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https://www.readbyqxmd.com/read/28921768/microrna-326-3p-ameliorates-high-glucose-and-ox-ldl-ic-induced-fibrotic-injury-in-renal-mesangial-cells-by-targeting-fc%C3%AE-riii
#1
Yiting Wang, Rui Zhang, Junlin Zhang, Fang Liu
AIM: To identify the regulatory relationship between miR-326-3p and FcγRIII, and to explore the involvement of miR-326-3p/FcγRIII/TGF-β/Smad signaling pathway in fibrotic injury, which was induced by the high glucose (HG) and oxidized low density lipoprotein immune complex (ox-LDL-IC) in mouse glomerular mesangial cells (GMCs) METHODS: Dual-luciferase reporter system and real time PCR (RT-PCR) were used to identify FcγRIII as a target gene of miR-326-3p. Lentiviral transduction was utilized to construct different expression of miR-326-3p in GMCs, which were divided into three groups: miR-326-3p mimics group (miR-326-3p group), miR-326-3p inhibitor group (miR-326-3p-inhibit group) and scramble control group (control group)...
September 17, 2017: Nephrology
https://www.readbyqxmd.com/read/28881473/the-classic-signalling-and-trans-signalling-of-interleukin-6-are-both-injurious-in-podocyte-under-high-glucose-exposure
#2
Chun-Tao Lei, Hua Su, Chen Ye, Hui Tang, Pan Gao, Cheng Wan, Fang-Fang He, Yu-Mei Wang, Chun Zhang
Interleukin-6 (IL-6) is a multifunctional cytokine that employs IL-6 classic and trans-signalling pathways, and these two signal channels execute different or even opposite effects in certain diseases. As a cardinal event of diabetic kidney disease (DKD), whether the podocyte abnormalities are associated with IL-6 signalling, especially classic or trans-signalling respectively, remains unclear. In this study, we identified that the circulatory IL-6, soluble IL-6R (sIL-6R) and soluble glycoprotein 130 (sgp130) levels are elevated in patients with DKD...
September 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28870804/high-glucose-instigates-tubulointerstitial-injury-by-stimulating-hetero-dimerization-of-adiponectin-and-angiotensin-ii-receptors
#3
Dongqing Zha, Huaiyan Cheng, Weiwei Li, Yizhe Wu, Xiaoning Li, Lian Zhang, Ying-Hong Feng, Xiaoyan Wu
Abnormal expression and dysfunction of adiponectin and the cognate receptors are involved in diabetes and diabetic kidney disease (DKD), whereas angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) alleviate diabetic albuminuria and prevent development of DKD through upregulation of adiponectin expression. Here we report that high glucose stimulates expression of angiotensin II (AngII) receptors (AT1 and AT2) in renal proximal tubular epithelial cells (NRK-52E). These receptors underwent hetero-dimerization with adiponectin receptor AdipoR1 and AdipoR2, respectively...
