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https://www.readbyqxmd.com/read/29752446/gwas-highlights-challenges-associated-with-identification-of-dkd-risk-variants
#1
Susan J Allison
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29736201/niclosamide-ethanolamine-improves-diabetes-and-diabetic-kidney-disease-in-mice
#2
Pengxun Han, Mumin Shao, Lan Guo, Wenjing Wang, Gaofeng Song, Xuewen Yu, Chunlei Zhang, Na Ge, Tiegang Yi, Shunmin Li, Heng Du, Huili Sun
Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). Evidence has suggested that niclosamide ethanolamine salt (NEN) could improve diabetic symptoms in mice of type 2 diabetes (T2D). However, its role in T1D and DKD has not been studied to date. Here we report that NEN could protect against diabetes in streptozotocin (STZ) induced T1D mice. It increased serum insulin levels, corrected the unbalanced ratio of α-cells to β-cells, and induced islet morphologic changes under diabetic conditions...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29729375/clinical-predictive-biomarkers-for-normoalbuminuric-diabetic-kidney-disease
#3
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
AIMS: A portion of patients with diabetes mellitus follow the progression of a non-albuminuria-based pathway; i.e., normoalbuminuric diabetic kidney disease (NA-DKD). However, the risk factors which determine NA-DKD are not yet fully understood. This cross-sectional study was therefore aimed to investigate the association between various biomarker levels and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus and normoalbuminuria (T2D-NA). METHODS: We measured cardiovascular disease (CVD) [serum osteoprotegerin (OPG), plasma brain natriuretic peptide (BNP), cardio-ankle vascular index (CAVI)], tubular damage [urinary L-type fatty acid binding protein (L-FABP)], and inflammatory [serum tumornecrosis factor (TNF) α and its receptors (TNFRs)] biomarkers in 314 patients with T2D-NA...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29717107/exendin-4-ameliorates-high-glucose-induced-fibrosis-by-inhibiting-the-secretion-of-mir-192-from-injured-renal-tubular-epithelial-cells
#4
Yijie Jia, Zongji Zheng, Meiping Guan, Qian Zhang, Yang Li, Ling Wang, Yaoming Xue
Extracellular vesicles (EVs), which contain microRNA (miRNA), constitute a novel means of cell communication that may contribute to the inevitable expansion of renal fibrosis during diabetic kidney disease (DKD). Exendin-4 is effective for treating DKD through its action on GLP1R. However, the effect of exendin-4 on EV miRNA expression and renal cell communication during the development of DKD remains unknown. In this study, we found that EVs derived from HK-2 cells pre-treated with exendin-4 and high glucose (Ex-HG), which were taken up by normal HK-2 cells, resulted in decreased levels of FN and Col-I compared with EVs from HK-2 cells pre-treated with HG alone...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29712934/elevated-urinary-n-acetyl-%C3%AE-d-glucosaminidase-is-associated-with-high-glycoalbumin-to-hemoglobin-a1c-ratio-in-type-1-diabetes-patients-with-early-diabetic-kidney-disease
#5
Namki Hong, Minyoung Lee, Soyoung Park, Yong-Ho Lee, Sang-Man Jin, Jae Hyeon Kim, Byung-Wan Lee
Urinary N-acetyl-β-D-glucosaminidase (uNAG) predicted the progression of diabetic kidney disease (DKD) prior to development of albuminuria in diabetes patients. We sought whether uNAG level is associated with glycoalbumin-to-hemoglobin A1c ratio (G/A ratio), a marker of postprandial hyperglycemia and glycemic excursion, independent of albuminuria and kidney function. The association between uNAG excretion and G/A ratio was assessed in 204 consecutive subjects with type 1 diabetes (T1D) (mean age 43.9 years; 49...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29704532/mdm2-controls-nrf2-antioxidant-activity-in-prevention-of-diabetic-kidney-disease
#6
Weiying Guo, Dan Tian, Ye Jia, Wenlin Huang, Mengnan Jiang, Junnan Wang, Weixia Sun, Hao Wu
Oxidative stress and P53 contribute to the pathogenesis of diabetic kidney disease (DKD). Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of cellular antioxidant defense system, is negatively regulated by P53 and prevents DKD. Recent findings revealed an important role of mouse double minute 2 (MDM2) in protection against DKD. However, the mechanism remained unclear. We hypothesized that MDM2 enhances NRF2 antioxidant signaling in DKD given that MDM2 is a key negative regulator of P53...
