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https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#1
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141052/association-between-urinary-manganese-and-blood-pressure-results-from-national-health-and-nutrition-examination-survey-nhanes-2011-2014
#2
Cynthia Wu, Jessica G Woo, Nanhua Zhang
Manganese is a trace mineral required for metabolism, growth and tissue formation, and reproduction. It is mainly obtained through food and water, as well as through occupational exposure. This study used data from National Health and Nutrition Examination Survey, combining the 2011-12 and 2013-14 cycles. We conducted linear regression analyses on urinary manganese and blood pressure. Significant negative associations (p<0.01) between urinary manganese and both systolic and diastolic blood pressure existed after adjusting for age, sex, body mass index, race/ethnicity, and status of taking antihypertensive medication...
2017: PloS One
https://www.readbyqxmd.com/read/29140874/hiv-and-age-do-not-synergistically-affect-age-related-t-cell-markers
#3
Shelli Farhadian, Emilie Jalbert, Yanhong Deng, Matthew Bidwell Goetz, Lesley S Park, Amy Justice, Robert Dubrow, Brinda Emu
INTRODUCTION: Despite major progress in controlling HIV disease through anti-retroviral therapy (ART), changes in immune phenotype and function persist in individuals with chronic HIV, raising questions about accelerated aging of the immune system. METHODS: We conducted a cross sectional study (2005-2007) of HIV-infected (n=111) and uninfected (n=114) males from the Veterans Aging Cohort Study. All HIV-infected subjects were on ART with VL<400 copies/mL for at least three years...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140805/health-related-decisions-for-serious-illness-among-ethnically-diverse-older-adults
#4
Zahra Rahemi, Christine Lisa Williams, Ruth Marchand Tappen, Gabriella Anna Engstrom
We investigated the influence of sociodemographic factors, acculturation, ethnicity, health status, and spirituality on older adults' health-related decisions when confronted with a choice between competing options. The sample included 451 participants: African Americans (15.74%), Afro-Caribbeans (25.5%), European Americans (36.36%), and Hispanic Americans (22.4%). Compared with others, European Americans and Hispanic Americans favored quality of life over a lengthy life. Sociodemographic factors, acculturation, ethnicity, health status, and spirituality accounted for variations of decisions...
November 14, 2017: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/29140588/family-management-of-childhood-chronic-conditions-does-it-make-a-difference-if-the-child-has-an-intellectual-disability
#5
Marcia Van Riper, George J Knafl, Cecelia Roscigno, Kathleen A Knafl
The purpose of this analysis was to assess the applicability of the Family Management Measure (FaMM) to families in which there was a child with an intellectual disability versus a chronic condition. Drawing on data from 571 parents of children with a chronic physical condition and 539 parents of children with Down syndrome, we compared the two groups across the six FaMM scales. After accounting for the covariate effects of race, ethnicity, family income, and child age, we found significant differences in four of the six FaMM scales, with parents of children with Down syndrome reporting a significantly more positive view on the Condition Management Effort and View of Condition Impact scales and a significantly less positive view on the Child's Daily Life and Condition Management Ability scales than parents of children with a chronic physical condition...
November 15, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29140535/socioeconomic-disparities-in-small-for-gestational-age-birth-and-preterm-birth
#6
Tracey Bushnik, Seungmi Yang, Jay S Kaufman, Michael S Kramer, Russell Wilkins
BACKGROUND: Maternal socioeconomic disadvantage has been associated with increased risk of small-for-gestational-age birth and preterm birth. Few studies, however, have considered maternal education and income simultaneously to better understand the mechanisms underlying perinatal health disparities. This analysis examines both maternal education and income and their association with the risk of small-for-gestational-age birth and preterm birth. DATA AND METHODS: The study is based on 127,694 singleton live births from the 2006 Canadian Birth-Census Cohort, a national cohort of births registered from May 2004 to May 2006 that were linked to the 2006 long-form Census...