September 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28855892/albuminuria-reduction-after-high-dose-of-vitamin-d-in-patients-with-type-1-diabetes-mellitus-a-pilot-study
#4
João Soares Felício, Alana Ferreira de Oliveira, Amanda Soares Peixoto, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Manuela Nascimento de Lemos, Sávio Diego Nascimento Cavalcante, Fabricio de Souza Resende, Márcia Costa Dos Santos, Ana Regina Motta, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, Karem Miléo Felício
BACKGROUND: Some studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD. METHODS: 22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient's previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28845433/urinary-neutrophil-gelatinase-associated-lipocalin-is-complementary-to-albuminuria-in-diagnosis-of-early-stage-diabetic-kidney-disease-in-type-2-diabetes
#5
Agnieszka Gala-Błądzińska, Paulina Dumnicka, Beata Kuśnierz-Cabala, Katarzyna Rybak, Ryszard Drożdż, Agnieszka Żyłka, Marek Kuźniewski
BACKGROUND: Two clinical phenotypes of diabetic kidney disease (DKD) have been reported, that is, with or without increased albuminuria. The aim of study was to assess the usefulness of urinary neutrophil gelatinase-associated lipocalin (uNGAL) for the early diagnosis of DKD in the type 2 diabetes mellitus (T2DM). METHODS: The study group consisted of 123 patients with T2DM (mean age 62 ± 14 years), with urine albumin/creatinine ratio (uACR) < 300 mg/g and eGFR ≥ 60 ml/min/1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28834119/racial-differences-in-nocturnal-dipping-status-in-diabetic-kidney-disease-results-from-the-stop-dkd-simultaneous-risk-factor-control-using-telehealth-to-slow-progression-of-diabetic-kidney-disease-study
#6
Leah L Zullig, Clarissa J Diamantidis, Hayden B Bosworth, Manjushri V Bhapkar, Huiman Barnhart, Megan M Oakes, Jane F Pendergast, Julie J Miller, Uptal D Patel
While racial variation in ambulatory blood pressure (BP) is known, patterns of diurnal dipping in the context of diabetic kidney disease have not been well defined. The authors sought to determine the association of race with nocturnal dipping status among participants with diabetic kidney disease enrolled in the STOP-DKD (Simultaneous Risk Factor Control Using Telehealth to Slow Progression of Diabetic Kidney Disease) trial. The primary outcome was nocturnal dipping-percent decrease in average systolic BP from wake to sleep-with categories defined as reverse dippers (decrease <0%), nondippers (0%-<10%), and dippers (≥10%)...
August 20, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28829977/hdl-subclasses-and-the-common-cetp-taqib-variant-predict-the-incidence-of-microangiopatic-complications-in-type-2-diabetic-women-a-9years-follow-up-study
#7
Giuseppina T Russo, Annalisa Giandalia, Elisabetta L Romeo, Marco Muscianisi, Maria Concetta Ruffo, Angela Alibrandi, Alessandra Bitto, Fiorella Forte, Andrea Grillone, Bela Asztalos, Domenico Cucinotta
AIMS: Diabetic kidney disease (DKD) and retinopathy (DR) develop in a considerable number of subjects with Type 2 Diabetes (T2D) despite the achievement of the recommended targets for glycaemia and blood pressure. Atherogenic dyslipidemia may play a relevant role, especially in T2DM women. METHODS: We report our findings on the effect of diabetic dyslipidaemia, the HDL subclasses distribution and the common cholesteryl ester transfer protein (CETP)TaqIB variant on the incidence or the progression of DKD and DR in 97 T2D women, after a ∼9years of follow-up...
July 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28822777/managing-the-course-of-diabetic-kidney-disease-from-the-old-to-the-new
#8
REVIEW
Ronald M Goldenberg, Murray Berall, Christopher T M Chan, David Z I Cherney, Julie A Lovshin, Philip A McFarlane, Peter A Senior, Subodh Verma, Jordan J Weinstein
Diabetic kidney disease (DKD) is a group of chronic kidney diseases that is associated with significant cardiovascular as well as all-cause morbidity and mortality. Although DKD is often progressive in nature, its evolution can be modified by intensive management of glycemia and blood pressure and inhibition of the renin-angiotensin-aldosterone system. This review provides an overview of how multifactorial interventions can provide renal protection and includes a discussion of the nonglycemic effects of incretin-based diabetes therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors) and sodium-glucose cotransporter-2 inhibitors within the kidney in patients with type 2 diabetes...
August 16, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28771453/nonsteroidal-mineralocorticoid-antagonists-in-diabetic-kidney-disease
#9
Farheen K Dojki, George Bakris
PURPOSE OF REVIEW: Current data highlight the pathological aspects of excess aldosterone in promoting glomerular hypertrophy, glomerulosclerosis, and proteinuria in diabetic kidney disease (DKD). The role of nonsteroidal mineralocorticoid receptor antagonists (MRAs) in DKD is being evaluated in ongoing clinical trials. RECENT FINDINGS: Recent studies demonstrate beneficial effects of adding MRAs to the treatment regimen of patients with type 2 diabetes with nephropathy...
