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subglottis stenosis

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https://www.readbyqxmd.com/read/29888684/eosinophilic-granulomatosis-with-polyangiitis-and-laryngeal-involvement-review-of-the-literature-and-a-cross-sectional-prospective-experience
#1
V Seccia, L Cristofani-Mencacci, I Dallan, S Fortunato, M L Bartoli, S Sellari-Franceschini, M Latorre, P L Paggiaro, C Baldini
BACKGROUND: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis show variable otorhinolaryngological involvement. Up to 14 per cent of granulomatosis with polyangiitis patients have subglottis involvement; little is known about the laryngeal involvement in eosinophilic granulomatosis with polyangiitis. METHOD: A literature review was conducted, together with a prospective cross-sectional analysis of 43 eosinophilic granulomatosis with polyangiitis patients...
June 11, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29808149/multimodality-surgical-approach-in-management-of-laryngotracheal-stenosis
#2
Ashfaque Ansari, Annju Thomas
Introduction: Postintubation laryngotracheal stenosis requires a precise diagnosis and an experienced operator in both endoscopic and surgical treatment. This report presents surgically treated cases of laryngotracheal stenosis secondary to long-term intubation/tracheostomy with review of the literature. Materials and Methods: In this retrospective study, we present 5 cases (a 23-year-old male, 13-year-old male, 22-year-old male, 19-year-old male, and 33-year-old female) of postintubation/tracheostomy laryngotracheal (glottic/subglottic) stenosis in the years 2016 and 2017...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29756352/outcomes-after-cricotracheal-resection-for-idiopathic-subglottic-stenosis
#3
Patrick S Carpenter, Jenny L Pierce, Marshall E Smith
OBJECTIVES: Idiopathic subglottic stenosis (iSGS) is a rare disease in which patients develop airway narrowing and dyspnea from relapsing subglottic and tracheal granulation and scar tissue that narrows the airway. Definitive management has involved surgical resection and reconstruction of the subglottis and trachea. However, treatment options remain highly variable at different institutions. Here, we present our outcomes and experience after cricotracheal resection (CTR) for iSGS at a high-volume tertiary care center...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29627053/laryngeal-split-and-rib-cartilage-interpositional-grafting-treatment-option-for-glottic-and-subglottic-stenosis-in-adults
#4
REVIEW
Wael Hasan, Patrick Gullane
Optimal management of tracheal stenosis depends on identifying causative factors. Risk factors include high tracheostomy, cricothyroidotomy, prolonged intubation, and proximal migration of an endotracheal tube cuff. Management ranges from conservative observation to endoscopic procedures or open surgical resections. The goal of surgical repair is an adequate airway, decannulation, and normal laryngeal function. For early stage disease, management of refractory conditions is via endoscopic procedures. An understanding of the respiratory function of the glottis and subglottis is essential when an optimum functional reconstruction of the glottic/subglottic area is considered...
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29224757/reproducing-severe-acute-subglottic-stenosis-in-a-rabbit-model
#5
Wesley R McIlwain, Paul R Wistermayer, Tyler P Swiss, Shannon T Marko, Nicholas M Ieronimakis, Derek J Rogers
OBJECTIVES: The objectives of this study were to develop an animal model with consistent, severe subglottic stenosis (SGS), and to develop the timeline needed for intervention to limit rabbit mortality. METHODS: Subglottic stenosis was created endoscopically using either a nylon or polypropylene brush in sixteen New Zealand White rabbits. The subglottic cross-sectional area was measured endoscopically using a right-angled probe and an open source image analysis software The cross-sectional areas of the stenotic and native airways were compared to calculate the subglottic stenosis percentage and Myer-Cotton grade classification...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29185355/the-effect-of-human-adipose-tissue-derived-mesenchymal-stem-cells-in-rat-s-subglottic-stenosis-model
#6
Seyeon Oh, Dong Young Kim, Min Kwan Baek, Kyunghee Byun, Joo Hyun Woo
OBJECTIVE: Subglottic stenosis remains a clinical challenge. The aim of this study was to evaluate the effect of human adipose tissue-derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis. SUBJECTS AND METHODS: Ninety-six 13-week-old male rats were enrolled in this study. They were divided into 3 groups as normal control (NC) group, a subglottic injury and media injection (SM) group, and a subglottic injury and media-stem cell injection (SMSC) group...
January 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29171660/relationship-between-degree-of-obstruction-and-airflow-limitation-in-subglottic-stenosis
#7
Emily L Lin, Jonathan M Bock, Carlton J Zdanski, Julia S Kimbell, Guilherme J M Garcia
OBJECTIVES: Subglottic stenosis (SGS) is one of the most common airway disorders in pediatric patients. Currently, treatment decisions rely primarily on the Cotton-Myer scale, which classifies SGS severity based on percentage reduction in airspace cross-sectional area (CSA). However, the precise relationship between upper airway resistance and subglottic CSA is unknown. We hypothesize that airway resistance can be described by the Bernoulli Obstruction Theory, which predicts that airway resistance is inversely proportional to airspace CSA ( R∝A-1) in cases of severe constriction...
