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neonatal sepsi

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https://www.readbyqxmd.com/read/29036682/perinatal-risk-factors-for-neonatal-early-onset-group-b-streptococcal-sepsis-after-initiation-of-risk-based-maternal-intrapartum-antibiotic-prophylaxis-a-case-control-study
#1
Sridhar Santhanam, Sumita Arun, Grace Rebekah, Nithya J Ponmudi, Jolly Chandran, Ruby Jose, Atanu Kumar Jana
Objectives: To identify the perinatal risk factors for early-onset Group B Streptococcus (EOGBS) sepsis in neonates after inception of a risk-based maternal intrapartum antibiotic prophylaxis strategy in 2004. Design: Case control study. Methods: All newborn with early onset GBS sepsis (born between 2004 and 2013) were deemed to be "cases" and controls were selected in a 1:4 ratio. Results: More than three per vaginal (PV) examinations [odds ratio (OR) 8...
September 23, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#2
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29033034/antimicrobial-resistance-among-children-in-sub-saharan-africa
#3
REVIEW
Phoebe C M Williams, David Isaacs, James A Berkley
Antimicrobial resistance is an important threat to international health. Therapeutic guidelines for empirical treatment of common life-threatening infections depend on available information regarding microbial aetiology and antimicrobial susceptibility, but sub-Saharan Africa lacks diagnostic capacity and antimicrobial resistance surveillance. We systematically reviewed studies of antimicrobial resistance among children in sub-Saharan Africa since 2005. 18 of 1075 articles reviewed met inclusion criteria, providing data from 67 451 invasive bacterial isolates from inconsistently defined populations in predominantly urban tertiary settings...
October 9, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29031388/postnatal-rbc-arachidonic-and-docosahexaenoic-acids-deficiencies-are-associated-with-higher-risk-of-neonatal-morbidities-and-mortality-in-preterm-infants
#4
S Fares, M M Sethom, M B Hammami, M Cheour, M Feki, S Hadj-Taieb, S Kacem
Arachidonic (AA) and docosahexaenoic (DHA) acids are essential for the health and development of the neonate. Red blood cell (RBC) fatty acids were analyzed in 583 very low birth weight (VLBW) infants and 274 term infants using capillary gas chromatography. VLBW infants exhibited significantly lower RBC AA (13.0 ± 0.89 vs. 13.5 ± 0.98) and DHA (3.77 ± 0.60 vs. 3.80 ± 0.62), but higher n6:n3 ratio (3.97 ± 0.46 vs. 3.63 ± 0.37) than term infants. In VLBW infants, DHA was lower in those born with small for gestational age (3...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29029763/serotype-virulence-profile-antimicrobial-resistance-and-macrolide-resistance-determinants-in-streptococcus-agalactiae-isolates-in-pregnant-women-and-neonates-in-catalonia-spain
#5
Yuly López, Elena Parra, Virginio Cepas, Isabel Sanfeliú, Teresa Juncosa, Antonia Andreu, Mariona Xercavins, Josefa Pérez, Sergi Sanz, Andrea Vergara, Jordi Bosch, Sara Maria Soto
INTRODUCTION: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed...
October 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29025624/tackling-antimicrobial-resistance-in-neonatal-sepsis
#6
Laura Folgori, Sally J Ellis, Julia A Bielicki, Paul T Heath, Mike Sharland, Manica Balasegaram
No abstract text is available yet for this article.
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29022924/listeriosis-in-pregnancy-under-diagnosis-despite-over-treatment
#7
Y Fouks, S Amit, A Many, A Haham, D Mandel, S Shinar
OBJECTIVE: To compare the symptomatology of pregnant women with suspected listeriosis to culture confirmed listeriosis. STUDY DESIGN: All cases of suspected and culture confirmed pregnancy-associated listeriosis from a single center were retrospectively reviewed assessing demographics, clinical, laboratory and pathological findings, and maternal, fetal and neonatal outcomes. RESULTS: Listeriosis was identified in seven patients, none of whom belonged to the 117 women with suspected listeriosis...
October 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29019470/progress-in-the-management-of-neonatal-sepsis-the-importance-of-a-consensus-definition
#8
James L Wynn, Richard A Polin
No abstract text is available yet for this article.
October 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29016584/morbidities-and-outcome-of-a-neonatal-intensive-care-in-western-nepal
#9
Sudhir Adhikari, Kalipatanam Seshagiri Rao, Ganesh B K, Namraj Bahadur
BACKGROUND: Neonatal mortality rate of developing countries is declining over decades. In the recent years increasing number of preterm and high risk neonates have facilities for tertiary care treatment. The aim of the study was to assess the morbidities and outcome of neonatal intensive care admissions. METHODS: It was a retrospective observational study carried out in neonatal intensive care unit of the Manipal Teaching Hospital, Pokhara, Nepal from January 2014 to December 2015...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29016494/maternal-and-neonatal-outcomes-in-indicated-preterm-births-based-on-the-intended-mode-of-delivery
#10
Spencer G Kuper, Rachel A Sievert, Robin Steele, Joseph R Biggio, Alan T Tita, Lorie M Harper
OBJECTIVE: To compare maternal and neonatal outcomes in women who underwent induction of labor or planned cesarean delivery in indicated preterm births before 34 weeks of gestation. METHODS: We conducted a retrospective cohort study of all indicated singleton preterm births (23-34 weeks of gestation) in a tertiary center from 2011 to 2014. The primary maternal outcome was a composite of early postpartum hemorrhage, blood transfusion, operative complications, postpartum complications, and clinical chorioamnionitis...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29016490/neonatal-morbidity-and-maternal-complication-rates-in-women-with-a-delivery-body-mass-index-of-60-or-higher
#11
Tana Kim, Sabrina C Burn, Ananta Bangdiwala, Samantha Pace, Phillip Rauk
OBJECTIVE: To investigate neonatal morbidity and maternal complication rates with delivery body mass index (BMI) 60 or greater. METHODS: This retrospective, multicenter cohort study included singleton pregnancies between 23 and 42 weeks of gestation from January 2005 to April 2016. Women with BMI 60 or greater were compared with a random sample of women with BMI 30-59. The primary outcome, composite neonatal morbidity, was defined as 5-minute Apgar score less than 7, hypoglycemia, respiratory distress syndrome, sepsis, hospital stay greater than 5 days, neonatal intensive care unit admission, or neonatal death...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28989567/conjugated-hyperbilirubinemia-presenting-in-first-fourteen-days-in-term-neonates
#12
Fang Kuan Chiou, Christina Ong, Kong Boo Phua, Fares Chedid, Ajmal Kader
AIM: To describe the etiology and characteristics of early-onset conjugated hyperbilirubinemia (ECHB) presenting within 14 d of life in term neonates. METHODS: Retrospective review was performed of term infants up to 28-d-old who presented with conjugated hyperbilirubinemia (CHB) at a tertiary center over a 5-year period from January 2010 to December 2014. CHB is defined as conjugated bilirubin (CB) fraction greater than 15% of total bilirubin and CB greater or equal to 25 μmol/L...