November 15, 2017: Health Reports
https://www.readbyqxmd.com/read/29140229/epidemiology-of-imported-malaria-cases-in-japan-2006-2014-a-sentinel-traveler-surveillance-approach
#7
Atsuhiro Kanayama, Yuzo Arima, Tamano Matsui, Koki Kaku, Hitomi Kinoshita, Kazunori Oishi
Malaria continues to be imported into Japan. To better assess the risk of imported malaria, we describe malaria species, suspected country/area of infection (accounting for the number of travelers), demographic characteristics, clinical manifestation, and healthcare access, based on the national surveillance data from 2006 to 2014. Among 557 cases, the median age was 33 years (range: 1-83 years), and 76% were male; 306 (55%) were classified as Japanese based on the reported name. The majority were Plasmodium falciparum infections (58%), followed by Plasmodium vivax infections (30%)...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140107/a-cross-sectional-study-of-ethnicity-based-differences-in-treatment-seeking-for-symptoms-of-acute-coronary-syndrome
#8
Emma Iacoe, Pamela A Ratner, Sabrina T Wong, Martha H Mackay
BACKGROUND: Patient-related delays in acquiring medical care for symptoms of acute coronary syndrome remain unacceptably long. Many clinical and sociodemographic characteristics associated with treatment-seeking delay are known; however, ethnicity has not been extensively evaluated. OBJECTIVE: The purpose of this study was to examine ethnicity-based differences in the time-to-treatment-seeking intervals of patients experiencing symptoms of acute coronary syndrome...
November 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29139590/breast-density-in-screening-mammography-in-indian-population-is-it-different-from-western-population
#9
Tulika Singh, Niranjan Khandelwal, Veenu Singla, Dileep Kumar, Madhu Gupta, Gurpreet Singh, Amanjit Bal
Mammography is the only method presently considered appropriate for mass screening of breast cancer. However, higher breast density was strongly associated with lower mammographic sensitivity. Breast density is also identified as independent and strongest risk factors for breast cancer. Studies have shown women with high breast density have four to six times increased risk of breast cancer as compare to women with fatty breast. It varies between different age group it generally decreases with increasing age in postmenopausal women and it can be different in different ethnic groups and people from different geographical areas...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139198/factors-affecting-drug-development-strategies-in-asian-global-clinical-trials-for-drug-approval-in-japan
#10
Kunihito Asano, Yoshiaki Uyama, Masahiro Tohkin
We assessed the current status of Asian global clinical trials (GCTs) and factors, such as therapeutic areas, main metabolic enzymes targeted, approval status in the United States or the European Union, development strategies, influencing drug-development strategies in Asian GCTs and in general GCTs for drug approval in Japan. The findings suggested that region-specific diseases in Asia, intrinsic and extrinsic ethnic differences between Japanese/Asian and Caucasian populations, and the status of the drugs' development in the United States or the European Union all affected Asian GCTs...
November 15, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29139186/factors-associated-with-home-hazards-findings-from-the-malaysian-elders-longitudinal-research-study
#11
Muhammad H Romli, Maw P Tan, Lynette Mackenzie, Meryl Lovarini, Shahrul B Kamaruzzaman, Lindy Clemson
AIM: Previous studies have investigated home hazards as a risk factor for falls without considering factors associated with the presence of home hazards. The present study aimed to determine patterns of home hazards among urban community-dwelling older Malaysians, and to identify factors contributing to home hazards. METHODS: Cross-sectional data from the initial wave of the Malaysian Elders Longitudinal Research study were used. Basic demographics were obtained from the Global Questionnaire...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29139058/expression-and-serum-levels-of-mucin-5ac-muc5ac-as-a-biomarker-for-cholangiocarcinoma-a-meta-analysis
#12
Noel Pabalan, Sutawadee Sukcharoensin, Kritiya Butthongkomvong, Hamdi Jarjanazi, Veerachai Thitapakorn
AIM: The potential of biomarkers in detecting early cholangiocarcinoma (CCA) is facilitated by examining CCA-associated proteins from primary studies. One such protein is mucin 5AC (MUC5AC) but inconsistency of reported associations between its expression/serum levels and CCA prompts a meta-analysis to obtain more precise estimates. METHODS: A literature search yielded 17 included articles where multiple data in some raised the number of studies to 22. We calculated pooled odds ratios (OR) and 95% confidence intervals from negative and positive readings of MUC5AC levels...
