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Diabetic kidney disease

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https://www.readbyqxmd.com/read/29160954/islet-allo-autotransplantation-allogeneic-pancreas-transplantation-followed-by-transplant-pancreatectomy-and-islet-transplantation
#1
M F Nijhoff, J Dubbeld, A R van Erkel, P J M van der Boog, T J Rabelink, M A Engelse, E J P de Koning
Simultaneous pancreas/kidney (SPK) transplantation is an important treatment option for patients with type 1 diabetes (T1D) and end stage renal disease (ESRD). Due to complications, in up to 10% of cases allograft pancreatectomy is necessary shortly after transplantation. Usually the donor pancreas is discarded. Here we report on a novel procedure to rescue endocrine tissue after allograft pancreatectomy. A 39-year-old woman with T1D and ESRD who had received an SPK transplantation required emergency allograft pancreatectomy due to bleeding at the vascular anastomosis...
November 21, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29159528/death-with-graft-function-after-kidney-transplantation-a-single-center-experience
#2
Mi-Yeon Yu, Yong Chul Kim, Jung Pyo Lee, Hajeong Lee, Yon Su Kim
BACKGROUND: Death with graft function (DWGF) is an important cause of long-term loss of grafts and patients. In this study, we investigated clinical characteristics and causes of DWGF in kidney transplant recipients. METHODS: We recruited kidney allograft recipients who underwent surgery during 1973-2016 at Seoul National University Hospital in Korea (n = 2137). We divided recipients into four groups: alive with graft function (AWGF), alive with graft loss (AWGL), DWGF, and death with graft loss (DWGL)...
November 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29159526/cardiovascular-disease-in-kidney-transplant-recipients-japan-academic-consortium-of-kidney-transplantation-jack-cohort-study
#3
Masayoshi Okumi, Yoichi Kakuta, Kohei Unagami, Ryoichi Maenosono, Katsunori Miyake, Junpei Iizuka, Toshio Takagi, Hideki Ishida, Kazunari Tanabe
BACKGROUND: The number of kidney transplant recipients (KTRs) from diabetic nephropathy (DN) and with cardiovascular disease (CVD) history has increased worldwide. Nevertheless, epidemiologic evidence of CVD in KTRs remains limited. METHODS: We investigated post-transplant CVD in 1614 adult KTRs between 1990 and 2014. CVD was defined according to the international classification of diseases (ICD-10). All-cause mortality was also investigated. Final follow-up was performed in March 2016...
November 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29159457/ertugliflozin-in-patients-with-stage-3-chronic-kidney-disease-and-type-2-diabetes-mellitus-the-vertis-renal-randomized-study
#4
George Grunberger, Sarah Camp, Jeremy Johnson, Susan Huyck, Steven G Terra, James P Mancuso, Zhi Wei Jiang, Gregory Golm, Samuel S Engel, Brett Lauring
INTRODUCTION: Ertugliflozin is a sodium-glucose cotransporter 2 inhibitor in development for type 2 diabetes mellitus (T2DM). The safety and efficacy of ertugliflozin were evaluated over 52 weeks in patients with chronic kidney disease (CKD). METHODS: In this double-blind randomized study (NCT01986855), patients with glycated hemoglobin (A1C) 7.0-10.5% and stage 3 CKD [estimated glomerular filtration rate (eGFR) ≥ 30 to < 60 mL/min/1.73 m(2)] who were undergoing treatment with standard diabetes therapy (or therapies) including insulin and/or sulfonylureas were randomized to once-daily ertugliflozin 5 mg, 15 mg, or placebo...
November 20, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29158864/-chronic-kidney-disease-associated-factors-etiologies-clinical-and-biological-parameters-at-lubumbashi-city-in-democratic-republic-of-congo
#5
Serge Muleka Ngoie, Philippe Mulenga, Olivier Mukuku, Christian Ngama Kakisingi, Cédrick Milindi Sangwa, Pascal Tshimwang Nawej, Claude Mulumba Mwamba, Dophra Nkulu Ngoy, Faustin Wa Pa Manda Muteta
Introduction: Chronic kidney disease is fast becoming a worldwide public health problem due to the increase of hypertension and diabetes mellitus, its main risk factors. In countries like DRC where majority of population are in the low income bracket, very few studies about this disease, usually diagnosed at a very advanced stage have been conducted. As a result of such, cases are not always properly taken care of and managed. Methods: We opted for a descriptive cross-sectional study and it was conducted during the period from July 2014 to July 2015 at CMDC dialysis service...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29157731/insulin-sensitivity-and-diabetic-kidney-disease-in-children-and-adolescents-with-type-2-diabetes-an-observational-analysis-of-data-from-the-today-clinical%C3%A2-trial
#6
Petter Bjornstad, Edward Nehus, Laure El Ghormli, Fida Bacha, Ingrid M Libman, Siripoom McKay, Steven M Willi, Lori Laffel, Silva Arslanian, Kristen J Nadeau
BACKGROUND: Diabetic kidney disease is a major cause of premature mortality in type 2 diabetes mellitus (T2DM). Worsening insulin sensitivity independent of glycemic control may contribute to the development of diabetic kidney disease. We investigated the longitudinal association of insulin sensitivity with hyperfiltration and increased albumin excretion in adolescents with T2DM. STUDY DESIGN: Observational prospective cohort study. SETTING & PARTICIPANTS: 532 TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) participants aged 12 to 17 years with T2DM duration less than 2 years at baseline...
