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https://www.readbyqxmd.com/read/29330507/uncovering-the-anticancer-mechanism-of-compound-kushen-injection-against-hcc-by-integrating-quantitative-analysis-network-analysis-and-experimental-validation
#1
Li Gao, Ke-Xin Wang, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin, Guan-Hua Du
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines, the active compounds, potential targets and pathways involved in these effects have not been systematically investigated. Here, we proposed a novel idea of "main active compound-based network pharmacology" to explore the anti-cancer mechanism of CKI...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327548/-research-of-tcm-synthetic-rehabilitation-on-the-recovery-of-wrist-joint-after-distal-radius-fractures
#2
Yong Zhao, Qing-Qing Dong, Wei-Kai Qin, An Yan, Kuan Zhang, Guo-Dong Zhao, Gang Wang, Jin-Chao Geng, Zhan-Feng Wang, Ze-Ming Lu
OBJECTIVE: To evaluate efficacy and advantages of the Traditional Chinese Medicine (TCM) synthetic rehabilitation therapy in the treatment of wrist dysfunction after distal radius fractures. METHODS: From May 2014 to October 2015, 72 patients with distal radius fracture meeting standards were treated using central randomization system for clinical research. All the patients were divided into two groups: 36 patients in test group and 36 in control group. Sixty-nine cases were finished treatment and followed up in the end...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29323538/clinical-characteristics-and-outcomes-of-traditional-chinese-medicine-induced-liver-injury-a-systematic-review
#3
Ran Wang, Xingshun Qi, Eric Yoshida, Nahum Mendez-Sanchez, Rolf Teschke, Mingyu Sun, Xu Liu, Chunping Su, Jiao Deng, Han Deng, Feifei Hou, Xiaozhong Guo
BACKGROUNDS: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated. AIMS: This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI). METHODS: China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched...
January 11, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29321719/cancer-chemoprevention-and-therapy-using-chinese-herbal-medicine
#4
REVIEW
Lijing Jiao, Ling Bi, Yan Lu, Qin Wang, Yabin Gong, Jun Shi, Ling Xu
Traditional Chinese medicine (TCM) plays an indispensable role in cancer prevention and treatment. Chinese herbal medicine (CHM) is a key component of TCM and has been practiced for thousands of years. A number of naturally occurring products from Chinese herbs extracts exhibit strong inhibitory properties against carcinogenesis, including CHM single-herb extracts, CHM-derived active components, and CHM formulas (the polyherbal combinations), which regulate JAK/STAT, MAPK, and NF-ҡB pathways. The present review aims to report the cancer-preventive effect of CHM with evidence from cell-line, animal, epidemiological, and clinical experiments...
2018: Biological Procedures Online
https://www.readbyqxmd.com/read/29321678/systems-pharmacology-analysis-of-synergy-of-tcm-an-example-using-saffron-formula
#5
Jianling Liu, Jingjing Liu, Fengxia Shen, Zonghui Qin, Meng Jiang, Jinglin Zhu, Zhenzhong Wang, Jun Zhou, Yingxue Fu, Xuetong Chen, Chao Huang, Wei Xiao, Chunli Zheng, Yonghua Wang
Traditional Chinese medicine (TCM) follows the principle of formulae, in which the pharmacological activity of a single herb can be enhanced or potentiated by addition of other herbs. Nevertheless, the involved synergy mechanisms in formulae remain unknown. Here, a systems-based method is proposed and applied to three representative Chinese medicines in compound saffron formula (CSF): two animal spices (Moschus, Beaver Castoreum), and one herb Crocus sativus which exert synergistic effects for cardiovascular diseases (CVDs)...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320397/in-silico-analysis-of-the-association-relationship-between-neuroprotection-and-flavors-of-traditional-chinese-medicine-based-on-the-mglurs
