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JOURNAL ARTICLE
Joseph Sartini, Michael Fang, Mary R Rooney, Elizabeth Selvin, Josef Coresh, Scott Zeger
BACKGROUND: Standard continuous glucose monitoring (CGM) metrics: mean glucose, standard deviation, coefficient of variation, and time in range, fail to capture the shape of variability in the CGM time series. This information could facilitate improved diabetes management. METHODS: We analyzed CGM data from 141 adults with type 2 diabetes in the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial. Participants in HYPNOS wore CGM sensors for up to two weeks at two time points, three months apart...
April 20, 2024: Journal of Diabetes Science and Technology
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JOURNAL ARTICLE
Zhang Xia, Xuechun Luo, Yanzhi Wang, Tingling Xu, Jianqun Dong, Wei Jiang, Yingying Jiang
OBJECTIVE: To understand the awareness and practice of diabetic kidney disease (DKD) or nephropathy screening among community-based patients with type 2 diabetes in six provinces and cities in China, and to analyse the related factors affecting screening practices. METHODS: From December 2021 to March 2022, a cross-sectional survey was conducted using a structured questionnaire in 6230 patients with type 2 diabetes aged 18 years and older. The content of the questionnaire includes three parts: the general situation of diabetic patients (gender, age, ethnicity, marriage, education, occupation, etc...
April 19, 2024: BMC Health Services Research
#23
JOURNAL ARTICLE
Ammar Abdulrahman Jairoun, Chong Chee Ping, Baharudin Ibrahim
Predicting the course of kidney disease in individuals with both type 1 and type 2 diabetes mellitus (DM) is a significant clinical and policy challenge. In several regions, DM is now the leading cause of end-stage renal disease. The aim of this study to identify both modifiable and non-modifiable risk factors, along with clinical markers and coexisting conditions, that increase the likelihood of stage 3-5 chronic kidney disease (CKD) development in individuals with type 2 DM in the United Arab Emirates (UAE)...
April 19, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Daniel Edmonston, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Zachary Lampron, Christina Shay, Keith Marsolo, W Schuyler Jones, Javed Butler, Raj C Shah, Alanna M Chamberlain, Daniel E Ford, Howard S Gordon, Wenke Hwang, Alexander Chang, Ajaykumar Rao, Hayden B Bosworth, Neha Pagidipati
Placebo-controlled trials of sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate kidney and cardiovascular benefits for people with type 2 diabetes (T2D) and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4i), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare outcomes for empagliflozin and DPP4i initiators with T2D between 2016 and 2020...
April 17, 2024: American Journal of Cardiology
#25
REVIEW
Jared Gabriel L Dela Rosa, Charlene Divine M Catral, Nico Alexander Reyes, Danna Mae S Opiso, Erika P Ong, Eric David B Ornos, Jerico R Santos, Elgin Paul B Quebral, Maria Llaine J Callanta, Raymond V Oliva, Ourlad Alzeus G Tantengco
AIMS: In this paper, we discuss the existing data on the burden of hypertension in the Philippines and present the status of management, prevention, and control of hypertension in the country. METHODS: A literature review was conducted to synthesize the status of hypertension care in the Philippines. RESULTS: Hypertension continues to contribute to the country's leading causes of death. Similar to the global trend, almost half of hypertensive Filipinos are still not aware of their condition, and only 27 % have it under control...
April 16, 2024: Diabetes & Metabolic Syndrome
#26
JOURNAL ARTICLE
Chang Hyun Doh, Ye-Jee Kim, Jae Kwang Kim, Jongjin Lee, Young Ho Shin
Several studies have revealed the risk factors for carpal tunnel syndrome (CTS). However, no studies have evaluated the influence of these risk factors on the selection of treatment modalities for CTS. This study aimed to determine the influence of CTS risk factors on the selection of CTS treatment modalities with a focus on corticosteroid injection (CI) and surgery. We conducted a retrospective cohort study of patients aged ≥20 years with newly diagnosed CTS in the Korean health insurance review and assessment service between 2010 and 2019...
April 19, 2024: Medicine (Baltimore)
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REVIEW
Tyler Drake, Adrienne Landsteiner, Lisa Langsetmo, Roderick MacDonald, Maylen Anthony, Caleb Kalinowski, Kristen Ullman, Charles J Billington, Anjum Kaka, Shahnaz Sultan, Timothy J Wilt
BACKGROUND: Newer diabetes medications may have beneficial effects on mortality, cardiovascular outcomes, and renal outcomes. PURPOSE: To evaluate the effectiveness, comparative effectiveness, and harms of sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP1) agonists, dipeptidyl peptidase-4 (DPP4) inhibitors, and long-acting insulins as monotherapy or combination therapy in adults with type 2 diabetes mellitus (T2DM). DATA SOURCES: MEDLINE and EMBASE for randomized controlled trials (RCTs) published from 2010 through January 2023...
