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Ganoderma lucidum review

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https://www.readbyqxmd.com/read/29081024/ganoderic-acid-lanostanoid-triterpene-a-key-player-in-apoptosis
#1
REVIEW
Balraj Singh Gill, Navgeet, Richa Mehra, Vicky Kumar, Sanjeev Kumar
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis. Apoptosis is a complex, programmed, and highly regulated process causing dramatic morphological and biochemical perturbations in the cellular machinery. Ganoderma lucidum is a basidiomycetes, polypore mushroom known for its pharmacological properties in cancer...
October 28, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29078264/overview-of-ganoderma-sinense-polysaccharide-an-adjunctive-drug-used-during-concurrent-chemo-radiation-therapy-for-cancer-treatment-in-china
#2
REVIEW
Yifei Jiang, Yajing Chang, Yong Liu, Meng Zhang, Heng Luo, Cui Hao, Pengjiao Zeng, Yue Sun, Hua Wang, Lijuan Zhang
Ganoderma sinense or "Chinese Lingzhi" is a well-known medicinal fungus in China for more than 2000 years. Polysaccharide is the main immunomodulatory and antitumor component in G. sinense. In 2010, G. sinense polysaccharide (GSP) tablet is approved as an adjunctive therapeutic drug in China for treating leukopenia and hematopoietic injury caused by concurrent chemo/radiation therapy during cancer treatment by the State Food and Drug Administration (SFDA). β-glucan, an established immunostimulant, is one of the components in GSP...
October 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28653896/ganoderma-lucidum-targeting-lung-cancer-signaling-a-review
#3
REVIEW
Balraj Singh Gill, Navgeet, Sanjeev Kumar
Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and therefore, natural products are used as a therapeutic candidate in lung cancer. Chemical diversity among natural products highlights the impact of evolution and survival of fittest. One such neglected natural product is Ganoderma lucidum used for promoting health and longevity for a longer time...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28383512/screening-and-analysis-of-the-marker-components-in-ganoderma-lucidum-by-hplc-and-hplc-ms-n-with-the-aid-of-chemometrics
#4
Lingfang Wu, Wenyi Liang, Wenjing Chen, Shi Li, Yaping Cui, Qi Qi, Lanzhen Zhang
Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. The present study was to establish a fingerprint evaluation system based on Similarity Analysis (SA), Cluster Analysis (CA) and Principal Component Analysis (PCA) for the identification and quality control of G. lucidum. Fifteen samples from the Chinese provinces of Hainan, Neimeng, Shangdong, Jilin, Anhui, Henan, Yunnan, Guangxi and Fujian were analyzed by HPLC-PAD and HPLC-MS(n)...
April 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27910768/pharmacological-properties-of-biocompounds-from-spores-of-the-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes-a-review
#5
REVIEW
Carlos Ricardo Soccol, Lucas Yamasaki Bissoqui, Cristine Rodrigues, Rosalia Rubel, Sandra R B R Sella, Fan Leifa, Luciana Porto de Souza Vandenberghe, Vanete Thomaz Soccol
Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27045603/ganoderma-lucidum-reishi-mushroom-for-cancer-treatment
#6
REVIEW
Xingzhong Jin, Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan
BACKGROUND: Ganoderma lucidum is a natural medicine that is widely used and recommended by Asian physicians and naturopaths for its supporting effects on immune system. Laboratory research and a handful of preclinical trials have suggested that G. lucidum carries promising anticancer and immunomodulatory properties. The popularity of taking G. lucidum as an alternative medicine has been increasing in cancer patients. However, there is no systematic review that has been conducted to evaluate the actual benefits of G...
April 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26868374/resolution-of-cutaneous-sarcoidosis-following-topical-application-of-ganoderma-lucidum-reishi-mushroom
#7
Gulcan Saylam Kurtipek, Arzu Ataseven, Ercan Kurtipek, İlknur Kucukosmanoglu, Mustafa Rasid Toksoz
Ganoderma lucidum (reishi mushroom) has been used in traditional Chinese and Japanese medicine as a herbal remedy for over 2000 years. Studies have shown that G. lucidum has anti-allergic, anti-oxidant, anti-tumor, anti-viral, and anti-inflammatory properties. A review of the literature revealed that there were no studies examining the use of G. lucidum for the treatment of skin diseases. Here, we report the case of a 44-year-old male patient who used soap enriched with G. lucidum and goat's milk for 3 days in treating annular cutaneous sarcoidosis...
March 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/26715282/misconstrued-versatility-of-ganoderma-lucidum-a-key-player-in-multi-targeted-cellular-signaling
#8
REVIEW
Balraj Singh Gill, Prateek Sharma, Raj Kumar, Sanjeev Kumar
A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential...