November 17, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#7
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29155500/chinese-medicine-for-diabetic-kidney-disease-in-china
#8
REVIEW
Yumin Wen, Meihua Yan, Bingxuan Zhang, Ping Li
Diabetic kidney disease (DKD) is a major global public health concern due to its high prevalence and mortality, and high healthcare cost. Conventional Western therapies for DKD fail to provide favourable efficacy. Chinese medicine (CM) has been widely used to combat DKD in China and other Asian countries. The clinical effects and mechanism of CM in treating DKD have not been fully elucidated. This review summarizes current knowledge of CM therapeutic modalities for DKD, especially Chinese herbal medicine (CHM), and potential mechanisms...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29155498/global-impact-of-nephropathies
#9
REVIEW
Philip Kam-Tao Li, Terry King-Wing Ma
The global burden of chronic kidney disease (CKD) has increased substantially in recent years, partly attributed to the global epidemic of diabetes mellitus. In many countries including China, glomerulonephritis was the most common cause of end stage renal disease (ESRD). The mortality rate of dialysis patients can be as high as patients with colon, breast and prostate cancers. CKD has important socio-economic impact on the healthcare system and society. Increasing awareness and early detection of CKD cannot be overemphasized...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29155497/clinical-and-pathological-factors-associated-with-progression-of-diabetic-nephropathy
#10
REVIEW
Shuang Liang, Guang-Yan Cai, Xiang-Mei Chen
As an important complication of diabetic mellitus, diabetic kidney disease (DKD) is becoming a major cause of morbidity and mortality worldwide. Given the diminished quality of life and the economic cost, identification of the risk factors for DKD and initiation of in-time therapies are of great importance. The initiators of DKD include hyperglycemia and predisposing genes, while the promotors of DKD include hyperglycemia, albuminuria, hypertension, dyslipdemia, insulin resistance, anemia, long duration of diabetes, smoking, ethnicity, westernization, sex, age, and so on...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29155387/the-impact-of-chronic-kidney-disease-on-outcomes-following-percutaneous-coronary-interventions-versus-coronary-artery-bypass-grafting-in-patients-with-complex-coronary-artery-disease-5-year-follow-up-of-the-syntax-trial
#11
Milan Milojevic, Stuart J Head, Michael J Mack, Friedrich W Mohr, Marie-Claude Morice, Keith D Dawkins, David R Holmes, Patrick W Serruys, A Pieter Kappetein
AIMS: To investigate short-term and 5-year follow-up results from patients randomized to coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) with paclitaxel-eluting stents in the SYNTAX trial, focusing on patients with chronic kidney disease (CKD). METHODS AND RESULTS: Baseline glomerular filtration rate estimates (eGFR) were available in 1638 patients (PCI=852 and CABG=786). The Kidney Disease Improving Global Outcomes threshold was used to define staging of CKD...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#12
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
November 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29154962/a-novel-type-2-diabetes-mouse-model-of-combined-diabetic-kidney-disease-and-atherosclerosis
#13
Karin E Bornfeldt, Farah Kramer, Anna Batorsky, Jinkuk Choi, Kelly L Hudkins, Peter Tontonoz, Charles E Alpers, Jenny E Kanter
Diabetic kidney disease and atherosclerotic disease are major causes of morbidity and mortality associated with type 2 diabetes (T2D), and diabetic kidney disease is a major cardiovascular risk factor. The BTBR mouse strain with leptin-deficiency (Lep(ob)) has emerged as one of the best models of human diabetic kidney disease. However, no T2D mouse model of combined diabetic kidney disease and atherosclerosis exists. Our goal was to generate such a model. To this end, the LDL receptor was targeted for degradation via IDOL (inducible degrader of the LDL receptor) overexpression, using a liver-targeted adeno-associated virus (AAV-DJ/8) in BTBR wild-type (WT) and BTBR Lep(ob) (OB) mice...
November 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29154802/microrna-profiling-in-mda-mb-231-human-breast-cancer-cell-exposed-to-the-phaleria-macrocarpa-boerl-fruit-ethyl-acetate-fraction-pmeaf-through-iilumina-hi-seq-technologies-and-various-in-silico-bioinformatics-tools
#14
Nowroji Kavitha, Soundararajan Vijayarathna, Shanmugapriya, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Vasu Punj, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a famous traditional medicinal plant which exhibited cytotoxicity against various cancerous cells. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and heart disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: Recent studies have demonstrated a potent anticancer potential of P...