April 25, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29703844/a-genome-wide-association-study-of-diabetic-kidney-disease-in-subjects-with-type-2-diabetes
#7
Natalie R van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R Robertson, Paul M McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M Loredana Marcovecchio, Robert P Igo, Rany M Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M van Dam, Guozhi Jiang, Claudia H T Tam, Andrea O Y Luk, Heung Man Lee, Cadmon K P Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C N Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G Pezzolesi, Genie Consortium, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T Hiraki, Tarunveer S Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D Paterson, David Tregouet, Alexander P Maxwell, Su Chi Lim, Ronald C W Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S Krolewski, Stephen S Rich, Joel N Hirschhorn, Jose C Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N A Palmer, Per-Henrik Groop, Helen M Colhoun, Leif C Groop, Mark I McCarthy
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD)...
April 27, 2018: Diabetes
https://www.readbyqxmd.com/read/29702558/a-low-protein-diet-for-diabetic-kidney-disease-its-effect-and-molecular-mechanism-an-approach-from-animal-studies
#8
REVIEW
Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya
A low-protein diet (LPD) can be expected to retard renal function decline in advanced stages of chronic kidney disease (CKD), including diabetic kidney disease (DKD), and is recommended in a clinical setting. Regarding the molecular mechanisms of an LPD against DKD, previous animal studies have shown that an LPD exerts reno-protection through mainly the improvement of glomerular hyperfiltration/hypertension due to the reduction of intraglomerular pressure. On the other hand, we have demonstrated that an LPD, particularly a very-LPD (VLPD), improved tubulo-interstitial damage, inflammation and fibrosis, through the restoration of autophagy via the reduction of a mammalian target of rapamycin complex 1 (mTORC1) activity in type 2 diabetes and obesity animal models...
April 27, 2018: Nutrients
https://www.readbyqxmd.com/read/29689479/lipo-prostaglandin-e1-improves-renal-hypoxia-evaluated-by-bold-mri-in-patients-with-diabetic-kidney-disease
#9
Zhi-Cheng Li, Yu-Zhe Cai, Zhi-Gang Tang, Pan-Li Zuo, Rong-Bo Liu, Fang Liu
OBJECTIVE: To evaluate the effect of lipo-PGE1 on renal hypoxia in patients with DKD by BOLD-MRI. MATERIALS AND METHODS: All patients were divided into DKD group and CKD-without-diabetes group. All patients received intravenous 10 μg lipo-PGE1 once daily for 14 days. BOLD-MRI was performed before and after lipo-PGE1 administration to acquire renal CR2* and MR2* values. RESULTS: Renal MR2* value in DKD group after lipo-PGE1 treatment were significantly decreased compared with the baseline...