November 15, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29138590/the-prevalence-of-probable-neuropathic-pain-in-the-us-results-from-a-multimodal-general-population-health-survey
#13
Marco D DiBonaventura, Alesia Sadosky, Kristen Concialdi, Markay Hopps, Ian Kudel, Bruce Parsons, Joseph C Cappelleri, Patrick Hlavacek, Andrea H Alexander, Brett R Stacey, John D Markman, John T Farrar
Background: The prevalence of neuropathic pain (NeP) has been estimated within specific health conditions; however, there are no published data on its broad prevalence in the US. The current exploratory study addresses this gap using the validated PainDetect questionnaire as a screener for probable NeP in a general-population health survey conducted with a multimodal recruitment strategy to maximize demographic representativeness. Materials and methods: Adult respondents were recruited from a combination of Internet panels, telephone lists, address lists, mall-based interviews, and store-receipt invitations using a random stratified-sampling framework, with strata defined by age, sex, and race/ethnicity...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29138232/relationship-of-echocardiographic-z-scores-adjusted-for-body-surface-area-to-age-sex-race-and-ethnicity-the-pediatric-heart-network-normal-echocardiogram-database
#14
Leo Lopez, Steven Colan, Mario Stylianou, Suzanne Granger, Felicia Trachtenberg, Peter Frommelt, Gail Pearson, Joseph Camarda, James Cnota, Meryl Cohen, Andreea Dragulescu, Michele Frommelt, Olukayode Garuba, Tiffanie Johnson, Wyman Lai, Joseph Mahgerefteh, Ricardo Pignatelli, Ashwin Prakash, Ritu Sachdeva, Brian Soriano, Jonathan Soslow, Christopher Spurney, Shubhika Srivastava, Carolyn Taylor, Poonam Thankavel, Mary van der Velde, LuAnn Minich
BACKGROUND: Published nomograms of pediatric echocardiographic measurements are limited by insufficient sample size to assess the effects of age, sex, race, and ethnicity. Variable methodologies have resulted in a wide range of Z scores for a single measurement. This multicenter study sought to determine Z scores for common measurements adjusted for body surface area (BSA) and stratified by age, sex, race, and ethnicity. METHODS AND RESULTS: Data collected from healthy nonobese children ≤18 years of age at 19 centers with a normal echocardiogram included age, sex, race, ethnicity, height, weight, echocardiographic images, and measurements performed at the Core Laboratory...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29138203/does-the-impact-of-a-plant-based-diet-during-pregnancy-on-birth-weight-differ-by-ethnicity-a-dietary-pattern-analysis-from-a-prospective-canadian-birth-cohort-alliance
#15
Michael A Zulyniak, Russell J de Souza, Mateen Shaikh, Dipika Desai, Diana L Lefebvre, Milan Gupta, Julie Wilson, Gita Wahi, Padmaja Subbarao, Allan B Becker, Piush Mandhane, Stuart E Turvey, Joseph Beyene, Stephanie Atkinson, Katherine M Morrison, Sarah McDonald, Koon K Teo, Malcolm R Sears, Sonia S Anand
OBJECTIVE: Birth weight is an indicator of newborn health and a strong predictor of health outcomes in later life. Significant variation in diet during pregnancy between ethnic groups in high-income countries provides an ideal opportunity to investigate the influence of maternal diet on birth weight. SETTING: Four multiethnic birth cohorts based in Canada (the NutriGen Alliance). PARTICIPANTS: 3997 full-term mother-infant pairs of diverse ethnic groups who had principal component analysis-derived diet pattern scores-plant-based, Western and health-conscious-and birth weight data...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138129/patient-portal-utilization-among-ethnically-diverse-low-income-older-adults-observational-study
#16
Thomas A Arcury, Sara A Quandt, Joanne C Sandberg, David P Miller, Celine Latulipe, Xiaoyan Leng, Jenifer W Talton, Kathryn P Melius, Alden Smith, Alain G Bertoni
BACKGROUND: Patient portals can improve patient communication with providers, provide patients with greater health information access, and help improve patient decision making, if they are used. Because research on factors facilitating and limiting patient portal utilization has not been conceptually based, no leverage points have been indicated for improving utilization. OBJECTIVE: The primary objective for this analysis was to use a conceptual framework to determine potentially modifiable factors affecting patient portal utilization by older adults (aged 55 years and older) who receive care at clinics that serve low income and ethnically diverse communities...