November 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29154443/long-term-outcomes-of-patients-with-type-2-diabetes-attending-a-multidisciplinary-diabetes-kidney-disease-clinic
#15
Serena Low, Su Chi Lim, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Eng Kuang Lim, Yan Li Shao, Winnie Chui, Sharon Fun, Chin Lian Chua, Tavintharan Subramaniam, Chee Fang Sum
BACKGROUND: The best model of care to retard diabetic kidney disease (DKD) in the clinic is under-unexplored. We investigated the long-term renal outcomes of a joint endocrinologist-nephrologist clinic. METHODS: This was a nested case-control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care Diabetes Centre (DC). Cases ("DKD clinic group") are patients seen at the CKD clinic after being referred by physicians in DC for management of DKD...
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29153995/longitudinal-estimated-gfr-trajectories-in-patients-with-and-without-type-2-diabetes-and-nephropathy
#16
Misghina Weldegiorgis, Dick de Zeeuw, Liang Li, Hans-Henrik Parving, Fan Fan Hou, Giuseppe Remuzzi, Tom Greene, Hiddo J L Heerspink
BACKGROUND: In clinical practice and clinical trials, changes in serum creatinine concentrations are used to evaluate changes in kidney function. It has been assumed that these changes follow a linear pattern when serum creatinine concentration is converted to estimated glomerular filtration rate (eGFR). However, the paradigm that kidney function declines linearly over time has been questioned by studies showing either linear or nonlinear patterns. To verify how this impacts on kidney end points in intervention trials, we analyzed eGFR trajectories in multiple clinical trials of patients with and without diabetes...
November 16, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29153659/a-simple-clinical-method-to-identify-women-at-higher-risk-of-preeclampsia
#17
Effie Viguiliouk, Alison L Park, Howard Berger, Michael P Geary, Joel G Ray
An outstanding issue is how to efficiently identify women at high risk of preeclampsia. This retrospective cohort study included 8672 pregnancies at a single centre in Toronto. We tested our simple method - presence vs. absence of≥1 major (pre-pregnancy BMI>30kg/m(2), chronic hypertension, pre-pregnancy diabetes mellitus and assisted reproductive therapy) or≥2 minor (prior stillbirth, age>40years, nulliparity, multifetal pregnancy, chronic kidney disease, and SLE) risk factors for PE. The RR of PE was 8...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153067/-detection-of-influenza-virus-infections-by-molecular-and-immunofluorescence-methods
#18
Deniz Yıldırım, Deniz Özdoğru Sağdıç, Buket Şeflek, Mehmet Çimentepe, İbrahim Bayram, Fügen Yarkın
Influenza virus infections are extremely important for human health due to the occurence of seasonal epidemics and pandemics worldwide. Influenza is associated with high morbidity and may result in serious complications such as life threatening viral or bacterial pneumonia. Especially, young children, older adults, patients with chronic diseases such as heart, lung, kidney, and diabetes and immunosuppressed people are at higher risk for complications and death from influenza virus infections. The aim of this study was to determine the incidence of influenza type A and B virus infections and influenza A virus subtypes in hospitalized patients with respiratory tract infections by real-time reverse transcriptase-polymerase chain reaction (RT-PCR, Sacace, Italy), conventional RT-PCR and direct immunofluorescence antibody (DFA, Argene SA, France) tests...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29151569/what-kind-of-incision-should-be-made-to-reduce-the-risk-of-incisional-hernia-in-kidney-transplantation
#19
Ihsan Yildız, Yavuz Savas Koca
BACKGROUND The incidence of incisional hernia following renal transplantation is 1.1% to 3.8%. The risk factors are immunosuppressive medications, impaired tissue quality, neuromuscular trauma due to the operation, and denervation. The incidence has been decreasing based on the shift from hockey-stick incision method to inguinal oblique incision method. The aim of this study was to minimize the development of incisional hernias due to renal transplantation. MATERIAL AND METHODS Twenty-four patients who underwent renal transplantation in 2015-2017 were retrospectively examined...
November 20, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29149967/early-prediction-of-cardiovascular-disease-in-kidney-transplant-recipients
#20
G Bilancio, M Celano, V Cozza, F Zingone, G Palladino, M Cirillo
Cardiovascular disease (CVD) is frequent after kidney transplantation (KT). This study investigated CVD prediction in KT by information available before KT or within 6 months after KT. The study cohort consisted of 629 patients with KT in 2005-10 and with adult age at KT. The end point was incidence up to 2015 of CVD (coronary heart disease, cerebrovascular disease, peripheral artery disease). Graft failure, non-CVD death with functioning graft, and loss to follow-up were considered competing events. CVD prediction was investigated for 34 variables by means of competing-risks regression...
November 2017: Transplantation Proceedings
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