-saponin-compositions-of-xueshuantong-injection-and-xuesaitong-injection
#2
Changliang Yao, Wenzhi Yang, Jingxian Zhang, Shi Qiu, Ming Chen, Xiaojian Shi, Huiqin Pan, Wanying Wu, Dean Guo
Various traditional Chinese medicine preparations developed from Notoginseng total saponins, including Xueshuantong Injection and Xuesaitong Injection, are extensively used in China to treat cardio-cerebrovascular diseases. However, the difference of their saponin compositions remains unknown. An ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry based metabolomics approach was developed to probe the saponin discrimination between Xueshuantong and Xuesaitong and the related factors by large sample analysis...
December 9, 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27933584/matrine-treatment-blocks-nogoa-induced-neural-inhibitory-signaling-pathway-in-ongoing-experimental-autoimmune-encephalomyelitis
#3
Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Li Zhu
Myelin-associated inhibitors, such as NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp), play a pivotal role in the lack of neuroregeneration in multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (CNS). Matrine (MAT), a monomer that is used in traditional Chinese medicine as an anti-inflammatory agent, has shown beneficial effects in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. However, the underlying mechanisms of MAT-induced EAE amelioration are not fully understood...
December 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27932881/preparation-and-antitumor-evaluation-of-self-assembling-oleanolic-acid-loaded-pluronic-p105-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-mixed-micelles-for-non-small-cell-lung-cancer-treatment
#4
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932514/long-term-therapy-with-wu-ling-san-a-popular-antilithic-chinese-herbal-formula-did-not-prevent-subsequent-stone-surgery-a-nationwide-population-based-cohort-study
#5
San-Yuan Wu, Huey-Yi Chen, Kao-Sung Tsai, Jen-Huai Chiang, Chih-Hsin Muo, Fung-Chang Sung, Yung-Hsiang Chen, Wen-Chi Chen
Traditional Chinese herbal medicine (CHM), which is widely used to treat pain and urolithiasis, is a promising therapy for urinary stone prevention. This study investigated the clinical efficacy of a popular CHM, Wu-Ling-San (WLS), in Taiwan for the prophylaxis of recurrent nephrolithiasis as assessed by surgical stone treatment via a nationwide population-based cohort study. The National Health Insurance Research Database, 2000-2010, which included one million patient records. All patients diagnosed with stone disease at the beginning of the study...
2016: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/27931287/ttf1-nps-induce-ers-mediated-apoptosis-and-inhibit-human-hepatoma-cell-growth-in-vitro-and-in-vivo
#6
Bin Xiao, Chao Liu, Bing-Tong Liu, Xuan Zhang, Rong-Rong Liu, Xue-Wu Zhang
Previous studies have shown that 5,2,4-trihydroxy-6,7,5-trimethoxyflavone (TTF1) is the primary anticancer constituent of the traditional Chinese medicinal plant Sorbaria sorbifolia (SS), which has been applied to treat cancer in China. In this study, we investigated the in vitro and in vivo antitumor effects and biological mechanisms of small-molecule TTF1 nanoparticles (TTF1-NPs). The effects of TTF1-NPs on cell growth and apoptosis were investigated using human hepatoma cells. The molecular changes associated with the effects of TTF1-NPs were analyzed by immunocytochemistry and Western blot analysis...
May 2016: Oncology Research
https://www.readbyqxmd.com/read/27931128/antioxidant-activities-of-ginsenoside-rg1-against-cisplatin-induced-hepatic-injury-through-nrf2-signaling-pathway-in-mice
#7
Yan Gao, Shifeng Chu, Qianhang Shao, Meijin Zhang, Congyuan Xia, Yingying Wang, Yueting Li, Yuxia Lou, Huiyong Huang, Naihong Chen
Oxidative stress is mainly caused by reactive oxygen species (ROS). The damage causes a net stress on normal organs, leading to a gradual loss of vital physiological function. ROS, such as free radicals, represent a class of molecules which are derived from the metabolism of oxygen and exist inherently. However, excessive produced ROS can damage all aerobic organisms. Ginseng is one of the most commonly used alternative herbal medicines, also as a traditional Chinese medicine. The aim of this study is to investigate the antioxidant potential function of ginsenoside Rg1 against cisplatin-caused hepatic damage...
