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https://www.readbyqxmd.com/read/27933715/efficacy-of-self-monitoring-of-blood-glucose-versus-retrospective-continuous-glucose-monitoring-in-improving-glycaemic-control-in-diabetic-kidney-disease-patients
#1
Ester Chai Kheng Yeoh, Boon Khim Lim, Sharon Fun, Julia Tong, Lee Ying Yeoh, Chee Fang Sum, Tavintharan Subramaniam, Su Chi Lim
AIMS: Patients with diabetic kidney disease (DKD) on anti-diabetic agents, are at greater risk of glycemic variations, both hypoglycemia and hyperglycemia. We aimed to compare glycemic control (using HbA1c) and hypoglycemia incidence in patients with Stage 3 DKD (eGFR 30-60 ml/min/1.73 m(2) ), receiving retrospective CGM-guided anti-diabetic therapy versus self-monitoring of blood glucose (SMBG) over 3 months. METHODS: Thirty patients with HbA1c > 8% were randomized to 6-day retrospective CGM or SMBG...
December 9, 2016: Nephrology
https://www.readbyqxmd.com/read/27920542/protective-effect-of-tartary-buckwheat-on-renal-function-in-type-2-diabetics-a-randomized-controlled-trial
#2
Ju Qiu, Zaigui Li, Yuchang Qin, Yanfen Yue, Yanping Liu
Tartary buckwheat (TB) has been reported to be associated with a decreased risk of type 2 diabetes mellitus (T2DM), and T2DM has had a major impact on the development of diabetic kidney disease (DKD). Thus, the hypothesis that a daily intake of TB will improve DKD risk factors, including urinary albumin to creatinine ratio (UACR), urea nitrogen (UN), serum creatinine, and uric acid was tested. In a parallel, randomized, open-label controlled trial, 104 T2DM patients were randomly assigned to a diet control group (systematic diet plans and intensive nutritional education) or a TB intervention group (daily replacement of a portion of staple foods with TB foods)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27900954/renin-angiotensin-aldosterone-system-blockade-in-diabetic-kidney-disease-a-critical-and-contrarian-point-of-view
#3
REVIEW
Mohamed E Elrggal, Shaaban M S Ahmed, Meguid El Nahas
Diabetes mellitus is the most common cause of end-stage renal disease (ESRD) worldwide. Diabetic kidney disease (DKD) is associated with high morbidity and cardiovascular mortality. A number of guidelines and recommendations have been issued over the years recommending the use of renin-angiotensin-aldosterone system (RAAS) blockade in the management of DKD. This critical analysis takes a contrarian view, based on a selection of key clinical trials in the field, to argue that albuminuria should not be considered a target for treatment but instead a surrogate marker of DKD progression...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899487/glomerular-endothelial-mitochondrial-dysfunction-is-essential-and-characteristic-of-diabetic-kidney-disease-susceptibility
#4
Ilse Daehn, Haiying Qi, Gabriella Casalena, Shaolin Shi, Liping Yu, Kerstin Ebefors, Yezhou Sun, Weijia Zhang, Vivette D'Agati, Detlef Schlondorff, Börje Haraldsson, Erwin Böttinger
The molecular signaling mechanisms between glomerular cell types during initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We compared the early transcriptome profile between DKD resistant C57BL/6J (B6) and DKD susceptible DBA/2J (D2) glomeruli, and demonstrated a significant down regulation of essential mitochondrial genes in glomeruli from diabetic D2 mice, but not in B6 with comparable hyperglycemia. Diabetic D2 mice manifested increased mtDNA lesions (8-oxoG), exclusively localized to glomerular endothelial cells after 3 weeks of diabetes and these accumulated over time as well as increased urine secretion of 8-oxodG...
November 29, 2016: Diabetes
https://www.readbyqxmd.com/read/27876428/dmp-1-attenuates-oxidative-stress-and-inhibits-tgf-%C3%AE-activation-in-rats-with-diabetic-kidney-disease
#5
Na Du, Shunan Liu, Chongshuang Cui, Mo Zhang, Jibin Jia, Xia Cao
INTRODUCTION: DMP-1 supplement has a satisfactory effect on diabetic kidney disease in patients with whether T1DM or T2DM. Oxidative stress and TGF-β signal pathway activation are essential in the pathogenesis of DKD. We aim to investigate the effect of DMP-1 on oxidative stress and TGF-β activation in rats with DKD. MATERIALS AND METHODS: Male Wistar rats were enrolled and randomly allocated into five groups: Control group, STZ group (60 mg/kg, ip), DMP-1 low dose group (0...