September 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28764219/teneligliptin-in-early-diabetic-kidney-disease-an-observation-in-asian-indian-patients-with-type-2-diabetes-mellitus-in-real-life-scenario
#10
Kiran Shah
INTRODUCTION: Teneligliptin is a recently developed Dipeptidyl Peptidase 4 (DPP4) inhibitor. Teneligliptin is suitable for glycaemic control with renal impairment including end stage renal disease. AIM: To assess the efficacy and safety of teneligliptin in Asian Indian patients of Type 2 Diabetes Mellitus (T2DM) with early Diabetic Kidney Disease (DKD). MATERIALS AND METHODS: This was a single centre, retrospective analysis of patients with early DKD, who received teneligliptin 20 mg once daily for 24 weeks...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28760651/evaluation-of-urinary-autophagy-transcripts-expression-in-diabetic-kidney-disease
#11
Marwa Matboli, Ahmed E M Azazy, Seham Adel, Miram M Bekhet, Sanaa Eissa
BACKGROUND: We identified and validated novel urinary autophagy markers in diabetic kidney disease (DKD) based on bioinformatics analysis and clinical validation. PATIENTS & METHODS: We retrieved three novel autophagy genes related to DKD from public microarray databases, namely; microtubule-associated protein light chain (MAP1LC3A), WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2), and RB1-Inducible Coiled-Coil 1 (RB1CC1). Secondly we assessed the expression of the chosen autophagy transcript in urine sediment of 86 patients with DKD and 74 (age and sex matched) controls by reverse transcription quantitative real-time PCR...
October 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28758978/dietary-approaches-in-the-management-of-diabetic-patients-with-kidney-disease
#12
REVIEW
Gang Jee Ko, Kamyar Kalantar-Zadeh, Jordi Goldstein-Fuchs, Connie M Rhee
Chronic kidney disease (CKD) is one of the most prevalent complications of diabetes, and patients with diabetic kidney disease (DKD) have a substantially higher risk of cardiovascular disease and death compared to their non-diabetic CKD counterparts. In addition to pharmacologic management strategies, nutritional and dietary interventions in DKD are an essential aspect of management with the potential for ameliorating kidney function decline and preventing the development of other end-organ complications. Among DKD patients with non-dialysis dependent CKD, expert panels recommend lower dietary protein intake of 0...
July 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28724797/increasing-the-level-of-peroxisome-proliferator-activated-receptor-%C3%AE-coactivator-1%C3%AE-in-podocytes-results-in-collapsing-glomerulopathy
#13
Szu-Yuan Li, Jihwan Park, Chengxiang Qiu, Seung Hyeok Han, Matthew B Palmer, Zoltan Arany, Katalin Susztak
Inherited and acquired mitochondrial defects have been associated with podocyte dysfunction and chronic kidney disease (CKD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) is one of the main transcriptional regulators of mitochondrial biogenesis and function. We hypothesized that increasing PGC1α expression in podocytes could protect from CKD. We found that PGC1α and mitochondrial transcript levels are lower in podocytes of patients and mouse models with diabetic kidney disease (DKD)...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28721497/normoalbuminuric-diabetic-kidney-disease
#14
REVIEW
Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun
Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD). Early diagnosis is very important in preventing the development of DKD. Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD, and microalbuminuria has been recommended as the first clinical sign of DKD. The natural history of DKD has been divided into three stages: normoalbuminuria, microalbuminuria, and macroalbuminuria...
September 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28720285/ultrasound-based-shear-wave-elastography-in-the-assessment-of-patients-with-diabetic-kidney-disease
#15
Flaviu Bob, Iulia Grosu, Ioan Sporea, Simona Bota, Alina Popescu, Alexandra Sima, Roxana Şirli, Ligia Petrica, Romulus Timar, Adalbert Schiller
In previous studies of acoustic radiation force impulse (ARFI) elastography, using Virtual Touch tissue quantification (VTQ) (Siemens Acuson S2000), it was reported that the measurement of renal shear wave speed in patients with chronic kidney disease (CKD) is not influenced exclusively by renal fibrosis. The purpose of the present study was to analyze the role of VTQ in patients with diabetic kidney disease, considered the main cause of CKD. The study group included 164 patients: 80 patients with diabetic kidney disease (DKD) and 84 without renal disease or diabetes mellitus...