November 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29137951/triple-negative-breast-cancer-stem-cells-and-african-ancestry
#17
REVIEW
Evelyn Jiagge, Dhananjay Chitale, Lisa A Newman
Triple-negative breast cancers (TNBC) are more common among African ancestry populations, such as African Americans and western, sub-Saharan Africans, compared to European ancestry populations. This phenotype prevalence contributes to breast cancer outcome disparities between African Americans and Caucasian Americans. Breast cancer stem cells represent the tumor subpopulation responsible for metastatic virulence and ongoing research seeks to characterize the extent to which TNBC versus non-TNBC stem cells may differ...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137950/linking-race-cancer-outcomes-and-tissue-repair
#18
REVIEW
Jung S Byun, Samson Park, Ambar Caban, Alana Jones, Kevin Gardner
The burden of cancer in the United States is unevenly spread across its different populations, with stark differences in both disease prevalence and outcome based on race and ethnicity. Although a large portion of these differences can be explained by a variety of socio-behavioral and socio-economic factors, even after these exposures are taken into consideration, significant disparities persist. In this review, we explore a conceptual framework of biological theories and unifying concepts, based on an evolutionary perspective, that may help better define common guiding principles for exploration of underlying etiologies of cancer health disparities...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137902/effects-of-opioid-medications-on-cognitive-skills-among-emergency-department-patients
#19
Catherine A Marco, Dennis Mann, Jordan Rasp, Michael Ballester, Oswald Perkins, Michael B Holbrook, Kyle Rako
INTRODUCTION: Treatment for pain and related conditions has been identified as the most common reason for Emergency Department (ED) visits. Concerns exist regarding the effects of opioid pain medications on cognition and patient ability to consent for procedures, hospital admission, or to refuse recommended medical interventions. This study was undertaken to identify cognitive skills before and after opioid pain medication in the ED setting. METHODS: This was a prospective study comparing performance on the Mini-Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA) before and after administration of opioid pain medications...
November 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29137553/relationship-between-pregnancy-complications-and-psychiatric-disorders-a-population-based-study-with-a-matched-control-group
#20
Christina D Kang-Yi, Sara L Kornfield, C Neill Epperson, David S Mandell
OBJECTIVES: This study sought to identify whether pregnancy complications differ between women with and without a psychiatric disorder diagnosis prior to pregnancy. METHODS: Women who gave birth between 2007 and 2009 in Pennsylvania and were enrolled in Medicaid from one year prior to their pregnancy until their delivery were included (N=9,930); those with psychiatric disorders were compared with a matched control group (N=4,965 for each). Logistic regression analysis estimated the odds of having a pregnancy complication among those with a psychiatric diagnosis prior to pregnancy, adjusting for demographic characteristics and chronic general medical conditions...
November 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
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