March 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26088353/tetracyclic-triterpenoids-in-herbal-medicines-and-their-activities-in-diabetes-and-its-complications
#9
Kaiser Hamid, Ali Alqahtani, Moon-Sun Kim, Jun-Lae Cho, Pei H Cui, Chun Guang Li, Paul W Groundwater, George Q Li
Tetracyclic triterpenoids, including the dammarane, cucurbitane, cycloartane, lanostane and protostane groups, is a class of triterpenoids widely distributed in various medicinal plants, particularly those commonly used for the treatment of diabetes and its complications, such as Panax ginseng, Panax quinquefolium, Panax notoginseng, Gynostemma pentaphyllum, Astragalus membranaceus, Momordica charantia, and Ganoderma lucidum. This review highlights recent findings on the chemistry and bioactivities of tetracyclic triterpenoids from these plants and other popular herbal medicines...
2015: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25975187/secondary-metabolites-from-ganoderma
#10
Sabulal Baby, Anil John Johnson, Balaji Govindan
Ganoderma is a genus of medicinal mushrooms. This review deals with secondary metabolites isolated from Ganoderma and their biological significance. Phytochemical studies over the last 40years led to the isolation of 431 secondary metabolites from various Ganoderma species. The major secondary compounds isolated are (a) C30 lanostanes (ganoderic acids), (b) C30 lanostanes (aldehydes, alcohols, esters, glycosides, lactones, ketones), (c) C27 lanostanes (lucidenic acids), (d) C27 lanostanes (alcohols, lactones, esters), (e) C24, C25 lanostanes (f) C30 pentacyclic triterpenes, (g) meroterpenoids, (h) farnesyl hydroquinones (meroterpenoids), (i) C15 sesquiterpenoids, (j) steroids, (k) alkaloids, (l) prenyl hydroquinone (m) benzofurans, (n) benzopyran-4-one derivatives and (o) benzenoid derivatives...
June 2015: Phytochemistry
https://www.readbyqxmd.com/read/25865774/tissue-invasion-and-metastasis-molecular-biological-and-clinical-perspectives
#11
REVIEW
W G Jiang, A J Sanders, M Katoh, H Ungefroren, F Gieseler, M Prince, S K Thompson, M Zollo, D Spano, P Dhawan, D Sliva, P R Subbarayan, M Sarkar, K Honoki, H Fujii, A G Georgakilas, A Amedei, E Niccolai, A Amin, S S Ashraf, L Ye, W G Helferich, X Yang, C S Boosani, G Guha, M R Ciriolo, K Aquilano, S Chen, A S Azmi, W N Keith, A Bilsland, D Bhakta, D Halicka, S Nowsheen, F Pantano, D Santini
Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast percentage of cancer patient mortality. While advances in this area have been made, the process of cancer metastasis and the factors governing cancer spread and establishment at secondary locations is still poorly understood. The current article summarizes recent progress in this area of research, both in the understanding of the underlying biological processes and in the therapeutic strategies for the management of metastasis...
December 2015: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/25811312/the-impact-of-complementary-and-alternative-medicines-on-cancer-symptoms-treatment-side-effects-quality-of-life-and-survival-in-women-with-breast-cancer-a-systematic-review
#12
REVIEW
S Leggett, B Koczwara, M Miller
Breast cancer is the most common form of cancer amongst women. Women with breast cancer frequently consult dietitians for advice, and increasingly advice on complementary alternative medicines (CAM). The aim of this systematic review was to evaluate evidence of CAM administered orally on cancer-related outcomes. Databases were searched for studies recruiting women with a history of breast cancer reporting on the use of CAM administered orally as tablets, capsules, powders, and liquids for any 1 or more of the following: alleviation of cancer-related symptoms and treatment side effects, improvement to quality of life, physical and emotional wellbeing, survival, and mortality...
2015: Nutrition and Cancer
https://www.readbyqxmd.com/read/25790910/anti-diabetic-effects-of-ganoderma-lucidum
#13
Haou-Tzong Ma, Jung-Feng Hsieh, Shui-Tein Chen
Ganoderma lucidum is a white rot fungus widely used as a tonic for the promotion of longevity and health. Extracts of G. lucidum have been recognized as an alternative adjuvant treatment for diabetes. Among the many biologically active constituents of G. lucidum, polysaccharides, proteoglycans, proteins and triterpenoids have been shown to have hypoglycemic effects. G. lucidum polysaccharides have been reported to have hypoglycemic activity by increasing plasma insulin levels and decreasing plasma sugar levels in mice...
June 2015: Phytochemistry
https://www.readbyqxmd.com/read/25686270/ganoderma-lucidum-mushroom-for-the-treatment-of-cardiovascular-risk-factors
#14
REVIEW
Nerida L Klupp, Dennis Chang, Fiona Hawke, Hosen Kiat, Huijuan Cao, Suzanne J Grant, Alan Bensoussan
BACKGROUND: Ganoderma lucidum (also known as lingzhi or reishi) is a mushroom that has been consumed for its broad medicinal properties in Asia for over 2000 years. G lucidum is becoming increasingly popular in western countries as a complementary medicine for cardiovascular health. OBJECTIVES: To evaluate the effectiveness of G lucidum for the treatment of pharmacologically modifiable risk factors of cardiovascular disease in adults. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL Issue 6 of 12, 2014) on The Cochrane Library, MEDLINE (OVID, 1946 to June week 3 2014), EMBASE (OVID, 1980 to 2014 week 26), Science Direct (1823 to 2013), Current Controlled Trials (1990 to 2013), Australian New Zealand Clinical Trials Registry (2005 to 2013), Chinese Biomedical Literature Database (2007 to 2013), Chinese Medical Current Contents (2007 to 2013) and other databases...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25682509/genome-analysis-of-medicinal-ganoderma-spp-with-plant-pathogenic-and-saprotrophic-life-styles
#15
Ursula Kües, David R Nelson, Chang Liu, Guo-Jun Yu, Jianhui Zhang, Jianqin Li, Xin-Cun Wang, Hui Sun
Ganoderma is a fungal genus belonging to the Ganodermataceae family and Polyporales order. Plant-pathogenic species in this genus can cause severe diseases (stem, butt, and root rot) in economically important trees and perennial crops, especially in tropical countries. Ganoderma species are white rot fungi and have ecological importance in the breakdown of woody plants for nutrient mobilization. They possess effective machineries of lignocellulose-decomposing enzymes useful for bioenergy production and bioremediation...