September 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28987479/nurses-early-recognition-of-neonatal-sepsis
#13
Michele Boettiger, Lynda Tyer-Viola, Joseph Hagan
OBJECTIVE: To determine nurses' perceptions of the most common physiologic and behavioral indicators of neonatal sepsis. DESIGN: Descriptive correlational study. SETTING: A women's and children's hospital in an academic medical center in the southwestern United States. PARTICIPANTS: Nurses (N = 181) who cared for neonates in the mother-infant and NICU settings. METHODS: Participants completed an e-mail survey developed from the literature to ascertain their perceptions of which physiologic and behavioral indicators were most often associated with neonatal sepsis...
October 4, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28984265/simultaneous-two-site-blood-culture-in-diagnosis-of-neonatal-sepsis-few-concerns-authors-reply
#14
Amit Upadhyay, Priya Tomar
No abstract text is available yet for this article.
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28984264/simultaneous-two-site-blood-culture-in-diagnosis-of-neonatal-sepsis-few-concerns
#15
Jogender Kumar, Amitabh Singh
No abstract text is available yet for this article.
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28984251/impact-of-antibiotic-policy-on-antibiotic-consumption-in-a-neonatal-intensive-care-unit-in-india
#16
Dasaratha Ramaiah Jinka, Sumanth Gandra, Gerardo Alvarez-Uria, Nuria Torre, Durgesh Tadepalli, RaghuPrakash Reddy Nayakanti
OBJECTIVE: To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU). METHODS: This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982710/identification-of-extremely-premature-infants-at-low-risk-for-early-onset-sepsis
#17
Karen M Puopolo, Sagori Mukhopadhyay, Nellie I Hansen, C Michael Cotten, Barbara J Stoll, Pablo J Sanchez, Edward F Bell, Abhik Das, Angelita M Hensman, Krisa P Van Meurs, Myra H Wyckoff
BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS: Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by isolation of pathogenic species from blood or cerebrospinal fluid culture at ≤72 hours age...
October 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28981079/anti-microbial-stewardship-antibiotic-use-in-well-appearing-term-neonates-born-to-mothers-with-chorioamnionitis
#18
N Money, J Newman, S Demissie, P Roth, J Blau
OBJECTIVE: To determine if implementation of a protocol based on a neonatal early-onset sepsis (EOS) calculator developed by Kaiser Permanente would safely reduce antibiotic use in well-appearing term infants born to mothers with chorioamnionitis in the unique setting of an Observation Nursery. STUDY DESIGN: Data obtained from a retrospective chart review of well-appearing term infants born between 2009 and 2016 were entered into the EOS calculator to obtain management recommendations...
October 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28980093/incidence-of-fever-and-positive-bacterial-cultures-in-neonates-receiving-prostaglandin
#19
Fares Alghanem, Stephanie L Rakestraw, Kurt R Schumacher, Gabe E Owens
Prostaglandin E (PGE1) is necessary to maintain ductus arteriosus patency in many newborns with congenital heart disease. Because PGE1 therapy commonly leads to fever, and given this population's fragile state, a complete sepsis workup is often performed in febrile, but otherwise asymptomatic, patients. This practice of liberal evaluation with bacterial cultures, empiric antibiotic treatment, and delays in essential surgical intervention may result in poor resource utilization and lead to increased iatrogenic morbidity...
October 4, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28979257/multiplexed-lateral-flow-test-for-detection-and-differentiation-of-cronobacter-sakazakii-serotypes-o1-and-o2
#20
Eva J Scharinger, Richard Dietrich, Tobias Wittwer, Erwin Märtlbauer, Kristina Schauer
The ubiquitous and opportunistic pathogen Cronobacter sakazakii is responsible for severe meningitis, sepsis, and necrotizing enterocolitis in neonates and infants associated with ingestion of contaminated powdered infant formula (PIF). The current ISO method for isolation and detection of Cronobacter spp. is laborious, time-consuming and expensive. In this study, a multiplexed lateral flow test strip was developed to rapidly detect and simultaneously serotype O1 and O2 C. sakazakii serotypes. The assay is based on two monoclonal antibodies (MAb) that specifically bind to the lipopolysaccharides (LPS) of these pathogens...
2017: Frontiers in Microbiology
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