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https://www.readbyqxmd.com/read/28771790/motoneuron-activity-is-required-for-enhancements-in-functional-recovery-after-peripheral-nerve-injury-in-exercised-female-mice
#1
Poonam B Jaiswal, Jack K Tung, Robert E Gross, Arthur W English
Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuronal inhibition. Moderate daily exercise in the form of interval treadmill-training (IT) applied following a peripheral nerve injury results in enhanced motor axon regeneration and muscle fiber reinnervation in female mice...
August 3, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28757853/ultrasound-guided-adductor-and-sciatic-nerve-block-two-in-one-approach-at-mid-thigh-level
#2
Amarjeet Kumar, Chandni Sinha, Ajeet Kumar, Poonam Kumari
No abstract text is available yet for this article.
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28732667/contribution-of-bdnf-trkb-signalling-in-the-racc-to-the-development-of-pain-related-aversion-via-activation-of-erk-in-rats-with-spared-nerve-injury
#3
Xu Wang, Le Zhang, Yufeng Zhan, Dengping Li, Yuangui Zhang, Gongming Wang, Mengyuan Zhang
The rostral anterior cingulate cortex (rACC) is a key structure in mediating the negative affective component of chronic pain. Brain-derived neurotrophic factor (BDNF) is known to play a critical role in activity-dependent synaptic plasticity, learning and memory. It has been shown that BDNF signalling in the rACC might be involved in spontaneous pain-related aversion, but its underlying mechanism is still largely unknown. To address this question, we measured the mRNA and protein levels of BDNF in the rACC after nerve injury and found that BDNF expression was markedly higher in nerve-injured rats than in controls...
September 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28731982/peripheral-oxytocin-receptors-inhibit-the-nociceptive-input-signal-to-spinal-dorsal-horn-wide-dynamic-range-neurons
#4
Abimael González-Hernández, Alfredo Manzano-García, Guadalupe Martínez-Lorenzana, Irma A Tello-García, Martha Carranza, Carlos Arámburo, Miguel Condés-Lara
Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn participate in a selective inhibition of the neuronal activity mediated by Aδ and C fibers but not Aβ fibers. This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral OT blocked the first sensorial activity of Aδ and C fibers recorded in the spinal cord neurons...
July 19, 2017: Pain
https://www.readbyqxmd.com/read/28713527/comparison-of-continuous-femoral-nerve-block-with-and-without-combined-sciatic-nerve-block-after-total-hip-arthroplasty-a-prospective-randomized-study
#5
Shoji Nishio, Shigeo Fukunishi, Tomokazu Fukui, Yuki Fujihara, Shohei Okahisa, Yu Takeda, Shinichi Yoshiya
In association with the growing interests in pain management, several modalities to control postoperative pain have been proposed and examined for the efficacy in the recent studies. Various modes of peripheral nerve block have been proposed and the effectiveness and safety have been examined for each of those techniques. We have described our clinical experiences, showing that continuous femoral nerve block could provide a satisfactory analgesic effect after total hip arthroplasty (THA) procedure. In this study, we compared the effectiveness and safety of continuous femoral nerve block with and without sciatic nerve blockade on pain control after THA...
June 23, 2017: Orthopedic Reviews
https://www.readbyqxmd.com/read/28700113/na-k-atpase-coupled-to-endothelin-receptor-type-b-stimulates-peripheral-nerve-regeneration-via-lactate-signaling
#6
Nguyen H Tu, Tayo Katano, Shinji Matsumura, Nobuo Funatsu, Vuong Minh Pham, Jun-Ichi Fujisawa, Seiji Ito
We have recently demonstrated that endothelin (ET) is functionally coupled to Nax , a Na(+) concentration-sensitive Na(+) channel for lactate release via ET receptor type B (ETB R) and is involved in peripheral nerve regeneration in a sciatic nerve transection-regeneration mouse model. Nax is known to interact directly with Na(+) /K(+) -ATPase, leading to lactate production in the brain. To investigate the role of Na(+) /K(+) -ATPase in peripheral nerve regeneration, in the present study we applied ouabain, a Na(+) /K(+) -ATPase inhibitor, to the cut site for 4 weeks with an osmotic pump...