June 2015: Phytochemistry
https://www.readbyqxmd.com/read/25361420/a-comprehensive-review-of-the-structure-elucidation-and-biological-activity-of-triterpenoids-from-ganoderma-spp
#16
REVIEW
Qing Xia, Huazheng Zhang, Xuefei Sun, Haijuan Zhao, Lingfang Wu, Dan Zhu, Guanghui Yang, Yanyan Shao, Xiaoxue Zhang, Xin Mao, Lanzhen Zhang, Gaimei She
Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. GTs are lanostane-tetracyclic triterpenes. They have been reported to possess anti-tumor, anti-inflammation, antioxidant, antimicrobial and blood fat reducing effects. To date, 316 GTs have been found and their similar chemical structures have proved difficult to elucidate. This paper compiles 316 naturally occurring triterpenes from Ganoderma based on the literature published through January 2013 along with their structures, physiological activities and 13C-NMR spectral data...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/24948193/suppression-of-inflammatory-and-allergic-responses-by-pharmacologically-potent-fungus-ganoderma-lucidum
#17
REVIEW
Neha Bhardwaj, Priya Katyal, Anil K Sharma
Acute inflammation is the result of a complex signal transduction pathway that protects and heals our body and is necessary for our good health and normal wellbeing. Whereas, chronic inflammation can be correlated well with the onset of a plethora of autoimmune disorders; rheumatoid arthritis, systemic lupus and polymyalgia, rheumatic and other diseases like asthma, inflammatory bowel diseases, cardiovascular disorders, ulcerative colitis and Crohn's disease. Also, it has been reported to be associated with the onset of various cancers...
2014: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/24790681/ganoderic-acid-dm-an-alternative-agent-for-the-treatment-of-advanced-prostate-cancer
#18
Benjamin M Johnson, Bently P Doonan, Faisal F Radwan, Azizul Haque
Prostate cancer is the most commonly diagnosed cancer in men and accounts for significant morbidity and mortality in the western world. While traditional therapies are effective at clearing early stage cancer, they often fail to treat late stage metastatic disease. Thus, an effective therapy that targets prostate tumor growth and metastasis is desired for alleviating the disease and improving patient outcomes. Natural extracts have been the focus of recent investigation, particularly those with reduced cellular toxicity to healthy tissue...
January 1, 2010: Open Prostate Cancer Journal
https://www.readbyqxmd.com/read/24716120/recent-progress-of-research-on-medicinal-mushrooms-foods-and-other-herbal-products-used-in-traditional-chinese-medicine
#19
REVIEW
Kuo-Hsiung Lee, Susan L Morris-Natschke, Xiaoming Yang, Rong Huang, Ting Zhou, Shou-Fang Wu, Qian Shi, Hideji Itokawa
This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms ( bā xī mó gū; Agaricus blazei, yún zhī; Coriolus versicolor, líng zhī; Ganoderma lucidum, xiāng xùn; shiitake, Lentinus edodes, niú zhāng zhī; Taiwanofungus camphoratus), Cordyceps ( dōng chóng xià cǎo), pomegranate ( shí liú; Granati Fructus), green tea ( lǜ chá; Theae Folium Non Fermentatum), garlic ( dà suàn; Allii Sativi Bulbus), turmeric ( jiāng huáng; Curcumae Longae Rhizoma), and Artemisiae Annuae Herba ( qīng hāo; sweet wormwood)...
April 2012: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/24654802/therapeutic-potential-of-culinary-medicinal-mushrooms-for-the-management-of-neurodegenerative-diseases-diversity-metabolite-and-mechanism
#20
REVIEW
Chia-Wei Phan, Pamela David, Murali Naidu, Kah-Hui Wong, Vikineswary Sabaratnam
Mushrooms have long been used not only as food but also for the treatment of various ailments. Although at its infancy, accumulated evidence suggested that culinary-medicinal mushrooms may play an important role in the prevention of many age-associated neurological dysfunctions, including Alzheimer's and Parkinson's diseases. Therefore, efforts have been devoted to a search for more mushroom species that may improve memory and cognition functions. Such mushrooms include Hericium erinaceus, Ganoderma lucidum, Sarcodon spp...
2015: Critical Reviews in Biotechnology
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