April 19, 2024: Annals of Internal Medicine
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JOURNAL ARTICLE
Amir Qaseem, Adam J Obley, Tatyana Shamliyan, Lauri A Hicks, Curtis S Harrod, Carolyn J Crandall
DESCRIPTION: The American College of Physicians (ACP) developed this clinical guideline to update recommendations on newer pharmacologic treatments of type 2 diabetes. This clinical guideline is based on the best available evidence for effectiveness, comparative benefits and harms, consideration of patients' values and preferences, and costs. METHODS: This clinical guideline is based on a systematic review of the effectiveness and harms of newer pharmacologic treatments of type 2 diabetes, including glucagon-like peptide-1 (GLP-1) agonists, a GLP-1 agonist and glucose-dependent insulinotropic polypeptide agonist, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, and long-acting insulins, used either as monotherapy or in combination with other medications...
April 19, 2024: Annals of Internal Medicine
#29
JOURNAL ARTICLE
Hanjin Park, Daehoon Kim, Seng Chan You, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Dong-Min Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Pil-Sung Yang, Boyoung Joung
BACKGROUND: A study was designed to investigate whether the coronary artery disease polygenic risk score (CAD-PRS) may guide lipid-lowering treatment initiation as well as deferral in primary prevention beyond established clinical risk scores. METHODS AND RESULTS: Participants were 311 799 individuals from the UK Biobank free of atherosclerotic cardiovascular disease, diabetes, chronic kidney disease, and lipid-lowering treatment at baseline. Participants were categorized as statin indicated, statin indication unclear, or statin not indicated as defined by the European and US guidelines on statin use...
April 19, 2024: Journal of the American Heart Association
#30
REVIEW
Xingjing Liu, Haonan Qin, Yuanyuan Liu, Jingjing Ma, Yiming Li, Yu He, Huimin Zhu, Li Mao
BACKGROUND: As a scaffold protein, calcium/calmodulin-dependent serine protein kinase (CASK) has been extensively studied in a variety of tissues throughout the body. The Cask gene is ubiquitous in several tissues, such as the neurons, islets, heart, kidneys and sperm, and is mostly localised in the cytoplasm adjacent to the basement membrane. CASK binds to a variety of proteins through its domains to exerting its biological activity. SCOPE OF REVIEW: Here, we discuss the role of CASK in multiple tissues throughout the body...
April 30, 2024: Heliyon
#31
JOURNAL ARTICLE
Yechan Han, Dae-Yeon Kim, Jiyoung Woo, Jaeyun Kim
Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, posing significant health risks such as cardiovascular disease, and nerve, kidney, and eye damage. Effective management of blood glucose is essential for individuals with diabetes to mitigate these risks. This study introduces the Glu-Ensemble, a deep learning framework designed for precise blood glucose forecasting in patients with type 2 diabetes. Unlike other predictive models, Glu-Ensemble addresses challenges related to small sample sizes, data quality issues, reliance on strict statistical assumptions, and the complexity of models...
April 30, 2024: Heliyon
#32
Wei Lu, Lin Kuang, Yuxing Hu, Jialing Shi, Qi Li, Wen Tian
INTRODUCTION: Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease comprising five stages: fever, hypotension, oliguria, diuresis (polyuria), and convalescence. Increased vascular permeability, coagulopathy, and renal injury are typical clinical features of HFRS, which has a case fatality rate of 1-15%. Despite this, a comprehensive meta-analyses of the clinical characteristics of patients who died from HFRS is lacking. METHODS: Eleven Chinese- and English-language research databases were searched, including the China National Knowledge Infrastructure Database, Wanfang Database, SinoMed, VIP Database, PubMed, Embase, Scopus, Cochrane Library, Web of Science, Proquest, and Ovid, up to October 5, 2023...
2024: Frontiers in Microbiology
#33
JOURNAL ARTICLE
James Zhang, Florence Bradshaw, Michal Duchniewicz, Fernanda W Fernandes, Rahul Geetala, Matjia Krkovic
Introduction Understanding the different opioid pain relief requirements between patients with upper limb fractures can be useful in forming specific evidence-based guidelines and balancing patient-clinician prescribing discussions with opioid stewardship. We investigated the predictors for opioid requirements in upper limb fractures. Methods We retrospectively investigated all upper limb fractures from the shoulder to the wrist treated at a major trauma center from January 2015 to January 2022. The data collected consisted of fracture location, demographics, comorbidities, and management options...