July 12, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28697780/local-infiltration-of-analgesia-and-sciatic-nerve-block-provide-similar-pain-relief-after-total-knee-arthroplasty
#7
Hidenori Tanikawa, Kengo Harato, Ryo Ogawa, Tomoyuki Sato, Shu Kobayashi, So Nomoto, Yasuo Niki, Kazunari Okuma
BACKGROUND: Although femoral nerve block provides satisfactory analgesia after total knee arthroplasty (TKA), residual posterior knee pain may decrease patient satisfaction. We conducted a randomized controlled trial to clarify the efficacy of the sciatic nerve block (SNB) and local infiltration of analgesia with steroid (LIA) regarding postoperative analgesia after TKA, when administrated in addition to femoral nerve block (FNB). METHODS: Seventy-eight patients were randomly allocated to the two groups: concomitant administration of FNB and SNB or FNB and LIA...
July 11, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28697028/sciatic-popliteal-fossa-catheter-for-pediatric-pain-management-of-sickle-cell-crisis-a-case-report
#8
Garret Weber, Sherry Liao, Micah Alexander Burns
Sickle cell crisis, or vaso-occlusive crisis (VOC), is a major cause of hospitalizations for adults and children with sickle cell disease, and is associated with increased morbidity and mortality. Despite prompt pharmacological treatment and multimodal pain management, acute pain during a VOC is often not adequately controlled in the pediatric population. We placed a continuous popliteal sciatic nerve block under ultrasound guidance in a pediatric patient for localized refractory pain during a VOC, resulting in improved pain control with preserved sensorimotor function...
July 10, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28682956/diphenyleneiodonium-mitigates-bupivacaine-induced-sciatic-nerve-damage-in-a-diabetic-neuropathy-rat-model-by-attenuating-oxidative-stress
#9
Zhong-Hua Ji, Zhong-Jie Liu, Zi-Ting Liu, Wei Zhao, Brian A Williams, Hong-Fei Zhang, Le Li, Shi-Yuan Xu
BACKGROUND: Increased oxidative stress has been linked to local anesthetic-induced nerve injury in a diabetic neuropathy (DN) rat model. The current study explores the effects of diphenyleneiodonium (DPI) chloride, an NADPH oxidase (NOX) inhibitor, on bupivacaine-induced sciatic nerve injury in DN rats. METHODS: A rat DN model was established through high-fat diet feeding and streptozotocin injection. The model was confirmed via testing (i) blood glucose, (ii) hindpaw allodynia responses to von Frey (VF) monofilaments, (iii) paw withdrawal thermal latency (PWTL), and (iv) nerve conduction velocity (NCV)...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28663654/successful-management-of-above-knee-amputation-with-combined-and-modified-nerve-blocks
#10
T Senthil Kumar, K Indu, S Parthasarathy
We report a successful management of a case of methicillin-resistant Staphylococcus aureus positive right lower limb cellulitis for above knee amputation under combined nerve blocks. The ongoing sepsis, thrombocytopenia, and severe respiratory infection with wheeze made us avoid both neuraxial block and general anesthesia and plan for a nerve block. We instituted a modified high inguinal femoral block along with sciatic and lateral femoral nerve blocks separately to successfully conduct the case. We decided to report as there were not as many cases as ours in the literature...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28662295/%C3%AE-9-containing-nicotinic-acetylcholine-receptors-and-the-modulation-of-pain
#11
REVIEW
Arik J Hone, Denis Servent, J Michael McIntosh
Neuropathic pain is a complex and debilitating syndrome for which there are few effective pharmacological treatments. Opioid-based medications are initially effective for acute pain but tolerance to their analgesic effects quickly develops and long-term use often leads to physical dependence and addiction. Furthermore, neuropathic pain is generally resistant to non-steroidal anti-inflammatory drugs. Other classes of medications including antidepressants, antiepileptics, and voltage-gated calcium channel (VGCC) inhibitors are only partially effective in most patients, may be associated with significant side effects, and have few disease modifying effects on the underlying pathology...