April 17, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29686650/glucose-transporters-in-diabetic-kidney-disease-friends-or-foes
#10
REVIEW
Anita A Wasik, Sanna Lehtonen
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a common cause of end-stage renal disease worldwide. DKD manifests as an increased urinary protein excretion (albuminuria). Multiple studies have shown that insulin resistance correlates with the development of albuminuria in non-diabetic and diabetic patients. There is also accumulating evidence that glomerular epithelial cells or podocytes are insulin sensitive and that insulin signaling in podocytes is essential for maintaining normal kidney function...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29684848/protective-effects-of-ifn-%C3%AE-on-the-kidney-of-type-2-diabetic-kkay-mice
#11
Juan Du, Wenpeng Dong, Huifeng Li, Bo Li, Xiaodan Liu, Qinghui Kong, Wei Sun, Tingli Sun, Peilong Ma, Yan Cui, Ping Kang
BACKGROUND: Development of novel therapeutic strategies that specifically target diabetic kidney disease (DKD) is urgently needed. METHODS: Male KKAy mice were divided randomly into three equal groups - KK, KI, and KF; Male C57BL/6 mice were the control group. All KKAy mice were fed a high-fat diet. From the 16th week, the KI group was given IFN-γ, and the KF group was assigned to be treated with fludarabine. C57BL/6 mice were always fed a normal mouse diet. Every 4 weeks, body weight, random blood sugar, urine albumin and urea of all mice were measured...
December 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29681936/metformin-regulating-mir-34a-pathway-to-inhibit-egr1-in-rat-mesangial-cells-cultured-with-high-glucose
#12
Can Wu, Ningning Qin, Huiwen Ren, Min Yang, Shuang Liu, Qiuyue Wang
Background: Activating AMPK α negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK α through mediating SIRT1 to suppress the development of fatty liver. Aim of the Study: To clarify the function of Egr1 on the inflammation and fibrosis in high glucose-cultured MCs, as well as to explore the effects of metformin on miR-34a pathway and Egr1 expression. Methods: We transfected MCs with miR-34a inhibitor...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29674631/orally-active-species-independent-novel-a-3-adenosine-receptor-antagonist-protects-against-kidney-injury-in-db-db-mice
#13
Debra Dorotea, Ahreum Cho, Gayoung Lee, Guideock Kwon, Junghwa Lee, Pramod K Sahu, Lak Shin Jeong, Dae Ryong Cha, Hunjoo Ha
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and the current pharmacological treatment for DKD is limited to renin-angiotensin system (RAS) inhibitors. Adenosine is detectable in the kidney and is significantly elevated in response to cellular damage. While all 4 known subtypes of adenosine receptors, namely, A1 AR, A2a AR, A2b AR, and A3 AR, are expressed in the kidney, our previous study has demonstrated that a novel, orally active, species-independent, and selective A3 AR antagonist, LJ-1888, ameliorates unilateral ureteral obstruction-induced tubulointerstitial fibrosis...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29667906/detection-of-dkd-stage-1-and-treatment-are-essential
#14
Narisa Futrakul, Prasit Futrakul
No abstract text is available yet for this article.
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29665833/intervention-using-vitamin-d-for-elevated-urinary-albumin-in-type-2-diabetes-mellitus-ideal-2-study-study-protocol-for-a-randomised-controlled-trial
#15
Shahrad Taheri, Muhammad Asim, Hassan Al Malki, Omar Fituri, Manikkam Suthanthiran, Phyllis August
BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. T2DM is associated with serious macro- and microvascular complications. In particular, diabetic kidney disease (DKD), which begins with excessive urinary albumin excretion, has a significant impact on affected individuals and is costly to healthcare services. Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) significantly reduces albuminuria in diabetes, but this effect is not observed in all those treated...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29649631/simultaneous-risk-factor-control-using-telehealth-to-slow-progression-of-diabetic-kidney-disease-stop-dkd-study-protocol-and-baseline-characteristics-of-a-randomized-controlled-trial
#16
Clarissa J Diamantidis, Hayden B Bosworth, Megan M Oakes, Clemontina A Davenport, Jane F Pendergast, Sejal Patel, Jivan Moaddeb, Huiman X Barnhart, Peter D Merrill, Khaula Baloch, Matthew J Crowley, Uptal D Patel
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the United States. Multiple risk factors contribute to DKD development, yet few interventions target more than a single DKD risk factor at a time. This manuscript describes the study protocol, recruitment, and baseline participant characteristics for the Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD) study. The STOP-DKD study is a randomized controlled trial designed to evaluate the effectiveness of a multifactorial behavioral and medication management intervention to mitigate kidney function decline at 3 years compared to usual care...