November 23, 2016: Renal Failure
https://www.readbyqxmd.com/read/27867882/prevalence-of-hypothyroidism-in-diabetic-kidney-disease-and-effect-of-thyroid-hormone-replacement-on-estimate-glomerular-filtration-rate
#6
Sarita Bajaj, Naincy Purwar, Arvind Gupta, Poonam Gupta, Anubha Srivastava
AIMS: To determine the prevalence of subclinical and overt hypothyroidism in diabetic kidney disease (DKD) and effect of thyroid hormone replacement on progression of DKD. MATERIALS AND METHODS: A prospective cohort study on 41 adult DKD patients who were screened for hypothyroidism. Hypothyroid DKD patients were started on levothyroxine replacement and were reviewed after 3 and 6 months. RESULTS: Of the total population, 14 (34.1%) cases were hypothyroid, among whom 12 (29...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27853373/shear-wave-elastography-imaging-for-assessing-the-chronic-pathologic-changes-in-advanced-diabetic-kidney-disease
#7
Kamal Hassan, Norman Loberant, Nur Abbas, Hassan Fadi, Hassan Shadia, Khaled Khazim
OBJECTIVE: The assessment of the grade of renal fibrosis in diabetic kidney disease (DKD) requires renal biopsy, which may be associated with certain risks. To assess the severity of chronic pathologic changes in DKD, we performed a quantitative analysis of renal parenchymal stiffness in advanced DKD, using shear wave elastography (SWE) imaging. PATIENTS AND METHODS: Twenty-nine diabetic patients with chronic kidney disease (CKD) grades 3-4 due to DKD, and 23 healthy subjects were enrolled...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27829988/targeting-gut-microbiota-a-potential-promising-therapy-for-diabetic-kidney-disease
#8
REVIEW
Zhonge Chen, Shuishan Zhu, Gaosi Xu
Conventional studies reveal a contributory role of gut microbiota in the process of diabetes mellitus (DM) and end-stage renal disease (ESRD). However, the mechanism through which gut microbiota influence diabetic kidney disease (DKD) is ignored. In the present article, we reviewed the changes in gut microbiota of patients with DM, DKD as well as ESRD, and how this may contribute to the progression of DKD. Although further studies are needed to either selectively change the composition of the gut microbiota or to pharmacologically control the metabolites of microbiota, the gut microbiota represents a new potential therapeutic target for DKD...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27784780/exendin-4-ameliorates-lipotoxicity-induced-glomerular-endothelial-cell-injury-by-improving-abc-transporter-a1-mediated-cholesterol-efflux-in-diabetic-apoe-knockout-mice
#9
Qing-Hua Yin, Rui Zhang, Li Li, Yi-Ting Wang, Jing-Ping Liu, Jie Zhang, Lin Bai, Jing-Qiu Cheng, Ping Fu, Fang Liu
The ATP-binding cassette transporter A1 (ABCA1), which promotes cholesterol efflux from cells and inhibits inflammatory responses, is highly expressed in the kidney. Research has shown that exendin-4, a glucagon-like peptide-1 receptor (GLP-1R) agonist, promotes ABCA1 expression in multiple tissues and organs; however, the mechanisms underlying exendin-4 induction of ABCA1 expression in glomerular endothelial cells are not fully understood. In this study we investigated the effect of exendin-4 on ABCA1 in glomerular endothelial cells of diabetic kidney disease (DKD) and the possible mechanism...
October 26, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27776152/serum-and-urinary-progranulin-in-diabetic-kidney-disease
#10
Bruna Bellincanta Nicoletto, Thaiana Cirino Krolikowski, Daisy Crispim, Luis Henrique Canani
Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and increased progranulin levels. We aimed to better describe the relationship between serum and urinary progranulin levels and DKD in T2DM. This is a case-control study including four groups of subjects: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1...
2016: PloS One
https://www.readbyqxmd.com/read/27766790/risk-factors-for-the-development-and-progression-of-diabetic-kidney-disease-in-patients-with-type-2-diabetes-mellitus-and-advanced-diabetic-retinopathy
#11
Kyung Jin Yun, Hye Ji Kim, Mee Kyoung Kim, Hyuk Sang Kwon, Ki Hyun Baek, Young Jung Roh, Ki Ho Song
BACKGROUND: Some patients with type 2 diabetes mellitus (T2DM) do not develop diabetic kidney disease (DKD) despite the presence of advanced diabetic retinopathy (DR). We aimed to investigate the presence of DKD and its risk factors in patients with T2DM and advanced DR. METHODS: We conducted a cross-sectional study in 317 patients with T2DM and advanced DR. The phenotypes of DKD were divided into three groups according to the urine albumin/creatinine ratio (uACR, mg/g) and estimated glomerular filtration rate (eGFR, mL/min/1...
September 20, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27721376/diabetic-nephropathy-the-genetic-architecture-of-dkd-in-t1dm
#12
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27703024/plasma-triglycerides-and-hdl-c-levels-predict-the-development-of-diabetic-kidney-disease-in-subjects-with-type-2-diabetes-the-amd-annals-initiative
#13
Giuseppina T Russo, Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Antonio Ceriello, Stefano Genovese, Pietro Guida, Carlo Giorda, Domenico Cucinotta, Roberto Pontremoli, Paola Fioretto
OBJECTIVE: Despite the achievement of blood glucose, blood pressure, and LDL-cholesterol (LDL-C) targets, the risk for diabetic kidney disease (DKD) remains high among patients with type 2 diabetes. This observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL-cholesterol (HDL-C) levels-contributes to this high residual risk for DKD. RESEARCH DESIGN AND METHODS: Among a total of 47,177 patients attending Italian diabetes centers, 15,362 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1...