December 8, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27930981/inhibiting-pi3k-akt-signaling-pathway-is-involved-in-antitumor-effects-of-ginsenoside-rg3-in-lung-cancer-cell
#8
Qipeng Xie, Huaikai Wen, Qiong Zhang, Weihe Zhou, Xiaoming Lin, Deyao Xie, Yu Liu
Lung cancer is recognized as the most prevalent type of cancer with high death rate. Ginsenoside Rg3 isolated from Traditional Chinese Medicine Panax Ginseng has significant anticancer effects on many tumors. In this study, the effects of ginsenoside Rg3 on cells viability, apoptosis and PI3K/Akt signaling pathway in lung cancer cells were investigated in vitro and in vivo. In vitro, the viability of lung cancer cell lines A549,H23 was examined by CCK-8 kits; The proportion of cell apoptosis was measured by flow cytometry...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930972/the-anti-hyperplasia-of-mammary-gland-effect-of-protein-extract-hss-from-tegillarca-granosa
#9
Yuping Jia, Xiu Liu, Qingwen Jia, Wei Zhang, Chao Sun, Dongdong Yuan, Haoran Zhang, Ena Jiang, Dongshun Zhou
Tegillarca granosa Linnaeus, possesses various biological functions and has been used a Chinese traditional medicine more than one century, but there is no report about anti-hyperplasia of mammary gland (HMG) activity of drugs from T. granosa. In this study, we investigated the anti-HMG effect of protein extract named HSS from T. granosa. The HMG model of virgin female Sprague Dawley rats was prepared by injecting estrogen in the thigh muscle of the rats and progestogen consecutively. HMG rats were treated with either HSS or positive control drug by i...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930947/ginseng-and-obesity-observations-and-understanding-in-cultured-cells-animals-and-humans
#10
REVIEW
Longyun Zhang, Carlos Virgous, Hongwei Si
Ginseng, a traditional medical herb, has been reported having beneficial effects in fatigue, heart diseases, diabetes, immune function and erectile dysfunction. In recent years, increasing investigations have been conducted on ginseng in preventing and treating of obesity, one of the major worldwide escalating public health concerns. However, the effect and the relevant mechanisms behind how ginseng works as an antiobesity treatment are still controversial. In this review, we briefly discussed the chemical structures, metabolism and pharmacokinetics of ginseng and its major bioactive components ginsenosides...
November 23, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27930547/modern-researches-on-blood-stasis-syndrome-1989-2015-a-bibliometric-analysis
#11
Jiangquan Liao, Jie Wang, Yongmei Liu, Jun Li, Lian Duan, Guang Chen, Junyuan Hu
BACKGROUND: Blood Stasis syndrome (BSS) is one of the major syndromes in Traditional East Asia medicine (TEAM). Modern research of BSS began in the late1980s. METHODS: We searched in PubMed for BSS-related articles published between 1989 and 2015. The publication information, study contents, and bibliometric indicators were documented and analyzed. RESULTS: Most of the BSS-related studies were conducted by Chinese researchers in China. The number of publications on BSS-related increased rapidly in recent years, so did the quality of them...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930519/who-are-the-users-of-a-traditional-chinese-sanfu-acupoint-herbal-patching-therapy-in-china-a-cross-sectional-survey
#12
Fen Zhou, Hong-Jun Wu, Jun-Ping Zhai, Gui-Yan Zhang, Yan Shao, Xia Tian, Ru-Yu Xia, Li-Yan Jia, Wen-Yuan Li, Ning Liang, Xiao-Yi Yan, Ruo-Han Wu, Kang Zhang, Xin-Lin Li, Cong-Cong Wang, Jian-Ping Liu
Sanfu acupoint herbal patching (SAHP) is a unique traditional Chinese medicine therapy, which has become popular for preventing acute attack of respiratory diseases such as asthma and chronic obstructive pulmonary disease, in many regions of mainland China. However, the knowledge about its users is lacking, especially the characteristics of the users and their experience and perspectives.To investigate the demographics of users, conditions for its use and the previous experience of SAHP, as well as users' perspectives to provide baseline information for its practice...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929437/the-traditional-chinese-medicine-dangguibuxue-tang-sensitizes-colorectal-cancer-cells-to-chemoradiotherapy