April 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29629372/glomerular-endothelial-cells-stress-and-cross-talk-with-podocytes-in-the-development-of-diabetic-kidney-disease
#17
REVIEW
Ilse Sofia Daehn
Diabetic kidney disease (DKD) is one of the major causes of morbidity and mortality in diabetic patients and also the leading single cause of end-stage renal disease in the United States. A large proportion of diabetic patients develop DKD and others don't, even with comparable blood glucose levels, indicating a significant genetic component of disease susceptibility. The glomerulus is the primary site of diabetic injury in the kidney, glomerular hypertrophy and podocyte depletion are glomerular hallmarks of progressive DKD, and the degree of podocyte loss correlates with severity of the disease...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29621522/metabolic-changes-in-urine-and-serum-during-progression-of-diabetic-kidney-disease-in-a-mouse-model
#18
Nan Hee Kim, Jin Seong Hyeon, Nam Hoon Kim, Ahreum Cho, Gayoung Lee, Seo Young Jang, Mi-Kyung Kim, Eun Young Lee, Choon Hee Chung, Hunjoo Ha, Geum Sook Hwang
Diabetic kidney disease (DKD) involves various pathogenic processes during progression to end stage renal disease, and activated metabolic pathways might be changing based on major pathophysiologic mechanisms as DKD progresses. In this study, nuclear magnetic resonance spectroscopy (NMR)-based metabolic profiling was performed in db/db mice to suggest potential biomarkers for early detection and its progression. We compared concentrations of serum and urinary metabolites between db/m and db/db mice at 8 or 20 weeks of age and investigated whether changes between 8 and 20 weeks in each group were significant...
May 15, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29604362/lacking-ketohexokinase-a-exacerbates-renal-injury-in-streptozotocin-induced-diabetic-mice
#19
Tomohito Doke, Takuji Ishimoto, Takahiro Hayasaki, Satsuki Ikeda, Masako Hasebe, Akiyoshi Hirayama, Tomoyoshi Soga, Noritoshi Kato, Tomoki Kosugi, Naotake Tsuboi, Miguel A Lanaspa, Richard J Johnson, Kenji Kadomatsu, Shoichi Maruyama
OBJECTIVE: Ketohexokinase (KHK), a primary enzyme in fructose metabolism, has two isoforms, namely, KHK-A and KHK-C. Previously, we reported that renal injury was reduced in streptozotocin-induced diabetic mice which lacked both isoforms. Although both isoforms express in kidney, it has not been elucidated whether each isoform plays distinct roles in the development of diabetic kidney disease (DKD). The aim of the study is to elucidate the role of KHK-A for DKD progression. MATERIALS AND METHODS: Diabetes was induced by five consecutive daily intraperitoneal injections of streptozotocin (50 mg/kg) in C57BL/6 J wild-type mice, mice lacking KHK-A alone (KHK-A KO), and mice lacking both KHK-A and KHK-C (KHK-A/C KO)...
March 28, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29602760/preventing-the-development-and-progression-of-diabetic-kidney-disease-where-do-we-stand
#20
REVIEW
Georgios Zagkotsis, Maria Markou, Eleni Paschou, Panagiota Papanikolaou, Nikos Sabanis
Diabetic kidney disease (DKD) is a major factor associated with increased cardiovascular (CV) and all-cause mortality and morbidity in patients with diabetes. Current standard therapy includes intensive management of hyperglycemia and blood pressure control with renin-angiotensin-aldosterone system (RAAS) blockers. Despite the implementation of this strategy, DKD remains the leading cause of end-stage renal disease (ESRD), mainly because of the increasing burden of diabetes mellitus. The aim of this review is to evaluate the available evidence, focusing on the benefit of current treatment in the development and progression of DKD...
March 22, 2018: Diabetes & Metabolic Syndrome
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