November 24, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28988454/awake-serial-intralesional-steroid-injections-without-surgery-as-a-novel-targeted-treatment-for-idiopathic-subglottic-stenosis
#8
Ramon A Franco, Inna Husain, Lindsay Reder, Paul Paddle
OBJECTIVES/HYPOTHESIS: The fibrotic/erythematous appearance of the subglottis in idiopathic subglottic stenosis (iSGS) hints that it might respond to repeated intralesional steroid treatment similar to keloids. STUDY DESIGN: Retrospective cohort study. METHODS: Thirteen iSGS subjects (six treated in-office with serial intralesional steroid injections [SILSI] versus seven treated endoscopically in the operating room [OR] followed by awake SILSI) between October 2011 and April 2017...
March 2018: Laryngoscope
https://www.readbyqxmd.com/read/28988443/effects-of-supramaximal-balloon-dilatation-pressures-on-adult-cricoid-and-tracheal-cartilage-a-cadaveric-study
#9
Venkata S P B Durvasula, Sara C Shalin, Ozlem E Tulunay-Ugur, James Y Suen, Gresham T Richter
OBJECTIVES/HYPOTHESIS: Cricoid fracture is a serious concern for balloon dilatation in airway stenosis. Furthermore, there are no studies examining tracheal rupture in balloon dilatation of stenotic segments. The aim of this study was to evaluate the effect of supramaximal pressures of balloons on the cricoid and tracheal rings. STUDY DESIGN: Prospective cadaveric study. METHODS: Seven cadaveric laryngotracheal complexes of normal adults with intact cricothyroid membranes were acquired...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28929076/role-of-topical-medication-in-prevention-of-post-extubation-subglottic-stenosis
#10
Saravanam Prasanna Kumar, Arunachalam Ravikumar, Johnson Thanka
Iatrogenic laryngotracheal injury is the most serious complication of endotracheal intubation since this method of establishing airway was first described by Eugene Bouchut in 1858. Even today, subglottic stenosis is the most dreaded complication of intubation. This animal study is focused on the host tissue response to intubation induced injury resulting in subglottic stenosis and methods to prevent this complication. To assess the role of topically applied Mitomycin-C and Triamcinolone Acetonide in wound healing process following post-extubation subglottic injury...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28715559/interferon-%C3%AE-treatment-of-human-laryngotracheal-stenosis-derived-fibroblasts
#11
Kevin Motz, Idris Samad, Linda X Yin, Michael K Murphy, Madhavi Duvvuri, Dacheng Ding, Alexander T Hillel
Importance: Laryngotracheal stenosis (LTS) is a fibroproliferative disorder of the glottis, subglottis, and trachea. In models of fibrosis from other organ systems, the CD4+ T-cell response has been shown to regulate extracellular matrix deposition. Specifically, helper T cell 2 (TH2) promotes fibrosis, whereas TH1 and associated cytokines have been shown to be antifibrotic. However, this antifibrotic effect of the TH1 response has not been demonstrated in LTS. Objective: To determine whether the TH1 cytokine interferon-γ inhibits the function of LTS-derived fibroblasts in vitro...
November 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28620493/a-bronchoscopic-approach-to-benign-subglottic-stenosis
#12
Tuhina Raman, Kshitij Chatterjee, Bashar N Alzghoul, Ayoub A Innabi, Ozlem Tulunay, Thaddeus Bartter, Nikhil K Meena
OBJECTIVES: Subglottic stenosis is an abnormal narrowing of the tracheal lumen at the level of subglottis (the area in between the vocal cords and the cricoid cartilage). It can cause significant symptoms due to severe attenuation of airflow. We describe our experience in alleviating symptoms by addressing the stenosis using fibreoptic bronchoscopic methods. METHODS: We report all concurrent cases performed between September 2015 and July 2016. We use a combination of balloon dilation, electro-surgery knife to dilate and incise stenotic segments followed by steroid injection to modulate healing...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/28480810/traumatic-laryngotracheal-stenosis-treated-by-hyoid-sternohyoid-osseomuscular-flap-combined-with-xenogenic-acellular-dermal-matrix-a-case-report-and-literature-review
#13
Hang Yang, Zhe Chen, Shui-Hong Zhou, Qin-Yin Wang, Li-Xia Weng, Fang Wang, Ting-Ting Wu, Min-Li Zhou, Yang-Yang Bao
Objective The treatment of laryngotracheal stenosis is a major therapeutic challenge. Various treatments include observation, medical management, and surgical management. The most effective surgical management is resection and reconstruction. To the authors' knowledge, no reports have described the use of xenogenic acellular dermal matrix (ADM) for laryngotracheal stenosis. Methods A 27-year-old man presented with hemoptysis of the neck due to a traffic accident. Emergency orotracheal intubation was performed...