#6
Xu Zhang, Liansheng Qiao, Yankun Chen, Bowen Zhao, Yu Gu, Xiaoqian Huo, Yanling Zhang, Gongyu Li
The metabotropic glutamate receptors (mGluRs) are known as both synaptic receptors and taste receptors. This feature is highly similar to the Property and Flavor theory of Traditional Chinese medicine (TCM), which has the pharmacological effect and flavor. In this study, six ligand based pharmacophore (LBP) models, seven homology modeling models, and fourteen molecular docking models of mGluRs were built based on orthosteric and allosteric sites to screening potential compounds from Traditional Chinese Medicine Database (TCMD)...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29318814/-information-work-of-national-census-of-traditional-chinese-medicine-resources
#7
Lu-Qi Huang, Xiao-Bo Zhang
In order to promote the protection, development and rational utilization on traditional Chinese medicine resources (TCM resoueces), the State Administration of Traditional Chinese Medicine is organizing and implementing the fourth national survey on TCM resources. Informatization is the core for this survey and is also one of the main innovative points which transcend the previous three surveys. The extensive application on informatization technology has not only improved the work efficiency of the survey, but also expanded the new development directions of TCM resources research...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29316796/scutellaria-baicalensis-and-cancer-treatment-recent-progress-and-perspectives-in-biomedical-and-clinical-studies
#8
Chien-Shan Cheng, Jie Chen, Hor-Yue Tan, Ning Wang, Zhen Chen, Yibin Feng
Scutellaria baicalensis (Huangqin in Chinese) is a major traditional Chinese medicine (TCM) herb, which has a long history of use in the treatment of a variety of symptoms correlated with cancer. In the past decade, the potential of S. baicalensis and single compounds derived from it as anticancer agents targeting various pathways has received extensive research attention. Specifically, the proliferation and metastases inhibiting properties of the single compounds in cancer have been studied; however, the underlying mechanisms remain unclear...
January 9, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29312602/tanshinone-iia-inhibits-angiogenesis-in-human-endothelial-progenitor-cells-in-vitro-and-in-vivo
#9
Hsiang-Ping Lee, Yueh-Ching Liu, Po-Chun Chen, Huai-Ching Tai, Te-Mao Li, Yi-Chin Fong, Chih-Shiang Chang, Min-Huan Wu, Li-Pin Chiu, Chia-Jung Wang, Yi-Hsuan Chen, Yih-Jer Wu, Chih-Hsin Tang, Shih-Wei Wang
Accumulating evidence reports that bone marrow-derived endothelial progenitor cells (EPCs) regulate angiogenesis, postnatal neovascularization and tumor metastasis. It has been suggested that understanding the molecular targets and pharmacological functions of natural products is important for novel drug discovery. Tanshinone IIA is a major diterpene quinone compound isolated from Danshen (Salvia miltiorrhiza) and is widely used in traditional Chinese medicine (TCM). Evidence indicates that tanshinone IIA modulates angiogenic functions in human umbilical vein endothelial cells...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310390/takotsubo-cardiomyopathy-caused-by-acute-respiratory-stress-from-extubation-a-case-report
#10
Kohei Taniguchi, Syogo Takashima, Ryo Iida, Koshi Ota, Masahiko Nitta, Kazushi Sakane, Tomohiro Fujisaka, Nobukazu Ishizaka, Osamu Umegaki, Kazuhisa Uchiyama, Akira Takasu
RATIONAL: Takotsubo cardiomyopathy (TCM) is a transient systolic dysfunction of the left ventricular apex without stenosis of coronary arteries and is induced by various psychological and physical factors. TCM sometimes causes lethal complications such as arrhythmia, thrombogenesis, and even cardiac rupture, and thus it should be diagnosed appropriately and managed carefully. Intensive care unit (ICU) patients are exposed to overstress during the treatment process and therefore can are at potential risk for TCM...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310050/explore-the-effects-of-huang-lian-jie-du-tang-on-alzheimer-s-disease-by-uplc-qtof-ms-based-plasma-metabolomics-study