July 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28713836/increased-serum-uric-acid-level-is-a-risk-factor-for-left-ventricular-hypertrophy-but-not-independent-of-egfr-in-patients-with-type-2-diabetic-kidney-disease
#16
Chuchu Zeng, Dongsheng Cheng, Xiaohua Sheng, Guihua Jian, Ying Fan, Yuqiang Chen, Junhui Li, Hongda Bao, Niansong Wang
BACKGROUND: Although the relation between serum uric acid (SUA) and left ventricular hypertrophy (LVH) has been studied for decades, however, their association remains debatable. METHODS: This is a retrospective study in which a total of 435 hospitalized Chinese patients with type 2 DKD were enrolled. The subjects were stratified into quartiles according to SUA level. LVH was assessed by two-dimensional guided M-mode echocardiography. RESULTS: There was a significant increase in the prevalence of LVH in patients with type 2 DKD across SUA quartiles (28...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28713834/renoprotective-effect-of-the-shen-yan-fang-shuai-formula-by-inhibiting-tnf-%C3%AE-nf-%C3%AE%C2%BAb-signaling-pathway-in-diabetic-rats
#17
Jie Lv, Zhen Wang, Ying Wang, Weiwei Sun, Jingwei Zhou, Mengdi Wang, Wei Jing Liu, Yaoxian Wang
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and satisfactory therapeutic strategies have not yet been established. The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional Chinese formula composed of Astragali radix, Radixangelicae sinensis, Rheum officinale Baill, and four other herbs. It has been widely used as an effective treatment for DKD patients in China. However, little is known about the molecular mechanisms underlying SYFSF's renoprotection. In this study, we compared the protective effect of SYFSF to irbesartan on the histology and renal cells in type 2 DKD rat model and high-glucose (HG) cultured mesangial cells, respectively...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28704915/treatment-of-diabetic-kidney-disease-current-and-future-targets
#18
REVIEW
Mi-Kyung Kim
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease in Korea and worldwide, and is a risk factor for the development of cardiovascular complications. The conventional treatments for DKD are control of blood glucose and blood pressure levels by inhibiting the renin-angiotensin system. However, the prevalence of DKD continues to increase and additional therapies are required to prevent or ameliorate the condition. Many drugs have been, or are being, developed to target the molecular mechanisms in play in DKD...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28701152/performance-of-urinary-neutrophil-gelatinase-associated-lipocalin-clusterin-and-cystatin-c-in-predicting-diabetic-kidney-disease-and-diabetic-microalbuminuria-a-consecutive-cohort-study
#19
Xian-Fei Zeng, Dong-Xue Lu, Jun-Min Li, Yun Tan, Zhuo Li, Lei Zhou, Zeng-Qian Xi, Shu-Miao Zhang, Wei Duan
BACKGROUND: Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urinary neutrophil gelatinase-associated lipocalin [NGAL], clusterin, and cystatin C) for DKD and diabetic microalbuminuria, and whether or not the tubular biomarkers appear earlier than microalbuminuria. METHODS: In this consecutive cohort study, 146 type 2 diabetes mellitus (T2DM) patients with a disease duration of ≥6 years were enrolled...
July 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28695984/triptolide-prevents-extracellular-matrix-accumulation-in-experimental-diabetic-kidney-disease-by-targeting-microrna-137-notch1-pathway
#20
Fei Han, Shanshan Wang, Yunpeng Chang, Chunjun Li, Juhong Yang, Zhe Han, Baocheng Chang, Bei Sun, Liming Chen
MicroRNAs (miRNAs) are involved in multiple biological functions via suppressing target genes. Triptolide is a monomeric compound isolated from a traditional Chinese herb, which exerts protective roles in many kinds of glomerular diseases. However, our understanding of the triptolide effect on miRNAome is still limited. In this study, we found that triptolide significantly decreased albuminuria and improved glomerulosclerosis in rats with diabetic kidney disease (DKD). And triptolide also inhibited extracellular matrix (ECM) protein accumulation and the notch1 pathway activation under diabetic conditions...
July 11, 2017: Journal of Cellular Physiology
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