#13
Shun-Ting Chen, Tzung-Yan Lee, Tung-Hu Tsai, Yin-Cheng Lin, Chin-Ping Lin, Hui-Ru Shieh, Ming-Ling Hsu, Chih-Wen Chi, Ming-Cheng Lee, Hen-Hong Chang, Yu-Jen Chen
Chemotherapy is an important treatment modality for colon cancer, and concurrent chemoradiation therapy (CCRT) is the preferred treatment route for patients with stage II and III rectal cancer. We examined whether DangguiBuxue Tang (DBT), a traditional Chinese herbal extract, sensitizes colorectal cancer cells to anticancer treatments. The polysaccharide-depleted fraction of DBT (DBT-PD) contains greater amounts of astragaloside IV (312.626 µg/g) and ferulic acid (1.404 µg/g) than does the original formula...
December 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27927244/wuzi-yanzong-pill-a-chinese-polyherbal-formula-alleviates-testicular-damage-in-mice-induced-by-ionizing-radiation
#14
Hai-Jie Ji, Dong-Mei Wang, Yu-Peng Wu, Yan-Yan Niu, Li-Li Jia, Bi-Wang Liu, Qian-Jin Feng, Ma-Li Feng
BACKGROUND: Chinese medicine Wuzi Yanzong pill (WZYZP) was firstly documented in ancient Chinese medical works "She Sheng Zhong Miao Fang" by Shi-Che Zhang in 1550 AD. The traditional herbal formula is widely used in treating nephrasthenia lumbago, prospermia, erectile dysfunction and male sterility. The present study was to explore the effects of WZYZP on ionizing irradiation-induced testicular damage in mice. METHODS: The pelvic region of male mice was exposed to X-rays for inducing testicular damage...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27927214/antiplatelet-and-antithrombotic-effects-of-cordycepin-enriched-wib-801ce-from-cordyceps-militaris-ex-vivo-in-vivo-and-in-vitro
#15
Hyuk-Woo Kwon, Jung-Hae Shin, Deok Hwi Lim, Woo Jeong Ok, Gi Suk Nam, Min Ji Kim, Ho-Kyun Kwon, Jun-Hee Noh, Je-Young Lee, Hyun-Hong Kim, Jong-Lae Kim, Hwa-Jin Park
BACKGROUND: A species of the fungal genus Cordyceps has been used as a complementary and alternative medicine of traditional Chinese medicine, and its major component cordycepin and cordycepin-enriched WIB-801CE are known to have antiplatelet effects in vitro. However, it is unknown whether they have also endogenous antiplatelet and antithrombotic effects. In this study, to resolve these doubts, we prepared cordycepin-enriched WIB-801CE, an ethanol extract from Cordyceps militaris-hypha, then evaluated its ex vivo, in vivo, and in vitro antiplatelet and antithrombotic effects...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27927064/clinical-efficacy-of-yingliu-mixture-combined-with-metimazole-for-treating-diffuse-goitre-with-hyperthyroidism-and-its-impact-on-related-cytokines
#16
Hua Yang, Yilei Cong, Tengfei Wu, Hong Tang, Muhao Ma, Juanhua Zeng, Wenya Zhang, Zhen Lian, Xinyu Yang
CONTEXT: Yingliu mixture was developed in 1990s by Affiliated Longhua Hospital of Shanghai University of Traditional Chinese Medicine, for treating diffuse goitre with hyperthyroidism (Graves' disease, GD). Former studies have shown Yingliu mixture combined with methimazole (Y-M) can effectively improve thyroid function and decrease thyrotropin-receptor antibody level. Furthermore, we researched its impact on related cytokines to prove that Y-M improve patients' immunity status. OBJECTIVE: To observe the clinical efficacy of Y-M for treating GD...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925244/the-absorption-enhancement-of-norisoboldine-in-the-duodenum-of-adjuvant-induced-arthritis-rats-involves-the-impairment-of-p-glycoprotein
#17
Cong Duan, Jiao-Mei Guo, Yue Dai, Yu-Feng Xia
Lindera aggregate (Sims) Kosterm root has been used in traditional Chinese medicine for the treatment of rheumatism palsy, dyspepsia and frequent urination for a long history. Norisoboldine (NOR), the main active constituent of this herb drug, possesses outstanding anti-arthritis activity. However, in vivo disposition of NOR has been known to a limited extent, especially under the pathological condition of rheumatoid arthritis (RA). The aim of this study is to investigate whether and how the absorption of NOR is altered in adjuvant-induced arthritis (AIA) rats...