#11
Li-Min Sun, Bao-Jie Zhu, Hui-Ting Cao, Xin-Yi Zhang, Qi-Chun Zhang, Gui-Zhong Xin, Lin-Mei Pan, Li-Fang Liu, Hua-Xu Zhu
Alzheimer's disease (AD) is a progressive neurodegenerative disease with neither definitive pathogenesis nor effective treatment method so far. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic formula of traditional Chinese medicine (TCM) proven to have ameliorative effects on learning and memory deficits of dementia. Morris water maze (MWM) test and pathology analysis have demonstrated that HLJDT could ameliorate learning and memory deficits in AD mouse model, which may act via its anti-neuroinflammation properties...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29305931/discrimination-of-three-siegesbeckiae-herba-species-using-uplc-qtof-ms-based-metabolomics-approach
#12
Hong-Xun Tao, Wei Xiong, Guan-Ding Zhao, Yu Peng, Zhang-Feng Zhong, Liang Xu, Ran Duan, Karl W K Tsim, Hua Yu, Yi-Tao Wang
The plant origin is one of the most important factors for the quality control of traditional Chinese medicines (TCMs) and highly affected on their safety and effectiveness in clinical applications. Multi-origin has been widely observed for many TCMs. Siegesbeckiae Herba (SH) is a traditional anti-rheumatic TCM which is originated from the plants of Siegesbeckia pubescens Makino (SP), S. orientalis L. (SO), and S. glabrescens Makino (SG). In the present study, an UPLC-QTOF/MS method were validated and successfully applied for the determination of the chemical profiles in the three SH species...
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29300975/new-application-of-dydrogesterone-as-a-part-of-a-progestin-primed-ovarian-stimulation-protocol-for-ivf-a-randomized-controlled-trial-including-516-first-ivf-icsi-cycles
#13
Sha Yu, Hui Long, Hannah Ya-Ning Chang, Yali Liu, Hongyuan Gao, Jing Zhu, Xinxin Quan, Qifeng Lyu, Yanping Kuang, Ai Ai
STUDY QUESTION: Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? SUMMARY ANSWER: DYG can be used as an appropriate alternative progestin in a PPOS protocol. WHAT IS KNOWN ALREADY: PPOS is a new ovarian stimulation regimen based on a freeze-all strategy that uses progestin as an alternative to a GnRH analog for suppressing a premature LH surge during the follicular phase...
December 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29287265/nmr-based-metabolomic-comparison-of-the-antitussive-and-expectorant-effect-of-farfarae-flos-collected-at-different-stages
#14
Jing Li, Zheng-Zheng Zhang, Zhen-Hong Lei, Xue-Mei Qin, Zhen-Yu Li
Farfarae Flos (FF) is widely used for the treatment of cough, bronchitis, and asthmatic disorders in the Traditional Chinese Medicine (TCM). According to the experience of TCM, only the flower bud can be used as herbal drug, and its medicinal quality becomes lower after blooming. However, the underlying scientific basis for this phenomenon is not fully understood. In this study, the chemical components and the bioactivities of the FF collected at three different development stages were compared systematically...
December 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29284520/chinese-herbal-medicine-tangbi-formula-treatment-of-patients-with-type-2-diabetic-distal-symmetric-polyneuropathy-disease-study-protocol-for-a-randomized-controlled-trial
#15
De Jin, Wen-Jing Huang, Xiang Meng, Fan Yang, Yu-Jiao Zheng, Qi Bao, Mei-Zhen Zhang, Ya-Nan Yang, Qing Ni, Feng-Mei Lian, Xiao-Lin Tong
BACKGROUND: Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirely satisfactory. Preliminary studies indicated that the Chinese herbal TangBi Formula may alleviate signs and symptoms and improve the velocity of nerve conduction in patients with DSPN...