October 4, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27701367/current-management-of-diabetic-patients-with-kidney-disease-a-renal-cardio-endocrine-perspective
#14
Roberto Pecoits-Filho
Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients. DKD results in increased hospitalizations and mortality rates, especially due to cardiovascular complications. This high burden of kidney disease is mainly due to the increasing complexity of in- outpatient care for patients with DM. There is a strikingly complex interaction of kidney dysfunction with many aspects of diabetes care, such as redefinition of targets of treatment, interactions of traditional and non-traditional risk factors, and pharmacological issues related to pharmacokinetic and side effects of drugs ...
October 4, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27698952/epigallocatechin-3-gallate-attenuates-renal-damage-by-suppressing-oxidative-stress-in-diabetic-db-db-mice
#15
Xiu Hong Yang, Yu Pan, Xiao Li Zhan, Bao Long Zhang, Li Li Guo, Hui Min Jin
Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity. In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells. EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II. Moreover, EGCG could also change the level of several parameters associated with oxidative stress. In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27638852/the-association-of-ace-gene-polymorphism-with-diabetic-kidney-disease-and-renoprotective-efficacy-of-valsartan
#16
Yuying Wang, Wen Peng, Xiaoxue Zhang, Huibo Qiao, Li Wang, Zhigang Xu, Chenguang Wu
INTRODUCTION: To investigate the associations between the insertion/deletion (I/D) polymorphisms in the angiotensin converting enzyme (ACE) gene and susceptibility to diabetic kidney disease (DKD); and the efficacy of valsartan in reducing the urine protein in Type 2 diabetes mellitus (T2DM) patients. MATERIALS AND METHODS: We enrolled 128 T2DM patients in this study, including 54 cases with DKD (DKD+) and 74 controls (DKD-). The ACE polymorphism was assayed by polymerase chain reaction (PCR), and the genotype distribution and allele frequency were analyzed...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27625045/dipeptidyl-peptidase-4-activity-is-associated-with-urine-albumin-excretion-in-type-1-diabetes
#17
Lea Duvnjak, Matea Nikolac Perković, Kristina Blaslov
AIMS: The inability of kidneys to prevent urinary protein leakage represents the earliest sign of renal damage in diabetic kidney disease (DKD). Recent data suggest the possible nephroprotective role of the dipeptidyl peptidase-4 (DPP-4) inhibitors. We aimed to investigate whether serum DPP-4 activity is associated with urine albumin excretion (UAE) in patients with type 1 diabetes (type 1 DM). METHODS: DPP-4 activity and UAE measurement were performed in 113 patients with type 1 DM and glomerular filtration rate (GFR) within normal range...
August 28, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27605583/the-gomez-equations-and-renal-hemodynamic-function-in-kidney-disease-research
#18
Petter Bjornstad, Marko Škrtić, Yuliya Lytvyn, David M Maahs, Richard J Johnson, David Z I Cherney
Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease. A major challenge in preventing DKD is the difficulty in identifying high-risk patients at an early, pre-clinical stage. Albuminuria and eGFR as measures of renal function in DKD research and clinical practice are limited by regression of one-third of patients with microalbuminuria to normoalbuminuria and eGFR is biased and imprecise in the normal-elevated range. Moreover, existing methods that are used to assess renal function do not give detailed insight into the location of the renal hemodynamic effects of pharmacological agents at the segmental level...
September 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27579698/mouse-models-of-diabetes-obesity-and-related-kidney-disease
#19
Sarah J Glastras, Hui Chen, Rachel Teh, Rachel T McGrath, Jason Chen, Carol A Pollock, Muh Geot Wong, Sonia Saad
Multiple rodent models have been used to study diabetic kidney disease (DKD). The purpose of the present study was to compare models of diabetes and obesity-induced metabolic syndrome and determine differences in renal outcomes. C57BL/6 male mice were fed either normal chow or high fat diet (HFD). At postnatal week 8, chow-fed mice were randomly assigned to low-dose streptozotocin (STZ, 55 mg/kg/day, five consecutive days) or vehicle control, whereas HFD-fed mice were given either one high-dose of STZ (100 mg/kg) or vehicle control...
2016: PloS One
https://www.readbyqxmd.com/read/27558558/immunity-and-inflammation-in-diabetic-kidney-disease-translating-mechanisms-to-biomarkers-and-treatment-targets
#20
Raimund Pichler, Maryam Afkarian, Brad P Dieter, Katherine R Tuttle
Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite current pharmacological treatments, including strategies for optimizing glycemic control and inhibitors of the renin-angiotensin system, DKD still makes up almost half of all cases of end-stage renal disease in the United States. Compelling and mounting evidence has clearly demonstrated that immunity and inflammation play a paramount role in the pathogenesis of DKD...
August 24, 2016: American Journal of Physiology. Renal Physiology
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