October 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28472351/the-benefits-and-limitations-of-targeted-training-in-flexible-transnasal-laryngoscopy-diagnosis
#14
Kimberly A Russell, Christopher D Brook, Michael P Platt, Gregory A Grillone, Avner Aliphas, J Pieter Noordzij
Importance: Targeted laryngoscopy training can be used successfully in de novo learners. Objective: To determine the value of targeted laryngoscopy education in interns. Design, Setting, and Participants: This prospective study of fiberoptic laryngoscopy interpretations enrolled 13 participants in an academic hospital setting from August 1 to December 31, 2015. Participants included 10 postgraduate year 1 emergency and otolaryngology interns and 3 board-certified otolaryngology attending physicians...
July 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28095939/safe-balloon-sizing-for-endoscopic-dilatation-of-subglottic-stenosis-in-children
#15
S D Sharma, S L Gupta, M Wyatt, D Albert, B Hartley
OBJECTIVES: To describe our experience and provide guidelines for maximum safe balloon sizes according to age in children undergoing balloon dilatation. METHOD: A retrospective review was conducted of children undergoing balloon dilatation for subglottic stenosis in a paediatric tertiary unit between May 2006 and February 2016. RESULTS: A total of 166 patients underwent balloon dilatation. Mean ( ± standard deviation) patient age was 4.5 ± 3...
March 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27559721/diagnosis-of-subglottic-stenosis-in-a-rabbit-model-using-long-range-optical-coherence-tomography
#16
Olubunmi Ajose-Popoola, Erica Su, Ashley Hamamoto, Alex Wang, Joseph C Jing, Tony D Nguyen, Jason J Chen, Kathryn E Osann, Zhongping Chen, Gurpreet S Ahuja, Brian J F Wong
OBJECTIVES/HYPOTHESIS: Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. STUDY DESIGN: Prospective animal study in rabbits. METHODS: Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture...
January 2017: Laryngoscope
https://www.readbyqxmd.com/read/27553595/can-pfts-differentiate-pvfmd-from-subglottic-stenosis
#17
Liuba Soldatova, Candace Hrelec, Laura Matrka
OBJECTIVE: To determine if the results of routine spirometry and flow volume loops (Pulmonary Function Tests (PFTs)) can be used to distinguish Paradoxic Vocal Fold Movement Disorder (PVFMD) from Subglottic Stenosis (SGS). METHODS: PFT records and medical history of 49 patients with diagnosis of PVFMD and 39 patients with SGS were compared. Groups were then subdivided to compare PFTs in patients with and without smoking history or lung disease. RESULTS: Peak expiratory flow rate (PEFR) and Expiratory Disproportion Index (ratio of forced expiratory volume in 1 second (FEV1) over PEFR (FEV1/PEFR)) were both significantly different between patients with SGS and those with PVFMD (p<0...
December 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27508129/challenges-in-the-management-of-laryngeal-stenosis
#18
Satish Nair, Ajith Nilakantan, Amit Sood, Atul Gupta, Abhishek Gupta
Laryngeal stenosis is one of the most complex and challenging problems in the field of head and neck surgery. The management involves a multidisciplinary approach with multiple complex procedures. In this study we discuss our experience of laryngeal stenosis with regards to patient characteristics, cause and management. A retrospective analysis of 35 patients of laryngeal stenosis treated at a tertiary care centre was evaluated. Inclusion criteria were all patients with laryngeal stenosis who required surgical intervention...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27354215/quantitative-evaluation-of-adult-subglottic-stenosis-using-intraoperative-long-range-optical-coherence-tomography
#19
Giriraj K Sharma, Anthony Chin Loy, Erica Su, Joe Jing, Zhongping Chen, Brian J-F Wong, Sunil Verma
OBJECTIVES: To determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS). METHODS: Long-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlaryngoscopy before and after endoscopic treatment for SGS. The anteroposterior and transverse diameters, cross-sectional area (CSA), distance from the vocal cords, and length of the SGS were measured using a MATLAB software...
October 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27301599/subglottic-stenosis
#20
REVIEW
Niall D Jefferson, Aliza P Cohen, Michael J Rutter
Subglottic stenosis (SGS) is a congenital or acquired condition characterized by a narrowing of the upper airway extending from just below the vocal folds to the lower border of the cricoid cartilage. With the introduction of prolonged intubation in neonates (mid 1960s), acquired SGS became the most frequent cause of laryngeal stenosis; unlike congenital SGS, it does not improve with time. Laryngeal reconstruction surgery evolved as a consequence of the need to manage these otherwise healthy but tracheotomized children...
June 2016: Seminars in Pediatric Surgery
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