March 2024: Curēus
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JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#35
REVIEW
Imelda Cabalar, Thu H Le, Abigail Silber, Matthew O'Hara, Bilal Abdallah, Monisha Parikh, Robert Busch
Blood tests are vital to prevention, diagnosis, and management of chronic diseases. Despite this, it can be challenging to construct a comprehensive view of the clinical importance of blood testing because relevant literature is typically fragmented across different disease areas and patient populations. This lack of collated evidence can also make it difficult for primary care providers to adhere to best practices for blood testing across different diseases and guidelines. Thus, this review article synthesizes the recommendations for, and importance of, blood testing across several common chronic conditions encountered in primary care and internal medicine, including cardiovascular diseases, diabetes mellitus, chronic kidney disease, vitamin D deficiency, iron deficiency, and rheumatoid arthritis...
April 16, 2024: American Journal of the Medical Sciences
#36
JOURNAL ARTICLE
Nour Asfour, Kevin C Zhang, Jessica Lu, Peter P Reese, Milda Saunders, Monica Peek, Molly White, Govind Persad, William F Parker
RATIONALE & OBJECTIVE: The US Kidney Allocation System (KAS) prioritizes candidates with ≤20% Estimated Post-Transplant Survival (EPTS) for high longevity kidneys defined by a ≤20% Kidney Donor Profile Index (KDPI). Use of EPTS in the KAS deprioritizes candidates with older age, diabetes, and longer dialysis durations. We assessed whether this use also disadvantages racial-ethnic minority candidates, who are younger but more likely to have diabetes and longer durations of kidney failure requiring dialysis...
April 16, 2024: American Journal of Kidney Diseases
#37
JOURNAL ARTICLE
Wanting Weng, Siow-Yi Wong, Gary Yee Ang, Sheryl Hui Xian Ng, Chee Kong Lim, See Cheng Yeo
Background Accurate identification of individuals at risk of developing chronic kidney disease (CKD) may improve clinical care. Nelson et al developed prediction equations to estimate the risk of incident eGFR of less than 60 ml/min/1.73m2 in diabetic and non-diabetes patients using data from 34 multinational cohorts. We aim to validate the non-diabetes equation in our local multi-ethnic cohort and develop further prediction models. Methods Demographics, clinical and laboratory data of hypertensive non-diabetes patients with baseline eGFR ≥60ml/min/1...
April 18, 2024: Nephron
#38
JOURNAL ARTICLE
Malte M Tetens, Lars Haukali Omland, Ram B Dessau, Svend Ellermann-Eriksen, Nanna S Andersen, Charlotte Sværke Jørgensen, Christian Østergaard, Jacob Bodilsen, Kirstine K Søgaard, Jette Bangsborg, Alex Christian Yde Nielsen, Jens Kjølseth Møller, Ming Chen, Jesper Hastrup Svendsen, Niels Obel, Anne-Mette Lebech
BACKGROUND: Lyme borreliosis is a tick-borne disease caused by the bacterium Borrelia burgdorferi (Bb) sensu lato complex. Previous studies have suggested an association between Lyme borreliosis and heart failure, which have been suggested to be a possible manifestation of Lyme carditis. We aimed to investigate the risk of heart failure among individuals tested for serum Bb antibodies, and serum Bb seropositive individuals. METHODS: We performed a matched nationwide cohort study (Denmark, 1993-2020) and included 52,200 Bb seropositive individuals, and two age- and sex-matched comparison cohorts: 1) 104,400 Bb seronegative comparison cohort members, and 2) 261,000 population controls...
April 17, 2024: Ticks and Tick-borne Diseases
#39
JOURNAL ARTICLE
Yusuf Urade, Zaheera Cassimjee, Chandni Dayal, Sheetal Chiba, Adekunle Ajayi, Malcolm Davies
Chronic kidney disease (CKD) is a significant contributor to the global burden of non-communicable disease. Early intervention may facilitate slowing down of progression of CKD; recognition of at-risk patient groups may improve detection through screening. We retrospectively reviewed the clinical records of 960 patients attending a specialist nephrology outpatient clinic during the period 1 January 2011-31 December 2021. A significant proportion (47.8%) of patients were referred with established CKD stage G4 or G5...
2024: PLOS Glob Public Health
#40
Sebastiano A G Lava, Craig Laurence, Alessandro Di Deo, Nicole Sekarski, Michael Burch, Oscar Della Pasqua
INTRODUCTION: In adults, sodium-glucose cotransporter type 2 inhibitors have revolutionised the treatment of type 2 diabetes mellitus, heart failure, and chronic kidney disease. OBJECTIVE: We aimed to review information on compassionate use, clinical pharmacology, efficacy, and safety of dapagliflozin and empagliflozin in children. METHODS: We conducted a systematic review of published clinical trials, case reports, and observational studies in Medline, Excerpta Medica, and Web of Science databases from inception to September 2023...
April 18, 2024: Paediatric Drugs
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