June 29, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28656058/melatonin-suppresses-neuropathic-pain-via-mt2-dependent-and-independent-pathways-in-dorsal-root-ganglia-neurons-of-mice
#12
Jia-Ji Lin, Ye Lin, Tian-Zhi Zhao, Chun-Kui Zhang, Ting Zhang, Xiao-Li Chen, Jia-Qi Ding, Ting Chang, Zhuo Zhang, Chao Sun, Dai-Di Zhao, Jun-Lin Zhu, Zhu-Yi Li, Jin-Lian Li
Melatonin (Mel) and its receptors (MT1 and MT2) have a well-documented efficacy in treating different pain conditions. However, the anti-nociceptive effects of Mel and Mel receptors in neuropathic pain (NP) are poorly understood. To elucidate this process, pain behaviors were measured in a dorsal root ganglia (DRG)-friendly sciatic nerve cuffing model. We detected up-regulation of MT2 expression in the DRGs of cuff-implanted mice and its activation by the agonist 8-M-PDOT (8MP). Also, Mel attenuated the mechanical and thermal allodynia induced by cuff implantation...
2017: Theranostics
https://www.readbyqxmd.com/read/28617716/hybrid-blocks-for-total-knee-arthroplasty-a-technical-description
#13
David F Johnston, Rakesh V Sondekoppam, Vishal Uppal, James L Howard, Sugantha Ganapathy
This narrative review article aims to examine current evidence of knee innervation in order to develop a technique of targeting pure sensory innervation of the knee joint without compromising motor function. A literature review of knee innervation was performed to gain an anatomic understanding of terminal sensory branches of the relevant target nerves (femoral, obturator, sciatic, and lateral femoral cutaneous). Pure sensory block of the knee joint is challenging due to important contributions from the muscular innervation close to the joint and the variability of nerves afferents contained within and around the adductor canal...
June 14, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28612319/involvement-of-nf-%C3%AE%C2%BAb-and-the-cx3cr1-signaling-network-in-mechanical-allodynia-induced-by-tetanic-sciatic-stimulation
#14
Zhe-Chen Wang, Li-Hong Li, Chao Bian, Liu Yang, Ning Lv, Yu-Qiu Zhang
Tetanic stimulation of the sciatic nerve (TSS) triggers long-term potentiation in the dorsal horn of the spinal cord and long-lasting pain hypersensitivity. CX3CL1-CX3CR1 signaling is an important pathway in neuronal-microglial activation. Nuclear factor κB (NF-κB) is a key signal transduction molecule that regulates neuroinflammation and neuropathic pain. Here, we set out to determine whether and how NF-κB and CX3CR1 are involved in the mechanism underlying the pathological changes induced by TSS. After unilateral TSS, significant bilateral mechanical allodynia was induced, as assessed by the von Frey test...
June 13, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28600141/chlorpyrifos-and-chlorpyrifos-oxon-impair-the-transport-of-membrane-bound-organelles-in-rat-cortical-axons
#15
Jie Gao, Sean X Naughton, Wayne D Beck, Caterina M Hernandez, Guangyu Wu, Zhe Wei, Xiangkun Yang, Michael G Bartlett, Alvin V Terry
Chlorpyrifos (CPF) is an extensively used organophosphorus pesticide that has recently come under increasing scrutiny due to environmental health concerns particularly its association with neurodevelopmental defects. While the insecticidal actions and acute toxicity of CPF are attributed to its oxon metabolite (CPO) which potently inhibits the cholinergic enzyme acetylcholinesterase (AChE), there is significant evidence that CPF, CPO, and other organophosphates may affect a variety of neuronal targets and processes that are not directly related to AChE...