December 29, 2017: Trials
https://www.readbyqxmd.com/read/29280021/clinical-features-and-neurosurgical-treatment-of-trigonal-cavernous-malformations
#16
Chengjun Wang, Meng Zhao, Xiaofeng Deng, Jia Wang, Zhongli Jiang, Jizong Zhao
The goals of this study were to analyze the incidence, clinical manifestations, neuroimaging findings, surgical treatments, and neurological outcomes of trigonal cavernous malformations (TCMs). Among 1395 cases of intracranial and intraspinal cavernous malformations (CMs) surgically treated between 2003 and 2016 at Beijing Tiantan Hospital, a series of 12 patients with TCM was chosen for analysis and their records were reviewed. We also performed an exhaustive literature search using PubMed to identify all previously reported cases in the literatures...
December 26, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29278981/delivering-occupational-therapy-hand-assessment-and-treatment-sessions-via-telehealth
#17
Tess Worboys, Melinda Brassington, Elizabeth C Ward, Petrea L Cornwell
Introduction Telehealth offers a solution to assist delivery of occupational therapy (OT) services for hand therapy in rural and remote locations. However, there is currently no evidence to validate this service model. The aim of this study was to examine the validity of clinical decisions made during hand therapy sessions conducted via telehealth compared to a traditional clinical model (TCM) assessment, and explore patient and clinician satisfaction. Methods Eighteen patients referred for hand therapy to a rural/remote hospital-based outpatient service were assessed simultaneously via telehealth and a TCM assessment...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29278229/is-there-any-difference-between-the-distances-created-by-towel-clamp-lifting-and-towel-clamp-plus-manual-lifting-of-the-anterior-abdominal-wall-for-direct-trocar-entry-in-laparoscopic-gynecologic-surgery-a-prospective-interventional-study
#18
Taner A Usta, Tolga Karacan, Evrim Ebru Kovalak, Ulviye Hanlı, M Murat Naki
OBJECTIVE: Most surgeons prefer to perform anterior abdominal wall lifting during abdominal entry to avoid damage to intestines or main vessels. Anterior abdominal wall lifting is assumed to prevent vital organ injuries by creating an adequate distance prior to entry into the peritoneal cavity. In this study, we compared the distance created for trocar entry into the peritoneal cavity with towel clamp lifting and towel clamp plus manual elevation of the anterior abdominal wall. MATERIAL AND METHODS: Forty patients who underwent various laparoscopic procedures were enrolled...
December 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29277765/traditional-chinese-medicine-curcumin-sensitizes-human-colon-cancer-to-radiation-by-altering-the-expression-of-dna-repair-related-genes
#19
Guangen Yang, Jianming Qiu, Dong Wang, Yong Tao, Yihuan Song, Hongtao Wang, Juping Tang, Xing Wang, Y U Sun, Zhijian Yang, Robert M Hoffman
BACKGROUND/AIM: The aim of the present study was to investigate the radio-sensitizing efficacy of curcumin, a traditional Chinese medicine (TCM) on colon cancer cells in vitro and in vivo. MATERIALS AND METHODS: Human colon cancer HT-29 cells were treated with curcumin (2.5 μM), irradiation (10 Gy) and the combination of irradiation and curcumin. Cell proliferation was assessed using the MTT assay. Apoptotic cells were detected by Annexin V-PE/7-AAD analysis. PCR was performed to determine differential-expression profiling of 95 DNA-repair genes in irradiated cells and cells treated with both irradiation and curcumin...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29274797/an-inverse-method-to-estimate-emission-rates-based-on-nonlinear-least-squares-based-ensemble-four-dimensional-variational-data-assimilation-with-local-air-concentration-measurements
#20
Xiaobing Geng, Zhenghui Xie, Lijun Zhang, Mei Xu, Binghao Jia
An inverse source estimation method is proposed to reconstruct emission rates using local air concentration sampling data. It involves the nonlinear least squares-based ensemble four-dimensional variational data assimilation (NLS-4DVar) algorithm and a transfer coefficient matrix (TCM) created using FLEXPART, a Lagrangian atmospheric dispersion model. The method was tested by twin experiments and experiments with actual Cs-137 concentrations measured around the Fukushima Daiichi Nuclear Power Plant (FDNPP)...
December 21, 2017: Journal of Environmental Radioactivity
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