December 7, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27924825/an-integrated-strategy-for-global-qualitative-and-quantitative-profiling-of-traditional-chinese-medicine-formulas-baoyuan-decoction-as-a-case
#18
Xiaoli Ma, Xiaoyu Guo, Yuelin Song, Lirui Qiao, Wenguang Wang, Mingbo Zhao, Pengfei Tu, Yong Jiang
Clarification of the chemical composition of traditional Chinese medicine formulas (TCMFs) is a challenge due to the variety of structures and the complexity of plant matrices. Herein, an integrated strategy was developed by hyphenating ultra-performance liquid chromatography (UPLC), quadrupole time-of-flight (Q-TOF), hybrid triple quadrupole-linear ion trap mass spectrometry (Qtrap-MS), and the novel post-acquisition data processing software UNIFI to achieve automatic, rapid, accurate, and comprehensive qualitative and quantitative analysis of the chemical components in TCMFs...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924510/global-protein-expression-analysis-of-molecular-markers-of-ds-1-47-a-component-of-implantation-promoting-traditional-chinese-medicine
#19
Yan-Ling Li, Xiao-Yan Zhang, Yu Leng, Yan-Li Wu, Jing Li, Yun-Xia Wu
This study investigated the molecular markers of DS-1-47, a component of an implantation- promoting traditional Chinese medicine consisting of Astragalus mongholicus, Atractylodes macrocephala, Scutellaria baicalensis and Dipsacales, in an attempt to clarify the molecular mechanism and action targets of DS-1-47. Controlled ovarian stimulation (COS) method was used to establish the implantation dysfunction models of mice. Animals were divided into normal pregnant group, COS model group and DS-1-47 group. Laser capture microdissection-double dimensional electrophoresis-mass spectrum (LCM-DE-MS) was used to analyze the uterine protein molecules that were possibly involved in the promotion of implantation...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27923369/protocol-of-a-prospective-study-for-the-combination-treatment-of-shu-gan-jian-pi-decoction-and-steroid-standard-therapy-in-autoimmune-hepatitis-patients
#20
Xiao-Ling Chi, Huan-Ming Xiao, Yu-Bao Xie, Gao-Shu Cai, Jun-Min Jiang, Guang-Jun Tian, Mei-Jie Shi, Shu-Duo Wu, Peng-Tao Zhao, Hui-Jun Chen
BACKGROUND: Prednisone plus azathioprine is considered the mainstay of therapy in the current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits for AIH patients because of its serious side effects. Therefore, more and more AIH patients prefer to seek for traditional Chinese medicine (TCM) to manage their symptoms and reduce the side effects of steroids in China. Shu-Gan-Jian-Pi Decoction is a popular used Chinese herbal formula in Guangdong province of China, which has demonstrated the effect of improving efficacy and reducing side effects of corticosteroids in AIH patients...
December 7, 2016: BMC Complementary and Alternative Medicine
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