June 12, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28592614/cannabinoid-cb2-agonist-gw405833-suppresses-inflammatory-and-neuropathic-pain-through-a-cb1-mechanism-that-is-independent-of-cb2-receptors-in-mice
#16
Ai-Ling Li, Lawrence M Carey, Ken Mackie, Andrea G Hohmann
GW405833, widely accepted as a cannabinoid receptor 2 (CB2) agonist, suppresses pathologic pain in preclinical models without the unwanted central side effects of cannabinoid receptor 1 (CB1) agonists; however, recent in vitro studies have suggested that GW405833 may also behave as a noncompetitive CB1 antagonist, suggesting that its pharmacology is more complex than initially appreciated. Here, we further investigated the pharmacologic specificity of in vivo antinociceptive actions of GW405833 in models of neuropathic (i...
August 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28592324/comparison-of-local-infiltration-analgesia-and-sciatic-nerve-block-for-pain-control-after-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#17
Li-Ping Ma, Ying-Mei Qi, Dong-Xu Zhao
BACKGROUND: This meta-analysis aimed to perform a meta-analysis to evaluate the efficiency and safety between local infiltration analgesia (LIA) and sciatic nerve block (SNB) when combined with femoral nerve block (FNB) after total knee arthroplasty (TKA). METHODS: A systematic search was performed in MEDLINE (1966-2017.04), PubMed (1966-2017.04), Embase (1980-2017.04), ScienceDirect (1985-2017.04), and the Cochrane Library. Only high-quality studies were selected...
June 7, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28579906/dexmedetomidine-attenuates-neuropathic-pain-in-chronic-constriction-injury-by-suppressing-nr2b-nf-%C3%AE%C2%BAb-and-inos-activation
#18
Feng Liang, Miao Liu, Xin Fu, Xueying Zhou, Peng Chen, Fanglei Han
The effective treatment of patients suffering from neuropathic pain remains challenging. Dexmedetomidine (DEX) possesses anti-inflammatory activity. However, the role of DEX in neuropathic pain is still unclear. The aim of the present study was to examine DEX an α2-adrenoceptor agonist could improve pain hypersensitivity and reduce inflammatory in a chronic constriction injury (CCI) model of the sciatic nerve in Sprague-Dawley rats. Dex was intrathecally administrated 1-h after operation. The paw mechanical withdrawal threshold (MWT) and paw withdrawal thermal latency (PWTL) were measured on day 1 before operation and on days 1, 7, 14 and 21 after operation, respectively...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28576901/anankle-trial-study-protocol-a-randomised-trial-comparing-pain-profiles-after-peripheral-nerve-block-or-spinal-anaesthesia-for-ankle-fracture-surgery
#19
Rune Sort, Stig Brorson, Ismail Gögenur, Ann Merete Møller
INTRODUCTION: Ankle fracture surgery is a common procedure, but the influence of anaesthesia choice on postoperative pain and quality of recovery is poorly understood. Some authors suggest a benefit of peripheral nerve block (PNB) in elective procedures, but the different pain profile following acute fracture surgery and the rebound pain on cessation of the PNB both remain unexplored. We present an ongoing randomised study aiming to compare primary PNB anaesthesia with spinal anaesthesia for ankle fracture surgery regarding postoperative pain profiles and quality of recovery...
June 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28542868/initial-placement-and-secondary-displacement-of-a-new-suture-method-catheter-for-sciatic-nerve-block-in-healthy-volunteers-a-randomised-double-blind-pilot-study
#20
T S Lyngeraa, C Rothe, C Steen-Hansen, M H Madsen, C B Christiansen, A M Andreasen, L H Lundstrøm, K H W Lange
We performed a randomised double-blind pilot study in 16 healthy volunteers to investigate the success rate for placing a new suture-method catheter for sciatic nerve block. A catheter was inserted into both legs of volunteers and each was randomly allocated to receive 15 ml lidocaine 2% through the catheter in one leg and 15 ml saline in the other leg. Successful placement of the catheter was defined as a 20% decrease in maximum voluntary isometric contraction for dorsiflexion of the ankle. Secondary outcomes were maximum voluntary isometric contraction for plantar flexion at the ankle, surface electromyography and cold sensation...
August 2017: Anaesthesia
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